CA1069182A - Muscle stimulator - Google Patents
Muscle stimulatorInfo
- Publication number
- CA1069182A CA1069182A CA249,670A CA249670A CA1069182A CA 1069182 A CA1069182 A CA 1069182A CA 249670 A CA249670 A CA 249670A CA 1069182 A CA1069182 A CA 1069182A
- Authority
- CA
- Canada
- Prior art keywords
- muscle
- pulse
- width
- pulses
- train
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3604—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation for correcting spinal deformities, e.g. scoliosis
Abstract
Abstract of the Disclosure An improved muscle stimulator, particularly suited to long term rhythmic stimulation for the selective development of musculature otherwise asymmetric or retard-ed in relative development. To minimize the subjects awareness of stimulation, to permit nocturnal use, and to minimize battery consumption, the energy content of each pulse train is modulated by a progressive increase of pulse width up to a maximum, followed by a progressive decrease of pulse width, thus yielding a gradual contrac-tion and relaxation of the muscle.
Description
10~;91~Z
~ackground of the Invention The response of muscle to an electrical current is believed to have been first observed and recorded by Galvani in 1791. All muscle is comprised of excitable cells which may be stimulated to contract by an applied electrical or chemical stimulus. The present invention is concerned only with skeletal and visceral muscle (sometimes referred to as striated and smooth muscle respectively) and not cardiac muscle in which the cells have a natural capacity for rhythmic contraction and a mutual coupling mechanism between cells. By contrast, skeletal and visceral muscle cells depolarize and contract only when acted upon by specific stimuli. Moreover, in skeletal and visceral muscle a depolarization does not naturally spread from a first depolarized cell to surrounding cells as in the case of cardiac muscle and this characteristic poses particular problems in artificially stimulating skeletal and visceral muscle. Cell depolarization in response to a natural stimulus is initiated at a multitude of sites within the muscle called synaptic clefts into which a - chemical transmitter is released by specialized nerve -bundles, the synaptic knobs.
Artificial electrical stimulation of muscle contraction by electrodes placed upon or into the muscle is thus a complex response of both muscle cells and nerve cells to the artificial stimulus. In order that either muscle cells or nerve cells may be depolarized, a given amount of work ~the product of electrical current times time) must be done. At minimum current levels only those cells immediately interfacing the electrode will be i~
. ~- . ., . , . -depolarized and as the current is increased those cells further away will also be depolarized. Where nerve cells are incorporated within the area of muscle subjected to current flow, above a threshold value, then muscle cells beyond the perimeter of the above threshold current flow can be depolarized by nerve propogation.
Thus, in general, it can be suggested that the magnitude of muscle contraction (that is the percentage of the cell total that is depolarized) is a function of stimulus intensity. In practice, in order to distribute the artificial contraction in an even manner the stimulus must be distributed by placing a multiplicity of electrodes on or ;nto the muscle.
Further, it is known that the ability of a cell to respond to a stimulus of given current magnitude is related to the duration of time during which the current flows. This is often expressed graphically as a "Strength-Duration Curve". Within limits, a reduction in time may be compensated by an increase in current. The forgoing data is well known to those experienced in the art. In man, artificial electrical stimulation of visceral and skeletal muscle has been employed therapeutically with limited success since the early 1960's.
In attempted control of the neurogenic bladder, stimulation of the detrusor, external sphincter and the bladder wall has been tried. The electrical parameters employed varied greatly as may be anticipated. Pulse voltages of 2 to 45 volts, pulse durations of O.S to 5 mSec, and pulse repetition frequencies of 10 to 25 Hz are recorded. In this application a burst or train of , ~ . .-. . . .: - .
.
.l ~ ` ~069~8Z
pulses within the range of parameters nominated is manually started and stopped. In an article entitled "Radio Frequency Electrophrenic Stimulation" by John P. Judson, M.D. and William L. Glenn, M.D., Journal American Medical Association, 203.12 (1968), pp. 1033-1037, there is reported artificial stimulation of respiration by stimulating the phrenic nerve with pulses of 0.1 mSec ; duration at 60 Hz repetition frequency and in trains of 1.7 Secs duration. Another article, entitled "Electrical Stimulation of Excitable Tissue by Radio-Frequency Transmission" by William W. L. Glenn, M.D., et al, Annals of Surgery, Sept. 1964, pp. 338-350 relates generally to the subject of electrical stimulation and at paga 339 describes what is probably the first therapeutically applied modulated pulse train intended to give a smooth control of inspiration and exhalation. This is gained by amplitude modulating the pulses of the wave train; the pulse width, repetition frequency and train duration remaining constant.
Summary of the Invention This invention relates to electrical stimulation of muscle and particularly to electrical stimulation applied to muscle, long term, to produce a rhythmic contraction and relaxation of the muscle. Such stimulation constitutes artificial exercise of the muscle and may be selectively , 25 applied to one muscle (or a related muscle group) such as f to develop or strengthen that muscle only, unlike natural exercise with which only limited selectivity is possible.
More specifically, the invention is incorporated ; in a muscle stimulator wherein a pulse width modulated train of electrical pulses is applied to muscle. The width of . .
-: .
the pulse may be modulated by a progressive or exponential increase in pulse width, followed by a progressive or exponential decrease in pulse width.
According to the broadest aspect of the invention there is provided a muscle stimulator for stimulating muscles having excitable cells comprising circuit means for generating a train of constant amplitude electrical pulses, terminal means connected to said circuit means adapted to electrically couple the circuit means to electrodes located at the muscle to be stimulated, said circuit means including modulation means for progressively and continuously increasing the width of the electrical pulses in said train from a minimum magnitude at which only those cells at the interface with the electrode are depolarized to a maximum magnitude at which cells remote from the electrode interface are depolarized and then progressively and continuously decreasing the pulse width to the minimum magnitude.
Brief Description of the Drawing FIGURE la is a wave diagram showing a pulse train which produces relatively unsatisfactory muscle response;
FIGURE lb is a diagram showing muscle response from the pulse train shown in FIGURE la;
FIGURE 2a is a diagram showing an ideal form of muscle response;
FIGURE 2b is a wave diagram showing a pulse train suitable to produce the muscle response shown in FIGURE 2a;
FIGURE 3a is a wave diagram showing a pulse train in accordance with the present invention;
FIGURE 3b is a diagram showing muscle response from 3Q the pulse train shown in FIGURE 3a;
~ ~ _5_ ~:
0~i9~2 FIGURE 4 is a schematic circuit diagram of a muscle stimulator in accordance with the invention;
FIGURE 5a is a diagram showing the output of NAND
gate 29 of FIGURE 4; and FIGURE 5b is a diagram showing the bias applied to transistor 35 of FIGURE 4.
