CA1098084A - Cap closure and method of producing same - Google Patents
Cap closure and method of producing sameInfo
- Publication number
- CA1098084A CA1098084A CA321,340A CA321340A CA1098084A CA 1098084 A CA1098084 A CA 1098084A CA 321340 A CA321340 A CA 321340A CA 1098084 A CA1098084 A CA 1098084A
- Authority
- CA
- Canada
- Prior art keywords
- port
- base portion
- membrane
- cap
- protector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1406—Septums, pierceable membranes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1412—Containers with closing means, e.g. caps
- A61J1/1431—Permanent type, e.g. welded or glued
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D47/00—Closures with filling and discharging, or with discharging, devices
- B65D47/04—Closures with discharging devices other than pumps
- B65D47/32—Closures with discharging devices other than pumps with means for venting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1468—Containers characterised by specific material properties
Abstract
ABSTRACT OF THE DISCLOSURE
A cap closure is provided for bonding to the neck of a container. The cap closure includes a base portion enclosed by a side wall, a peripheral rim exten-ing outwardly from the side wall with the rim being adapted for bonding to the neck of the container, an administration port connected to the base portion, a medication addition port connected to the base portion, a resealable injection site connected to the medication addition port, and port protectors covering and hermetically sealing the administration and medication addition ports. In the illustrative embodiment, the base portion, side wall, peripheral rim, administration port and medication addition ports are molded as an integral, unitary member, and a method is provided for fusing a membrane to the medication addition port and for fusing port protectors with the base member.
A cap closure is provided for bonding to the neck of a container. The cap closure includes a base portion enclosed by a side wall, a peripheral rim exten-ing outwardly from the side wall with the rim being adapted for bonding to the neck of the container, an administration port connected to the base portion, a medication addition port connected to the base portion, a resealable injection site connected to the medication addition port, and port protectors covering and hermetically sealing the administration and medication addition ports. In the illustrative embodiment, the base portion, side wall, peripheral rim, administration port and medication addition ports are molded as an integral, unitary member, and a method is provided for fusing a membrane to the medication addition port and for fusing port protectors with the base member.
Description
BACKGROUND OF THE INVENTION
The present invention concerns a noval cap closure for bonding to the neck of a container, and a method for producing a cap closure, Sterile pharmaceutical solutions, such as 5~ dextrose, normal saline and the like, are supplied to hospitals for infusion into a patient's veins from a container hanging above the patient. The sterile liquid flows by gravity through a tubular administration set connected at one end to the container and at an opposite end to a venous needle in the patient, Such containers are requently formed of thermo-plastic material, and will include a neck portion having an opening extending through the neck portion. As used in the specification and claims herein, the term "neck portion"
includes the generally vertically oriented neck of the ~on-tainer and any generally horizontally oriented platform or base extending from the neck or depending from the neck~
The a~oresaid container will generally include a closure or stopper which carries or defines one or more ports, with the po~ts being hermetically sealed to provide sterile sealed contents to the container. An example o~ such a container is disclosed in McPhee U.SO Patent No.3,900,n28.
It is desixable that the port be in a sterile environ~ent.
In copending Canadian application Serial No. 297,889 filed February 28, 1978 in the name of David A. Winchell, entitled "Hermetically Sealed Tamperproof Port Protector", and assigned to the assignee of the present invention, a thermo~
plastic port protector is disclosed which covers the port and defines a frangible section. The closure has a length to diameter ratio providing good mechanical advantage leverage to rupture the frangible section when the closure is pushed sideways.
" .
.~ , sd/ ~
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It is an object of the present invention to pro~ide a cap closure for bonding to the neck of a container, which cap closure receives port protector means with a hermetic seal.
Another object of the present invention is to pro-vide a cap closure for bonding to the neck of a contairler, which cap closure carries an administration port and a medication addltion port, and is simple and efficient to manufacture.
A further obiect of the present invention is to provide a cap closure for pharmaceutical containers, such as an IV container or a blood container, which can be bonded to the neck of the container and can be easily sterilized.
Another object of the present invention is to provide a cap closure for bonding to the nec]c of a pharma~eutical container, which cap closure carries an administration port and a medication addition port, and which cap closllre allows port protectors to be bonded thereto with a.hermetic sealO
A Eurther object of the present invention is to pro-vide an e~icient method for produciny a cap closure for bonding to the neck of a pharmaceutical containerO
Other objects and advanta~es of the present invention will become apparent as the description proceeds.
SUMMARY OF THE INVF~TION
-One illustrative emhodiment of the present invention i5 illustrated in FIGURES 6~10 of Canadian patent application Serial No. 297,889, filed February 28, 1978 and . ~ , ,, I ~
assigned to the assignee of the present invention. In accordance with the present invention, a cap closure for bonding to the neck of a container is pro~ided. The cap closure includes a base portion enclosed by a side wall, and a peripheral rim extending outwardly from and connected to the side wall, with the rim being adapted for bonding to the neck of the container. An administra-tion port and a medication addition port are connected to the base portion, and a resealable injection site is connected to the medication addition port. Port protector means cover and hermetically seal the administration and medication addition ports.
In the illustrative embodiment, rib means are carried by the cap and extend from the bottom of the base portion. The rib means operate to prevent the cap from deforming during sterilization.
In the illustrative embodiment, the base portion, side wall, peripheral rim, administration port, medication addition port and rib means are all molded as an integral, unitar~ member.
In the illustrative embodiment, the port protector means comprise a protector cap that is hermetically bonded to the base portion. The base portion includes a raised island portion surrounding the administration and medication addition ports, to r~ceive the protector cap and to provide a relief area for molten material to flow when the protector cap is being bonded to the base portion.
In the method of producing a cap closure for a container in accordance with the present invention, a unitar~ mcmber is molded, which unitary member includes a b~se portion, an administration port on the base portion, and a medication addition port on the base portion.
Membrane material is positioned over the medication addition port and a membrane is punched out of the membrane material by a heated die haviny a lar~er area dimension than the medication addition port area dimension. The punched-out membrane is pressed to the top of the medication addition port by the heated die, so that the membrane and port portion adjacent thereto become molten and are fused together.
In the illustrative embodiment, a raised island portion is provided surrounding the ports. A port protector is positioned on the raised island portion over each of the ports and a heated die is brought into thermal contact with the port protector and the island to fuse the port protector with the island, and thereby hermetically seal the ports.
A more detailed explanation of the invention is provided in the followiny description and claims, and is illustrated in the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGURE l is an exploded perspective view of a cap closure constructed in accordance with the principles of the present invention;
FIGURE 2 is an enlarged cross-sectional elevation of a cap closuxe constructed in accordance with the principles of the present invention; and FIGURE 3 is a bottom view of the closure cap of FIGURE 2.
DETAILED DESCRIPTION OF THE
ILLUSTRATIVE EMBODIMENT
.
Referring to the drawings, there is fragmenkarily illustrated a thermoplastic container 10 haviny an inteyral neck portion 12. The neck portion 12 is formed integrally with the body of the container 10 in a conventional manner. The top 14 of the neck portion 12 comprises a sealing surface for a cap closure and includes a hori-zontal outer portion 16 and a raised inner ring 18. The sealing of the cap closure to top surface 14 of neck 12 will be described in more detail below.
Cap closure 20 comprises a unitary inteclral molded member, preferably formed of polyolefin material.
The cap closure 20 includes a base portion 22 enclosed by a circular side wall 24, with an annular peripheral rim 26 extending outwardly from the top of the side wall 24. Base portion 22 carries an administration port 28 and a medication addition port 30. A raised island, ; preferably 0.015 inch higher than the plane of the remainder of base portion 22, surrounds ports 28 and 30 and has a generally figure~eight shape. The raised island 32 around the ports provides a relief area for molten material to flow under the port protector heat sealing die as described below.
In order to prevent the closure cap 20 from deforming during sterilization, as well as preventing deformation during the heat welding stages of the cap closure assembly, a number of ribs 34 are provided across the bottom of the cap. The preferred confiyuration of ribs 34 is i~lustrated in FIGURE 3.
Medication addition port 30 defines a bore 38 which is sealed by means of a membrane 40. Membrane 40 is preferably formed from an extruded strip of polyolefin material having a thickness of 0.005 inch. The strip of membrane material is positioned over the top of the medication addition port 30 and is punched-out of the strip by a heated die having a slightly larger diameter than the diameter of the port 30. The heated die presses the rnembrane material to the top oE port 30 so that the membrane and the top of port 30 become molten and are fused together. As shown most clearly in FIGURE 2, a circumferential lip 42 is formed at the top of port 30 which aids in retaining injection site 44.
The injection site 44 is formed of a rubber material and is pressure-fit snugly with respect to port 30 as shown most clearl~ in FIGURE 2. The polyolefin membrane 40, in combination with injection site 44, does not "core" when punctured.
As shown in FIGURE 2, a membrane 46 is molded with the cap closure 20 and is located to lie in the plane of base portion 22. By recessing membrane 46 away from the walls of port 28, touch contamination is prevented when hospital personne]L attach an administra-tion set to administration port 28. Membrane 4h remains attached to the closure when it is punctured.
The internal walls of the administration port 28 have a slight internal taper to provide a tight fit with the external wall of the administration set spike before it penetrates the membraneO This aids in preventing leakage of the solution.
The top of peripheral rim 26 lies in a parallel plane with respect to base portion 22, and also bisects the height of the ports 28 and 30 which are substantially e~ual in height. Thus, the side wall 24 and peripheral flange 26 surround a portion of the ports to aid in preventin~ touch contamination during use.
]~'ort,q 28 and 30 are }lermetically sealed by rneans ~ oE port protectorC. 50 and 52, respectively. q'~e~e port ....
protectors are described in copending ~ patent application 5erial No. 297,889~ and assigned to the assignee of the present inventionO These port protectors sa ~ 52 comprise a pair of molded thermo plastic caps which carry an external flange 54 to form a unitary structure. Port protectors 50 and 52 have a leng~h to diameter ratio to provide a good mechanical advantage leverage, so that they can be easily popped off.
