CA1148633A - Device for monitoring and controlling self- administered intravenous drug dosage - Google Patents
Device for monitoring and controlling self- administered intravenous drug dosageInfo
- Publication number
- CA1148633A CA1148633A CA000365323A CA365323A CA1148633A CA 1148633 A CA1148633 A CA 1148633A CA 000365323 A CA000365323 A CA 000365323A CA 365323 A CA365323 A CA 365323A CA 1148633 A CA1148633 A CA 1148633A
- Authority
- CA
- Canada
- Prior art keywords
- signal
- demand
- timer
- inject
- drug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
- A61M5/1452—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of pistons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/13—Infusion monitoring
Abstract
ABSTRACT OF THE DISCLOSURE
A device for monitoring and controlling the opera-tion of a motorized syringe to dispense a predetermined drug dosage comprises, according to one aspect of this invention, a combination of a trigger, a first signal monitor, a first timer, a second signal monitor and a second timer. The trigger is operable by the patient to initiate a demand signal indicative of a demand for an individual drug dose. The first signal monitor serves to record the total number of occasions on which a demand signal is initiated by operation of the trigger. The first timer receives the demand signal and selectively rejects the demand signal or emits the demand signal as an inject signal. The second signal monitor records the total number of occasions on which the first timer emits a demand signal. The second timer receives the inject signal and is operable upon receipt of the inject signal to acti-vate a motorized syringe for a preselected time period to dispense a predetermined individual dose of drug.
A device for monitoring and controlling the opera-tion of a motorized syringe to dispense a predetermined drug dosage comprises, according to one aspect of this invention, a combination of a trigger, a first signal monitor, a first timer, a second signal monitor and a second timer. The trigger is operable by the patient to initiate a demand signal indicative of a demand for an individual drug dose. The first signal monitor serves to record the total number of occasions on which a demand signal is initiated by operation of the trigger. The first timer receives the demand signal and selectively rejects the demand signal or emits the demand signal as an inject signal. The second signal monitor records the total number of occasions on which the first timer emits a demand signal. The second timer receives the inject signal and is operable upon receipt of the inject signal to acti-vate a motorized syringe for a preselected time period to dispense a predetermined individual dose of drug.
Description
This in~ntion relates to a device for monitoring and controlling self-administration of intravenous drug dosages.
PRIOR ART
Several instruments have been developed for the pur-poses of permitting a patient to control the rate of adminis-tration of drug dosages by an intravenous injection system.
Motorized syringes capable of injecting a predetermined drug dosage in response to the receipt of an electrical signal are known. Examples of such motorized syringes are those sold under the trade name CARDIF PALLITOR and manufactured by Pye Electronics Limited.
In previously known devices for monitoring and con-trolling the operation of a motorized syringe, a trigger is provided which the patient can operate to generate a demand signal and a timer is provided for recèiving the demand signal and selectively rejecting the demand signal or passing the demand signal as an inject signal to the motorized syringe and-a single counter is provided. In one such prior device the counter counts the total number of occasions on which the ~0 trigger is activated. In another device the single counter counts the total number of occasions on which the timer passes the demand signal as an inject signal.
Generally it has been the practice to monitor the total number of inject signals as this serves to give the phvsician an indication of ~e total amount of drug which has been administered to the patient.
, In order to control the level of pain which a patient experiences, :it is necessarv to maintain a certain drug level ~ in the patienl:'s blood. When drugs are administered bY a ; 30 physician or a nurse, it is necessary tQ maintain a dosing , -2- !~
~B~;:33 interval of the order of thr~e to four hours. As a result of this_practice, the initial blood level will be high and will decline progressively over the balance of the dosing i~terval. Thus, the patient initially receives an overdose of the drug which will decline and become an underdose toward the end of the dosing interval. It is well known that there are two techniques by which the high swing in blood level con-centration may be reduced. One! method is to employ drugs which have a long half-life and the other is to reduce the individual dosages and to shorten the dosing intervals. The use of analgesics which have a long half-life, such as mor phine, makes it essential that the correct individual dosage for a particular patient be accurately determined because the patient's metabolism will require several hours to correct any such errors. In the alternative, where the dosage inter val is to be shortened in order to reduce the blood level concentration swings, it is necessary to employ a machine ~-~ich permits self-administration of drug dosages.
The previously known machines used for the self-administration of drug dosages permit a reduction in the size - of the individual dose and a shortening of the dosing inter-vals. The effectiveness of the dosing strategy is, however, - determined by the physiciàn as a result of consultations with the patient. There are many circumstances under which a physician is unable to communicate with a patient in order to obtain an indica~ion of the effectiveness of the dosing strategy. Under these circumstances it is very difficult ? for ~e physician to determine the effectiveness of the dosing strategy.
30 - By pr~viding a machine constructed in accoraance with ' :~
' .
the present invention which provides an indication of the number of demand signals generated by the patient when he activates the trigger mechanism and the number of the successful inject signals, the physician is able to determine the effectiveness of the dosing strategy without having to question the patient directly. This is particularly true when an underdose condition exists. An underdose will be reflected in the two counters by a larger demand than dosage delivery.
When an underdose condition is determined by reference to the monitors, it is possible for the physician to adjust the - machine to deliver a larger individual dose or to permit a shorter dosing ~nterval. Thus, it will be seen that the machine of the present invention will extend the range over which the adequacy of a dosing strategy can be verified.
According to one aspect of the present invention, a device for monitoring and controlling the self-administration of intravenous drug dosages administered by a motorized syringe comprises`a trigger operable by a patient to initiate an electrical demand signal indicative of a demand for a drug dosage, a first signal monitor adapted to record the total number of occasions on which a demand aignal is initiated at the trigger, a first timer for receiving the demand signal and selectively rejecting the demand signal or passing the ~and signal- as an inject signal to the syringe to activate ` the syringe, a second signal monitor adapted to record the total number of occasions on which an inject signal passes the first timer, and a second timer for receiving the inject signal which passes from the second signal monitor to activate the motorized syringe for a preselected time period.
`The apparatus of-the-present invention will be more .
~ -4-:
, 8~33 clearly understood after reference to the following detailed specification read in conjunction with the drawings wherein, Fig. 1 is a diagramma~ic representation of a ~evice for monitoring and controlling sel~-administration of intra-venous drug dosages.
In Fig. 1 of the drawings, the reference numeral 10 refers generally to a device constructed in accordance with an embodiment of the present invention. The device includes a trigger mechanism 12 which is adapted to be operated by the patient to generate an electrical demand signal in the line 14. A aemana signal counter or monitor 16 counts and records the total number of demand signals initiated by the patient.
A timer 18 receives the demand signal and selectively re-jects the demand signal or passes the demand signal as an inject signal to the line 20. A second monitor 22 records d counts the number of inject signals which pass along the : line 20. The inject signal is transmitted along a line 25 to a second timer 24 which controls the operation of a pump motor 28 by completing the driving circuit of the motor for a preselected time period. The electrically driven pump motor 28 dispenses the required individual drug dosage ~rom the reservoir 30 to an intravenous tubing 32 which leads to the patient 34.
Initially the first timer 18 is pre-set by the physician to provide a predetermined minimum dosing interval which will ensure that the patient cannot receive more than a predeter-mined maximuml drug dosage within a predetermined time intervalO
The timer is preferably adapted to control the dosage interval within the range of 0 to ~0 minutes. The individual dose is ~, 30 regulated by the duration of the setting of the second timer _5_ ' ' ' - . ' , ' .
8~33 24 which preferably has an operational range from 0 to 30 seconds.
In use, the first and second timers 18 and 24 are pre-set as previously indicated to provide a predetermined dosing interval and the individual dose which is expected to meet the patient's needs. The reservoir 30 is connected through the pump 28 to the intravenous tubing 32 which leads to the patient 34. The patient is given control of the trigger 12.
Whenever the patient requires a drug dosage, he activates the trigger 12 which generates a demand,signal in the line 14.
The counter 16 counts and records the operation of the trigger 12 and the timer 18 will pass the first signal which ` it receives as an inject signal to the line 20. The inject signal in the line 20 is counted ana recorded by the counter 22 and is passed to the timer 24 as an inject signal. The timer 24 then activates the pump motor 28 which operates for the period of time controlled by the timer 24 to dispense the required dosage.
If the patient activates the trigger 1 before the expiry of the aosing interval pre-set in the first tim~ 18, the demand signal which is generated will be counted by the first or attempt counter 16 and rejected by the timer 18.
Repeated demand signals generated by the patient activating the trigger 12 before the expiry of the dosage interval will be counted and recorded by the attempt counter 16 but will not pass to the injector syringe until after the pre-set dosing interval has elapsed. As soon as the dosing interval has elapsed, any clemand signal generated by the operation of the trigger means by the patient will pass as an inject signal to the second timer to activate the motorized syringe 28 thus ~8633 providing the required dosage to the patient.
From the ~oregoing it will be apparent that the attempt counter 16 monitors and records the total number of attempts which the patient makes to obtain a drug dosage and the inject counter 22 monitors and records ~e total number of injections which the patient has received.
I have found that by analyzing the output from the counters 16 and 22 as previousl~ described, valuable infor-mation can be ob-tained.
iO The trigger mechanism may be in the form of a con-ventional switch mechanism such as a push button switch.
The counters 16 and 18 may be in the form of a con-ventional counter such as those manufactured by Hecon Co. Can. Inc, ana sold under the Trade Name Hecon Series 404, Totali~er.
The timers 18 and 24 may be conventional timers such as those manufactured by G & W Eagle Signal, Industrial Division and sold under the Trade Name "Cycl-Flex" Reset Timers The motorized syringe may be in the form of a non-battery driven electric motor pump such as that manufactured by Extramedic Corporation and sold under the Trade Name Holtex pump (modified) . .
. . .
1 .
., , ' ' .
. .
PRIOR ART
Several instruments have been developed for the pur-poses of permitting a patient to control the rate of adminis-tration of drug dosages by an intravenous injection system.
Motorized syringes capable of injecting a predetermined drug dosage in response to the receipt of an electrical signal are known. Examples of such motorized syringes are those sold under the trade name CARDIF PALLITOR and manufactured by Pye Electronics Limited.
In previously known devices for monitoring and con-trolling the operation of a motorized syringe, a trigger is provided which the patient can operate to generate a demand signal and a timer is provided for recèiving the demand signal and selectively rejecting the demand signal or passing the demand signal as an inject signal to the motorized syringe and-a single counter is provided. In one such prior device the counter counts the total number of occasions on which the ~0 trigger is activated. In another device the single counter counts the total number of occasions on which the timer passes the demand signal as an inject signal.
Generally it has been the practice to monitor the total number of inject signals as this serves to give the phvsician an indication of ~e total amount of drug which has been administered to the patient.
, In order to control the level of pain which a patient experiences, :it is necessarv to maintain a certain drug level ~ in the patienl:'s blood. When drugs are administered bY a ; 30 physician or a nurse, it is necessary tQ maintain a dosing , -2- !~
~B~;:33 interval of the order of thr~e to four hours. As a result of this_practice, the initial blood level will be high and will decline progressively over the balance of the dosing i~terval. Thus, the patient initially receives an overdose of the drug which will decline and become an underdose toward the end of the dosing interval. It is well known that there are two techniques by which the high swing in blood level con-centration may be reduced. One! method is to employ drugs which have a long half-life and the other is to reduce the individual dosages and to shorten the dosing intervals. The use of analgesics which have a long half-life, such as mor phine, makes it essential that the correct individual dosage for a particular patient be accurately determined because the patient's metabolism will require several hours to correct any such errors. In the alternative, where the dosage inter val is to be shortened in order to reduce the blood level concentration swings, it is necessary to employ a machine ~-~ich permits self-administration of drug dosages.
The previously known machines used for the self-administration of drug dosages permit a reduction in the size - of the individual dose and a shortening of the dosing inter-vals. The effectiveness of the dosing strategy is, however, - determined by the physiciàn as a result of consultations with the patient. There are many circumstances under which a physician is unable to communicate with a patient in order to obtain an indica~ion of the effectiveness of the dosing strategy. Under these circumstances it is very difficult ? for ~e physician to determine the effectiveness of the dosing strategy.
30 - By pr~viding a machine constructed in accoraance with ' :~
' .
the present invention which provides an indication of the number of demand signals generated by the patient when he activates the trigger mechanism and the number of the successful inject signals, the physician is able to determine the effectiveness of the dosing strategy without having to question the patient directly. This is particularly true when an underdose condition exists. An underdose will be reflected in the two counters by a larger demand than dosage delivery.
When an underdose condition is determined by reference to the monitors, it is possible for the physician to adjust the - machine to deliver a larger individual dose or to permit a shorter dosing ~nterval. Thus, it will be seen that the machine of the present invention will extend the range over which the adequacy of a dosing strategy can be verified.
According to one aspect of the present invention, a device for monitoring and controlling the self-administration of intravenous drug dosages administered by a motorized syringe comprises`a trigger operable by a patient to initiate an electrical demand signal indicative of a demand for a drug dosage, a first signal monitor adapted to record the total number of occasions on which a demand aignal is initiated at the trigger, a first timer for receiving the demand signal and selectively rejecting the demand signal or passing the ~and signal- as an inject signal to the syringe to activate ` the syringe, a second signal monitor adapted to record the total number of occasions on which an inject signal passes the first timer, and a second timer for receiving the inject signal which passes from the second signal monitor to activate the motorized syringe for a preselected time period.
`The apparatus of-the-present invention will be more .
~ -4-:
, 8~33 clearly understood after reference to the following detailed specification read in conjunction with the drawings wherein, Fig. 1 is a diagramma~ic representation of a ~evice for monitoring and controlling sel~-administration of intra-venous drug dosages.
In Fig. 1 of the drawings, the reference numeral 10 refers generally to a device constructed in accordance with an embodiment of the present invention. The device includes a trigger mechanism 12 which is adapted to be operated by the patient to generate an electrical demand signal in the line 14. A aemana signal counter or monitor 16 counts and records the total number of demand signals initiated by the patient.
A timer 18 receives the demand signal and selectively re-jects the demand signal or passes the demand signal as an inject signal to the line 20. A second monitor 22 records d counts the number of inject signals which pass along the : line 20. The inject signal is transmitted along a line 25 to a second timer 24 which controls the operation of a pump motor 28 by completing the driving circuit of the motor for a preselected time period. The electrically driven pump motor 28 dispenses the required individual drug dosage ~rom the reservoir 30 to an intravenous tubing 32 which leads to the patient 34.
Initially the first timer 18 is pre-set by the physician to provide a predetermined minimum dosing interval which will ensure that the patient cannot receive more than a predeter-mined maximuml drug dosage within a predetermined time intervalO
The timer is preferably adapted to control the dosage interval within the range of 0 to ~0 minutes. The individual dose is ~, 30 regulated by the duration of the setting of the second timer _5_ ' ' ' - . ' , ' .
8~33 24 which preferably has an operational range from 0 to 30 seconds.
In use, the first and second timers 18 and 24 are pre-set as previously indicated to provide a predetermined dosing interval and the individual dose which is expected to meet the patient's needs. The reservoir 30 is connected through the pump 28 to the intravenous tubing 32 which leads to the patient 34. The patient is given control of the trigger 12.
Whenever the patient requires a drug dosage, he activates the trigger 12 which generates a demand,signal in the line 14.
The counter 16 counts and records the operation of the trigger 12 and the timer 18 will pass the first signal which ` it receives as an inject signal to the line 20. The inject signal in the line 20 is counted ana recorded by the counter 22 and is passed to the timer 24 as an inject signal. The timer 24 then activates the pump motor 28 which operates for the period of time controlled by the timer 24 to dispense the required dosage.
If the patient activates the trigger 1 before the expiry of the aosing interval pre-set in the first tim~ 18, the demand signal which is generated will be counted by the first or attempt counter 16 and rejected by the timer 18.
Repeated demand signals generated by the patient activating the trigger 12 before the expiry of the dosage interval will be counted and recorded by the attempt counter 16 but will not pass to the injector syringe until after the pre-set dosing interval has elapsed. As soon as the dosing interval has elapsed, any clemand signal generated by the operation of the trigger means by the patient will pass as an inject signal to the second timer to activate the motorized syringe 28 thus ~8633 providing the required dosage to the patient.
From the ~oregoing it will be apparent that the attempt counter 16 monitors and records the total number of attempts which the patient makes to obtain a drug dosage and the inject counter 22 monitors and records ~e total number of injections which the patient has received.
I have found that by analyzing the output from the counters 16 and 22 as previousl~ described, valuable infor-mation can be ob-tained.
iO The trigger mechanism may be in the form of a con-ventional switch mechanism such as a push button switch.
The counters 16 and 18 may be in the form of a con-ventional counter such as those manufactured by Hecon Co. Can. Inc, ana sold under the Trade Name Hecon Series 404, Totali~er.
The timers 18 and 24 may be conventional timers such as those manufactured by G & W Eagle Signal, Industrial Division and sold under the Trade Name "Cycl-Flex" Reset Timers The motorized syringe may be in the form of a non-battery driven electric motor pump such as that manufactured by Extramedic Corporation and sold under the Trade Name Holtex pump (modified) . .
. . .
1 .
., , ' ' .
. .
Claims (2)
1. A device for monitoring and controlling the oper-ation of a motorized syringe to dispense a predetermined drug dosage comprising;
(a) trigger means operable by a patient to initiate a demand signal indicative of a demand for an individual drug dose, (b) first signal monitor means adapted to record the total number of occasions on which said demand signal is initiated by operation of said trigger means, (c) first timer means for receiving said demand signal and selectively rejecting said demand signal or emitting said demand signal as an inject signal, (d) second signal monitor means adapted to record the total number of occasions on which said first timer means emits a demand signal, (e) second timer means for receiving said inject signal, said second timer means being operable on receipt of said inject signal to activate said motorized syringe for a preselected time period to dispense a predetermined individual dose of drug.
(a) trigger means operable by a patient to initiate a demand signal indicative of a demand for an individual drug dose, (b) first signal monitor means adapted to record the total number of occasions on which said demand signal is initiated by operation of said trigger means, (c) first timer means for receiving said demand signal and selectively rejecting said demand signal or emitting said demand signal as an inject signal, (d) second signal monitor means adapted to record the total number of occasions on which said first timer means emits a demand signal, (e) second timer means for receiving said inject signal, said second timer means being operable on receipt of said inject signal to activate said motorized syringe for a preselected time period to dispense a predetermined individual dose of drug.
2. A device for monitoring and controlling self-administration of intravenous drug dosages comprising;
(a) drug dispensing means operable to dispense a drug dosage to a patient, (b) trigger means operable by a patient to initiate a demand signal indicative of a patient's demand for a drug dosage, (c) first signal monitor means adapted to record the total number of occasions on which said demand signal is initiated by operation of said trigger means, (d) first timer means for receiving said demand signal and selectively rejecting said demand signal or emitting said demand signal as an inject signal, (e) second signal monitor means adapted to record the total number of occasions on which an inject signal is emitted by said first timer, (f) second timer means for receiving the inject signal, said second timer means being operable on receipt of an inject signal to activate said drug dispensing means for a pre-selected time period to dispense a predetermined individual dose of said drug.
(a) drug dispensing means operable to dispense a drug dosage to a patient, (b) trigger means operable by a patient to initiate a demand signal indicative of a patient's demand for a drug dosage, (c) first signal monitor means adapted to record the total number of occasions on which said demand signal is initiated by operation of said trigger means, (d) first timer means for receiving said demand signal and selectively rejecting said demand signal or emitting said demand signal as an inject signal, (e) second signal monitor means adapted to record the total number of occasions on which an inject signal is emitted by said first timer, (f) second timer means for receiving the inject signal, said second timer means being operable on receipt of an inject signal to activate said drug dispensing means for a pre-selected time period to dispense a predetermined individual dose of said drug.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US109,928 | 1980-01-07 | ||
| US06/109,928 US4275727A (en) | 1980-01-07 | 1980-01-07 | Device for monitoring and controlling self-administered intravenous drug dosage |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1148633A true CA1148633A (en) | 1983-06-21 |
Family
ID=22330327
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000365323A Expired CA1148633A (en) | 1980-01-07 | 1980-11-24 | Device for monitoring and controlling self- administered intravenous drug dosage |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US4275727A (en) |
| CA (1) | CA1148633A (en) |
| GB (1) | GB2066669B (en) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4498843A (en) * | 1982-08-02 | 1985-02-12 | Schneider Philip H | Insulin infusion pump |
| EP0107150B2 (en) * | 1982-10-18 | 1992-04-15 | Siemens Aktiengesellschaft | Medicine-delivering apparatus |
| US4826810A (en) * | 1983-12-16 | 1989-05-02 | Aoki Thomas T | System and method for treating animal body tissues to improve the dietary fuel processing capabilities thereof |
| US4551133A (en) * | 1984-04-16 | 1985-11-05 | American Hospital Supply Corporation | Patient controlled medication infusion system |
| US4884013A (en) * | 1988-01-15 | 1989-11-28 | Sherwood Medical Company | Motor unit for a fluid pump and method of operation |
| US4943279A (en) * | 1988-09-30 | 1990-07-24 | C. R. Bard, Inc. | Medical pump with infusion controlled by a detachable coded label |
| ZA958073B (en) * | 1994-09-28 | 1996-04-23 | Anthony William Manicom | Method of and apparatus for administering a drug to a patient |
| RU2181299C2 (en) | 1996-02-23 | 2002-04-20 | Ново Нордиск А/С | Syringe with electronic parameter presentation |
| US6045513A (en) * | 1998-05-13 | 2000-04-04 | Medtronic, Inc. | Implantable medical device for tracking patient functional status |
| US6807965B1 (en) * | 1998-06-03 | 2004-10-26 | Scott Laboratories, Inc. | Apparatus and method for providing a conscious patient relief from pain and anxiety associated with medical or surgical procedures |
| US6663602B2 (en) | 2000-06-16 | 2003-12-16 | Novo Nordisk A/S | Injection device |
| CN100563744C (en) * | 2002-10-03 | 2009-12-02 | 斯科特实验室公司 | Be used for providing the system of trend analysis at calm and analgesic systems |
| CN1719999B (en) | 2002-10-03 | 2010-06-16 | 斯科特实验室公司 | Systems and methods for providing sensor fusion |
| EP1804865B1 (en) | 2004-10-21 | 2009-09-30 | Novo Nordisk A/S | Dial-down mechanism for wind-up pen |
| US20090043264A1 (en) | 2005-04-24 | 2009-02-12 | Novo Nordisk A/S | Injection Device |
| EP1996259B1 (en) * | 2006-03-10 | 2012-08-15 | Novo Nordisk A/S | An injection device and a method of changing a cartridge in the device |
| EP1996260B1 (en) * | 2006-03-10 | 2015-09-23 | Novo Nordisk A/S | An injection device having a gearing arrangement |
| ATE458517T1 (en) | 2006-05-16 | 2010-03-15 | Novo Nordisk As | TRANSMISSION MECHANISM FOR AN INJECTION DEVICE |
| JP5253387B2 (en) | 2006-05-18 | 2013-07-31 | ノボ・ノルデイスク・エー／エス | Injection device with mode locking means |
| AU2008231897B2 (en) | 2007-03-23 | 2012-11-29 | Novo Nordisk A/S | An injection device comprising a locking nut |
| US8986253B2 (en) | 2008-01-25 | 2015-03-24 | Tandem Diabetes Care, Inc. | Two chamber pumps and related methods |
| US8408421B2 (en) | 2008-09-16 | 2013-04-02 | Tandem Diabetes Care, Inc. | Flow regulating stopcocks and related methods |
| US8650937B2 (en) | 2008-09-19 | 2014-02-18 | Tandem Diabetes Care, Inc. | Solute concentration measurement device and related methods |
| EP2724739B1 (en) | 2009-07-30 | 2015-07-01 | Tandem Diabetes Care, Inc. | Portable infusion pump system |
| MX2014007375A (en) | 2011-12-29 | 2014-08-22 | Novo Nordisk As | Torsion- spring based wind-up autoinjector pen with dial - up/dial - down dosing mechanism. |
| US9180242B2 (en) | 2012-05-17 | 2015-11-10 | Tandem Diabetes Care, Inc. | Methods and devices for multiple fluid transfer |
| US9173998B2 (en) | 2013-03-14 | 2015-11-03 | Tandem Diabetes Care, Inc. | System and method for detecting occlusions in an infusion pump |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3871361A (en) * | 1974-03-11 | 1975-03-18 | Dean L Kamen | Control device for a monitor supervising a patient |
| US4078562A (en) * | 1976-08-16 | 1978-03-14 | Diana W. Friedman | Infusion pump with feedback control |
| US4217993A (en) * | 1977-12-02 | 1980-08-19 | Baxter Travenol Laboratories, Inc. | Flow metering apparatus for a fluid infusion system |
-
1980
- 1980-01-07 US US06/109,928 patent/US4275727A/en not_active Expired - Lifetime
- 1980-11-24 CA CA000365323A patent/CA1148633A/en not_active Expired
- 1980-12-04 GB GB8038842A patent/GB2066669B/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB2066669B (en) | 1983-08-03 |
| GB2066669A (en) | 1981-07-15 |
| US4275727B1 (en) | 1985-11-05 |
| US4275727A (en) | 1981-06-30 |
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