Descrip*ion of the Preferred Embodiment The work which specifically led to the concept claimed herein, involved rhythmic stimulation of muscle contraction.
In childhood, approaching adolescence, a proportion of the populace evidences a slight curvature -5a-.
.
1069~82 of the lower spine. In the presence of certain other diagnostic indicators, it can be prognosed that this scoliotic curvature will progress to a severe deformity and chronic disability. Although the etiopathogenesis of the disease is not clearly understood, and may be significantly different in different subjects, it appears that satisfactory control and, potentially, reversal of the deformity may be gained by artificially exercising and hence strengthening a muscle group on the concave side of the spinal curvature.
The parameters of voltage, current, pulse width, pulse repetition frequency and pulse train duration employed to ~.his purpose are within the order of such parameters in the work of others. Empirically, a pulse voltage of 3.4 volts, a pulse duration maximum of 1.5 mSec., a pulse repetition fre~uency of 50 Hz, a pulse train duration of approximately 1-1/2 seconds and a pulse train repetition interval of approximately ten seconds have been chosen.
The stimulator has been designed as a completely implantable device (in the manner of a heart pacer) to ease the physicians' problems of patient management. This iæ particularly important with children and moreover, allows - the stimulator to be operated at night without the restraint on nocturnal rolling which would be necessary with a device applied externally to the patient. To be satis-factorily implantable for children the stimulator must be small, thus imposing a considerable constraint upon the amount of battery energy that may be incorporated.
Additionally, the stimulator once implanted should perform its function for at least two years before it becomes , ,~ ~069~BZ
necessary to reoperate because of exhausted batteries.
The simplest manner in which the muscle could be stimulated is by rhythmic pulse trains as illustrated in PIGURE la and this form of pulse train has the advantage that it S may be generated economically with a minimum of battery energy waste. It minimizes battery waste because it can be produced by on/off switching functions alone, and energy i8 only wasted during the short transitions from on to off. However, this form of pulse train evokes a muscle response as shown by FIGURE lb; a sharp contraction which i8 held and then terminated by a sharp relaxation. This type of muscle response would be of considerable discomfort to the patient and would innibit satisfactory sleep patterns.
An ideal form of muscle response is that shown by FIGURE
2a, a gradual increase in the magnitude of the contraction, up to a maximum, followed by a gradual relaxation phase.
Thi~ manner of muscle response can be produced by a stimulat-ing wave train as illustrated by FIGURE 2b, in which the ~ ~mplitude of the pulses is modulated. However, this form ;1 20 of control of pulse energy involves a major waste of battery energy; approximately the same amount of energy is dissipated in the pulse generator as is transmitted to the muscle.
~he present invention is directed to attaining the more ideal manner of muscle response without the waste ~1~ 25 of battery energy. It is accomplished by varying the width -`1 of the pulses in each pulse train. Theoretically, considering the ~trength-duration equation for cellular stimulation previously referred to, for any given pulse voltage and current, a finite minimum pulse width exists at which depolari zation of cells at the electrode interface will occur.
:
~ .
- . ...
As the pulse width is increased cells farther distant are depolarized and thus the magnitude of the muscle contraction may be controlled. A stimulator producing pulse trains, as shown by FIGURE 3a, was tested and shown to pxoduce a muscle response similar to FIGURE 3b~
As this manner of wavetrain can be generated using on/off switching elements, the electrical efficiency ; is high, greater than 90%. The generation and application of this manner of wave train for controlled muscle contraction is the essence of the present invention.
Although the invention is described with reference to one specific embodiment and for one particular thera-peu~ic application it should be recognized that wide variation in the form of the stimulator, including those dictated by alternative therapeutic applications, may be made while continuing to employ the essence of the invention and be within its spirit and scope.
The operation of the illustrative embodiment of the invention is described with reference to FIGURE
Terminals 11, 12, 13 and provided for connection to electrodes ~not shown) coupling the stimulating pulses to the muscle. In this embodiment there are employed two cathodically pulsed electrodes, for connection to terminals 11 and 12 and one anodic electrode for connection to terminal 13. However, a greater or lesser number of electrodes may be used depending upon the specific clinical application.
A battery 14, includes therein mercury cells in series to give a supply potential of 4.08 volts. A
capacitor 15 bypasses the battery supply to ensure a ~_ .
.
low impedance sourco. NAND gates 16 and 17 with associated resistors 18 and 19 and capacitors 20 and 21 form a free running pulse generatQr~ or logic clock, operating at a frequency of 100 Hz, Assuming that the output of gate 17 has switched from logic level 0 to logic level 1, the inputs to gate 16, wired as an inverter, will be switched, by way of capacitor 21, to logic level 1. The output of gate 16 and the inputs to gate 17, also wired as an inverter, will be at logic level 0, thus sustaining the logic level 1 status at the output of gate 17. The charge on capacitor 21 will leak away through resistor 18 until the potential at the inputs to gate 16 falls from logic level 1 to the logic level 0 input region cf gate 16. The output of gate 16 thus immediately switches to logic level 1, switching the output of gate 17 to logic level 0, reversing the charge on capacitor 21 and a new half cycle commences.
Thus the frequency of oscillation is essentially determined by the time constant of resistor 18 and capacitor 21 and in the embodiment described herein is approximately 5mSecs per half Cycle of the clock. The function of the resistor 19, connected from the negative battery supply to gates 16 and 17 and bypassed by capacitor 20, is to minimize the current drawn by the clock during that part of each half cycle when the voltage at the inputs of gate 16 is passing through the linear operating region of that gate.
The output of the clock is connected to a binary counter or divider 22. The binary counter 22 is a twelve bit counter, but in the present embodiment only ten bits are utilized. The output from gate 17 of the clock is _g_ ~()69~8Z
coupled to a clocking input 23 of counter 22. A reset terminal 24 is held permanently at logic level 0 so that the binary counter advances one bit at each transition of the clock from logic level 1 to logic level 0. Binary outputs 25 and 26 (counts of 256 and 512 respectivelyl are coupled to the inputs of NAND gate 27.
Output 25 changes state from logic level 1 to logic level 0 every 2.56 seconds (count of 256) and output 26 changes state from logic level 1 to logic level 0 every 5.12 seconds (count 512). Coincidence of logic levels 1 at the inputs of NAND gate 27 produces a logic level 0 output. The output of gate 27, normally at logic level 1, thus goes to logic level 0 for 1.28 seconds each 5.12 seconds. NAND gate 28 inverts the output of gate 27, and this inverted output is applied to the lower input of NAND
gate 29.