After the membrane 40 and injection site 44 are assemblea to port 30, port protectors 50 and 52 are placed over ports 28 and 30, respectively, so that flange 54 will overlie island 32. .A heated die is then brought down over the port protectors 50 and 52, making contact with flange 54~ The die heats the flange 54 until it becomes molten and at the same time heats the top surface of island 32 to a molten stage~ The two materials ar~
used together to form a frangible seal, which is a hermetic seal allowing either port protector to be removed without disturbing the integrit~ of the otherO
~he cap closure 20 is heat welded to the neck 12 of the container 10. To this end, the bottom surface of peripheral ~lange 26 is heated and the top surface 14 and ring 18 are heated until there is a ~ilm of molten plastic on the surfaces. The closure cap is then pressed to~ether with khe container neck, whereby the side wall 24 is inserted into the opening defined by ring 18 and the flange 26 is p.ressed onto ring 18 and top surface 14 to orm a hermetic seal 56 (FIGURE 2).
It can be seen that a cap as~embly has been provided which is simple in construction and easy to manufacture. When an administration set is to be con-nected to container 10, protcctor cap 50 is broken off and the .spiX~ from the adminis~rat.ion set is inserted into port 28 through membrane 46. To inject medicament, port protector 52 is broken oEf and a syringe needle is inserted through injection site 44 and membrane 40.
Although an illustrative embodiment of the invention has been shown and described, it is to be understood that various modificati.ons and substitutions may be made by those skilled in the art without departing from the novel spirit and scope of the present invention.
The present invention concerns a noval cap closure for bonding to the neck of a container, and a method for producing a cap closure, Sterile pharmaceutical solutions, such as 5~ dextrose, normal saline and the like, are supplied to hospitals for infusion into a patient's veins from a container hanging above the patient. The sterile liquid flows by gravity through a tubular administration set connected at one end to the container and at an opposite end to a venous needle in the patient, Such containers are requently formed of thermo-plastic material, and will include a neck portion having an opening extending through the neck portion. As used in the specification and claims herein, the term "neck portion"
includes the generally vertically oriented neck of the ~on-tainer and any generally horizontally oriented platform or base extending from the neck or depending from the neck~
The a~oresaid container will generally include a closure or stopper which carries or defines one or more ports, with the po~ts being hermetically sealed to provide sterile sealed contents to the container. An example o~ such a container is disclosed in McPhee U.SO Patent No.3,900,n28.
It is desixable that the port be in a sterile environ~ent.
In copending Canadian application Serial No. 297,889 filed February 28, 1978 in the name of David A. Winchell, entitled "Hermetically Sealed Tamperproof Port Protector", and assigned to the assignee of the present invention, a thermo~
plastic port protector is disclosed which covers the port and defines a frangible section. The closure has a length to diameter ratio providing good mechanical advantage leverage to rupture the frangible section when the closure is pushed sideways.
" .
.~ , sd/ ~
$~
It is an object of the present invention to pro~ide a cap closure for bonding to the neck of a container, which cap closure receives port protector means with a hermetic seal.
Another object of the present invention is to pro-vide a cap closure for bonding to the neck of a contairler, which cap closure carries an administration port and a medication addltion port, and is simple and efficient to manufacture.
A further obiect of the present invention is to provide a cap closure for pharmaceutical containers, such as an IV container or a blood container, which can be bonded to the neck of the container and can be easily sterilized.
Another object of the present invention is to provide a cap closure for bonding to the nec]c of a pharma~eutical container, which cap closure carries an administration port and a medication addition port, and which cap closllre allows port protectors to be bonded thereto with a.hermetic sealO
A Eurther object of the present invention is to pro-vide an e~icient method for produciny a cap closure for bonding to the neck of a pharmaceutical containerO
Other objects and advanta~es of the present invention will become apparent as the description proceeds.
SUMMARY OF THE INVF~TION
-One illustrative emhodiment of the present invention i5 illustrated in FIGURES 6~10 of Canadian patent application Serial No. 297,889, filed February 28, 1978 and . ~ , ,, I ~
assigned to the assignee of the present invention. In accordance with the present invention, a cap closure for bonding to the neck of a container is pro~ided. The cap closure includes a base portion enclosed by a side wall, and a peripheral rim extending outwardly from and connected to the side wall, with the rim being adapted for bonding to the neck of the container. An administra-tion port and a medication addition port are connected to the base portion, and a resealable injection site is connected to the medication addition port. Port protector means cover and hermetically seal the administration and medication addition ports.
In the illustrative embodiment, rib means are carried by the cap and extend from the bottom of the base portion. The rib means operate to prevent the cap from deforming during sterilization.
In the illustrative embodiment, the base portion, side wall, peripheral rim, administration port, medication addition port and rib means are all molded as an integral, unitar~ member.
In the illustrative embodiment, the port protector means comprise a protector cap that is hermetically bonded to the base portion. The base portion includes a raised island portion surrounding the administration and medication addition ports, to r~ceive the protector cap and to provide a relief area for molten material to flow when the protector cap is being bonded to the base portion.
In the method of producing a cap closure for a container in accordance with the present invention, a unitar~ mcmber is molded, which unitary member includes a b~se portion, an administration port on the base portion, and a medication addition port on the base portion.
Membrane material is positioned over the medication addition port and a membrane is punched out of the membrane material by a heated die haviny a lar~er area dimension than the medication addition port area dimension. The punched-out membrane is pressed to the top of the medication addition port by the heated die, so that the membrane and port portion adjacent thereto become molten and are fused together.
In the illustrative embodiment, a raised island portion is provided surrounding the ports. A port protector is positioned on the raised island portion over each of the ports and a heated die is brought into thermal contact with the port protector and the island to fuse the port protector with the island, and thereby hermetically seal the ports.
A more detailed explanation of the invention is provided in the followiny description and claims, and is illustrated in the accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
FIGURE l is an exploded perspective view of a cap closure constructed in accordance with the principles of the present invention;
FIGURE 2 is an enlarged cross-sectional elevation of a cap closuxe constructed in accordance with the principles of the present invention; and FIGURE 3 is a bottom view of the closure cap of FIGURE 2.
DETAILED DESCRIPTION OF THE
ILLUSTRATIVE EMBODIMENT
.
Referring to the drawings, there is fragmenkarily illustrated a thermoplastic container 10 haviny an inteyral neck portion 12. The neck portion 12 is formed integrally with the body of the container 10 in a conventional manner. The top 14 of the neck portion 12 comprises a sealing surface for a cap closure and includes a hori-zontal outer portion 16 and a raised inner ring 18. The sealing of the cap closure to top surface 14 of neck 12 will be described in more detail below.
Cap closure 20 comprises a unitary inteclral molded member, preferably formed of polyolefin material.
The cap closure 20 includes a base portion 22 enclosed by a circular side wall 24, with an annular peripheral rim 26 extending outwardly from the top of the side wall 24. Base portion 22 carries an administration port 28 and a medication addition port 30. A raised island, ; preferably 0.015 inch higher than the plane of the remainder of base portion 22, surrounds ports 28 and 30 and has a generally figure~eight shape. The raised island 32 around the ports provides a relief area for molten material to flow under the port protector heat sealing die as described below.
In order to prevent the closure cap 20 from deforming during sterilization, as well as preventing deformation during the heat welding stages of the cap closure assembly, a number of ribs 34 are provided across the bottom of the cap. The preferred confiyuration of ribs 34 is i~lustrated in FIGURE 3.
Medication addition port 30 defines a bore 38 which is sealed by means of a membrane 40. Membrane 40 is preferably formed from an extruded strip of polyolefin material having a thickness of 0.005 inch. The strip of membrane material is positioned over the top of the medication addition port 30 and is punched-out of the strip by a heated die having a slightly larger diameter than the diameter of the port 30. The heated die presses the rnembrane material to the top oE port 30 so that the membrane and the top of port 30 become molten and are fused together. As shown most clearly in FIGURE 2, a circumferential lip 42 is formed at the top of port 30 which aids in retaining injection site 44.
The injection site 44 is formed of a rubber material and is pressure-fit snugly with respect to port 30 as shown most clearl~ in FIGURE 2. The polyolefin membrane 40, in combination with injection site 44, does not "core" when punctured.
As shown in FIGURE 2, a membrane 46 is molded with the cap closure 20 and is located to lie in the plane of base portion 22. By recessing membrane 46 away from the walls of port 28, touch contamination is prevented when hospital personne]L attach an administra-tion set to administration port 28. Membrane 4h remains attached to the closure when it is punctured.
The internal walls of the administration port 28 have a slight internal taper to provide a tight fit with the external wall of the administration set spike before it penetrates the membraneO This aids in preventing leakage of the solution.
The top of peripheral rim 26 lies in a parallel plane with respect to base portion 22, and also bisects the height of the ports 28 and 30 which are substantially e~ual in height. Thus, the side wall 24 and peripheral flange 26 surround a portion of the ports to aid in preventin~ touch contamination during use.
]~'ort,q 28 and 30 are }lermetically sealed by rneans ~ oE port protectorC. 50 and 52, respectively. q'~e~e port ....
protectors are described in copending ~ patent application 5erial No. 297,889~ and assigned to the assignee of the present inventionO These port protectors sa ~ 52 comprise a pair of molded thermo plastic caps which carry an external flange 54 to form a unitary structure. Port protectors 50 and 52 have a leng~h to diameter ratio to provide a good mechanical advantage leverage, so that they can be easily popped off.
After the membrane 40 and injection site 44 are assemblea to port 30, port protectors 50 and 52 are placed over ports 28 and 30, respectively, so that flange 54 will overlie island 32. .A heated die is then brought down over the port protectors 50 and 52, making contact with flange 54~ The die heats the flange 54 until it becomes molten and at the same time heats the top surface of island 32 to a molten stage~ The two materials ar~
used together to form a frangible seal, which is a hermetic seal allowing either port protector to be removed without disturbing the integrit~ of the otherO
~he cap closure 20 is heat welded to the neck 12 of the container 10. To this end, the bottom surface of peripheral ~lange 26 is heated and the top surface 14 and ring 18 are heated until there is a ~ilm of molten plastic on the surfaces. The closure cap is then pressed to~ether with khe container neck, whereby the side wall 24 is inserted into the opening defined by ring 18 and the flange 26 is p.ressed onto ring 18 and top surface 14 to orm a hermetic seal 56 (FIGURE 2).
