CA2023968A1 - Living tissue equivalents - Google Patents
Living tissue equivalentsInfo
- Publication number
- CA2023968A1 CA2023968A1 CA2023968A CA2023968A CA2023968A1 CA 2023968 A1 CA2023968 A1 CA 2023968A1 CA 2023968 A CA2023968 A CA 2023968A CA 2023968 A CA2023968 A CA 2023968A CA 2023968 A1 CA2023968 A1 CA 2023968A1
- Authority
- CA
- Canada
- Prior art keywords
- tissue equivalents
- living tissue
- equivalents
- present
- provides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
- C12N5/0698—Skin equivalents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
- C12M25/02—Membranes; Filters
- C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
- C12N2502/094—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells keratinocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
- C12N2502/1323—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/50—Proteins
- C12N2533/54—Collagen; Gelatin
Abstract
The present invention provides improved tissue equivalents and methods of making and using such tissue equivalents. The present invention also provides test apparatus incorporating such improved tissue equivalents.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002298856A CA2298856C (en) | 1989-09-15 | 1990-08-24 | Living tissue equivalents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40805289A | 1989-09-15 | 1989-09-15 | |
US07/408,052 | 1989-09-15 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002298856A Division CA2298856C (en) | 1989-09-15 | 1990-08-24 | Living tissue equivalents |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2023968A1 true CA2023968A1 (en) | 1991-03-16 |
CA2023968C CA2023968C (en) | 2000-05-02 |
Family
ID=23614662
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002298856A Expired - Fee Related CA2298856C (en) | 1989-09-15 | 1990-08-24 | Living tissue equivalents |
CA002023968A Expired - Fee Related CA2023968C (en) | 1989-09-15 | 1990-08-24 | Living tissue equivalents |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002298856A Expired - Fee Related CA2298856C (en) | 1989-09-15 | 1990-08-24 | Living tissue equivalents |
Country Status (12)
Country | Link |
---|---|
US (1) | US5536656A (en) |
EP (1) | EP0418035B1 (en) |
JP (1) | JPH03151977A (en) |
KR (1) | KR940001379B1 (en) |
AT (1) | ATE119194T1 (en) |
AU (1) | AU6215690A (en) |
CA (2) | CA2298856C (en) |
DE (1) | DE69017324T2 (en) |
DK (1) | DK0418035T3 (en) |
ES (1) | ES2071778T3 (en) |
IE (1) | IE903340A1 (en) |
IL (1) | IL95429A (en) |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5888720A (en) * | 1992-10-27 | 1999-03-30 | Yissum Research And Development Company Of The Hebrew University Of Jerusalem | In vitro micro-organs |
CA2119064A1 (en) * | 1993-03-17 | 1994-09-18 | Richard A. Berg | Dermal-epidermal in vitro test system |
GB9306449D0 (en) | 1993-03-29 | 1993-05-19 | Nat Heart Research Fund | Tissue equivalents |
US5693085A (en) * | 1994-04-29 | 1997-12-02 | Scimed Life Systems, Inc. | Stent with collagen |
US5665114A (en) * | 1994-08-12 | 1997-09-09 | Meadox Medicals, Inc. | Tubular expanded polytetrafluoroethylene implantable prostheses |
US5891558A (en) * | 1994-11-22 | 1999-04-06 | Tissue Engineering, Inc. | Biopolymer foams for use in tissue repair and reconstruction |
US5965125A (en) * | 1995-10-25 | 1999-10-12 | Transkaryotic Therapies, Inc. | Hybrid matrix implants and explants |
US6419920B1 (en) | 1995-10-25 | 2002-07-16 | Trans Karyotic Therapies, Inc. | Hybrid matrix implants and explants |
US5955353A (en) * | 1997-05-22 | 1999-09-21 | Excorp Medical, Inc. | Hollow fiber bioreactor with an extrafilament flow plug |
US20020086423A1 (en) * | 1997-09-09 | 2002-07-04 | Toshiaki Takezawa | Hydrogel thin film containing extracellular matrix components |
WO1999046285A2 (en) | 1998-03-11 | 1999-09-16 | University Of Southern California | Method of promoting production of living tissue equivalents |
US6129757A (en) | 1998-05-18 | 2000-10-10 | Scimed Life Systems | Implantable members for receiving therapeutically useful compositions |
WO2000029553A1 (en) * | 1998-11-19 | 2000-05-25 | Organogenesis Inc. | Bioengineered tissue constructs and methods for producing and using them |
US7001746B1 (en) * | 1999-01-29 | 2006-02-21 | Artecel Sciences, Inc. | Methods and compositions for the differentiation of human preadipocytes into adipocytes |
WO2000047129A2 (en) * | 1999-02-11 | 2000-08-17 | The General Hospital Corporation | Microfabricated membranes and matrices |
US6197061B1 (en) * | 1999-03-01 | 2001-03-06 | Koichi Masuda | In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage |
EP1203075B1 (en) | 1999-06-21 | 2007-09-12 | The General Hospital Corporation | Cell culture systems and methods for organ assist devices |
WO2001014527A1 (en) * | 1999-08-23 | 2001-03-01 | Organogenesis Inc. | Skin care compositions and treatments |
EP1918366A1 (en) | 2000-02-26 | 2008-05-07 | Artecel, Inc. | Pleuripotent stem cells generated from adipose tissue-derived stromal cells and uses thereof |
US7582292B2 (en) | 2000-02-26 | 2009-09-01 | Artecel, Inc. | Adipose tissue derived stromal cells for the treatment of neurological disorders |
ES2300320T3 (en) * | 2000-02-26 | 2008-06-16 | Artecel, Inc. | PLURIPOTENT MOTHER CELLS GENERATED FROM STROMA CELLS DERIVED FROM ADIPOSE TISSUE AND ITS USES. |
WO2001092476A2 (en) * | 2000-05-31 | 2001-12-06 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | In vitro tissue test system |
CA2410956C (en) | 2000-05-31 | 2012-12-04 | Michaela Noll | Three-dimensional skin model |
US7144729B2 (en) | 2000-09-01 | 2006-12-05 | Dfb Pharmaceuticals, Inc. | Methods and compositions for tissue regeneration |
CA2422861C (en) | 2000-09-18 | 2012-06-19 | Organogenesis Inc. | Method for treating a patient using a cultured connective tissue construct |
EP1832300A3 (en) * | 2000-09-18 | 2008-02-27 | Organogenesis Inc. | Method for treating a patient using a cultured connective tissue construct |
US7041868B2 (en) | 2000-12-29 | 2006-05-09 | Kimberly-Clark Worldwide, Inc. | Bioabsorbable wound dressing |
US6974697B2 (en) * | 2001-03-02 | 2005-12-13 | Stratech Corporation | Skin substitutes with improved barrier function |
AU2002255618B2 (en) * | 2001-03-02 | 2006-09-07 | Stratatech Corporation | Improved skin substitutes and uses thereof |
US20030211793A1 (en) * | 2001-03-05 | 2003-11-13 | Eugene Bell | Injectable bio-compatible material and methods of use |
JP3960969B2 (en) | 2001-06-14 | 2007-08-15 | ミリポア・コーポレイション | Tray with protrusion |
JP2005506860A (en) * | 2001-09-15 | 2005-03-10 | ラツシユ−プレスビテリアン−セント・リユークズ・メデイカル・センター | Layered cartilage tissue and engineering method thereof |
US20030165473A1 (en) * | 2001-11-09 | 2003-09-04 | Rush-Presbyterian-St. Luke's Medical Center | Engineered intervertebral disc tissue |
AU2003219830A1 (en) * | 2002-02-22 | 2003-09-09 | Ebi, L.P. | Methods and compositions for treating bone or cartilage defects |
US7741116B2 (en) | 2002-03-06 | 2010-06-22 | University Of Cincinnati | Surgical device for skin therapy or testing |
JP4753577B2 (en) * | 2002-04-30 | 2011-08-24 | ストラタテック コーポレーション | Keratinocytes expressing exogenous angiogenic growth factors |
US7229820B2 (en) * | 2002-06-13 | 2007-06-12 | Wilson Wolf Manufacturing Corporation | Apparatus and method for culturing and preserving tissue constructs |
WO2004013606A2 (en) * | 2002-08-02 | 2004-02-12 | Stratatech Corporation | Species specific dna detection |
PT3100611T (en) * | 2003-08-01 | 2018-12-14 | Stratatech Corp | Human skin equivalents expressing exogenous polypeptides |
FR2881434B1 (en) * | 2005-02-02 | 2007-05-11 | Coletica Sa | DEVICE FOR SUPPORTING CELL CULTURE |
JP4993752B2 (en) | 2005-03-01 | 2012-08-08 | ストラタテック コーポレーション | Human skin equivalent expressing exogenous polypeptide |
WO2006101834A1 (en) | 2005-03-17 | 2006-09-28 | Stratatech Corporation | Skin substitutes with improved purity |
FR2889808B1 (en) | 2005-08-17 | 2011-07-22 | Oreal | USE OF 8-HEXADECENE-1,16-DICARBOXYLIC ACID AS A CARE AGENT TO PROMOTE COHESION OF THE CORNEA LAYER |
US9782515B2 (en) * | 2006-03-03 | 2017-10-10 | Organogenesis, Inc. | Oral tissue regeneration and repair |
FR2903702B1 (en) | 2006-07-13 | 2012-10-19 | Oreal | EQUIVALENT OF EPIDERM CAPABLE OF PIGMENTING OBTAINED FROM CELLS OF THE MATRIX, PROCESS FOR THEIR PREPARATION AND USE |
US8932619B2 (en) * | 2007-06-27 | 2015-01-13 | Sofradim Production | Dural repair material |
US20090068250A1 (en) * | 2007-09-07 | 2009-03-12 | Philippe Gravagna | Bioresorbable and biocompatible compounds for surgical use |
WO2009043052A1 (en) * | 2007-09-27 | 2009-04-02 | Columbia University | Methods and systems for forming biocompatible materials |
WO2009065005A1 (en) | 2007-11-14 | 2009-05-22 | Stratatech Corporation | Cold storage of organotypically cultured skin equivalents for clinical applications |
US9308068B2 (en) | 2007-12-03 | 2016-04-12 | Sofradim Production | Implant for parastomal hernia |
CN104491845A (en) | 2008-04-18 | 2015-04-08 | 科尔普兰特有限公司 | Methods Of Generating And Using Procollagen |
US9242026B2 (en) | 2008-06-27 | 2016-01-26 | Sofradim Production | Biosynthetic implant for soft tissue repair |
WO2010048441A2 (en) * | 2008-10-22 | 2010-04-29 | Regenemed, Inc. | Culture systems |
PT2352472T (en) * | 2008-11-04 | 2017-04-11 | Stratatech Corp | Dried and irradiated skin equivalents for ready use |
WO2010111278A1 (en) | 2009-03-23 | 2010-09-30 | The Texas A&M University System | Compositions of mesenchymal stem cells to regenerate bone |
WO2010135655A2 (en) | 2009-05-21 | 2010-11-25 | Stratatech Corporation | Human skin substitutes expressing il-12 |
US9321988B2 (en) * | 2009-06-18 | 2016-04-26 | Illinois Tool Works Inc. | Gas and liquid tissue culture interface |
FR2949688B1 (en) | 2009-09-04 | 2012-08-24 | Sofradim Production | FABRIC WITH PICOTS COATED WITH A BIORESORBABLE MICROPOROUS LAYER |
SG184385A1 (en) * | 2010-04-05 | 2012-11-29 | Emd Millipore Corp | Polymeric membranes with human skin like permeability properties and uses thereof |
FR2967163A1 (en) | 2010-11-05 | 2012-05-11 | Centre Nat Rech Scient | IN VITRO OR EX VIVO METHOD FOR SURVIVAL MAINTENANCE AND GENERATION OR RECONSTRUCTION OF AN EPIDERM |
FR2972626B1 (en) | 2011-03-16 | 2014-04-11 | Sofradim Production | PROSTHETIC COMPRISING A THREE-DIMENSIONAL KNIT AND ADJUSTED |
FR2976001B1 (en) | 2011-05-30 | 2014-10-31 | Oreal | RECONSTRUCTED SCALP LEATHER MODEL AND METHOD FOR SCREENING ACTIVE MOLECULES |
FR2977790B1 (en) | 2011-07-13 | 2013-07-19 | Sofradim Production | PROSTHETIC FOR UMBILIC HERNIA |
FR2977789B1 (en) | 2011-07-13 | 2013-07-19 | Sofradim Production | PROSTHETIC FOR UMBILIC HERNIA |
EP2760494B1 (en) | 2011-09-30 | 2017-04-19 | Sofradim Production | Reversible stiffening of light weight mesh |