The upper input of NAND gate 29 is derived from binary output 30 (count of 1024) of counter 22. This output undergoes a logic level 1 to 0 change of state each 10.24 seconds.
The output 31 (count of 21 of binary counter 22, undergoes one complete cycle each 20 mSecs. This is coupled by way of capacitor 32 to inverter wired inputs of NAND gate 33. The inputs of gate 33 are biased to logic level 1 by resistor 34, which with capacitor 32 forms a critical time constant. The leading edge of each logic level O half cycle at terminal 31 drives the inputs of gate 33 to logic level 0, and commences a logic level 1 pulse at the output of gate 33. The time constant of capaci-tor 32 and resistor 34 (ignoring transistor 35) determines '-: ~ ' ~ - - . . :
1 ~ 9 ~8 ~
the time period during which the 10 mSec logic level 0 pulse at terminal 31 holds the output of gate 33 at logic level 1. The transistor 35, is in parallel with the time constant resistor 34, for a negative polarity at the inputs to gate 33. As previously stated, the output of NAND gate 29 is normally at logic level 1. Thus, by way of resistors 36 and 37 the transistor 35 is normally forward biased.
With transistor 35 forward biased the output pulse width of gate 33 is very short, typically less than 1% of the time constant of capacitor 32 and resistor 34.
As earlier stated, and as shown in FIGURE 5a, the output of NAND gate 29 goes from logic level 1 to 0 for 1.28 seconds each 10.24 seconds. As shown in FIG~r~
Sb, the time constant of resistor 36 and capacitor 38 is set such that during the 1.28 second logic level 0 pulse from gate 29, the initially forward bias at the base of transistor 35 decreases exponentially until the transistor 35 presents negligible current flow in shunt with resistor 34 at the end of the 1.28 second period. The bias on the transistor 35 is then exponentially re-established.
Thus, each 10.24 seconds, the normally very short (approximately S~Sec) pulses appearing at the output of gate 33 at 20mSec intervals will commence to increase in pulse width in an approximately exponential manner until a maximum width of approximately 1.5 mSec is reached, the successive pulse widths then decrease in an approximately exponential manner until the original condition is re-establish-ed. This sequence is illustrated (not to scale) by FIGU~E
3a. FIGURE 3b illustrates the consequent exponentially rising and falling energy distribution of the sequence.
106gl8Z
A small improvement in the operation of this circuit may be made by incorporating a resistance in series with the capacitor 32 such that the current sinking provided by transistor 3S, in its maximum forward biased condition, will reduce the pulse voltage at the inputs of gate 33 to a level lower than the logic transition level. Thus, during the period when transistor 35 is in its maximum forward biased condition there will be no output pulses at the output of gate 33, rather than the continual sequence of very short pulses. The logic level 1 pulses at the output of gate 33 are coupled by way of resistors 39 and 40 to the two common emitter output stages, transistors 41 z~d 42, so that each logic level 1 pulse at gate 33 forward biases both transistors 41 and 42. Each time transis-tors 41 and 42 are forward biased, some charge is transferred ;
from the capacitors 43 and 44 to the terminals 11 and 12 and by way of the electrodes (not shown) to the common terminal 13. During the period between output pulses, the charge upon capacitors 43 and 44 is restored by the resistors 45 and 46.
Alternative to employing separate output stages for each electrode, and with some consequent asymmetry of cathodic pulse current, a single output transistor may be employed with a single output coupling capacitor, and all the cathodic electrodes operated electrically in parallel.
In such an arrangement a lower value for the collector resistance and a higher value of output coupling capacit-ance must be employed.
The aforementioned circuit has been successfully constructed using the specific components listed below in Table I.
.
TABLE I
Battery 14 3 RMlcc mercury cells Counter - 5 22 Twelve bit binary counter MC14040cp. C.Mos.
Manufactured by Motorola Semiconductox Products, Inc.
Gates 16,17,27, Each is one-fourth of a Mc14011AL quad ~ 10 29,33 NAND gate. C.Mos. Manufactured by Motorola Semiconductor Products,'Inc.
Transistors 35,41,42 BC109 Capacitors ' 15 14,43,44 .33~fd .~ 20,21.,32 2200 ~f 38 0.47~fd Resistors 18,36 . 2.2 M ohm 19 220 K ohm .34 1 M ohm 37 120 K ohm : 39,40 22 K ohm 45,46 1.8 R oh~
' .
. .
.
~ackground of the Invention The response of muscle to an electrical current is believed to have been first observed and recorded by Galvani in 1791. All muscle is comprised of excitable cells which may be stimulated to contract by an applied electrical or chemical stimulus. The present invention is concerned only with skeletal and visceral muscle (sometimes referred to as striated and smooth muscle respectively) and not cardiac muscle in which the cells have a natural capacity for rhythmic contraction and a mutual coupling mechanism between cells. By contrast, skeletal and visceral muscle cells depolarize and contract only when acted upon by specific stimuli. Moreover, in skeletal and visceral muscle a depolarization does not naturally spread from a first depolarized cell to surrounding cells as in the case of cardiac muscle and this characteristic poses particular problems in artificially stimulating skeletal and visceral muscle. Cell depolarization in response to a natural stimulus is initiated at a multitude of sites within the muscle called synaptic clefts into which a - chemical transmitter is released by specialized nerve -bundles, the synaptic knobs.
Artificial electrical stimulation of muscle contraction by electrodes placed upon or into the muscle is thus a complex response of both muscle cells and nerve cells to the artificial stimulus. In order that either muscle cells or nerve cells may be depolarized, a given amount of work ~the product of electrical current times time) must be done. At minimum current levels only those cells immediately interfacing the electrode will be i~
. ~- . ., . , . -depolarized and as the current is increased those cells further away will also be depolarized. Where nerve cells are incorporated within the area of muscle subjected to current flow, above a threshold value, then muscle cells beyond the perimeter of the above threshold current flow can be depolarized by nerve propogation.
Thus, in general, it can be suggested that the magnitude of muscle contraction (that is the percentage of the cell total that is depolarized) is a function of stimulus intensity. In practice, in order to distribute the artificial contraction in an even manner the stimulus must be distributed by placing a multiplicity of electrodes on or ;nto the muscle.
Further, it is known that the ability of a cell to respond to a stimulus of given current magnitude is related to the duration of time during which the current flows. This is often expressed graphically as a "Strength-Duration Curve". Within limits, a reduction in time may be compensated by an increase in current. The forgoing data is well known to those experienced in the art. In man, artificial electrical stimulation of visceral and skeletal muscle has been employed therapeutically with limited success since the early 1960's.
In attempted control of the neurogenic bladder, stimulation of the detrusor, external sphincter and the bladder wall has been tried. The electrical parameters employed varied greatly as may be anticipated. Pulse voltages of 2 to 45 volts, pulse durations of O.S to 5 mSec, and pulse repetition frequencies of 10 to 25 Hz are recorded. In this application a burst or train of , ~ . .-. . . .: - .
.
.l ~ ` ~069~8Z
pulses within the range of parameters nominated is manually started and stopped. In an article entitled "Radio Frequency Electrophrenic Stimulation" by John P. Judson, M.D. and William L. Glenn, M.D., Journal American Medical Association, 203.12 (1968), pp. 1033-1037, there is reported artificial stimulation of respiration by stimulating the phrenic nerve with pulses of 0.1 mSec ; duration at 60 Hz repetition frequency and in trains of 1.7 Secs duration. Another article, entitled "Electrical Stimulation of Excitable Tissue by Radio-Frequency Transmission" by William W. L. Glenn, M.D., et al, Annals of Surgery, Sept. 1964, pp. 338-350 relates generally to the subject of electrical stimulation and at paga 339 describes what is probably the first therapeutically applied modulated pulse train intended to give a smooth control of inspiration and exhalation. This is gained by amplitude modulating the pulses of the wave train; the pulse width, repetition frequency and train duration remaining constant.
Summary of the Invention This invention relates to electrical stimulation of muscle and particularly to electrical stimulation applied to muscle, long term, to produce a rhythmic contraction and relaxation of the muscle. Such stimulation constitutes artificial exercise of the muscle and may be selectively , 25 applied to one muscle (or a related muscle group) such as f to develop or strengthen that muscle only, unlike natural exercise with which only limited selectivity is possible.
More specifically, the invention is incorporated ; in a muscle stimulator wherein a pulse width modulated train of electrical pulses is applied to muscle. The width of . .
-: .
the pulse may be modulated by a progressive or exponential increase in pulse width, followed by a progressive or exponential decrease in pulse width.
According to the broadest aspect of the invention there is provided a muscle stimulator for stimulating muscles having excitable cells comprising circuit means for generating a train of constant amplitude electrical pulses, terminal means connected to said circuit means adapted to electrically couple the circuit means to electrodes located at the muscle to be stimulated, said circuit means including modulation means for progressively and continuously increasing the width of the electrical pulses in said train from a minimum magnitude at which only those cells at the interface with the electrode are depolarized to a maximum magnitude at which cells remote from the electrode interface are depolarized and then progressively and continuously decreasing the pulse width to the minimum magnitude.
Brief Description of the Drawing FIGURE la is a wave diagram showing a pulse train which produces relatively unsatisfactory muscle response;
FIGURE lb is a diagram showing muscle response from the pulse train shown in FIGURE la;
FIGURE 2a is a diagram showing an ideal form of muscle response;
FIGURE 2b is a wave diagram showing a pulse train suitable to produce the muscle response shown in FIGURE 2a;
FIGURE 3a is a wave diagram showing a pulse train in accordance with the present invention;
FIGURE 3b is a diagram showing muscle response from 3Q the pulse train shown in FIGURE 3a;
~ ~ _5_ ~:
0~i9~2 FIGURE 4 is a schematic circuit diagram of a muscle stimulator in accordance with the invention;
FIGURE 5a is a diagram showing the output of NAND
gate 29 of FIGURE 4; and FIGURE 5b is a diagram showing the bias applied to transistor 35 of FIGURE 4.
Descrip*ion of the Preferred Embodiment The work which specifically led to the concept claimed herein, involved rhythmic stimulation of muscle contraction.
In childhood, approaching adolescence, a proportion of the populace evidences a slight curvature -5a-.
.
1069~82 of the lower spine. In the presence of certain other diagnostic indicators, it can be prognosed that this scoliotic curvature will progress to a severe deformity and chronic disability. Although the etiopathogenesis of the disease is not clearly understood, and may be significantly different in different subjects, it appears that satisfactory control and, potentially, reversal of the deformity may be gained by artificially exercising and hence strengthening a muscle group on the concave side of the spinal curvature.
The parameters of voltage, current, pulse width, pulse repetition frequency and pulse train duration employed to ~.his purpose are within the order of such parameters in the work of others. Empirically, a pulse voltage of 3.4 volts, a pulse duration maximum of 1.5 mSec., a pulse repetition fre~uency of 50 Hz, a pulse train duration of approximately 1-1/2 seconds and a pulse train repetition interval of approximately ten seconds have been chosen.
The stimulator has been designed as a completely implantable device (in the manner of a heart pacer) to ease the physicians' problems of patient management. This iæ particularly important with children and moreover, allows - the stimulator to be operated at night without the restraint on nocturnal rolling which would be necessary with a device applied externally to the patient. To be satis-factorily implantable for children the stimulator must be small, thus imposing a considerable constraint upon the amount of battery energy that may be incorporated.
Additionally, the stimulator once implanted should perform its function for at least two years before it becomes , ,~ ~069~BZ
necessary to reoperate because of exhausted batteries.
The simplest manner in which the muscle could be stimulated is by rhythmic pulse trains as illustrated in PIGURE la and this form of pulse train has the advantage that it S may be generated economically with a minimum of battery energy waste. It minimizes battery waste because it can be produced by on/off switching functions alone, and energy i8 only wasted during the short transitions from on to off. However, this form of pulse train evokes a muscle response as shown by FIGURE lb; a sharp contraction which i8 held and then terminated by a sharp relaxation. This type of muscle response would be of considerable discomfort to the patient and would innibit satisfactory sleep patterns.
An ideal form of muscle response is that shown by FIGURE
2a, a gradual increase in the magnitude of the contraction, up to a maximum, followed by a gradual relaxation phase.
Thi~ manner of muscle response can be produced by a stimulat-ing wave train as illustrated by FIGURE 2b, in which the ~ ~mplitude of the pulses is modulated. However, this form ;1 20 of control of pulse energy involves a major waste of battery energy; approximately the same amount of energy is dissipated in the pulse generator as is transmitted to the muscle.
~he present invention is directed to attaining the more ideal manner of muscle response without the waste ~1~ 25 of battery energy. It is accomplished by varying the width -`1 of the pulses in each pulse train. Theoretically, considering the ~trength-duration equation for cellular stimulation previously referred to, for any given pulse voltage and current, a finite minimum pulse width exists at which depolari zation of cells at the electrode interface will occur.
:
~ .
- . ...
As the pulse width is increased cells farther distant are depolarized and thus the magnitude of the muscle contraction may be controlled. A stimulator producing pulse trains, as shown by FIGURE 3a, was tested and shown to pxoduce a muscle response similar to FIGURE 3b~
As this manner of wavetrain can be generated using on/off switching elements, the electrical efficiency ; is high, greater than 90%. The generation and application of this manner of wave train for controlled muscle contraction is the essence of the present invention.
Although the invention is described with reference to one specific embodiment and for one particular thera-peu~ic application it should be recognized that wide variation in the form of the stimulator, including those dictated by alternative therapeutic applications, may be made while continuing to employ the essence of the invention and be within its spirit and scope.
The operation of the illustrative embodiment of the invention is described with reference to FIGURE
Terminals 11, 12, 13 and provided for connection to electrodes ~not shown) coupling the stimulating pulses to the muscle. In this embodiment there are employed two cathodically pulsed electrodes, for connection to terminals 11 and 12 and one anodic electrode for connection to terminal 13. However, a greater or lesser number of electrodes may be used depending upon the specific clinical application.
A battery 14, includes therein mercury cells in series to give a supply potential of 4.08 volts. A
capacitor 15 bypasses the battery supply to ensure a ~_ .
.
low impedance sourco. NAND gates 16 and 17 with associated resistors 18 and 19 and capacitors 20 and 21 form a free running pulse generatQr~ or logic clock, operating at a frequency of 100 Hz, Assuming that the output of gate 17 has switched from logic level 0 to logic level 1, the inputs to gate 16, wired as an inverter, will be switched, by way of capacitor 21, to logic level 1. The output of gate 16 and the inputs to gate 17, also wired as an inverter, will be at logic level 0, thus sustaining the logic level 1 status at the output of gate 17. The charge on capacitor 21 will leak away through resistor 18 until the potential at the inputs to gate 16 falls from logic level 1 to the logic level 0 input region cf gate 16. The output of gate 16 thus immediately switches to logic level 1, switching the output of gate 17 to logic level 0, reversing the charge on capacitor 21 and a new half cycle commences.
Thus the frequency of oscillation is essentially determined by the time constant of resistor 18 and capacitor 21 and in the embodiment described herein is approximately 5mSecs per half Cycle of the clock. The function of the resistor 19, connected from the negative battery supply to gates 16 and 17 and bypassed by capacitor 20, is to minimize the current drawn by the clock during that part of each half cycle when the voltage at the inputs of gate 16 is passing through the linear operating region of that gate.
The output of the clock is connected to a binary counter or divider 22. The binary counter 22 is a twelve bit counter, but in the present embodiment only ten bits are utilized. The output from gate 17 of the clock is _g_ ~()69~8Z
coupled to a clocking input 23 of counter 22. A reset terminal 24 is held permanently at logic level 0 so that the binary counter advances one bit at each transition of the clock from logic level 1 to logic level 0. Binary outputs 25 and 26 (counts of 256 and 512 respectivelyl are coupled to the inputs of NAND gate 27.
Output 25 changes state from logic level 1 to logic level 0 every 2.56 seconds (count of 256) and output 26 changes state from logic level 1 to logic level 0 every 5.12 seconds (count 512). Coincidence of logic levels 1 at the inputs of NAND gate 27 produces a logic level 0 output. The output of gate 27, normally at logic level 1, thus goes to logic level 0 for 1.28 seconds each 5.12 seconds. NAND gate 28 inverts the output of gate 27, and this inverted output is applied to the lower input of NAND
gate 29.
The upper input of NAND gate 29 is derived from binary output 30 (count of 1024) of counter 22. This output undergoes a logic level 1 to 0 change of state each 10.24 seconds.
The output 31 (count of 21 of binary counter 22, undergoes one complete cycle each 20 mSecs. This is coupled by way of capacitor 32 to inverter wired inputs of NAND gate 33. The inputs of gate 33 are biased to logic level 1 by resistor 34, which with capacitor 32 forms a critical time constant. The leading edge of each logic level O half cycle at terminal 31 drives the inputs of gate 33 to logic level 0, and commences a logic level 1 pulse at the output of gate 33. The time constant of capaci-tor 32 and resistor 34 (ignoring transistor 35) determines '-: ~ ' ~ - - . . :
1 ~ 9 ~8 ~
the time period during which the 10 mSec logic level 0 pulse at terminal 31 holds the output of gate 33 at logic level 1. The transistor 35, is in parallel with the time constant resistor 34, for a negative polarity at the inputs to gate 33. As previously stated, the output of NAND gate 29 is normally at logic level 1. Thus, by way of resistors 36 and 37 the transistor 35 is normally forward biased.
With transistor 35 forward biased the output pulse width of gate 33 is very short, typically less than 1% of the time constant of capacitor 32 and resistor 34.
As earlier stated, and as shown in FIGURE 5a, the output of NAND gate 29 goes from logic level 1 to 0 for 1.28 seconds each 10.24 seconds. As shown in FIG~r~
Sb, the time constant of resistor 36 and capacitor 38 is set such that during the 1.28 second logic level 0 pulse from gate 29, the initially forward bias at the base of transistor 35 decreases exponentially until the transistor 35 presents negligible current flow in shunt with resistor 34 at the end of the 1.28 second period. The bias on the transistor 35 is then exponentially re-established.
Thus, each 10.24 seconds, the normally very short (approximately S~Sec) pulses appearing at the output of gate 33 at 20mSec intervals will commence to increase in pulse width in an approximately exponential manner until a maximum width of approximately 1.5 mSec is reached, the successive pulse widths then decrease in an approximately exponential manner until the original condition is re-establish-ed. This sequence is illustrated (not to scale) by FIGU~E
3a. FIGURE 3b illustrates the consequent exponentially rising and falling energy distribution of the sequence.
106gl8Z
A small improvement in the operation of this circuit may be made by incorporating a resistance in series with the capacitor 32 such that the current sinking provided by transistor 3S, in its maximum forward biased condition, will reduce the pulse voltage at the inputs of gate 33 to a level lower than the logic transition level. Thus, during the period when transistor 35 is in its maximum forward biased condition there will be no output pulses at the output of gate 33, rather than the continual sequence of very short pulses. The logic level 1 pulses at the output of gate 33 are coupled by way of resistors 39 and 40 to the two common emitter output stages, transistors 41 z~d 42, so that each logic level 1 pulse at gate 33 forward biases both transistors 41 and 42. Each time transis-tors 41 and 42 are forward biased, some charge is transferred ;
from the capacitors 43 and 44 to the terminals 11 and 12 and by way of the electrodes (not shown) to the common terminal 13. During the period between output pulses, the charge upon capacitors 43 and 44 is restored by the resistors 45 and 46.
Alternative to employing separate output stages for each electrode, and with some consequent asymmetry of cathodic pulse current, a single output transistor may be employed with a single output coupling capacitor, and all the cathodic electrodes operated electrically in parallel.
In such an arrangement a lower value for the collector resistance and a higher value of output coupling capacit-ance must be employed.
The aforementioned circuit has been successfully constructed using the specific components listed below in Table I.
.
TABLE I
Battery 14 3 RMlcc mercury cells Counter - 5 22 Twelve bit binary counter MC14040cp. C.Mos.
Manufactured by Motorola Semiconductox Products, Inc.
Gates 16,17,27, Each is one-fourth of a Mc14011AL quad ~ 10 29,33 NAND gate. C.Mos. Manufactured by Motorola Semiconductor Products,'Inc.
Transistors 35,41,42 BC109 Capacitors ' 15 14,43,44 .33~fd .~ 20,21.,32 2200 ~f 38 0.47~fd Resistors 18,36 . 2.2 M ohm 19 220 K ohm .34 1 M ohm 37 120 K ohm : 39,40 22 K ohm 45,46 1.8 R oh~
' .
. .
.
Claims (5)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A muscle stimulator for stimulating muscles having excitable cells comprising circuit means for generating a train of constant amplitude electrical pulses, terminal means connected to said circuit means adapted to electrically couple the circuit means to electrodes located at the muscle to be stimulated, said circuit means including modulation means for progressively and continuously increasing the width of the electrical pulses in said train from a minimum magnitude at which only those cells at the interface with the electrode are depolarized to a maximum magnitude at which cells remote from the electrode interface are depolarized and then progressively and continuously decreasing the pulse width to the minimum magnitude.
2. A muscle stimulator as defined in claim 1 wherein said means for modulating the width of the electrical pulses comprises means for exponentially increasing the width of said pulse to a maximum and for exponentially decreasing the width of said pulses from said maximum to a minimum.
3. A muscle stimulator as defined in claim 1 wherein said circuit means includes means for applying said electrical pulses to said terminal means at a constant pulse repetition frequency.
4. A muscle stimulator as defined in claim 1 wherein said circuit means includes means for developing a pulse train having a pulse repetition frequency of approximately fifty pulses per second, a pulse train duration of about one and one-half seconds and a pulse train repetition interval of about ten seconds.
5. A muscle stimulator as defined in claim 4 wherein said means for modulating the width of said electrical pulses includes means for limiting the width of said pulses to about 1/2 milliseconds.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US05/579,506 US3983881A (en) | 1975-05-21 | 1975-05-21 | Muscle stimulator |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1069182A true CA1069182A (en) | 1980-01-01 |
Family
ID=24317167
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA249,670A Expired CA1069182A (en) | 1975-05-21 | 1976-04-06 | Muscle stimulator |
Country Status (4)
Country | Link |
---|---|
US (1) | US3983881A (en) |
AU (1) | AU498941B2 (en) |
CA (1) | CA1069182A (en) |
GB (1) | GB1543178A (en) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4121594A (en) * | 1977-09-26 | 1978-10-24 | Med General, Inc. | Transcutaneous electrical nerve stimulator |
US4167190A (en) * | 1977-10-21 | 1979-09-11 | Medtronic, Inc. | Pulse dosage control unit for tissue stimulation system |
US4153059A (en) * | 1977-10-25 | 1979-05-08 | Minnesota Mining And Manufacturing Company | Urinary incontinence stimulator system |
JPS54119792A (en) * | 1978-03-03 | 1979-09-17 | Iriyou Kougaku Kenkiyuushiyo K | Electric stimulation device for removing pain |
US4256116A (en) * | 1978-07-03 | 1981-03-17 | Technion Research And Development Foundation, Limited | Transcutaneous pain reliever |
US4233986A (en) * | 1978-07-18 | 1980-11-18 | Agar Ginosar Electronics And Metal Products | Apparatus and method for controlling pain by transcutaneous electrical stimulation (TES) |
US4431000A (en) * | 1978-11-29 | 1984-02-14 | Gatron Corporation | Transcutaneous nerve stimulator with pseusorandom pulse generator |
US4326534A (en) * | 1979-06-21 | 1982-04-27 | Jens Axelgaard | Transcutaneous electrical muscle stimulation for treatment of scoliosis and other spinal deformities |
US4243043A (en) * | 1979-07-11 | 1981-01-06 | Sevastianov Viktor V | Apparatus for electrical stimulation of mammae |
YU272580A (en) * | 1980-10-23 | 1982-10-31 | Inst Jozef Stefan | Control circuit of a therapeutic stimulator for urine incontinency |
US4537195A (en) * | 1980-11-20 | 1985-08-27 | Mcdonnell Roy E | Electrical control of body discharges and headaches |
USRE32091E (en) * | 1981-03-13 | 1986-03-11 | Medtronic, Inc. | Neuromuscular stimulator |
US4392496A (en) * | 1981-03-13 | 1983-07-12 | Medtronic, Inc. | Neuromuscular stimulator |
NL8105297A (en) * | 1981-11-23 | 1983-06-16 | Ver Wetens Onderwijs Gereform | METHOD FOR GENERATING NERVE OR MUSCLE STIMULATION SIGNALS |
US4411268A (en) * | 1982-02-10 | 1983-10-25 | Medtronic, Inc. | Muscle stimulator |
US4688575A (en) * | 1982-03-12 | 1987-08-25 | Duvall Wilbur E | Muscle contraction stimulation |
US4520825A (en) * | 1982-04-30 | 1985-06-04 | Medtronic, Inc. | Digital circuit for control of gradual turn-on of electrical tissue stimulators |
US4492233A (en) * | 1982-09-14 | 1985-01-08 | Wright State University | Method and apparatus for providing feedback-controlled muscle stimulation |
CA1215128A (en) * | 1982-12-08 | 1986-12-09 | Pedro Molina-Negro | Electric nerve stimulator device |
US4595010A (en) * | 1984-03-12 | 1986-06-17 | Bio-Research Associates, Inc. | Electrical muscle stimulator |
GB8406509D0 (en) * | 1984-03-13 | 1984-04-18 | Bio Medical Res Ltd | Electrical stimulation of muscle |
US4646744A (en) * | 1984-06-29 | 1987-03-03 | Zion Foundation | Method and treatment with transcranially applied electrical signals |
DE3570982D1 (en) * | 1985-04-01 | 1989-07-20 | Oscobal Ag | Electrostimulation apparatus, particularly for scoliosis treatment |
AT385664B (en) * | 1985-07-31 | 1988-05-10 | Hepax Ltd | ELECTROMEDICAL THERAPY DEVICE |
US4769881A (en) * | 1986-09-02 | 1988-09-13 | Pedigo Irby R | High precision tens apparatus and method of use |
JPS6456060A (en) * | 1987-08-27 | 1989-03-02 | Hayashibara Takeshi | Low frequency medical treatment device |
BR8800201A (en) * | 1988-01-21 | 1989-09-05 | Antonio Ilson Giordani | ELECTROSTIMULATOR |
US5038781A (en) * | 1988-01-21 | 1991-08-13 | Hassan Hamedi | Multi-electrode neurological stimulation apparatus |
US4934368A (en) * | 1988-01-21 | 1990-06-19 | Myo/Kinetics Systems, Inc. | Multi-electrode neurological stimulation apparatus |
US5447526A (en) * | 1992-12-24 | 1995-09-05 | Karsdon; Jeffrey | Transcutaneous electric muscle/nerve controller/feedback unit |
AU6118799A (en) | 1998-10-06 | 2000-04-26 | Bio Control Medical, Ltd. | Incontinence treatment device |
IL127481A (en) * | 1998-10-06 | 2004-05-12 | Bio Control Medical Ltd | Incontinence treatment device |
US6516226B1 (en) | 1999-12-01 | 2003-02-04 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system for minimizing electrode insertion discomfort |
US6539264B1 (en) | 1999-12-01 | 2003-03-25 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with sharp point protection |
US6912424B2 (en) * | 1999-12-01 | 2005-06-28 | Meagan, Medical, Inc. | Apparatus and method for coupling therapeutic and/or monitoring equipment to a patient |
US6549810B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode depth control |
US6542780B1 (en) | 1999-12-01 | 2003-04-01 | Vertis Neuroscience, Inc. | Method and apparatus for electrically coupling a percutaneous probe |
US6560491B1 (en) | 1999-12-01 | 2003-05-06 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system providing electrode axial support |
US6493592B1 (en) | 1999-12-01 | 2002-12-10 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode position maintenance |
US6622051B1 (en) | 1999-12-01 | 2003-09-16 | Vertis Neuroscience, Inc. | Percutaneous electrical therapy system with electrode entry angle control |
US6522927B1 (en) | 1999-12-01 | 2003-02-18 | Vertis Neuroscience, Inc. | Electrode assembly for a percutaneous electrical therapy system |
US6904324B2 (en) * | 1999-12-01 | 2005-06-07 | Meagan Medical, Inc. | Method and apparatus for deploying a percutaneous probe |
US6556869B1 (en) | 1999-12-01 | 2003-04-29 | Vertis Neuroscience, Inc. | Electrode introducer for a percutaneous electrical therapy system |
US6549797B1 (en) | 1999-12-01 | 2003-04-15 | Vertis Neuroscience, Inc. | Electrode remover for a percutaneous electrical therapy system |
US7118555B2 (en) * | 2000-09-21 | 2006-10-10 | Meagan Medical, Inc. | Method and apparatus for repositioning a percutaneous probe |
US6671557B1 (en) | 2000-10-10 | 2003-12-30 | Meagan Medical, Inc. | System and method for providing percutaneous electrical therapy |
US20030082884A1 (en) * | 2001-10-26 | 2003-05-01 | International Business Machine Corporation And Kabushiki Kaisha Toshiba | Method of forming low-leakage dielectric layer |
IL162193A0 (en) * | 2001-11-29 | 2005-11-20 | Biocontrol Medical Ltd | Pelvic disorder treatment device |
US6712772B2 (en) | 2001-11-29 | 2004-03-30 | Biocontrol Medical Ltd. | Low power consumption implantable pressure sensor |
US6862480B2 (en) | 2001-11-29 | 2005-03-01 | Biocontrol Medical Ltd. | Pelvic disorder treatment device |
US7050856B2 (en) | 2002-01-11 | 2006-05-23 | Medtronic, Inc. | Variation of neural-stimulation parameters |
US7228184B2 (en) * | 2003-02-22 | 2007-06-05 | Chester Heath | Viral-inhibiting method |
ATE507871T1 (en) * | 2003-11-07 | 2011-05-15 | Cardiola Ltd | ELECTROTHERAPEUTIC DEVICE FOR TREATING A PERSON OR A MAMMAL |
US8195296B2 (en) | 2006-03-03 | 2012-06-05 | Ams Research Corporation | Apparatus for treating stress and urge incontinence |
WO2007114875A1 (en) * | 2006-04-04 | 2007-10-11 | Ams Research Corporation | Apparatus for implanting neural stimulation leads |
EP2004282A4 (en) * | 2006-04-07 | 2009-05-27 | Global Energy Medicine Pty Ltd | In vivo stimulation of cellular material |
US8355789B2 (en) * | 2006-04-28 | 2013-01-15 | Medtronic, Inc. | Method and apparatus providing asynchronous neural stimulation |
US20070265675A1 (en) * | 2006-05-09 | 2007-11-15 | Ams Research Corporation | Testing Efficacy of Therapeutic Mechanical or Electrical Nerve or Muscle Stimulation |
KR101379640B1 (en) * | 2006-06-05 | 2014-04-11 | 에이엠에스 리서치 코포레이션 | Electrical muscle stimulation to treat fecal incontinence and/or pelvic prolapse |
US8160710B2 (en) * | 2006-07-10 | 2012-04-17 | Ams Research Corporation | Systems and methods for implanting tissue stimulation electrodes in the pelvic region |
US20090012592A1 (en) * | 2006-07-10 | 2009-01-08 | Ams Research Corporation | Tissue anchor |
US7881803B2 (en) | 2006-10-18 | 2011-02-01 | Boston Scientific Neuromodulation Corporation | Multi-electrode implantable stimulator device with a single current path decoupling capacitor |
CA2666420C (en) * | 2006-10-18 | 2014-01-28 | Boston Scientific Neuromodulation Corporation | Multi-electrode implantable stimulator device with a single current path decoupling capacitor |
US8571662B2 (en) | 2007-01-29 | 2013-10-29 | Simon Fraser University | Transvascular nerve stimulation apparatus and methods |
US7844340B2 (en) * | 2007-01-31 | 2010-11-30 | Pawlowicz Iii John S | Devices and methods for transcutaneous electrical neural stimulation |
US9427573B2 (en) | 2007-07-10 | 2016-08-30 | Astora Women's Health, Llc | Deployable electrode lead anchor |
US20100049289A1 (en) | 2007-07-10 | 2010-02-25 | Ams Research Corporation | Tissue anchor |
US9539433B1 (en) | 2009-03-18 | 2017-01-10 | Astora Women's Health, Llc | Electrode implantation in a pelvic floor muscular structure |
US8380312B2 (en) * | 2009-12-31 | 2013-02-19 | Ams Research Corporation | Multi-zone stimulation implant system and method |
US9220887B2 (en) | 2011-06-09 | 2015-12-29 | Astora Women's Health LLC | Electrode lead including a deployable tissue anchor |
EP2753397B1 (en) | 2011-09-08 | 2017-01-11 | AMS Research Corporation | Implantable electrode assembly |
EP3556427B1 (en) | 2012-03-05 | 2022-06-08 | Lungpacer Medical Inc. | Transvascular nerve stimulation apparatus |
CN104684614B (en) | 2012-06-21 | 2017-10-17 | 西蒙·弗雷泽大学 | The diaphragm pacing system and application method of intravascular |
WO2015075548A1 (en) | 2013-11-22 | 2015-05-28 | Simon Fraser University | Apparatus and methods for assisted breathing by transvascular nerve stimulation |
AU2015208640B2 (en) | 2014-01-21 | 2020-02-20 | Lungpacer Medical Inc. | Systems and related methods for optimization of multi-electrode nerve pacing |
US9364667B1 (en) | 2014-03-31 | 2016-06-14 | Elassia LLC | Potentiating or eliciting an erotic sensation in a body using electrostimulation |
US10293164B2 (en) | 2017-05-26 | 2019-05-21 | Lungpacer Medical Inc. | Apparatus and methods for assisted breathing by transvascular nerve stimulation |
EP4115942B1 (en) | 2017-06-30 | 2024-04-24 | Lungpacer Medical Inc. | System for prevention, moderation, and/or treatment of cognitive injury |
US10195429B1 (en) | 2017-08-02 | 2019-02-05 | Lungpacer Medical Inc. | Systems and methods for intravascular catheter positioning and/or nerve stimulation |
US10940308B2 (en) | 2017-08-04 | 2021-03-09 | Lungpacer Medical Inc. | Systems and methods for trans-esophageal sympathetic ganglion recruitment |
EP3877043A4 (en) | 2018-11-08 | 2022-08-24 | Lungpacer Medical Inc. | Stimulation systems and related user interfaces |
JP2022532375A (en) | 2019-05-16 | 2022-07-14 | ラングペーサー メディカル インコーポレイテッド | Systems and methods for detection and stimulation |
JP2022536478A (en) | 2019-06-12 | 2022-08-17 | ラングペーサー メディカル インコーポレイテッド | Circuits for medical stimulation systems |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2099511A (en) * | 1933-03-16 | 1937-11-16 | Caesar Viktor | Oscillator for the biological treatment of living tissue |
US2700975A (en) * | 1950-12-08 | 1955-02-01 | Hopfinger Otto | High-frequency apparatus for painless epilation |
DE974944C (en) * | 1951-09-13 | 1961-06-08 | Siemens Reiniger Werke Ag | Medical electrical stimulation apparatus, especially for phrenic nerve stimulation |
DE2158132C2 (en) * | 1971-11-24 | 1974-01-03 | Robert Bosch Elektronik Gmbh, 1000 Berlin Und 7000 Stuttgart | Stimulation current diagnostic device |
US3773051A (en) * | 1972-03-01 | 1973-11-20 | Research Corp | Method and apparatus for stimulation of body tissue |
-
1975
- 1975-05-21 US US05/579,506 patent/US3983881A/en not_active Expired - Lifetime
-
1976
- 1976-04-06 CA CA249,670A patent/CA1069182A/en not_active Expired
- 1976-04-08 GB GB14352/76A patent/GB1543178A/en not_active Expired
- 1976-05-21 AU AU14196/76A patent/AU498941B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB1543178A (en) | 1979-03-28 |
AU1419676A (en) | 1977-11-24 |
US3983881A (en) | 1976-10-05 |
AU498941B2 (en) | 1979-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1069182A (en) | Muscle stimulator | |
RU2306155C2 (en) | Method and device for bioelectric stimulation, high-speed wound healing and pain relief | |
US4222386A (en) | Method for stimulating cardiac action by means of implanted _electrocardiostimulator and implantable electrocardiostimulator for effecting same | |
US5257623A (en) | Apparatus for generating electric pulses for biological object stimulation | |
US4612934A (en) | Non-invasive multiprogrammable tissue stimulator | |
US4456012A (en) | Iontophoretic and electrical tissue stimulation device | |
US4326534A (en) | Transcutaneous electrical muscle stimulation for treatment of scoliosis and other spinal deformities | |
US4793353A (en) | Non-invasive multiprogrammable tissue stimulator and method | |
KR0154112B1 (en) | Method and apparatus for pulsed iontophoretic drug delivery | |
US5447526A (en) | Transcutaneous electric muscle/nerve controller/feedback unit | |
US3667477A (en) | Implantable vesical stimulator | |
DE60308652T2 (en) | Stimulating device for a living body | |
US6011994A (en) | Multipurpose biomedical pulsed signal generator | |
US3344792A (en) | Method of muscular stimulation in human beings to aid in walking | |
SK286262B6 (en) | Augmentation of muscle contractility by biphasic stimulation | |
CZ299883B6 (en) | Apparatus for electrical stimulation of heart | |
NZ169605A (en) | Electromedical device: modifies electric potentials in non-human living bodies | |
JPH05502608A (en) | Method and device for epilepsy treatment | |
CN105288849B (en) | A kind of implantable neural electrical stimulator with modulating mode | |
US3881494A (en) | Electro pulse arthritic physiotherapy system | |
Baratta et al. | Method for studying muscle properties under orderly stimulated motor units with tripolar nerve cuff electrode | |
US6856837B2 (en) | Method and device for electrochemically building of muscle | |
RU80752U1 (en) | ELECTRIC STIMULATOR FOR PHYSIOTHERAPY OF THE INTERNAL HUMAN BODIES IN THE AREA OF THE SMALL PELVIS | |
Mahdavi et al. | Designing Ultra-low-power Cardiac Pacemaker with Quantum Cellular Automation Technology | |
Eftekhar et al. | Towards a reconfigurable sense-and-stimulate neural interface generating biphasic interleaved stimulus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKEX | Expiry |