CA2006105A1 - Method for the treatment of periodontal disease by sustained delivery of a pharmaceutical agent to the crevicular pocket, composition of matter therefor and apparatus for the administration thereof - Google Patents

Method for the treatment of periodontal disease by sustained delivery of a pharmaceutical agent to the crevicular pocket, composition of matter therefor and apparatus for the administration thereof

Info

Publication number
CA2006105A1
CA2006105A1 CA2006105A CA2006105A CA2006105A1 CA 2006105 A1 CA2006105 A1 CA 2006105A1 CA 2006105 A CA2006105 A CA 2006105A CA 2006105 A CA2006105 A CA 2006105A CA 2006105 A1 CA2006105 A1 CA 2006105A1
Authority
CA
Canada
Prior art keywords
administration
treatment
composition
pharmaceutical agent
periodontal disease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2006105A
Other languages
French (fr)
Other versions
CA2006105C (en
Inventor
Nancy S. Brizzolara
Michael G. Lanzilotti
James R. Lawter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of CA2006105A1 publication Critical patent/CA2006105A1/en
Application granted granted Critical
Publication of CA2006105C publication Critical patent/CA2006105C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)

Abstract

Oral compositions for the local administration of a therapeutic agent to a periodontal pocket of a patient for alleviating dental disease comprise a plurality of dry, discrete microparticles each of which comprise an effective amount of at least one therapeutic agent dispersed in a matrix comprising a biocompatible and biodegradable polymer. Apparatus and methods are also provided for the dispensing of the dry microparticles to the periodontal pocket whereby they become tacky and adhere to the involved tissue so as to induce long term therapeutic benefits.
CA002006105A 1988-12-22 1989-12-20 Method for the treatment of periodontal disease by sustained delivery of a pharmaceutical agent to the crevicular pocket, composition of matter therefor and apparatus for the administration thereof Expired - Lifetime CA2006105C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28907688A 1988-12-22 1988-12-22
US07/289,076 1988-12-22

Publications (2)

Publication Number Publication Date
CA2006105A1 true CA2006105A1 (en) 1990-06-22
CA2006105C CA2006105C (en) 2000-03-14

Family

ID=23109956

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002006105A Expired - Lifetime CA2006105C (en) 1988-12-22 1989-12-20 Method for the treatment of periodontal disease by sustained delivery of a pharmaceutical agent to the crevicular pocket, composition of matter therefor and apparatus for the administration thereof

Country Status (16)

Country Link
US (1) US5366733A (en)
EP (1) EP0374531B1 (en)
JP (1) JP2901674B2 (en)
KR (2) KR0143912B1 (en)
AT (1) ATE105177T1 (en)
AU (1) AU635912B2 (en)
CA (1) CA2006105C (en)
DE (1) DE68915132T2 (en)
DK (1) DK174915B1 (en)
ES (1) ES2051968T3 (en)
IE (1) IE63952B1 (en)
IL (1) IL92700A (en)
NO (1) NO178605C (en)
NZ (1) NZ231791A (en)
PT (1) PT92614B (en)
ZA (1) ZA899857B (en)

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FR2673843B1 (en) * 1991-03-14 1995-01-13 Centre Nat Rech Scient IMPLANTABLE, BIORESORBABLE PHARMACEUTICAL COMPOSITION BASED ON POLY (LACTIC ACID), INTENDED TO IMPLEMENT A LOCAL INTERNAL ANTIBOTHERAPY.
ATE175132T1 (en) * 1992-10-26 1999-01-15 Sanol Arznei Schwarz Gmbh METHOD FOR PRODUCING MICRO CAPSULES
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US6074840A (en) 1994-02-18 2000-06-13 The Regents Of The University Of Michigan Recombinant production of latent TGF-beta binding protein-3 (LTBP-3)
US5763416A (en) 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
WO1996002275A1 (en) * 1994-07-20 1996-02-01 Toyama Chemical Co., Ltd. Sustained-release oral ointment
US5660817A (en) 1994-11-09 1997-08-26 Gillette Canada, Inc. Desensitizing teeth with degradable particles
US5612052A (en) * 1995-04-13 1997-03-18 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6551610B2 (en) 1995-04-13 2003-04-22 Poly-Med, Inc. Multifaceted compositions for post-surgical adhesion prevention
US6413539B1 (en) 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
US6416714B1 (en) * 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6270795B1 (en) 1995-11-09 2001-08-07 Microbiological Research Authority Method of making microencapsulated DNA for vaccination and gene therapy
EP0862419B2 (en) 1995-11-09 2010-11-17 Microbiological Research Authority Microencapsulated dna for vaccination and gene therapy
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US6406719B1 (en) 1998-05-13 2002-06-18 Microbiological Research Authority Encapsulation of bioactive agents
GB9810236D0 (en) 1998-05-13 1998-07-08 Microbiological Res Authority Improvements relating to encapsulation of bioactive agents
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
US20050037086A1 (en) * 1999-11-19 2005-02-17 Zycos Inc., A Delaware Corporation Continuous-flow method for preparing microparticles
DE10018221A1 (en) * 2000-04-12 2001-11-22 Fitzner Lothar Treating disorders of the teeth, gums or jawbones using growth hormones, preferably human growth hormone or dehydroepiandrosterone, useful e.g. for treating paradontosis or healing jaw operation wounds
EP1292285A4 (en) * 2000-06-02 2009-07-22 Eisai Corp North America Delivery systems for bioactive agents
JP2002128697A (en) * 2000-10-20 2002-05-09 Nonomura Tomosuke Treating and preventing agent for oral cavity
US6576226B1 (en) * 2000-11-17 2003-06-10 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6726898B2 (en) 2000-11-17 2004-04-27 Gary R. Jernberg Local delivery of agents for disruption and inhibition of bacterial biofilm for treatment of periodontal disease
US6610274B1 (en) * 2000-12-22 2003-08-26 Wallace J. Gardner Anti-inflammatory composition comprising tetracycline
US20040029842A1 (en) * 2001-12-18 2004-02-12 Gardner Wallace J. Triglyceride lowering, common cold and pneumonia prevention composition comprising tetracycline, and methods of treating or preventing diseases using same
US6682348B2 (en) 2002-03-29 2004-01-27 Orapharma, Inc. Dispensing apparatus and cartridge
US6958161B2 (en) 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
CA2518667C (en) 2003-03-14 2011-07-19 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US20040185009A1 (en) * 2003-03-19 2004-09-23 Dexcel Pharma Technologies Ltd. Composition and device for treating periodontal diseases
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US20050079187A1 (en) * 2003-10-14 2005-04-14 Gardner Wallace J. Composition, kit and method for reducing plaque formation, tooth decay and incidence of caries
JP2010506599A (en) 2006-05-22 2010-03-04 ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティ オブ ニューヨーク A method for exchanging components between a first fluid and a second fluid, a method for cleaning a first component from a first fluid, a blood processing method, a fluid treatment device, a first fluid and first and second components Apparatus for exchanging components with second fluid, apparatus for exchanging components between first fluid and second fluid, and method for separating blood cells from plasma
US20090081135A1 (en) * 2007-09-24 2009-03-26 Glen Jeffrey D Iodine-based oral antibacterial treatment methodology
US7976491B2 (en) * 2007-12-04 2011-07-12 Orapharma, Inc. Actuators for device for delivering medicinal implants
US7976490B2 (en) * 2007-12-04 2011-07-12 Orapharma, Inc. Medicinal implant cartridge
US7976489B2 (en) 2007-12-04 2011-07-12 Orapharma, Inc. Device for delivering medicinal implants
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US9402701B2 (en) 2013-10-22 2016-08-02 Profounda, Inc Positionable delivery device and method
US11147747B2 (en) * 2018-04-05 2021-10-19 Terrell F. Pannkuk Composition and method for endodontic debridement
US11571367B2 (en) * 2018-04-05 2023-02-07 Terrell F. Pannkuk Composition and method for endodontic debridement

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Also Published As

Publication number Publication date
IL92700A (en) 1994-05-30
DK655889A (en) 1990-06-23
DE68915132D1 (en) 1994-06-09
JPH02184620A (en) 1990-07-19
ATE105177T1 (en) 1994-05-15
KR0138651B1 (en) 1998-05-15
CA2006105C (en) 2000-03-14
NO178605B (en) 1996-01-22
EP0374531A2 (en) 1990-06-27
NO895167L (en) 1990-06-25
NO178605C (en) 1996-05-02
AU635912B2 (en) 1993-04-08
DE68915132T2 (en) 1994-12-08
PT92614A (en) 1990-06-29
US5366733A (en) 1994-11-22
NO895167D0 (en) 1989-12-21
KR0143912B1 (en) 1998-07-15
KR900009061A (en) 1990-07-02
DK655889D0 (en) 1989-12-21
EP0374531B1 (en) 1994-05-04
NZ231791A (en) 1992-05-26
IE894145L (en) 1990-06-22
DK174915B1 (en) 2004-02-23
AU4707789A (en) 1990-06-28
JP2901674B2 (en) 1999-06-07
ZA899857B (en) 1990-10-31
EP0374531A3 (en) 1991-07-31
PT92614B (en) 1995-09-12
KR900009045A (en) 1990-07-02
ES2051968T3 (en) 1994-07-01
IE63952B1 (en) 1995-06-28
IL92700A0 (en) 1990-09-17

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Legal Events

Date Code Title Description
EEER Examination request
FZDC Discontinued application reinstated
MKEX Expiry