It can be seen that a cap as~embly has been provided which is simple in construction and easy to manufacture. When an administration set is to be con-nected to container 10, protcctor cap 50 is broken off and the .spiX~ from the adminis~rat.ion set is inserted into port 28 through membrane 46. To inject medicament, port protector 52 is broken oEf and a syringe needle is inserted through injection site 44 and membrane 40.
Although an illustrative embodiment of the invention has been shown and described, it is to be understood that various modificati.ons and substitutions may be made by those skilled in the art without departing from the novel spirit and scope of the present invention.
Claims (25)
1. A cap closure for bonding to the neck of a container, which comprises:
a base portion enclosed by a side wall;
a peripheral rim extending outwardly from and connected to said side wall, said rim being adapted for bonding to the neck of the container;
an administration port connected to said base portion;
a medication addition port connected to said base portion;
a resealable injection site connected to said medication addition port; and port protector means covering and hermetically sealing said administration and medication addition ports, said port protector means comprising a protector cap hermetically bonded to said base portion.
a base portion enclosed by a side wall;
a peripheral rim extending outwardly from and connected to said side wall, said rim being adapted for bonding to the neck of the container;
an administration port connected to said base portion;
a medication addition port connected to said base portion;
a resealable injection site connected to said medication addition port; and port protector means covering and hermetically sealing said administration and medication addition ports, said port protector means comprising a protector cap hermetically bonded to said base portion.
2. A cap closure as described in Claim 1, including rib means carried by said cap and extending from the bottom of said base portion, said rib means operating to prevent the cap from deforming during sterilization.
3. A cap closure as described in Claim 2, said base portion, side wall, peripheral rim, administration port, medication addition port and rib means all molded as an integral, unitary member.
4. A cap closure as described in Claim 3, wherein said peripheral rim is connected at the top of said side wall.
5. A cap closure as described in Claim 4, said base portion including a raised island portion surround-ing said administration and medication addition ports to receive said protector cap and to provide a relief area for molten material to flow when the protector cap is being bonded to said base portion.
6. A cap closure as described in Claim 1, said medication addition port defining an opening that is sealed by a membrane, with the injection site overlying said membrane, whereby the injection site will not be in direct communication with the contents of a container to which the cap closure is connected.
7. A cap closure as described in Claim 6, said membrane and said medication addition port seal providing a peripheral lip which aids in retaining the injection site.
8. A cap closure as described in Claim 1, said administration port including a membrane normally closing said port prior to use, said membrane being positioned below the top of the port to prevent touch contamination when an administration set is connected to the adminstration port.
9. A cap closure as described in Claim 8, said membrane lying substantially in the plane of the base portion.
10. A cap closure as described in Claim 1, said peripheral rim having a top surface that is in a higher plane than the base portion whexeby said peripheral rim serves as a wall enclosing a portion of said ports.
11. A cap closure as described in Claim 10, wherein the top of said peripheral rim lies in a plane which is substantially perpendicular to the axes of the ports, and is parallel to the plane of the base portion and lies substantially mid-point between said base portion and the top plane of the ports, with the ports having top surfaces that are substantially coplanar.
12. A cap closure as described in claim 1, and further including a container for receiving the cap closure, said container including a substantially hori-zontal cap sealing surface and an upwardly extending raised ring portion extending therefrom, said side wall of said cap being adapted for receipt within said ring with said peripheral rim overlying said ring portion and said sealing surface.
13. A cap closure as described in Claim 1, said peripheral rim connected at the top of said side wall.
14. A cap closure for bonding to the neck of a container, which comprises:
a base portion enclosed by a side wall;
a peripheral rim extending outwardly from and connected to said side wall, said rim being adapted for bonding to the neck of the container;
an administration port connected to said base portion;
a medication addition port connected to said base portion;
rib means carried by said cap closure and extending from the bottom of said base portion, said rib means operating to prevent the cap from deforming during sterilization;
said base portion, side wall, peripheral rim, administration port, medication addition port, and rib means all being molded as an integral unitary member;
a resealable injection site connected to said medication addition port;
port protector means covering and hermetically sealing said administration and medication addition ports, said port protector means comprising a protector cap hermetically bonded to said base portion; and said base portion including a raised island portion surrounding said administration and medication addition ports, to receive said protector cap and to provide a relief area for molten material to flow when the protector cap is being bonded to said base portion.
a base portion enclosed by a side wall;
a peripheral rim extending outwardly from and connected to said side wall, said rim being adapted for bonding to the neck of the container;
an administration port connected to said base portion;
a medication addition port connected to said base portion;
rib means carried by said cap closure and extending from the bottom of said base portion, said rib means operating to prevent the cap from deforming during sterilization;
said base portion, side wall, peripheral rim, administration port, medication addition port, and rib means all being molded as an integral unitary member;
a resealable injection site connected to said medication addition port;
port protector means covering and hermetically sealing said administration and medication addition ports, said port protector means comprising a protector cap hermetically bonded to said base portion; and said base portion including a raised island portion surrounding said administration and medication addition ports, to receive said protector cap and to provide a relief area for molten material to flow when the protector cap is being bonded to said base portion.
15. A cap closure as described in Claim 14, said medication addition port defining an opening that is sealed by a membrane, with the injection site overlying said membrane, said membrane being formed of a polyolefin material and said injection site being formed of a rubber material, said membrane and medication addition port seal providing a peripheral lip which aids in retaining the injection site.
16. A cap closure for bonding to the neck of a container, which comprises:
a base portion enclosed by a side wall;
a peripheral rim extending outwardly from and connected to said side wall, said rim being adapted for bonding to the neck of the container;
an administration port connected to said base portion, said administration port including a membrane normally closing said port prior to use, said membrane lying substantially in the plane of the base portion and thus being positioned below the top of the port, to prevent touch contamination when an administration set is connected to the administration port;
a medication addition port connected to said base portion, said medication addition port defining an opening that is sealed by a membrane;
a resealable injection site connected to said medication addition port and overlying said membrane; and port protector means covering and hermetically sealing said administration and medication addition ports, said port protector means comprising a protector cap hermetically bonded to said base portion.
a base portion enclosed by a side wall;
a peripheral rim extending outwardly from and connected to said side wall, said rim being adapted for bonding to the neck of the container;
an administration port connected to said base portion, said administration port including a membrane normally closing said port prior to use, said membrane lying substantially in the plane of the base portion and thus being positioned below the top of the port, to prevent touch contamination when an administration set is connected to the administration port;
a medication addition port connected to said base portion, said medication addition port defining an opening that is sealed by a membrane;
a resealable injection site connected to said medication addition port and overlying said membrane; and port protector means covering and hermetically sealing said administration and medication addition ports, said port protector means comprising a protector cap hermetically bonded to said base portion.
17. A cap closure as described in Claim 16, and further including a container having a neck for receiving the cap closure, said container neck including a substantially horizontal cap sealing surface and an upwardly extending raised ring portion extending therefrom, said side wall of said cap being adapted for receipt within said ring with said peripheral rim overlying said ring portion and said sealing surface,
18. A method of producing a cap closure for a container comprising the steps of:
molding a unitary member including a base portion and at least one port on the base portion, positioning membrane material over the port;
punching a membrane out of the membrane material with a heated die having a larger area dimension than the dimension of the port area; and pressing the punched-out membrane onto the top of the port, whereby the membrane and the port portion adjacent thereto become molten and are fused together and a peripheral lip is formed around the membrane.
molding a unitary member including a base portion and at least one port on the base portion, positioning membrane material over the port;
punching a membrane out of the membrane material with a heated die having a larger area dimension than the dimension of the port area; and pressing the punched-out membrane onto the top of the port, whereby the membrane and the port portion adjacent thereto become molten and are fused together and a peripheral lip is formed around the membrane.
19. A method is described in Claim 18 including the steps of:
providing a raised island portion surrounding the port; positioning a port protector over the part with an external flange of the port protector overlying the island;
and bringing a heated die into thermal contact with the flange and the island to fuse the port protector to the island and thereby hermetically seal the port.
providing a raised island portion surrounding the port; positioning a port protector over the part with an external flange of the port protector overlying the island;
and bringing a heated die into thermal contact with the flange and the island to fuse the port protector to the island and thereby hermetically seal the port.
20. A method of producing a cap closure for a container comprising the steps of:
molding a unitary member including a base portion and at least one port on the base portion;
providing a raised island portion surrounding the port;
positioning a port protector over the port with an external flange of the port protector overlying the island;
and bringing a heated die into thermal contact with the flange and the island to fuse the port protector to the island and thereby hermetically seal the port.
molding a unitary member including a base portion and at least one port on the base portion;
providing a raised island portion surrounding the port;
positioning a port protector over the port with an external flange of the port protector overlying the island;
and bringing a heated die into thermal contact with the flange and the island to fuse the port protector to the island and thereby hermetically seal the port.
21. A method as described in Claim 18 wherein the port included in the base portion is a medication addition port.
22. A method as described in Claim 19 wherein the port included in the base portion is a medication addition port.
23. A method as described in Claim 22 further comprising the step of providing an administration port in the base portion.
24. A method as described in Claim 20 wherein the port included in the base portion is an administration port.
25. A method of producing a cap closure for a container comprising the steps of:
molding a unitary member including a base portion and at least one port member on the base portion, said molding including forming plural ribs across said unitary member on a side opposite said port member;
positioning membrane material over said port member;
punching a membrane out of the membrane material with a heated die having a larger area dimension than the port member area;
pressing the punched out membrane on to the top of the port member, whereby the membrane and port member portion adjacent thereto become molten and are fused together and a peripheral lip is formed around the membrane, said rib pre-venting deformation of said unitary member during said pressing step;
providing a raised island portion surrounding the port member;
positioning a port member protector over the port member with an external flange of the port member protector overlying the island; and bringing a heated die into thermal contact with the flange and the island to fuse the port member protector to the island and thereby hermetically seal the port member.
molding a unitary member including a base portion and at least one port member on the base portion, said molding including forming plural ribs across said unitary member on a side opposite said port member;
positioning membrane material over said port member;
punching a membrane out of the membrane material with a heated die having a larger area dimension than the port member area;
pressing the punched out membrane on to the top of the port member, whereby the membrane and port member portion adjacent thereto become molten and are fused together and a peripheral lip is formed around the membrane, said rib pre-venting deformation of said unitary member during said pressing step;
providing a raised island portion surrounding the port member;
positioning a port member protector over the port member with an external flange of the port member protector overlying the island; and bringing a heated die into thermal contact with the flange and the island to fuse the port member protector to the island and thereby hermetically seal the port member.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US885,480 | 1978-03-13 | ||
| US05/885,480 US4153173A (en) | 1978-03-13 | 1978-03-13 | Cap closure and method of producing same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1098084A true CA1098084A (en) | 1981-03-24 |
Family
ID=25386991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA321,340A Expired CA1098084A (en) | 1978-03-13 | 1979-02-13 | Cap closure and method of producing same |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US4153173A (en) |
| JP (1) | JPS54129795A (en) |
| AU (1) | AU528203B2 (en) |
| BE (1) | BE874770A (en) |
| CA (1) | CA1098084A (en) |
| CH (1) | CH639042A5 (en) |
| DE (1) | DE2909859A1 (en) |
| ES (1) | ES478545A1 (en) |
| FR (1) | FR2419876A1 (en) |
| GB (1) | GB2016430B (en) |
| IE (1) | IE48193B1 (en) |
| IL (1) | IL56680A (en) |
| IT (1) | IT1111714B (en) |
| NO (1) | NO790811L (en) |
| SE (1) | SE7901596L (en) |
| ZA (1) | ZA79632B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8211081B2 (en) | 2004-10-20 | 2012-07-03 | Fresenius Kabi Deutschland Gmbh | Closing cap for containers filled with medical liquids |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE7832028U1 (en) * | 1978-10-27 | 1979-04-19 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | CLOSURE FOR A PLASTIC INFUSION BAG |
| US4279352A (en) * | 1979-03-12 | 1981-07-21 | Baxter Travenol Laboratories, Inc. | Molded injection site |
| US4508236A (en) * | 1982-09-13 | 1985-04-02 | Baxter Travenol Laboratories, Inc. | Container and associated cap assembly for plasma collection and the like |
| US4568345A (en) * | 1982-09-13 | 1986-02-04 | Baxter Travenol Laboratories, Inc. | Container and associated cap assembly for plasma collection and the like |
| US4523691A (en) * | 1983-04-08 | 1985-06-18 | Abbott Laboratories | Port structure for I.V. container |
| DE3815623A1 (en) * | 1988-05-07 | 1989-11-16 | Merck Patent Gmbh | DISCHARGE LOCK FOR LIQUID CONTAINERS |
| US4951845A (en) * | 1989-01-17 | 1990-08-28 | Abbott Laboratories | Closure with filter |
| US4934545A (en) * | 1989-01-19 | 1990-06-19 | Abbott Laboratories | Closure with microbial filter |
| JP2923302B2 (en) * | 1989-05-17 | 1999-07-26 | テルモ株式会社 | Tubular body with diaphragm |
| US5188628A (en) * | 1990-11-06 | 1993-02-23 | Sandoz Ltd. | Closure device for enteral fluid containers |
| US5267791A (en) * | 1991-12-13 | 1993-12-07 | Corning Incorporated | Suspended cell culture stirring vessel closure and apparatus |
| DE4405965C2 (en) * | 1994-02-24 | 1997-08-07 | Bernd Hansen | Infusion container with two connections |
| NL1004059C2 (en) * | 1996-09-18 | 1998-03-19 | Plastic Moulding Appliances B | Assembly of container and snap closure and method for the manufacture thereof. |
| US20070235105A1 (en) * | 2006-03-28 | 2007-10-11 | Ramsey Philip W | Bottle cap system that facilitates suction-driven filling of a bottle with a fluid |
| DE102007024539A1 (en) * | 2007-05-24 | 2008-11-27 | Fresenius Kabi Deutschland Gmbh | Cap for a container for holding liquids, in particular an enteral nutrient solution and container with such a cap |
| US8857639B2 (en) * | 2010-02-03 | 2014-10-14 | Paha Designs, Llc | Pressure equalization apparatus for a bottle and methods associated therewith |
| US9796506B2 (en) | 2010-02-03 | 2017-10-24 | Paha Designs, Llc | Pressure equalization apparatus for a bottle and methods associated therewith |
| EP2359799A1 (en) * | 2010-02-16 | 2011-08-24 | Fresenius Kabi Deutschland GmbH | Closure cap for a container for holding medicinal liquids and container |
| CN105283165A (en) * | 2013-03-24 | 2016-01-27 | 凯孚尔有限公司 | Installation for producing a bag for medical purposes, method for producing such a bag, injection stopper and bag for medical purposes |
| USD860675S1 (en) | 2016-12-29 | 2019-09-24 | Conopco, Inc. | Cartridge |
| USD862924S1 (en) | 2016-12-29 | 2019-10-15 | Conopco, Inc. | Dispenser |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2665816A (en) * | 1950-03-21 | 1954-01-12 | Anft Otto | Multiple compartmented bottle |
| US2665024A (en) * | 1951-01-15 | 1954-01-05 | Baxter Don Inc | Pharmaceutical closure |
| US3025988A (en) * | 1959-07-20 | 1962-03-20 | Owens Illinois Glass Co | Non-removable closure |
| FR1372589A (en) * | 1963-08-05 | 1964-09-18 | Desjonqueres Plastiques | Stoppering device for receptacles intended to receive either blood, blood derivatives, or aqueous injectable preparations, the active principles of which are either in solution or in suspension |
| GB1175428A (en) * | 1967-03-30 | 1969-12-23 | Hartmut Luhleich | Improvements in Self-Sealing Pierceable Membranes and Applications thereof |
| US3480172A (en) * | 1968-04-09 | 1969-11-25 | Baxter Laboratories Inc | Reclosed package |
| US3655102A (en) * | 1969-12-15 | 1972-04-11 | James G Moran | Bottle cap and cover |
| US3923179A (en) * | 1973-03-07 | 1975-12-02 | American Hospital Supply Corp | Medical liquid container with tactile sterility indicator and method of testing container |
| US4000829A (en) * | 1973-08-16 | 1977-01-04 | Johnson Enterprises, Inc. | Container closure unit |
| US3905368A (en) * | 1974-02-15 | 1975-09-16 | Cutter Lab | Pierceable access port assembly |
| US3921630A (en) * | 1974-02-26 | 1975-11-25 | American Hospital Supply Corp | Thermoplastic bottle with controlled lateral collapse and method of dispensing liquid therefrom |
| US3900028A (en) * | 1974-02-26 | 1975-08-19 | American Hospital Supply Corp | Injection site for sterile medical liquid container |
| FR2261931A1 (en) * | 1974-02-26 | 1975-09-19 | American Hospital Supply Corp | |
| SE388178B (en) * | 1974-09-06 | 1976-09-27 | Pharmacia Ab | SEATING CLOSE FOR CONTAINERS |
| IL54167A (en) * | 1977-03-14 | 1980-05-30 | Baxter Travenol Lab | Frangible protective sealing arrangement |
| US4174238A (en) * | 1977-03-14 | 1979-11-13 | Baxter Travenol Laboratories, Inc. | Hermetically sealed tamperproof port protector and method of making frangible seal |
-
1978
- 1978-03-13 US US05/885,480 patent/US4153173A/en not_active Expired - Lifetime
-
1979
- 1979-02-13 ZA ZA79632A patent/ZA79632B/en unknown
- 1979-02-13 CA CA321,340A patent/CA1098084A/en not_active Expired
- 1979-02-15 IL IL5668079A patent/IL56680A/en unknown
- 1979-02-22 SE SE7901596A patent/SE7901596L/en not_active Application Discontinuation
- 1979-03-05 FR FR7905592A patent/FR2419876A1/en active Granted
- 1979-03-07 CH CH220879A patent/CH639042A5/en not_active IP Right Cessation
- 1979-03-09 JP JP2816879A patent/JPS54129795A/en active Granted
- 1979-03-12 GB GB7908661A patent/GB2016430B/en not_active Expired
- 1979-03-12 NO NO790811A patent/NO790811L/en unknown
- 1979-03-12 ES ES478545A patent/ES478545A1/en not_active Expired
- 1979-03-12 IT IT2091779A patent/IT1111714B/en active
- 1979-03-12 BE BE0/193967A patent/BE874770A/en not_active IP Right Cessation
- 1979-03-13 AU AU45069/79A patent/AU528203B2/en not_active Ceased
- 1979-03-13 DE DE19792909859 patent/DE2909859A1/en active Granted
- 1979-08-09 IE IE724/79A patent/IE48193B1/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8211081B2 (en) | 2004-10-20 | 2012-07-03 | Fresenius Kabi Deutschland Gmbh | Closing cap for containers filled with medical liquids |
Also Published As
| Publication number | Publication date |
|---|---|
| ES478545A1 (en) | 1979-11-16 |
| IL56680A (en) | 1981-07-31 |
| FR2419876A1 (en) | 1979-10-12 |
| IE48193B1 (en) | 1984-10-31 |
| US4153173A (en) | 1979-05-08 |
| AU528203B2 (en) | 1983-04-21 |
| BE874770A (en) | 1979-07-02 |
| IL56680A0 (en) | 1979-05-31 |
| FR2419876B1 (en) | 1985-04-19 |
| JPS54129795A (en) | 1979-10-08 |
| IT7920917A0 (en) | 1979-03-12 |
| DE2909859A1 (en) | 1979-09-27 |
| DE2909859C2 (en) | 1991-11-07 |
| IT1111714B (en) | 1986-01-13 |
| SE7901596L (en) | 1979-09-14 |
| ZA79632B (en) | 1980-03-26 |
| CH639042A5 (en) | 1983-10-31 |
| GB2016430B (en) | 1982-11-03 |
| GB2016430A (en) | 1979-09-26 |
| NO790811L (en) | 1979-09-14 |
| IE790724L (en) | 1979-09-13 |
| JPH0113859B2 (en) | 1989-03-08 |
| AU4506979A (en) | 1979-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |