CA2022564A1 - Apparatus for repeated automatic execution of a thermal cycle for treatment of samples - Google Patents

Apparatus for repeated automatic execution of a thermal cycle for treatment of samples

Info

Publication number
CA2022564A1
CA2022564A1 CA2022564A CA2022564A CA2022564A1 CA 2022564 A1 CA2022564 A1 CA 2022564A1 CA 2022564 A CA2022564 A CA 2022564A CA 2022564 A CA2022564 A CA 2022564A CA 2022564 A1 CA2022564 A1 CA 2022564A1
Authority
CA
Canada
Prior art keywords
treatment
sample
pathway
samples
thermal cycle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2022564A
Other languages
French (fr)
Other versions
CA2022564C (en
Inventor
Daniel Larzul
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of CA2022564A1 publication Critical patent/CA2022564A1/en
Application granted granted Critical
Publication of CA2022564C publication Critical patent/CA2022564C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/088—Channel loops
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00435—Refrigerated reagent storage

Abstract

Apparatus for repeated automatic execution of a thermal cycle for the treatment of a sample, especially a biological sample, comprises means (6) defining a pathway which is physically closed throughout the treatment and within which the sample is resident throughout the treatment. Means (3, 4, 11, 12) are provided to move the sample between different positions along the pathway and (7, 15, 16) to heat or cool the sample as a function of its position within the pathway.

Preferably the pathway is a capillary tube, which may be in spiral, closed loop or linear form. Heating and cooling means are provided by thermostated zones which may provide a continuous thermal gradient, regular or irregular, or be in a discontinuous arrangment. The preferred means of moving the samples is magnetic.
CA002022564A 1989-08-05 1990-08-02 Apparatus for repeated automatic execution of a thermal cycle for treatment of samples Expired - Fee Related CA2022564C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898917963A GB8917963D0 (en) 1989-08-05 1989-08-05 Apparatus for repeated automatic execution of a thermal cycle for treatment of biological samples
GB8917963.4 1989-08-05

Publications (2)

Publication Number Publication Date
CA2022564A1 true CA2022564A1 (en) 1991-02-06
CA2022564C CA2022564C (en) 1996-03-05

Family

ID=10661242

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002022564A Expired - Fee Related CA2022564C (en) 1989-08-05 1990-08-02 Apparatus for repeated automatic execution of a thermal cycle for treatment of samples

Country Status (30)

Country Link
US (1) US5176203A (en)
JP (1) JP3058661B2 (en)
AR (1) AR243600A1 (en)
AT (1) AT403165B (en)
AU (1) AU643225B2 (en)
BE (1) BE1004524A3 (en)
CA (1) CA2022564C (en)
CH (1) CH681431A5 (en)
DE (1) DE4024714C2 (en)
DK (1) DK185990A (en)
ES (1) ES2027111A6 (en)
FI (1) FI903856A0 (en)
FR (1) FR2650657A1 (en)
GB (2) GB8917963D0 (en)
GR (1) GR1000653B (en)
HK (1) HK33194A (en)
IE (1) IE65524B1 (en)
IN (1) IN177441B (en)
IT (1) IT1243976B (en)
LU (1) LU87782A1 (en)
MA (1) MA21926A1 (en)
MY (1) MY107255A (en)
NL (1) NL9001772A (en)
NO (1) NO903423L (en)
NZ (1) NZ234736A (en)
OA (1) OA09742A (en)
PT (1) PT94899B (en)
SE (1) SE9002566L (en)
TN (1) TNSN90110A1 (en)
ZA (1) ZA905935B (en)

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AU643225B2 (en) 1993-11-11
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CA2022564C (en) 1996-03-05
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US5176203A (en) 1993-01-05
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