CA2009570A1 - Electrotransport adhesive - Google Patents

Electrotransport adhesive

Info

Publication number
CA2009570A1
CA2009570A1 CA2009570A CA2009570A CA2009570A1 CA 2009570 A1 CA2009570 A1 CA 2009570A1 CA 2009570 A CA2009570 A CA 2009570A CA 2009570 A CA2009570 A CA 2009570A CA 2009570 A1 CA2009570 A1 CA 2009570A1
Authority
CA
Canada
Prior art keywords
adhesive
delivery device
iontophoretic delivery
phase
electrotransport
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2009570A
Other languages
French (fr)
Other versions
CA2009570C (en
Inventor
J. Richard Gyory
Ronald P. Haak
Felix Theeuwes
Patrick J. Lew
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
J. Richard Gyory
Ronald P. Haak
Felix Theeuwes
Patrick J. Lew
Alza Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by J. Richard Gyory, Ronald P. Haak, Felix Theeuwes, Patrick J. Lew, Alza Corporation filed Critical J. Richard Gyory
Publication of CA2009570A1 publication Critical patent/CA2009570A1/en
Application granted granted Critical
Publication of CA2009570C publication Critical patent/CA2009570C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
    • C09J133/04—Homopolymers or copolymers of esters
    • C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09J—ADHESIVES; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; USE OF MATERIALS AS ADHESIVES
    • C09J201/00—Adhesives based on unspecified macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A61N1/0496—Patch electrodes characterised by using specific chemical compositions, e.g. hydrogel compositions, adhesives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/04—Polymer mixtures characterised by other features containing interpenetrating networks
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
    • C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2666/00—Composition of polymers characterized by a further compound in the blend, being organic macromolecular compounds, natural resins, waxes or and bituminous materials, non-macromolecular organic substances, inorganic substances or characterized by their function in the composition
    • C08L2666/02—Organic macromolecular compounds, natural resins, waxes or and bituminous materials
    • C08L2666/04—Macromolecular compounds according to groups C08L7/00 - C08L49/00, or C08L55/00 - C08L57/00; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S524/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S524/925—Natural rubber compositions having nonreactive materials, i.e. NRM, other than: carbon, silicon dioxide, glass titanium dioxide, water, hydrocarbon or halohydrocarbon
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/931—Blend of stated incompatibility
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/937—Utility as body contact e.g. implant, contact lens or I.U.D.
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S525/00—Synthetic resins or natural rubbers -- part of the class 520 series
    • Y10S525/941—Polymer mixture containing block copolymer is mixed or reacted with chemical treating agent

Abstract

ELECTROTRANSPORT ADHESIVE

ABSTRACT OF THE DISCLOSURE

A two phase adhesive matrix for use in an electrically powered iontophoretic delivery device is provided. The adhesive matrix comprises an adhesive hydrophobic polymer phase and about 15 to 60 wt% on a dry weight basis of a hydrophilio polymer phase distributed through the hydrophobic polymer phase. The hydrophilic phase forms upon hydration an interconnecting network of aqueous pathways for passage of the agent through the adhesive. The adhesive can be used to adhere an electrode assembly of an iontophoretic delivery device to a body surface such as skin or a mucosal membrane. Alternatively, the adhesive can be used to adhere together two or more elements of an iontophoretic delivery device.
CA002009570A 1989-02-09 1990-02-08 Electrotransport adhesive Expired - Lifetime CA2009570C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/308,716 US5234992A (en) 1989-02-09 1989-02-09 Electrotransport adhesive
US308,716 1989-02-09

Publications (2)

Publication Number Publication Date
CA2009570A1 true CA2009570A1 (en) 1990-08-09
CA2009570C CA2009570C (en) 2000-04-18

Family

ID=23195103

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002009570A Expired - Lifetime CA2009570C (en) 1989-02-09 1990-02-08 Electrotransport adhesive

Country Status (14)

Country Link
US (1) US5234992A (en)
EP (1) EP0457849B1 (en)
JP (1) JP2885510B2 (en)
AT (1) ATE125856T1 (en)
AU (1) AU630946B2 (en)
CA (1) CA2009570C (en)
DE (1) DE69021375T2 (en)
DK (2) DK0457849T3 (en)
ES (1) ES2027093A6 (en)
GR (1) GR1000540B (en)
IE (1) IE68881B1 (en)
NZ (1) NZ232431A (en)
PT (1) PT93096B (en)
WO (1) WO1990009413A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5158537A (en) * 1990-10-29 1992-10-27 Alza Corporation Iontophoretic delivery device and method of hydrating same
WO1992007618A1 (en) * 1990-10-29 1992-05-14 Alza Corporation Iontophoretic drug delivery electrode and method of hydrating the same
AU652494B2 (en) * 1991-11-15 1994-08-25 Minnesota Mining And Manufacturing Company Solid state conductive polymer compositions, biomedical electrodes containing such compositions, and method of preparing same
ZA933819B (en) 1992-06-02 1994-01-05 Alza Corp Iontophoretic drug delivery apparatus
US5380271A (en) * 1992-09-24 1995-01-10 Alza Corporation Electrotransport agent delivery device and method
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
GB9816826D0 (en) * 1998-07-31 1998-09-30 First Water Ltd Bioadhesive compositions
WO1997048444A1 (en) * 1996-06-19 1997-12-24 Becton Dickinson And Company Iontophoretic delivery of cell adhesion inhibitors
JP2002521526A (en) * 1998-07-31 2002-07-16 ファースト ウォーター リミテッド Bioadhesive composition containing hydrophobic polymer
GB9902238D0 (en) * 1999-02-02 1999-03-24 First Water Ltd Bioadhesive compositions
US6347246B1 (en) * 2000-02-03 2002-02-12 Axelgaard Manufacturing Company, Ltd. Electrotransport adhesive for iontophoresis device
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US20050274455A1 (en) * 2004-06-09 2005-12-15 Extrand Charles W Electro-active adhesive systems
WO2007092290A2 (en) * 2006-02-02 2007-08-16 H.B. Fuller Licensing & Financing, Inc. Conductive articles including hot melt superabsorbent polymer composition and method of making and method of using the same
US7761131B2 (en) * 2006-05-30 2010-07-20 Tyco Healthcare Group Lp Medical electrode containing a hydrophilic polymer
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
EP2164418B1 (en) 2007-06-27 2014-01-08 The General Hospital Corporation Apparatus for optical inhibition of photodynamic therapy
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
US8419982B2 (en) * 2008-09-11 2013-04-16 Covidien Lp Conductive compositions and method
US8548557B2 (en) 2010-08-12 2013-10-01 Covidien Lp Medical electrodes
CN106413695B (en) 2014-04-08 2019-12-10 帝国制药美国公司 Rivastigmine transdermal compositions and methods of use thereof

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DK121137C (en) * 1967-02-17 1976-07-05 Pierrel Spa IN THE ESSENTIAL UNDERGROUND, FOR THE CONTENT OF MEDICINES, SKIN OR SILM TREATMENT PRODUCTS OR DISINFECTANTS IN CONTACT WITH SKIN OR MUSCLE
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Also Published As

Publication number Publication date
JP2885510B2 (en) 1999-04-26
GR1000540B (en) 1992-08-25
IE900432L (en) 1990-08-09
CA2009570C (en) 2000-04-18
WO1990009413A1 (en) 1990-08-23
ES2027093A6 (en) 1992-05-16
NZ232431A (en) 1992-04-28
GR900100081A (en) 1991-06-28
JPH04504136A (en) 1992-07-23
ATE125856T1 (en) 1995-08-15
DK0457849T3 (en) 1995-09-11
DK33790D0 (en) 1990-02-08
DE69021375D1 (en) 1995-09-07
DK33790A (en) 1990-08-10
PT93096B (en) 1998-04-30
PT93096A (en) 1990-08-31
AU5332990A (en) 1990-09-05
IE68881B1 (en) 1996-07-24
AU630946B2 (en) 1992-11-12
DE69021375T2 (en) 1996-01-25
EP0457849B1 (en) 1995-08-02
EP0457849A1 (en) 1991-11-27
US5234992A (en) 1993-08-10

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