CA2007776A1 - Phase modulated spectrophotometry - Google Patents

Phase modulated spectrophotometry

Info

Publication number
CA2007776A1
CA2007776A1 CA2007776A CA2007776A CA2007776A1 CA 2007776 A1 CA2007776 A1 CA 2007776A1 CA 2007776 A CA2007776 A CA 2007776A CA 2007776 A CA2007776 A CA 2007776A CA 2007776 A1 CA2007776 A1 CA 2007776A1
Authority
CA
Canada
Prior art keywords
time
concentration
spectrophotometry
phase modulation
phase modulated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2007776A
Other languages
French (fr)
Other versions
CA2007776C (en
Inventor
Britton Chance
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Non Invasive Technology Inc
Original Assignee
Britton Chance
Nim Incorporated
Ip Company
Non-Invasive Technology, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Britton Chance, Nim Incorporated, Ip Company, Non-Invasive Technology, Inc. filed Critical Britton Chance
Publication of CA2007776A1 publication Critical patent/CA2007776A1/en
Application granted granted Critical
Publication of CA2007776C publication Critical patent/CA2007776C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/47—Scattering, i.e. diffuse reflection
    • G01N21/49—Scattering, i.e. diffuse reflection within a body or fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14551—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases
    • A61B5/14553—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters for measuring blood gases specially adapted for cerebral tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J9/00—Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength
    • G01J9/04—Measuring optical phase difference; Determining degree of coherence; Measuring optical wavelength by beating two waves of a same source but of different frequency and measuring the phase shift of the lower frequency obtained
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N2021/1789—Time resolved
    • G01N2021/1791—Time resolved stroboscopic; pulse gated; time range gated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G01N2201/06113—Coherent sources; lasers

Abstract

The present invention to provides methods and apparatus for studying photon migration using signal modulation techniques such as time, frequency and phase modulation. The photon migration data may then be converted, using the principles of time-resolved spectroscopy, to determine the concentration of an absorptive constituent in a scattering medium, such as the concentration of hemoglobin in a brain of other tissue. The methods and apparatus disclosed provide as a specific embodiment, a dual wavelength phase modulation system which allows the clinical application of the advantages of time resolved spectroscopy in an economical and commercially feasible embodiment.
CA002007776A 1989-02-06 1990-01-15 Phase modulated spectrophotometry Expired - Lifetime CA2007776C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US307,066 1989-02-06
US07/307,066 US4972331A (en) 1989-02-06 1989-02-06 Phase modulated spectrophotometry

Publications (2)

Publication Number Publication Date
CA2007776A1 true CA2007776A1 (en) 1990-08-06
CA2007776C CA2007776C (en) 1999-11-02

Family

ID=23188100

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002007776A Expired - Lifetime CA2007776C (en) 1989-02-06 1990-01-15 Phase modulated spectrophotometry

Country Status (6)

Country Link
US (1) US4972331A (en)
EP (1) EP0456637A4 (en)
JP (1) JP2947568B2 (en)
CA (1) CA2007776C (en)
SG (1) SG64313A1 (en)
WO (1) WO1990009003A1 (en)

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JPH02234048A (en) 1990-09-17
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US4972331A (en) 1990-11-20
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