CA2027745C - Dual indifferent electrode - Google Patents
Dual indifferent electrodeInfo
- Publication number
- CA2027745C CA2027745C CA002027745A CA2027745A CA2027745C CA 2027745 C CA2027745 C CA 2027745C CA 002027745 A CA002027745 A CA 002027745A CA 2027745 A CA2027745 A CA 2027745A CA 2027745 C CA2027745 C CA 2027745C
- Authority
- CA
- Canada
- Prior art keywords
- signal
- electrode
- pacer
- carrier
- heart
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
- A61N1/36521—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure the parameter being derived from measurement of an electrical impedance
Abstract
An endocardial lead having first and second spaced apart electrodes resides in a patient's heart. The first electrode is a sensing electrode and the second electrode is a carrier signal driving electrode. The lead has a conductor coupling a source of alternating current carrier signals of a predetermined frequency to the second electrode. A third electrode is in electrical contact with body tissues. A cardiac pacer apparatus includes a pacer can which functions as a fourth electrode and has a plastic top wherein the third electrode is located. Said third electrode acts in cooperation with the first electrode to form a pair of sensing electrodes. The sensing electrode pair is further coupled to a sense amplifier for receiving an amplifying modulated electrical signals developed across the sensing electrode pair. A demodulator and filters circuit for demodulating the modulated carrier signal and recovering the modulating signal therefrom is connected to the output of the sense amplifier. The modulating signal is proportional to instantaneous stroke volume of the patient's heart and the demodulator and filters circuit develops a control signal therefrom called a stroke volume signal. The control signal is applied to the pulse generator so as to control the rate of stimulating pulses.
Description
DUAL INDIFFERENT ELECTRODE 2 n 27 7 4 5 FIELD OF THE lNV~NLlON
This invention relates broadly to the art of implantable medical devices and, more particularly, to apparatus having dual indifferent electrodes which allow the implementation of an implanted tetrapolar impedance system that requires only a bipolar pacing lead. Such an apparatus finds use in a tetrapolar impedance system that provides a stroke volume signal and a ventilatory signal using any bipolar pacing lead. In a further aspect, the dual indifferent electrode of the invention also facilitates a tripolar impedance technique using only a unipolar endocardial lead.
BACKGROUND OF THE lNV~NLlON
The stroke volume of the heart has been recognized as providing a useful signal to control the timing circuit of a demand-type cardiac pacer. In such a system, the pacer pulse generator will output stimulating pulses in accordance with the physiologic demand indicated by stroke volume changes in the patient's heart. In U.S. Patent 4,686,987 to Salo, et al, entitled "Biomedical Method and Apparatus for Controlling the Administration of Therapy to a Patient in Response to Changes in Physiologic Demand", a biomedical apparatus capable of sensing changes in the heart's ventricular volume or stroke volume is disclosed. The apparatus changes the operating performance of the device as a function of stroke volume. Salo, et al teaches that a relatively low frequency signal (under 5KHz) is applied between spaced electrodes disposed in the heart. The beating , ~ .
action of the heart serves to modulate the signal due to changes in impedance being sensed between these or other electrodes within the heart. The modulated carrier signal is processed to remove R-Wave and other electrical artifacts and then demodulated to remove the carrier frequency component, leaving an envelope signal which is proportional to instantaneous ventricular volume.
This envelope signal then contains stroke volume and ventricular volume information which can be used by the biomedical apparatus to vary its operating parameters. For example, a current proportional to changes in the stroke volume may be injected into the timing circuit of a demand-type cardiac pacer pulse generator whereby the interpulse interval of the pulse generator is varied as a function of stroke volume.
It has been recognized that the ventilatory signal also appears as a component of the impedance signal. Because the intrathoracic pressure is directly related to ventilation (i.e.
pressure drops during inspiration and increases during expiration), the amplitude of the variation in intrathoracic pressure during a ventilatory cycle is directly related to the depth of ventilation (i.e. respiration). U.S. Patent 5,137,019 provides an impedance system for measurement of right ventricular (or atrial) volume or a pressure transducer for measurement of right ventricular (or atrial) pressure, a signal processing means to extract one of the volume or pressure parameters on a beat-by-beat basis to thereby yield a signal varying at the ventilatory rate and with a peak-to-peak amplitude proportional to ventilatory depth.
Referring again to the Salo, et al patent, for example, a 2~ ~7~
cardiac lead having two sensing electrodes and a stimulating electrode is used. Often, in the case of a cardiac pacer replacement, a bipolar lead having only two electrodes has previously been implanted in the heart. In such cases, since it is desirable to use the already implanted lead with a new pacemaker system in the case of, for example, replacing a worn-out pacemaker, the three electrode lead as used by Salo, et al. is often not available. In such cases, only three electrodes are typically available, namely, the pulse generator case or can, a lead ring on the endocardial lead and a tip electrode on the endocardial lead.
Prior approaches to implementing an intracardiac impedance system with only three electrodes available have used at least one electrode as a simultaneous drive and sense electrode, since two drive and two sense points are required. Such approaches have several disadvantages.
One disadvantage of prior art techniques results from a high current density region being sensed at the "common" electrode (i.e., the electrode being used as both a drive and sense electrode) making it very sensitive to local effects such as, for example, mechanical motion. Another disadvantage of prior art systems results from the interface impedance at the common electrode which presents a large DC offset when sensed, yielding a lower modulation index relative to that experienced with tetrapolar impedance. Yet another drawback of prior art systems is that if the common electrode is on the pacemaker lead, either the ring or the tip, system performance will vary as a function of electrode material, effective surface area, geometry and various other elec~rode characteristics.
The method of the present invention uses tetrapolar impedance techniques and overcomes the above described disadvantages of prior 2 Q 2 ~ 7 4 ~
art devices. Since the present invention effectively implements a tetrapolar impedance system that provides a stroke volume signal using any bipolar pacing lead, the quality of the sensed stroke volume signal equals that of a tetrapolar system using a pulse generator can and a tripolar pacing lead. In a further aspect, the signal sensed with the present invention contains a lower frequency component due to ventilation. This component may be extracted as it is related to tidal volume and may be used as another rate controlling parameter.
The present invention also affords an advantage even when used on a unipolar pacing lead. Although a tetrapolar method is not possible for intra-cardiac use in such a case, the dual indifferent method provided by the invention allows a tripolar technique. This has the advantages of reduced motion artifact at the pacer can, as well as a lower DC offset.
~UMMARY OF THE lNv~N~lON
This invention provides apparatus for use in a variable rate pacer apparatus responsive to the metabolic needs of the patient.
In carrying out the instant invention, an endocardial lead having first and second spaced apart electrodes resides in a patient's heart. The first electrode is a sensing electrode and the second electrode is a carrier signal driving electrode. The lead has conductors coupling a source of alternating current carrier signals of a predetermined frequency to the second electrode. A third electrode is in electrical contact with body tissues. The pacer can functions as a fourth electrode and has a plastic top wherein the third electrode is located. The pacer can is coupled to the carrier signals and acts in cooperation with the second electrode to fdrm a pair of driving electrodes. The first electrode and the third electrode form a sensing electrode pair. The sensing ~'7~
electrode pair is coupled to a sense amplifier means for receiving and amplifying modulated electrical signals developed across the sensing electrode pair. A demodulator and filters circuit means for demodulating the modulated carrier signal and recovering the modulating signal therefrom is connected to the output of the sense amplifier means. The modulating signal contains components proportional to instantaneous stroke volume of the patient's heart and the patient's ventilatory tidal volume, and the demodulator and filters circuit develops control signals therefrom called stroke volume and ventilation signals respectively. The control signals are applied to the pulse generator so as to control the rate of stimulating pulses.
It is one object of the invention to provide an implanted tetrapolar impedance system that requires only a bipolar endocardial lead.
It is another object of the invention to provide an implanted tripolar impedance system that requires only a unipolar endocardial lead.
It is yet another advantage of the invention to provide a button electrode electrically isolated from a pacemaker can having a surface area on the same order as that for a lead ring in an endocardial lead.
It is yet another object of the invention to provide an effective implementation of a tetrapolar impedance system that provides a stroke volume signal using any bipolar pacing lead wherein the quality and pulsatile morphology of the signal equals that of a tetrapolar system using a pulse generator can and a tripolar pacing lead as electrodes.
iIt is yet another object of the invention to provide an effective implementation of a tetrapolar impedance system that 202774~
provides a ventilation signal free from can motion artifact using any bipolar pacing lead.
Other objects, features and advantages of the invention will become apparent to those skilled in the art through the description, claims and drawings herein.
Figure 1 schematically shows a pacer apparatus having a dual indifferent electrode apparatus.
Figure 2 schematically shows one embodiment of a dual indifferent electrical apparatus for use in an implantable heart pacemaker in accordance with the invention.
Figure 3 schematically shows an alternate embodiment of a dual indifferent electrode apparatus as employed with a unipolar endocardial lead.
Referring to Figure l there is shown a pacemaker apparatus 2 comprised of a can 10 and a top 11. Mounted in the top 11 and isolated from the metal can 10 is a button electrode 12. Contained within the can lO is electronic circuit 100 which is explained in more detail below and which comprises the dual indifferent electrode circuitry.
Now referring to Figure 2, the circuit 100 is shown in more detail. The can 10 is connected by lead 24 to an oscillator 22 which serves as a carrier current source. An endocardial lead 40 is connected to a pulse generator 44 which is contained within the pacemaker 2. The lead 40 includes electrodes 28 and 30 located within one of the chambers of the heart 50. Electrode 30 may be, for example, a tip electrode on a catheter type lead while electrode 28 may be, for example, a ring electrode. Insulator 42 mechanically connects electrodes 28 and 30. The oscillator 22 is arranged to produce an alternating current carrier signal at a frequency which is quite high compared to the heart rate.
Typically the carrier signal is in the range of from about 500 to 20000 Hz. The carrier signal is driven by electrode 30 through body tissues to the can 10. Button electrode 12 has a surface area typically on the same order of magnitude as the surface area of ring electrode 28 and is advantageously disposed on the plastic top 11 of the implantable pacemaker 2. The button electrode 12 is connected via lead 34 to a first input of a differential amplifier 14. Ring electrode 28 is also connected via lead 32 to a second input of differential amplifier 14. The output of differential amplifier 14 is carried via conductor 16 into demodulator and filters circuit 18. The demodulator and filters circuit 18 is connected by line 20 to the pulse generator. The demodulator and filters circuit 18 may include signal processing circuits as are shown in U.S. Patent 4,686,987, as well as filtering means to separate the higher frequency stroke volume signal from the lower frequency ventilation signal.
In operation, the pulse generator 44 provides stimulating pulses to stimulating electrodes in a well known manner to pace the heart. Electrodes 28 and 12 sense stroke volume impedance signals or other physiological signals of interest. The signals are fed into the differential amplifier 14 which provides a differential signal to the demodulator and filters circuit 18.
The demodulator and filters circuit includes means for demodulating the modulating carrier signal and recovering the modulating signal therefrom. The modulating signal contains " :;, frequency components proportional to the instantaneous stroke volume of the patient's heart and to the instantaneous tidal volume of the patient's ventilation. The -7a-2Q2'~7~
demodulator and filters circuit 18 then provides control signals, SV SIGNAL 20 and VENT SIGNAL 21 to the pulse generator. The pulse generator responds to the control signal by determining a rate at which the heart stimulating pulses will be generated.
Now referring to Figure 3, an alternate embodiment of the invention is shown as employed with a unipolar endocardial lead.
In this embodiment, it will be understood that circuit lOOA is similar to circuit loO except that it is modified to accomodate unipolar pacing and sensing techniques. In this embodiment, the can 10 is connected by lead 24 to the oscillator 22 which serves as a carrier current source. The endocardial lead 4OA is connected to a pulse generator 44 which is contained within the pacemaker 2.
Lead 45 connects the pulse generator to the can 10 which, in this case, serves as a stimulating electrode. The lead 40A includes electrode 30 located within one of the chambers of the heart 50.
Electrode 30 may be, for example, a tip electrode on a catheter type lead. The oscillator 22 is arranged to produce an alternating current carrier signal at a frequency which is quite high compared to the heart rate. Typically the carrier signal is in the range of from about 500 to 20000 Hz. The carrier signal is driven by electrode 30 through body tissues to the can 10. Button electrode 12 has a surface area typically on the same order of magnitude as the surface area of electrode 30 and is advantageously disposed on the plastic top 11 of the implantable pacemaker 2. The button electrode 12 is connected via lead 34 to a first input of a differential amplifier 14. Tip electrode 30 is also connected via lead 32A to a second input of differential amplifier 14. The output of differential amplifier 14 is carried via conductor 16 into demodulator and filters circuit 18. The demodulator and filters circuit 18 are connected by lines 20 and 21 to the pulse 2~2 ~74~
.
generator. The circuit 18 is configured as described above with reference to Figure 2.
In operation, the pulse generator 44 provides stimulating pulses to stimulating electrodes in a well known manner to pace the heart. Electrodes 30 and 12 sense stroke volume impedance signals or other physiological signals of interest. The signals are fed into the differential amplifier 14 which provides a differential signal to the circuit 18. The demodulator and filters circuit operates as described above with reference to Figure 2.
lo The invention has been described herein in considerable detail in order to comply with the patent statutes and to provide those skilled in the art with information needed to apply the novel principles and to construct and use such specialized components as are required. However, it is to be understood that the invention can be carried out by specifically different equipment and devices.
For example, the control signal proportional to stroke volume change may be used in conjunction with an implantable infusion pump for administering such drugs as dobutamine, isoproterenol or nitroprusside whereby stroke volume may be maintained at a desired value. Alternatively, the demodulated waveform or control signal may be used directly by other diagnostic equipment. By appropriately utilizing the information derived from the ventricular impedance, it would be possible to measure stroke volume without having to resort to thermal dilution or other techniques. Hence, various modifications, both as to the equipment details and operating procedures can be effective without departing from the scope of the invention itself.
What is claimed is:
This invention relates broadly to the art of implantable medical devices and, more particularly, to apparatus having dual indifferent electrodes which allow the implementation of an implanted tetrapolar impedance system that requires only a bipolar pacing lead. Such an apparatus finds use in a tetrapolar impedance system that provides a stroke volume signal and a ventilatory signal using any bipolar pacing lead. In a further aspect, the dual indifferent electrode of the invention also facilitates a tripolar impedance technique using only a unipolar endocardial lead.
BACKGROUND OF THE lNV~NLlON
The stroke volume of the heart has been recognized as providing a useful signal to control the timing circuit of a demand-type cardiac pacer. In such a system, the pacer pulse generator will output stimulating pulses in accordance with the physiologic demand indicated by stroke volume changes in the patient's heart. In U.S. Patent 4,686,987 to Salo, et al, entitled "Biomedical Method and Apparatus for Controlling the Administration of Therapy to a Patient in Response to Changes in Physiologic Demand", a biomedical apparatus capable of sensing changes in the heart's ventricular volume or stroke volume is disclosed. The apparatus changes the operating performance of the device as a function of stroke volume. Salo, et al teaches that a relatively low frequency signal (under 5KHz) is applied between spaced electrodes disposed in the heart. The beating , ~ .
action of the heart serves to modulate the signal due to changes in impedance being sensed between these or other electrodes within the heart. The modulated carrier signal is processed to remove R-Wave and other electrical artifacts and then demodulated to remove the carrier frequency component, leaving an envelope signal which is proportional to instantaneous ventricular volume.
This envelope signal then contains stroke volume and ventricular volume information which can be used by the biomedical apparatus to vary its operating parameters. For example, a current proportional to changes in the stroke volume may be injected into the timing circuit of a demand-type cardiac pacer pulse generator whereby the interpulse interval of the pulse generator is varied as a function of stroke volume.
It has been recognized that the ventilatory signal also appears as a component of the impedance signal. Because the intrathoracic pressure is directly related to ventilation (i.e.
pressure drops during inspiration and increases during expiration), the amplitude of the variation in intrathoracic pressure during a ventilatory cycle is directly related to the depth of ventilation (i.e. respiration). U.S. Patent 5,137,019 provides an impedance system for measurement of right ventricular (or atrial) volume or a pressure transducer for measurement of right ventricular (or atrial) pressure, a signal processing means to extract one of the volume or pressure parameters on a beat-by-beat basis to thereby yield a signal varying at the ventilatory rate and with a peak-to-peak amplitude proportional to ventilatory depth.
Referring again to the Salo, et al patent, for example, a 2~ ~7~
cardiac lead having two sensing electrodes and a stimulating electrode is used. Often, in the case of a cardiac pacer replacement, a bipolar lead having only two electrodes has previously been implanted in the heart. In such cases, since it is desirable to use the already implanted lead with a new pacemaker system in the case of, for example, replacing a worn-out pacemaker, the three electrode lead as used by Salo, et al. is often not available. In such cases, only three electrodes are typically available, namely, the pulse generator case or can, a lead ring on the endocardial lead and a tip electrode on the endocardial lead.
Prior approaches to implementing an intracardiac impedance system with only three electrodes available have used at least one electrode as a simultaneous drive and sense electrode, since two drive and two sense points are required. Such approaches have several disadvantages.
One disadvantage of prior art techniques results from a high current density region being sensed at the "common" electrode (i.e., the electrode being used as both a drive and sense electrode) making it very sensitive to local effects such as, for example, mechanical motion. Another disadvantage of prior art systems results from the interface impedance at the common electrode which presents a large DC offset when sensed, yielding a lower modulation index relative to that experienced with tetrapolar impedance. Yet another drawback of prior art systems is that if the common electrode is on the pacemaker lead, either the ring or the tip, system performance will vary as a function of electrode material, effective surface area, geometry and various other elec~rode characteristics.
The method of the present invention uses tetrapolar impedance techniques and overcomes the above described disadvantages of prior 2 Q 2 ~ 7 4 ~
art devices. Since the present invention effectively implements a tetrapolar impedance system that provides a stroke volume signal using any bipolar pacing lead, the quality of the sensed stroke volume signal equals that of a tetrapolar system using a pulse generator can and a tripolar pacing lead. In a further aspect, the signal sensed with the present invention contains a lower frequency component due to ventilation. This component may be extracted as it is related to tidal volume and may be used as another rate controlling parameter.
The present invention also affords an advantage even when used on a unipolar pacing lead. Although a tetrapolar method is not possible for intra-cardiac use in such a case, the dual indifferent method provided by the invention allows a tripolar technique. This has the advantages of reduced motion artifact at the pacer can, as well as a lower DC offset.
~UMMARY OF THE lNv~N~lON
This invention provides apparatus for use in a variable rate pacer apparatus responsive to the metabolic needs of the patient.
In carrying out the instant invention, an endocardial lead having first and second spaced apart electrodes resides in a patient's heart. The first electrode is a sensing electrode and the second electrode is a carrier signal driving electrode. The lead has conductors coupling a source of alternating current carrier signals of a predetermined frequency to the second electrode. A third electrode is in electrical contact with body tissues. The pacer can functions as a fourth electrode and has a plastic top wherein the third electrode is located. The pacer can is coupled to the carrier signals and acts in cooperation with the second electrode to fdrm a pair of driving electrodes. The first electrode and the third electrode form a sensing electrode pair. The sensing ~'7~
electrode pair is coupled to a sense amplifier means for receiving and amplifying modulated electrical signals developed across the sensing electrode pair. A demodulator and filters circuit means for demodulating the modulated carrier signal and recovering the modulating signal therefrom is connected to the output of the sense amplifier means. The modulating signal contains components proportional to instantaneous stroke volume of the patient's heart and the patient's ventilatory tidal volume, and the demodulator and filters circuit develops control signals therefrom called stroke volume and ventilation signals respectively. The control signals are applied to the pulse generator so as to control the rate of stimulating pulses.
It is one object of the invention to provide an implanted tetrapolar impedance system that requires only a bipolar endocardial lead.
It is another object of the invention to provide an implanted tripolar impedance system that requires only a unipolar endocardial lead.
It is yet another advantage of the invention to provide a button electrode electrically isolated from a pacemaker can having a surface area on the same order as that for a lead ring in an endocardial lead.
It is yet another object of the invention to provide an effective implementation of a tetrapolar impedance system that provides a stroke volume signal using any bipolar pacing lead wherein the quality and pulsatile morphology of the signal equals that of a tetrapolar system using a pulse generator can and a tripolar pacing lead as electrodes.
iIt is yet another object of the invention to provide an effective implementation of a tetrapolar impedance system that 202774~
provides a ventilation signal free from can motion artifact using any bipolar pacing lead.
Other objects, features and advantages of the invention will become apparent to those skilled in the art through the description, claims and drawings herein.
Figure 1 schematically shows a pacer apparatus having a dual indifferent electrode apparatus.
Figure 2 schematically shows one embodiment of a dual indifferent electrical apparatus for use in an implantable heart pacemaker in accordance with the invention.
Figure 3 schematically shows an alternate embodiment of a dual indifferent electrode apparatus as employed with a unipolar endocardial lead.
Referring to Figure l there is shown a pacemaker apparatus 2 comprised of a can 10 and a top 11. Mounted in the top 11 and isolated from the metal can 10 is a button electrode 12. Contained within the can lO is electronic circuit 100 which is explained in more detail below and which comprises the dual indifferent electrode circuitry.
Now referring to Figure 2, the circuit 100 is shown in more detail. The can 10 is connected by lead 24 to an oscillator 22 which serves as a carrier current source. An endocardial lead 40 is connected to a pulse generator 44 which is contained within the pacemaker 2. The lead 40 includes electrodes 28 and 30 located within one of the chambers of the heart 50. Electrode 30 may be, for example, a tip electrode on a catheter type lead while electrode 28 may be, for example, a ring electrode. Insulator 42 mechanically connects electrodes 28 and 30. The oscillator 22 is arranged to produce an alternating current carrier signal at a frequency which is quite high compared to the heart rate.
Typically the carrier signal is in the range of from about 500 to 20000 Hz. The carrier signal is driven by electrode 30 through body tissues to the can 10. Button electrode 12 has a surface area typically on the same order of magnitude as the surface area of ring electrode 28 and is advantageously disposed on the plastic top 11 of the implantable pacemaker 2. The button electrode 12 is connected via lead 34 to a first input of a differential amplifier 14. Ring electrode 28 is also connected via lead 32 to a second input of differential amplifier 14. The output of differential amplifier 14 is carried via conductor 16 into demodulator and filters circuit 18. The demodulator and filters circuit 18 is connected by line 20 to the pulse generator. The demodulator and filters circuit 18 may include signal processing circuits as are shown in U.S. Patent 4,686,987, as well as filtering means to separate the higher frequency stroke volume signal from the lower frequency ventilation signal.
In operation, the pulse generator 44 provides stimulating pulses to stimulating electrodes in a well known manner to pace the heart. Electrodes 28 and 12 sense stroke volume impedance signals or other physiological signals of interest. The signals are fed into the differential amplifier 14 which provides a differential signal to the demodulator and filters circuit 18.
The demodulator and filters circuit includes means for demodulating the modulating carrier signal and recovering the modulating signal therefrom. The modulating signal contains " :;, frequency components proportional to the instantaneous stroke volume of the patient's heart and to the instantaneous tidal volume of the patient's ventilation. The -7a-2Q2'~7~
demodulator and filters circuit 18 then provides control signals, SV SIGNAL 20 and VENT SIGNAL 21 to the pulse generator. The pulse generator responds to the control signal by determining a rate at which the heart stimulating pulses will be generated.
Now referring to Figure 3, an alternate embodiment of the invention is shown as employed with a unipolar endocardial lead.
In this embodiment, it will be understood that circuit lOOA is similar to circuit loO except that it is modified to accomodate unipolar pacing and sensing techniques. In this embodiment, the can 10 is connected by lead 24 to the oscillator 22 which serves as a carrier current source. The endocardial lead 4OA is connected to a pulse generator 44 which is contained within the pacemaker 2.
Lead 45 connects the pulse generator to the can 10 which, in this case, serves as a stimulating electrode. The lead 40A includes electrode 30 located within one of the chambers of the heart 50.
Electrode 30 may be, for example, a tip electrode on a catheter type lead. The oscillator 22 is arranged to produce an alternating current carrier signal at a frequency which is quite high compared to the heart rate. Typically the carrier signal is in the range of from about 500 to 20000 Hz. The carrier signal is driven by electrode 30 through body tissues to the can 10. Button electrode 12 has a surface area typically on the same order of magnitude as the surface area of electrode 30 and is advantageously disposed on the plastic top 11 of the implantable pacemaker 2. The button electrode 12 is connected via lead 34 to a first input of a differential amplifier 14. Tip electrode 30 is also connected via lead 32A to a second input of differential amplifier 14. The output of differential amplifier 14 is carried via conductor 16 into demodulator and filters circuit 18. The demodulator and filters circuit 18 are connected by lines 20 and 21 to the pulse 2~2 ~74~
.
generator. The circuit 18 is configured as described above with reference to Figure 2.
In operation, the pulse generator 44 provides stimulating pulses to stimulating electrodes in a well known manner to pace the heart. Electrodes 30 and 12 sense stroke volume impedance signals or other physiological signals of interest. The signals are fed into the differential amplifier 14 which provides a differential signal to the circuit 18. The demodulator and filters circuit operates as described above with reference to Figure 2.
lo The invention has been described herein in considerable detail in order to comply with the patent statutes and to provide those skilled in the art with information needed to apply the novel principles and to construct and use such specialized components as are required. However, it is to be understood that the invention can be carried out by specifically different equipment and devices.
For example, the control signal proportional to stroke volume change may be used in conjunction with an implantable infusion pump for administering such drugs as dobutamine, isoproterenol or nitroprusside whereby stroke volume may be maintained at a desired value. Alternatively, the demodulated waveform or control signal may be used directly by other diagnostic equipment. By appropriately utilizing the information derived from the ventricular impedance, it would be possible to measure stroke volume without having to resort to thermal dilution or other techniques. Hence, various modifications, both as to the equipment details and operating procedures can be effective without departing from the scope of the invention itself.
What is claimed is:
Claims (17)
1. A variable rate cardiac pacer apparatus responsive to metabolic needs of the patient, wherein the cardiac pacer apparatus includes a pulse generator, comprising:
(a) a source of alternating current carrier signals of a predetermined frequency;
(b) a pacer can wherein the pacer can is coupled to the source of carrier signals;
(c) an endocardial lead having at least first and second electrodes wherein the second electrode is connected to the source of carrier signals so as to operate as a driver of the carrier signals;
(d) a third electrode insulated from the pacer can, in electrical contact with body tissues and structured and arranged to cooperate with the first electrode to form a pair of sensing electrodes;
(e) sense amplifier means coupling to the pair of sensing electrodes for receiving and amplifying modulated electrical signals developed across the sensing electrodes;
(f) demodulator and filters circuit means for demodulating said modulated carrier signal and recovering the modulating signal therefrom, said modulating signal being proportional to instantaneous stroke volume of the patient's heart wherein the demodulator and filters circuit develops a control signal consistent with the instantaneous stroke volume; and (g) means applying said control signal to the pulse generator.
(a) a source of alternating current carrier signals of a predetermined frequency;
(b) a pacer can wherein the pacer can is coupled to the source of carrier signals;
(c) an endocardial lead having at least first and second electrodes wherein the second electrode is connected to the source of carrier signals so as to operate as a driver of the carrier signals;
(d) a third electrode insulated from the pacer can, in electrical contact with body tissues and structured and arranged to cooperate with the first electrode to form a pair of sensing electrodes;
(e) sense amplifier means coupling to the pair of sensing electrodes for receiving and amplifying modulated electrical signals developed across the sensing electrodes;
(f) demodulator and filters circuit means for demodulating said modulated carrier signal and recovering the modulating signal therefrom, said modulating signal being proportional to instantaneous stroke volume of the patient's heart wherein the demodulator and filters circuit develops a control signal consistent with the instantaneous stroke volume; and (g) means applying said control signal to the pulse generator.
2. The apparatus of Claim 1 wherein the modulating signal includes a ventilatory signal component, and following demodulation the ventilatory signal component is recovered, and said signal, being proportional to instantaneous ventilation, is used to develop a heart rate control signal consistent with either instantaneous or time averaged ventilation.
3. The apparatus of Claim 1 wherein the pacer apparatus includes an insulated top and the third electrode resides exposed through the insulated top.
4. The apparatus of Claim 1 wherein the predetermined carrier signal frequency is in a range from about 500 to 20,000 Hertz.
5. In a variable rate cardiac pacer apparatus responsive to metabolic needs of the patient and including a conductive pacer can having an insulating member, a source of alternating current carrier signals of a predetermined frequency, wherein the pacer can is connected to the carrier signal source, and a pulse generator means for determining the rate at which heart stimulating pulses will be generated, the improvement comprising:
(a) an endocardial lead having first and second electrodes wherein the second electrode is connected to the carrier signal source and operates as a driver for the carrier signal;
(b) a third electrode disposed on the insulating member wherein the first and third electrodes are structured and arranged to operate as a pair of sensing electrodes;
(c) sense amplifier means coupling to the pair of sensing electrodes for receiving and amplifying modulated signals developed across the sensing electrodes;
(d) demodulator and filters circuit means for demodulating the amplified modulated carrier signal and recovering the modulating signal therefrom, the modulating signal being proportional to instantaneous stroke volume of the patient's heart wherein the demodulator and filters circuit develops a control signal therefrom; and (e) means coupling the control signal to the pulse generator wherein the pulse generator operates to output stimulating pulses at a rate consistent with the control signal.
(a) an endocardial lead having first and second electrodes wherein the second electrode is connected to the carrier signal source and operates as a driver for the carrier signal;
(b) a third electrode disposed on the insulating member wherein the first and third electrodes are structured and arranged to operate as a pair of sensing electrodes;
(c) sense amplifier means coupling to the pair of sensing electrodes for receiving and amplifying modulated signals developed across the sensing electrodes;
(d) demodulator and filters circuit means for demodulating the amplified modulated carrier signal and recovering the modulating signal therefrom, the modulating signal being proportional to instantaneous stroke volume of the patient's heart wherein the demodulator and filters circuit develops a control signal therefrom; and (e) means coupling the control signal to the pulse generator wherein the pulse generator operates to output stimulating pulses at a rate consistent with the control signal.
6. The apparatus of Claim 5 wherein the carrier signals have a frequency in the range of about 500 to 20,000 Hertz.
7. The apparatus of Claim 1 wherein both the stroke volume signal and ventilatory signal are recovered after demodulation and used as inputs to a heart rate control mechanism.
8. A variable rate cardiac pacer apparatus responsive to metabolic needs of the patient, wherein the cardiac pacer apparatus includes a pulse generator, comprising:
(a) a source of alternating current carrier signals of a predetermined frequency;
(b) a pacer can wherein the pacer can is coupled to the source of carrier signals;
(c) a unipolar lead having a first electrode wherein the first electrode is connected to the source of carrier signals so as to operate as a driver of the carrier signals;
(d) a second electrode insulated from the pacer can, in electrical contact with body tissues and structured and arranged to cooperate with the first electrode to form a pair of sensing electrodes;
(e) sense amplifier means coupling to the pair of sensing electrodes for receiving and amplifying modulated electrical signals developed across the sensing electrodes;
(f) demodulator and filters circuit means for demodulating said modulated carrier signal and recovering the modulating signal therefrom, said modulating signal being proportional to instantaneous stroke volume of the patient's heart wherein the demodulator and filters circuit develops a control signal consistent with the instantaneous stroke volume; and (g) means applying said control signal to the pulse generator.
(a) a source of alternating current carrier signals of a predetermined frequency;
(b) a pacer can wherein the pacer can is coupled to the source of carrier signals;
(c) a unipolar lead having a first electrode wherein the first electrode is connected to the source of carrier signals so as to operate as a driver of the carrier signals;
(d) a second electrode insulated from the pacer can, in electrical contact with body tissues and structured and arranged to cooperate with the first electrode to form a pair of sensing electrodes;
(e) sense amplifier means coupling to the pair of sensing electrodes for receiving and amplifying modulated electrical signals developed across the sensing electrodes;
(f) demodulator and filters circuit means for demodulating said modulated carrier signal and recovering the modulating signal therefrom, said modulating signal being proportional to instantaneous stroke volume of the patient's heart wherein the demodulator and filters circuit develops a control signal consistent with the instantaneous stroke volume; and (g) means applying said control signal to the pulse generator.
9. The apparatus of Claim 8 wherein the modulating signal includes a ventilatory signal component, and following demodulation the ventilatory signal component is recovered, and said signal, being proportional to instantaneous ventilation, is used to develop a heart rate control signal consistent with at least one of instantaneous and time averaged ventilation.
10. The apparatus of Claim 8 wherein the pacer apparatus includes an insulated top and the second electrode resides exposed through the insulated top.
11. The apparatus of Claim 8 wherein the predetermined carrier signal frequency is in a range from about 500 to 20,000 Hertz.
12. In a variable rate cardiac pacer apparatus responsive to metabolic needs of the patient and including a conductive pacer can having an insulating member, a source of alternating current carrier signals of a predetermined frequency, wherein the pacer can is connected to the carrier signal source, and a pulse generator means for determining the rate at which heart
13 stimulating pulses will be generated, the improvement comprising:
(a) a unipolar endocardial lead having a first electrode connected to the carrier signal source so as to operate as a driver for the carrier signal;
(b) a second electrode disposed on the insulating member wherein the first and second electrodes are structured and arranged to operate as a pair of sensing electrodes;
(c) sense amplifier means coupling to the pair of sensing electrodes for receiving and amplifying modulated signals developed across the sensing electrodes;
(d) demodulator and filters circuit means for demodulating the amplified modulated carrier signal and recovering the modulating signal therefrom, the modulating signal being proportional to instantaneous stroke volume of the patient's heart wherein the demodulator and filters circuit develops a control signal therefrom; and (e) means coupling the control signal to the pulse generator wherein the pulse generator operates to output stimulating pulses at a rate consistent with the control signal.
13. The apparatus of Claim 12 wherein the carrier signals have a frequency in the range of about 500 to 20,000 Hertz.
(a) a unipolar endocardial lead having a first electrode connected to the carrier signal source so as to operate as a driver for the carrier signal;
(b) a second electrode disposed on the insulating member wherein the first and second electrodes are structured and arranged to operate as a pair of sensing electrodes;
(c) sense amplifier means coupling to the pair of sensing electrodes for receiving and amplifying modulated signals developed across the sensing electrodes;
(d) demodulator and filters circuit means for demodulating the amplified modulated carrier signal and recovering the modulating signal therefrom, the modulating signal being proportional to instantaneous stroke volume of the patient's heart wherein the demodulator and filters circuit develops a control signal therefrom; and (e) means coupling the control signal to the pulse generator wherein the pulse generator operates to output stimulating pulses at a rate consistent with the control signal.
13. The apparatus of Claim 12 wherein the carrier signals have a frequency in the range of about 500 to 20,000 Hertz.
14. The apparatus of Claim 8 wherein both the stroke volume signal and ventilatory signal are recovered after demodulation and are used as inputs to a heart rate control mechanism.
15. The apparatus of Claim 12 wherein both the stroke volume signal and ventilatory signal are recovered after demodulation and are used as inputs to a heart rate control mechanism.
16. The apparatus of Claim 5 wherein both the stroke volume signal and ventilatory signal are recovered after demodulation and are used as inputs to a heart rate control mechanism.
17. In a variable rate cardiac pacer apparatus responsive to metabolic needs of the patient and including a conductive pacer can having an insulating member, a source of alternating current carrier signals of a predetermined frequency, wherein the pacer can is connected to the carrier signal source, a pulse generator means for determining the rate at which heart stimulating pulses will be generated and an endocardial lead having a first electrode wherein the first electrode is connected to the carrier signal source and operates as a driver for the carrier signal, the improvement comprising a second electrode disposed on the insulating member wherein the first and second electrodes are structured and arranged to operate as a pair of sensing electrodes.
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US07/503,991 | 1990-04-04 | ||
US07/503,991 US5036849A (en) | 1990-04-04 | 1990-04-04 | Variable rate cardiac pacer |
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CA2027745A1 CA2027745A1 (en) | 1991-10-05 |
CA2027745C true CA2027745C (en) | 1998-07-07 |
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CA002027745A Expired - Fee Related CA2027745C (en) | 1990-04-04 | 1990-10-16 | Dual indifferent electrode |
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-
1990
- 1990-04-04 US US07/503,991 patent/US5036849A/en not_active Expired - Lifetime
- 1990-10-16 CA CA002027745A patent/CA2027745C/en not_active Expired - Fee Related
- 1990-11-01 DE DE69022029T patent/DE69022029T2/en not_active Expired - Fee Related
- 1990-11-01 EP EP90311987A patent/EP0450229B1/en not_active Expired - Lifetime
- 1990-11-30 JP JP2337034A patent/JP2729104B2/en not_active Expired - Lifetime
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EP0450229A3 (en) | 1992-07-08 |
EP0450229A2 (en) | 1991-10-09 |
JP2729104B2 (en) | 1998-03-18 |
DE69022029D1 (en) | 1995-10-05 |
US5036849A (en) | 1991-08-06 |
CA2027745A1 (en) | 1991-10-05 |
DE69022029T2 (en) | 1996-02-29 |
JPH03289970A (en) | 1991-12-19 |
EP0450229B1 (en) | 1995-08-30 |
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