CA2030829C - Insect repellent plastic - Google Patents
Insect repellent plasticInfo
- Publication number
- CA2030829C CA2030829C CA002030829A CA2030829A CA2030829C CA 2030829 C CA2030829 C CA 2030829C CA 002030829 A CA002030829 A CA 002030829A CA 2030829 A CA2030829 A CA 2030829A CA 2030829 C CA2030829 C CA 2030829C
- Authority
- CA
- Canada
- Prior art keywords
- composition
- repellent
- polymer
- particles
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
Abstract
A composition which is an unexpanded plastic resinous material having uniformly dispersed and incorporated therein discrete particles of a highly cross-linked macroporous hydrophobic polymer. The polymer has entrapped therein a chemical which is a repellent for insects. The chemical is compatible with the unexpanded plastic resinous material. Also disclosed is an article of manufacture and the article is preferably an outdoor accessory such as an item of lawn furniture. However, any article of manufacture which is desired to release a repellent for the purpose of inhibiting or eradicating the collection and swarming of insects would be appropriate in accordance with the invention, whether such articles are intended for indoor or outdoor use.
Description
203082~
INSECT REPELLENT PLASTIC
This invention relates to a plastic composition containing a macroporous cross-linked copolymer. More particularly, the invention includes the concept of entrapping an insect repellent in the copolymer and incorporating the copolymer into a plastic.
In accordance with the present invention, copolymer powders are employet in novel processes not believed to be taught in the prior art which, in general, relates to suspension polymerization processes for the production of porous polymeric and copolymeric spheres and beads in which the precipitant is present during polymerization. These are defined as an "in situ" process.
According to the prior art, crosslinked porous copolymers in particle form can be produced by at least three distinct processes. One process produces beads by "in situ"
suspension polymerization. Another process produces beads by suspension polymerization but the beads are "post adsorbed"
with an active ingredient after the volatile porogen is removed. In a third process, powders are produced by "in situ" precipitation polymerization.
What has been accomplished in accordance with the present invention, however, is a unique concept differing from all of the foregoing methods and wherein post adsorbent powders and beads are produced and used in a novel fashion.
This invention relates to a composition which is an unexpanded plastic resinous material having uniformly dispersed and incorporated therein discrete particles of a highly cross-linked macroporous hydrophobic polymer. The polymer has entrapped therein a chemical which is a repellent -2- ~ - 0 - 2 9 for insects. The chemical is compatible with the unexpanded plastic resinous material.
The unexpanded plastic resinous material is a thermoplastic resin or the unexpanded plastic resinous material can be thermosetting resin. The chemical insect repellent is a compound which repels insects such as mosquitos, ticks, chiggers and cockroaches. In the most preferred embodiment of the present invention, the insect repellent is N,N-diethyl-m-toluamide. The repellent constitutes from about twenty-five to about ninety percent by weight based on the weight of the repellent and the polymer.
More specifically, the repellent constitutes about eighty percent by weight based on the weight of the repellent and the polymer. The repellent and the polymer constitute from about one-half of one percent to about fifty percent by weight based on the weight of the composition.
The invention is also directed to an article manufactured from the above composition and in which the article is an outdoor accessory such as an item of lawn furniture. However, any article of manufacture which is desired to release a repellent for the purpose of inhibiting or eradicating the collection and swarming of insects would be appropriate in accordance with the concepts of the present invention, whether such articles are intended for indoor or outdoor use. Exemplary articles of manufacture would include trash disposal containers, lawn and garden equipment and tools, structural materials for building and residential dwelling houses.
In certain of the more specific embodiments of the present invention, one monomer of the copolymer is a monounsaturated monomer and the monounsaturated monomer is lauryl methacrylate. One monomer of the copolymer can also be a polyunsaturated monomer and the polyunsaturated monomer -3- ~ 9 is selected from the group consisting of ethylene glycol dimethacrylate and tetraethylene glycol dimethacrylate. The polymer can also be formed using only polyunsaturated monomers.
The copolymer is in the form of a powder and the powder is a combined system of particles, the system of particles including unit particles of less than about one micron in average diameter, agglomerates of fused unit particles of sizes in the range of about twenty to eighty microns in average diameter and aggregates of clusters of fused agglomerates of sizes in the range of about two-hundred to about twelve-hundred microns in average diameter. A bead form of the copolymer can also be employed.
A precipitation polymerization process is used for producing the macroporous cross-linked copolymer. In the process, there is copolymerized at least one monounsaturated monomer and at least one polyunsaturated monomer in the presence of an organic liquid which is a solvent for and dissolves the monomers but not the copolymer. The copolymerization of the monomers is initiated by means of a free radical generating catalytic compound, precipitating a copolymer in the solvent in the form of a powder. A dry powder is formed by removing the solvent from the precipitated copolymeric powder.
The solvent is preferably isopropyl alcohol, although ethanol, toluene, heptane, xylene, hexane, ethyl alcohol and cyclohexane may also be employed. The monounsaturated monomer and the polyunsaturated monomer can be present in mol ratios of, for example, 20:80, 30:70, 40:60 or 50:50. The process includes the step of stirring the monomers, solvent and the free radical generating catalytic compound, during copolymerization. Preferably, the dry powder is formed by filtering excess solvent from the r ~
~ -4-precipitated powder and the filtered powder is vacuum dried.
The powder may then be "post adsorbed" with the functional material.
The powders of the present invention may also be used as carriers or adsorbents for various materials such as water, aqueous systems, emollients, moisturizers, fragrances, dyes, pigments, flavors, drugs such as ibuprofen, phosphoric acid, all categories of insect repellents, vitamins, sunscreens, detergents, cosmetics, pesticides, pheromones, herbicides, steroids, sweeteners, pharmaceuticals and antimicrobial agents. Finely divided solids such as analgesic materials can be adsorbed by dissolving the finely divided analgesic in a solvent, mixing the analgesic and solvent with the powder and removing the solvent.
Other post adsorbable materials include alkanes, alcohols, acid esters, silicones, glycols, organic acids, waxes and alcohol ethers.
These and other objects, features and advantages, of the present invention will become apparent when considered in light of the following detailed description, including the accompanying drawings.
Figure 1 in the drawings is a photomicrograph of the various components of the complex structure of the powder produced in Example I and including unit particles, agglomeratures and aggregates.
Figures 2 and 3 are photomicrographs of the agglomerates and a~gregates of Figure 1, respectively, shown on a larger scale.
Figure 4 is a photomicrograph of a polymer bead produced by suspension polymerization.
Figure 5 is a photomicrograph of the bead of Figure 4 with a portion of the shell removed to reveal the interior structure of the bead.
INSECT REPELLENT PLASTIC
This invention relates to a plastic composition containing a macroporous cross-linked copolymer. More particularly, the invention includes the concept of entrapping an insect repellent in the copolymer and incorporating the copolymer into a plastic.
In accordance with the present invention, copolymer powders are employet in novel processes not believed to be taught in the prior art which, in general, relates to suspension polymerization processes for the production of porous polymeric and copolymeric spheres and beads in which the precipitant is present during polymerization. These are defined as an "in situ" process.
According to the prior art, crosslinked porous copolymers in particle form can be produced by at least three distinct processes. One process produces beads by "in situ"
suspension polymerization. Another process produces beads by suspension polymerization but the beads are "post adsorbed"
with an active ingredient after the volatile porogen is removed. In a third process, powders are produced by "in situ" precipitation polymerization.
What has been accomplished in accordance with the present invention, however, is a unique concept differing from all of the foregoing methods and wherein post adsorbent powders and beads are produced and used in a novel fashion.
This invention relates to a composition which is an unexpanded plastic resinous material having uniformly dispersed and incorporated therein discrete particles of a highly cross-linked macroporous hydrophobic polymer. The polymer has entrapped therein a chemical which is a repellent -2- ~ - 0 - 2 9 for insects. The chemical is compatible with the unexpanded plastic resinous material.
The unexpanded plastic resinous material is a thermoplastic resin or the unexpanded plastic resinous material can be thermosetting resin. The chemical insect repellent is a compound which repels insects such as mosquitos, ticks, chiggers and cockroaches. In the most preferred embodiment of the present invention, the insect repellent is N,N-diethyl-m-toluamide. The repellent constitutes from about twenty-five to about ninety percent by weight based on the weight of the repellent and the polymer.
More specifically, the repellent constitutes about eighty percent by weight based on the weight of the repellent and the polymer. The repellent and the polymer constitute from about one-half of one percent to about fifty percent by weight based on the weight of the composition.
The invention is also directed to an article manufactured from the above composition and in which the article is an outdoor accessory such as an item of lawn furniture. However, any article of manufacture which is desired to release a repellent for the purpose of inhibiting or eradicating the collection and swarming of insects would be appropriate in accordance with the concepts of the present invention, whether such articles are intended for indoor or outdoor use. Exemplary articles of manufacture would include trash disposal containers, lawn and garden equipment and tools, structural materials for building and residential dwelling houses.
In certain of the more specific embodiments of the present invention, one monomer of the copolymer is a monounsaturated monomer and the monounsaturated monomer is lauryl methacrylate. One monomer of the copolymer can also be a polyunsaturated monomer and the polyunsaturated monomer -3- ~ 9 is selected from the group consisting of ethylene glycol dimethacrylate and tetraethylene glycol dimethacrylate. The polymer can also be formed using only polyunsaturated monomers.
The copolymer is in the form of a powder and the powder is a combined system of particles, the system of particles including unit particles of less than about one micron in average diameter, agglomerates of fused unit particles of sizes in the range of about twenty to eighty microns in average diameter and aggregates of clusters of fused agglomerates of sizes in the range of about two-hundred to about twelve-hundred microns in average diameter. A bead form of the copolymer can also be employed.
A precipitation polymerization process is used for producing the macroporous cross-linked copolymer. In the process, there is copolymerized at least one monounsaturated monomer and at least one polyunsaturated monomer in the presence of an organic liquid which is a solvent for and dissolves the monomers but not the copolymer. The copolymerization of the monomers is initiated by means of a free radical generating catalytic compound, precipitating a copolymer in the solvent in the form of a powder. A dry powder is formed by removing the solvent from the precipitated copolymeric powder.
The solvent is preferably isopropyl alcohol, although ethanol, toluene, heptane, xylene, hexane, ethyl alcohol and cyclohexane may also be employed. The monounsaturated monomer and the polyunsaturated monomer can be present in mol ratios of, for example, 20:80, 30:70, 40:60 or 50:50. The process includes the step of stirring the monomers, solvent and the free radical generating catalytic compound, during copolymerization. Preferably, the dry powder is formed by filtering excess solvent from the r ~
~ -4-precipitated powder and the filtered powder is vacuum dried.
The powder may then be "post adsorbed" with the functional material.
The powders of the present invention may also be used as carriers or adsorbents for various materials such as water, aqueous systems, emollients, moisturizers, fragrances, dyes, pigments, flavors, drugs such as ibuprofen, phosphoric acid, all categories of insect repellents, vitamins, sunscreens, detergents, cosmetics, pesticides, pheromones, herbicides, steroids, sweeteners, pharmaceuticals and antimicrobial agents. Finely divided solids such as analgesic materials can be adsorbed by dissolving the finely divided analgesic in a solvent, mixing the analgesic and solvent with the powder and removing the solvent.
Other post adsorbable materials include alkanes, alcohols, acid esters, silicones, glycols, organic acids, waxes and alcohol ethers.
These and other objects, features and advantages, of the present invention will become apparent when considered in light of the following detailed description, including the accompanying drawings.
Figure 1 in the drawings is a photomicrograph of the various components of the complex structure of the powder produced in Example I and including unit particles, agglomeratures and aggregates.
Figures 2 and 3 are photomicrographs of the agglomerates and a~gregates of Figure 1, respectively, shown on a larger scale.
Figure 4 is a photomicrograph of a polymer bead produced by suspension polymerization.
Figure 5 is a photomicrograph of the bead of Figure 4 with a portion of the shell removed to reveal the interior structure of the bead.
-5- 2 ~ 9 Figure 6 is a photomicrograph of a copolymeric powder material. The powder is shown in magnification as it appears when the agitation rate employed in the process for producing the powder is zero rpm.
Figures 7-10 are additional photomicrographs of copolymeric powder materials. The powder is shown in magnification as it appears when the agitation rate employed in the process for producing the powder varies from seventy-five rpm up to eight hundred rpm.
In the above figures in the drawing, the magnification is indicated in each instance. For example, the magnification in Figures 6-9 is lOOOX and 2000X in Figure 10. Figures 6-10 also include an insert identifying a length approximating ten microns for comparative purposes.
It should be pointed out, that in viewing the various figures, one will note that as the rate of stirring is increased from zero rpm up to eight hundred rpm, that the size of the unit particles increase. This is in direct opposition to what has been traditionally observed in suspension polymerization systems, wherein increases in stirring rates decrease particle size. Because of the increased size of the unit particles shown in Figure 10 and the resulting decrease in surface area, the adsorptive capacity of these large particles is less than the adsorptive capacity of the smaller sized particles shown in Figures 6-9.
The most effective unit particles can be produced if the rate of stirring is maintained below about three hundred rpm, although particles produced at rates beyond three hundred rpm are useful and adsorptive, but to a lesser extent.
The material of the present invention, can be broadly and generally described as a crosslinked copolymer capable of entrapping solids, liquids and gases. The -6- ~ 9~
copolymer is in particulate form and constitutes free flowing discrete solid particles even when loaded with an active material. When loaded, it may contain a predetermined quantity of the active material. One copolymer of the invention has the structural formula:
C=O C=O
R' R'' y C=O
CH
_ 3 _ X
where the ratio of x to y is 80:20, R' is -CH2CH2- and R'' is - ( CH2 ) 1 1CH3 -The copolymer is highly crosslinked as evidenced by the foregoing structural formula and is more particularly a polymethacrylate. This material is manufactured by the Dow Corning Corporation, Midland, Michigan, U.S.A. and sold under the trademark POLYTRAP~. It is a low density, highly porous, free-flowing white particulate and the particles are capable of adsorbing high levels of lipophilic liquids and some hydrophilic liquids, while at the same time maintaining a free-flowing particulate character.
In the powder form, the structure of the particulate is complex and consists of unit particles less than one micron in average diameter. The unit particles are -7- ~ 9 fused into agglomerates of twenty to eighty microns in average diameter. These agglomerates are loosely clustered into macro-particles termed aggregates of about 200 to about 1200 microns in average diameter.
Adsorption of actives to form post adsorbent powder, can be accomplished using a stainless steel mixing bowl and a spoon, wherein the active ingredient is added to the empty dry powder and the spoon is used to gently fold the active into the powder. Low viscosity fluids may be adsorbed by addition of the fluids to a sealable vessel containing the powder and tumbling the materials until a consistency is achieved. More elaborate blending equipment such as ribbon or twin cone blenders can also be employed.
The following example illustrates a method for making a post adsorbent powder, of the type illustrated in Figures 1-3 and 6-10.
EXAMPLE I
A hydrophobic porous copolymer was produced by the precipitation polymerization technique by mixing in a five hundred milliliter polymerization reactor equipped with a paddle type stirrer, 13.63 grams of ethylene glycol dimethacrylate monomer, or eighty mole percent, and 4.37 grams of lauryl methacrylate monomer, or twenty mole percent.
Isopropyl alcohol was added to the reactor as the solvent in the amount of 282 grams. The monomers were soluble in the solvent, but not the precipitated copolymer. The process can be conducted with only polyunsaturated monomers if desired.
The mixture including monomers, solvent and 0.36 grams of catalytic initiator benzoyl peroxide, was purged with nitrogen. The system was heated by a water bath to about 60~C. until copolymerization was initiated, at which time, the temperature was increased to about 70-75~C. for six hours, in order to complete the copolymerization. During this time, the copolymer precipitated from the solution. The copolymerization produced unit particles of a diameter less than about one micron. Some of the unit particles adhered together providing agglomerates of the order of magnitude of about twenty to eighty microns in diameter. Some of the agglomerates adhered further and were fused and welded one to another, forming aggregates of loosely held assemblies of agglomerates of the order of magnitude of about two to eight hundred microns in diameter. The mixture was filtered to remove excess solvent and a wet powder cake was tray dried in a vacuum oven. A dry hydrophobic copolymeric powder consisting of unit particles, agglomerates and aggregates was isolated.
The adsorptive capacity of the hydrophobic particulates produced in Example I, as a function of the stirring rate, was determined. The stirring rate during the reaction in Example I significantly influenced the adsorption properties of the particulate materials. The adsorptivity of the particulate materials decreases with an increase in stirring rate and the density of the particulates increases.
These results are set forth in Tables I-III.
5~
o :~
~-r o oo o ~ ~' ~ t~ ~ ~ . .
Ll r ~ ~ ~ oO 1 r,o r,o oo u~
v ~' --1, 0 O
~D~ U--~ aJ . . . I I
N ~1 0 0 ~1 ~
¢ ~ V~
rlO ~
~ O O
-I ~ N--~~ O-rl ~ ~ O
H ~ ~ ~ ~ rr) ,~
¢ 0 ~0 ~
X O
-I . N-- . . . .
~ O ~ ~
'¢
., u ~ I~ I~ _I ~ O ~,~
~ o O O O C~
.,1 .....
,~ _ O
~ ~1 .
U~
~, a.l-- o o o 1_1 O O ~I
~d ~ O r~ _I ~ ro .,~ _ ¢ 1~
r~
tJ ~
~r s, ~l ~ o ~ o ~
o h h c~
H ~_ O ~; O
--I ,_ ._1 J _I
h ~ a' u~
a~ o ~ o u ~: O a) ~ ~~ u~
< :~
a h o o o o a~
n X
hO ~
~~1 '5 r~
h 0 ~ 7 ll ~ g ~
--_ O O O O O r~ C~ ~ ~ U) U~
~E~OOOOOOOOOOo -I~ ~ O
r O O O O O r~ r~ r~
P~OOOOOOOOOOO
H ~ Ll'')~)1~00 0 Ir~ 1 H O ~ ~ ~ ~ ~ ~ ~ ~ ~
r~ r l O
P ~rl ~ U~
~r r~
~ h~
C~' X
L al ~ o 0 ~ u~
~r.,C-~~~ ........ .
~1 0 0 0 ~ c~0 0 ;~ ~0 0 0 0 0 o~ n ~~ a~
L~
n U~ 0 ~ U~ ~ 0 ~, . . . . . . . . .. .
a-~ ~ 000 ~ c~
~ ooo 0 0 0 1~ ~U~
r ~1 O O O O O O O O
P~ I~U l Otr~ OIl~ O O O O
1~0 0 _I
Figures 7-10 are additional photomicrographs of copolymeric powder materials. The powder is shown in magnification as it appears when the agitation rate employed in the process for producing the powder varies from seventy-five rpm up to eight hundred rpm.
In the above figures in the drawing, the magnification is indicated in each instance. For example, the magnification in Figures 6-9 is lOOOX and 2000X in Figure 10. Figures 6-10 also include an insert identifying a length approximating ten microns for comparative purposes.
It should be pointed out, that in viewing the various figures, one will note that as the rate of stirring is increased from zero rpm up to eight hundred rpm, that the size of the unit particles increase. This is in direct opposition to what has been traditionally observed in suspension polymerization systems, wherein increases in stirring rates decrease particle size. Because of the increased size of the unit particles shown in Figure 10 and the resulting decrease in surface area, the adsorptive capacity of these large particles is less than the adsorptive capacity of the smaller sized particles shown in Figures 6-9.
The most effective unit particles can be produced if the rate of stirring is maintained below about three hundred rpm, although particles produced at rates beyond three hundred rpm are useful and adsorptive, but to a lesser extent.
The material of the present invention, can be broadly and generally described as a crosslinked copolymer capable of entrapping solids, liquids and gases. The -6- ~ 9~
copolymer is in particulate form and constitutes free flowing discrete solid particles even when loaded with an active material. When loaded, it may contain a predetermined quantity of the active material. One copolymer of the invention has the structural formula:
C=O C=O
R' R'' y C=O
CH
_ 3 _ X
where the ratio of x to y is 80:20, R' is -CH2CH2- and R'' is - ( CH2 ) 1 1CH3 -The copolymer is highly crosslinked as evidenced by the foregoing structural formula and is more particularly a polymethacrylate. This material is manufactured by the Dow Corning Corporation, Midland, Michigan, U.S.A. and sold under the trademark POLYTRAP~. It is a low density, highly porous, free-flowing white particulate and the particles are capable of adsorbing high levels of lipophilic liquids and some hydrophilic liquids, while at the same time maintaining a free-flowing particulate character.
In the powder form, the structure of the particulate is complex and consists of unit particles less than one micron in average diameter. The unit particles are -7- ~ 9 fused into agglomerates of twenty to eighty microns in average diameter. These agglomerates are loosely clustered into macro-particles termed aggregates of about 200 to about 1200 microns in average diameter.
Adsorption of actives to form post adsorbent powder, can be accomplished using a stainless steel mixing bowl and a spoon, wherein the active ingredient is added to the empty dry powder and the spoon is used to gently fold the active into the powder. Low viscosity fluids may be adsorbed by addition of the fluids to a sealable vessel containing the powder and tumbling the materials until a consistency is achieved. More elaborate blending equipment such as ribbon or twin cone blenders can also be employed.
The following example illustrates a method for making a post adsorbent powder, of the type illustrated in Figures 1-3 and 6-10.
EXAMPLE I
A hydrophobic porous copolymer was produced by the precipitation polymerization technique by mixing in a five hundred milliliter polymerization reactor equipped with a paddle type stirrer, 13.63 grams of ethylene glycol dimethacrylate monomer, or eighty mole percent, and 4.37 grams of lauryl methacrylate monomer, or twenty mole percent.
Isopropyl alcohol was added to the reactor as the solvent in the amount of 282 grams. The monomers were soluble in the solvent, but not the precipitated copolymer. The process can be conducted with only polyunsaturated monomers if desired.
The mixture including monomers, solvent and 0.36 grams of catalytic initiator benzoyl peroxide, was purged with nitrogen. The system was heated by a water bath to about 60~C. until copolymerization was initiated, at which time, the temperature was increased to about 70-75~C. for six hours, in order to complete the copolymerization. During this time, the copolymer precipitated from the solution. The copolymerization produced unit particles of a diameter less than about one micron. Some of the unit particles adhered together providing agglomerates of the order of magnitude of about twenty to eighty microns in diameter. Some of the agglomerates adhered further and were fused and welded one to another, forming aggregates of loosely held assemblies of agglomerates of the order of magnitude of about two to eight hundred microns in diameter. The mixture was filtered to remove excess solvent and a wet powder cake was tray dried in a vacuum oven. A dry hydrophobic copolymeric powder consisting of unit particles, agglomerates and aggregates was isolated.
The adsorptive capacity of the hydrophobic particulates produced in Example I, as a function of the stirring rate, was determined. The stirring rate during the reaction in Example I significantly influenced the adsorption properties of the particulate materials. The adsorptivity of the particulate materials decreases with an increase in stirring rate and the density of the particulates increases.
These results are set forth in Tables I-III.
5~
o :~
~-r o oo o ~ ~' ~ t~ ~ ~ . .
Ll r ~ ~ ~ oO 1 r,o r,o oo u~
v ~' --1, 0 O
~D~ U--~ aJ . . . I I
N ~1 0 0 ~1 ~
¢ ~ V~
rlO ~
~ O O
-I ~ N--~~ O-rl ~ ~ O
H ~ ~ ~ ~ rr) ,~
¢ 0 ~0 ~
X O
-I . N-- . . . .
~ O ~ ~
'¢
., u ~ I~ I~ _I ~ O ~,~
~ o O O O C~
.,1 .....
,~ _ O
~ ~1 .
U~
~, a.l-- o o o 1_1 O O ~I
~d ~ O r~ _I ~ ro .,~ _ ¢ 1~
r~
tJ ~
~r s, ~l ~ o ~ o ~
o h h c~
H ~_ O ~; O
--I ,_ ._1 J _I
h ~ a' u~
a~ o ~ o u ~: O a) ~ ~~ u~
< :~
a h o o o o a~
n X
hO ~
~~1 '5 r~
h 0 ~ 7 ll ~ g ~
--_ O O O O O r~ C~ ~ ~ U) U~
~E~OOOOOOOOOOo -I~ ~ O
r O O O O O r~ r~ r~
P~OOOOOOOOOOO
H ~ Ll'')~)1~00 0 Ir~ 1 H O ~ ~ ~ ~ ~ ~ ~ ~ ~
r~ r l O
P ~rl ~ U~
~r r~
~ h~
C~' X
L al ~ o 0 ~ u~
~r.,C-~~~ ........ .
~1 0 0 0 ~ c~0 0 ;~ ~0 0 0 0 0 o~ n ~~ a~
L~
n U~ 0 ~ U~ ~ 0 ~, . . . . . . . . .. .
a-~ ~ 000 ~ c~
~ ooo 0 0 0 1~ ~U~
r ~1 O O O O O O O O
P~ I~U l Otr~ OIl~ O O O O
1~0 0 _I
8 ~
In the foregoing tables, it can be seen that adsorption and density, as a function of stirring rate, was determined for several fluids including a silicone oil, water, mineral oil, glycerine and an organic ester. From zero rpm up to about 250 rpm, the adsorptivity of the porous copolymeric powder particulates of Example I remained essentially consistent. However, at about three hundred rpm, there was a substantial decrease in adsorptivity, which decrease became more apparent as the stirring rate was increased up to about one thousand rpm. A similar pattern is evidenced by the data which are reflective of the density.
This phenomenon is more apparent in the photo-micrographic figures of the drawing. Thus, it can be seen from Figure 6, that the particle size of the unit particles increases as the stirring rate is increased, as evidenced by Figure 10. A progression in this phenomenon can be observed in Figures 7-9.
While the procedure of Example I is a precipitation polymerization process and not a suspension polymerization system, the prior art dealing with suspension polymerization processes, teaches that an increase in stirring rate causes a decrease in particle size. This is documented, for example, in U.S. Patent No. 4,224,415, issued September 23, 1980, and in PCT International Publication No. W0-88/01164 published February 25, 1988. The PCT International Publication employs stirring rates upwards of nine hundred to twelve hundred rpm.
In Example I of the present invention, however, increases in stirring rates not only did not decrease the particle size, but in fact had exactly the opposite effect, causing the unit particle size to increase. As the rate of stirring increased from zero rpm up to one thousand, the density of the particles increased and the adsorptive capacity decreased.
13 ~ ! ~ 7 9 In accordance with the above, it is possible to tailor porous adsorbent powders of a particular particle size and adsorptivity by means of stirring rate. Thus, with large unit particles in Figure 10, the adsorptive capacity is less than the adsorptive capacity of smaller sized unit particles in Figures 6-9. While the most effective particles are produced when the rate of stirring is maintained below about three hundred rpm, particles produced at rates beyond three hundred rpm are useful.
It is important to understand that the method of Example I for the production of porous copolymer particulate powder materials is characterized as a precipitation polymerization technique. In accordance with the technique, monomers are dissolved in a compatible volatile solvent in which both monomers are soluble. Polymer in the form of a powder is precipitated and the polymer is insoluble in the solvent. No surfactant or dispersing aid is required. The materials produced are powders and not spheres or beads. The powder particulates include unit particles, agglomerates and aggregates. The volatile solvent is subsequently removed resulting in a dry powder, which can be post adsorbed with a variety of functional active ingredients. The suspension polymerization process on the other hand, provides that polymerization be carried out in water and in some cases chloroform or chlorinated solvents. The monomers, the active and the catalyst, form beads or droplets in water and polymerization occurs within each bead. A surfactant or stabilizer, such as polyvinyl pyrrolidone, is required in order to prevent the individually formed beads and droplets from coalescing. The resulting beads, with the active material entrapped therein, include a substantially spherical outer crust or shell, the interior of which contains a macroporous structure of fused unit particles, agglomerates -14- ~ ~ 2 g and aggregates. The bead is about ten microns in average diameter to about one hundred-fifty microns, depending upon the rate of agitation employed during the process. Such beads are shown in Figures 4 and 5 and the process is set forth in Example III.
Some unique features of the powders of Example I
and Figures 1-3 and 6-10 are their ability to adsorb from sixty to eighty percent of a liquid and yet remain free flowing. The materials provide a regulated release of volatile ingredients such as cyclomethicone entrapped therein and have the capability of functioning as carriers for other non-volatile oils. Loaded powders disappear when rubbed upon a surface. This phenomenon is believed due to the fact that large aggregates of the material scatter light rendering the appearance of a white particulate, however, upon rubbing, these large aggregates decrease in size approaching the range of visible light and hence seem to disappear. The materials find applications in diverse areas such as cosmetics and toiletries, household and industrial products, pesticides, pheromone carriers and pharmaceuticals. The materials do not swell in common solvents and are capable of physically adsorbing active ingredients by the filling of interstitial voids by capillary action. The active ingredients are subsequently released by capillary action or wicking from the voids within the particulates.
The following example illustrates a precipitation polymerization process in which an organic ester is entrapped "in situ" in the polymer powder.
EXAMPLE II
7 grams of 2-ethylhexyl oxystearate was mixed with 1.5 grams of ethylene glycol dimethacrylate and 1.5 grams of lauryl methacrylate in a glass test tube. The solution was deaerated for five (5) minutes and 0.1 ml of t-butyl g peroctoate was added and mixed while heating to 80~C. in an oil bath. After 20 minutes, the contents solidified; and the mixture was maintained at about 80~C. for an additional hour to assure full polymerization. A semi-soft, heterogeneous white opaque polymer mass resulted containing the entrapped ester.
The powder of Example II differs from the powder of Example I in that the solvent in Example I is removed resulting in a dry empty powder which is post adsorbed with other functional materials. The powder of Example II is otherwise similar to the material shown in Figures 1-3.
Example III illustrates a process for the production of beads as shown in Figures 4 and 5. The process is suspension polymerization and an organic ester is entrapped "in situ".
EXAMPLE III
1.20 grams of polyvinyl pyrrolidone was dissolved in 1500 ml of water in a 2000 ml three necked resin flask equipped with a stirrer, thermometer and nitrogen purge. A
solution of 335 grams of 2-ethylhexyl oxystearate, 132 grams ethylene glycol dimethacrylate, 33 grams 2-ethylhexyl methacrylate and 5 ml t-butyl peroctoate, was bubbled with nitrogen for 5 minutes. The resultant mix was slowly added to the stirred aqueous solution of polyvinyl pyrrolidone at 22~C. under nitrogen. The temperature was raised to 80~C.
with constant agitation and held until polymerization started in approximately 15 minutes and maintained at 80~C. for an additional 2 hours to complete the reaction. Semi-soft, white opaque beads were collected by filtering off the supernatant liquid and dried to remove any excess water. The beads weighed 450 g for a yield of 90% and were 0.25 to 0.5 mm in diameter. Other protective colloids such as starch, polyvinyl alcohol, carboxymethyl cellulose, methyl cellulose or inorganic systems such as divalent alkali metal hydroxides, for example Mg(0~2,may be used in place of the polyvinyl pyrrolidone suspen~ing medium.
In Example III macroporous polymers submicron in size are produced with two or more monomers, at least one monomer of which contains more than a single double bond.
The polymerization is conducted in the presence of an active ingredient which does not dissolve or swell the resulting polymer. The monomers and the active ingredient are mutually soluble, but are insoluble in the aqueous suspen~; ng medium in which droplets are formed. Polymerization occurs within suspended droplets and beads or spheres are produced. The active ingredient which is polymerized "in situ" is entrapped and contained within the beads, but the active ingredient is capable of being released. It is also possible to use a volatile liquid during polymerization and to subsequently thermally drive off the volatile liquid, leaving behind a porous polymer bead product into which a variety of active materials can be subsequently adsorbed.
Examples of polyunsaturated monomers suitable for use in accordance with the present invention are ethylene glycol dimethacrylate, triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, trimethylol propane ethoxylated triacrylate, ditrimethylol propane dimethacrylate; propylene, dipropylene and higher propylene glycols, 1,3 butylene glycol dimethacrylate, 1,4 butanediol dimethacrylate, 1,6 hexanediol dimethacrylate, neopentyl glycol dimethacrylate, pentaerythritol dimethacrylate, dipentaerythritol dimethacrylate, bisphenol A dimethacrylate, divinyl and trivinyl benzene, divinyl and trivinyl toluene triallyl maleate, triallyl phosphate, diallyl maleate,' diallyl itaconate and allyl methacrylate. The mono-unsaturated monomers include allyl methacrylates and -17- 203082~
-acrylates having straight or branched chain alkyl groups with 1 to 30 carbon atoms, preferably 5 to 18 carbon atoms.
Preferred monomers include lauryl methacrylate, 2-e~hylhexyl methacrylate, isodecylmethacrylate, stearyl methacrylate, hydroxy ethyl methacrylate, hydroxy propyl methacrylate, diacetone acrylamide, phenoxy ethyl methacrylate, tetra-hydrofurfuryl methacrylate and methoxy ethyl methacrylate.
As noted previously, the copolymer can be formed by copolymerizing one monounsaturated monomer with one polyunsaturated monomer or with only polyunsaturated monomers.
EXAMPLE IV
Example I was repeated for each of a series of monomer systems shown in Tables IV-XVII. In each instance, submicron sized copolymeric powders were produced employing a stirring speed of about seventy-five RPM. The catalyst was benzoyl peroxide. Adsorption capacities of the various copolymeric powders for fluids were determined and are shown in the Tables, along with the mole ratios of monomers and the solvent. The abbreviations used in Tables IV-~VII are identified as follows:
DAA Diacetone a~rylamide EGDM Ethylene glycol dimethacrylate TEGDM Tetraethylene glycol dimethacrylate ST Styrene DVB Divinylbenzene VP Vinyl pyrrolidone IBOMA Isobornyl methacrylate PEMA Phenoxyethyl methacrylate IDMA Isodecyl methacrylate STMA Stearyl methacrylate HPMA Hydroxypropyl methacrylate CYMA Cyclohexyl methacrylate ~0~9 DMAEMA Dimethylaminoethyl methacrylate TBAEMA t-butyl aminoethyl methacrylate AMPS 2-acrylamido propane sulfonic acid BMA Butyl methacrylate EHMA 2-ethylhexyl methacrylate MMA Methyl methacrylate HEMA 2-hydroxyethyl methacrylate EH0 2-ethylhexyl oxystearate GG Glucose glutamate IPA Isopropyl alcohol PEG Polyethylene glycol 200 TABLE IV
Adsorption Capacity %
Mole Monomers Ratio Solvent EHO Glycerine GG Water DAA/EGDM 20/80 Xylene 75 82 83 78 DAA/EGDM 30/ 70 Xylene 77 80 83 78 DAA/EGDM 40/60 Xylene 75 75 83 77 DAA/EGDM 50/50 Xylene 50 57 67 0 DAA/EGDM 60/40 Xylene 40 40 50 0 DAA/TEGDM 20/80 Xylene 40 50 62 58 DAA/TEGDM 30/ 70 Xylene 29 40 50 55 DAA/TEGDM 40/60 Xylene 25 28 40 43 DAA/TEGDM 50/50 Xylene 25 30 40 43 DAA/TEGDM 60/40 Xylene 22 29 40 40 ~.. '~
C~
G~
2 ~ ' 29 oo ~ ~ o o o o o o o o 0~
h a~ ~ co O O u~ u~ I~ I~ r~ ~D O
Cr o ~~
~,1 ~ ~ ~ rJOoo ~ ~ I~ ~ r~ ~ O
r~1 C~
~: ~ I Oooo C~l ~ O O ~ O u~ ~ ~ O
u~ H H H H H H H H H H H H H 1-1 O O O O O O O O O O O O O O O
r~ 4 o ~ o o o o o o o o O O O o O o L L L L L L L
TABLE VI
Adsorption Capacity %
Monomers Ratio Solvent EH0 Glycerine GG Water VP/EGDM 20/80 Xylene 77 80 74 73.6 VP/EGDM 30/70 Xylene 76 79 78.3 70 VP/EGDM 40/60 Xylene 70 67 75.6 75 VP/EGDM 50/50 Xylene 72 76 80 76 VP/EGDM 60/40 Xylene 74 80 76 77 VP/TEGDM 20/80 Xylene 58 68.8 61.5 67.7 VP/TEGDM 30/70 Xylene 70 67 54.5 68.8 VP/TEGDM 40/60 Xylene 54.5 61.5 52.4 64.3 VP/TEGDM 50/50 Xylene 44.4 47.4 52.4 52.4 VP/TEGDM 60/40 Xylene 50 44.4 50 54.4 VP/TEGDM 70/30 Xylene 50 47.4 44.4 50 ~3 VP/TEGDM 80/20 Xylene 54.5 52.4 60 58 ~3 -q ~
o o o o o o o o o o o o o o ~ ~l~ u) ~ ~ ~ u~~D ~I~u~ r~
r C~r~1~r~0~ 0 1~ ~ r~ O r~ ~ ~ r~
t ~J
o . . . . . . . . . . . .
~ r~ ~ ~D ~ O r~
r~
rC!~
0~ ~~001~0 0C~~Dr;
~
U~H H H H H H H H H H H H H H
O O O O O O O O O O O O O O O
r~ ~
O ~ O O O O O O O O O O O O O O
L LLL L L L
a) O ~ C _ C _ C C r O
o : m : : : ~
-- H------1~ --1------ H
2 ~
a ~ ~ . . . . . .
,~ o o o o 0 c~
J~ ~
~ O O ~ ~Dr~ ~ ~ ~ c~ ~D
L
~J
g a~
. . . . . . . . . . . .
X O~ ~ 0 ~ 0 ~D O1~ 0 ~ 0 :> ~~~ ~ D 0 ~ ~~D 0 0 1 a~
U~H H H H H H H H H H H H H H
COOOOOOO OOOOOOO
o~ooooooo ooooooo D 1~ 0 ~ ~ ~u~ ~ 0 ~ _ _ _ _ _ _ -- - , _ _ .
CQ5 ; 5 5 5 .5 5 . ~ ~
L L L~L L L L
E -- --o o o o o o o o o o r~.
h o ~ ~ I~ a~ o c~ ~ O O
~, g a~
O ~ o c~ ~ ~ u ~, ,~
C~
O u~ 0 o 0 0 c~ O ~ 0 0 ,~ ¢ ~ ¢
O P~ ~ ~ ~ ~ ~ ~ ~ P ~
u~ H H H H H H H H H H
O o o o O O O O O O O
,~ 4 O r O O O O O O o O O O
u~ -i 3 ~ L L ~ L L
~Ll Ll ~1 - -E-l - -f -- -- --~o ~
~ ~ H 1-1_ 1_ ~ ~ ~ ~ ~
2~
o o o o o o o o o h I~ u~ u~ ~ ~ ~ ~ u~
C~
~r ~ ~D Irl r l 00 C~l C~ O 00 ~D
L
O
j~ .,1 . ... ...
r l C~
P~ ~ ~
01 ~ ~ IJ'l r-l ~ O O ~ 1 o O ~ ~ ~ ~ ~ ~ ~ ~ ~
U~ H H H H H H H H H
C O O O O O O O O O
~U ~r a~ 0 1~ ~D ~)O~ I~ ~O U') r-l ~
O ~ O O O O O O O O O
,~
3 3 L L ~ L
Ei -- -- --O ~
2 ~ 9 ~, . . . .
~ ~ O O O O O O_I O~ ~D ~ O
~~ ~ _1 00 C~ O 001~ 00 ~ O
L
~r ~, ~, ~, . . . . . . . . . . . .
P
~.~
K 0~ ~ ~ ~r~ ~ o ~1 o~D o c~ ~ ~ o ~I
r~ r~r~ ~r~_~r~_I r~r~r~_Ir~r~r~
O h h hh h h h hh h h h h h X P~ xPq xPCPC xP~ PC
G O O OO O O O OO O O O O O
~-r 0 ~ ~DU~ ~ ~ ~~ t~~D
r~ ~
O ~ O O OO O O O OO O O O O O
;.~ LL L L L L L
~ ~ $ ~ X ~
g ~ 9 ~a~ ~
~. o o o o o o ~ o o o o o o o ~ .
b~
C~
t_ r ~J
O
~ O O O O O O O
H Ir) u) c~
O
~ ~ O ~ ~ ~ ~ ~ I ~ O ~ ~1 U~ H H H H H H H H H H H H H H
O O O O O O O O O O O O O O
O ~ O O O O O O O O O O O O O O
~q 5 5 ; 5 -5 5 5 h ~ L L L L L L L
~0 ;~ ;~; g g, g g. g, ~ g -g' g g g g o ~ 0~ 0 ~Dr~l O O
V) 4~:) ~ ~ ~ ~ . . . .
~rO ~D O C~ 00 u~ c~00 ~~0 n~ r-1 C~
~rl OO
4r~l. . . . . . . .
'4 c~ 0~r~l r-l 0 0~D r~
~ a ~ S
H
H ~ I~<r~I~
H ~1~ ~ . .
X ~ O~I~ ~ O O O O
00 ~v ' O
U~ _ _ -- -- _ -- -- -- _ O O O O O O O O O O
a~-r o r~l 4 O ~ O O O O O O O O O
r~; r; ; r; r; ; ; r; r;
vl h a~
O S. S ~ ~ S ~ S
o ~ a 2 ~
~ 0~~D 00 t~
o $ ~ oo o ~, ~ oo 00 ~D1~ ~D r~ u~
a~
._1 r~
h ~ ~ ~ o ,1 L ~
c ~~1 o O
. . . . .
O O~D c~l S 0~
n a .. ..
:>
H S ~
K a ~ o o o o o ~, C a~ aa ~ o ~ a a~
a~ ~ h ~ ~I y Y OX K
O h '' cn K _ -- ~1~:_ _ o o o o o o a~- oo x ~
~ IJ
O cr o o o o o o a~
o u~
C ~
.~ a ~ g ~ r~
o ~ . . .
:r: ~ ~ o ~ o o o a h l t~ I~ I~ r.~ ~ r,~-) r~
,~ ~ . . . . . .
~r ~ D r~o r,r r-l ~r r~
~rl O O
r ~rl P~ ~
O O O O O OO
O ~:
O ¢ ¢ ¢ ¢ ¢ ¢ ¢
rJ~ H H H H HH H
G O O O O OO O
r~ I
o ~r o o o o oo o -5 -5 ~ -55 o~
g _ ~5i '.~9 ~ ~ U~ ~ Y~
o I oo ~ ~ a~
u~
a) . ,, ~L~ ~ . . . . . .
~r L C~
~J
~~
o O
~ J o _~
o a P~ a 0 ~
~ ~ ~, .
o P~ ~ P~ ~ ~ ~ ~
U~ H H H H H H H
O O O O O O O O
O cr O O O O O O O
cq--------___ 5 5 ~ ~ ~
3 ~ ;~
O
u~
o :~:
~ u~
h ~rl ~, a~ . . . . . .
U ~ oo ~ ~ ~ o~ ~
~' h u~ u ) ~D ~ ~ ~ ~D
L
o . ~ U~ ~ U~ U~
,~ ,~ ~ ~ oo H
H
:' a, . .. . . .
-I 'C ~ ~ ~ ¢ 'C
0 ~4 ~ ~ ~ ~ P~ ~
U~ H H H H H H H
O O O O O O O O
~1 ~
o ~r o o o o o o o 5~S' ' --h ~o ~
I' d The water adsorbing porous polymeric materials produced above in some instances are to be contrasted with the water containing beads of U.S. Patent No. 3,627,708, issued December 14, 1971. The bead of the '708 patent is produced by "in situ" suspension polymerization and is adapted to contain water only because of the presence of a solubilizer such as sodium bis(2-ethyl hexyl) sulfosuccinate.
The materials of Example IV, on the other hand, are produced by a precipitation polymerization process, which contains no solubilizer and produces a material in the form of a powder consisting of unit particles, agglomerates and aggregates.
Thus, these materials are very distinct from the materials of the '708 patent.
The particulates of the present invention can be used as a carrier and the particulate carrier means can be in the form of micron-sized beads or the particulate carrier means can be in the form of a powder. In the latter case, the powder constitutes a combined system of particles, the system of powder particles including unit particles of a size less than about one micron in average diameter, agglomerates of fused unit particles of sizes in the range of about twenty to about eighty microns in average diameter and aggregates of clusters of fused agglomerates of sizes in the range of about two hundred to about twelve hundred microns in average diameter.
As noted above, highly crosslinked, polymeric systems consisting of particles of submicron size, can be prepared from monomers having at least two polymerizable unsaturated bonds and containing no comonomers having monounsaturated moiety. These highly crosslinked systems can adsorb large quantities of active substances even of very different structures and properties.
2 ~
Examples of such monomers are bis or poly acrylates, methacrylates or itaconates of ethylene glycol, propylene glycol, di-, tri-, tetra-, polyethylene glycol and propylene glycol, trimethylol propane, glycerine, erythritol, xylitol, pentaerythritol, di-pentaerythritol, sorbitol, mannitol, glucose, sucrose, cellulose, hydroxy cellulose, methyl cellulose; 1,2 and 1,3-propanediol; 1,3 and 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol and cyclohexanediol and triol. Similarly, bis acrylamido or methacrylamido compounds can be used, such as methylene bis acryl or methacrylamide, 1,2-dihydroxy ethylene bis-acryl or methacrylamide and hexamethylene bis-acryl or methacrylamide.
Another group of monomers are represented by di or poly vinyl esters such as divinyl oxalate, malonate, succinate glutarate, adipate, sebacate, divinyl maleate, fumarate, citraconate and mesaconate.
Still another group of monomers is represented by di or poly vinyl ethers of ethylene, propylene, butylene, glycols of glycerine, pentaerythritol, sorbitol, divinyl ether, di or poly-allyl compounds based on glycols and glycerine or combinations of vinyl allyl or vinyl acryloyl compounds such as vinyl methacrylate, acrylate, allyl methacrylate, acrylate and methallyl methacrylate, acrylate.
Aromatic, cycloaliphatic or heterocyclic monomers such as divinyl benzene, toluene, diphenyl, cyclohexane, trivinyl benzene, divinyl pyridine and piperidine, can also be used.
The polymerization is achieved by the use of a variety of free radical initiators which can be azo compounds, a peroxy dicarbonate, a peroxy ester or a sulfonyl acid peroxide. Illustrative of free radical initiators in the process are 2,2'-azobis(2,4-dimethyl-4-methoxy valeronitrile), benzoyl peroxide, 2,2'-azobis-(2,4-dimethylvaleronitrile), 2,2'-azobis (isobutyronitrile), 2-t-butylazo-2-cyano-4-methoxy-4-methylpentane, acetyl peroxide, 2-t-butylazo-2-cyano-4-methylpentane, 2,4-dichloro-benzoyl peroxide, p-chlorobenzoyl peroxide, decanoyl~' peroxide, diisononanyl peroxide, lauroyl peroxide, propinoyl peroxide, bis(4-t-butyl cyclohexyl) peroxy dicarbonate, di(sec-butyl) peroxy dicarbonate, diisopropyl peroxy carbonate, di(n-propyl) peroxy carbonate, di(2-ethylhexyl) peroxy carbanate, di(2-phenoxyethyl) peroxy carbonate, t-amyl peroxy pivalate, t-amyl pel~iv~late, t-butyl peroxyacetate, t-butyl pero~yi~obut~rate, t-butyl peroxypivalate, t-butyl peroxy neotecanonate, t-amyl perneodecanonate, cumyl perneodecanonate, cumylperpivalate, 2,5-dimethyl-2,5-bis(2-ethyl ~Y~nQyl peroxy) hexane, t-butylperoxy-2-ethyl-hexanoate, t-amyl peroxy (2-ethylhexanoate) and acetyl cyclohexyl sulfonyl peroxide.
Illustrative redox initiators are methylbutyl amine, bis(2-hydroxyethyl)butyl amine, butyldimethyl amine, dimethyl amine, dibenzylethyl amine, diethylmethyl amine, dimethylpentyl amine, diethyl amine, 2,21,2"-trihydroxy dipropyl ethyl amine, di-n-propylene amine, 2,2',2"-trimethyl tributyl amine, triethyl amine, dimethyl aminoacetal, pentylhexyl amine, triethanolamine, trihexyl amine, trimethyl amine, trioctadecyl amine, tripropyl amine, trisopropyl amine, tetramethylene diamine and esters of para-amino benzoic acid, e.g., p-dimethyl amino-2-ethylhexyl-benzoate, dimethyl aminoethyl acetate, 2-(n-butoxy)ethyl 4-dimethyl-aminobenzoate, 2-(dimethylamino) ethyl benzoate, ethyl-4-dimethylaminobenzoate, methyldiethanolamine, dibutyl amine, N,N-dimethylbenzylamine, methylethyl amine and dipentyl amine.
The plastic material in which the polymer '' containing the entrapped insect repellent is incorporated may constitute any of a wide variety of thermoplastic or ., thermosetting resins, with the proviso that the chemical repellent composition be compatible with the material selected. The resins may be in the form of pellets, granules and powders. Exemplary materials are polyoxymethylene, acrylics, cellulosics, fluoroplastics, nitrile resins, Nylons, polyamide-imides, polyarylates, polybutylene, polycarbonates, polybutylene terephthalate, polyethylene terephthalate, polyetherimides, polyethylene, ethylene-ethyl-acrylate, polymethylpentene, polypropylene, acrylonitrile-butadiene-styrene, acrylic-styrene-acrylonitrile, polystyrene, styrene-acrylonitrile, styrene-butadiene, sulfone based resins, thermoplastic elastomers, vinyl based resins, epoxies, phenolic resins and polyesters.
In the case of thermoplastic resins, the polymer containing the entrapped insect repellent is incorporated into the resin during the extrusion process. If other processes are used such as coating, molding, thermoforming or calendering, the polymer containing the entrapped insect repellent is incorporated into the resin during such processes. In the case of thermosetting resins, the polymer is incorporated during the compression molding operation. It is preferable to incorporate the polymer into the resin prior to melt processing in order to insure a uniform dispersal in the resin matrix. The resins can then be blown or cast into film, injection or blow molded or extruded. The effective-ness of products so produced will vary from a period of days in the case of thin films to years in compression molded wall panels. The polymer may also be incorporated into reinforced types of resins, if desired. The insect repellent may be entrapped into the macroporous polymer bead or powder of the present invention in accordance with the procedures of 203082~
Example I or II in the case of a powder form or Example III
in the case of the bead form.
For purposes of the present invention, t~ë term "unexpanded" is intended to mean plastics other than cellular materials containing an appreciable fraction of uniformly dispersed voids or cells whether classified as open-celled or closed-celled. Thus, open foams of the type in U.S. Patent No. 4,828,542, issued May 9, 1989, would not be included among the types of plastic materials intended under the present invention.
As noted previously, the preferred chemical for use as the insect repellent is N,N-diethyl-m-toluamide, commonly referred to as DEET. Other repellent chemicals that may be employed include, for example, dimethyl phthalate; Rutgers 6-12 2-ethyl-1,3-hexanediol; ~Stabilene"~, MGK Repellent 326, Indalone; dibutyl phthalate; MGK Repellent 11; Citronyl;
alicyclic piperidines; Permethrin; dibutyl succinate;
hexahydrodibenzofuran carboxaldehyde-butadiene-furfural copolymer; tert-butyl N,N-dimethyldithiocarbamate;
2-hydroxyethyl n-octyl sulfide; pyrethrins; ~iazinon;
Aldicarb; pine oil; and anthrahydroquinones. Such chemicals are effective against various categories of mo~quitos, ticks, chiggers and cockroaches.
The following examples illustrate the concept of the present invention.
EXAMPLE V
Into a mixing bowl was placed ten grams of the powder of Example I. To the powder was added forty grams of liquid insecticide diethyltoluamide. The mixture was blended with a spoon until uniform. The powder readily absorbed the liquid insecticide, entrapping the insecticide therein 'and yet r~ ~;ning free flowing. The powder with the entrapped insecticide therein is suitable for incorporation into resin ~Trade mark ,....
?~' Og~
matrices for the production of insect repelling articles of manufacture. Larger quantities of the powder containing the entrapped insecticide may be produced by employing a Patterson-Kelly Twin Cone Blender.
EXAMPLE VI
A four liter polymer kettle containing two-hundred milliliters of distilled water and two-hundred milliliters of pine oil was flushed with nitrogen. The solution was mixed and the temperature raised to approximately 85~C. To the kettle was added five-hundred milliliters of twenty percent by weight of divinylbenzene, five percent by weight of benzoyl peroxide and the remainder styrene. After thirty minutes, the polymerization ceased and the polymer bead entrapping the pine oil insecticide was collected by filtration.
EXAMPLE VII
A mixture of finely ground sulfonated styrene-divinylbenzene polymer containing fifteen percent divinyl-benzene and polyethylene pellets was heated to 180~C., kneaded in a mixture and pelletized to one sixteenth of an inch pellets. The pellets were fed to a screw extruder.
Prior to extrusion into one mil sheets, particles of insecticide entrapped styrene-divinylbenzene beads prepared in accordance with Example VI were added. The resulting sheets were cut into strips and used as animal collars and as insecticidal strips in homes and restaurant establishments.
While the foregoing disclosure specifies various uses of the materials of the present invention, as well as various types and compositions of ingredients which may be entrapped within these and similar materials, the patent literature is replete with uses and ingredients which may be entrapped in these and similar materials. For example, U.S.
Patent No. 4,690,825, discloses as active ingredients ~~ ~39~ 2 0 3 0 8 2 q lubricants, emollients, moisturizers, pigments, insect or flea repellents, fragrances, vitamins and drugs. When the active ingredient is a drug, it is said to include~
anti-infectives such as antibiotics, fungicides, scabicides, pediculicides, iodine, anti-inflammatory agents, antipruritics, astringents, anti-hidrotics, keratolytic agents, caustics. keratoplastic agents, rubefacients, sunscreens, demulcents, protectants and detergents. Uses of loaded beads includes cosmetic preparations such as hand creams, acne products, deodorants, antiperspirants, baby powders, foot powders, body powders, lip ices, lip sticks, baby creams and lotions, mouthwashes, dentifrices, medicated facial creams and lotions, shampoos, shaving creams, pre- and after-shave lotions, depilatories and hairgrooming preparations.
U.S. Patent No. 4,724,240, names as active ingredients ethylhexyl oxystearate, arachidyl propionate, ethylhexyl adipate, isopropyl myristate, ethanol, stearyl alcohol, propylene glycol, propionic acid, stearic acid, polyoxypropylene cetyl alcohol, ~Carbowax~*,polyethylene glycol, petroleum jelly, mineral oil, mineral spirits, lanolin, acetylated lanolin, isopropyl lanolate, hexamethyl-disiloxane, cyclic polydimethyl~iloxanes, polyphenylmethylsilo~anes, polydimethyl-trimethylsiloxanes;
phenyl, ethyl and vinyl-substituted polysilanes; and cosmetic dyes. Materials loaded with such ingredients are said to be useful in cosmetic, beauty, toiletry and healthcare products, insecticides, disinfectants, flavors, perfumes, antiperspirant wax or oil base sticks, deodorants, colognes, pressed powders and toilet soaps.
Entrapped functional materials in the Published European Application No. 0252463A2 published January 13, 1988, are said to encompass pigments, perfumes, pheromones, ~Trade mark '2~
-synthetic insect attractants, pesticides including juvenile hormone analogs, herbicides, pharmaceuticals, antimicrobial agents, sunscreens, light stabilizers, fragrances, flavors including sweeteners and various chemicals. Of the various chemicals disclosed are menthol, soybean oil, Vitamin E, salicylic acid, squalane, simethicon, bromochlorinated paraffin, benzophenone, petroleum distillate, jojoba oil and citrus oil. The published application also specifically identifies and names four pheromones, twenty pesticides, twenty-three fragrances, about thirty-seven chemicals and some twenty-two emollients, that may be entrapped in the materials as active ingredients.
In the Patent Cooperation Treaty International Publication No. W0/88/01164, there is also listed as specifically named ingredients which may be loaded into the beads approximately twenty-two ultraviolet absorbers, nineteen insect repellants and thirty emollients. The publication also names several steroids including adrenocortical steroids such as fluocinolone, fluocinolone acetonide, triamcinolone acetonide, beta-methasone valerate, timobesone acetate, hydrocortisone, hydrocortisone acetate, triamcinolone, prednisolone, prednisolone acetate, dexamethasone, beclomethasone dipropionate, betamethasone diproprionate, betamethasone benzoate, clocorolone pivalate, halcinonide, flumethasone pivalate and desonide.
European Published Application No. 0306236A2, published March 3, 1989, discloses "in situ" and "post absorbed" suspension polymerized beads loaded with six different categories of active ingredients. The six categories of active ingredients are hair growth promoters, acne treatments, fragrances, vitamins, pain relievers and epidermal lipid substitutes. The hair ~rowth promoter is Minoxidil. For acne treatment there is employed benzoyl peroxide, salicylic acid and resorcinol. Fragrances include flower oils, essential oils, animal and synthetic fragrances and resinoids. Some thirty-nine specific fragrances are named. Vitamins include A, D, E, K, Bl, B2, B12, B15, B17, C, niacin, folic acid, panthotenic acid, biotin, bioflavinoids, choline, inositol and F. Cod liver oil and retinoids are also disclosed. Some twenty-two pain relievers and some twenty-two mixtures and combinations of various pain relievers are disclosed, among which are menthol, camphor and methyl salicylate. The epidermal lipid substitutes are squalane and squalene. The six categories of loaded beads may be used alone or as topical applications in creams, ointments, lotions and oils. In addition, the fragrance loaded beads can be added to perfumes, colognes, cosmetics, soaps, paper products, detergents and body and foot powders.
The vitamin loaded beads also find application in lip balms, lipsticks, eye shadows, foundations and blushers.
In U.S. Patent No. 4,719,040, issued January 12, 1988, a porous polymer powder laden with perfume is included as an ingredient in an aqueous air freshener gel. U.S.
Patent No. 4,764,362, issued August 16, 1988, and a divisional thereof U.S. Patent No. 4,813,976, issued March 21, 1989, relate to emery boards including an emollient entrapped onto an absorbent acrylates copolymer powder.
Filing of a nail releases the emollient which conditions and lubricates the nails and cuticles. A toothpaste containing dental flossing tape is disclosed in U.S. Patent No. 4,776,358, issued October 11, 1988. Included as an ingredient of the dentifrice are "microsponges" containing a flavor oil. In U.S. Patent No. 4,828,542, issued May 9, 1989, particles entrapping various functional materials are bonded to the surfaces of an expanded reticulated polyurethane foam. Among the enumerated functional materials 2~3~
which may be entrapped are adhesives; pharmaceuticals such as insulin, interferon, albumin, hormones and monoclonal antibodies; flavors; fragrances for perfume samplers, air fresheners and drawer liners; colors; inks; liquid crystals;
oils; waxes; solvents; resins; fire extinguishing agents;
insect repellants for mothballs and flea and tick applications; agricultural chemicals such as insecticides, fungicides and heromones; disinfectants; cosmetics such as skin lotions, hair care products, sunscreens and mouth wash;
vitamins; antiperspirants; contraceptives; medicants such as Benzocaine, transdermal drugs, analgesics, allergy bacteria, methyl salicylate and nitroglycerin.
It will be apparent from the foregoing that many other variations and modifications may be made in the structures, compounds, compositions and methods described herein without departing substantially from the essential features and concepts of the present invention. Accordingly, it should be clearly understood that the forms of the invention described herein are exemplary only and are not intended as limitations of the scope of the present invention.
In the foregoing tables, it can be seen that adsorption and density, as a function of stirring rate, was determined for several fluids including a silicone oil, water, mineral oil, glycerine and an organic ester. From zero rpm up to about 250 rpm, the adsorptivity of the porous copolymeric powder particulates of Example I remained essentially consistent. However, at about three hundred rpm, there was a substantial decrease in adsorptivity, which decrease became more apparent as the stirring rate was increased up to about one thousand rpm. A similar pattern is evidenced by the data which are reflective of the density.
This phenomenon is more apparent in the photo-micrographic figures of the drawing. Thus, it can be seen from Figure 6, that the particle size of the unit particles increases as the stirring rate is increased, as evidenced by Figure 10. A progression in this phenomenon can be observed in Figures 7-9.
While the procedure of Example I is a precipitation polymerization process and not a suspension polymerization system, the prior art dealing with suspension polymerization processes, teaches that an increase in stirring rate causes a decrease in particle size. This is documented, for example, in U.S. Patent No. 4,224,415, issued September 23, 1980, and in PCT International Publication No. W0-88/01164 published February 25, 1988. The PCT International Publication employs stirring rates upwards of nine hundred to twelve hundred rpm.
In Example I of the present invention, however, increases in stirring rates not only did not decrease the particle size, but in fact had exactly the opposite effect, causing the unit particle size to increase. As the rate of stirring increased from zero rpm up to one thousand, the density of the particles increased and the adsorptive capacity decreased.
13 ~ ! ~ 7 9 In accordance with the above, it is possible to tailor porous adsorbent powders of a particular particle size and adsorptivity by means of stirring rate. Thus, with large unit particles in Figure 10, the adsorptive capacity is less than the adsorptive capacity of smaller sized unit particles in Figures 6-9. While the most effective particles are produced when the rate of stirring is maintained below about three hundred rpm, particles produced at rates beyond three hundred rpm are useful.
It is important to understand that the method of Example I for the production of porous copolymer particulate powder materials is characterized as a precipitation polymerization technique. In accordance with the technique, monomers are dissolved in a compatible volatile solvent in which both monomers are soluble. Polymer in the form of a powder is precipitated and the polymer is insoluble in the solvent. No surfactant or dispersing aid is required. The materials produced are powders and not spheres or beads. The powder particulates include unit particles, agglomerates and aggregates. The volatile solvent is subsequently removed resulting in a dry powder, which can be post adsorbed with a variety of functional active ingredients. The suspension polymerization process on the other hand, provides that polymerization be carried out in water and in some cases chloroform or chlorinated solvents. The monomers, the active and the catalyst, form beads or droplets in water and polymerization occurs within each bead. A surfactant or stabilizer, such as polyvinyl pyrrolidone, is required in order to prevent the individually formed beads and droplets from coalescing. The resulting beads, with the active material entrapped therein, include a substantially spherical outer crust or shell, the interior of which contains a macroporous structure of fused unit particles, agglomerates -14- ~ ~ 2 g and aggregates. The bead is about ten microns in average diameter to about one hundred-fifty microns, depending upon the rate of agitation employed during the process. Such beads are shown in Figures 4 and 5 and the process is set forth in Example III.
Some unique features of the powders of Example I
and Figures 1-3 and 6-10 are their ability to adsorb from sixty to eighty percent of a liquid and yet remain free flowing. The materials provide a regulated release of volatile ingredients such as cyclomethicone entrapped therein and have the capability of functioning as carriers for other non-volatile oils. Loaded powders disappear when rubbed upon a surface. This phenomenon is believed due to the fact that large aggregates of the material scatter light rendering the appearance of a white particulate, however, upon rubbing, these large aggregates decrease in size approaching the range of visible light and hence seem to disappear. The materials find applications in diverse areas such as cosmetics and toiletries, household and industrial products, pesticides, pheromone carriers and pharmaceuticals. The materials do not swell in common solvents and are capable of physically adsorbing active ingredients by the filling of interstitial voids by capillary action. The active ingredients are subsequently released by capillary action or wicking from the voids within the particulates.
The following example illustrates a precipitation polymerization process in which an organic ester is entrapped "in situ" in the polymer powder.
EXAMPLE II
7 grams of 2-ethylhexyl oxystearate was mixed with 1.5 grams of ethylene glycol dimethacrylate and 1.5 grams of lauryl methacrylate in a glass test tube. The solution was deaerated for five (5) minutes and 0.1 ml of t-butyl g peroctoate was added and mixed while heating to 80~C. in an oil bath. After 20 minutes, the contents solidified; and the mixture was maintained at about 80~C. for an additional hour to assure full polymerization. A semi-soft, heterogeneous white opaque polymer mass resulted containing the entrapped ester.
The powder of Example II differs from the powder of Example I in that the solvent in Example I is removed resulting in a dry empty powder which is post adsorbed with other functional materials. The powder of Example II is otherwise similar to the material shown in Figures 1-3.
Example III illustrates a process for the production of beads as shown in Figures 4 and 5. The process is suspension polymerization and an organic ester is entrapped "in situ".
EXAMPLE III
1.20 grams of polyvinyl pyrrolidone was dissolved in 1500 ml of water in a 2000 ml three necked resin flask equipped with a stirrer, thermometer and nitrogen purge. A
solution of 335 grams of 2-ethylhexyl oxystearate, 132 grams ethylene glycol dimethacrylate, 33 grams 2-ethylhexyl methacrylate and 5 ml t-butyl peroctoate, was bubbled with nitrogen for 5 minutes. The resultant mix was slowly added to the stirred aqueous solution of polyvinyl pyrrolidone at 22~C. under nitrogen. The temperature was raised to 80~C.
with constant agitation and held until polymerization started in approximately 15 minutes and maintained at 80~C. for an additional 2 hours to complete the reaction. Semi-soft, white opaque beads were collected by filtering off the supernatant liquid and dried to remove any excess water. The beads weighed 450 g for a yield of 90% and were 0.25 to 0.5 mm in diameter. Other protective colloids such as starch, polyvinyl alcohol, carboxymethyl cellulose, methyl cellulose or inorganic systems such as divalent alkali metal hydroxides, for example Mg(0~2,may be used in place of the polyvinyl pyrrolidone suspen~ing medium.
In Example III macroporous polymers submicron in size are produced with two or more monomers, at least one monomer of which contains more than a single double bond.
The polymerization is conducted in the presence of an active ingredient which does not dissolve or swell the resulting polymer. The monomers and the active ingredient are mutually soluble, but are insoluble in the aqueous suspen~; ng medium in which droplets are formed. Polymerization occurs within suspended droplets and beads or spheres are produced. The active ingredient which is polymerized "in situ" is entrapped and contained within the beads, but the active ingredient is capable of being released. It is also possible to use a volatile liquid during polymerization and to subsequently thermally drive off the volatile liquid, leaving behind a porous polymer bead product into which a variety of active materials can be subsequently adsorbed.
Examples of polyunsaturated monomers suitable for use in accordance with the present invention are ethylene glycol dimethacrylate, triethylene glycol dimethacrylate, tetraethylene glycol dimethacrylate, trimethylol propane ethoxylated triacrylate, ditrimethylol propane dimethacrylate; propylene, dipropylene and higher propylene glycols, 1,3 butylene glycol dimethacrylate, 1,4 butanediol dimethacrylate, 1,6 hexanediol dimethacrylate, neopentyl glycol dimethacrylate, pentaerythritol dimethacrylate, dipentaerythritol dimethacrylate, bisphenol A dimethacrylate, divinyl and trivinyl benzene, divinyl and trivinyl toluene triallyl maleate, triallyl phosphate, diallyl maleate,' diallyl itaconate and allyl methacrylate. The mono-unsaturated monomers include allyl methacrylates and -17- 203082~
-acrylates having straight or branched chain alkyl groups with 1 to 30 carbon atoms, preferably 5 to 18 carbon atoms.
Preferred monomers include lauryl methacrylate, 2-e~hylhexyl methacrylate, isodecylmethacrylate, stearyl methacrylate, hydroxy ethyl methacrylate, hydroxy propyl methacrylate, diacetone acrylamide, phenoxy ethyl methacrylate, tetra-hydrofurfuryl methacrylate and methoxy ethyl methacrylate.
As noted previously, the copolymer can be formed by copolymerizing one monounsaturated monomer with one polyunsaturated monomer or with only polyunsaturated monomers.
EXAMPLE IV
Example I was repeated for each of a series of monomer systems shown in Tables IV-XVII. In each instance, submicron sized copolymeric powders were produced employing a stirring speed of about seventy-five RPM. The catalyst was benzoyl peroxide. Adsorption capacities of the various copolymeric powders for fluids were determined and are shown in the Tables, along with the mole ratios of monomers and the solvent. The abbreviations used in Tables IV-~VII are identified as follows:
DAA Diacetone a~rylamide EGDM Ethylene glycol dimethacrylate TEGDM Tetraethylene glycol dimethacrylate ST Styrene DVB Divinylbenzene VP Vinyl pyrrolidone IBOMA Isobornyl methacrylate PEMA Phenoxyethyl methacrylate IDMA Isodecyl methacrylate STMA Stearyl methacrylate HPMA Hydroxypropyl methacrylate CYMA Cyclohexyl methacrylate ~0~9 DMAEMA Dimethylaminoethyl methacrylate TBAEMA t-butyl aminoethyl methacrylate AMPS 2-acrylamido propane sulfonic acid BMA Butyl methacrylate EHMA 2-ethylhexyl methacrylate MMA Methyl methacrylate HEMA 2-hydroxyethyl methacrylate EH0 2-ethylhexyl oxystearate GG Glucose glutamate IPA Isopropyl alcohol PEG Polyethylene glycol 200 TABLE IV
Adsorption Capacity %
Mole Monomers Ratio Solvent EHO Glycerine GG Water DAA/EGDM 20/80 Xylene 75 82 83 78 DAA/EGDM 30/ 70 Xylene 77 80 83 78 DAA/EGDM 40/60 Xylene 75 75 83 77 DAA/EGDM 50/50 Xylene 50 57 67 0 DAA/EGDM 60/40 Xylene 40 40 50 0 DAA/TEGDM 20/80 Xylene 40 50 62 58 DAA/TEGDM 30/ 70 Xylene 29 40 50 55 DAA/TEGDM 40/60 Xylene 25 28 40 43 DAA/TEGDM 50/50 Xylene 25 30 40 43 DAA/TEGDM 60/40 Xylene 22 29 40 40 ~.. '~
C~
G~
2 ~ ' 29 oo ~ ~ o o o o o o o o 0~
h a~ ~ co O O u~ u~ I~ I~ r~ ~D O
Cr o ~~
~,1 ~ ~ ~ rJOoo ~ ~ I~ ~ r~ ~ O
r~1 C~
~: ~ I Oooo C~l ~ O O ~ O u~ ~ ~ O
u~ H H H H H H H H H H H H H 1-1 O O O O O O O O O O O O O O O
r~ 4 o ~ o o o o o o o o O O O o O o L L L L L L L
TABLE VI
Adsorption Capacity %
Monomers Ratio Solvent EH0 Glycerine GG Water VP/EGDM 20/80 Xylene 77 80 74 73.6 VP/EGDM 30/70 Xylene 76 79 78.3 70 VP/EGDM 40/60 Xylene 70 67 75.6 75 VP/EGDM 50/50 Xylene 72 76 80 76 VP/EGDM 60/40 Xylene 74 80 76 77 VP/TEGDM 20/80 Xylene 58 68.8 61.5 67.7 VP/TEGDM 30/70 Xylene 70 67 54.5 68.8 VP/TEGDM 40/60 Xylene 54.5 61.5 52.4 64.3 VP/TEGDM 50/50 Xylene 44.4 47.4 52.4 52.4 VP/TEGDM 60/40 Xylene 50 44.4 50 54.4 VP/TEGDM 70/30 Xylene 50 47.4 44.4 50 ~3 VP/TEGDM 80/20 Xylene 54.5 52.4 60 58 ~3 -q ~
o o o o o o o o o o o o o o ~ ~l~ u) ~ ~ ~ u~~D ~I~u~ r~
r C~r~1~r~0~ 0 1~ ~ r~ O r~ ~ ~ r~
t ~J
o . . . . . . . . . . . .
~ r~ ~ ~D ~ O r~
r~
rC!~
0~ ~~001~0 0C~~Dr;
~
U~H H H H H H H H H H H H H H
O O O O O O O O O O O O O O O
r~ ~
O ~ O O O O O O O O O O O O O O
L LLL L L L
a) O ~ C _ C _ C C r O
o : m : : : ~
-- H------1~ --1------ H
2 ~
a ~ ~ . . . . . .
,~ o o o o 0 c~
J~ ~
~ O O ~ ~Dr~ ~ ~ ~ c~ ~D
L
~J
g a~
. . . . . . . . . . . .
X O~ ~ 0 ~ 0 ~D O1~ 0 ~ 0 :> ~~~ ~ D 0 ~ ~~D 0 0 1 a~
U~H H H H H H H H H H H H H H
COOOOOOO OOOOOOO
o~ooooooo ooooooo D 1~ 0 ~ ~ ~u~ ~ 0 ~ _ _ _ _ _ _ -- - , _ _ .
CQ5 ; 5 5 5 .5 5 . ~ ~
L L L~L L L L
E -- --o o o o o o o o o o r~.
h o ~ ~ I~ a~ o c~ ~ O O
~, g a~
O ~ o c~ ~ ~ u ~, ,~
C~
O u~ 0 o 0 0 c~ O ~ 0 0 ,~ ¢ ~ ¢
O P~ ~ ~ ~ ~ ~ ~ ~ P ~
u~ H H H H H H H H H H
O o o o O O O O O O O
,~ 4 O r O O O O O O o O O O
u~ -i 3 ~ L L ~ L L
~Ll Ll ~1 - -E-l - -f -- -- --~o ~
~ ~ H 1-1_ 1_ ~ ~ ~ ~ ~
2~
o o o o o o o o o h I~ u~ u~ ~ ~ ~ ~ u~
C~
~r ~ ~D Irl r l 00 C~l C~ O 00 ~D
L
O
j~ .,1 . ... ...
r l C~
P~ ~ ~
01 ~ ~ IJ'l r-l ~ O O ~ 1 o O ~ ~ ~ ~ ~ ~ ~ ~ ~
U~ H H H H H H H H H
C O O O O O O O O O
~U ~r a~ 0 1~ ~D ~)O~ I~ ~O U') r-l ~
O ~ O O O O O O O O O
,~
3 3 L L ~ L
Ei -- -- --O ~
2 ~ 9 ~, . . . .
~ ~ O O O O O O_I O~ ~D ~ O
~~ ~ _1 00 C~ O 001~ 00 ~ O
L
~r ~, ~, ~, . . . . . . . . . . . .
P
~.~
K 0~ ~ ~ ~r~ ~ o ~1 o~D o c~ ~ ~ o ~I
r~ r~r~ ~r~_~r~_I r~r~r~_Ir~r~r~
O h h hh h h h hh h h h h h X P~ xPq xPCPC xP~ PC
G O O OO O O O OO O O O O O
~-r 0 ~ ~DU~ ~ ~ ~~ t~~D
r~ ~
O ~ O O OO O O O OO O O O O O
;.~ LL L L L L L
~ ~ $ ~ X ~
g ~ 9 ~a~ ~
~. o o o o o o ~ o o o o o o o ~ .
b~
C~
t_ r ~J
O
~ O O O O O O O
H Ir) u) c~
O
~ ~ O ~ ~ ~ ~ ~ I ~ O ~ ~1 U~ H H H H H H H H H H H H H H
O O O O O O O O O O O O O O
O ~ O O O O O O O O O O O O O O
~q 5 5 ; 5 -5 5 5 h ~ L L L L L L L
~0 ;~ ;~; g g, g g. g, ~ g -g' g g g g o ~ 0~ 0 ~Dr~l O O
V) 4~:) ~ ~ ~ ~ . . . .
~rO ~D O C~ 00 u~ c~00 ~~0 n~ r-1 C~
~rl OO
4r~l. . . . . . . .
'4 c~ 0~r~l r-l 0 0~D r~
~ a ~ S
H
H ~ I~<r~I~
H ~1~ ~ . .
X ~ O~I~ ~ O O O O
00 ~v ' O
U~ _ _ -- -- _ -- -- -- _ O O O O O O O O O O
a~-r o r~l 4 O ~ O O O O O O O O O
r~; r; ; r; r; ; ; r; r;
vl h a~
O S. S ~ ~ S ~ S
o ~ a 2 ~
~ 0~~D 00 t~
o $ ~ oo o ~, ~ oo 00 ~D1~ ~D r~ u~
a~
._1 r~
h ~ ~ ~ o ,1 L ~
c ~~1 o O
. . . . .
O O~D c~l S 0~
n a .. ..
:>
H S ~
K a ~ o o o o o ~, C a~ aa ~ o ~ a a~
a~ ~ h ~ ~I y Y OX K
O h '' cn K _ -- ~1~:_ _ o o o o o o a~- oo x ~
~ IJ
O cr o o o o o o a~
o u~
C ~
.~ a ~ g ~ r~
o ~ . . .
:r: ~ ~ o ~ o o o a h l t~ I~ I~ r.~ ~ r,~-) r~
,~ ~ . . . . . .
~r ~ D r~o r,r r-l ~r r~
~rl O O
r ~rl P~ ~
O O O O O OO
O ~:
O ¢ ¢ ¢ ¢ ¢ ¢ ¢
rJ~ H H H H HH H
G O O O O OO O
r~ I
o ~r o o o o oo o -5 -5 ~ -55 o~
g _ ~5i '.~9 ~ ~ U~ ~ Y~
o I oo ~ ~ a~
u~
a) . ,, ~L~ ~ . . . . . .
~r L C~
~J
~~
o O
~ J o _~
o a P~ a 0 ~
~ ~ ~, .
o P~ ~ P~ ~ ~ ~ ~
U~ H H H H H H H
O O O O O O O O
O cr O O O O O O O
cq--------___ 5 5 ~ ~ ~
3 ~ ;~
O
u~
o :~:
~ u~
h ~rl ~, a~ . . . . . .
U ~ oo ~ ~ ~ o~ ~
~' h u~ u ) ~D ~ ~ ~ ~D
L
o . ~ U~ ~ U~ U~
,~ ,~ ~ ~ oo H
H
:' a, . .. . . .
-I 'C ~ ~ ~ ¢ 'C
0 ~4 ~ ~ ~ ~ P~ ~
U~ H H H H H H H
O O O O O O O O
~1 ~
o ~r o o o o o o o 5~S' ' --h ~o ~
I' d The water adsorbing porous polymeric materials produced above in some instances are to be contrasted with the water containing beads of U.S. Patent No. 3,627,708, issued December 14, 1971. The bead of the '708 patent is produced by "in situ" suspension polymerization and is adapted to contain water only because of the presence of a solubilizer such as sodium bis(2-ethyl hexyl) sulfosuccinate.
The materials of Example IV, on the other hand, are produced by a precipitation polymerization process, which contains no solubilizer and produces a material in the form of a powder consisting of unit particles, agglomerates and aggregates.
Thus, these materials are very distinct from the materials of the '708 patent.
The particulates of the present invention can be used as a carrier and the particulate carrier means can be in the form of micron-sized beads or the particulate carrier means can be in the form of a powder. In the latter case, the powder constitutes a combined system of particles, the system of powder particles including unit particles of a size less than about one micron in average diameter, agglomerates of fused unit particles of sizes in the range of about twenty to about eighty microns in average diameter and aggregates of clusters of fused agglomerates of sizes in the range of about two hundred to about twelve hundred microns in average diameter.
As noted above, highly crosslinked, polymeric systems consisting of particles of submicron size, can be prepared from monomers having at least two polymerizable unsaturated bonds and containing no comonomers having monounsaturated moiety. These highly crosslinked systems can adsorb large quantities of active substances even of very different structures and properties.
2 ~
Examples of such monomers are bis or poly acrylates, methacrylates or itaconates of ethylene glycol, propylene glycol, di-, tri-, tetra-, polyethylene glycol and propylene glycol, trimethylol propane, glycerine, erythritol, xylitol, pentaerythritol, di-pentaerythritol, sorbitol, mannitol, glucose, sucrose, cellulose, hydroxy cellulose, methyl cellulose; 1,2 and 1,3-propanediol; 1,3 and 1,4-butanediol, 1,6-hexanediol, 1,8-octanediol and cyclohexanediol and triol. Similarly, bis acrylamido or methacrylamido compounds can be used, such as methylene bis acryl or methacrylamide, 1,2-dihydroxy ethylene bis-acryl or methacrylamide and hexamethylene bis-acryl or methacrylamide.
Another group of monomers are represented by di or poly vinyl esters such as divinyl oxalate, malonate, succinate glutarate, adipate, sebacate, divinyl maleate, fumarate, citraconate and mesaconate.
Still another group of monomers is represented by di or poly vinyl ethers of ethylene, propylene, butylene, glycols of glycerine, pentaerythritol, sorbitol, divinyl ether, di or poly-allyl compounds based on glycols and glycerine or combinations of vinyl allyl or vinyl acryloyl compounds such as vinyl methacrylate, acrylate, allyl methacrylate, acrylate and methallyl methacrylate, acrylate.
Aromatic, cycloaliphatic or heterocyclic monomers such as divinyl benzene, toluene, diphenyl, cyclohexane, trivinyl benzene, divinyl pyridine and piperidine, can also be used.
The polymerization is achieved by the use of a variety of free radical initiators which can be azo compounds, a peroxy dicarbonate, a peroxy ester or a sulfonyl acid peroxide. Illustrative of free radical initiators in the process are 2,2'-azobis(2,4-dimethyl-4-methoxy valeronitrile), benzoyl peroxide, 2,2'-azobis-(2,4-dimethylvaleronitrile), 2,2'-azobis (isobutyronitrile), 2-t-butylazo-2-cyano-4-methoxy-4-methylpentane, acetyl peroxide, 2-t-butylazo-2-cyano-4-methylpentane, 2,4-dichloro-benzoyl peroxide, p-chlorobenzoyl peroxide, decanoyl~' peroxide, diisononanyl peroxide, lauroyl peroxide, propinoyl peroxide, bis(4-t-butyl cyclohexyl) peroxy dicarbonate, di(sec-butyl) peroxy dicarbonate, diisopropyl peroxy carbonate, di(n-propyl) peroxy carbonate, di(2-ethylhexyl) peroxy carbanate, di(2-phenoxyethyl) peroxy carbonate, t-amyl peroxy pivalate, t-amyl pel~iv~late, t-butyl peroxyacetate, t-butyl pero~yi~obut~rate, t-butyl peroxypivalate, t-butyl peroxy neotecanonate, t-amyl perneodecanonate, cumyl perneodecanonate, cumylperpivalate, 2,5-dimethyl-2,5-bis(2-ethyl ~Y~nQyl peroxy) hexane, t-butylperoxy-2-ethyl-hexanoate, t-amyl peroxy (2-ethylhexanoate) and acetyl cyclohexyl sulfonyl peroxide.
Illustrative redox initiators are methylbutyl amine, bis(2-hydroxyethyl)butyl amine, butyldimethyl amine, dimethyl amine, dibenzylethyl amine, diethylmethyl amine, dimethylpentyl amine, diethyl amine, 2,21,2"-trihydroxy dipropyl ethyl amine, di-n-propylene amine, 2,2',2"-trimethyl tributyl amine, triethyl amine, dimethyl aminoacetal, pentylhexyl amine, triethanolamine, trihexyl amine, trimethyl amine, trioctadecyl amine, tripropyl amine, trisopropyl amine, tetramethylene diamine and esters of para-amino benzoic acid, e.g., p-dimethyl amino-2-ethylhexyl-benzoate, dimethyl aminoethyl acetate, 2-(n-butoxy)ethyl 4-dimethyl-aminobenzoate, 2-(dimethylamino) ethyl benzoate, ethyl-4-dimethylaminobenzoate, methyldiethanolamine, dibutyl amine, N,N-dimethylbenzylamine, methylethyl amine and dipentyl amine.
The plastic material in which the polymer '' containing the entrapped insect repellent is incorporated may constitute any of a wide variety of thermoplastic or ., thermosetting resins, with the proviso that the chemical repellent composition be compatible with the material selected. The resins may be in the form of pellets, granules and powders. Exemplary materials are polyoxymethylene, acrylics, cellulosics, fluoroplastics, nitrile resins, Nylons, polyamide-imides, polyarylates, polybutylene, polycarbonates, polybutylene terephthalate, polyethylene terephthalate, polyetherimides, polyethylene, ethylene-ethyl-acrylate, polymethylpentene, polypropylene, acrylonitrile-butadiene-styrene, acrylic-styrene-acrylonitrile, polystyrene, styrene-acrylonitrile, styrene-butadiene, sulfone based resins, thermoplastic elastomers, vinyl based resins, epoxies, phenolic resins and polyesters.
In the case of thermoplastic resins, the polymer containing the entrapped insect repellent is incorporated into the resin during the extrusion process. If other processes are used such as coating, molding, thermoforming or calendering, the polymer containing the entrapped insect repellent is incorporated into the resin during such processes. In the case of thermosetting resins, the polymer is incorporated during the compression molding operation. It is preferable to incorporate the polymer into the resin prior to melt processing in order to insure a uniform dispersal in the resin matrix. The resins can then be blown or cast into film, injection or blow molded or extruded. The effective-ness of products so produced will vary from a period of days in the case of thin films to years in compression molded wall panels. The polymer may also be incorporated into reinforced types of resins, if desired. The insect repellent may be entrapped into the macroporous polymer bead or powder of the present invention in accordance with the procedures of 203082~
Example I or II in the case of a powder form or Example III
in the case of the bead form.
For purposes of the present invention, t~ë term "unexpanded" is intended to mean plastics other than cellular materials containing an appreciable fraction of uniformly dispersed voids or cells whether classified as open-celled or closed-celled. Thus, open foams of the type in U.S. Patent No. 4,828,542, issued May 9, 1989, would not be included among the types of plastic materials intended under the present invention.
As noted previously, the preferred chemical for use as the insect repellent is N,N-diethyl-m-toluamide, commonly referred to as DEET. Other repellent chemicals that may be employed include, for example, dimethyl phthalate; Rutgers 6-12 2-ethyl-1,3-hexanediol; ~Stabilene"~, MGK Repellent 326, Indalone; dibutyl phthalate; MGK Repellent 11; Citronyl;
alicyclic piperidines; Permethrin; dibutyl succinate;
hexahydrodibenzofuran carboxaldehyde-butadiene-furfural copolymer; tert-butyl N,N-dimethyldithiocarbamate;
2-hydroxyethyl n-octyl sulfide; pyrethrins; ~iazinon;
Aldicarb; pine oil; and anthrahydroquinones. Such chemicals are effective against various categories of mo~quitos, ticks, chiggers and cockroaches.
The following examples illustrate the concept of the present invention.
EXAMPLE V
Into a mixing bowl was placed ten grams of the powder of Example I. To the powder was added forty grams of liquid insecticide diethyltoluamide. The mixture was blended with a spoon until uniform. The powder readily absorbed the liquid insecticide, entrapping the insecticide therein 'and yet r~ ~;ning free flowing. The powder with the entrapped insecticide therein is suitable for incorporation into resin ~Trade mark ,....
?~' Og~
matrices for the production of insect repelling articles of manufacture. Larger quantities of the powder containing the entrapped insecticide may be produced by employing a Patterson-Kelly Twin Cone Blender.
EXAMPLE VI
A four liter polymer kettle containing two-hundred milliliters of distilled water and two-hundred milliliters of pine oil was flushed with nitrogen. The solution was mixed and the temperature raised to approximately 85~C. To the kettle was added five-hundred milliliters of twenty percent by weight of divinylbenzene, five percent by weight of benzoyl peroxide and the remainder styrene. After thirty minutes, the polymerization ceased and the polymer bead entrapping the pine oil insecticide was collected by filtration.
EXAMPLE VII
A mixture of finely ground sulfonated styrene-divinylbenzene polymer containing fifteen percent divinyl-benzene and polyethylene pellets was heated to 180~C., kneaded in a mixture and pelletized to one sixteenth of an inch pellets. The pellets were fed to a screw extruder.
Prior to extrusion into one mil sheets, particles of insecticide entrapped styrene-divinylbenzene beads prepared in accordance with Example VI were added. The resulting sheets were cut into strips and used as animal collars and as insecticidal strips in homes and restaurant establishments.
While the foregoing disclosure specifies various uses of the materials of the present invention, as well as various types and compositions of ingredients which may be entrapped within these and similar materials, the patent literature is replete with uses and ingredients which may be entrapped in these and similar materials. For example, U.S.
Patent No. 4,690,825, discloses as active ingredients ~~ ~39~ 2 0 3 0 8 2 q lubricants, emollients, moisturizers, pigments, insect or flea repellents, fragrances, vitamins and drugs. When the active ingredient is a drug, it is said to include~
anti-infectives such as antibiotics, fungicides, scabicides, pediculicides, iodine, anti-inflammatory agents, antipruritics, astringents, anti-hidrotics, keratolytic agents, caustics. keratoplastic agents, rubefacients, sunscreens, demulcents, protectants and detergents. Uses of loaded beads includes cosmetic preparations such as hand creams, acne products, deodorants, antiperspirants, baby powders, foot powders, body powders, lip ices, lip sticks, baby creams and lotions, mouthwashes, dentifrices, medicated facial creams and lotions, shampoos, shaving creams, pre- and after-shave lotions, depilatories and hairgrooming preparations.
U.S. Patent No. 4,724,240, names as active ingredients ethylhexyl oxystearate, arachidyl propionate, ethylhexyl adipate, isopropyl myristate, ethanol, stearyl alcohol, propylene glycol, propionic acid, stearic acid, polyoxypropylene cetyl alcohol, ~Carbowax~*,polyethylene glycol, petroleum jelly, mineral oil, mineral spirits, lanolin, acetylated lanolin, isopropyl lanolate, hexamethyl-disiloxane, cyclic polydimethyl~iloxanes, polyphenylmethylsilo~anes, polydimethyl-trimethylsiloxanes;
phenyl, ethyl and vinyl-substituted polysilanes; and cosmetic dyes. Materials loaded with such ingredients are said to be useful in cosmetic, beauty, toiletry and healthcare products, insecticides, disinfectants, flavors, perfumes, antiperspirant wax or oil base sticks, deodorants, colognes, pressed powders and toilet soaps.
Entrapped functional materials in the Published European Application No. 0252463A2 published January 13, 1988, are said to encompass pigments, perfumes, pheromones, ~Trade mark '2~
-synthetic insect attractants, pesticides including juvenile hormone analogs, herbicides, pharmaceuticals, antimicrobial agents, sunscreens, light stabilizers, fragrances, flavors including sweeteners and various chemicals. Of the various chemicals disclosed are menthol, soybean oil, Vitamin E, salicylic acid, squalane, simethicon, bromochlorinated paraffin, benzophenone, petroleum distillate, jojoba oil and citrus oil. The published application also specifically identifies and names four pheromones, twenty pesticides, twenty-three fragrances, about thirty-seven chemicals and some twenty-two emollients, that may be entrapped in the materials as active ingredients.
In the Patent Cooperation Treaty International Publication No. W0/88/01164, there is also listed as specifically named ingredients which may be loaded into the beads approximately twenty-two ultraviolet absorbers, nineteen insect repellants and thirty emollients. The publication also names several steroids including adrenocortical steroids such as fluocinolone, fluocinolone acetonide, triamcinolone acetonide, beta-methasone valerate, timobesone acetate, hydrocortisone, hydrocortisone acetate, triamcinolone, prednisolone, prednisolone acetate, dexamethasone, beclomethasone dipropionate, betamethasone diproprionate, betamethasone benzoate, clocorolone pivalate, halcinonide, flumethasone pivalate and desonide.
European Published Application No. 0306236A2, published March 3, 1989, discloses "in situ" and "post absorbed" suspension polymerized beads loaded with six different categories of active ingredients. The six categories of active ingredients are hair growth promoters, acne treatments, fragrances, vitamins, pain relievers and epidermal lipid substitutes. The hair ~rowth promoter is Minoxidil. For acne treatment there is employed benzoyl peroxide, salicylic acid and resorcinol. Fragrances include flower oils, essential oils, animal and synthetic fragrances and resinoids. Some thirty-nine specific fragrances are named. Vitamins include A, D, E, K, Bl, B2, B12, B15, B17, C, niacin, folic acid, panthotenic acid, biotin, bioflavinoids, choline, inositol and F. Cod liver oil and retinoids are also disclosed. Some twenty-two pain relievers and some twenty-two mixtures and combinations of various pain relievers are disclosed, among which are menthol, camphor and methyl salicylate. The epidermal lipid substitutes are squalane and squalene. The six categories of loaded beads may be used alone or as topical applications in creams, ointments, lotions and oils. In addition, the fragrance loaded beads can be added to perfumes, colognes, cosmetics, soaps, paper products, detergents and body and foot powders.
The vitamin loaded beads also find application in lip balms, lipsticks, eye shadows, foundations and blushers.
In U.S. Patent No. 4,719,040, issued January 12, 1988, a porous polymer powder laden with perfume is included as an ingredient in an aqueous air freshener gel. U.S.
Patent No. 4,764,362, issued August 16, 1988, and a divisional thereof U.S. Patent No. 4,813,976, issued March 21, 1989, relate to emery boards including an emollient entrapped onto an absorbent acrylates copolymer powder.
Filing of a nail releases the emollient which conditions and lubricates the nails and cuticles. A toothpaste containing dental flossing tape is disclosed in U.S. Patent No. 4,776,358, issued October 11, 1988. Included as an ingredient of the dentifrice are "microsponges" containing a flavor oil. In U.S. Patent No. 4,828,542, issued May 9, 1989, particles entrapping various functional materials are bonded to the surfaces of an expanded reticulated polyurethane foam. Among the enumerated functional materials 2~3~
which may be entrapped are adhesives; pharmaceuticals such as insulin, interferon, albumin, hormones and monoclonal antibodies; flavors; fragrances for perfume samplers, air fresheners and drawer liners; colors; inks; liquid crystals;
oils; waxes; solvents; resins; fire extinguishing agents;
insect repellants for mothballs and flea and tick applications; agricultural chemicals such as insecticides, fungicides and heromones; disinfectants; cosmetics such as skin lotions, hair care products, sunscreens and mouth wash;
vitamins; antiperspirants; contraceptives; medicants such as Benzocaine, transdermal drugs, analgesics, allergy bacteria, methyl salicylate and nitroglycerin.
It will be apparent from the foregoing that many other variations and modifications may be made in the structures, compounds, compositions and methods described herein without departing substantially from the essential features and concepts of the present invention. Accordingly, it should be clearly understood that the forms of the invention described herein are exemplary only and are not intended as limitations of the scope of the present invention.
Claims (18)
1. A composition comprising an unexpanded plastic resinous material having uniformly dispersed and incorporated therein discrete particles of a highly cross-linked macroporous hydrophobic polymer, the polymer having entrapped therein a chemical which is a repellent for insects, the chemical being compatible with the unexpanded plastic resinous material.
2. The composition of claim 1 wherein the polymer is formed of at least one monounsaturated monomer and at least one polyunsaturated monomer.
3. The composition of claim 2 wherein the monounsaturated monomer is lauryl methacrylate and the polyunsaturated monomer is ethylene glycol dimethacrylate.
4. The composition of claim 1 wherein the polymer is formed of at least one polyunsaturated monomer.
5. The composition of claim 4 wherein the polyunsaturated monomer is selected from the group consisting of ethylene glycol dimethacrylate and tetraethylene glycol dimethacrylate.
6. The composition of claim 3 in which the particles are in the form of a bead.
7. The composition of claim 3 in which the particles are in the form of a powder and the powder is a combined system of particles, the system of powder particles including unit particles of less than about one micron in average diameter, agglomerates of fused unit particles of sizes in the range of about twenty to eighty microns in average diameter and aggregates of clusters of fused agglomerates of sizes in the range of about two-hundred to about twelve-hundred microns in average diameter.
8. The composition of claim 3 wherein the unexpanded plastic resinous material is a thermoplastic resin.
9. The composition of claim 8 wherein the unexpanded plastic resinous material is a thermosetting resin.
10. The composition of claim 8 in which the chemical insect repellent is a compound which repels insects selected from the group consisting of mosquitos, ticks, chiggers and cockroaches.
11. The composition of claim 10 in which the insect repellent is N,N-diethyl-m-toluamide.
12. The composition of claim 11 in which the repellent constitutes from about twenty-five to about ninety percent by weight based on the weight of the repellent and the polymer.
13. The composition of claim 12 in which the repellent constitutes about eighty percent by weight based on the weight of the repellent and the polymer.
14. The composition of claim 13 in which the repellent and the polymer constitute from about one-half of one percent to about fifty percent by weight based on the weight of the composition.
15. An article manufactured from the composition of claim 1.
16. An article manufactured from the composition of claim 11.
17. The article of claim 16 which is an outdoor accessory.
18. The article of claim 17 which is an item of lawn furniture.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/463,000 US5102662A (en) | 1989-12-08 | 1989-12-08 | Insect repellent plastic |
US463,000 | 1989-12-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2030829A1 CA2030829A1 (en) | 1991-06-09 |
CA2030829C true CA2030829C (en) | 1998-02-17 |
Family
ID=23838538
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002030829A Expired - Fee Related CA2030829C (en) | 1989-12-08 | 1990-11-26 | Insect repellent plastic |
Country Status (2)
Country | Link |
---|---|
US (1) | US5102662A (en) |
CA (1) | CA2030829C (en) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5591727A (en) * | 1990-09-12 | 1997-01-07 | Perycut-Chemie Ag | Insecticidal composition |
DE9012996U1 (en) * | 1990-09-12 | 1991-10-10 | Perycut Chemie Ag | |
CA2051469A1 (en) * | 1990-09-27 | 1992-03-28 | Leslie A. Cohen | Polymer composition which masks odor |
US5256400A (en) * | 1991-12-04 | 1993-10-26 | Advanced Polymer Systems, Inc. | Pressurized product delivery systems |
DE4140273C2 (en) * | 1991-12-06 | 1995-08-17 | Stewing Nachrichtentechnik | Heat-sensitive surface coating for heat-shrinkable products, especially shrink sleeves made of thermoplastic for cable sleeves |
US6180127B1 (en) * | 1992-06-16 | 2001-01-30 | Aquasource, Inc. | Slow release insect repellents |
DE19709075A1 (en) * | 1997-03-06 | 1998-09-10 | Huels Chemische Werke Ag | Process for the production of antimicrobial plastics |
US5783502A (en) * | 1995-06-07 | 1998-07-21 | Bsi Corporation | Virus inactivating coatings |
US5859057A (en) * | 1995-09-27 | 1999-01-12 | Schwartz; Alan M. | Cockroach repellent |
CA2229522A1 (en) | 1998-04-15 | 1999-10-15 | Thomas Randall Inkpen | Needle aid |
US7343710B2 (en) * | 1998-07-03 | 2008-03-18 | I.D.A Limited | Method and apparatus for controlling pests |
GB9814507D0 (en) * | 1998-07-03 | 1998-09-02 | Univ Southampton | A method and apparatus for controlling pests |
USRE44145E1 (en) | 2000-07-07 | 2013-04-09 | A.V. Topchiev Institute Of Petrochemical Synthesis | Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties |
US7183249B2 (en) * | 2000-11-21 | 2007-02-27 | Robertet Fragrances, Inc. | Fragrance compositions and delivery systems |
US6719959B1 (en) | 2000-11-28 | 2004-04-13 | Avon Products, Inc. | Extended duration insect repellent composition and method of application to the skin |
US6969521B1 (en) | 2000-11-28 | 2005-11-29 | Avon Products, Inc. | Aerosol insect repellent composition having low VOC content and method of applying same to the skin |
FR2823138B1 (en) * | 2001-04-06 | 2007-12-21 | Aft Plasturgie | NEW ACTIVE ELEMENTS CONTAINING FIBERS, PROCESS FOR THEIR MANUFACTURE, AND THEIR APPLICATIONS IN PARTICULAR IN PACKAGING |
BE1014125A3 (en) * | 2001-04-17 | 2003-05-06 | Lawn Comfort | Odor-releasing molded plastic furniture, especially insect-repelling garden furniture, comprises an odorant dispersed in an injection-moldable polymer material |
ES2587187T3 (en) * | 2001-05-01 | 2016-10-21 | A. V. Topchiev Institute Of Petrochemical Synthesis | Biphasic water absorbent bioadhesive composition |
US8840918B2 (en) * | 2001-05-01 | 2014-09-23 | A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences | Hydrogel compositions for tooth whitening |
US20050215727A1 (en) | 2001-05-01 | 2005-09-29 | Corium | Water-absorbent adhesive compositions and associated methods of manufacture and use |
US8206738B2 (en) | 2001-05-01 | 2012-06-26 | Corium International, Inc. | Hydrogel compositions with an erodible backing member |
US8541021B2 (en) | 2001-05-01 | 2013-09-24 | A.V. Topchiev Institute Of Petrochemical Synthesis | Hydrogel compositions demonstrating phase separation on contact with aqueous media |
US20050113510A1 (en) | 2001-05-01 | 2005-05-26 | Feldstein Mikhail M. | Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components |
JP4116447B2 (en) * | 2001-05-01 | 2008-07-09 | エイ.ブイ.トップチーブ インスティテュート オブ ペトロケミカル シンセシス | Hydrogel composition |
US6749861B2 (en) * | 2001-06-29 | 2004-06-15 | Lenco Laboratories, Llc | Fragrance-containing insect repellant compositions |
DE10157350A1 (en) * | 2001-11-22 | 2003-05-28 | Stockhausen Chem Fab Gmbh | Production of controlled release plant treatment composition, comprises kneading water-absorbing polymer containing absorbed water with active agent, e.g. fungicide or insecticide |
US20050186238A1 (en) * | 2003-06-03 | 2005-08-25 | Nix, Inc. | Universal insect repellant enclosure |
JP4347611B2 (en) * | 2003-06-03 | 2009-10-21 | 株式会社ニックス | Resin products for insect repellent |
US8658201B2 (en) | 2004-01-30 | 2014-02-25 | Corium International, Inc. | Rapidly dissolving film for delivery of an active agent |
ES2526700T3 (en) * | 2004-08-05 | 2015-01-14 | Corium International, Inc. | Adhesive composition |
US20060182788A1 (en) * | 2005-01-27 | 2006-08-17 | Parminder Singh | Hydrophilic biocompatible adhesive formulations and uses |
US20080187564A1 (en) * | 2005-03-07 | 2008-08-07 | Hidekazu Momiyama | Pest-Control Member |
JP4504232B2 (en) * | 2005-03-07 | 2010-07-14 | 株式会社ニックス | Resin products for insect repellent or insecticide |
JP2007097431A (en) * | 2005-09-30 | 2007-04-19 | Nix Inc | Pest-repelling product |
US20070269472A1 (en) * | 2006-05-18 | 2007-11-22 | Osamu Igarashi | Pest-control product |
US20080035640A1 (en) * | 2006-08-10 | 2008-02-14 | Weber Marcia L | Washable trash-can cover that is secured to the can by its handles |
JP2009184556A (en) * | 2008-02-07 | 2009-08-20 | Kojima Press Co Ltd | Ceiling attachment part for cabin |
US8784879B2 (en) * | 2009-01-14 | 2014-07-22 | Corium International, Inc. | Transdermal administration of tamsulosin |
US10455832B1 (en) | 2010-10-26 | 2019-10-29 | Ecolab Usa Inc. | Compositions and methods of product application to target and kill all life stages of bed bugs |
US20150007487A1 (en) * | 2013-07-03 | 2015-01-08 | Rockwell Automation Technologies, Inc. | System and method for incorporation of pest repellent with bus bar cover components |
AU2015218677B2 (en) | 2014-02-24 | 2018-08-09 | Ecolab Usa Inc. | Bed bug trap and monitor |
ES2837094T3 (en) * | 2014-06-19 | 2021-06-29 | Ecolab Usa Inc | Composition for the detection and treatment of bed bugs |
EP3801024A1 (en) | 2018-06-04 | 2021-04-14 | Ecolab USA Inc. | Methods and compositions for preventing degradation of dimethyl trisulfide |
IT201900022440A1 (en) * | 2019-11-29 | 2021-05-29 | Federico Battaglin | PERFECT SENSOR, PARTICULARLY FIRE AND / OR ANTI-INTRUSION |
EP3835745A1 (en) | 2019-12-10 | 2021-06-16 | Veoneer Sweden AB | Door pressure sensor assembly |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2809943A (en) * | 1952-09-11 | 1957-10-15 | Dow Chemical Co | Weighted ion exchange resin granules and method of making same |
DE1745717A1 (en) * | 1957-03-09 | 1970-01-29 | Bayer Ag | Process for the production of crosslinked copolymers with a sponge structure |
NL241315A (en) * | 1958-07-18 | |||
GB1140910A (en) * | 1965-08-26 | 1969-01-22 | Permutit Co Ltd | Cross-linked porous polymers |
FR1483946A (en) * | 1966-04-28 | 1967-06-09 | Dia Prosim | Process for preparing macroporous resins, and applications thereof for obtaining ion exchangers |
DE1694240C3 (en) * | 1968-01-16 | 1973-11-29 | Bayer Ag, 5090 Leverkusen | Process for the production of insecticidally active moldings |
US3627708A (en) * | 1968-08-05 | 1971-12-14 | Sybron Corp | Macroporous cross-linked copolymers and process therefor |
US3767600A (en) * | 1968-08-30 | 1973-10-23 | Rohm & Haas | Porous polymers with ionic functional groups based on polyfunctional methacrylates |
USRE27026E (en) * | 1969-03-20 | 1971-01-12 | Preparation of porous structures | |
JPS5426396B2 (en) * | 1974-06-04 | 1979-09-04 | ||
AU1158276A (en) * | 1975-03-03 | 1977-09-08 | Airwick Ag | A solid air odor-improving agent-releasing diffuser system |
US4208309A (en) * | 1977-05-20 | 1980-06-17 | Rohm Gmbh | Pearl polymer containing hollow pearls |
US4724240A (en) * | 1981-03-23 | 1988-02-09 | Wickhen Products, Inc. | Lattice-entrapped emollient-moisturizer composition |
CA1168157A (en) * | 1981-03-23 | 1984-05-29 | Eric S. Abrutyn | Polymer entrapped emollient-moisturizer composition |
US4661327A (en) * | 1983-03-30 | 1987-04-28 | Phillips Petroleum Company | Recovery of mineral values using magnetically susceptible ion exchange agent |
NL8400516A (en) * | 1984-02-17 | 1985-09-16 | Naarden International Nv | METHOD FOR PREPARING AIR FRESHENING GELS |
US4828542A (en) * | 1986-08-29 | 1989-05-09 | Twin Rivers Engineering | Foam substrate and micropackaged active ingredient particle composite dispensing materials |
US4678684A (en) * | 1985-05-02 | 1987-07-07 | Hercules Incorporated | Method for impregnating a thermoplastic polymer |
US4690825A (en) * | 1985-10-04 | 1987-09-01 | Advanced Polymer Systems, Inc. | Method for delivering an active ingredient by controlled time release utilizing a novel delivery vehicle which can be prepared by a process utilizing the active ingredient as a porogen |
US4855127A (en) * | 1986-07-07 | 1989-08-08 | Dow Corning Corporation | Lattice-entrapped composition |
EP0277211B1 (en) * | 1986-08-15 | 1994-06-01 | Advanced Polymer Systems, Inc. | Polymeric carrier compositions and methods for their preparation and use |
US4776358A (en) * | 1986-09-23 | 1988-10-11 | Leonard Lorch | Floss employing microporous tapes sandwiching paste dentifrice |
US4813976A (en) * | 1986-10-22 | 1989-03-21 | The Cook Bates Company | Nail-conditioning emery boards and process for making them |
US4764362A (en) * | 1986-10-22 | 1988-08-16 | The Cook Bates Company | Nail-conditioning emery boards and process for making them |
ZA886284B (en) * | 1987-08-31 | 1990-04-25 | Advanced Polymer Systems Inc | Controlled release formulations |
US4806360A (en) * | 1987-10-23 | 1989-02-21 | Advanced Polymer Systems | Synthetic melanin aggregates |
-
1989
- 1989-12-08 US US07/463,000 patent/US5102662A/en not_active Expired - Lifetime
-
1990
- 1990-11-26 CA CA002030829A patent/CA2030829C/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2030829A1 (en) | 1991-06-09 |
US5102662A (en) | 1992-04-07 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2030829C (en) | Insect repellent plastic | |
US4962133A (en) | Method of making highly adsorptive copolymers | |
US5037485A (en) | Method of cleaning surfaces | |
US5208038A (en) | Coacervated highly absorptive polymers | |
US4855127A (en) | Lattice-entrapped composition | |
US4948818A (en) | Method of making porous hydrophilic-lipophilic copolymeric powders | |
AU603379B2 (en) | Polymeric carrier compositions and methods for their preparation and use | |
AU612839B2 (en) | Porous particles in preparations involving immiscible phases | |
US4724240A (en) | Lattice-entrapped emollient-moisturizer composition | |
AU640670B2 (en) | Fragrance release device containing a highly adsorptive copolymer | |
KR920003330B1 (en) | Fabric impregnated with functional substances for controlled release | |
US5145685A (en) | Skin treatment method and composition | |
US5316774A (en) | Blocked polymeric particles having internal pore networks for delivering active substances to selected environments | |
US4587129A (en) | Hydrophilic gels containing high amounts of fragrance | |
EP0061701B1 (en) | A solid entrapped emollient-moisturizer composition and the use thereof | |
CN100488990C (en) | Polymeric particles and fragrance delivery systems | |
AU619570B2 (en) | Time release protein | |
US4880617A (en) | Lattice-entrapped composition | |
EP0398538B1 (en) | Method of making hydrophilic-lipophilic copolymeric powders | |
US5281413A (en) | Antiperspirant stick containing a macroporous polymer | |
US5387411A (en) | Antiperspirant containing a hydrophobic macroporous polymer as the suspending agent | |
USRE33429E (en) | Lattice-entrapped emollient-moisturizer composition | |
EP0393510A1 (en) | Method of making highly adsorptive copolymers | |
US5126309A (en) | Decontamination of toxic chemical agents | |
JP2614132B2 (en) | Persistent air freshener |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |