CA1312520C - Catheter assembly - Google Patents
Catheter assemblyInfo
- Publication number
- CA1312520C CA1312520C CA000604624A CA604624A CA1312520C CA 1312520 C CA1312520 C CA 1312520C CA 000604624 A CA000604624 A CA 000604624A CA 604624 A CA604624 A CA 604624A CA 1312520 C CA1312520 C CA 1312520C
- Authority
- CA
- Canada
- Prior art keywords
- transducer
- array
- bore
- conductors
- longitudinally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
- G01L19/14—Housings
- G01L19/141—Monolithic housings, e.g. molded or one-piece housings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/021—Measuring pressure in heart or blood vessels
- A61B5/0215—Measuring pressure in heart or blood vessels by means inserted into the body
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
- G01L19/0061—Electrical connection means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
- G01L19/0061—Electrical connection means
- G01L19/0084—Electrical connection means to the outside of the housing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L19/00—Details of, or accessories for, apparatus for measuring steady or quasi-steady pressure of a fluent medium insofar as such details or accessories are not special to particular types of pressure gauges
- G01L19/14—Housings
- G01L19/148—Details about the circuit board integration, e.g. integrated with the diaphragm surface or encapsulation
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
Abstract of the Disclosure A compact catheter assembly provides for the communication of a reference pressure to a pressure-sensing transducer by forming a passageway between spaced electrical conductors mounted on a planar dielec-tric substrate. The catheter assembly also provides for the operative mounting of multiple transducers onto a single catheter tip by employing a plurality of planar dielectric substrates, each having an array of electri-cal conductors, stacked atop one another so as to protrude longitudinally from the end of the catheter bore at different distances. A plurality of electrical transducers protrude longitudinally in series from the bore overlying the substrates.
Description
13~2~
C~TH~TER ASSEMBLY
Background of the Invention The present invention relates to a catheter assembly insertable into a living body for biophysical (e.g. blood pressure or flow rate) or biochemical ~e.g. blood pH or oxygen concentration) sensing at a region of interest. More particularly/ the inven~ion relates to compact configurations for such a catheter assembly adapting it for insertion through or into exceptionally small spaces, and for measuring multiple parameters simultaneously without sacrificing compactness.
Many prior art catheter assemblies, such as those shown in Mizuno et al., U.S. Patent No~ 4,274,423, DeRossi et al., U.S. Patent No. 4,456,013, Adams et al., U.S. Patent No. 4,683,757 and Ligtenberg et al., U.S.
Patent No. 4,722,348, employ solid-state electronic pressure transducers at their insertable ends. Such transducers have a pressure-sensing diaphragm, one side of which is exposed to the pressure to be measured and the other side of which communicates with a reference pressure passageway which extends into the catheter tube and is isolated from the pressure to be measured. To provide the reference pressure passageway, a special mounting structure for the pressure transducer must be included at the insertable end of the catheter assembly, increasing the transverse cross-sectional diameter o~
the insertable end and limiting the ~unctions which it can perform within the available space.
~3~2~?~
Other types of transducers which are conventionally employed in catheter assemblies are those categorized generally as chemically sensitive semicon-ductor devices, or C~EMFETS. These solid-state elec-S tronic chemical transducers are capable of performingchemical analysis of blood and other fluids by ion detection, and measuring pH, gases, humidity, enzymes and other parameters. Despite the variety of available transducers r however, catheters usually employ only a single solid-state device at their insertable ends for measuring a single parameter, such as pressure. Such single-function devices re~uire the sequential removal and insertion of multiple catheters having different transducers to obtain substantially contemporaneous readings of multiple parameters at a region of interest, but such multiple insertions increase the risk of injury to the patient as well as the time and expense of the procedure. Also, multiple insertions cannot simultan-eously measure multiple parameters at an identical site to correlate exactly the relationship between the param-eters. Although multi-function cathether assemblies having multiple transducers at their insertable ends have also been used in the past, such catheter assemblies have been limited with respect to their number of multi-ple functions primarily by space limitations affectingthe maximum permissible transverse cross-sectional dimension of their insertable tips, dictated by the small areas of the blood vessels or other passageways into which the tips must be inserted.
:L 3 ~
Therefore, a need exists for catheter assemblies having an insertable tip of minimized transverse cross-section, yet capable of measuring pressure and simultaneously measuring multiple parameters~
Summary_of the Invention In accordance with the preferred embodiment the invention provides a medical diagnostîc device incorporatPd an elongate catheter having an elongate interior bore and an end for insertion into a living body. A planar dielectric substrate is attached to the catheter so as to protrude longitudinally outwardly from the interior bore at the end of the catheter. A
plurality of electrical conductors are mounted longitudinally on the substrate in a transversely spac~d array protruding from the substrate and in a direction normal to the plane thereof so as to define a longitudinal passageway between adjacent conductors.
The conductor array has an exterior end protruding longitudinally outwardly from the bore of the catheter. A pressure-sensing transducer having a pressure-sensing diaphragm with respect to inner and outer sides is provided. The transducer is mounted on the conductor array so as to protrude longitudinally outwardly from the bore of the catheter with the inner side of the diaphragm in communication with th2 passageway defined by the conductor array. Means are provided for connecting the passage-way with the catheter's bore and isolating t~e passageway fromthe outer side of the diaphragm.
A portion of the conductor array may extend into the catheter's bore, in which case the transverse spacing between the conductors is preferably greater in the portion of the conductor array which protrudes longitudinally outwardly from the cathe-ter's bore than in the portion of the conductor array which extends into the catheter's bore.
A plurality of bond pads may be provided on the transducer, attached operatively to the conductor array. The device may further include means defining an aperture in the dielectric substrate for providing access for attaching the conductors to the bond pads.
The invention further provides a medical diagnostic device incorporating an elongate catheter having an elongate r~ - 3 a interior bore and an end for insertion into a living body. A
plurality of planar dielectric substrates are provided in parallel relation one above the other and protruding longitudi-nally at different distances outwardly from the end of the catheter. A plurality of arrays of electrical conductors are also provided, each conductor array being mounted longitudinally on a respective one of the dielectric substrates. Respective first and second electrical transducers protrude longitudinally in series outwardly from the end of the ca1:heter. Each trans-ducer overlies a dielectric substrate and is operatively coupledto a respective different conductor array. Advantageously, the first electrical transducer overlies both dielectric substrates and the second electrical transducer overlies one, but not the other, of the dielectric substrates. The first and second transducers preferably both intersect a common plane parallel to the planar dielectric substrates.
A third electrical transducer may be provided to overlie one of the dielectric substrates and to protrude outwardly from the catheter's end longitudinally in series with the first and second transducers. The third transducer and at least one of the first and second transducers both intersect the common plane parallel to the planar dielectric ~ubstrates.
Preferably, at least one o~ the transducers and at least one of the dielectric substrates both intersect the common plane parallel to the planar dielectric substrates~
The array of electrical conductors mounted on at least one of the substrates may be coupled to a respective transducer overlying the substrate by extending from beneath that transducer longitudinally outwardly beyond that transducer's outward extremity and reversing directions so as to overlie that transducer.
Brief DescriPtion of the Drawinqs FIG. l is a side elevational view of an exemplary embodiment of a catheter assembly of the present invention.
FIG. 2 is an enlarged plan view, partially cut away, taken along line 2-2 of FIG. l illustrating the interconnection between the substrate-mounted conductors and electrical cables within the catheter bore.
~. Ir ~
~3~2~2~
FIG. 3 is an enlarged plan view of the dielectric substrate and associated conductor array as it emerges from the insertable end of the catheter of FIG. 1.
FIG. 4a is an enlarged partially sectional plan view taken along line 4a-4a of FXG. 1 showing an embodiment of a single-transducer catheter tip according to the present invention.
FIG. 4b is an enlarged partially sectional side view of the catheter tip of FIG. 4a.
FIG. 5a is an enlarged plan view showing an embodiment of a dual-transducer catheter tip according to the present invention.
; FIG. 5b is an enlarged side view of the catheter tip of FIG. 5a.
FIG. 6a is an enlarged plan view showing an embodiment of a three-transducer catheter tip according to the present invention.
FIG. 6b is an enlarged side view of the catheter tip of FIG. 6a.
Description of the Preferred Embodiment Referring to the drawings, and in particular to FIG. 1, a preferred embodiment of the present inven-tion is shown as comprising a catheter assembly 10having a catheter tube 12, circuitry module 14 and electrical connector cable 16. The catheter 12 is preferably composed of polyurethane material of the type disclosed, for example, in U.S. Patents Nos. 4,~7,590 ~2~
and 4,523,005. The catheter includes a tip 18 at one end thereof for insertion into a living body, the tip containing one or more solid-state transducers, each for the direct measurement in vivo of a desired parameker at a region of interest. The transducerr, may be of any type requiring electrical connections, and nor~ally will employ semiconductor material constructed ~or developing an electrical signal representative of the parameter to iO be monitored. ~he signal is conducted to detector circuitry 20 through an interior catheter bore 22 extending axially through thP length of the catheter 12.
In one embodiment of the present invention, illustrated in FIGS. 2, 3, 4a and 4b, the catheter assembly 10 employs a tip 18 having a single, elongate, planar dielectric substrate 24 which protrudes longitudinally outwardly from the bore 22 at the end of the catheter 12, as shown in FI&~ 3. The substrate is preferably made of a ~lexible polyimide material and has a plurality of electrical conductors 26 con~igured longitudinally by standard photolithographic techniques in a transv rsely spaced array protruding perpendicularly to the plane of the substrate. Portions o~ the substrate 24 and conductors 26 preferably extend into the bore as far as an interconnection, sh~wn in FIG. 2, between the substrate-mounted conductors 26 and coaxial cables 23 electrically joined to the detector circuitry 20. As shown in FIGS. 3 and 4a, the transverse spaclng between the conductors 26 as they protrude ~ 3 ~
outwardly from ~he end of the bore 22 is greater than the spacing of the conductors extending into the bore.
A pressure sensing transducer 28 is operatively mounted atop the protruding portions of the conductors and substrate so as to overlie both. Each of a plurality of bond pads 30 on the transducer are thermosonically bonded to a respective conductor 26, access for such bonding being provided by an aperture 32 cut into the substrate 24. Normally the bond pads 30 are of aluminum or gold, aluminum being preferable for economy of manu-facture, while the conductors 26 are of gold-plated copperO A polyimide plate 33 (FIG~ 4b) is adhered to the bottom of the substrate to close the aperture 32 following bonding. The transducer 28 includes a presssure sensitive diaphragm 34 having an inner side 34a and an outer side 34b. The inner side 34a of the diaphragm is exposed to one or more passageways 21 defined between adjacent conductors 26, which serve as reference pressure passageways. Each of the passageways 21 is sealed from exposure to pressure on the outer side 34b of the diaphragm by the plate 33 and by an epoxy or other high-viscosity sealant layer 36 (FIGo 4b) at the end o the bore 22 where the substrate and conductors emerge therefrom. The tip is preferably completed by applying a pliable layer of polyurethane 38, which may be of the type employed in the catheter tube, onto the perimeter of tip 18, such layer being sufficiently flexible to permit the outer side 34b of the diaphragm to sense external pressure. The polyurethane also ~3~2~
seals the outer extremities of the passageways 21 from exposure to the sensed external pressure. Both the epoxy adheslve 36 and the polyurethane 38, when liquid, are sufficiently viscous to avoid wic~ing into the passageways 21 and obstructing them.
In an alternative embodiment: of the present invention shown in FIGS. 5a and 5b, catheter tip 18' includes dual elongate, planar dielectric substrates 40, 42 stacked in parallel, back-to-back relation to each other, the substrates protruding lcngitudinally at dif-ferent distances outwardly from the end of the bore 22 A respective array of electrical conductors 44, 46 is ~ounted longitudinally to each of the respective sub-: strates 40, 42. A pressure sensing transducer 28 is mounted, as described previously, atop the conductors44 overlying substrate 40 and having one side of its diaphragm 34 exposed to passageways 21' between the conductors. A solid-state chemical transducer 48 is positioned longitudinally in series to transducer 28, in end-to-end relation thereto and overlying substrate 42 so as to protrude longitudinally outwardly from the end of cathether 12 to a greater extent than transducer 28.
Both transducers 28 and 48 overlap each other verti-cally, intersecting a common plane parallel to the substrates 40, 42 and thereby requiring no significant increase in the transverse cross-sectional diameter of the tip from that required for the single-function tip ; of FIGS. 4a and 4b. The transducer 28 is operatively coupled to the array of conductors 4~ as previously ~3~2~
described, with the exception that substrate 42 serves to close the aperture 32' in lieu of the plate 33, and transducer 48 closes the ends of passageways 21'. The transducer 48 is adhered by epoxy directly atop sub-strate 42 with bond pads 30 outwardly directed. Thearray of conductors 46 are coupled to the pads 30 of transducer 4~ by extension of the conductors from beneath the transducer 48 beyond the outward extremity thereof, reversing direction so as to overlie the transducer 48.
In a third embodiment of the present invention shown in FIGS. 6a and 6b a catheter tip 1~" includes three elongate, planar dielectric substrates 40, 42, 50 stacked in parallel relation to each other and protrud-ing longitudinally at different distances outwardly fromthe end of bore 22. Substrates 40 and 42, their arrays of conductors 44 and 46, and their transducers 28 and 48 are arranged identically to FIGS. 5a and 5b. ~owever, an additional solid-state chemical transducer 54 over-lies the substrate 40 so as to be positioned longi-tudinally in series with the other two transducers.
Transducer 54 has bond pads 30 connected to conductors 52 on substrate 50 which extend upwardly from substrate 50 to the pads. The transducers 28, 48, and 54 all ; 25 overlap each other vertically so as to intersect a com-mon plane parallel to substrates 40, 42, 50 and thereby require no significant increase in the transverse cross-sectional diameter of tip 18", as compared to tips 18 and 18', despite the fact that tip 18" is capable of ~3~ 2~
performing three measurement functions simultaneously.
Comparable stacking of additional substrates and serial positioning of additional transducers at different degrees of protrusion from the catheter bore can be employed to provide still greater numbers of functions while retaining the compact configurat:ion of the tip.
The passageways 21' in FIGSo 5a, 5b, 6a and 6b are sealed from the outer side 34b of the diaphragm 34 as previously described with reference to FIGS. 4a and 4b by epoxy sealant 36' and 36", respectively. If a pliable layer 38' or 38" is employed over the chemical transducers 48 and 54, it should be sufficiently per-meable to ions to avoid any interference with the operation of the chemical transducers.
The terms and expressions which have been employed in the foregoing abstract and specifiction are used therein as terms of description and not of limita-tion, and there is no intention in the use of such terms and expressions of excluding equivalents of the features shown and described or portions thereof, it being recogni~ed that the scope of the invention is defined and limited only by the claims which ollow.
C~TH~TER ASSEMBLY
Background of the Invention The present invention relates to a catheter assembly insertable into a living body for biophysical (e.g. blood pressure or flow rate) or biochemical ~e.g. blood pH or oxygen concentration) sensing at a region of interest. More particularly/ the inven~ion relates to compact configurations for such a catheter assembly adapting it for insertion through or into exceptionally small spaces, and for measuring multiple parameters simultaneously without sacrificing compactness.
Many prior art catheter assemblies, such as those shown in Mizuno et al., U.S. Patent No~ 4,274,423, DeRossi et al., U.S. Patent No. 4,456,013, Adams et al., U.S. Patent No. 4,683,757 and Ligtenberg et al., U.S.
Patent No. 4,722,348, employ solid-state electronic pressure transducers at their insertable ends. Such transducers have a pressure-sensing diaphragm, one side of which is exposed to the pressure to be measured and the other side of which communicates with a reference pressure passageway which extends into the catheter tube and is isolated from the pressure to be measured. To provide the reference pressure passageway, a special mounting structure for the pressure transducer must be included at the insertable end of the catheter assembly, increasing the transverse cross-sectional diameter o~
the insertable end and limiting the ~unctions which it can perform within the available space.
~3~2~?~
Other types of transducers which are conventionally employed in catheter assemblies are those categorized generally as chemically sensitive semicon-ductor devices, or C~EMFETS. These solid-state elec-S tronic chemical transducers are capable of performingchemical analysis of blood and other fluids by ion detection, and measuring pH, gases, humidity, enzymes and other parameters. Despite the variety of available transducers r however, catheters usually employ only a single solid-state device at their insertable ends for measuring a single parameter, such as pressure. Such single-function devices re~uire the sequential removal and insertion of multiple catheters having different transducers to obtain substantially contemporaneous readings of multiple parameters at a region of interest, but such multiple insertions increase the risk of injury to the patient as well as the time and expense of the procedure. Also, multiple insertions cannot simultan-eously measure multiple parameters at an identical site to correlate exactly the relationship between the param-eters. Although multi-function cathether assemblies having multiple transducers at their insertable ends have also been used in the past, such catheter assemblies have been limited with respect to their number of multi-ple functions primarily by space limitations affectingthe maximum permissible transverse cross-sectional dimension of their insertable tips, dictated by the small areas of the blood vessels or other passageways into which the tips must be inserted.
:L 3 ~
Therefore, a need exists for catheter assemblies having an insertable tip of minimized transverse cross-section, yet capable of measuring pressure and simultaneously measuring multiple parameters~
Summary_of the Invention In accordance with the preferred embodiment the invention provides a medical diagnostîc device incorporatPd an elongate catheter having an elongate interior bore and an end for insertion into a living body. A planar dielectric substrate is attached to the catheter so as to protrude longitudinally outwardly from the interior bore at the end of the catheter. A
plurality of electrical conductors are mounted longitudinally on the substrate in a transversely spac~d array protruding from the substrate and in a direction normal to the plane thereof so as to define a longitudinal passageway between adjacent conductors.
The conductor array has an exterior end protruding longitudinally outwardly from the bore of the catheter. A pressure-sensing transducer having a pressure-sensing diaphragm with respect to inner and outer sides is provided. The transducer is mounted on the conductor array so as to protrude longitudinally outwardly from the bore of the catheter with the inner side of the diaphragm in communication with th2 passageway defined by the conductor array. Means are provided for connecting the passage-way with the catheter's bore and isolating t~e passageway fromthe outer side of the diaphragm.
A portion of the conductor array may extend into the catheter's bore, in which case the transverse spacing between the conductors is preferably greater in the portion of the conductor array which protrudes longitudinally outwardly from the cathe-ter's bore than in the portion of the conductor array which extends into the catheter's bore.
A plurality of bond pads may be provided on the transducer, attached operatively to the conductor array. The device may further include means defining an aperture in the dielectric substrate for providing access for attaching the conductors to the bond pads.
The invention further provides a medical diagnostic device incorporating an elongate catheter having an elongate r~ - 3 a interior bore and an end for insertion into a living body. A
plurality of planar dielectric substrates are provided in parallel relation one above the other and protruding longitudi-nally at different distances outwardly from the end of the catheter. A plurality of arrays of electrical conductors are also provided, each conductor array being mounted longitudinally on a respective one of the dielectric substrates. Respective first and second electrical transducers protrude longitudinally in series outwardly from the end of the ca1:heter. Each trans-ducer overlies a dielectric substrate and is operatively coupledto a respective different conductor array. Advantageously, the first electrical transducer overlies both dielectric substrates and the second electrical transducer overlies one, but not the other, of the dielectric substrates. The first and second transducers preferably both intersect a common plane parallel to the planar dielectric substrates.
A third electrical transducer may be provided to overlie one of the dielectric substrates and to protrude outwardly from the catheter's end longitudinally in series with the first and second transducers. The third transducer and at least one of the first and second transducers both intersect the common plane parallel to the planar dielectric ~ubstrates.
Preferably, at least one o~ the transducers and at least one of the dielectric substrates both intersect the common plane parallel to the planar dielectric substrates~
The array of electrical conductors mounted on at least one of the substrates may be coupled to a respective transducer overlying the substrate by extending from beneath that transducer longitudinally outwardly beyond that transducer's outward extremity and reversing directions so as to overlie that transducer.
Brief DescriPtion of the Drawinqs FIG. l is a side elevational view of an exemplary embodiment of a catheter assembly of the present invention.
FIG. 2 is an enlarged plan view, partially cut away, taken along line 2-2 of FIG. l illustrating the interconnection between the substrate-mounted conductors and electrical cables within the catheter bore.
~. Ir ~
~3~2~2~
FIG. 3 is an enlarged plan view of the dielectric substrate and associated conductor array as it emerges from the insertable end of the catheter of FIG. 1.
FIG. 4a is an enlarged partially sectional plan view taken along line 4a-4a of FXG. 1 showing an embodiment of a single-transducer catheter tip according to the present invention.
FIG. 4b is an enlarged partially sectional side view of the catheter tip of FIG. 4a.
FIG. 5a is an enlarged plan view showing an embodiment of a dual-transducer catheter tip according to the present invention.
; FIG. 5b is an enlarged side view of the catheter tip of FIG. 5a.
FIG. 6a is an enlarged plan view showing an embodiment of a three-transducer catheter tip according to the present invention.
FIG. 6b is an enlarged side view of the catheter tip of FIG. 6a.
Description of the Preferred Embodiment Referring to the drawings, and in particular to FIG. 1, a preferred embodiment of the present inven-tion is shown as comprising a catheter assembly 10having a catheter tube 12, circuitry module 14 and electrical connector cable 16. The catheter 12 is preferably composed of polyurethane material of the type disclosed, for example, in U.S. Patents Nos. 4,~7,590 ~2~
and 4,523,005. The catheter includes a tip 18 at one end thereof for insertion into a living body, the tip containing one or more solid-state transducers, each for the direct measurement in vivo of a desired parameker at a region of interest. The transducerr, may be of any type requiring electrical connections, and nor~ally will employ semiconductor material constructed ~or developing an electrical signal representative of the parameter to iO be monitored. ~he signal is conducted to detector circuitry 20 through an interior catheter bore 22 extending axially through thP length of the catheter 12.
In one embodiment of the present invention, illustrated in FIGS. 2, 3, 4a and 4b, the catheter assembly 10 employs a tip 18 having a single, elongate, planar dielectric substrate 24 which protrudes longitudinally outwardly from the bore 22 at the end of the catheter 12, as shown in FI&~ 3. The substrate is preferably made of a ~lexible polyimide material and has a plurality of electrical conductors 26 con~igured longitudinally by standard photolithographic techniques in a transv rsely spaced array protruding perpendicularly to the plane of the substrate. Portions o~ the substrate 24 and conductors 26 preferably extend into the bore as far as an interconnection, sh~wn in FIG. 2, between the substrate-mounted conductors 26 and coaxial cables 23 electrically joined to the detector circuitry 20. As shown in FIGS. 3 and 4a, the transverse spaclng between the conductors 26 as they protrude ~ 3 ~
outwardly from ~he end of the bore 22 is greater than the spacing of the conductors extending into the bore.
A pressure sensing transducer 28 is operatively mounted atop the protruding portions of the conductors and substrate so as to overlie both. Each of a plurality of bond pads 30 on the transducer are thermosonically bonded to a respective conductor 26, access for such bonding being provided by an aperture 32 cut into the substrate 24. Normally the bond pads 30 are of aluminum or gold, aluminum being preferable for economy of manu-facture, while the conductors 26 are of gold-plated copperO A polyimide plate 33 (FIG~ 4b) is adhered to the bottom of the substrate to close the aperture 32 following bonding. The transducer 28 includes a presssure sensitive diaphragm 34 having an inner side 34a and an outer side 34b. The inner side 34a of the diaphragm is exposed to one or more passageways 21 defined between adjacent conductors 26, which serve as reference pressure passageways. Each of the passageways 21 is sealed from exposure to pressure on the outer side 34b of the diaphragm by the plate 33 and by an epoxy or other high-viscosity sealant layer 36 (FIGo 4b) at the end o the bore 22 where the substrate and conductors emerge therefrom. The tip is preferably completed by applying a pliable layer of polyurethane 38, which may be of the type employed in the catheter tube, onto the perimeter of tip 18, such layer being sufficiently flexible to permit the outer side 34b of the diaphragm to sense external pressure. The polyurethane also ~3~2~
seals the outer extremities of the passageways 21 from exposure to the sensed external pressure. Both the epoxy adheslve 36 and the polyurethane 38, when liquid, are sufficiently viscous to avoid wic~ing into the passageways 21 and obstructing them.
In an alternative embodiment: of the present invention shown in FIGS. 5a and 5b, catheter tip 18' includes dual elongate, planar dielectric substrates 40, 42 stacked in parallel, back-to-back relation to each other, the substrates protruding lcngitudinally at dif-ferent distances outwardly from the end of the bore 22 A respective array of electrical conductors 44, 46 is ~ounted longitudinally to each of the respective sub-: strates 40, 42. A pressure sensing transducer 28 is mounted, as described previously, atop the conductors44 overlying substrate 40 and having one side of its diaphragm 34 exposed to passageways 21' between the conductors. A solid-state chemical transducer 48 is positioned longitudinally in series to transducer 28, in end-to-end relation thereto and overlying substrate 42 so as to protrude longitudinally outwardly from the end of cathether 12 to a greater extent than transducer 28.
Both transducers 28 and 48 overlap each other verti-cally, intersecting a common plane parallel to the substrates 40, 42 and thereby requiring no significant increase in the transverse cross-sectional diameter of the tip from that required for the single-function tip ; of FIGS. 4a and 4b. The transducer 28 is operatively coupled to the array of conductors 4~ as previously ~3~2~
described, with the exception that substrate 42 serves to close the aperture 32' in lieu of the plate 33, and transducer 48 closes the ends of passageways 21'. The transducer 48 is adhered by epoxy directly atop sub-strate 42 with bond pads 30 outwardly directed. Thearray of conductors 46 are coupled to the pads 30 of transducer 4~ by extension of the conductors from beneath the transducer 48 beyond the outward extremity thereof, reversing direction so as to overlie the transducer 48.
In a third embodiment of the present invention shown in FIGS. 6a and 6b a catheter tip 1~" includes three elongate, planar dielectric substrates 40, 42, 50 stacked in parallel relation to each other and protrud-ing longitudinally at different distances outwardly fromthe end of bore 22. Substrates 40 and 42, their arrays of conductors 44 and 46, and their transducers 28 and 48 are arranged identically to FIGS. 5a and 5b. ~owever, an additional solid-state chemical transducer 54 over-lies the substrate 40 so as to be positioned longi-tudinally in series with the other two transducers.
Transducer 54 has bond pads 30 connected to conductors 52 on substrate 50 which extend upwardly from substrate 50 to the pads. The transducers 28, 48, and 54 all ; 25 overlap each other vertically so as to intersect a com-mon plane parallel to substrates 40, 42, 50 and thereby require no significant increase in the transverse cross-sectional diameter of tip 18", as compared to tips 18 and 18', despite the fact that tip 18" is capable of ~3~ 2~
performing three measurement functions simultaneously.
Comparable stacking of additional substrates and serial positioning of additional transducers at different degrees of protrusion from the catheter bore can be employed to provide still greater numbers of functions while retaining the compact configurat:ion of the tip.
The passageways 21' in FIGSo 5a, 5b, 6a and 6b are sealed from the outer side 34b of the diaphragm 34 as previously described with reference to FIGS. 4a and 4b by epoxy sealant 36' and 36", respectively. If a pliable layer 38' or 38" is employed over the chemical transducers 48 and 54, it should be sufficiently per-meable to ions to avoid any interference with the operation of the chemical transducers.
The terms and expressions which have been employed in the foregoing abstract and specifiction are used therein as terms of description and not of limita-tion, and there is no intention in the use of such terms and expressions of excluding equivalents of the features shown and described or portions thereof, it being recogni~ed that the scope of the invention is defined and limited only by the claims which ollow.
Claims (10)
1. A medical diagnostic device comprising:
(a) an elongate catheter having an elongate interior bore and an end for insertion into a living body;
(b) a planar dielectric substrate attached to said catheter so as to protrude longi-tudinally outwardly from said interior bore at said end;
(c) a plurality of electrical conductors mounted longitudinally on said dielectric substrate in a transversely spaced array protruding from said substrate in a direction normal to the plane thereof so as to define a longitudinal passageway between adjacent conductors, said array having an exterior end protruding longi-tudinally outwardly from said bore;
(d) a pressure-sensing transducer having a pressure-sensing diaphragm with respec-tive inner and outer sides, said trans-ducer being mounted of said array of con-ductors so as to protrude longitudinally outwardly from said bore with said inner side of said diaphragm in communication with said passageway; and (e) means connecting said passageway with said bore and isolating said passageway from said outer side of said diaphragm.
(a) an elongate catheter having an elongate interior bore and an end for insertion into a living body;
(b) a planar dielectric substrate attached to said catheter so as to protrude longi-tudinally outwardly from said interior bore at said end;
(c) a plurality of electrical conductors mounted longitudinally on said dielectric substrate in a transversely spaced array protruding from said substrate in a direction normal to the plane thereof so as to define a longitudinal passageway between adjacent conductors, said array having an exterior end protruding longi-tudinally outwardly from said bore;
(d) a pressure-sensing transducer having a pressure-sensing diaphragm with respec-tive inner and outer sides, said trans-ducer being mounted of said array of con-ductors so as to protrude longitudinally outwardly from said bore with said inner side of said diaphragm in communication with said passageway; and (e) means connecting said passageway with said bore and isolating said passageway from said outer side of said diaphragm.
2. The device of claim 1 wherein a portion of said array extends into said bore, the transverse spacing between said conductors being greater in the portion of said array protruding longitudinally out-wardly from said bore than in the portion of said array extending into said bore.
3. The device of claim 1, including a plurality of bond pads on said transducer attached operatively to said array of conductors.
4. The device of claim 3, further including means defining an aperture in said dielectric substrate for providing access for attaching said conductors to said bond pads.
5. A medical diagnostic device comprising:
(a) an elongate catheter having an elongate interior bore and an end for insertion into a living body;
(b) a plurality of planar dielectric substrates in parallel relation one above the other and protruding longitudinally at different distances outwardly from said end;
(c) a plurality of arrays of electrical conductors, each array being mounted longitudinally on a respective one of said dielectric substrates; and (d) respective first and second electrical transducers protruding longitudinally in series outwardly from said end, each transducer overlying a dielectric sub-strate and being operatively coupled to a respective different array of said electrical conductors.
(a) an elongate catheter having an elongate interior bore and an end for insertion into a living body;
(b) a plurality of planar dielectric substrates in parallel relation one above the other and protruding longitudinally at different distances outwardly from said end;
(c) a plurality of arrays of electrical conductors, each array being mounted longitudinally on a respective one of said dielectric substrates; and (d) respective first and second electrical transducers protruding longitudinally in series outwardly from said end, each transducer overlying a dielectric sub-strate and being operatively coupled to a respective different array of said electrical conductors.
6. The device of claim 5 wherein said first electrical transducer overlies both of said dielectric substrates and said second electrical transducer overlies one, but not the other, of said dielectric substrates.
7. The device of claim 5 wherein said first and second electrical transducers both intersect a common plane parallel to said planar dielectric substrates.
8. The device of claim 5, further including a third electrical transducer overlying one of said dielectric substrates and protruding outwardly from said end longitudinally in series with said first and second transducers, said third transducer and at least one of said first and second transducers both intersecting a common plane parallel to said planar dielectric substrates.
9. The device of claim 5 wherein at least one of said transducers and at least one of said dielectric substrates both intersect a common plane parallel to said planar dielectric substrates.
10. The device of claim 5 wherein the array of electrical conductors mounted on at least one of said dielectric substrates is coupled to a respective trans-ducer overlying the substrate by extending from beneath the respective transducer longitudinally outwardly beyond the outward extremity of the respective trans-ducer and reversing direction so as to overlie the respective transducer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/226,857 US4815471A (en) | 1988-08-01 | 1988-08-01 | Catheter assembly |
US07/226,857 | 1988-08-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1312520C true CA1312520C (en) | 1993-01-12 |
Family
ID=22850698
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000604624A Expired - Fee Related CA1312520C (en) | 1988-08-01 | 1989-06-30 | Catheter assembly |
Country Status (4)
Country | Link |
---|---|
US (1) | US4815471A (en) |
EP (1) | EP0353880A3 (en) |
JP (1) | JPH0299034A (en) |
CA (1) | CA1312520C (en) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5050297A (en) * | 1989-09-21 | 1991-09-24 | Becton, Dickinson And Company | Method for assembly of a directly exposed catheter sensor on a support tip |
JP3134121B2 (en) | 1989-10-11 | 2001-02-13 | バクスター インターナショナル インコーポレーテッド | Intracranial pressure monitor and drainage catheter assembly |
JPH03216983A (en) * | 1990-01-22 | 1991-09-24 | Nippondenso Co Ltd | Ignition plug with pressure detector |
US5207227A (en) * | 1990-03-02 | 1993-05-04 | Powers Alexandros D | Multiprobes with thermal diffusion flow monitor |
JPH05508328A (en) * | 1990-03-02 | 1993-11-25 | パワーズ,アレクサンドロス.ディー. | Multidimensional probe with thermal diffusion flow monitor |
IE75901B1 (en) * | 1990-05-16 | 1997-10-08 | Becton Dickinson Co | Multiconductor and support and machine and method for making |
US5052105A (en) * | 1990-06-05 | 1991-10-01 | Hutchinson Technology, Inc. | Micro-cable interconnect |
DE59202616D1 (en) * | 1991-12-24 | 1995-07-27 | Landis & Gry Tech Innovat Ag | Pressure sensor with a membrane made of semiconductor material. |
US5810741A (en) * | 1992-11-05 | 1998-09-22 | Synectics Medical Ab | Method of measuring respiration and respiratory effort using plural catheters |
US5477860A (en) * | 1992-11-05 | 1995-12-26 | Synectics Medical, Inc. | Catheter for measuring respiration and respiratory effort |
US5438985A (en) * | 1993-01-25 | 1995-08-08 | Synectics Medical, Incorporated | Ambulatory recording of the presence and activity of substances in gastro-intestinal compartments |
US5551425A (en) * | 1993-05-13 | 1996-09-03 | Synectics Medical, Inc. | Potential difference and perfusion pressure catheter |
US5657759A (en) * | 1993-05-13 | 1997-08-19 | Synectics Medical, Incorporated | Measurement of gastric emptying and gastrointestinal output |
US5507289A (en) * | 1993-09-16 | 1996-04-16 | Synectics Medical, Inc. | System and method to diagnose bacterial growth |
US5477854A (en) * | 1993-09-16 | 1995-12-26 | Synectics Medical, Inc. | System and method to monitor gastrointestinal Helicobacter pylori infection |
US5833625A (en) * | 1993-10-21 | 1998-11-10 | Synectics Medical Ab | Ambulatory reflux monitoring system |
US5479935A (en) * | 1993-10-21 | 1996-01-02 | Synectics Medical, Inc. | Ambulatory reflux monitoring system |
US5517846A (en) * | 1994-02-18 | 1996-05-21 | Caggiani; Carlos A. | Electronic vacuum sensor |
DE19638813C1 (en) * | 1996-09-20 | 1998-03-05 | Sican F & E Gmbh Sibet | Measuring device for medical applications with an intracorporeally usable sensor element and method for its production |
US7455666B2 (en) | 2001-07-13 | 2008-11-25 | Board Of Regents, The University Of Texas System | Methods and apparatuses for navigating the subarachnoid space |
US8886273B2 (en) | 2003-08-01 | 2014-11-11 | Dexcom, Inc. | Analyte sensor |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US20080119703A1 (en) * | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
US8626257B2 (en) | 2003-08-01 | 2014-01-07 | Dexcom, Inc. | Analyte sensor |
US7591801B2 (en) | 2004-02-26 | 2009-09-22 | Dexcom, Inc. | Integrated delivery device for continuous glucose sensor |
US7920906B2 (en) | 2005-03-10 | 2011-04-05 | Dexcom, Inc. | System and methods for processing analyte sensor data for sensor calibration |
WO2005040744A2 (en) * | 2003-10-10 | 2005-05-06 | Sierra Scientific Instruments, Inc. | High resolution solid state pressure sensor |
US8615282B2 (en) | 2004-07-13 | 2013-12-24 | Dexcom, Inc. | Analyte sensor |
US9247900B2 (en) | 2004-07-13 | 2016-02-02 | Dexcom, Inc. | Analyte sensor |
US8425416B2 (en) | 2006-10-04 | 2013-04-23 | Dexcom, Inc. | Analyte sensor |
US11633133B2 (en) | 2003-12-05 | 2023-04-25 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US20080197024A1 (en) * | 2003-12-05 | 2008-08-21 | Dexcom, Inc. | Analyte sensor |
US8364231B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US8423114B2 (en) | 2006-10-04 | 2013-04-16 | Dexcom, Inc. | Dual electrode system for a continuous analyte sensor |
US8364230B2 (en) | 2006-10-04 | 2013-01-29 | Dexcom, Inc. | Analyte sensor |
US8425417B2 (en) * | 2003-12-05 | 2013-04-23 | Dexcom, Inc. | Integrated device for continuous in vivo analyte detection and simultaneous control of an infusion device |
US8287453B2 (en) * | 2003-12-05 | 2012-10-16 | Dexcom, Inc. | Analyte sensor |
US8808228B2 (en) | 2004-02-26 | 2014-08-19 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US7654956B2 (en) | 2004-07-13 | 2010-02-02 | Dexcom, Inc. | Transcutaneous analyte sensor |
WO2006127694A2 (en) | 2004-07-13 | 2006-11-30 | Dexcom, Inc. | Analyte sensor |
US7783333B2 (en) | 2004-07-13 | 2010-08-24 | Dexcom, Inc. | Transcutaneous medical device with variable stiffness |
US7356366B2 (en) * | 2004-08-02 | 2008-04-08 | Cardiac Pacemakers, Inc. | Device for monitoring fluid status |
US7520858B2 (en) * | 2006-06-05 | 2009-04-21 | Physical Logic Ag | Catheter with pressure sensor and guidance system |
US8298142B2 (en) * | 2006-10-04 | 2012-10-30 | Dexcom, Inc. | Analyte sensor |
US8478377B2 (en) | 2006-10-04 | 2013-07-02 | Dexcom, Inc. | Analyte sensor |
US8562528B2 (en) * | 2006-10-04 | 2013-10-22 | Dexcom, Inc. | Analyte sensor |
US8449464B2 (en) * | 2006-10-04 | 2013-05-28 | Dexcom, Inc. | Analyte sensor |
US8447376B2 (en) | 2006-10-04 | 2013-05-21 | Dexcom, Inc. | Analyte sensor |
US8275438B2 (en) * | 2006-10-04 | 2012-09-25 | Dexcom, Inc. | Analyte sensor |
US20080306434A1 (en) | 2007-06-08 | 2008-12-11 | Dexcom, Inc. | Integrated medicament delivery device for use with continuous analyte sensor |
US10842653B2 (en) | 2007-09-19 | 2020-11-24 | Ability Dynamics, Llc | Vacuum system for a prosthetic foot |
US9452258B2 (en) | 2007-10-09 | 2016-09-27 | Dexcom, Inc. | Integrated insulin delivery system with continuous glucose sensor |
US8396528B2 (en) | 2008-03-25 | 2013-03-12 | Dexcom, Inc. | Analyte sensor |
US20100114063A1 (en) * | 2008-11-04 | 2010-05-06 | Angiodynamics, Inc. | Catheter injection monitoring device |
US8069730B2 (en) | 2008-11-14 | 2011-12-06 | Kulite Semiconductor Products, Inc. | Pressure transducer structures suitable for curved surfaces |
US20100273355A1 (en) * | 2009-04-22 | 2010-10-28 | Tyco Electronics Corporation | Image guide wire connection |
US20110092955A1 (en) * | 2009-10-07 | 2011-04-21 | Purdy Phillip D | Pressure-Sensing Medical Devices, Systems and Methods, and Methods of Forming Medical Devices |
ES2847578T3 (en) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Advanced analyte sensor calibration and error detection |
EP2644103B1 (en) * | 2011-11-24 | 2016-01-13 | Olympus Corporation | Ultrasound probe |
US9703317B2 (en) * | 2013-03-14 | 2017-07-11 | Biosense Webster (Israel) Ltd. | Dongle with shape memory |
US9498300B1 (en) * | 2015-07-30 | 2016-11-22 | Novartis Ag | Communication system for surgical devices |
PT3367886T (en) * | 2015-10-29 | 2021-06-18 | Sintef Tto As | Sensor assembly |
US11331022B2 (en) | 2017-10-24 | 2022-05-17 | Dexcom, Inc. | Pre-connected analyte sensors |
CN111246797A (en) | 2017-10-24 | 2020-06-05 | 德克斯康公司 | Pre-attached analyte sensors |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4023562A (en) * | 1975-09-02 | 1977-05-17 | Case Western Reserve University | Miniature pressure transducer for medical use and assembly method |
US4201222A (en) * | 1977-08-31 | 1980-05-06 | Thomas Haase | Method and apparatus for in vivo measurement of blood gas partial pressures, blood pressure and blood pulse |
JPS5921495B2 (en) * | 1977-12-15 | 1984-05-21 | 株式会社豊田中央研究所 | Capillary pressure gauge |
IE51643B1 (en) * | 1980-10-15 | 1987-01-21 | Smith & Nephew Ass | Coated articles and materials suitable for coating |
US4456013A (en) * | 1981-09-08 | 1984-06-26 | Brown University Research Foundation | Catheter |
DE3142075A1 (en) * | 1981-10-23 | 1983-05-05 | Drägerwerk AG, 2400 Lübeck | PUNCHING PROBE |
GB2111215A (en) * | 1981-10-31 | 1983-06-29 | Alastair Sibbald | Electrochemical sensor assembly |
US4554927A (en) * | 1983-08-30 | 1985-11-26 | Thermometrics Inc. | Pressure and temperature sensor |
DE3500613A1 (en) * | 1984-03-09 | 1985-09-19 | Hans W. Dipl.-Phys. ETH Winterthur Keller | Piezo-resistive pressure-measurement cell |
DE8407322U1 (en) * | 1984-03-09 | 1984-05-30 | Keller, Hans W., Dipl.-Phys. ETH, 8404 Winterthur | PIEZORESESTIVE PRESSURE MEASURING CELL |
NL8502543A (en) * | 1985-09-17 | 1987-04-16 | Sentron V O F | ELECTRONIC PRESSURE SENSITIVE ELEMENT MADE OF SEMICONDUCTOR MATERIAL. |
US4683757A (en) * | 1986-03-24 | 1987-08-04 | Motorola, Inc. | Axial pressure sensor |
US4730622A (en) * | 1986-07-01 | 1988-03-15 | Cordis Corporation | Pressure and oxygen saturation catheter |
US4727730A (en) * | 1986-07-10 | 1988-03-01 | Medex, Inc. | Integrated optic system for monitoring blood pressure |
EP0263190A1 (en) * | 1986-10-02 | 1988-04-13 | Dräger Nederland B.V. | Pressure transducer for medical applications |
-
1988
- 1988-08-01 US US07/226,857 patent/US4815471A/en not_active Expired - Fee Related
-
1989
- 1989-06-30 CA CA000604624A patent/CA1312520C/en not_active Expired - Fee Related
- 1989-07-10 EP EP19890306999 patent/EP0353880A3/en not_active Ceased
- 1989-07-31 JP JP1197010A patent/JPH0299034A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0353880A2 (en) | 1990-02-07 |
EP0353880A3 (en) | 1991-07-24 |
JPH0299034A (en) | 1990-04-11 |
US4815471A (en) | 1989-03-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA1312520C (en) | Catheter assembly | |
US6824521B2 (en) | Sensing catheter system and method of fabrication | |
CA1326885C (en) | Encapsulated blood pressure transducer | |
EP0047986B1 (en) | Integral hermetic implantable pressure transducer | |
US5086777A (en) | Small-sized disposable pressure transducer apparatus with a temperature compensating circuit disposed adjacent a passageway coupled with a catheter | |
CA1326968C (en) | Disposable pressure transducer and disposable pressure transducer apparatus | |
US7162926B1 (en) | Lead embedded pressure sensor | |
US4722348A (en) | Catheter tip pressure transducer | |
US4685469A (en) | Piezoresistive pressure measuring cell | |
US5131400A (en) | Pulse wave detecting apparatus | |
US4576181A (en) | Disposable pressure transducer apparatus for medical use | |
EP0778746B1 (en) | Ultra miniature pressure sensor and guidewire using the same | |
US5581038A (en) | Pressure measurement apparatus having a reverse mounted transducer and overpressure guard | |
US7318264B2 (en) | Monolithic integrated circuit/pressure sensor on pacing lead | |
US5833824A (en) | Dorsal substrate guarded ISFET sensor | |
US6264612B1 (en) | Catheter with mechano-responsive element for sensing physiological conditions | |
JPS5921495B2 (en) | Capillary pressure gauge | |
EP0180662A1 (en) | Measuring transducer, in particular for medical applications | |
JP2000193546A (en) | Catheter with pressure detection mechanism | |
US20160220187A1 (en) | Sensor element with an insulation layer | |
JP3565982B2 (en) | Catheter with sensor function | |
JP2001170013A (en) | Catheter with pressure detecting function | |
EP0377943A1 (en) | Intrauterine catheter | |
JP3597942B2 (en) | Catheter with sensor function, semiconductor type physical quantity sensor chip | |
AU611324B2 (en) | Disposable pressure transducer and disposable pressure transducer apparatus |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MKLA | Lapsed |