CA1325777C - Oral compositions - Google Patents
Oral compositionsInfo
- Publication number
- CA1325777C CA1325777C CA000600005A CA600005A CA1325777C CA 1325777 C CA1325777 C CA 1325777C CA 000600005 A CA000600005 A CA 000600005A CA 600005 A CA600005 A CA 600005A CA 1325777 C CA1325777 C CA 1325777C
- Authority
- CA
- Canada
- Prior art keywords
- hydroxyapatite
- strontium
- potassium
- sodium
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Abstract
ABSTRACT OF THE DISCLOSURE
The present invention relates to oral compositions for treating sensitive teeth.
These compositions comprise an agent for desensitising sensitive teeth, such as potassium nitrate or strontium acetate, and a particulate abrasive material which is hydroxyapatite. The hydroxyapatite is compatible with the desensitising agent.
The present invention relates to oral compositions for treating sensitive teeth.
These compositions comprise an agent for desensitising sensitive teeth, such as potassium nitrate or strontium acetate, and a particulate abrasive material which is hydroxyapatite. The hydroxyapatite is compatible with the desensitising agent.
Description
~ ~32577~
J 3078 (R) ORAL COMPOSITIONS
This invention relates to oral compositions and in particular to oral compositions containing an agent ~or desensitising sensitive teeth.
It is an object of the invention to pro~ide an improved tooth desensitising composition.
.
The novel tooth desensitising oral composition of this invention comprises a combination of insoluble and soluble compounds each having a tooth desensitising action and wherein the insoluble compound also acts as a tooth cleaning and polishing agent.
Accordingly, the invention provides a tooth desensitising oral composition comprising a.finely divided hydroxyapatite and a source of pokassium and/or strontium ions.
It-is already known to use finely divided hydroxyapatite as an abrasive of an oral composition ~see CA-A-999 238, US-A-4 634 589 and US-A-4 327 079) but its us~
in products containing a source of potassium and/or strontium ions has not previously been suggested.
The hydroxyapatite abrasive i~ used in a particle size giving satisfactory cleaning without being harmful to the tooth surface when used in appropriate amounts in dentifrices of the invention. The avera~e particle size will usually be in the range from about 1 ~icron to about 15 microns, preferably 2-10 and particularly preferably about 3 to about 10 microns.
Preferred particulate hydroxyapatites for use in oral compositions of this invention are synthetic hydroxyapatites of high purity consisting o~ at least .. ~L
~ ~32577~
J 3078 (R) 92% of CalO(P04)6(0H~2- The remainder will comprise mainly bound water (typically 6% maximum) and a minor amount of calcium carbonate (typically 2% maximum). A
process for the preparation of hydroxyapatites is described in GB-A~l 586 gl5 (British Charcoals &
Macdonalds).
A highly pure synthetic hydroxyapatite available ~
commercially is that sold under the trade name CAPTAL by British Charcoals & Macdonalds of Greenock, Scotland.
This hydroxyapatite contains about 97% CalO(P04)6(OH)2~ -The remaining 3% is mostly bound water with approximately 0.3% calcium carbonate.
The amount of the hydroxyapatite present in oral compositions of this invention will range fro~ 1-50%, usually about 2% to about 20%, pre~erably 3 to 15%, by weight of the oral composition.
Various potassium and strontium compounds have been described in the literature for use a~ tooth desensitising agents. US-A-3 863 006 (Hodosh) describes the use of potassium nitrate. EP-A-95 871 ~Reckitt and Colman) discloses the use of potassium citrate.
PCT/US85J00123 (The Trustees of Columhia University in the City ot New York) discloses the use of potassium bicarbonate and potassium chloride. A further e~ective potassium compound which is disclosed in our co-pending application 8706187 is potassium acetate.
US-A-3 122 483 (Block Dru~ ro.) discloses the use of water-soluble strontium compounds as tooth desensitising agents, such as strontium chloride, strontium lactate, strontium acetate, strontium bro~ide, 5trontium iodide, strontium nitrate and strontium salicylate.
