CA2001859A1 - Sustained release drug-resin complexes - Google Patents

Sustained release drug-resin complexes

Info

Publication number
CA2001859A1
CA2001859A1 CA2001859A CA2001859A CA2001859A1 CA 2001859 A1 CA2001859 A1 CA 2001859A1 CA 2001859 A CA2001859 A CA 2001859A CA 2001859 A CA2001859 A CA 2001859A CA 2001859 A1 CA2001859 A1 CA 2001859A1
Authority
CA
Canada
Prior art keywords
drug
sustained release
release drug
resin complexes
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2001859A
Other languages
French (fr)
Other versions
CA2001859C (en
Inventor
William Joseph Kelleher
Anthony Earl Carpanzano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
William Joseph Kelleher
Anthony Earl Carpanzano
Richardson-Vicks Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William Joseph Kelleher, Anthony Earl Carpanzano, Richardson-Vicks Inc. filed Critical William Joseph Kelleher
Publication of CA2001859A1 publication Critical patent/CA2001859A1/en
Application granted granted Critical
Publication of CA2001859C publication Critical patent/CA2001859C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin

Abstract

Disclosed are oral pharmaceutical preparations which comprise a pharmacologically active drug bound to small particles of an ion-exchange resin to provide a drug-resin complex having a drug content above a specified value. The drug-resin complex is subsequently coated with a water-permeable diffusion barrier coating that is insoluble in gastrointestinal fluids thereby providing a controllable sustained release of drug under conditions encountered in the gastrointestinal tract.
CA002001859A 1988-11-02 1989-10-31 Sustained release drug-resin complexes Expired - Lifetime CA2001859C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/265,910 US4996047A (en) 1988-11-02 1988-11-02 Sustained release drug-resin complexes
USS.N.265,910 1988-11-02

Publications (2)

Publication Number Publication Date
CA2001859A1 true CA2001859A1 (en) 1990-04-02
CA2001859C CA2001859C (en) 1995-10-31

Family

ID=23012384

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002001859A Expired - Lifetime CA2001859C (en) 1988-11-02 1989-10-31 Sustained release drug-resin complexes

Country Status (11)

Country Link
US (1) US4996047A (en)
EP (1) EP0367746B1 (en)
JP (1) JP2941314B2 (en)
AT (1) ATE101033T1 (en)
AU (1) AU638420B2 (en)
CA (1) CA2001859C (en)
DE (1) DE68912882T2 (en)
DK (1) DK175659B1 (en)
IE (1) IE62765B1 (en)
NZ (1) NZ231229A (en)
PH (1) PH26699A (en)

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Also Published As

Publication number Publication date
AU4430689A (en) 1990-05-10
EP0367746A2 (en) 1990-05-09
AU638420B2 (en) 1993-07-01
EP0367746A3 (en) 1991-01-23
DK175659B1 (en) 2005-01-10
IE62765B1 (en) 1995-02-22
US4996047A (en) 1991-02-26
DK546389A (en) 1990-05-03
CA2001859C (en) 1995-10-31
JPH02172912A (en) 1990-07-04
ATE101033T1 (en) 1994-02-15
PH26699A (en) 1992-09-14
DK546389D0 (en) 1989-11-02
NZ231229A (en) 1992-03-26
JP2941314B2 (en) 1999-08-25
DE68912882T2 (en) 1994-06-01
DE68912882D1 (en) 1994-03-17
EP0367746B1 (en) 1994-02-02
IE893537L (en) 1990-05-02

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