CA2005567A1 - Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system - Google Patents

Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system

Info

Publication number
CA2005567A1
CA2005567A1 CA002005567A CA2005567A CA2005567A1 CA 2005567 A1 CA2005567 A1 CA 2005567A1 CA 002005567 A CA002005567 A CA 002005567A CA 2005567 A CA2005567 A CA 2005567A CA 2005567 A1 CA2005567 A1 CA 2005567A1
Authority
CA
Canada
Prior art keywords
nervous system
central nervous
disease
damage
genetically modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002005567A
Other languages
French (fr)
Other versions
CA2005567C (en
Inventor
Fred H. Gage
Michael B. Rosenberg
John A. Wolff
Theodore Friedman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
Fred H. Gage
Michael B. Rosenberg
John A. Wolff
Theodore Friedman
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fred H. Gage, Michael B. Rosenberg, John A. Wolff, Theodore Friedman, The Regents Of The University Of California filed Critical Fred H. Gage
Publication of CA2005567A1 publication Critical patent/CA2005567A1/en
Application granted granted Critical
Publication of CA2005567C publication Critical patent/CA2005567C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/48—Nerve growth factor [NGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/16—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced pteridine as one donor, and incorporation of one atom of oxygen (1.14.16)
    • C12Y114/16002—Tyrosine 3-monooxygenase (1.14.16.2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
    • C12N2740/13041—Use of virus, viral particle or viral elements as a vector
    • C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines

Abstract

Methods of genetically modifying donor cells by gene transfer for grafting into the central nervous system to treat diseased or damaged cells are disclosed. The modified donor cells produce a molecule capable of affecting the recovery of cells in the CNS. Methods and vectors for carrying out gene transfer and grafting are described.
CA002005567A 1988-12-15 1989-12-14 Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system Expired - Lifetime CA2005567C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US285,196 1988-12-15
US07/285,196 US5082670A (en) 1988-12-15 1988-12-15 Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system

Publications (2)

Publication Number Publication Date
CA2005567A1 true CA2005567A1 (en) 1990-06-15
CA2005567C CA2005567C (en) 2005-07-26

Family

ID=23093180

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002005567A Expired - Lifetime CA2005567C (en) 1988-12-15 1989-12-14 Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system

Country Status (7)

Country Link
US (1) US5082670A (en)
EP (1) EP0449948B1 (en)
JP (1) JPH04503351A (en)
AT (1) ATE184797T1 (en)
CA (1) CA2005567C (en)
DE (1) DE68929077T2 (en)
WO (1) WO1990006757A1 (en)

Families Citing this family (262)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048729A (en) * 1987-05-01 2000-04-11 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6544771B1 (en) 1987-12-11 2003-04-08 Cell Genesys, Inc. Retroviral gene therapy vectors and therapeutic methods based thereon
ATE152169T1 (en) 1988-02-05 1997-05-15 Whitehead Biomedical Inst MODIFIED HEPATOCYTES AND THEIR APPLICATION
US5580776A (en) * 1988-02-05 1996-12-03 Howard Hughes Medical Institute Modified hepatocytes and uses therefor
US5650148A (en) * 1988-12-15 1997-07-22 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
US7238673B2 (en) * 1989-03-31 2007-07-03 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
AU7312891A (en) * 1990-02-12 1991-09-03 Board Of Regents, The University Of Texas System Satellite cell proliferation in adult skeletal muscle
FR2662698A1 (en) * 1990-06-05 1991-12-06 Centre Nat Rech Scient New neurotropic growth factors comprising a homeobox peptide
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US5849572A (en) * 1990-10-10 1998-12-15 Regents Of The University Of Michigan HSV-1 vector containing a lat promoter
US5849571A (en) * 1990-10-10 1998-12-15 University Of Pittsburgh Of The Commonwealth System Of Higher Education Latency active herpes virus promoters and their use
US5618531A (en) * 1990-10-19 1997-04-08 New York University Method for increasing the viability of cells which are administered to the brain or spinal cord
WO1992007945A1 (en) * 1990-10-30 1992-05-14 Dana Farber Cancer Institute Cell type specific alteration of levels of gene products in neural cells
JPH05505944A (en) * 1990-12-26 1993-09-02 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ Modified hepatocytes and their uses
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
DK0585368T3 (en) 1991-04-25 1998-03-16 Univ Brown Res Found Implantable biocompatible immuno-insulating vehicle for delivery of selected therapeutic products
US6497872B1 (en) * 1991-07-08 2002-12-24 Neurospheres Holdings Ltd. Neural transplantation using proliferated multipotent neural stem cells and their progeny
US5981165A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US5980885A (en) * 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. Growth factor-induced proliferation of neural precursor cells in vivo
US6294346B1 (en) 1991-07-08 2001-09-25 Neurospheres Holdings, Ltd. Use of multipotent neural stem cells and their progeny for the screening of drugs and other biological agents
US7361505B1 (en) 1991-07-08 2008-04-22 Neurospheres Holdings Ltd. Multipotent neural stem cell compositions
US6071889A (en) * 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
US7166277B1 (en) * 1991-07-08 2007-01-23 Neurospheres Holdings Ltd. Remyelination of neurons using multipotent neural stem cell progeny
US6399369B1 (en) 1991-07-08 2002-06-04 Neurospheres Holdings Ltd. Multipotent neural stem cell cDNA libraries
US5851832A (en) * 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5750376A (en) * 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US5329846A (en) * 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
US6503277B2 (en) * 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US5529774A (en) * 1991-08-13 1996-06-25 The Regents Of The University Of California In vivo transfer of the HSV-TK gene implanted retroviral producer cells
US6214334B1 (en) * 1991-10-21 2001-04-10 Trustees Of The University Of Pennsylvania Compositions and methods for producing and using homogenous neuronal cell transplants to treat neurodegenerative disorders and brain and spinal cord injuries
NZ245015A (en) 1991-11-05 1995-12-21 Transkaryotic Therapies Inc Delivery of human growth hormone through the administration of transfected cell lines encoding human growth hormone, which are physically protected from host immune response; the transfected cells and their production
US6692737B1 (en) 1991-11-05 2004-02-17 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
US6063630A (en) 1991-11-05 2000-05-16 Transkaryotic Therapies, Inc. Targeted introduction of DNA into primary or secondary cells and their use for gene therapy
US6270989B1 (en) 1991-11-05 2001-08-07 Transkaryotic Therapies, Inc. Protein production and delivery
US5733761A (en) 1991-11-05 1998-03-31 Transkaryotic Therapies, Inc. Protein production and protein delivery
US6054288A (en) * 1991-11-05 2000-04-25 Transkaryotic Therapies, Inc. In vivo protein production and delivery system for gene therapy
DK0625195T3 (en) * 1991-11-15 1999-08-30 Univ California Treatment of the central nervous system with genetically modified cells
WO1993014790A1 (en) * 1992-01-23 1993-08-05 New York University A method for transplanting cells into the brain and therapeutic uses therefor
CA2102519A1 (en) * 1992-03-04 1993-09-05 Jon A. Wolff Method of delivering therapeutic substances to the brain
US6087323A (en) * 1992-04-03 2000-07-11 Cambridge Neuroscience, Inc. Use of neuregulins as modulators of cellular communication
US5688936A (en) * 1992-06-11 1997-11-18 The Regents Of The University Of California Vesicle membrane transport proteins
WO1994001135A1 (en) * 1992-07-06 1994-01-20 The Research Foundation Of State University Of New York Method of producing genetically modified astrocytes and uses thereof
US6670178B1 (en) 1992-07-10 2003-12-30 Transkaryotic Therapies, Inc. In Vivo production and delivery of insulinotropin for gene therapy
US6531124B1 (en) 1992-07-10 2003-03-11 Transkaryotic Therapies, Inc. In vivo production and delivery of insulinotropin for gene therapy
US5266588A (en) * 1992-09-25 1993-11-30 Bristol-Myers Squibb Company Compound produced by a strain of microtetraspora having antibacterial and neuritogenic activity
AU692423B2 (en) * 1992-09-25 1998-06-11 Institut National De La Sante Et De La Recherche Medicale Adenovirus vectors for the transfer of foreign genes into cells of the central nervous system, particularly in brain
US5766948A (en) * 1993-01-06 1998-06-16 The Regents Of The University Of California Method for production of neuroblasts
AU687785B2 (en) * 1993-01-29 1998-03-05 Neurospheres Holdings Ltd Genetic modification of neural stem cells
US5753491A (en) * 1993-04-13 1998-05-19 Us Health Use of neuro-derived fetal cell lines for transplantation therapy
PT696205E (en) * 1993-04-13 2002-07-31 Us Gov Health & Human Serv USE OF NAURO-DERIVED FETAAL CELL LINES FOR TRANSPLANTATION THERAPY
FR2704556B1 (en) * 1993-04-30 1995-07-13 Rhone Poulenc Rorer Sa Recombinant viruses and their use in gene therapy.
FR2707091B1 (en) * 1993-06-30 1997-04-04 Cohen Haguenauer Odile Retroviral vector for gene transfer and expression in eukaryotic cells.
US5908623A (en) * 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
EP1179350A3 (en) * 1993-08-12 2003-01-02 Cytotherapeutics, Inc. Encapsulated cell system for implantation into the human CNS
DE69431993T2 (en) * 1993-11-09 2003-11-27 Neurospheres Holding Ltd IN SITU MODIFICATION AND MANIPULATION OF STEM CELLS OF THE CENTRAL NERVOUS SYSTEM
CA2146735C (en) * 1994-04-11 2007-02-20 Chise Tateno Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes
US5714353A (en) * 1994-05-24 1998-02-03 Research Corporation Technologies, Inc. Safe vectors for gene therapy
FR2721943B1 (en) * 1994-06-29 1996-08-02 Rhone Poulenc Rorer Sa ADENOVIRUS COMPRISING A GENE ENCODING A SUPEROXIDE DISMUTASE
US5858747A (en) * 1994-07-20 1999-01-12 Cytotherapeutics, Inc. Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers
US5935849A (en) * 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5834029A (en) * 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
FR2723588B1 (en) * 1994-08-12 1996-09-20 Rhone Poulenc Rorer Sa ADENOVIRUS COMPRISING A GENE ENCODING GLUTATHIONE PEROXYDASE
US6103226A (en) * 1994-08-12 2000-08-15 Arch Development Corporation Genetically engineered cells that produce produce L. Dopa
AU8122094A (en) * 1994-10-19 1996-05-15 Human Genome Sciences, Inc. Human hypoxanthine-(guanine) phosphoribosyl transferase-2
JP2000503521A (en) 1994-11-02 2000-03-28 トロフィックス ファーマシューティカルズ，インコーポレイテッド Peripheral nervous system specific sodium channel, DNA encoding it, crystallization, X-ray diffraction, computer molecular modeling, rational drug design, drug screening, and methods of making and using the same
US6277372B1 (en) * 1994-11-08 2001-08-21 Diacrin, Inc. Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases
US6204053B1 (en) 1994-11-08 2001-03-20 Diacrin, Inc. Porcine cortical cells and their use in treatment of neurological deficits due to neurodegenerative diseases
US6294383B1 (en) 1994-11-08 2001-09-25 The Mclean Hospital Corporation Porcine neural cells and their use in treatment of neurological deficits due to neurodegenerative diseases
FR2727429B1 (en) 1994-11-30 1997-11-28 Haguenauer Odile Cohen ENCAPSIDATION LINES AND EXPRESSION VECTORS FOR TRANSCOMPLEMENTATION OF DEFECTIVE RETROVIRAL VECTORS
EP1006801A4 (en) * 1995-03-13 2001-05-02 Univ South Florida Sertoli cells as neurorecovery inducing cells for neurodegenerative disorders
US5702700A (en) * 1995-03-13 1997-12-30 University Of South Florida Sertoli cells as neurorecovery inducing cells for Parkinson's disease
US5681744A (en) * 1995-03-17 1997-10-28 Greenstein; Robert J. Delivery and expression of heterologus genes using upstream enhancer regions of mammalian gene promoters
US6974571B2 (en) * 1995-03-28 2005-12-13 Thomas Jefferson University Isolated stromal cells and methods of using the same
US6653134B2 (en) * 1995-03-28 2003-11-25 Cp Hahnemann University Isolated stromal cells for use in the treatment of diseases of the central nervous system
US6576607B1 (en) * 1995-04-19 2003-06-10 Acorda Therapeutics Methods using CNS neurite outgrowth modulators
AU5390696A (en) * 1995-04-20 1996-11-07 University Of South Florida Purified and isolated sertoli cell aggregate
US5849585A (en) * 1995-05-10 1998-12-15 Genetech, Inc. Isolating and culturing Schwann cells
US5721139A (en) * 1995-05-10 1998-02-24 Genentech, Inc. Isolating and culturing schwann cells
US5714385A (en) * 1995-05-10 1998-02-03 Genentech, Inc. Media for culturing schwann cells
US6033660A (en) * 1995-05-10 2000-03-07 Genentech, Inc. Method of treating a nervous system injury with cultured schwann cells
US6495364B2 (en) * 1995-05-23 2002-12-17 Neurotech, S.A. Mx-1 conditionally immortalized cells
WO1996039416A1 (en) * 1995-06-06 1996-12-12 The Trustees Of The University Of Pennsylvania Gene therapy for pituitary adenoma and other endocrine disorders
AU742824C (en) * 1995-06-06 2003-03-20 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The Use of neuro-derived fetal cell lines for transplantation therapy
US6306649B1 (en) * 1995-06-27 2001-10-23 Ariad Gene Therapeutics, Inc. Heterologous transcription factors
US5753505A (en) * 1995-07-06 1998-05-19 Emory University Neuronal progenitor cells and uses thereof
US6267955B1 (en) 1995-09-15 2001-07-31 Yeda Research And Development Co. Ltd. Mononuclear phagocytes and their use to promote axonal regeneration
US5800812A (en) * 1995-09-15 1998-09-01 Yeda Research And Development Co. Ltd. Methods of use of mononuclear phagocytes to promote axonal regeneration
US20020006660A1 (en) * 1996-03-01 2002-01-17 Rhone-Poulenc Rorer, S.A. Genetically-modified neural progenitors and uses thereof
AU1979897A (en) * 1996-03-04 1997-09-22 University Of Medicine And Dentistry Of New Jersey Genetically engineered primary oligodendrocytes for transplantation-mediated gene delivery in the central nervous system
FR2746109B1 (en) 1996-03-12 1998-04-17 Rhone Poulenc Rorer Sa ENVIRONMENT FOR THE CONSERVATION OF BIOLOGICAL MATERIAL
US6037175A (en) * 1996-03-12 2000-03-14 The University Of South Florida Method and media for enhancing cryopreservation of cells
US7544511B2 (en) * 1996-09-25 2009-06-09 Neuralstem Biopharmaceuticals Ltd. Stable neural stem cell line methods
US6759499B1 (en) * 1996-07-16 2004-07-06 Exxonmobil Chemical Patents Inc. Olefin polymerization process with alkyl-substituted metallocenes
US5718717A (en) * 1996-08-19 1998-02-17 Bonutti; Peter M. Suture anchor
US6713247B1 (en) 1996-09-03 2004-03-30 Signal Pharmaceuticials, Inc. Human CNS cell lines and methods of use therefor
US20040086494A1 (en) * 1996-10-07 2004-05-06 John Constance Mary Immune privileged cells for delivery of proteins and peptides
JP2001513643A (en) * 1997-03-06 2001-09-04 ウーベルラ、クラウス Vectors and vector systems based on lentivirus
US7008765B1 (en) * 1997-04-10 2006-03-07 The Johns Hopkins University PCA3, PCA3 genes, and methods of use
IT1292017B1 (en) * 1997-05-28 1999-01-25 Dompe Spa PHARMACEUTICAL COMPOSITIONS CONTAINING MACROPHAGE STIMULATING PROTEIN FOR THE TREATMENT OF NERVOUS SYSTEM PATHOLOGIES
JP2002512627A (en) * 1997-06-11 2002-04-23 アコーダ セラピーティックス CNS nerve regeneration composition and method of using the same
US20030121064A1 (en) * 1997-06-11 2003-06-26 Ann Logan CNS neuroregenerative compositions and methods of use
AU7963998A (en) 1997-06-13 1998-12-30 University Technology Corporation Transplantation of immortalized dopamine cells to improve neurological deficits
WO1999000148A2 (en) * 1997-06-30 1999-01-07 The Regents Of The University Of California Method for treatment of spinal cord injuries in a mammal
US6475230B1 (en) * 1997-08-01 2002-11-05 Peter M. Bonutti Method and apparatus for securing a suture
US20100081197A1 (en) * 1997-08-14 2010-04-01 Sylvie Roux In vivo modulation of neuronal transport
US7923015B2 (en) * 1997-08-14 2011-04-12 Institut Pasteur Methods for direct visualization of active synapses
US7923216B2 (en) * 1997-08-14 2011-04-12 Institut Pasteur In vivo modulation of neuronal transport
EP1049712B1 (en) * 1997-08-14 2007-01-24 Institut Pasteur Hybrid tetanus toxoid proteins that migrate retrogradely and transynaptically into the cns
US5968829A (en) * 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6093531A (en) * 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
US6045551A (en) 1998-02-06 2000-04-04 Bonutti; Peter M. Bone suture
CA2305787A1 (en) * 2000-05-09 2001-11-09 The University Of British Columbia Cxcr4 antagonist treatment of hematopoietic cells
CA2245224A1 (en) * 1998-08-14 2000-02-14 Jiang-Hong Giong Chemokine receptor antagonists and chemotherapeutics
ATE258444T1 (en) * 1998-03-13 2004-02-15 Univ British Columbia THERAPEUTIC CHEMOKINE RECEPTOR ANTAGONISTS
US6815431B2 (en) 1998-04-15 2004-11-09 Regents Of The University Of California Methods for therapy of neurodegenerative disease of the brain
US7157435B2 (en) 1998-04-15 2007-01-02 The Regents Of The University Of California Methods for modulation of the effects of aging on the primate brain
US6451306B1 (en) * 1998-04-15 2002-09-17 The Regents Of The University Of California Methods for therapy of neurodegenerative disease of the brain
US6683058B1 (en) 1998-04-15 2004-01-27 Regents Of The University Of California Methods for therapy of neurodegenerative disease of the brain
WO2002007774A2 (en) * 2000-07-19 2002-01-31 The Regents Of The University Of California Methods for therapy of neurodegenerative disease of the brain
US6027744A (en) * 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
US6171610B1 (en) * 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
US6593133B1 (en) 1998-07-06 2003-07-15 Nsgene A/S Neurotrophic factors
WO2000006700A1 (en) * 1998-07-29 2000-02-10 Layton Bioscience, Inc. Production and use of dopaminergic cells to treat dopaminergic deficiencies
US6444205B2 (en) 1998-09-30 2002-09-03 Diacrin, Inc. Transplantation of neural cells for the treatment of chronic pain or spasticity
US7399751B2 (en) * 1999-11-04 2008-07-15 Sertoli Technologies, Inc. Production of a biological factor and creation of an immunologically privileged environment using genetically altered Sertoli cells
US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
DE19928210B4 (en) * 1999-06-19 2005-08-18 Neuroprogen Gmbh Leipzig Neuronal cell material and method for its production
US6447516B1 (en) 1999-08-09 2002-09-10 Peter M. Bonutti Method of securing tissue
US6368343B1 (en) 2000-03-13 2002-04-09 Peter M. Bonutti Method of using ultrasonic vibration to secure body tissue
PT1222266E (en) 1999-09-29 2006-07-31 Diagnocure Inc PCA3 MESSENGER RNA IN BENEFICIAL AND MALIGNAL PROSTATE TISSUES
US7560275B2 (en) * 1999-12-30 2009-07-14 Vbi Technologies, L.L.C. Compositions and methods for generating skin
US7575921B2 (en) * 1999-12-30 2009-08-18 Vbi Technologies, L.L.C. Spore-like cells and uses thereof
US6635073B2 (en) 2000-05-03 2003-10-21 Peter M. Bonutti Method of securing body tissue
US20050059584A1 (en) * 2002-08-16 2005-03-17 Ahmed Merzouk Novel chemokine mimetics synthesis and their use
US7368425B2 (en) * 2006-03-24 2008-05-06 Chemokine Therapeutics Corp. Cyclic peptides for modulating growth of neo-vessels and their use in therapeutic angiogenesis
US7378098B2 (en) * 2000-04-12 2008-05-27 The University Of British Columbia CXC chemokine receptor 4 agonist peptides
CA2335109A1 (en) * 2000-04-12 2001-10-12 Chemokine Therapeutics Corporation Cxcr4 agonist treatment of hematopoietic cells
AU2001251599B2 (en) * 2000-04-14 2006-03-02 University Of Pittsburgh Soft tissue and bone augmentation and bulking utilizing muscle-derived progenitor cells, compositions and treatments thereof
US7037493B2 (en) 2000-05-01 2006-05-02 Cornell Research Foundation, Inc. Method of inducing neuronal production in the brain and spinal cord
US6897061B1 (en) 2000-06-16 2005-05-24 Spinal Cord Society Transdifferentiation of glial cells
JP4031901B2 (en) * 2000-07-19 2008-01-09 株式会社東芝 Solid-state imaging device
US20020151050A1 (en) * 2000-10-30 2002-10-17 Vacanti Charles A. Isolation of spore-like cells from tissues exposed to extreme conditions
US20060280724A1 (en) * 2000-11-04 2006-12-14 Ferguson Ian A Identification of ligands that enable endocytosis, using in vivo manipulation of neuronal fibers
IL155728A0 (en) * 2000-11-22 2003-11-23 Geron Corp Tolerizing allografts of pluripotent stem cells
US6576464B2 (en) * 2000-11-27 2003-06-10 Geron Corporation Methods for providing differentiated stem cells
US6921665B2 (en) * 2000-11-27 2005-07-26 Roslin Institute (Edinburgh) Selective antibody targeting of undifferentiated stem cells
EP1385938A1 (en) * 2001-04-23 2004-02-04 Nsgene A/S Method and culture medium for producing neural cells expressing tyrosine hydroxylase
US6719765B2 (en) 2001-12-03 2004-04-13 Bonutti 2003 Trust-A Magnetic suturing system and method
WO2003070189A2 (en) * 2002-02-15 2003-08-28 Cornell Research Foundation, Inc. Enhancing neurotrophin-induced neurogenesis by endogenous neural progenitor cells by concurrent overexpression of brain derived neurotrophic factor and an inhibitor of a pro-gliogenic bone morphogenetic protein
AU2003293409A1 (en) 2002-12-09 2004-06-30 Karl K. Johe Method for discovering neurogenic agents
US8293488B2 (en) 2002-12-09 2012-10-23 Neuralstem, Inc. Method for screening neurogenic agents
US8551100B2 (en) 2003-01-15 2013-10-08 Biomet Manufacturing, Llc Instrumentation for knee resection
US7887542B2 (en) * 2003-01-15 2011-02-15 Biomet Manufacturing Corp. Method and apparatus for less invasive knee resection
US7789885B2 (en) * 2003-01-15 2010-09-07 Biomet Manufacturing Corp. Instrumentation for knee resection
US7837690B2 (en) * 2003-01-15 2010-11-23 Biomet Manufacturing Corp. Method and apparatus for less invasive knee resection
ES2427853T3 (en) 2003-02-07 2013-11-04 Diagnocure Inc. Procedure to detect prostate cancer in a sample
WO2004098621A1 (en) * 2003-04-17 2004-11-18 U.S. Department Of Veterans Affairs Isolated/cloned human nt2 cell lines expressing serotonin and gaba
US7459152B2 (en) * 2003-04-23 2008-12-02 Rush University Medical Center Erythropoietin administration to improve graft survival
CN103230415B (en) * 2003-04-25 2016-05-04 匹兹堡大学联邦制高等教育 For promoting and strengthen the neural muscle derived cell (MDC) of repairing and regenerating
WO2005018540A2 (en) * 2003-07-03 2005-03-03 Jannette Dufour Compositions containing sertoli cells and myoid cells and use thereof in cellular transplants
US7326571B2 (en) * 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
US20050013870A1 (en) * 2003-07-17 2005-01-20 Toby Freyman Decellularized extracellular matrix of conditioned body tissues and uses thereof
WO2005033297A1 (en) * 2003-09-19 2005-04-14 The Rockefeller University Compositions, methods and kits relating to reprogramming adult differentiated cells and production of embryonic stem cell-like cells
US20050070379A1 (en) * 2003-09-26 2005-03-31 Todd Gilmour Rite-Hite Golf Tee
US7488324B1 (en) 2003-12-08 2009-02-10 Biomet Manufacturing Corporation Femoral guide for implanting a femoral knee prosthesis
KR101204286B1 (en) 2004-03-30 2012-11-26 엔에스진 에이/에스 Therapeutic use of a growth factor, NsG33
GB2414995B (en) 2004-06-09 2006-11-15 Univ Edinburgh Neural stem cells
US20090136552A1 (en) * 2004-07-30 2009-05-28 Mette Gronborg Growth factors nsg28, nsg30, and nsg32
KR101429284B1 (en) 2004-11-17 2014-08-11 뉴럴스템, 인크. Transplantation of Human Neural Cells for Treatment of Neurodegenerative Conditions
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
CA2491067A1 (en) * 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
CA2596281A1 (en) * 2005-01-31 2006-08-10 Cognate Therapeutics, Inc. Adipose derived adult stromal cells exhibiting characteristics of endothelial cells
US20070092449A1 (en) * 2005-04-05 2007-04-26 Rafael Vazquez-Martinez Methods for direct visualization of active synapses
US7695479B1 (en) 2005-04-12 2010-04-13 Biomet Manufacturing Corp. Femoral sizer
TW200726474A (en) * 2005-07-15 2007-07-16 Cognate Therapeutics Inc The immunophenotype and immunogenicity of human adipose derived cells
US8926959B2 (en) 2005-07-22 2015-01-06 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9274099B2 (en) 2005-07-22 2016-03-01 The Board Of Trustees Of The Leland Stanford Junior University Screening test drugs to identify their effects on cell membrane voltage-gated ion channel
US10052497B2 (en) * 2005-07-22 2018-08-21 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
US9238150B2 (en) * 2005-07-22 2016-01-19 The Board Of Trustees Of The Leland Stanford Junior University Optical tissue interface method and apparatus for stimulating cells
US9278159B2 (en) 2005-07-22 2016-03-08 The Board Of Trustees Of The Leland Stanford Junior University Light-activated cation channel and uses thereof
US20090093403A1 (en) 2007-03-01 2009-04-09 Feng Zhang Systems, methods and compositions for optical stimulation of target cells
US8357666B2 (en) * 2005-08-01 2013-01-22 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through RNA interference
US20070093439A1 (en) * 2005-10-25 2007-04-26 Idera Pharmaceuticals, Inc. Short immunomodulatory oligonucleotides
JP5247468B2 (en) * 2005-12-30 2013-07-24 ニューロテック ユーエスエー， インコーポレイテッド Micronized device for delivery of bioactive molecules and method of use thereof
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
US8603180B2 (en) 2006-02-27 2013-12-10 Biomet Manufacturing, Llc Patient-specific acetabular alignment guides
US9339278B2 (en) 2006-02-27 2016-05-17 Biomet Manufacturing, Llc Patient-specific acetabular guides and associated instruments
TWI501774B (en) 2006-02-27 2015-10-01 Biogen Idec Inc Treatments for neurological disorders
US9345548B2 (en) 2006-02-27 2016-05-24 Biomet Manufacturing, Llc Patient-specific pre-operative planning
US9918740B2 (en) 2006-02-27 2018-03-20 Biomet Manufacturing, Llc Backup surgical instrument system and method
US9113971B2 (en) 2006-02-27 2015-08-25 Biomet Manufacturing, Llc Femoral acetabular impingement guide
US8070752B2 (en) * 2006-02-27 2011-12-06 Biomet Manufacturing Corp. Patient specific alignment guide and inter-operative adjustment
US10278711B2 (en) 2006-02-27 2019-05-07 Biomet Manufacturing, Llc Patient-specific femoral guide
US9173661B2 (en) 2006-02-27 2015-11-03 Biomet Manufacturing, Llc Patient specific alignment guide with cutting surface and laser indicator
US8591516B2 (en) 2006-02-27 2013-11-26 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US7780672B2 (en) * 2006-02-27 2010-08-24 Biomet Manufacturing Corp. Femoral adjustment device and associated method
US20150335438A1 (en) 2006-02-27 2015-11-26 Biomet Manufacturing, Llc. Patient-specific augments
US9289253B2 (en) 2006-02-27 2016-03-22 Biomet Manufacturing, Llc Patient-specific shoulder guide
US9907659B2 (en) 2007-04-17 2018-03-06 Biomet Manufacturing, Llc Method and apparatus for manufacturing an implant
US8407067B2 (en) 2007-04-17 2013-03-26 Biomet Manufacturing Corp. Method and apparatus for manufacturing an implant
US20100030102A1 (en) * 2006-05-15 2010-02-04 David Poston Active Delivery and Flow Redirections: Novel Devices and Method of Delivery of Materials to Patients
US7998128B2 (en) 2006-05-15 2011-08-16 Therataxis, LLC. Active delivery and flow redirection: novel devices and method of delivery of materials to patients
US7695520B2 (en) * 2006-05-31 2010-04-13 Biomet Manufacturing Corp. Prosthesis and implementation system
US20110287010A1 (en) 2006-06-07 2011-11-24 Otago Innovation Limited Diagnostic methods and markers
US9795399B2 (en) 2006-06-09 2017-10-24 Biomet Manufacturing, Llc Patient-specific knee alignment guide and associated method
US9717775B2 (en) 2006-07-18 2017-08-01 University Of Utah Research Foundation Methods for treating pain and screening analgesic compounds
WO2008086470A1 (en) 2007-01-10 2008-07-17 The Board Of Trustees Of The Leland Stanford Junior University System for optical stimulation of target cells
DK2114167T3 (en) 2007-01-16 2018-09-17 Univ Rochester NON-HUMAN ANIMALS WITH HUMAN GLIAKIMARY BRAIN
WO2008101128A1 (en) * 2007-02-14 2008-08-21 The Board Of Trustees Of The Leland Stanford Junior University System, method and applications involving identification of biological circuits such as neurological characteristics
WO2008134406A1 (en) * 2007-04-25 2008-11-06 The Board Of Trustees Of The Leland Stanford Junior University Ischemia-induced neovascularization is enhanced by hcns-sc transplantation
US10434327B2 (en) * 2007-10-31 2019-10-08 The Board Of Trustees Of The Leland Stanford Junior University Implantable optical stimulators
US10035027B2 (en) * 2007-10-31 2018-07-31 The Board Of Trustees Of The Leland Stanford Junior University Device and method for ultrasonic neuromodulation via stereotactic frame based technique
CN102083968A (en) 2008-04-07 2011-06-01 纽珀滕索有限公司 Reprogramming a cell by inducing a pluripotent gene through use of a small molecule modulator
JP5801188B2 (en) 2008-04-23 2015-10-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー Systems, methods, and compositions for photostimulating target cells
US8729040B2 (en) * 2008-05-29 2014-05-20 The Board Of Trustees Of The Leland Stanford Junior University Cell line, system and method for optical control of secondary messengers
MY162929A (en) * 2008-06-17 2017-07-31 Univ Leland Stanford Junior Apparatus and methods for controlling cellular development
CA2728238C (en) 2008-06-17 2019-03-12 M. Bret Schneider Methods, systems and devices for optical stimulation of target cells using an optical transmission element
WO2010006049A1 (en) 2008-07-08 2010-01-14 The Board Of Trustees Of The Leland Stanford Junior University Materials and approaches for optical stimulation of the peripheral nervous system
NZ602416A (en) 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto
CN102325878A (en) 2008-12-23 2012-01-18 斯特姆塞尔思加利福尼亚有限公司 Target populations of oligodendrocyte precursor cells and methods of making and using same
US9511093B2 (en) * 2009-03-23 2016-12-06 The Texas A & M University System Compositions of mesenchymal stem cells to regenerate bone
BRPI0902039B8 (en) 2009-06-09 2021-05-25 Anhanguera Educacional Ltda pharmaceutical composition and use of pharmaceutical composition for the treatment, prophylaxis or prevention of neoplastic diseases in humans and animals
US8288158B2 (en) * 2009-06-12 2012-10-16 Board Of Regents, The University Of Texas System Stem cells modified to facilitate threonine catabolism
CA2780549C (en) 2009-11-12 2017-01-03 Vbi Technologies, L.L.C. Subpopulations of spore-like cells and uses thereof
WO2011116238A2 (en) 2010-03-17 2011-09-22 The Board Of Trustees Of The Leland Stanford Junior University. Light-sensitive ion-passing molecules
AU2011282642B2 (en) 2010-07-28 2015-06-11 Shinn-Zong Lin Methods for treating and/or reversing neurodegenerative diseases and/or disorders
CN108079279B (en) 2010-10-01 2022-04-12 霍巴治疗公司 Use of nickel-line protein for treating allodynia, hyperalgesia, spontaneous pain and phantom pain
AU2011323199B2 (en) 2010-11-05 2016-01-28 The Board Of Trustees Of The Leland Stanford Junior University Stabilized step function opsin proteins and methods of using the same
CA2817175C (en) 2010-11-05 2019-09-24 The Board Of Trustees Of The Leland Stanford Junior University Upconversion of light using lanthanide-doped nanoparticles for use in optogenetic methods
CN103476456B (en) 2010-11-05 2017-10-03 斯坦福大学托管董事会 Award the light Genetic control of corelation behaviour
US10086012B2 (en) 2010-11-05 2018-10-02 The Board Of Trustees Of The Leland Stanford Junior University Control and characterization of memory function
CN106106368A (en) 2010-11-05 2016-11-16 斯坦福大学托管董事会 Optically-controlledCNS CNS dysfunction
EP2635108B1 (en) 2010-11-05 2019-01-23 The Board of Trustees of the Leland Stanford Junior University Light-activated chimeric opsins and methods of using the same
US8696722B2 (en) 2010-11-22 2014-04-15 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic magnetic resonance imaging
US9968376B2 (en) 2010-11-29 2018-05-15 Biomet Manufacturing, Llc Patient-specific orthopedic instruments
US9241745B2 (en) 2011-03-07 2016-01-26 Biomet Manufacturing, Llc Patient-specific femoral version guide
EP2791333B1 (en) 2011-12-16 2019-03-06 The Board of Trustees of the Leland Stanford Junior University Opsin polypeptides and methods of use thereof
US20140024701A1 (en) 2012-02-21 2014-01-23 Circuit Therapeutics, Inc. Compositions and Methods for Treating Neurogenic Disorders of the Pelvic Floor
US9636380B2 (en) 2013-03-15 2017-05-02 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of inputs to the ventral tegmental area
US9790468B2 (en) 2013-03-15 2017-10-17 Avita Iinternational Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications
CA2906756A1 (en) 2013-03-15 2014-09-18 The Board Of Trustees Of The Leland Stanford Junior University Optogenetic control of behavioral state
EP2989198A4 (en) 2013-04-26 2016-10-26 Sloan Kettering Inst Cancer Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells
CA2908864A1 (en) 2013-04-29 2014-11-06 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems and methods for optogenetic modulation of action potentials in target cells
WO2014194284A1 (en) 2013-05-31 2014-12-04 Mcintosh J Michael Conotoxin peptides, pharmaceutical compositions and uses thereof
US9982236B2 (en) 2013-06-13 2018-05-29 Orgenesis Ltd. Cell populations, methods of transdifferentiation and methods of use thereof
CN105829538A (en) 2013-08-14 2016-08-03 小利兰·斯坦福大学托管委员会 Silicone-modified polyester coating
US10779519B2 (en) 2014-05-13 2020-09-22 University Of Rochester Human glial chimeric model for drug candidate assessment in human gliotrophic viral infections and progressive multifocal encephalopathy
KR20190060016A (en) 2014-10-20 2019-05-31 뉴럴스템, 인크. Stable neural stem cells comprising an exogenous polynucleotide coding for a growth factor and methods of use thereof
MA41296A (en) 2014-12-30 2017-11-07 Orgenesis Ltd TRANSDIFFERENTIATION PROCESSES AND METHODS FOR USING THE SAME
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
WO2016209654A1 (en) 2015-06-22 2016-12-29 The Board Of Trustees Of The Leland Stanford Junior University Methods and devices for imaging and/or optogenetic control of light-responsive neurons
US10722310B2 (en) 2017-03-13 2020-07-28 Zimmer Biomet CMF and Thoracic, LLC Virtual surgery planning system and method
US11294165B2 (en) 2017-03-30 2022-04-05 The Board Of Trustees Of The Leland Stanford Junior University Modular, electro-optical device for increasing the imaging field of view using time-sequential capture
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. Transdifferentiated cell populations and methods of use thereof
US20220062378A1 (en) 2018-06-21 2022-03-03 University Of Rochester Methods of treating or inhibiting onset of huntington's disease
US20230057355A1 (en) 2019-02-13 2023-02-23 University Of Rochester Gene networks that mediate remyelination of the human brain
AU2022269279A1 (en) 2021-05-06 2023-11-30 Hoba Therapeutics Aps Prevention and treatment of chemotherapy-induced neuropathic pain
US20230277600A1 (en) 2021-10-20 2023-09-07 University Of Rochester Treatment Of Age-Related White Matter Loss By Competitive Replacement Of Glial Cells
WO2023069843A1 (en) 2021-10-20 2023-04-27 University Of Rochester Humanized chimeras for the prospective assessment of cell addition and replacement therapies
WO2023081633A1 (en) 2021-11-02 2023-05-11 University Of Rochester Tcf7l2 mediated remyelination in the brain
WO2023104960A1 (en) 2021-12-10 2023-06-15 Hoba Therapeutics Aps Treatment of nociceptive pain
WO2023215455A1 (en) 2022-05-05 2023-11-09 University Of Rochester Dual macroglial-microglial approach towards therapeutic cell replacement in neurodegenerative and neuropsychiatric disease

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4497796A (en) * 1980-03-26 1985-02-05 The Regents Of The University Of California Gene transfer in intact mammals

Also Published As

Publication number Publication date
DE68929077T2 (en) 2000-05-25
JPH04503351A (en) 1992-06-18
EP0449948B1 (en) 1999-09-22
DE68929077D1 (en) 1999-10-28
EP0449948A1 (en) 1991-10-09
WO1990006757A1 (en) 1990-06-28
EP0449948A4 (en) 1991-11-13
CA2005567C (en) 2005-07-26
ATE184797T1 (en) 1999-10-15
US5082670A (en) 1992-01-21

Similar Documents

Publication Publication Date Title
CA2005567A1 (en) Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system
CA2095300A1 (en) Use of genetically modified cells to treat defects, disease or damage of the central nervous system
AU3107689A (en) Regeneration of graminaceous plants of the subfamily pooideae from protoplasts
EP0349220A3 (en) Phosphate buffer wash for improved amidoperoxyacid storage stability
ZA884173B (en) Fermentation process
ZA792366B (en) Enzymic microbiological process for producing optically active aminoacids starting from hydanthoins and/or recemic carbamoyl derivatives
AU695398B2 (en) Method of production of transgenic plants wholly transformed into To generation, from meristems
IN151515B (en)
AU5391886A (en) Method and device for the in vitro culture of plant cells and organs, as well as for the micropropagation and regeneration of complete plants
NO872766D0 (en) HYDRAULIC RETRIEVER FOR REPLACEMENT OF SUBSEARS / SENSORS INCLUDED IN PUTS AND TANKING SYSTEMS WHICH ARE UNDER PRESSURE.
GR3021040T3 (en) Process for production of stranger protein in streptomycetes
WO1998036636A3 (en) Method for generating embryogenic cell cultures for the production of bananas (musa spp.)
CS307284A2 (en) Zpusob vyroby poliferujicich rostlinnych bunecnych shluku
AU1551988A (en) Growth promoter for bifidobacterium species, process for preparing the same and method of using the same
NO178036C (en) Process for Preparation of Fusion Proteins, Gene Structure, Vectors of Streptomycet Cells and the Fusion Proteins
AR242989A1 (en) A method for modifying a wild strain of a "shigella", in order to produce a modified strain suitable for preparing a vaccine against the wild strain, and a "shigella" strain thus modified.
AU6284090A (en) Somatic embryogenesis of squash
EP0356258A3 (en) Processes for the lyophilization of red blood cells, together with media for lyophilization
TR28664A (en) Water soluble phthalocyanine dyestuffs, the method for their production and their use.
AU572502B2 (en) Plant structural gene expression using dna vectors and t-dna
Rolandi A practical approach to knowledge engineering.
TR27659A (en) Water soluble phthalocyanine dyestuffs, the method for their production and their use.
ES2000404A6 (en) Transformation method for the actinomycete Streptomyces wadayamensis
Barsomian et al. Endo F-free PNGase
CA2004378A1 (en) Method for increasing the ability of a plant species to undergo androgenesis, and products produced therefrom

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry