CA2001969C

CA2001969C - Polysiloxane-polyurethanes and contact lenses thereof

Info

Publication number: CA2001969C
Application number: CA002001969A
Authority: CA
Inventors: Paul Harisiades
Original assignee: Ciba Spezialitaetenchemie Holding AG
Current assignee: Huntsman Advanced Materials Switzerland GmbH
Priority date: 1988-11-03
Filing date: 1989-11-01
Publication date: 2000-05-30
Anticipated expiration: 2009-11-01
Also published as: PT92162B; AU4385289A; IE893531L; EP0367720A2; ES2057173T3; TW205557B; EP0367720A3; JP2845998B2; PT92162A; DE68916907T2; ATE108809T1; DK547189A; DK547189D0; DE68916907D1; HK9297A; EP0367720B1; IE63682B1; US4962178A; AU629252B2; CA2001969A1

Abstract

A novel polysiloxane polyurethane is described which is obtained by reaction of an isocyanate capped polysiloxane prepolymer with a polysiloxane-disilanol and which contains O-silyl-urethane linkages. The novel polysiloxane-poly-urethanes are useful as oxygen permeable membranes or films, as bandages and drug carriers, for example in transdermal drug delivery, and especially as highly oxygen permeable, soft contact lenses.

Description

,n 2~Q1969 6V-17294/+/CGC 1380 Novel Pol siloxane- of urethanes and Contact Lenses Thereof Silicones occupy an important place in the chemical industry in~a variety of applications ranging from lubricants to sealants. Silicone fluids composed of polydimethylsiloxane combine many useful properties such as excellent thermal stability, chemical inertness, small changes in viscosity with changes in temperature, high oxygen permeability, outstanding shear stability, and excellent lubricity. They have found extensive use as adhesives, sealants, coatings, softeners, lubricants, dispersants, and antifoam agents in non-aqueous systems in industries as diverse as construction, pharmaceuticals, rubber, plastics, textiles, cosmetics, printing and founding.
More recently silicone rubber materials have been used in biomedical products such as artificial organs and contact lenses. The great benefit of silicone to the latter stems from its high permeability to oxygen although this advantage is offset by its intrinsic hydrophobicity. For this reason all present commercial contact lens formulations which incorporate silicone are hard lens formulations which contain it only in limited amounts. It would be highly desirable to produce a contact lens composed entirely of silicone rubber since it offers the highest oxygen permeability of all presently available materials. The enhancement of eye comfort and wearing time would represent a significant improvement in contact lens technology. However, this goalcannot be achieved until the hydrophobic surface of the silicone is rendered hydrophilic by some kind of surface modification, since silicone rubber alone adheres very strongly to the cornea and also rapidly attracts particulate matter.

Silicone rubber is made by crosslinking liquid polysiloxanes.
These rubbers are thermoset polymers which can be made to varying degrees of hardness and elasticity by controlling the degree of crosslinking and the molecular weight of the silicone fluid. Silicone rubber is usually made by vul-canizing polydimethylsiloxane fluids with organic peroxidesat elevated temperatures. Another approach to crosslinking employs hydrosilation in which poly(vinylalkylsiloxanes) are cured with poly(hydridoalkylsiloxanes) in the presence of transition metal catalysts. Silicone rubber has also been formed by chemically reacting, a,W-difunctionalpoly(di-organosiloxanes) with polyfunctional silanes andsiloxanes.
Typically the crosslinking reaction is a condensation which forms a siloxane bond and a volatile by product. Common examples of this type of cure reaction are silanol-alkoxy-silane (French Pat. 1,042,019), silanol-acetoxysilane (L. F.Ceyzeriat and P.Dumonth, German Appl. 1,121,803), silanol-silane (Midland Silicones, Brit.Pat. 804,199), and silanol-silanol (via the corresponding acetone oxime) (E.
Sweet, Dow Corning, Belg.Pat. 614,394.Suitable catalysts for these reactions are amines and carboxylic acid salts of Sn, Pb, Zn, Sb, Fe, Cd, Ba, Ca and Mn .
Organosiloxane isocyanates have been prepared (U. S. Patent 3,179,622) which vulcanize when exposed to moisture. In these cases the isocyanate group is joined to the siloxane through an alkyl group, rendering it unhydrolyzable.
Relatively few reports exist for the curing of silicones via the reaction of a silanol with an isocyanate yielding an 0-silylurethane linkage. This is probably due to the well known hydrolytic instability of this bond. To our knowledge there are no existing reports of a silicone rubber cross-linked by 0-silylurethane bonds that is resistant to hydrolytic decomposition.

The use of silanol terminated polydimethylsiloxanes has been reported in the modification of polysiloxanes with poly-urethanes (Moretto, U.S. Pat. No. 4,202,807) to improve the mechanical properties of the former at elevated temperatures.
No mention was made of the hydrolytic stability of the O-silylurethane bond in these materials. The only other mention of this bond in a polymeric material was made by Kaufman, Muller, and Wegchaupt (U. S. Patent No. 4,292,423in the preparation of organopolysiloxanes for coating purposes.
However, when the claimed organopolysiloxane was prepared entirely through the reaction of siloxanol groups withiso-cyanate groups (Example 1 of this patent), the coating was decomposed by atmospheric moisture and addition of 75 ~ by weight of the polyurethane, Desmodur L, wasnecessary to produce a hydrolytically stable coating.
High hydrolytic susceptibility is a property characteristic of O-silylurethanes since they were first reported by Andrianov, Losev, and Astakhin (Proc. Akad. Sci., USSR, Sect.
Chem 113, 247, [1957]) from the reaction of triethylsilanol and m-toluene-diisocyanate. These authors subsequently described their alcoholysis and hydrolysis (J. General Chem., USSR, 29, 2655, [1959]). This behaviour of 0-silylurethanes has been summarized by Noll in "Chemistry and Technology of Silicones", Academic Press, 1968, pp 99-100.
It has now unexpectedly been discovered, that by reaction of essential equivalent amounts of diisocyanate-capped poly-dialkylsiloxane-polyalkanols and poly-dimethylsiloxane-disilanols, a clear, flexible and elastic siloxane poly-urethane rubber is obtained which is completely resistant to hydrolysis under physiological conditions, despite the fact that half of all urethane groups in the polymer contain the -Si-O-C- bond. This novel polysiloxane-polyurethane is uniquely suited as a biocompatible, oxygen-permeable membrane ,~,, 2oossss or film and especially, as a crosslinked rubber, as a soft contact lens.
It has further been discovered that this polyurethane is uniquely suited to be grafted to polyvinyl alcohol or hydroxy-alkyl cellulose and thereby allows production of a composite.
material not only with excellent optical clarity and the characteristically high permeability to oxygen, but also with high wettability as well.
The instant invention therefore pertains to said novel polysiloxane-polyurethane, to ophthalmic devices thereof, such as contact lenses, to a process for manufacture of said polysiloxane-polyurethane polymers and to the use thereof for making e.g. ophthalmic devices, such as contact lenses. The polymers can be used as oxygen permeable membranes or films, as bandages and drug carriers, for example in transderma.l drug delivery, and especially as highly oxygen permeable, soft contact lenses.
The instant invention pertains to a polymer, suitable for use as an oxygen permeable membrane or an ophthalmic device, having based on total urethane groups 50 to 75 ~k of alkyl-urethane -C-NH-C00-C- groups and 50 to 25 ~ of silyl-urethane -C-NH-COO-Si- groups, which comprises the polymerization product of (a) 80-95 ~ by weight (based on the total polymer) of a poly-isocyanate capped, linear or branched polysiloxane pre-polymer (A), having.a molecular weight of about 1000 to about 10,000 and containing at least one isocyanate group per 3000 molecular weight unit of polysiloxane, said isocyanate groupsbeing attached to the polysiloxane through urethane linkages, said polysiloxane prepolymer having the structure A1, A2 or A3 (which are described in detail below); and :2001969 (b) 20-5 ~ by weight (based on the total polymer) of a linear polydialkyl- or polydiphenyl-siloxane disilanol (B) Ra I
HO Si H (B) I
Rb n where n is 2-50, and Ra and Rb are alkyl of 1 to 4 carbon atoms or phenyl. The molecular weight of these terminal silanol groups containing compounds is from about 24Oto about 10000, preferably from about 240 to about 1000.
The linear or branched polysiloxane prepolymer A is of one of the following general structures, A1, A2, or A3:

X-R1 Si0 Si0 Si0 Si-R1-X1 (Al) R2 X1 R1 R2 x2 R2 x ~2)3Si0 Si0 Si0 Si0 Si(R2y3 (A2) R2 X1 i 1 R2 X2 x y2 X-CH2CHCH20(CH2)g Si0 Si- (CHZY3~H2CHCH2 X3 (A3 ) R2 m R2 wherein R1 is a linear or branched alkylene group with 2-6 carbon atoms or a polyoxyalkylene group of structures 20019x9 -[CH2 ~ HO]pCH2 ~ H- o r -(CHZ)30CH2 ~ HCH2_ wherein R3 is hydrogen or methyl and p is an integer from -1-50; each R2 is independently methyl or phenyl; m is 2 to 50; x1 and x2 are integers from 1 to 500 with the proviso that the sum of xl + x2 is 12 to 1,000; y1 is 0 to 4 and y2 is 2to with the proviso that the respective ratios of xl+x2y1 ( for Al) and x1+x2y2 (for A2) are not greater than 70, yl + 2 y2 H
X 1 s -~-N-R4-NCO ~
O
H H
X1 is X or -~N-R4-NCO-Tl and O O
H H
X 3 i s X o r -~N-R4-N-CO-Tg O O
wherein T1 is A1 from which X1 has been abstracted, T3 is A3 from which X3 has been abstracted, and Rq is a diradical obtained by removing the NCO groups from an aliphatic, cycloaliphatic or aromatic di-isocyanate.
A preferred embodiment of the instant invention is a polymer where component A is a polysiloxane of structure A1 or A2, R1 is alkylene of 3 or 4 carbon atoms, each of R2 is methyl, xl+ x2 is 10 to 100, yl is 0 to 2, y2 is 2 to 3 and R4 is a 2p01.969 diradical of an aliphatic or cycloaliphatic diisocyanate with 6 to 10 carbon atoms.
A most preferred embodiment of the instant invention is a polymer where component A is polysiloxane of structure A1.
A further preferred embodiment is a polymer having based on total urethane groups 50 ~ of alkyl-urethane -C-NH-COO-C-groups and 50 ~ of silyl-urethane -C-NH-C00-Si- groups, which comprises the polymerization product of (a) 80-95 ~ by weight (based on the total polymer) of a poly-isocyanate capped, linear or branched polysiloxane pre-polymer A, having a molecular weight of about 1000 to about 10,000 and containing at least one isocyanate group per 3000 molecular weight unit of polysiloxane, said isocyanate groups being attached to the polysiloxane through urethane linkages, said polysiloxane prepolymer having the structure A1, A2 or A3, as disclosed hereinbefore, wherein Rl is alinear or branched alkylene group with 2-6carbon atoms or a polyoxy-alkylene group of structure -[CH21 HO]pCH21 H_ wherein R3 is hydrogen or methyl and p is an integer from 1-5; each R2 is methyl; m is 30 to 50; xl and x2 are integers from 10 to 50 with the proviso that the sum of xl + x2 is l2to 100: yl is 0 to 4 and y2is 2to 5 with the proviso that the respective ratios of "~ +"2y1 ( for A1 ) and xl +X2y2 ( for A2 ) are not greater than 40, yl+2 y2 -$_ H
each X, X1 and X3 iS OII N R4 NCO -~
O
and Rq is a diradical obtained by removing the NCO groupsfrom a cycloaliphatic di-isocyanate having up to 10 carbon atoms .
and (b) 20-5 $ by weight (based on the total polymer). of a linear polydialkyl- or polydiphenyl-siloxane disilanol (B) Ra I
HO Si H (B) I
Rb n where n is 2-10, and Ra and Rb are alkyl of l to 4 carbon atoms or phenyl.
Poly-functional polysiloxanes, useful as starting materials for the prepolymer (A), are of structures S1, S2 or S3:
I2 (2 ~2 I2 Hp-Rl Si0 Si0 Si0 Si-R1-OH
I I I I (sl) R2 xl I1 R2 x2 R2 (R2)3Si0 Si0 Si0 Si0 Si(R2y3 I I I (s2) R2 xl i 1 R2 x2 OH y2 ~oosss9 ~2 ~2 HO-CH2CHCH20(CH2)3 Si0 Si- (CH2)3~H2CHCH2 OH
(OH R R OH
2 m 2 wherein Rl, R2, xl, x2, Y1, Y2 and m are as described for formula A1, A2 and A3.
Diisocyanates useful to form the prepolymer.intermediate are aliphatic, cycloaliphatic or aromatic isocyanates. Said aliphatic diisocyanates are e.g. alkyl diisocyanates having up to 12 alkyl carbon atoms, preferably having 2 to 9alkyl carbon atoms, wherein alkyl is e.g. ethyl, propyl, hexyl or trimethylhexyl.
Said cycloaliphatic diisocyanates are e:g. cycloalkyl diisocyanates having up to three C5 or C6 cycloalkyl or .
cycloalkenyl groups which are unsubstituted or substituted by lower alkyl and/or carboxy, including cycloalkyl lower alkyl, unsubstutited or substituted by e.g. lower alkyl, diiso-cyanates. In case that more than one cycloalkyl group is present, these are connected to each other by a bond, lower alkylene, or a urethane group.
Said aromatic diisocyanates are e.g. diisocyanates having a naphthalene or up to three phenyl groups, which are unsub-stituted or substituted by lower alkyl, halogen, or lower alkoxy, e.g. methyl, chloro, or methoxy. In case that more than one phenyl group is present these are connected to each other by a bond, lower alkylene, or lower alkylidene or oxygen. "Lower" refers to groups having up to 7 carbon atoms.
Said diisocyanates are selected preferably from the group consisting of ethylene diisocyanate, 1,2-diisocyanatopropane, 1,3-diisocyanatopropane, 1,6-diisocyanatohexane, 1,6-diiso-cyanato-2,2,4-(2,4,4)-trimethylhexane, 2,2'-diisocyanato-2flfl19f 9 diethyl fumarate, 1,2- 1,3-, 1,5-, 1,6-, 1,7-, 1,8-, 2,7- and 2,3-diisocyanatonaphthalene: 2,4- and2,7-diisocyanato-1-methyl-naphthalene 4,4'-diisocyanatobiphenyl; 1,2-diiso--cyanatocyclohexane, 1,3-diisocyanatocyclohexane, 1,4-diiso-cyanatobenzene, bis-(4-isocyanatocyclohexanyl)methane, bis(4-isocyanato-phenyl)methane, 1,2- and 1,4-toluene diiso-cyanate, 3,3-dichloro-4,4'-diisocyanatobiphenyl, hydrogenated toluene diisocyanate, 1-isocyanatomethyl-5-isocyanato-1,3,3-trimethylcyclohexane (isophorone diisocyanate).
The diisocyanates can be used alone or in combination with each other. They have preferably 6 to 10 carbon atoms except from the two NCO-groups.
Preferred are aliphatic diisocyanates, withisophorone-diiso-cyanate andl,6-diisocyanato-2,2,4-(-2,4,4)trimethylhexane being most preferred.
The linear polydialkyl- or polyphenyl-siloxane disilanol is of structure tB) disclosed hereinbefore where n is 2-50, and Ra and Rb are alkyl of 1 to 4 carbon atoms, or phenyl preferably methyl.
Preferred are polydialkylsiloxane-disilanols wherein n is 3-6 and Ra and Rb are methyl.
Preferably the polymers of the instant invention are useful as ophthalmic devices such as contact lenses or intraocular lenses. Most preferably the polymers are useful as contact lenses.
The isocyanato functional polysiloxane prepolymers A1-A3 are obtained conveniently from the corresponding poly-hydroxy-alkylene functional polysiloxanes S1-S3 by the known techniques of polyurethane prepolymer synthesis.Polysiloxane di-, tri- and tetraalkanols can be used alone or as mixtures, r 2oossss as long as the functionality of the mixture isgreater than2.
As a first step, the polysiloxane is reacted, either in bulk - or in solution, with a given amount of diisocyanate, prefer-ably in the presence of a catalyst. This catalyst may be a tertiary amino group containing compound such astriethyl- _ amine, pyridine or diaminobicyclooctane, or a metalbased catalyst like dibutyltin dilaurate or stannous octoate.The reaction is carried out at either ambient or elevated tem-peratures under a dry nitrogen blanket and can be followed conveniently by NCO-titration or IR analysis. The molar ratio of OH to NCO groups can be 1:1.5 to 1:3 and is preferably in the range of 1:2.05-1:2.1.
Although it is preferable to react one equivalent reactive polysiloxane with close to two equivalents diisocyanate and thereby obtain an isocyanate-endcapped polysiloxane, due to the laws of polycondensation kinetics a certain amount o.f chain extended product, in which the endcapped polymer contains two polysiloxane chains connected by a diisocyanate unit, is always obtained and can be analyzed, for instance by gel permeation chromatography.
It is therefore within the scope of the present invention to use as polysiloxanes prepolymer obtained from polysiloxanes of structures A1 and A3 by chain-extension reactions commonly used by those skilled in the art of polycondensation, especially polyurethane chemistry. Such chain extension can be achieved by instance by polycondensation of the afore-mentioned polysiloxane diols, with diacid chlorides or anhydrides or dianhydrides, such as terephthaloyl chloride, adipic acid dichloride, malefic anhydride, phthalic anhydride or benzophenone-tetracarboxylic acid and dianhydride~ but preferably with diisocyanates of the structures mentioned above, in which case the synthesis step for preparing the NCO-capped prepolymer as described is simply carried out with less than a 2:1 excess of NCO over -OH-groups likewise, the 2~~~gG9 NCO-terminated prepolymers obtained can be chain extended with diols or diamines according to the known techniques of poly-urethane technology, with, for example, ethylene glycol, propylene glycol, butanediol, hexanediol or polyetherdiols containing ethyleneoxide, propyleneoxide or n-butylene oxide repeating units or fluorinated polyether groups; polyester diols;
ethylenediamine, hexanediamine and diprimary or di-secondary amines in general, including diamines derived from polyalkylene oxides. To the extent that through these chain extension additional amide, urethane or urea groups are introduced into the structure, they contribute by hydrogen-bonding to the rigidity and clarity of the polymer. Chain extensions of the sort just described, however, dilute the overall polysiloxane extent of the polymer and therefore lower the oxygen permeability in the final polymer.
For producing contact lenses, the thoroughly mixed components - isocyanate capped polysiloxane prepolymer, polysiloxane-di-silanol and catalyst - are preferably filled into one part of a contact lens mold, the mold is closed and the assembly is kept at the reaction temperature (50-80°C) for the required length of time, after which the mold is opened up and the lens is taken out.
Since polysiloxane-rubbers, including the one described in this invention, are very hydrophobic and therefore by them-selves unsuited as contact lens materials, the surfaces of the prepared lenses need to be made hydrophilic. This can be achieved by surface treatments or preferably by transfer grafting ,A

polyvinyl alcohol (PVA), ethoxylated polyvinyl alcohol (EPVA) or hydroxy-ethyl cellulose (HEC) as described in European Patent No.
362,137. For transfer-grafting, the contact lens molds are coated with a thin (0.5-100 or preferably 0.5-10 micron) film of PVA or HEC prior to casting the lens. During polymerization, the PVA or HEC film is transferred from the mold to the forming polymer by covalent bonding via urethane linkages. After the lens is removed, en extremely wettable surface is obtained, which is not dissolved away in hot water or in a solvent and resists abrasion. It has been discovered that the polysiloxane-polyurethanes of this invention are uniquely suited for carrying out the transfer-grafting process described in European Patent No. 362,137 by using polyvinyl alcohol as surface coating. Thus, contact lenses prepared according to this invention in a mold coated with PVA or hydroxyalkyl cellulose are a preferred embodiment of this invention.
The following examples are presented for the purpose of illustration only and are not to be construed to limit the nature and scope of the invention in any manner whatsoever.
In the following examples, specific oxygen permeability (o2~DK) is determined by measuring dissolved oxygen permeability at 25°C with a polarographic electrode in an air-saturated aqueous environment and is expressed in units 02 ~DK - cm3 ( STP ) x~ cm X1010 ( barrers ) cm2x sec x cmAg p,."...

13a 2 O O 1 9 6 9 Wettability is determined by measuring the contact angle of an n-octane droplet which has risen to the lower surface of a 1 mm thick sample sheet immersed in octane saturated distilled water at 36°C.
Tensile strength, Young's modulus and elongation are measured on 1 mm thick sheets using an INSTRON model 1123 testing apparatus.
Hardness is determined using a Shore-A durometer on center cut buttons of 10 mm diameter and 8 mm height.

2001.969 - _ Example 1 a) Svnthesis of Tri-isocyanate Macromer: Polydimethylsiloxane trialkanol of structure S2 wherein R1 is 1,3-butylene (MW 6690) (159.86 g, 0:0277 mole) are mechanically stirred with two equivalents of isophorone diisocyanate (IPDI), (18.56g, 0.0832 mole) under a nitrogen atmosphere. After ten minutes, dibutyltin dilaurate (DBTL) (32 mg, 0.02 ~) catalyst is added. The reaction mixture becomes homogeneous 90-120mi-nutes after addition of the catalyst and the NCO concen-tration reaches the theoretical level after six hoursand does not change with further stirring. The triisocyanate macromer is stored at 5°C under nitrogen in plastic containers. It has an intrinsic viscosity [~] of 0.13 and a MW, based on ~ NCO, of 7400. Its dispersity, by GPC, is 5.9.
b) Preparation of oligomeric siloxane diols from a,w-siloxane dichloride: The siloxane diols are prepared by hydrolysis of the corresponding siloxane dichlorides in a cooled mixture of pH 7 buffered water and diethyl ether.After extraction, the polysiloxane diols are purified by distillation. The following disilanols of formula B, wherein Ra and Rb are methyl, are prepared:
_n _MW YIELD

3 240 87 72-74C/0.3 mm 4 314 85 86-88C/0.4 mm 6 463 86 113C/1.2 mm 8 611 82 135C/0.4 mm These oligomers are stable with respect to self-condensation when stored in plastic containers under nitrogen.
c) Preparation of 0- --Silylurethane Crosslinked Silicone Rubber: The polydimethylsiloxane tri-isocyanate macromer (MW7400) (24.25 g, 3.286 mmole) is stirred in vacuo (15 torr) 2oo19s9 with hexamethyltrisiloxane -diol (1.14 g, 4.765 mmole) for 30 minutes. The formulation is stable for over 30 days when stored under nitrogen at 5°C; at room temperature the formulation is stable for one week. Five square inch sheet molds are filled with the siloxane formulations in thickness of 1.O mm, 0.5 mm, 0.3 mm and 0.1 mm. The molds are made against MYLAR, which has previously been coated with a thin layer (1.0 ~) of PVA (Mn 41,000, Mw 114,000) which becomes grafted to the silicone during cure, leaving it with a clear, wettable surface. Polypropylene button molds (diam. =15 mm, height = 10 mm) are also filled. Curing is done at 60 °C under a nitrogen atmosphere for 24 hours. A clear, resilient rubber is obtained which is completely resistant to hydrolysis in distilled water at 80°C for one month. Hardness measurements, as well as degree of swelling and percent extractibles after two weeks in absolute ethanol are made on buttons weighing approximately 2.3 g.
Example 2: The polydimethylsiloxane tri-isocyanate macromer of example 1 (MW 7400) (22.47 g, 3.047 mmoles) is mixed with octamethyltetrasiloxane diol (1.38 g, 4.419 mmole) on a rotaevaporator in vacuo (15 torr) for 30 minutes. Polymers are cast in form of sheets and buttons, as described in example lc), with curing carried out at 60°C in a nitrogen atmosphere for 24 hours. The properties of the 0-silyl-urethane linked polysiloxane of this example are as follows:

Property Initial After 4 weeks at 80°C
in distilled water Tensile strength [kg/cm2] 7.27 7.32-Young's modulus [kg/cm2] 10.67 10.73 Elongation to break (~) 150 180 Shore A hardness 34 -Contact Angles Advancing 32 35 Receding 27 24 Ethanol swelling (~) 39.2 -Extractibles (~) 1.2 -02DK (barrers) 376 Example 3 a) Synthesis of Tri-isocyanate Macromer: Polydimethylsiloxane trialkanol of Structure S1 wherein R1 is 3,.6-dioxaocta-methylene (MW 6280), (270.14 g, 43.00 mmole) is mechanically stirred with three equivalents of isophorone diisocyanate (IPDI) (29.65 g, 133.90 mmole) under a nitrogen atmosphere.
The temperature is raised to 50°C for 3 hours after which time the NCO level drops to the theoretical level. The triisocyanate macromer is stored at 5°C under nitrogen in plastic containers. It has a molecular weight, based on NCO, of 6980, and a polydispersity, by GPC of 20.6.
b) Pre aration of Sil 1-Urethane Crosslinked Silicone Rubber:
The polydimethyl siloxane tri-isocyanate macromer (MW 6980) (20.91 g,. 3.00 mmole) is stirred in vacuo (15 torr) with hexamethyltrisiloxane diol (1.08 g, 4.50 mmole) for 30mi-nutes. The formulation is stable for over 30 days when stored under nitrogen at 5°C; at room temperature the formulation is stable for 48 hours. Five inch square sheet molds are filled with the siloxane formulations in thickness of 1.00 mm, 2pp1~69 0.5 mm, 0.3 mm and ~.1 mm. The molds are made against MYLAR, which has previously been coated with polyvinyl alcohol, as described in example 1. Polypropylene button molds (diam: -15 mm, height = 10 mm) are also filled and curing is done at 60°C unter a nitrogen atmosphere for 24 hours. A clear, resilient rubber is obtained which is completely resistant to hydrolysis in distilled water at 80°C for one month.
Example 4: Example Usina Structure A3 (Mercor Tetraol) a) Synthesis of Tetra-isocyanate Macromer:Polydimethyl-siloxane tetra-alkanol of structure S3 (MW 3400) (167.18 g, 49.17 mmole) is mechanically stirred with two equivalents of isophorone diisocyanate (IPDI) (43.72 g, 196.7 mmole) for ten minutes under a nitrogen atmosphere. Then dibutyltin-dilaurate (33 mg, 0.02 ~) catalyst is added. The theoretical endpoint is reached after 21 hours of stirring. The tetra-~isocyanate macromer is stored at 5°C under nitrogen in plastic containers and has a Mw of 4265 (by NCO titration).
b) Pre aration of a Sil 1 Urethane Crosslinked Silicone Rubber: The polydimethylsiloxane tetra-isocyanate macromer (MW 4265) (16.79 g, 3.94 mmole) is stirred on a roto-evaporator in vacuo (25 torr) with octamethyltetrasiloxane diol (2.47 g, 7.88 mmole) for 30 minutes. The mixture is filled into molds and cured at 60°C under a nitrogen atmosphere for 24 hours as described in example 1. A clear, resilient rubber is obtained which is completely resistant to hydrolysis in distilled water for 80°C for one month.
Example 5: Preparation of a Contact Lens The silicone composition described in example 1c is prepared.
Zero expansion polypropylene) lens molds are dip coated with a 2 ~ solution of EPVA in water-isopropanol (4:1) containing 0.1 ~ LODYNE S-100 surfactant (CIBA-GEIGY). After drying in a 60°C oven for one hour, each mold is filled with four drops of the silicone composition and subsequently clamped shut.

. 2oo~.9s9 Curing is carried out as previously described at 60°C for 24 hours. Lenses are removed by opening the molds and dropping them in boiling water. Clear, resilient, highly wettable lenses are obtained.

Claims

1. A siloxane urethane polymer, suitable for use as an oxygen permeable membrane or an ophthalmic device, having based on total urethane groups 50 to 75 % of alkyl-urethane -C-NH-COO-C- groups and 50 to 25 % of silyl-urethane -C-NH-COO-Si- groups, which comprises the polymerization product of (a) 80-95 % by weight (based on the total polymer) of a polyisocyanate capped, linear or branched polysiloxane prepolymer A, having a molecular weight of about 1000 to about 10,000 and containing at least one isocyanate group per 3000 molecular weight unit of polysiloxane, said isocyanate groups being attached to the polysiloxane through urethane linkages, said polysiloxane prepolymer having the structure A1, A2 or A3:
wherein R1 is a linear or branched alkylene group with 2-6 carbon atoms or a polyoxyalkylene group of structures wherein R3 is hydrogen or methyl and p is an integer from 1-50; each R2 is independently methyl or phenyl; m is 2 to 50; x1 and x2 are integers from 1 to 500 with the proviso that the sum of x1 + x2 is 12 to 1,000; yl is 0 to 4 arid y2 is 2 to with the proviso that the respective ratios of (for A1) and (for A2) are not greater than 70, wherein T1 is A1 from which X1 has been abstracted, T3 is A3 from which X3 has been abstracted, and R4 is a diradical obtained by removing the NCO groups from an aliphatic, cycloaliphatic or aromatic di-isocyanate: and (b) 20-5 % by weight (based on the total polymer) of a linear polydialkyl- or polydiphenyl-siloxane disilanol (B) where n is 2-50, and R a and R b are alkyl of 1 to 4 carbon atoms or phenyl.

2. A siloxane urethane polymer, according to claim 1, having based on total urethane groups 50 % of alkyl-urethane -C-NH-COO-C- groups and 50 % of silyl-urethane -C-NH-COO-Si-groups, which comprises the polymerization product of (a) 80-95 % by weight (based on the total polymer) of a polyisocyanate capped, linear or branched polysiloxane prepolymer A, having a molecular weight of about 1000 to about 10,000 and containing at least one isocyanate group per 3000 molecular weight unit of polysiloxane, said isocyanate groups being attached to the polysiloxane through urethane linkages, said polysiloxane prepolymer having the structure A1, A2 or A3, as disclosed in claim 1, wherein R1 is a linear or branched alkylene group with 2-6carbon atoms or a polyoxyalkylene group of structure wherein R3 is hydrogen or methyl and p is an integer from 1-5; each R2 is methyl; m is 30 to 50: x1 and x2 are integers from 10 to 50 with the proviso that the sum of x1 + x2 is 12 to 100; y1 is 0 to 4 and y2 is 2 to 5 with the proviso that the respective ratios of (for A1) and (for A2) are not greater than 40, each X, X1 and X3 is and R4 is a diradical obtained by removing the NCO groups from a cycloaliphatic di-isocyanate having up to 10 carbon atoms:
and (b) 20-5 % by weight (based on the total polymer) of a linear polydialkyl- or polydiphenyl-siloxane disilanol (B) where n is 2-10, and R a and R b are alkyl of 1 to 4 carbon atoms or phenyl.

3. A polymer according to claim 1 wherein the prepolymer of component (a) has structure A1 or A2.

4. A polymer according to claim 3 wherein the prepolymer of component (a) has structure A1.

5. A polymer according to claim 1 wherein the prepolymer of component (a) has structure A1 or A2, R1 is alkylene of 3 or 4 carbon atoms, each of R2 is methyl, x1 + x2 is 10 to 100, y1 is 0 to 2, y2 is 2 to 3, and R4 is a diradical of an aliphatic or cycloaliphatic diisocyanate with 6 to 10 carbon atoms.

6. A polymer according to claim 1 wherein the prepolymer of component (a) has structure A1, A2 or A3 and is capped with a diisocyanate or mixture of isocyanates selected from the group consisting of ethylene diisocyanate, 1,2-diisocyanato-propane, 1,3-diisocyanatopropane, 1,6-diisocyanatohexane, 1,6-diisocyanato-2,2,4-(2,9,4)-trimethylhexane, 2,2'-diiso-cyanatodiethylfumarate, 1,2- 1,3-, 1,5-, 1,6-, 1,7-, 1,8-, 2,7- and 2,3-diisocyanatonaphthalene; 2,4- and 2,7-diiso-cyanato-1-methyl-naphthalene; 4,4'-diisocyanatobiphenyl:
1,2-diisocyanatocyclohexane, 1,3-diisocyanatocyclohexane, 1,4-diisocyanatobenzene, bis-(4-isocyanatocyclohexanyl)-methane, bis(4-isocyanato-phenyl)methane, 1,2-and 1,4-toluene diisocyanate, 3,3-dichloro-4,4'-diisocyanatobiphenyl, hydrogenated toluene diisocyanate, 1-isocyanatomethyl-5-iso-cyanato-1,3,3-trimethylcyclohexane (isophorone diisocyanate).

7. A polymer according to claim 6 wherein the isocyanate is isophorone diisocyanate or 1,6-diisocyanato-2,2,4-(2,4,4-)-trimethylhexane.

8. A polymer according to claim 1 where in the siloxane disilanol of component (b) R a and R b are methyl.

9. A polymer according to claim 8 where in the siloxane disilanol of component (b) n is 3-6.

10. A polymer according to claim 1 which is in the form of an ophthalmic device.

11. A polymer according to claim 10 which is in the form of a contact lens.

12. An ophthalmic device consisting essentially of a polymer as defined in claim 1.

13. An ophthalmic device comprising a preformed, thin, hydrophilic polymeric surface of a hydrophilic polymer being intimately bonded, through a multiplicity of covalent bonds distributed essentially uniformly across the entire polymeric surface/polymer substrate interface, to a polymer substrate of a polymer as defined in claim 1.

14. An ophthalmic device according to claim 13 wherein the hydrophilic polymer is polyvinyl alcohol, ethoxylated polyvinylalcohol or hydroxyethylcellulose.

15. An ophthalmic device according to claim 12 which is a contact lens.

16. An ophthalmic device according to claim 13 which is a contact lens.

17. An ophthalmic device according to claim l4 which is a contact lens.

18. A process for the manufacture of a polymer as defined in claim 1 by conventionally reacting components (A) and (B) which are as defined in claim 1.

19. A process for the manufacture of a contact lens as defined in claim 16, having a preformed, optically true, thin, conforming, continuous, integral, wettable hydrophilic polymeric surface on an essentially hydrophobic polymer form, said surface being intimately bonded and copolymerized through a multiplicity of covalent bonds distributed essentially uniformly across the entire polymeric surface/polymer substrate interface, which process comprises (a) coating a mold with a film-forming first hydrophilic polymer, said polymer containing sites capable of undergoing subsequent copolymerization with a prepolymer/disilanol mixture required to form a hydrophobic polymer as defined in claim 1, (b) polymerizing the prepolymer/disilanol mixture required to form the hydrophobic polymer as. defined in claim 1 in contact with the coated mold whereby effecting copolymerization with the reactive sites present in the mold coating to achieve intimate bonding therewith by way of a multiplicity of covalent bonds, and (c) releasing the product from the mold.

20. Use of a polymer as defined in claim 1 for the manufacture of a contact lens.

21. Use of a polymer as defined in claim 1 as oxygen permeable membrane or film or as bandage or drug carrier.