EP2760431A1 (en) | 2011-09-30 | 2014-08-06 | Sofradim Production | Multilayer implants for delivery of therapeutic agents |
FR2985170B1 (en) | 2011-12-29 | 2014-01-24 | Sofradim Production | PROSTHESIS FOR INGUINAL HERNIA |
FR2985271B1 (en) | 2011-12-29 | 2014-01-24 | Sofradim Production | KNITTED PICOTS |
FR2994185B1 (en) | 2012-08-02 | 2015-07-31 | Sofradim Production | PROCESS FOR THE PREPARATION OF A POROUS CHITOSAN LAYER |
PL226837B1 (en) | 2012-08-24 | 2017-09-29 | Celther Polska Spółka Z Ograniczoną Odpowiedzialnością | Active polymer layer formed of chitin derivatives, especially for dressing and its use |
FR2995779B1 (en) | 2012-09-25 | 2015-09-25 | Sofradim Production | PROSTHETIC COMPRISING A TREILLIS AND A MEANS OF CONSOLIDATION |
FR2995788B1 (en) | 2012-09-25 | 2014-09-26 | Sofradim Production | HEMOSTATIC PATCH AND PREPARATION METHOD |
FR2995778B1 (en) | 2012-09-25 | 2015-06-26 | Sofradim Production | ABDOMINAL WALL REINFORCING PROSTHESIS AND METHOD FOR MANUFACTURING THE SAME |
AU2013322268B2 (en) | 2012-09-28 | 2017-08-31 | Sofradim Production | Packaging for a hernia repair device |
DK2967836T3 (en) | 2013-03-13 | 2019-01-28 | Stratatech Corp | Cryopreservation of viable human skin substitutes |
AU2014259787B2 (en) | 2013-05-03 | 2018-03-08 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Skin substitutes and methods for hair follicle neogenesis |
FR3006578B1 (en) | 2013-06-07 | 2015-05-29 | Sofradim Production | PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY |
FR3006581B1 (en) | 2013-06-07 | 2016-07-22 | Sofradim Production | PROSTHESIS BASED ON TEXTILE FOR LAPAROSCOPIC PATHWAY |
WO2015166455A1 (en) | 2014-04-30 | 2015-11-05 | Fondazione Istituto Italiano Di Tecnologia | Method for producing a totally endogenous bioengineered tissue and tissue obtained thereby |
EP3000489B1 (en) | 2014-09-24 | 2017-04-05 | Sofradim Production | Method for preparing an anti-adhesion barrier film |
EP3000433B1 (en) | 2014-09-29 | 2022-09-21 | Sofradim Production | Device for introducing a prosthesis for hernia treatment into an incision and flexible textile based prosthesis |
EP3000432B1 (en) | 2014-09-29 | 2022-05-04 | Sofradim Production | Textile-based prosthesis for treatment of inguinal hernia |
EP3029189B1 (en) | 2014-12-05 | 2021-08-11 | Sofradim Production | Prosthetic porous knit, method of making same and hernia prosthesis |
EP3059255B1 (en) | 2015-02-17 | 2020-05-13 | Sofradim Production | Method for preparing a chitosan-based matrix comprising a fiber reinforcement member |
EP3085337B1 (en) | 2015-04-24 | 2022-09-14 | Sofradim Production | Prosthesis for supporting a breast structure |
ES2676072T3 (en) | 2015-06-19 | 2018-07-16 | Sofradim Production | Synthetic prosthesis comprising a knitted fabric and a non-porous film and method of forming it |
EP3195830B1 (en) | 2016-01-25 | 2020-11-18 | Sofradim Production | Prosthesis for hernia repair |
FR3054449B1 (en) | 2016-07-29 | 2018-08-31 | L'oreal | EQUIVALENT OF SKIN WITH DERMAL COMPARTMENTS SEPARATE JUXTAPOSES |
EP3312325B1 (en) | 2016-10-21 | 2021-09-22 | Sofradim Production | Method for forming a mesh having a barbed suture attached thereto and the mesh thus obtained |
EP3398554A1 (en) | 2017-05-02 | 2018-11-07 | Sofradim Production | Prosthesis for inguinal hernia repair |
WO2018220137A1 (en) * | 2017-05-31 | 2018-12-06 | ETH Zürich | Assembly for the production of tissue implants |
FR3071512B1 (en) | 2017-09-28 | 2022-02-25 | Oreal | MOLECULAR SIGNATURES OF THREE SUB-POPULATIONS OF DERMAL FIBROBLASTS AND DERMIS EQUIVALENT COMPRISING ONE OF THESE SUB-POPULATIONS |
EP3653171A1 (en) | 2018-11-16 | 2020-05-20 | Sofradim Production | Implants suitable for soft tissue repair |
FR3111904B1 (en) | 2020-06-30 | 2022-10-21 | Oreal | Bioink for bioprinting of an invaginated dermal-epidermal junction model |
LU502391B1 (en) | 2022-06-28 | 2024-01-09 | Univerza V Mariboru | A complex in vitro model of human skin, a process for preparation and use thereof |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2677646A (en) * | 1952-03-22 | 1954-05-04 | Lovell Chemical Company | Unit for bacterial analysis |
US2761813A (en) * | 1953-01-21 | 1956-09-04 | Goetz Alexander | Means and method of producing and controlling cultures of microorganisms |
GB1594389A (en) * | 1977-06-03 | 1981-07-30 | Max Planck Gesellschaft | Dressing material for wounds |
DE2967509D1 (en) * | 1978-12-26 | 1985-10-10 | Massachusetts Inst Technology | Skin-equivalent |
US4290911A (en) * | 1979-02-07 | 1981-09-22 | Fmc Corporation | Agarose composition, aqueous gel and method of making same |
SE7908454L (en) * | 1979-10-11 | 1981-04-12 | Pharmacia Fine Chemicals Ab | ISOELECTRIC FOCUS MEDIUM |
US4539716A (en) * | 1981-03-19 | 1985-09-10 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
US4546500A (en) * | 1981-05-08 | 1985-10-15 | Massachusetts Institute Of Technology | Fabrication of living blood vessels and glandular tissues |
US4505266A (en) * | 1981-10-26 | 1985-03-19 | Massachusetts Institute Of Technology | Method of using a fibrous lattice |
US4485096A (en) * | 1982-02-26 | 1984-11-27 | Massachusetts Institute Of Technology | Tissue-equivalent and method for preparation thereof |
US4485097A (en) * | 1982-05-26 | 1984-11-27 | Massachusetts Institute Of Technology | Bone-equivalent and method for preparation thereof |
US4598045A (en) * | 1982-08-25 | 1986-07-01 | Hana Biologics, Inc. | Triphasic mycoplasmatales detection method |
US4734372A (en) * | 1983-02-04 | 1988-03-29 | Brown University Research Foundation | Cell culturing methods and apparatus |
US4578354A (en) * | 1983-05-09 | 1986-03-25 | Pfizer Inc. | Immobilization of catalytically active microorganisms in agar gel fibers |
EP0164583B1 (en) * | 1984-05-11 | 1991-09-25 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Method for manufacture a container made of synthetic resin |
US4604346A (en) * | 1984-10-09 | 1986-08-05 | Massachusetts Institute Of Technology | Skin-equivalent prepared by the use of punch biopsy |
JPS6225974A (en) * | 1985-07-25 | 1987-02-03 | Asahi Chem Ind Co Ltd | Gelatinous composition consisting of collagen |
US5026649A (en) * | 1986-03-20 | 1991-06-25 | Costar Corporation | Apparatus for growing tissue cultures in vitro |
US5032508A (en) * | 1988-09-08 | 1991-07-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US4963489A (en) * | 1987-04-14 | 1990-10-16 | Marrow-Tech, Inc. | Three-dimensional cell and tissue culture system |
US5037656A (en) * | 1986-12-04 | 1991-08-06 | Millipore Corporation | Porous membrane having hydrophilic and cell growth promotions surface and process |
FR2612939B1 (en) * | 1987-03-26 | 1989-06-23 | Cird | SKIN EQUIVALENT |
FR2612938B1 (en) * | 1987-03-26 | 1989-06-23 | Cird | METHOD FOR OBTAINING A SKIN EQUIVALENT AND CORRESPONDING SKIN EQUIVALENT |
US4835102A (en) * | 1987-03-31 | 1989-05-30 | Eugene Bell | Tissue equivalent test systems |
US4837379A (en) * | 1988-06-02 | 1989-06-06 | Organogenesis Inc. | Fibrin-collagen tissue equivalents and methods for preparation thereof |
US4996154A (en) * | 1989-05-04 | 1991-02-26 | Millipore Corporation | Method for growing cellular tissue |
US4912057A (en) * | 1989-06-13 | 1990-03-27 | Cancer Diagnostics, Inc. | Cell chamber for chemotaxis assay |
-
1990
- 1990-08-20 IL IL95429A patent/IL95429A/en not_active IP Right Cessation
- 1990-08-24 CA CA002298856A patent/CA2298856C/en not_active Expired - Fee Related
- 1990-08-24 CA CA002023968A patent/CA2023968C/en not_active Expired - Fee Related
- 1990-09-05 AU AU62156/90A patent/AU6215690A/en not_active Abandoned
- 1990-09-11 DK DK90309942.2T patent/DK0418035T3/en active
- 1990-09-11 DE DE69017324T patent/DE69017324T2/en not_active Expired - Lifetime
- 1990-09-11 AT AT90309942T patent/ATE119194T1/en not_active IP Right Cessation
- 1990-09-11 EP EP90309942A patent/EP0418035B1/en not_active Expired - Lifetime
- 1990-09-11 ES ES90309942T patent/ES2071778T3/en not_active Expired - Lifetime
- 1990-09-14 IE IE334090A patent/IE903340A1/en not_active IP Right Cessation
- 1990-09-14 KR KR1019900014547A patent/KR940001379B1/en not_active IP Right Cessation
- 1990-09-14 JP JP2246000A patent/JPH03151977A/en active Granted
-
1994
- 1994-02-09 US US08/193,809 patent/US5536656A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
IE903340A1 (en) | 1991-04-10 |
KR910005893A (en) | 1991-04-27 |
CA2298856C (en) | 2004-11-16 |
ES2071778T3 (en) | 1995-07-01 |
IL95429A (en) | 1997-09-30 |
ATE119194T1 (en) | 1995-03-15 |
DE69017324T2 (en) | 1995-08-03 |
DK0418035T3 (en) | 1995-07-10 |
DE69017324D1 (en) | 1995-04-06 |
CA2298856A1 (en) | 1991-03-16 |
AU6215690A (en) | 1991-08-01 |
KR940001379B1 (en) | 1994-02-21 |
EP0418035A1 (en) | 1991-03-20 |
EP0418035B1 (en) | 1995-03-01 |
JPH03151977A (en) | 1991-06-28 |
CA2023968C (en) | 2000-05-02 |
US5536656A (en) | 1996-07-16 |
IL95429A0 (en) | 1991-06-30 |
JPH0553505B2 (en) | 1993-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2023968A1 (en) | Living tissue equivalents | |
GB2213381B (en) | Surgical diathermy instruments | |
GR3021312T3 (en) | Collagen constructs | |
AU1932488A (en) | Surgical suturing apparatus | |
AU1726888A (en) | Bone/tissue analyzer and method | |
AU1508588A (en) | An apparatus for the treatment of biological samples and treatment methods using the same | |
AU1753388A (en) | Method and apparatus for testing or exercising muscles of the lower trunk of the human body | |
FR2655840B1 (en) | SURGICAL SET OF LIGAMENTOPLASTY AND CONSTITUENT ELEMENTS. | |
AU2744888A (en) | Medical instrument | |
AU5586590A (en) | Medical instrument location means | |
AU633965B2 (en) | Test instrument | |
AU634582B2 (en) | Combined surgical needle-suture device and method for its manufacture | |
DE69019886T2 (en) | Catheters and instruments for extracorporeal circulation. | |
GR3031149T3 (en) | Process for the manufacture of (s)-3-amino-1-substituted-pyrrolidines. | |
AU5060690A (en) | Sterilant mixture and sterilization method | |
IL83174A (en) | Surgical and aspirating instruments | |
AU5208090A (en) | Apparatus for sterilisation or incineration of surgical instruments and the like | |
NO903338L (en) | PROCEDURE FOR MICROBIOLOGICAL PREPARATION OF L-CARNITIN. | |
EP0308258A3 (en) | Surgical method and instrument therefor | |
AU8419991A (en) | Blood testing apparatus | |
GR3005231T3 (en) | ||
GB8723476D0 (en) | Surgical instruments | |
AU2629088A (en) | Apparatus for examining the eye by iriscopy and/or irigraphy | |
AU5731490A (en) | Methods and apparatus for the determination of chlorine | |
NO893188L (en) | TISSUE AND PROCEDURE FOR THE PREPARATION OF THIS. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |