CA2020557A1 - Topically administrable pharmaceutical preparations - Google Patents

Abstract

4-17658/+

Topically administrable pharmaceutical preparations Abstract The invention relates to topically administrable pharmaceutical preparations containing pharmaceudcally acceptable methanediphosphonic acid derivatives of formula

Description

4-1765~/+

Topically administrable pharmaceutical preparations Xt is known that representatives of a class of synthetic methanediphosphonic acid derivatives are used, for e~ample, in the treatment of osteolytic bone metastases and hypercalcaemia, since they are able to inhibit the growth and decomposition of hydroxyapatite. These compounds thus prevent bone resorption by binding spontaneously to the hydroxyapatite of the bone, so that osteoclasts, for example, are unable to cleave further hydroxyapatite crystals. Compounds of this class of substances are described, for example, in DE-OS 2,405,254.

It is known that corresponding methanediphosphonic acid derivatives are absorbed to only a small extent following oral administration, especially if food is given at the same time.
In order to achieve the desired therapeutic effect, correspondingly higher doses must be administered.

Because of the importance of this class of substances in the treatment of, for example, osteoporosis, Paget's disease, Bechterew's disease and the formation of bone metastases, many attempts are being made to provide a pharmaceutical form of administration from which the active ingredients can readily be absorbed irrespective of whether food is given.

The methanediphosphonic acid derivatives used in accordance with the invention,-which contain two dissociable acid groups and a basic centre, are known to exist in ionic form.
F.N. Marzulli et al., The Journal of ~vestigative Dermatology 44, 339-344 (1965), studied the penetration of radioactively labelled organic phosphoric acid esters and phosphoric acid in vitro through human Stratum corneum and found that ionised phosphoric acid is able to pass through the skin to only an extraordinarily small extent. The conclusion drawn from these studies was that neutral molecules pass through the barrier of the Stratum corneum relatively easily, while ionic forms are able to penetrate only to a very small extent and with great dif~lculty. This view is shared by R.J. Scheuplein, Physiological Reviews 51, 16-23 (1971), who concludes that ionisation drastically reduces skin permeation.

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Even more surprising is the discovery that pharmaceutically acceptable methanediphosphonic acid derivatives, especially those of formula I below, are readily conveyed through the skin and can thus immediately act systemically. These unexpected discoveries were made duling in vitro studies to determine percutaneous absorption properties by the method of A.S. Bhatti et ah, J. Pharm. Pharmacol., 40, 45 P (1988). In these studies, corresponding diffusion cells having a cell surface area of 1.27 cm2 and pig skin as the membrane were used as a model for human skin. The studies showed that sig-nificant therapeutic amounts of active ingredient diffused through the membrane. These results were confirmed in studies of the in vivo transdermal absorption of bisphos-phonates. Experiments were carried out on guinea pigs using 14C-labelled~active ingredient. 6 mg of cold bisphosphonate active ingredient and approximately 106 dpm of 14C-labelled bisphosphonate in 200 ~,11 of 2 % Klucel in distilled water having a pH of 7.5 were applied to a shaved area of 3 x 5 cm, and the area was covered with an occlusive dressing. The radioactive material in the excreted urine was measured after 1, 2 and 3 days.

The present invention relates to topically administrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives or salts thereof, to their rnanufacture and use:

Suitable methanediphosphonic acid derivatives having pharmaceutical activity are, for example, compounds of formula lpo3H2 R1--C--R2 (I) and their salts, wherein each of R1 and R2 is halogen, or wherein R1 is hydrogen and R2 is Ar-S- or Het1-NH-, in which Ar is unsubstituted or substituted phenyl and Het1 is unsubstituted or substituted, monocyclic, 5- or 6-membered monoaza-, diaza- or thiaza-aryl that is bonded vla a ring carbon atom, or wherein R1 is hydrogen or hydroxy and R2 is -A-R3, in which A is aLIcylene and, on the one hand, R3 is Het2, which is Hetl bonded via a ring carbon or ring nitrogen atom, or, on the other hand, R3 is hydrogen, or amino that is unsubstituted or mono- or di-substituted by identical or different substituents selected from alkyl, cycloalkyl, Ar-alkyl, Ar-O-alkyl, Ar-S-alkyl and Hetl-alkyl, or that is 2 ~ 7 disubstituted by optionally Ar-containing alkylene, wherein two alkylene carbon atoms may additionally be linked to one another via alkylene and Ar and Het1 are each as defined above, with the proviso that when R2 is -A-R3, A is ethylene and R3 is un-substituted or C1-C3alkyl-substituted amino, R1 is other than hydroxy.

Salts of compounds of formula I are especially their salts with bases, such as metal salts derived from ~roups Ia, Ib, IIa and IIb of the Periodic Table of Elements, for example alkali metal salts, especially sodium or potassium salts, alkaline earth metal salts, especially calcium or magnesium salts, and also ammonium salts with ammonia or organic amines.

Substituted phenyl is mono- or poly-substituted, for example di- or tri-substituted, for example by lower alkyl, lower alkoxy, trifluoromethyl and/or, especially, by halogen.

Monocyclic, 5- or 6-membered monoaza-, diaza- or thiaza-aryl is, for example, pyrrolyl, imidazolyl, such as 1-, 2- or 4-imidazolyl, pyrazolyl, such as 1- or 3-pyrazolyl, thiazolyl, such as 2- or ~-thiazolyl, or pyridyl, such as 2-, 3- or 4-pyridyl. Corresponding radicals may be mono- or poly-substituted, for example di- or tri-substituted, for example by alkyl.
Preferred substituted radicals are, -for example, imidazol-1-yl and imidazol-5-yl, S-lower alkylthiazol-2-yl, such as 5-methylthiazol-2-yl, 5-ethylthiazol-2-yl and 5-n-butylthia-zol-2-yl, and 2- and 3-pyridyl.

Alkyl is especially lower aLcyl and alkylene is especially lower alkylene, while Ar-alkyl is, for example, phenyl-lower alkyl which is unsubstituted or substituted in the phenyl moiety as indicated above.

Cycloalkyl is especially C3-C7-cycloalkyl, for example, cyclopropyl, cyclobutyl,cyclopentyl, cyclohexyl or cycloheptyl.

Amino that is mono- or di-substituted by alkyl, cycloalkyl, Ar-alkyl, Ar-O-alkyl, Ar-S-alkyl or by Het1-alkyl is especially lower alkylamino, C3-C7-cycloalkylamino, phenyl-lower alkylamino, di-lower alkylamino, lower alkylphenyl-lower alkylamino, diphenyl-lower alkylamino, phenoxy-lower alkylamino, lower alkylphenoxy-lower alkyl-amino, phenoxy-lower alkylphenyl-lower alkylamino, diphenoxy-lower alkylamino, phenylthio-lower alkylamino, lower alkylphenylthio-lower alkylamino, phenylthio-lower alkylphenyl-lower alkylamino, diphenylthio-lower alkylamino, lower alkylpyridyl-lower ~2~

alkylamino, phenyl-lower alkylpyridyl-lower alkylamino, phenoxy-lower alkylpyridyl-lower alkylamino, phenylthio-lower alkylpyridyl-lower alkylamino ordipyridyl-lower alkylamino, the phenyl or pyridyl moiety being unsubstituted or substituted as indicated above.

Amino that is disubstituted by optionally Ar-containing alkylene, for example 1,4-butylene or 1,5-pentylene, is especially lower alkyleneamino or lower alkyleneamino containing a phenyl radical that is unsubstituted or substituted as indicated above, such as pyrrolidin-1-yl, 2-(4-chlorophenyl)-1,4-butyleneamino or 3-phenyl-1,5-pentylenearnino.

Amino that is disubstituted by alkylene wherein two alkylene carbon atoms are additionally linked to one another via alkylene is especially lower alkyleneamino wherein two lower alkylene carbon atoms, especially non-adjacent atoms, are linked to one another via lower alkylene, especially methylene. Preferred are, for example, corresponding 3-azabicyclo-C6-C1oalk-3-yl radicals.

The general definitions used hereinbefore and hereinafter, unless defined otherwise, have especially the following meanings, radicals or compounds designated "lower" containing especially up to and including 7 carbon atoms:

Halogen is especially halogen having an atomic number of up to and including 35, such as fluorine or bromine and also iodine, especially chlorine.

Lower alkyl is, for example, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec.- and tert.-butyl, and also includes corresponding pentyl, hexyl and heptyl radicals. C1-C4alkyl is preferred.

Lower alkoxy is, for example, methoxy, ethoxy, n-propoxy, isopropoxy and n-butoxy, and also includes corresponding pentyloxy, hexyloxy and heptyloxy radicals. Cl-C4alkoxy is preferred.

Lower alkylene is straight-chain or branched and is, for example, C1-Cjalkylene, such as methylene, ethylene, propylene, butylene, pentylene and hexylene and heptylene, and also 2-methyl-1,3-propylene and 2,4- or 1,5-dimethyl-1,5-pentylene. Lower alkylene as a substituent of disubstituted amino R3 contains at least two carbon atoms, preferably from 4 to 6 carbon atoms. In amino that is disubstituted by lower alkylene, lower alkylene linking two lower alkylene carbon atoms contains especially up to and including S carbon atoms and is preferably methylene.

The compounds of formula I and their salts are known, or they can be prepared in a manner known per se.

For example, compounds of formula I wherein E;~l is hydrogen and R2 is Ar-S- areobtainable by reaction of tetra-lower alkylmethane-diphosphonate with a disulfide of the formula Ar-S-S-Ar in the presence of a slrong metal base, such as NaH, and subsequent acid hydrolysis of the tetra-lower alkyl ester (see, for example, EP 100,718).

Corresponding compounds of formula I wherein Rl is hydrogen and R2 is Hetl-NH- can be prepared, for example, by reacting a mixture of H3PO3 and PHal3, wherein Hal is halogen, especially chlorine, with a formylamine of the formula Hetl-NH-CHO or heating an amine Hetl-NH2 with an orthoformic acid lower alkyl ester and a di-lower alkyl phosphite, and hydrolysing the reaction product, for example in the presence of an acid (see7 for example, EP 274,346).

For the preparation of compounds of formula I wherein Rl is hydrogen and R2 is -A-R3 and A is alkylene, it is possible, for example, to use cornpounds of the formula R3-A-Hal as starting materials and to Ieact those compounds with a tetra-lower alkylmethane-diphosphonate in the presence of a strong base, for example NaH, and to hydrolyse the resulting tetra-lower alkyl ester of corresponding compounds of formula I, for example in the presence of an acid, such as hydrochloric acid (see, for example, EP
275,821).

Compounds of formula I wherein Rl is hydroxy and R2 is -A-R3 can be prepared, for example, by reacting a carboxylic acid of the formula R2-COOH with a phosphorylating agent, such as a mixture of H3PO3 and PHal3, and working up under hydrolytic conditions (see, for example, EP 170,228 and EP 252,505).

The methanediphosphonic acid derivatives of formula I have valuable pharmacological properties. In particular, they have a pronounced regulatory effect on the calcium metabolism of warm-blooded animals. They also bring about a marked inhibition of bone resorption in rats, which can be demonstrated both in the test arrangement according to Acta Endocrinol. 78, 613-24 (1975) and in the TPTX (thyroparathyroidectomised) rat 2~2~7 model by means of experimental hypercalcaemia induced by vitamin D3. Likewise, tumour hypercalcaemia induced by Walker-256 tumours is inhibited following peroral administration. Furthermore, in adjuvant arthritis in rats they exhibit a pronounced inhibition of the progress of chronic-arthritic processes in the test arrangement according to Newbould, Brit. J. Pharrnacology 21, 127 (1963) and according to Kaibara et al., J. Exp.
Med. 159, 1388-96 (1984). They are therefore excellently suitable as active ingredients in medicaments for the treatment of diseases that can be associated with disorders of the calcium metabolism, for example inflammatory processes in joints and degenerative processes in articular cartilage, and osteoporosis, periodontitis, hypeIparathyroidism and calcium deposits in blood vessels or on prosthetic implants. They have a favourable effect both on diseases in which abnormal deposition of difficultly soluble calcium salts is observed, such as diseases of the arthritis type, for example Bechterew's disease, neuritis, bursitis, periodontitis and tendinitis, fibrodysplasia, osteoarthritis or arteriosclerosis, and on diseases involving abnormal degeneration of hard body tissue, such as hereditary hypophosphatasia, degenerative processes in articular cartilage, osteoporoses of various origins, Paget's disease and Osteodystrophia fibrosa, as well as osteolytic processes caused by tumours, and hypercalcaemia. Individual examples of the above-defined class of substances are already being used therapeutically.

The invention relates especially to topically administrable pharmaceutical preparations that contain a pharmaceutically effective methanediphosphonic acid of formula I or a salt thereof, wherein each of R1 and R2 is halogen, or wherein R1 is hydrogen and R2 is Ar-S-or Hetl-NH-, in which Ar is unsubstituted or substituted phenyl and Het1 is unsubstituted or substituted, monocyclic, 5- or 6-membered monoaza-, diaza- or thiaza-aryl that is bonded via a ring carbon atom, or wherein R1 is hydrogen or hydroxy and R2 is -A-R3, in which A is alkylene and, on the one hand, R3 is Het2, which is ~etl bonded via a ring carbon or ring nitrogen atom, or, on the other hand, R3 is hydrogen, or a~nino that is unsubstituted or mono- or di-substituted by identical or different substituents selected from alkyl, Ar-alkyl, Ar-O-alkyl and Het1-alkyl, or that is di-substituted by optionally Ar-containing alkylene, wherein two alkylene carbon atoms may additionally be linked to one another via alkylene and Ar and Het1 are each as defined above, with the proviso that when ~2 is -A-R3, A is ethylene and R3 is unsubstituted or C1-C3alkyl` substituted amino, R1 is other than hydroxy.

The invention relates especially to topically administrable pharmaceutical preparations that contain a pharmaceutically effective methanediphosphonic acid of formula I or a salt -7- ~2~7 thereof, wherein each of Ri and R2 is halogen, or wherein Rl is hydrogen and R2 is Ar-S-or Hetl-NH-, in which Ar is phenyl that is unsubstituted or substituted by lower alkyl, lower alkoxy, trifluoromethyl andlor, especially, by halogen, and Hetl is unsubstituted or lower alkyl-substituted thiazolyl, or wherein Rl is hydrogen or hydroxy and R2 is -A-R3, in which A is lower alkylene and, on the one hand, R3 is unsubstituted or lower alkyl-substituted imidazolyl that is bonded via a ring carbon or ring nitrogen atom, or is pyridyl, or, on the other hand, R3 is hydrogen, or amino that is unsubstituted or mono- or di-substituted by identical or different substituents selected from lower aLt~yl, C3-C7-cycloalkyl, Ar-lower alkyl, Ar-O-lower alkyl, Ar-~-lower alkyl and pyridyl-lower alkyl, or that is disubstituted by optionally Ar-containing lower alkylene or-by lower alkylene wherein two non-adjacent lower alkylene carbon atoms are additionally linked to one another via lower alkylene, and Ar in each case is as defined above, with the proviso that when R2 is -A-R3, A is ethylene and R3 is unsubstituted or Cl-C3alkyl-substituted amino, Rl is other than hydroxy.

The invention relates preferably to topically administrable pharmaceutical preparations that contain a pharrnaceutically effective methanediphosphonic acid of formula I or a salt, especially an alkali metal salt, for example sodium salt, thereof, wherein each of Rl and R2 is halogen, especially chlorine, or wherein Rl is hydrogen and R2 is phenylthio that is unsubstituted or substituted by halogen, such as chlorine, for example 4-chlorophenylthio, or thia~olylamino that is unsubstituted or substituted by lower alkyl, especially Cl-C4alkyl, such as methyl, for example thiazol-2-yl-, 5-n-butylthiazol-2-yl-, 5-ethylthiazol-2-yl- or 5-methylthiazol-2-yl-amino, or wherein Rl is hydrogen or hydroxy and R2 is -A-R3 in which A is Cl-C7alkylene, such as methylene, ethylene, propylene or pentylene, and R3 is imidazolyl that is bonded via a ring carbon or ring nitrogen atom and is unsubstituted or substituted by lower alkyl, especially Cl-C4alkyl, such as methyl, for example imidazol- l-yl, imidazol-5-yl, 1-methylimidazol-2-yl or 4-methylimidazol-5-yl, or is pyridyl, such as 2- or 3-pyridyl, or wherein Rl is hydroxy and R2 is -A-R3 in which A
is as defined above and R3 is amino, di-Cl-Csalkylamino, such as dimethylamino, N-methyl-M-n-propylamino or N-methyl-N-n-pentylamino, N-C3-C7-cycloalkylamino, such as cycloheptylamino, N-Cl-C4alkyl-N-phenyl-Cl-Csalkylamino, such as N-methyl-N-(2-phenylethyl)-amino, N-methyl-N-(3-phenylpropyl)-amino or N-methyl-N-(5-phenylpentyl)-amino, N-Cl-C4alkyl-N-phenoxy-Cl-C4alkylamino, such as N-methyl-N-(3-phenoxypropyl)-amino, N-Cl-C4alkyl-N-phenylthio-Cl-C4alkylamino, such as N-methyl-N-(2-phenylthioethyl)-amino, N-Cl-C4alkyl-N-pyridyl-Cl-C4alkyl-amino, such as N-methyl-N-[3-(2-pyridyl)-propyl]-amino, C~-C6allcyleneamino that is 2~2~7 unsubstituted or substituted by phenyl which may contain halogen, such as chlorine, such as 4-chlorophenyl, for exa~nple piperidin-l-yl that is unsubstituted or substituted, especially in the 4-position, by phenyl, or pyrrolidin- 1 -yl that is unsubstituted or substi-tuted, especially in the 3-position, by 4-chlorophenyl, or 1,S-di-C1-C4alkyl-, such as 1 ,S-dimethyl-3-azabicyclo[3. 1. l]hept-3-yl, or wherein Rl is hydroxy and R2 is -A-R3 in which A is C1-C4alkylene, especially methylene, and R3 is hydrogen, with the proviso that when R2 is -A-R3, A is ethylene and R3 is unsubstituted or C1-C3alkyl-substituted amino, R1 is other than hydroxy.

The invention relates especially to topically administrable pharmaceutical preparations that contain a pharmaceutically effective methanediphosphonic acid of formula I or a salt, especially an alkali metal salt, for example sodium salt, thereof, wherein R1 is hydroxy and R2 is -A-R3, in which A is C2-qalkylene, such as ethylene, propylene or pentylene, and R3 is amino, di-C1-C4alkylamino, such as dimethyl- or N-methyl-N-n-propyl-amino, N-C3-C7-cycloalkylamino, such as cycloheptylamino, N-C1-C4alkyl-N-phenyl-C1-C4-alkylamino, such as N-methyl-N-(3-phenylpropyl)-amino, N-C1-C4alkyl-N-phenoxy-C1-C4alkylamino, such as N-methyl-N-(3-phenoxypropyl)-amino, or N-C1-C4alkyl-N-phenylthio-C1-C4alkylamino, such as N-methyl-N-(2-phenylthioethyl)-amino, with the proviso that when R2 is -A-R3, A is ethylene and R3 is unsubstituted or C1-C3alkyl-substituted amino, R1 Is other than hydroxy.

The invention relates especially to topically administrable pharrnaceutical preparations that contain a pharl-naceutically effective methanediphosphonic acid of formula I or a salt, especially an alkali metal salt, for example sodium salt, thereof, wherein R1 is hydroxy and R2 is -A-R3, in which A is Cl-C7alkylene, especially C1-C4alkylene, such as methylene, and R3 is imidazolyl that is bonded via a ring carbon or ring nitrogen atom and is unsubstituted or substituted by C1-C4alkyl, such as methyl, such as especially imidazol-1-yl and also irnidazol-5-yl, 1-methylimidazol-2-yl or 4-methylimidazol-S-yl.

The invention relates especially to topically administrable pharmaceutical preparations that contain a pharmaceutically effective methanediphosphonic acid selècted from the following compounds of folmula I:

4-amino-1-hydroxybutane-1,1-diphosphonic acid, 6-amino-1-hydroxyhexane-1,1-diphos-phonic acid, 3 - (N-methyl-N-n-pentylamino)- 1 -hydroxypropane- 1,1 -diphosphonic acid, 2~2~7 3-[N-(3-phenylpropyl)-N-methylamino]-1-hydroxypropane-1,1-diphosphonic acid, 3-(N-methyl-N-S-phenylpentylamino)-1-hydroxypropane-1,1-diphosphonic acid, 3-[N-methyl-N-3-(2-pyridyl)-propylamino]-1-hydroxypropane 1,1-diphosphonic acid, 1-hydroxy-3-[N-methyl-N-(3-phenoxypropyl)-amino~-propane-1,1-diphosphonic acid, 1-hydroxy-3-[N-methyl-N-(2-phenoxyethyl)-amino]-propane~ diphosphonic acid, 4-(4-phenyl-piperidin- 1 yl)- 1 -hydroxybutane- 1,1 -diphosphonic acid, 1-hydroxy-3-(1-piperidino)-propane-1,1-diphosphonic acid, 1-hydroxy-3-[3-(4-chlorophenyl)-pyrrolidin-1-yl]-propane-1,1-diphosphonic acid, 1-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosphonic acid, 2-(1-methylimidazol-2-yl)-ethane- 1,1 -diphosphonic acid, 1 -hydroxy-2-(4-methylimidazol-5-yl)-ethane- 1,1 -di-phosphonic acid, 1-hydroxy-2-(imidazol-5-yl)-ethane-1,1-diphosphonic acid, 1-hydroxy-2-(3-pyridyl)-ethane-1,1-diphosphonic acid, 2-(2-pyridyl)-ethane-1,1-diphosphonic acid, 1-[(5-n-butyl-2-thiazolyl)-amino]-methane-1,1-diphosphonic acid, 1-[(5-methyl-2-thia-zolyl)-amino]-methane-1,1-diphosphonic acid, 1-[(2-thiazolyl)-amino]-methane-1,1-di-phosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, 1-(4-chlorophenylthio)-methane-1,1-diphosphonic acid, 1,1-dichloromethane-1,1-diphosphonic acid or 3-(1,5-di-methyl-3-azabicyclo[3. 1.1 ]hept-3-yl)- 1 -hydroxypropane- 1,1 -diphosphonic acid, and also 1-[(5-ethyl-2-thia~olyl)-amino]-methane-1,1-diphosphonic acid, 3-[N-(2-phenylethyl)-N-methylamino]-1-hydroxypropane-l,1-diphosphonic acid, 3-[N-(2-phenylthioethyl)-N-methylamino]- 1 -hydroxypropane- 1,1 -diphosphonic acid, 1-hydroxy-3-(pyrrolidin-1-yl)-propane-l,1-diphosphonic acid or 2-(N-cycloheptylamino)-ethane-1,1-diphosphonic acid, or a pharmaceutically acceptable salt thereof.

The invention relates also to a process for the manufacture of the topically administrable pharmaceuùcal preparations according to the invention, which process may be ca~;ried out in accordance with methods known ~ se and comprises processing a pharmaceutically acceptable methane diphosphonate derivative with customary pharmaceutically acceptable adjuncts and additives.

The invention relates further to a method of increasing the absorption of pharmaceutically acceptable methanediphosphonic acid derivatives, especially of compoùnds of formula I, which comprises incorporating a compound of fo~mula I or a salt thereof into a pharmaceutical composition for topical administration.

The invention relates specifically to the pharmaceutical preparations described in the 2~

Examples and to processes for the manu-facture thereof.

Depending on the starting materials and procedures chosen, the compounds of formula I
may be in the form of one of the possible isomers or in the form of a mixture thereof, for example in the form of optical isomers, such as enantiomers or diastereoisomers, or geometrical isomers, such as cis-trans isomers. The optical isomers are in the form of the pure antipodes and/or of racemates.

The compounds of formula I may also be employed in the form of their hydrates orinclude other solvents used for crystallisation.

The topically administrable pharmaceutical preparations according to the invention contain the pharmaceutically acceptable compounds of formula I, for example, in a pharrnacologically effective amount, together with a pharmaceutically acceptable additive or adjunct. The daily dose of active ingredient depends on age and individual condition and on the method of administration.

Pharmaceutical preparations suitable for topical administration are especially creams, ointments and gels and also pastes, foams, tinctures and solutions that contain from approximately 0.5 to approximately ~ % active ingredient.

Creams or lotions are oil-in-water emulsions that contain more than 50 % water. As oily base there are used especially fatty alcohols, especially those containing from 12 to 18 carbon atoms, for example lauryl, cetyl or stearyl alcohol, fatty acids, especially those containing from lO to 18 carbon atoms, for example palmitic or stearic acid, liquid to solid waxes, for example isopropyl myristate, wool wax or beeswax, and/or hydrocarbons, especially liquid, semi-solid or solid substances or mixtures thereof, for example petroleum jelly (petrolatum) or paraffin oil. Suitable emulsifiers are surface-active substances having predominantly hydrophilic properties, such as corresponding non-ionic emulsifiers, for example fatty acid esters of polyalcohols or ethylene oxide adducts thereof, especially corresponding fatty acid esters with (poly)ethylene glycol, (poly)propylene glycol or sorbitol, the fatty acid moiety containing especially from 10 to 18 carbon atoms, especially partial glycerol faKy acid esters or partial fatty acid esters of polyhydroxyethylene sorbitan, such as polyglycerol fatty acid esters or polyoxyethylene sorbitan fatty acid esters (Tweens), and also polyoxyethylene fatty alcohol ethers or fatty acid esters, the fatty alcohol moiety containing especially from 12 to 18 carbon atoms and ~2~7 the fatty acid moiety especially from 10 to 18 carbon atoms, especially those having approximately from 2 to 23 ethylene glycol or ethylene oxide units, such as poly-hydroxyethylenecetylstearyl ether (for example Cetomacrogol), polyhydroxyethylene-(4)-lauryl ether and polyhydroxyethyleneglycerol fatty acid ester (for example Tagat S), or corresponding ionic emulsifiers, such as alkali metal salts of fatty alcohol sulfates, especially having from 12 to 18 carbon atoms in the fatty alcohol moiety, for example sodium lauryl sulfate, sodium cetyl sulfate or sodium stearyl sulfate, which are usually used in the presence of fatty alcohols, for example cetyl alcohol or stearyl alcohol. Additives to the aqueous phase are, inter alia, agents that prevent the creams from drying out, for example humectants, such as polyalcohols, such as glycerol, sorbitol, propylene glycol and/or polyethylene glycols, and also preservatives, perfumes, etc..

Ointments or lotions are water-in-oil emulsions that contain up to 70 %, but preferably from approximately 20 % to approximately 50 %, water or aqueous phase. Suitable as fatty phase are especially hydrocarbons, for example petroleum jelly, paraffin oil and/or hard paraffins, which, in order to improve the water-binding capacity, preferably contain suitable hydroxy compounds, such as fatty alcohols or esters thereof, for example cetyl alcohol or wool wax alcohols, or wool wax. Emulsirlers are corresponding lipophilic substances, for example of the type indicated above, such as sorbitan fatty acid esters (Spans), for example sorbitan oleate and/or sorbitan isostearate. Additives to the aqueous phase are, inter alia, humectants, such as polyalcohols, for example glycerol, propylene glycol, sorbitol and/or polyethylene glycol, and also preservatives, perfumes, etc..

Microemulsions are isotropic systems based on the following four components: water, an emulsifier, for example of the type indicated above, such as a surfactant, for example emulgin, a lipid, such as a non-polar oil, for example paraffin oil, and an alcohol containing a lipophilic group, for example 2-octyldodecanol. If desired, other additives may be added to the microemulsions.

Fatty ointments are water-free and contain as base especially hydrocarbons, for example paraffin, petroleum jelly and/or liquid paraffins, also natural or partially` synthetic fat, such as fatty acid esters of glycerol, for example coconut fatty acid triglyceride, or preferably hardened oils, for example hydrogenated groundnut oil or castor oil, also fatty acid partial esters of glycerol, for example glycerol mono- and di-stearate, and also, for example, the fatty alcohols increasing the water-absorption capacity, emulsifiers and/or additives mentioned in connection with the ointments.

With gels, a distinction is made between aqueous gels, water-free gels and gels having a low water content, which gels consist of swellable, gel-forming materials. There are used especially transparent hydrogels based on inorganic or organic macromolecules. High molecular weight inorganic components having gel-forming properties are pledominantly water-containing silicates, such as aluminium silicates, for example bentonite, magnesium aluminium silicates, for example Veegum, or colloidal silicic acid, for example Aerosil.
As high molecular weight organic substances there are used, for example, natural, semi-synthetic or synthetic macromolecules. Natural and semi-synthetic polymers are derived, for example, *om polysaccharides containing a great variety of carbohydrate components, such as celluloses, starches, tragacanth, gum arabic and agar-agar, and gelatin, alginic acid and salts thereof, for example sodium alginate, and derivatives thereof, such as lower alkylcelluloses, for example methyl- or ethyl-cellulose, carboxy- or hydroxy-lower alkylcelluloses, for example carboxymethyl- or hydroxyethyl-cellulose. The components of synthetic gel-forming macromolecules are, for example, suitably substituted unsaturated aliphatic compounds such as vinyl alcohol, vinylpyrrolidine, acrylic or meth-acrylic acid. Examples of such polymers are polyvinyl alcohol derivatives, such as polyviol, polyvinylpyrrolidines, such as collidone, polyacrylates and polymethacrylates, especially having a molecular weight of from approximately 80000 to approximately 1 million, or salts thereof, such as Rohagit S, Eudispert or Carbopol. Customary additives, such as preservatives or perfumes, may be added to the gels.

Foams are administered, for example, from pressurised containers and are liquid oil-in-water emulsions in aerosol forrn; unsubstituted or halogenated hydrocarbons, such as alkanes, for exarnple propane or butane, or chlorofluoro-lower alkanes, for example dichlorodifluoromethane and dichlorotetrafluoroethane, are used as propellant. As oil phase there are used, inter alia, hydrocarbons, for example paraffin oil, fatty alcohols, for example cetyl alcohol, fatty acid esters, for example isopropyl myristate, and/or other waxes. As emulsifiers there are used, inter alia, mixtures of emulsifiers havingpredominantly hydrophilic properties, such as polyoxyethylene sorbitan fatty acid esters (Tweens), and ernulsifiers having predominantly lipophilic properties, sùch as sorbitan fatty acid esters (Spans). The customary additives, such as preservatives, etc., are also added.

Tinctures and solutions generally have an ethanolic base, to which water may be added and to which there are added, inter alia, polyalcohols, for example glycerol, glycols and/or polyethylene glycol, as humectants for reducing evaporation, and fat-restoring substances, such as fatty acid esters with low molecular weight polyethylene glycols, that is to say lipophilic substances that are soluble in the aqueous mixture, as a replacement for the fatty substances removed from the skin by the ethanol, and, if necessary, other adjuncts and additives. Suitable tinctures or solutions may also be applied in spray form by means of suitable devices.

The manufacture of the topically administrable pharmaceutical preparations is ef-fected in a manner known ~ se, for example by dissolving or suspending the active ingredient in the base or, if necessary, in a portion thereof~ When the active ingredient is administered in the form of a solution, it is generally dissolved in one of the two phases before emulsification; when the active ingredient is administered in the form of a suspension, it is mixed with a portion of the base after emulsification and then added to the remainder of the formulation.

The present invention relates especially to multi-layered therapeutic systems for the transdermal administration of pharmaceutically acceptable methanediphosphonic acid derivatives, especially those of formula I, and their salts, which contain essentially the following constituents:

(1) a closed backing foil which is impermeable to the subsequent layers of the consti-tuents of the active ingredient forrnulation, (2) a reservoir for the active ingredient, next to the backing foil, provided that the active ingredient is not already present in the adhesive foil, (3) an adhesive layer and (~) a peel-off protecùng foil~

The therapeutic system according to the invention for the transdermal administraùon of methanediphosphonic acid derivatives of formula I is preferably in the form of a plaster having a base surface that is at least as large in area as the area of the skin envisaged for the administration and at least as large as is require~ for it to stay firmly in place over the entire period of treatment~ The base surface must be large enough for sufficient quantities of the active constituents of the active ing;edient formulation ~For example, active ingredient and the agents for enhancing percutaneous absorption, hereinafter "penetration enhancers") to be absorbed by the skin. Although, in theory, very large areas of skin are available for taking the plaster, for reasons of comfort the wanted surface area of the base surface of the plaster is about 200 cm2, in the first line about 20 to about 30 cm2.

The plaster may be of any geometrical shape, e.g. may be oval, elliptical, circular, rectangular, optionally with rounded corners, oblong or rectangular with one or two rounded tabs. Other shapes are also possible.

The backing foil (1) consists of a material or of a combination of materials that must be impermeable to the constituents of the formulation contained in the reservoir (2). It serves as a protecting and car~ier layer. To produce the backing foil, it is possible to use high or low pressure polymers such as polyethylene, polypropylene, polyvinyl chloride, polyurethane, polyethylene terephthalate or also cellulose acetate or vinyl acetate/vinyl chloride copolymers and combinations, especially composite -foils thereof. An imper-meable, flexible backing foil that conforms to the shape of the part of the body to which the plaster is applied and that consists of materials suitable for the manufacture of hot form-sealed systems is preferred.

The reservoir (2~ for the active ingredient is situated between the backing foil (1) and the adhesive layer (3), which in turn is arranged on the peel-off protecting foil (4), and contains all essential constituents of the active ingredient formulation. The reservoir serves to hold the active ingredient in a limited space for relase to the skin. It may contain a liquid, semi-solid or solid active ingredient formulation or may formed as homogeneous or inhomogeneous polymer matrix containing itself the active ingredients. Preferably, the reservoir layer containing the active ingredient is formed as adhesive matrix which in case of a monolith system needs no additional adhesive layer. In an other preferred embodiment as reservoir a liquid or semi-solid composition which contains the active ingredient and which may melt a skin temperature is embedded in a non-woven fabric or in a polymeric foam.

However, if the reservoir is not itself the adhesive matrix or is incorporated in an adhesive Iayer, it can be bonded to an adhesive layer, which in turn can be bonded to the peel-off layer. Furthermore, a porous or perrneable membrane may be arranged between the reservoir and an adhesive layer which in tum is arranged on a peel-off layer (4).

2 q32~eri~i ~

For example, an arrangement in which the reservoir is in firm contact with the skin is known per se and is described, for example, in British Patent Application 2,021,950. The area of the backing foil (1) is greater than the area occupied by the reservoir (2) and, therefore, the backing foil projects beyond the reservoir, the projecting portion of the backing foil ( l) being provided with an adhesive layer and adheIing to the skin. The peel-off protecting foil (4) lies over the adhesive layer (3) and over the reservoir (2), it being possible for the latter also to be limited by an additional membrane.

An example of a system in which the reservoir (2) is, for example, in firm contact wi~h the adhesive layer (3), it being possible for the active ingredient base to be present both in the reservoir and in the adhesive layer, is described in U.S. Patent Specification 4,597,961.
The backing foil (1) is also larger in area than the area occupied by the reservoir (2) and projects beyond the latter. The adhesive layer (3) covers both the reservoir (2) and the projecting portion of the backing foil (1). The peel-off protecting foil (4) lies on top of the adhesive layer.

The matrix used for immobilising drug compositions which are liquid or semi-solid or which melt at skin temperature essentially consists of, for example, natural or synthetic polymers, such as cotton, cellulose, regenerated cellulose, polyamides, polyester, polyurethane or cellulose derivatives, for example those of the type described below, viscose or polypropylene. In particular, such fibrous structures are used in the form of a non-woven fabric or in form of woven and mitted fabrics and also foams.

The reservoir (2) can also contain liquid polymeric material in which the active in~redient formulation or constituents thereof are homogeneously dispersed. Such polymeric materials are, for example, silicone rubber (silicones), e.g. linear organosiloxanes in which every silicon atom in the siloxane chain is substituted by two identical or different aLkyl, e.g. methyl or ethyl, aryl, e.g. phenyl, alkenyl, e.g. vinyl or allyl, aL~cylaryl, e.g. tolyl or xylyl, or aralkyl, e.g. benzyl, radicals, and every terminal silicon atom is substituted by three of the mentioned organic radicals. The preparation of these silicones is described in U.S. Patent Specifications 2,541,137, 2,723,966, 2,863,846, 2,890,188, 2,927,907, 3,002,951 and 3,035,016.

In addition to the liquid polymeric material and the active ingredient formulation, the reservoir (2) can also contain other liquids such as glycerol or propylene glycol and also 2~2~7 water and have the release properties described in U.S. Patent Specification 4,291,015.

The contents of the reservoir (2) preferably consist exclusively of the actual active ingredient formulation which contains the penetration enhancer, especially ethanol, the active ingredient and, optionally, other auxiliaries, for example gelling agents and, optionally, viscosity-increasing adjuncts, such as polyvinyl alcohol, polyvinylpyrrolidone, cellulose derivatives, e.g. those of the type mentioned, and gelatin.

The reservoir (2) can, in addition, be provided with a permeable layer of the required permeability to the active ingredient and the penetration enhancer. This layer controls the rate of release of the penetration enhancer and/or of the active ingredient from the system to the skin and is also called a control or regulating membrane.

The materials that can be used in the therapeutic systems of the invention for producing the permeable layer are known 1~ se. Such membrane materials may be homogeneous (diffusion membranes) or macrostructured (porous membranes). The latter may be regarded as being a sponge-like structure having a skeleton of polymeric material with interconnected voids and pores dispersed therein. Membrane materials that control the rate of release may consist of isotropic material with a homogeneous structure or of anisotropic material with a non-homogeneous structure. Such materials are commercially available and can be produced in various ways, for example as described by R.E. Kesting, Synihetic Polymer Membranes, McGraw Hill, Chapters 4 and 5, lg71, J.D. Ferry, Ultra-filtration Membranes, Chemical Review, Vol. 18, page 373, 1984.

Membrane materials having from 5 to 95 % by volume voids and an effective pore diameter of approximately from 1.0 x 10-9 m to 1.0 x 10-4 m are especially suitable.
More especially suitable are membrane materials having pore diameters of less than approximately 5.0 x 10-9 m and molecular diffusion. For best results, reference should be made to the prior art and the known embodiments with known membrane materials and known shapes which ensure an optimum rate of release of the active ingredient. In particular, the membrane material must be chemically resistant to the active ingredient and to the penetration enhancer used.

A list of suitable membrane materials, which should not be regarded as exhaustive, is given below:

2~2~7 polycarbonates, e.g. linear polyesters of carbonic acid derivatives that containcarbonate groups in the polymer chain and can be p}epared, for example, by reacting dihydroxy aromatic compounds with phosgene. Such materials are obtainable from General Elect;ic under the trade mark Lexan(~;

polyvinyl chlorides, e.g. PVC, which is obtainable from Goodrich under the trade mark Geon(~) 121;

polyamides of the polyhexamethyleneadipamide type, or polyamides known by the generic name "Nylon". An especially suitable material is sold under the trade mark Nomex(~ by DuPont;

acrylic acid copolymers, e.g. those which are sold under the trade name Dynel~ and consist of about 60 % polyvinyl chloride and 40 % acrylonihile, and styrene/acrylic acid copolymers and the like;

polysulfones with diphenylsulfone groups in the linear chain. Such polymers are sold as P-1700 by Union Carbide;

halogenated polymers, such as polyvinylidene fluorides, that are sold, for example, under the trade mark Kynar(~' by Pennwalt; polyvinyl fluorides that are obtainable from l:)uPont under the trade mark Tedlar~), and polyfluorohalocarbons obtainable under the trade mark Aclar~) from Allied Chemical;

polychloroethers that are sold by Hercules under the trade mark Penton(3', and other sirnilar thermoplastic polymers;

acetal polymers such as the polyformaldehyde polymers that are sold by DuPont under the trade mark Delrin~, and the like;

acrylic acid resinates, such as polymethyl methacrylate, poly-n-butyl methacrylate and the like;

polyethylene and copolymers of ethylene, e.g. with vinyl acetate or acrylates.

other polymers, such as polyurethanes, polyimides, polybenzimidazoles, polyvinyl ~2~

acetate, aromatic and aliphatic polyethers, cellulose esters, for example cellulose tri-acetate, cellulose, Colledion~ (cellulose nitrate with 11 % nitrogen), epoxy resinates, polyolefins, e.g. polyethylene/polypropylene, porous rubber, polyvinylpolypyrrolidone, crosslinked polyvinyl alcohol, copolymers of vinylpyrrolidone and vinyl alcohols, polyelectrolyte structures consisting of two ionically associated polymers as are described in U.S. Patent Specifications 3,549,016 and 3,546,142, polystyrene derivatives such as polystyrene sodium sulfonates or polyvinylbenzyltrimethylammonium chlorides, polyhydroxyethyl methacrylates, polyisobutyl vinyl ether and similar polymers can also be used. Other copolymers that are obtainable by copolymerisation of various amounts of the monomers forming the basis of the mentioned polymers can also be used to produce the membrane material determining the rate of release of the active ingredient and/or the penetration enhancer.

When using a perrneable membrane, several arrangements are possible: the active ingredient formulation is arranged between the backing foil (1) and the membrane. In that arrangement, the backing foil and the membrane form a space which can optionally be divided into several compartments. In certain embodiments, the backing foil (1) and the membrane are joined, e.g. welded or glued, to each other at the very edge. In these embodiments, the active ingredient and the penetration enhancer are contained in the same reservoir. These embodiments are preferred when the active ingredient formulation is liquid or semi-solid.

It is also possible, in accordance with the embodiment described in German Offenlegungsschrift 3,205,258, to fill the space formed by the backing foil (1) and the membrane only with penetration enhancer, e.g. ethanol, and optionally with a gelling agent or viscosity-increasing adjunct, such as gelatin, and to apply the active ingredient formulation to the other side of the membrane. In that case, the membrane would control only the rate of diffusion of the enhancer. The active ingredient can be present in a separate layer between membrane and adhesive layer (3) and optionally or exclusively in the adhesive layer (3).

The reservoir (2) can, in addition, be divided into several compartments: This division into compartments is suitable for liquid active ingredient formulations and prevents the latter from sinking and becoming concentrated at the lowest point of the system if cavities or folds are formed as a result of the plaster not being stored flat. Division into compartments is especially advantageous if the reservoir layer occupies an area of more ~2`~

than 30 cm2. The compartments can be distributed as desired. For example, a radial arrangement of the partitions, extending from the middle point of the plaster, or vertical or horizontal boundaries, or oblique lines etc. are possible.

Division of the compartments, especially by partitions or seal seams, can be effected by hot-welding. In this procedure, the material of the backing foil (1) is welded to the material of the membrane layer.

Dermatologically acceptable adhesives are suitable for the adhesive layer (3). Suitable adhesives are, for example, silicone adhesives [e.g. of the Bio-PSA~ or Silicon Adhesive 355 (Dow Corning) type], adhesive -formulations of acrylic acid resins or methacIylic acid resins, e.g. polymers of acrylic acid or methacrylic acid esterified by alcohols such as n-butanol, n-pentanol, isopentanol, 2-methylbutanol, 1-methylbutanol, 1-, 2- or 3-methylpentanol, 2-ethylbutanol, isooctanol, n-decanol or n-dodecanol, or copolymers of these acrylic acid or methacrylic acid esters with monomers containing ethylene groups, such as acrylic acid itself, methacrylic acid, acrylamide, methacrylamide, N-alkoxy-methacrylamide, N-alkoxymethylmethacrylamide, N-tert.-butylamide, itaconic acid, vinyl acetate [e.g. of the Durotak(~) 280-2516 type (~ational Starch & Chemical B.V.)], N-branched alkylmaleic acid amide in which the branched alkyl group has from 10 to 24 carbon atoms, glycol diacrylates or mixtures thereof, polyalkenylenes, such as polyisobutylenes of different molecular weights, for example of from approximately 100 to 1.5 million, e.g. polyisobutylene 300 or 35000 or 1.2 million, hydrogenated hydrocarbon resins, natural or synthetic rubber, such as styrenebutadiene, butyl ether, neo-prene, polyisobutylene, polybutadiene and polyisoprene, polyvinyl acetate, urea/formaldehyde resinates, resorcinol/formaldehyde resinates, cellulose derivatives such as ethylcellulose, methylcellulose, nitrocellulose, cellulose acetate butyrate and carboxymethylcellulose, and also natural gums such as agar, acacia, pectin, starch, dextrin, alburnin, gelatin, casein, etc.. Also suitable as adhesives are corresponding silicone adhesives. It is also possible to add thickeners and stabilisers and also solvents to the mentioned adhesives; however, they may be used without solvents in the form of so-called hot-melt adhesives, which are applied at higher temperatures to the polymeric materials in the molten state. The solvents in which the adhesives are dissolved are àre, especially, are readily volatile and tolerated by the skin. Examples that may be mentioned are corresponding hydrocarbons, such as alkanes, e.g. hexane, heptane, aromatic hydrocarbons, e.g. toluene, lower alkanols, such as methanol, ethanol or isopropanol, esters, such as lower alkanecarboxylic acid-lower alkyl esters, e.g. ethyl acetate, or - 20 ~ $ ~

ketones, such as acetyl acetone, or mixtures thereof.

The adhesive layer (3) may be applied to some or all of the membrane. If the membrane is completely covered by the adhesive layer, the latter may, in addition to its actual function as an adhesive to the skin, act as a perrneable membrane. The desired membrane properties, e.g. control of the rate of diffusion of the penetration enhancer, can be obtained by varying the thickness and composition of the adhesive layer (3). The adhesive layer (3) may, in addition, contain the total amount or, preferably, a portion of the active ingredient.
The amount of active ingredient contained in the adhesive layer (3) can be used, in particular, to administer an initial surge dose before the continuous release,-which is controlled by the therapeutic system, commences at the desired therapeutic level.

The membrane can also be covered by the adhesive layer (3) partially and/or discontinuously. A covering at the edges is possible, for example an annular circumferential covering. The membrane can also be covered in a pattern, for example in a rhomboidal pattern. The membrane can be covered at the outer edge by a continuous band of adhesive material, for example in the shape of a ring, and on the inside surface with discontinuous bands, for example in a rhomboidal pattern.

The protecting foil (4) is rernoved before application. It consists of materials that are impermeable to the constituents of the reservoir layer (2). It is possible' to use the same materials as those used for producing the backing foil (1), and also metal foils, for example thin aluminium foil. Organic polymers are rendered capable of being peeled off the adhesive layer, for example, by suitable surface treatment, for example silicone treatment.

The active ingredient formulation contained in the transdermal therapeutic system of the invention, especially in the reservoir (2), contains as adjunct an agent that enhances percutaneous absorption (penetration enhancer - "flux enhancer") which increases the flux of the active ingredients of formula I through the'skin, so that a greater quantity of active ingredients is absorbed by the skin per unit of application area and per unit of time. The penetration enhancer can, in addition, accelerate the flow of the active ingredient through -the permeable membrane layer in membrane systems. In particular, the use of a suitable penetration enhancer results in the administration through the skin of that dosage of active ingredients which is required per unit of time to maintain the therapeutic level. Penetration enhancers can enhance the permeability of the skin without permanently harm the skin to -21- 2~2~7 the active ingredient and can be mixed with other pharmaceutically acceptable adjuncts.

Suitable penetration enhancers are preferably monovalent, saturated or unsaturated aliphatic, cycloaliphatic or aromatic alcohols having from 4 to 12 carbon atoms, e.g.
n-hexanol or cyclohexanol, aliphatic, cycloaliphatic or aromatic hydrocarbons having from S to 12 carbon atoms, e.g. hexane, cyclohexane, isopropylbenzene and the like, cycloaliphatic or aromatic aldehydes and ketones having from 4 to 10 carbon atoms, such as cyclohexanone, acetamide, N,N-di-lower alkylacetamides such as N,N-dimethyl-acetamide or N,N-diethylacetamide, Clo-C20alkanoylamides, e.g.
N,N-dimethyllauroylamide, l-n-Clo-C2oalkylazacycloheptan-2-one, e.g. -l-n-dodecylazacycloheptan-2-one (Azone(~), Nelson), pyrrolidones, such as N-methylpyrrolidone, polyalkylene glycol laureates, e.g. polyethylene glycol mono-laureate or N-2-hydroxyethylacetamide, and known vehicles and/or penetration enhancers such as aliphatic, cycloaliphatic and aromatic esters, N,N-di-lower alkyl sulfoxide, unsaturated oils, halogenated or nitrated aliphatic or cycloaliphatic hydrocarbons, salicylates, polyalkylene glycol silicates, and mixtures thereof.

C2-C4alkanols, e.g. isopropanol or isobutanol and, especially, ethanol, are especially preferred as penetration enhancers.

The amount of active ingredient, present in the therapeutic system, that is required to achieve a therapeutic effect depends on many factors: inter alia the minimum necessary dosage, the permeability of the membrane material, which determines the flux, and of the adhesive layer, and the period for which the plaster will be fixed to the skin or the mucous membranes. Since the active ingredient is to be released over a period of more than one day, there is, in fact, no upper limit to the maximum amounts of active ingredient present in the plaster. The minimum amount of active ingredient is determined by the requirement that sufficient, for example therapeutically effective, quantities of active ingredient must be present in the plaster to maintain the desired rate of release over the given period.

Adjuncts can be added to the active ingredients. Suitable adjuncts are water, isotonic aqueous sodium chloride solution, dextrose in water or sodium chloride solution, liquid glyceryl triesters with low molecular weight fatty acids, lower alkanols, natural oils such as corn oil, groandnut oil, sesame oil, castor oil and condensation products thereof with ethylene oxide, and the like, hydrocarbons such as pharmaceutical grade rnineral oil, silicones, emulsifiers such as monoglycerides or diglycerides of fatty acids, phospholipic acid derivatives such as lecithin or cephalin, polyalkylene glycols such as polyethylene glycol, aqueous phases to which a swelling agent such as sodium carboxymethylcellulose, sodium alginate, polyvinylpolypyrrolidone, etc. has been added and to which, in addition, dispersion agents or emulsi~lers such as lecithin may be added, polyoxyethylene and the like. The adjuncts may, in addition, contain additives such as preservatives, stabi]isers, wetting agents, emulsifiers, etc..

If C2-C4alkanols such as ethanol are used as penetration enhancers, gelling agents such as gelatin or swelling agents such as cellulose ethers, e.g. hydroxypropylcellulose, are preferably added as adjuncts to the active ingredient formulation.

The transdermal therapeutic systems of the invention are prepared in a manner known se, for example as follows: the adhesive layer (3) is applied to a base layer (peel-off protecting foil (4)), e.g. foil or film. The constituents of the active ingredient reservoir, for example membrane layer and active ingredient formulation, can also be applied to the base layer, and the impermeable backing foil can be placed on top. The plaster is then punched out of the master. The reservoir is optionally bonded to the backing foil with additional adhesive. The reservoir can also be hot-welded to the membrane layer or to the adhesive layer. In liquid-~llled systems, the membrane layer is applied to the adhesive layer and the active ingredient formulation is placed on the membrane.

The preparation processes are described in U.S. Patent Specification No. 3,797,494, preferably in DE-A-26 04 718 and DE-A-32 05 258 and in U.S. Patent Specifications 4,031,894 and 4,262,003 or in the publication by H. Asche in Schweiz. Rundschau Med.
(Praxis) 74, No. 11, 257-2~0 (1985), but the use according to the invention is not limited to the transdermal therapeutic systems described in those publications. The preferred transderrnal therapeutic system described in DE-A 32 05 258 is a therapeutic system in the form of a plaster-like patch that releases the active ingredient transdermally, avoiding side-effects, and delivers it through the skin so that the active ingredient content of the plasma remains approximately constant.

The daily dose of active ingredient for a patient weighing about 70 kg is. estimated to be from approximately 50 !lg to approximately 150 ~,~g, depending on the potency of the particuLIr active ingredient used.
The following Examples illustrate the invention described above, but they do not limit the scope thereof in any way.

2~2~;7 Example 1: Gel, containing as active ingredient, for example, 1 -hydroxy-2-(imidazol- 1-yl)-ethane- 1,1 -diphosphonic acid, having the following composition:
active ingredient 1.0 g Carbopol 934 P 1.0 g glycerol 3.0 g isopropanol 25.0 g Softigen 767 0.2 g demin. water q.s. ad 100.0 g Exarnple 2: Solution, containing as active ingredient, for example, 1-hydroxy-2-(imidazol- 1-yl)-ethane- 1,1-diphosphonic acid, having the following composition:
active ingredient 1.0 g isopropanol 60.0 g propylene glycol 10.0 g demin. water q.s. ad 100.0 g Example 3: Microemulsion, containing as active ingredient, for example, 1-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosphonic acid, having the following composition:
active ingredient 1.0 g Labrasol* 32.9 g Plurolisostearate** 13.2 g isostearyl isostearate 41.9 g demin. water q.s. ad 100.0 g * glyceryl caprylate/caprate (and) PEG-8 **polyglycerol-6-isostearate - 24 - .

Example 4: Cream (W/O), containing as active ingredient, for example, 1 -hydroxy-2-(imidazol- 1 -yl)-ethane- 1,1 -diphosphonic acid, having the following composition:
active ingredient 1.0 g cetyl alcohol 6.5 g cetyl palmitate 5.0 g stearylalcohol 6.5 g petroleum jelly 5.0 g glycerol 12.5 g sodium laurylsulfate 1.0 g methylparaben 0.18 g propylparaben 0.05 g demin. water q.s. ad 100.0 g E~xample 5: Ointment (O/W emulsion), containing as active ingredient, for example, l-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosphonic acid, having the following composition:
active ingredient 1.0 g cetyl alcohol 3.0 g glycerol 6.0 g methylparaben 0.18 g propylparaben 0.05 g Arlacel 60 0.6 g Tween 60 4.4 g stearic acid 9.0 g isopropyl palmitate 2.0 g paraffin oil, viscous 10.0 g demin. wate~ q3.s. ad 100.0 g Example 6: Water-free ointment, containing as active ingredient, for example, 1 -hydroxy-2-(imidazol- 1 -yl)-ethane- 1,1 -diphosphonic acid, having the -following composition:
active ingredient 1.0 g petroleum jelly 35.0 g paraffin oil, viscous 35.0 g Lanette N 30.0 g Example 7: Lotion, containing as active ingredient, for example, l-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosphonic acid, having the following composition:
active ingredient 1.0 g cetyl alcohol 1.9 g glycerol 4.3 g sodium laurylsulfate 1.0 g methylparaben 0.18 g propylparaben 0.05 g paraffin oil, viscous 2.5 g demin. water q.s. ad 100.0 g Example 8: Foam, containing as active ingredient, for example, 1 -hydroxy-2- (imidazol- 1 -yl)-ethane- 1,1 -diphDsphonic acid, having the following composition:
active ingredient 1.0 g cetyl alcohol 1.7 g glycerol 5.0 g methylparaben 0.18 g propylparaben 0.05 g isopropyl palmitate 2.0 g Arlacel 83 1.5 g Cetomacrogol 1000 2.4 g paraf~m oil, viscous 1.0 g demin. water q.s. ad 100.0 g Example 9: Monolith adhesive transderrnal system, containing as active ingredient, for example, 1-hydroxy-2-(imidaæol-1-yl)-ethane-1,1-diphosphonic acid Cornposition:
polyisobutylene (PIB) 3005.0 g (Oppanol B1, BASF) PIB 35000 3.0 g (Oppanol B10, BASF) PIB 1200000 9-0 g (Oppanol B100, BASF) hydrogenated hydrocarbon resin 43.0 g (Escorez 5320, Exxon) 1-dodecylazacycloheptan-2-one20.0 g (Azone, Nelson Res., Irvine/CA) active ingredient 20.0 g Total 100.0 g Preparation:
The above components are together dissolved in lS0 g of special boiling point petroleum fraction 100-125 by rolling on a roller gear bed. The solution is applied to a polyester film (Hostaphan, Kalle) by means of a spreading device using a 300 ~,1m doctor blade, giving a coating of about 75 g/m2. After drying (15 minutes at 60C), a silicone-treated polyester film (thickness 75 ~lm, Laufenberg) is applied as the peel-off film. The finished systems are punched out in siæes in the wanted form of from 5 to 30 cm2 using a punching tool.
The complete systems are sealed individually in sachets of aluminised paper.

- 27 ~
Examp!e 10: Matrix transdermal system with adhesive coating at the edge only, containing as active ingredient, for example, 1-hydroxy-2-(imidazol- 1 -yl)-ethane- 1,1 -diphosphonic acid Composition:
active ingredient 10.0 g hydroxypropylcellulose 1.0 g (Klucel HF) polyethylene glycol monolaurate 5.0 g demineralised water 84.0 g Preparation:
The constituents are dissolved in water, with stirring. A polyester film (~lostaphan, Kalle) is coated with silicone adhesive (Silicon Adhesive 355, Dow Corning, 55 % solid dissolved in special boiling point petroleum fraction 100-120) using a spreading device and a 150 ~,lm doctor blade, and is then dried (15 minutes, 60C).
Discs having a diameter of 2.5 cm (corresponding to a surface area of 5 cm2) are punched out of a non-woven fabric of viscose, polyamide and polypropylene (Vilmed type M 15397 Freudenberg) having a thickness of about 2.7 mm. After these discs have been bonded to the coated side of the polyester film, the above solution is metered onto the fabric discs in an amount of 450 mg per system by means of a micro-metering system. The discs are then covered with a silicone-treated polyester film. The individual systems are punched out using a tool having a diameter of 5 cm, care being taken to ensure that the fabric disc charged with the active ingredient solution is located in the centre of the system.
The finished systems are packed individually as described in Example 9.

Example 11: Membrane transdermal system, closed by means of a seal seam at the edge and containing as active ingredient, for example, 1 -hydroxy-2-(imidazol- 1-yl)-ethane- 1,1 -diphosphonic acid Composition:
active ingredient 10.0 g hydroxypropylcellulose (Klucel HF) 1.0 g polyethylene glycol monolaurate 5.0 g demineralised water 84.0 g Preparation:
The adhesive layer (silicone adhesive, see Example 10) is applied to a fluorine-treated polyester film by means of a screen printing process and dried. Application of a heat-sealable non-woven fabric of cellulose and polyester (Sontara Vlies 8412, DuPont) to form a laminate consisting of the peel-off film, the adhesive layer and the fabric.
The solution is applied by means of a micro-metering system to the above laminate (fabric on top) in an amount of 300 mg for a 5 cm2 system, a cover film of a heat-sealable poly-ester/ethyl vinyl acctate composite foil (Scotchpack 1220, 3M) is drawn over the laminate (ethyl vinyl acetate side towards the solution or fabric), and the system is sealed using a suitable heat-sealing tool (inside diameter 2.5 cm, outside diameter 3.5 cm; sealing conditions: 0.5 sec, 170C) and then punched out and packed individually as described in E~xample ~.

Example 12: System analogous to Example 11 Composition:
active ingredient 10.0 g hydroxypropylcellulose 3.0 g (Klucel H~) l-dodecylazacycloheptan-2-one 5.0 g (Azone, Nelson Res., Irvine CA) ethanol 50 % 84.0 g Preparation:
The constituents are dissolYed by stirring. Preparation and packing of the systems analogously to Example 11.

-29- 2~ 7 Example 13. ~atrix transdermal system consisting of two layers and containing as active ingredient, for example, l-hydroxy-2-(imidazol- 1 -yl)-ethane- 1,1 -diphosphonic acid Layer 1: Identical to the matrix of Example 9, the matrix being applied by means of a 150-250 ~lm doctor blade (rate of application 30-60 g/m2) to a silicone-treated polyester film (for speci~lcations see Example 9) and covered with a silicone-treated paper foil (temporary covering).

Layer 2: A suitable amount of flux enhancer (e.g. 5-25 % 1-dodecylazacycloheptan-2-one, Azone) is dissolved in the adhesive compound specified in Example 9 (dissolved in benzine) or in another suitable adhesive (e.g. copolymer based on acrylate esters and vinyl acetate, Durotak 280-2516, National Starch & Chemical BV, Zutphen/NL) without the active ingredient. The adhesive is laminated by means of a 150-30011m doctor blade and the intermediate layer is removed continously and discarded.
Further processing as in Example 9.

Example 14: Matrix transdermal system consisting of two layers and containing as active ingredient, for example, l-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosphonic acid Layer 1: As Example 13.

Layer 2: A suitable amount of flux enhancer is introduced into a customary hot-melt adhesive (e.g. acrylate adhesive Durotak 089-1526). A polyester film is applied with an aluminium foil by means of a hot-melt applicator at about 140-160C. The furtherprocessing of layers 1 and 2 is carried out as in Example 13.

Example 15: Reservoir-type membrane transdermal system, containing as active ingredient, for example, l-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosphonic acid Composition analogous to Example 11.

Onto the membrane side of a laminate consisting of peel-off film (polyester, silicone-treated on one side, thickness about 75 ~m;) adhesive (e.g. suitable mixture of polyisobutylene 1200000, polyisobutylene 35000 and polyisobutylene 1200; rate ofapplication 40-60 g/m2); regulation membrane (ethyl vinyl acetate containing 6-25 %
vinyl acetate, preferably 12-18 %, thickness about 50 ~lm) an amount of about 100-600 `2~o~

mg, depending on the system area provided, of the reservoir formlllation according to Example 18 is metered on a suitable apparatus.
Alternatively, the active ingredient, or a portion thereof, can be dissolved or suspended in the adhesive layer. In that case, the active ingredient contained in the adhesive layer would act as the initial dose and that in the reservo* as the maintenance dose.

In a manner analogous to that described in any one of the above Examples, it is possible to incorporate into the base layers other active ingredients of formula I, for example selected from 4-amino-1-hydroxybutane-1,1-diphosphonic acid, 6-amino-l-hydroxyhexane-l,l-diphosphonic acid, 3-(N-methyl-N-n-pentyl-amino)-l-hydroxypropane-l,l-diphosphonic acid, 3-[N-(3-phenylpropyl)-N-methyl-amino]-l-hydroxypropane-l,l-diphosphonic acid, 3-(N-methyl-N-5-phenylpentylamino)-1-hydroxypropane-1,1-diphosphonic acid, 3-[N-methyl-N-3-(2-pyridyl)-propylamino]- 1 -hydroxypropane- 1,1 -diphosphonic acid, 1 -hydroxy-3- [N-methyl-N-(3-phenoxypropyl)-amino]-propane-1,1-diphosphonic acid, 1-hydroxy-3-[N-methyl-N-(2-phenoxyethyl)-amino]-propane-1,1-diphosphonic acid, 4-(4-phenyl-piperidin- 1 -yl)- 1 -hydroxybutane- 1,1 -diphosphonic acid, 1 -hydroxy-3-( 1 -piperidino)-propane-l,l-diphosphonic acid, l-hydroxy-3-[3-(4-chlorophenyl)-pyrrolidin-1-yl]-propane-l,l-diphosphonic acid, l-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosph~nic acid, 2-(1-methylimidazol-2-yl)-ethane-1,1-diphosphonic acid, 1-hydroxy-2-(4-methyl-irnidazol-5-yl)-ethane-1,1-diphosphonic acid, 1-hydroxy-2-(imidazol-5-yl)-ethane-l,l-diphosphonic acid, l-hydroxy-2-(3-pyridyl)-ethane-1,1-diphosphonic acid, 2-(2-pyridyl)-ethane-1,1-diphosphonic acid, 1-[(S-n-butyl-2-thiazolyl)-amino]-methane-1,1-diphosphonic acid, 1-[(5-methyl-2-thiazolyl)-amino]-methane-1,1-diphosphonic acid, 1-[(2-thiazolyl)-amino]-methane-1,1-diphosphonic acid, l-hydroxyethane-l,l-diphosphonic acid, 1-(4-chlorophenylthio)-methane-1,1-diphosphonic acid, 1,1-dichloromethane-1,1-diphosphonic acid or 3-(1,5-dimethyl-3-azabicyclo[3.1.1]-hept-3-yl)-1-hydroxypropane-1,1-diphosphonic acid, and also 1-[(5-ethyl-2-thiazolyl)-amino]-methane-l,l-diphosphonic acid, 3-[N-(2-phenylethyl)-N-methylamino]- 1 -hydroxypropane- 1,1 -diphosphonic acid, 3-[N-(2-phenylthioethyl)-N-methylamino]-1-hydroxypropane-1,1-diphosphonic acid, l-hydroxy-3-(pyrrolidin-1-yl)-propane-1,1-diphosphonic acid or 2-(N-cycloheptylamino)-ethane-l,l-diphosphonic acid, or a pharmaceutically acceptable salt thereof.

Claims (18)

1. Topically administrable pharmaceutical preparations containing pharmaceutically acceptable methanediphosphonic acid derivatives of formula (I) and their salts, wherein each of R1 and R2 is halogen, or wherein R1 is hydrogen and R2 is Ar-S- or Hetl-NH-, in which Ar is unsubstituted or substituted phenyl and Hetl is unsubstituted or substituted, monocyclic, 5- or 6-membered monoaza-, diaza- or thiaza-aryl that is bonded via a ring carbon atom, or wherein R1 is hydrogen or hydroxy and R2 is -A-R3, in which A is alkylene and, on the one hand, R3 is Het2, which is Hetl bonded via a ring carbon or ring nitrogen atom, or, on the other hand, R3 is hydrogen, or amino that is unsubstituted or mono- or di-substituted by identical or different substituents selected from alkyl, cycloalkyl, Ar-alkyl, Ar-O-alkyl, Ar-S-alkyl and Het1-alkyl, or that is disubstituted by optionally Ar-containing alkylene, wherein two alkylene carbon atoms may additionally be linked to one another via alkylene and Ar and Het1 are each as defined above, with the proviso that when R2 is -A-R3, A is ethylene and R3 is unsub-stituted or C1-C3alkyl-substituted amino, R1 is other than hydroxy.

2. Preparatlons according to claim 1, containing a compound of forrnula I or a salt thereof, wherein each of R1 and R2 is halogen, or wherein R1 is hydrogen and R2 is Ar-S- or Het1-NH-, in which Ar is unsubstituted or substituted phenyl and Hetl is unsubstituted or substituted, monocyclic, 5-or 6-membered monoaza-, diaza- or thiaza-aryl that is bonded via a ring carbon atom, or wherein R1 is hydrogen or hydroxy and R2 is -A-R3, in which A is alkylene and, on the one hand, R3 is Het2, which is Het1 bonded via a ring carbon or ring nitrogen atom, or, on the other hand, R3 is hydrogen, or amino that is unsubstituted or mono- or di-substituted by identical or different substituents selected from alkyl, Ar-alkyl, Ar-O-alkyl and Het1-alkyl, or that is di-substituted by optionally Ar-containing alkylene, wherein two alkylene carbon atoms may additionally be linked to one another via alkylene and Ar and Het1 are each as defined above.

3. Preparations according to claim 2, containing a compound of formula I or a salt thereof, wherein each of R1 and R2 is halogen, or wherein R1 is hydrogen and R2 is Ar-S- or Hetl-NH-, in which Ar is phenyl that is unsubstituted or substituted by lower alkyl, lower alkoxy, trifluoromethyl and/or, especially, by halogen, and Het1 is unsubstituted or lower alkyl-substituted thiazolyl, or wherein R1 is hydrogen or hydroxy and R2 is -A-R3, in which A is lower alkylene and, on the one hand, R3 is unsubstituted or lower alkyl-substi-tuted imidazolyl that is bonded via a ring carbon or ring nitrogen atom, or is pyridyl, or, on the other hand, R3 is hydrogen, or amino that is unsubstituted or mono- or di-substituted by identical or different substituents selected from lower alkyl, C3-C7-cycloalkyl, Ar-lower alkyl, Ar-O-lower alkyl and pyridyl-lower alkyl, or that is disubstituted by optionally Ar-containing lower alkylene or by lower alkylene wherein two non-adjacent lower alkylene carbon atoms are additionally linked to one another via lower alkylene, and Ar in each case is as defined above.

4. Preparations according to claim 3, containing a compound of formula I or a salt thereof, wherein R1 is hydrogen or hydroxy and R2 is -A-R3, in which A is lower alkylene and R3 is amino that is mono- or di-substituted by identical or different substituents selected from lower alkyl, Ar-lower alkyl, C3-C7-cycloalkyl, Ar-O-lower alkyl, Ar-S-lower alkyl and pyridyl-lower alkyl.

5. Preparations according to claim 2, containing a compound of formula I or a salt, especially an alkali metal salt, for example sodium salt, thereof, wherein each of R1 and R2 is halogen, especially chlorine, or wherein R1 is hydrogen and R2 is phenylthio that is unsubstituted or substituted by halogen, such as chlorine, for example 4-chlorophenylthio, or thiazolylamino that is unsubstituted or substituted by lower alkyl, especially C1-C4alkyl, such as methyl, for example thiazol-2-yl-, 5-n-butylthiazol-2-yl- or5-methylthiazol-2-yl-amino, or wherein R1 is hydrogen or hydroxy and R2 is -A-R3 in which A is C1-C7alkylene, such as methylene, ethylene, propylene or pentylene, and R3 is imidazolyl that is bonded via a ring carbon or ring nitrogen atom and is unsubstituted or substituted by lower alkyl, especially C1-C4alkyl, such as methyl, for example imidazol-1-yl, imidazol-5-yl, 1-methylimidazol-2-yl or 4-methylimidazol-5-yl, or is pyridyl, such as 2- or 3-pyridyl, or wherein R1 is hydroxy and R2 is -A-R3 in which A is as defined above and R3 is amino, di-C1-C5alkylamino, such as dimethylamino, N-methyl-N-n-propylarnino or N-methyl-N-n-pentylamino, N-Cl-C4alkyl-N-phenyl-C1-C5aLkylamino, such as N-methyl-N-(3-phenylpropyl)-amino or N-methyl-N-(5-phenylpentyl)-amino, N-C1-C4alkyl-N-pyridyl-C1-C4alkylamino, such as N-methyl-N-[3-(2-pyridyl)-propyl]-amino, C4-C6alkyleneamino that is unsubstituted or substituted by phenyl which may contain halogen, such as chlorine, such as 4-chlorophenyl, for example piperidin-1-yl that is unsubstituted or substituted, especially in the 4-position, by phenyl, or pyrrolidin-1-yl that is unsubstituted or substituted, especially in the 3-position, by 4-chlorophenyl, or 1,5-di-C1-C4alkyl-, such as 1,5-di-methyl-3-azabicyclo[3.1.1]hept-3-yl, or wherein R1 is hydroxy and R2 is -A-R3 in which A is C1-C4alkylene, especially methylene, and R3 is hydrogen.

6. Preparations according to claim 5, containing a compound of formula I or a salt thereof, wherein R1 is hydrogen or hydroxy and R2 is -A-R3, in which A is C1-C7alkylene, such as methylene, ethylene, propylene or pentylene, and R3 is N-C3-C7-cyclcalkylamino, such as cycloheptylamino, or N-C1-C4alkyl-N-phenylthio-C1-C4alkyl, such as N-methyl-N-(2-phenylthioethyl)-amino.

7. Preparations according to claim 2, containing a compound of formula I or a salt, especially an alkali metal salt, for example sodium salt, thereof, wherein R1 is hydroxy and R2 is -A-R3, in which A is C1-C7alkylene, such as ethylene, propylene or pentylene, and R3 is amino, di-C1-C4alkylamino, such as dimethyl- or N-methyl-N-n-propyl-amino, or N-C1-C4alkyl-N-phenyl-C1-C4alkylamino, such as N-methyl-N-(3-phenylpropyl)-amino.

8. Preparations according to claim 2, containing a compound of formula I or a salt, especially an alkali metal salt, for example sodium salt, thereof, wherein R1 is hydroxy and R2 is -A-R3, in which A is C1-C7alkylene, especially C1-C4alkylene, such as methylene, and R3 is imidazolyl that is bonded via a ring carbon or ring nitrogen atom and is unsubstituted or substituted by C1-C4alkyl, such as methyl, for example imidazol-1-yl, imidazol-5-yl, 1-methylimidazol-2-yl or 4-methylimidazol-5-yl.

9. Preparations according to claim 2, containing a pharmaceutically effective methanediphosphonic acid selected from the following compounds of formula I:
4-amino-1-hydroxybutane-1,1-diphosphonic acid, 6-amino-1-hydroxyhexane-1,1-diphosphonic acid, 3-(N-methyl-N-n-pentylamino)-1-hydroxypropane-1,1-diphosphonic acid, 3-[N-(3-phenylpropyl)-N-methylamino]-1-hydroxypropane-1,1-diphosphonic acid, 3-(N-methyl-N-5-phenylpentylamino)-1-hydroxypropane 1,1-diphosphonic acid, 3-[N-methyl-N-3-(2-pyridyl)-propylamino]-1-hydroxypropane- 1,1-diphosphonic acid, 1-hydroxy-3-[N-methyl-N-(3-phenoxypropyl)-amino]-propane-1,1-diphosphonic acid, 1-hydroxy-3-[N-methyl-N-(2-phenoxyethyl)-amino]-propane-1,1-diphosphonic acid, 4-(4-phenylpiperidin-1-yl)-1-hydroxybutane-1,1-diphosphonic acid, 1-hydroxy-3-(1-piper-idino)-propane-1,1-diphosphonic acid, 1-hydroxy-3-[3-(4-chlorophenyl)-pyrrolidin-1-yl]-propane-1,1-diphosphonic acid, 1-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosphonic acid, 2-(1-methylimidazol-2-yl)-ethane- 1,1 -diphosphonic acid, 1 -hydroxy-2-(4-methylimidazol-5-yl)-ethane- 1,1 -di-phosphonic acid, 1-hydroxy-2-(imidazol-5-yl)-ethane-1,1-diphosphonic acid, 1-hydroxy-2-(3-pyridyl)-ethane-1,1-diphosphonic acid, 2-(2-pyridyl)-ethane-1,1-diphosphonic acid, 1-[(5-n-butyl-2-thiazolyl)-amino]-methane-1,1-diphosphonic acid, 1-[(5-methyl-2-thiazolyl)-amino]-methane-1,1-diphosphonic acid, 1-[(2-thiazolyl)-amino]-methane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, 1-(4-chlorophenylthio)-methane-1,1-diphosphonic acid, 1,1-dichloromethane-1,1-diphosphonic acid, or 3-(1,5-dimethyl-3-azabicyclo[3.1.1]hept-3-yl)-1-hydroxypropane-1,1-diphosphonic acid, or a pharmaceutically acceptable salt thereof.

10. Preparations according to claim 1, containing a pharmaceutically effective methanediphosphonic acid selected from the following compounds of formula I:
1-[(5-ethyl-2-thiazolyl)-amino]-methane-1,1-diphosphonic acid, 3-[N-(2-phenylethyl)-N-methylamino]-1-hydroxypropane-1,1-diphosphonic acid and 3-[N-(2-phenylthioethyl)-N-methylamino]-1-hydroxypropane- 1,1-diphosphonic acid, 1-hydroxy-3-(pyrrolidin- 1 -yl)-propane- 1,1 -diphosphonic acid and 2-(N-cycloheptylamino)-ethane-1,1-diphosphonic acid, or a pharmaceutically acceptable salt thereof.

11. Preparations according to claim 2, containing 1-hydroxy-2-(imidazol-1-yl)-ethane-1,1-diphosphonic acid or a pharmaceutically acceptable salt thereof.

12. Preparations according to any one of claims 1 to 11 in the form of creams, gels, ointments, lotions, pastes, foams, tinctures, microemulsions or solutions.

13. Preparations according to any one of claims 1 to 11 in the form of multi-layered therapeutic systems for transdermal administration.

14. Preparations according to claim 13, wherein the multi-layered therapeutic systems for transdermal administration contain the following constituents:

(1) a closed backing foil which is impermeable to the subsequent layers of the consti-tuents of the active ingredient formulation, (2) a reservoir for the active ingredient, next to the backing foil, provided that the active ingredient is not already present in the adhesive foil, (3) an adhesive layer and (4) a peel-off protecting foil.

15. Preparations according to any one of claims 1 to 11, 13 and 14 in the form of multi-layered therapeutic systems for transdermal administration of the matrix type or the membrane type.

16. The pharmaceutical preparations described in the Examples and processes for the manufacture thereof.

17. A method of increasing the absorption of pharmaceutically acceptable methanediphosphonic acid derivatives of formula I, which comprises incorporating a compound of formula I or a salt thereof according to any one of claims 1 to 16 into a pharmaceutical composition for topical administration and applying it to a warm-blooded animal including man.

18. The use of topically administrable pharmaceutical preparations according to any one of claims 1 to 16 in the treatment of hypercalcaemia and osteolytic bone metastases.