US-A-3 699 221 (Schole et al.) describes the use of a non-toxic, water-soluble ionic strontium compound .
`
~3257~
J 3078 (R) selected from the class consisting of oxganic chelating agents and inorganic sequestering agents. Examples of such agents are strontium citrate, disodium salt of ethylenediamine tetraacetic acid, strontium gluconate and strontium gentisate.
The amount of the source of potassium or strontium ions will generally be from about 1% to about 20%~ usually to about 10%, for example from 2% to 8~, more preferably 3-6~ by weight of the'oral composition.
An additional benefit which is already associated withthe use of hydroxyapatitein the prior literature is a remineralising effect on tooth material.
Together with the hydroxyapatite and the source of potassium or strontium ions, the oral product of the invention will contain other conventional ingredients well known to those skilled in art depending on the form of the oral product. For instance, in the case of an oral product in the ~orm of a dentifrice cream or paste, the product will comprise an humectant-containing liquid phase and a binder or thickener which acts to maintain the particulate solid abrasive in stable suspension in the liquid phase. A surfactant and a flavouring agent are also usual ingredients of commercially acceptable dentifrices.
EIumectants commonly used are glycerol and sorbitol syrup (usually comprising an approximately 70% solution).
However, other humectants are known to those in the art, including propylene glycol, lactitol and hydrogenated corn syrup. The amount of humectant will generally range from about 10 to 85% by weight of the dentifrice. The remainder of the liquid phase will consist substantially of water.
..
: . .
. . . .
~32~777 J 3078 (R) Likewise, numerous binding or thickening agents have been indicated for use in dentifrices, preferred ones being sodium carboxymethylcellulose and xanthan gum.
Others include natural gum binders such as gum tragacanth, gum karaya and gum arabic, Irish moss, alginates and carrageenans. Silica thickening agents include the silica aerogels and various precipitated silicas. Mixtures of binding and thickening agents may be used. The amount of binder and thickening agent included in a dentifrice is generally betw~en 0.1 and 10% by weight.
It is usual to include a surfactant in a toothpaste and again the literature discloses a wide variety o~
suitable materials. Surfactants which have found wide use in practice are sodium lauryl sulphate, sodium dodecylbenzene sulphonate and sodium lauroylsarcosinate.
Other anionic surfactants may be used as well as other types such as cationic, amphoteric and non-ionic surfactants. Surfactants are usually present in an amount of from 0.5 to 5% by weight of the dentifrice.
Flavours that are usually used in dentifrices are those based on oils of spear~int and pepper~int. Examples of other flavourinq materials used are menthol, clo~e, wintergreen, eucalyptus and aniseed. ~n amount of from 0.1~ to 5% ~y weight is a suitable amount of ~lavour to incorporate in a dentifrice.
The oral compositions of ~he invention may also comprise a proportion of a supplementary abrasive agent such as silica, alumina, hydrated alumina, calcium carbonate, anhydrous dicalcium phosphate, dicalcium phosphate dihydrate and water-insoluble sodium metaphosphate.
The oral composition of the invention may include a wide variety of optional ingredients. These include an , ~ ` . ' -, - : . ~ ., . ~ i .
: . . . .. : .
lL32~7 J 3078 (R) anti-plaque agent such as an anti~icrobial compound, for example chlorhexidine or 2,4,4'-trichloro-2'-hydroxy-diphenyl ether, or a zinc compound (see EP-A-161 898); an anti-tartar ingredient such as a condensed phosphate, e.g. an alkali metal pyrophosphate, hexametaphospha~e or polyphosphate, (see US-A-4 515 772 and US-A-4 627 977) or zinc citrate (see US-A-4 100 269): a fluorine-containing compound such as sodium fluoride or sodium mono~luorophosphate;
sweetening agPnt such as saccharin; an opacifying agent, such as titanium dioxid~, a preservative, such as formalin; a colouring agent; or pH-controlling agent such as an acid, base or buffer, such as benzoic acid.
For a fuller discussion of the formulation of oral compositions, reference is made to Harry's Cosmeticology, Seventh ~dition, 1982, Edited by J.B.
Wilkinson and R.J. Moore, pages 609 to 617.
The invention also relates to a method o~ desensitising sensitive teeth which consists in applying to the teeth, such as by brushing, an oral composition according to the invention.
The following Examples illustrate the invention.
Percentages and parks are by w~ight.
., .
~ ~32~
J 3078 (R) Example A toothpaste is prepared from the ~ollowing ingredients:
5 In ~ edient %
Hydroxyapatite 5.00 Silica aerogel (Gasil 23) 10.00 Sorbitol syrup . 40.00 Sodium lauryl sulphate 1.50 10 Sodium carboxymethylcellulose 1.00 Potassium nitrate 3.00 Sodium monofluorophosphate 0.76 Sodium saccharin 0.20 Titanium dioxide 1.00 15 Formalin 0.04 Flavour 1.00 Water to 100.00 Example 2 A toothpaste i5 prepared ~rom the following ingredients:
Inqredient Hydroxyapatite 5.00 Silica aerogel tGasil 23) 10.00 25 Sorbitol syrup 40.00 Sodium lauryl sulpha~e 1.50 Sodium carbo~ymethylcellulose 1.00 Strontiu chloride 5.00 Sodium mono~luorophosphate 0.76 30 Sodium saccharin 0.20 Titanium dioxide 1.00 Formalin 0.04 Flavour 1.00 Water to 100.00 ': , ~ 132~777 J 3078 (R) ExamPles 3 to 6 Toothpastes are made from the ingredients indicated below.
Inaredient Example: 3 4 5 6 Hydroxyapatite .10.0 10.0 5.0 5.0 Thickening silica 10.0 10.0 10.0 10.0 10 Sorbitol syrup (708 solution) 40.0 40.0 40.0 40.0 Sodium lauryl sulphate 1.5 1.5 1.5 Sodium carboxymethyl-cellulose 1.0 1.0 1~0 1.0 Potassium nitrate 3.0 - 3.0 3.0 Strontium acetate - 3.0 ~ -Sodium monofluoro-phosphate 0.8 0.8 0.8 0.8 Triclosan 0.2 - - -20 Hexetidine - 0.2 Polyethyleneglycol 300 6.0 - - -iChlorhexidine digluconate - - 0.1 0.1 Stannous chloride - - 0.4 0.4 Sodium saccharin 1.2 0.2 0.2 0.2 Titanium dioxide ~.0 1.0 1.0 1.O
Formalin 0.04 0.04 0.04 0.04 Flavour 1.0 1.0 1.0 1.0 Water all to 100.0 100.0 100.0 100.0 - : -: ` :
... .
J 3078 (R) ORAL COMPOSITIONS
This invention relates to oral compositions and in particular to oral compositions containing an agent ~or desensitising sensitive teeth.
It is an object of the invention to pro~ide an improved tooth desensitising composition.
.
The novel tooth desensitising oral composition of this invention comprises a combination of insoluble and soluble compounds each having a tooth desensitising action and wherein the insoluble compound also acts as a tooth cleaning and polishing agent.
Accordingly, the invention provides a tooth desensitising oral composition comprising a.finely divided hydroxyapatite and a source of pokassium and/or strontium ions.
It-is already known to use finely divided hydroxyapatite as an abrasive of an oral composition ~see CA-A-999 238, US-A-4 634 589 and US-A-4 327 079) but its us~
in products containing a source of potassium and/or strontium ions has not previously been suggested.
The hydroxyapatite abrasive i~ used in a particle size giving satisfactory cleaning without being harmful to the tooth surface when used in appropriate amounts in dentifrices of the invention. The avera~e particle size will usually be in the range from about 1 ~icron to about 15 microns, preferably 2-10 and particularly preferably about 3 to about 10 microns.
Preferred particulate hydroxyapatites for use in oral compositions of this invention are synthetic hydroxyapatites of high purity consisting o~ at least .. ~L
~ ~32577~
J 3078 (R) 92% of CalO(P04)6(0H~2- The remainder will comprise mainly bound water (typically 6% maximum) and a minor amount of calcium carbonate (typically 2% maximum). A
process for the preparation of hydroxyapatites is described in GB-A~l 586 gl5 (British Charcoals &
Macdonalds).
A highly pure synthetic hydroxyapatite available ~
commercially is that sold under the trade name CAPTAL by British Charcoals & Macdonalds of Greenock, Scotland.
This hydroxyapatite contains about 97% CalO(P04)6(OH)2~ -The remaining 3% is mostly bound water with approximately 0.3% calcium carbonate.
The amount of the hydroxyapatite present in oral compositions of this invention will range fro~ 1-50%, usually about 2% to about 20%, pre~erably 3 to 15%, by weight of the oral composition.
Various potassium and strontium compounds have been described in the literature for use a~ tooth desensitising agents. US-A-3 863 006 (Hodosh) describes the use of potassium nitrate. EP-A-95 871 ~Reckitt and Colman) discloses the use of potassium citrate.
PCT/US85J00123 (The Trustees of Columhia University in the City ot New York) discloses the use of potassium bicarbonate and potassium chloride. A further e~ective potassium compound which is disclosed in our co-pending application 8706187 is potassium acetate.
US-A-3 122 483 (Block Dru~ ro.) discloses the use of water-soluble strontium compounds as tooth desensitising agents, such as strontium chloride, strontium lactate, strontium acetate, strontium bro~ide, 5trontium iodide, strontium nitrate and strontium salicylate.
US-A-3 699 221 (Schole et al.) describes the use of a non-toxic, water-soluble ionic strontium compound .
`
~3257~
J 3078 (R) selected from the class consisting of oxganic chelating agents and inorganic sequestering agents. Examples of such agents are strontium citrate, disodium salt of ethylenediamine tetraacetic acid, strontium gluconate and strontium gentisate.
The amount of the source of potassium or strontium ions will generally be from about 1% to about 20%~ usually to about 10%, for example from 2% to 8~, more preferably 3-6~ by weight of the'oral composition.
An additional benefit which is already associated withthe use of hydroxyapatitein the prior literature is a remineralising effect on tooth material.
Together with the hydroxyapatite and the source of potassium or strontium ions, the oral product of the invention will contain other conventional ingredients well known to those skilled in art depending on the form of the oral product. For instance, in the case of an oral product in the ~orm of a dentifrice cream or paste, the product will comprise an humectant-containing liquid phase and a binder or thickener which acts to maintain the particulate solid abrasive in stable suspension in the liquid phase. A surfactant and a flavouring agent are also usual ingredients of commercially acceptable dentifrices.
EIumectants commonly used are glycerol and sorbitol syrup (usually comprising an approximately 70% solution).
However, other humectants are known to those in the art, including propylene glycol, lactitol and hydrogenated corn syrup. The amount of humectant will generally range from about 10 to 85% by weight of the dentifrice. The remainder of the liquid phase will consist substantially of water.
..
: . .
. . . .
~32~777 J 3078 (R) Likewise, numerous binding or thickening agents have been indicated for use in dentifrices, preferred ones being sodium carboxymethylcellulose and xanthan gum.
Others include natural gum binders such as gum tragacanth, gum karaya and gum arabic, Irish moss, alginates and carrageenans. Silica thickening agents include the silica aerogels and various precipitated silicas. Mixtures of binding and thickening agents may be used. The amount of binder and thickening agent included in a dentifrice is generally betw~en 0.1 and 10% by weight.
It is usual to include a surfactant in a toothpaste and again the literature discloses a wide variety o~
suitable materials. Surfactants which have found wide use in practice are sodium lauryl sulphate, sodium dodecylbenzene sulphonate and sodium lauroylsarcosinate.
Other anionic surfactants may be used as well as other types such as cationic, amphoteric and non-ionic surfactants. Surfactants are usually present in an amount of from 0.5 to 5% by weight of the dentifrice.
Flavours that are usually used in dentifrices are those based on oils of spear~int and pepper~int. Examples of other flavourinq materials used are menthol, clo~e, wintergreen, eucalyptus and aniseed. ~n amount of from 0.1~ to 5% ~y weight is a suitable amount of ~lavour to incorporate in a dentifrice.
The oral compositions of ~he invention may also comprise a proportion of a supplementary abrasive agent such as silica, alumina, hydrated alumina, calcium carbonate, anhydrous dicalcium phosphate, dicalcium phosphate dihydrate and water-insoluble sodium metaphosphate.
The oral composition of the invention may include a wide variety of optional ingredients. These include an , ~ ` . ' -, - : . ~ ., . ~ i .
: . . . .. : .
lL32~7 J 3078 (R) anti-plaque agent such as an anti~icrobial compound, for example chlorhexidine or 2,4,4'-trichloro-2'-hydroxy-diphenyl ether, or a zinc compound (see EP-A-161 898); an anti-tartar ingredient such as a condensed phosphate, e.g. an alkali metal pyrophosphate, hexametaphospha~e or polyphosphate, (see US-A-4 515 772 and US-A-4 627 977) or zinc citrate (see US-A-4 100 269): a fluorine-containing compound such as sodium fluoride or sodium mono~luorophosphate;
sweetening agPnt such as saccharin; an opacifying agent, such as titanium dioxid~, a preservative, such as formalin; a colouring agent; or pH-controlling agent such as an acid, base or buffer, such as benzoic acid.
For a fuller discussion of the formulation of oral compositions, reference is made to Harry's Cosmeticology, Seventh ~dition, 1982, Edited by J.B.
Wilkinson and R.J. Moore, pages 609 to 617.
The invention also relates to a method o~ desensitising sensitive teeth which consists in applying to the teeth, such as by brushing, an oral composition according to the invention.
The following Examples illustrate the invention.
Percentages and parks are by w~ight.
., .
~ ~32~
J 3078 (R) Example A toothpaste is prepared from the ~ollowing ingredients:
5 In ~ edient %
Hydroxyapatite 5.00 Silica aerogel (Gasil 23) 10.00 Sorbitol syrup . 40.00 Sodium lauryl sulphate 1.50 10 Sodium carboxymethylcellulose 1.00 Potassium nitrate 3.00 Sodium monofluorophosphate 0.76 Sodium saccharin 0.20 Titanium dioxide 1.00 15 Formalin 0.04 Flavour 1.00 Water to 100.00 Example 2 A toothpaste i5 prepared ~rom the following ingredients:
Inqredient Hydroxyapatite 5.00 Silica aerogel tGasil 23) 10.00 25 Sorbitol syrup 40.00 Sodium lauryl sulpha~e 1.50 Sodium carbo~ymethylcellulose 1.00 Strontiu chloride 5.00 Sodium mono~luorophosphate 0.76 30 Sodium saccharin 0.20 Titanium dioxide 1.00 Formalin 0.04 Flavour 1.00 Water to 100.00 ': , ~ 132~777 J 3078 (R) ExamPles 3 to 6 Toothpastes are made from the ingredients indicated below.
Inaredient Example: 3 4 5 6 Hydroxyapatite .10.0 10.0 5.0 5.0 Thickening silica 10.0 10.0 10.0 10.0 10 Sorbitol syrup (708 solution) 40.0 40.0 40.0 40.0 Sodium lauryl sulphate 1.5 1.5 1.5 Sodium carboxymethyl-cellulose 1.0 1.0 1~0 1.0 Potassium nitrate 3.0 - 3.0 3.0 Strontium acetate - 3.0 ~ -Sodium monofluoro-phosphate 0.8 0.8 0.8 0.8 Triclosan 0.2 - - -20 Hexetidine - 0.2 Polyethyleneglycol 300 6.0 - - -iChlorhexidine digluconate - - 0.1 0.1 Stannous chloride - - 0.4 0.4 Sodium saccharin 1.2 0.2 0.2 0.2 Titanium dioxide ~.0 1.0 1.0 1.O
Formalin 0.04 0.04 0.04 0.04 Flavour 1.0 1.0 1.0 1.0 Water all to 100.0 100.0 100.0 100.0 - : -: ` :
... .
Claims (5)
1. An oral composition for the treatment of sensitive teeth, comprising a source of potassium and/or strontium ions as desensitising agent, and a particulate abrasive material, wherein the particulate abrasive material is or comprises hydroxyapatite.
2. A preparation according to claim 1, wherein the hydroxyapatite has an average particle size of from 1 to 15 microns.
3. A preparation according to claim 1, wherein the hydroxyapatite is a synthetic hydroxyapatite which consists for at least 92% by weight of Ca10(PO4)6(OH)2.
4. A preparation according to claim 1, wherein the hydroxyapatite is present in an amount of 1-50% by weight.
5. A composition according to claim 1, wherein the composition comprises from 1-10% by weight of the source of the potassium and/or strontium ions as desensitising agent.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8811830.2 | 1988-05-19 | ||
| GB888811830A GB8811830D0 (en) | 1988-05-19 | 1988-05-19 | Oral compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1325777C true CA1325777C (en) | 1994-01-04 |
Family
ID=10637145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000600005A Expired - Fee Related CA1325777C (en) | 1988-05-19 | 1989-05-17 | Oral compositions |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US4933171A (en) |
| EP (1) | EP0346957A1 (en) |
| JP (1) | JPH0222216A (en) |
| AU (1) | AU615746B2 (en) |
| BR (1) | BR8902339A (en) |
| CA (1) | CA1325777C (en) |
| GB (1) | GB8811830D0 (en) |
| IN (1) | IN169444B (en) |
| PH (1) | PH25375A (en) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5098297A (en) * | 1988-10-04 | 1992-03-24 | John O. Butler Company | Apparatus for application of a tooth desensitizing composition |
| US5234688A (en) * | 1988-12-29 | 1993-08-10 | Colgate-Palmolive Company | Anti-plaque dentifrice packaged in resilient squeezable form maintaining dispensing container |
| US5260062A (en) * | 1988-12-29 | 1993-11-09 | Colgate-Palmolive Company | Anti-plaque and anti-tartar dentifrices in plastic pump dispensers |
| GB8901587D0 (en) * | 1989-01-25 | 1989-03-15 | Unilever Plc | Dentifrices |
| GB8906914D0 (en) * | 1989-03-28 | 1989-05-10 | Beecham Group Plc | Novel compositions |
| GB8927073D0 (en) * | 1989-11-30 | 1990-01-31 | Unilever Plc | Oral compositions |
| JP3157563B2 (en) * | 1991-10-29 | 2001-04-16 | 株式会社サンギ | Toothpaste |
| US5356615A (en) * | 1991-01-30 | 1994-10-18 | Colgate Palmolive Company | Antiplaque oral compositions |
| US5240697A (en) * | 1991-10-17 | 1993-08-31 | Colgate-Palmolive Company | Desensitizing anti-tartar dentifrice |
| US5374417A (en) * | 1991-10-17 | 1994-12-20 | Colgate Palmolive Company | Desensitizing dentifrice |
| GB2290027B (en) * | 1991-10-17 | 1996-04-17 | Colgate Palmolive Co | Desensitizing Anti-tartar Dentifrice |
| US5468489A (en) * | 1991-10-29 | 1995-11-21 | Sangi Co., Ltd. | Dentifrice containing antibacterial material |
| US5270031A (en) * | 1991-12-20 | 1993-12-14 | Block Drug Company Inc. | Dentinal desensitizing compositions |
| WO1993025184A1 (en) * | 1992-06-10 | 1993-12-23 | The Procter & Gamble Company | Dentifrice compositions |
| GB9212706D0 (en) * | 1992-06-16 | 1992-07-29 | Smithkline Beecham Plc | Novel composition |
| US5505933A (en) * | 1994-06-27 | 1996-04-09 | Colgate Palmolive Company | Desensitizing anti-tartar dentifrice |
| US5843409A (en) * | 1994-08-08 | 1998-12-01 | Colgate Palmolive Company | Two component dentifrice for the treatment of dentinal hypersensitivity |
| US5716625A (en) * | 1994-12-21 | 1998-02-10 | Cosmederm Technologies | Formulations and methods for reducing skin irritation |
| US7404967B2 (en) | 1994-12-21 | 2008-07-29 | Cosmederm, Inc. | Topical product formulations containing strontium for reducing skin irritation |
| JP4040705B2 (en) * | 1996-01-24 | 2008-01-30 | 株式会社サンギ | Oral composition |
| DE19730651A1 (en) * | 1997-07-17 | 1999-01-21 | Henkel Kgaa | Oral and dental care products for sensitive teeth |
| US6919070B1 (en) * | 1997-10-17 | 2005-07-19 | Zakrytoe Aktsionernoe Obschestvo “OSTIM” | Stomatic composition |
| NZ524610A (en) | 1999-03-12 | 2004-09-24 | Pfizer Prod Inc | Composition containing a soluble potassium salt, a sodium alkylsulphonate, a polar surfactant and a carrier, use as a toothpaste, oral rinse, skin detergent, shampoo, hard surface cleaner and a fabric detergent |
| US8652445B2 (en) * | 2004-07-02 | 2014-02-18 | Discus Dental, Llc | Dental compositions with sensitivity relief |
| WO2007060381A1 (en) * | 2005-11-24 | 2007-05-31 | Santosolve As | Strontium-containing compositions and their use in methods of cosmetic treatment |
| GB0706787D0 (en) * | 2007-04-05 | 2007-05-16 | Glaxo Group Ltd | Novel use |
| EP2281543A1 (en) * | 2009-07-27 | 2011-02-09 | The Procter & Gamble Company | Oral care compositions which comprise stannous and potassium salts |
| EP2281544A1 (en) * | 2009-07-27 | 2011-02-09 | The Procter & Gamble Company | Oral care compositions which comprise stannous, potassium and monoflurophosphate |
| US8658139B1 (en) | 2010-02-27 | 2014-02-25 | Squigle, Inc. | Prevention and treatment of oral diseases |
| US9433569B2 (en) | 2011-05-26 | 2016-09-06 | Coswell S.P.A. | Dental care products comprising carbonate-substituted fluoro-hydroxyapatite particles |
| US9468593B2 (en) * | 2012-09-05 | 2016-10-18 | Kabushiki Kaisha Sangi | Oral composition |
| GB201317105D0 (en) * | 2013-09-26 | 2013-11-06 | Glaxo Group Ltd | Novel Composition |
| EA037204B1 (en) * | 2016-04-18 | 2021-02-19 | Юнилевер Н.В. | Oral care composition |
| USD823469S1 (en) | 2016-04-18 | 2018-07-17 | Conopco Inc. | Tooth cleaning appliance |
| CN109475473A (en) * | 2016-07-14 | 2019-03-15 | 荷兰联合利华有限公司 | Oral care composition comprising the composite material granular containing cationic germicide |
| JP2021008416A (en) * | 2019-06-28 | 2021-01-28 | サンスター スイス エスエー | Composition for oral cavity |
| JP2021008417A (en) * | 2019-06-28 | 2021-01-28 | サンスター スイス エスエー | Composition for oral cavity |
| CN113226984A (en) | 2018-12-27 | 2021-08-06 | 盛势达（瑞士）有限公司 | Oral composition |
| JP2021008418A (en) * | 2019-06-28 | 2021-01-28 | サンスター スイス エスエー | Composition for oral cavity |
| JP2021008415A (en) * | 2019-06-28 | 2021-01-28 | サンスター スイス エスエー | Composition for oral cavity |
| JP2020105106A (en) * | 2018-12-27 | 2020-07-09 | サンスター スイス エスエー | Oral composition |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA680108A (en) * | 1964-02-18 | S. Gubner Richard | Dental therapeutic compositions and method | |
| US3699221A (en) * | 1965-02-23 | 1972-10-17 | Murray L Schole | Dental preparations |
| AT335618B (en) * | 1971-07-13 | 1977-03-25 | Scheller Durodont Dr | ORAL AND DENTAL CARE PRODUCTS |
| US3863066A (en) * | 1973-04-16 | 1975-01-28 | Coulter Electronics | Voltage run-down circuit |
| US4011309A (en) * | 1975-01-20 | 1977-03-08 | Marion Laboratories, Inc. | Dentifrice composition and method for desensitizing sensitive teeth |
| DE2602981A1 (en) * | 1976-01-27 | 1977-07-28 | Carter Wallace | Dental prophylactic compsn. - contg. polyphosphate(s) and polyvalent cation |
| GB1547874A (en) * | 1976-05-19 | 1979-06-27 | Unilever Ltd | Dentifrices |
| GB1586915A (en) * | 1978-03-10 | 1981-03-25 | British Charcoals & Macdonalds | Synthetic bone ash |
| JPS5673014A (en) * | 1979-11-15 | 1981-06-17 | Dentaru Kagaku Kk | Toothpaste composition |
| EP0029332A1 (en) * | 1979-11-15 | 1981-05-27 | Dental Chemical Co., Limited | Dentifrice compositions |
| US4342741A (en) * | 1981-04-27 | 1982-08-03 | Dental Chemical Co., Ltd. | Dentifrice compositions |
| JPS6048926A (en) * | 1983-08-22 | 1985-03-16 | ミルトン・ホドツシユ | Treatment for gingiva and dental root membrane tissue |
| JPS60156620A (en) * | 1983-12-22 | 1985-08-16 | ザ ユニヴアーシテイ オブ メルボルン | Dental caries controller |
| US4631185A (en) * | 1984-03-13 | 1986-12-23 | The Trustees Of Columbia University In The City Of New York | Method of desensitizing hypersensitive dentin employing compositions containing potassium salts |
| US4634589A (en) * | 1984-05-18 | 1987-01-06 | Wurttembergische Parfumerie-Fabrik Gmbh | Dentifrice for hypersensitive teeth |
| GB8527962D0 (en) * | 1985-11-13 | 1985-12-18 | Neirinckx R D | Desensitizing dental composition |
| CA1315480C (en) * | 1986-06-12 | 1993-03-30 | Eric Charles Reynolds | Phosphopeptides |
| CA1322960C (en) * | 1987-02-12 | 1993-10-12 | Domenico Caserio | Dentifrice composition for desensitising sensitive teeth |
| GB8706187D0 (en) * | 1987-03-16 | 1987-04-23 | Unilever Plc | Dentifrice compositions |
-
1988
- 1988-05-19 GB GB888811830A patent/GB8811830D0/en active Pending
-
1989
- 1989-05-12 EP EP89201204A patent/EP0346957A1/en not_active Withdrawn
- 1989-05-16 AU AU34810/89A patent/AU615746B2/en not_active Ceased
- 1989-05-17 CA CA000600005A patent/CA1325777C/en not_active Expired - Fee Related
- 1989-05-18 IN IN133/BOM/89A patent/IN169444B/en unknown
- 1989-05-18 PH PH38667A patent/PH25375A/en unknown
- 1989-05-19 US US07/354,658 patent/US4933171A/en not_active Expired - Lifetime
- 1989-05-19 JP JP1126524A patent/JPH0222216A/en active Pending
- 1989-05-19 BR BR898902339A patent/BR8902339A/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US4933171A (en) | 1990-06-12 |
| AU615746B2 (en) | 1991-10-10 |
| BR8902339A (en) | 1990-01-09 |
| PH25375A (en) | 1991-06-03 |
| AU3481089A (en) | 1989-11-23 |
| JPH0222216A (en) | 1990-01-25 |
| EP0346957A1 (en) | 1989-12-20 |
| IN169444B (en) | 1991-10-19 |
| GB8811830D0 (en) | 1988-06-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |