CA2053924A1 - Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics - Google Patents

Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics

Info

Publication number
CA2053924A1
CA2053924A1 CA002053924A CA2053924A CA2053924A1 CA 2053924 A1 CA2053924 A1 CA 2053924A1 CA 002053924 A CA002053924 A CA 002053924A CA 2053924 A CA2053924 A CA 2053924A CA 2053924 A1 CA2053924 A1 CA 2053924A1
Authority
CA
Canada
Prior art keywords
amino acid
aeruginosa
diagnostics
immunogens
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002053924A
Other languages
French (fr)
Other versions
CA2053924C (en
Inventor
Robert S. Hodges
William Paranchych
Kok K. Lee
Sastry A. Parami
Randall T. Irvin
Peter C. Doig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Alberta
Original Assignee
Robert S. Hodges
William Paranchych
Kok K. Lee
Sastry A. Parami
Randall T. Irvin
Peter C. Doig
The Governors Of The University Of Alberta
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Robert S. Hodges, William Paranchych, Kok K. Lee, Sastry A. Parami, Randall T. Irvin, Peter C. Doig, The Governors Of The University Of Alberta filed Critical Robert S. Hodges
Priority to CA002443232A priority Critical patent/CA2443232A1/en
Publication of CA2053924A1 publication Critical patent/CA2053924A1/en
Application granted granted Critical
Publication of CA2053924C publication Critical patent/CA2053924C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Treatment and diagnosis of P. aeruginosa infection or colonization is achieved in accordance with this invention by the discovery of a polypeptide which is smaller than the naturally occurring P.
aeruginosa pilin protein. The pure polpeptide com-prises at teast one amino acid residue sequence containing about twelve amino acid residues and up to about twenty amino acid residues that define a sequence capable of immunologically mimicking an antigenic determinant site of P. aeruginosa pilin. This amino acid residue sequence can repeat as a unit one or more times in the same polypeptide motecute. More than one of such re-peating units and more than one repeating unit of the same type can be present in a single polypeptide molecule: The polyep-fides act as antigens or immunogens and antibodies may be raised to the immunogens and a vaccine prepared suitable for the prevention of P. deruginosa infection:
CA002053924A 1989-04-28 1990-04-26 Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics Expired - Fee Related CA2053924C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002443232A CA2443232A1 (en) 1989-04-28 1990-04-26 Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34456589A 1989-04-28 1989-04-28
US344,565 1989-04-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002443232A Division CA2443232A1 (en) 1989-04-28 1990-04-26 Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics

Publications (2)

Publication Number Publication Date
CA2053924A1 true CA2053924A1 (en) 1990-10-29
CA2053924C CA2053924C (en) 2003-10-21

Family

ID=23351056

Family Applications (3)

Application Number Title Priority Date Filing Date
CA000605503A Expired - Fee Related CA1340530C (en) 1989-04-28 1989-07-12 Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics
CA002443232A Abandoned CA2443232A1 (en) 1989-04-28 1990-04-26 Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics
CA002053924A Expired - Fee Related CA2053924C (en) 1989-04-28 1990-04-26 Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA000605503A Expired - Fee Related CA1340530C (en) 1989-04-28 1989-07-12 Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics
CA002443232A Abandoned CA2443232A1 (en) 1989-04-28 1990-04-26 Synthetic pseudomonas aeruginosa pilin peptide and related vaccines and diagnostics

Country Status (9)

Country Link
US (2) US5445818A (en)
EP (1) EP0469045B1 (en)
JP (1) JP2963536B2 (en)
AT (1) ATE107313T1 (en)
AU (1) AU5533490A (en)
CA (3) CA1340530C (en)
DE (1) DE69010001T2 (en)
DK (1) DK0469045T3 (en)
WO (1) WO1990013563A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629295B2 (en) 1994-07-25 2009-12-08 Roche Diagnostics Gmbh Determination of a specific immunoglobulin using multiple antigens

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5494672A (en) * 1989-04-28 1996-02-27 S.P.I. Synthetic Peptides Incorporated Pseudomonas peptide composition and method
US5223604A (en) * 1991-06-25 1993-06-29 S.P.I. Synthetic Peptides Incorporated Pseudomonas exoenzyme s peptide composition and method
US6872398B2 (en) * 1995-12-22 2005-03-29 The United States Of America As Represented By The Secretary Of The Army Conjugate vaccine against gram-negative bacterial infections
US6270777B1 (en) * 1996-12-20 2001-08-07 University Technologies International Inc. Conserved metalloprotease epitopes
US7314632B1 (en) * 1997-07-11 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Pseudomonas exotoxin A-like chimeric immunogens
US20030054012A1 (en) * 2000-05-12 2003-03-20 Fitzgerald David J. Pseudomonas exotoxin a-like chimeric immunogens for eliciting a secretory iga-mediated immune response
ATE307208T1 (en) * 1997-07-11 2005-11-15 Us Gov Health & Human Serv PSEUDOMONAS EXOTOXIN-A-LIKE CHIMERIC IMMUNOGENS
WO1999065511A2 (en) * 1998-06-12 1999-12-23 The Governors Of The University Of Alberta Composition and method for treatment of pseudomonas infection
US20030228324A1 (en) * 1999-05-06 2003-12-11 Malcolm Andrew J. Peptide compositions and methods of producing and using same
US6863896B1 (en) * 1999-10-26 2005-03-08 Chiron Corporation Plant lectins as mucosal adjuvants
WO2002060935A2 (en) * 2000-12-21 2002-08-08 The Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services A chimeric protein comprising non-toxic pseudomonas exotoxin a and type iv pilin sequences
US7132101B2 (en) * 2002-02-27 2006-11-07 Duquesne University Of The Holy Ghost Compositions and methods for eliciting an immune response to gram-negative bacterial infections
CA2583226A1 (en) 2004-10-04 2006-04-20 Trinity Biosystems, Inc. Methods and compositions for immunizing against pseudomonas infection
WO2007089272A2 (en) 2005-07-22 2007-08-09 The Regents Of The University Of Colorado, A Body Corporate Non-toxic biofilm inhibitor
WO2011094363A2 (en) 2010-01-26 2011-08-04 The Regents Of The University Of Colorado Influenza virus compositions and methods for universal vaccines
BR112016021383A2 (en) 2014-03-24 2017-10-03 Genentech Inc METHOD TO IDENTIFY A PATIENT WITH CANCER WHO IS LIKE OR LESS LIKELY TO RESPOND TO TREATMENT WITH A CMET ANTAGONIST, METHOD TO IDENTIFY A PATIENT WITH PREVIOUSLY TREATED CANCER, METHOD TO DETERMINE THE EXPRESSION OF THE HGF BIOMARKER, ANTI-C-MET ANTAGONIST AND ITS USE, DIAGNOSTIC KIT AND ITS PREPARATION METHOD
CA3066026A1 (en) 2017-06-14 2018-12-20 Virometix Ag Cyclic peptides for protection against respiratory syncytial virus
WO2020127728A1 (en) 2018-12-20 2020-06-25 Virometix Ag Lipopeptide building blocks and synthetic virus-like particles
EP4216992A1 (en) 2020-09-28 2023-08-02 DBV Technologies Particle comprising an rsv-f protein for use in rsv vaccination

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0048422A3 (en) * 1980-09-15 1983-08-24 Bactex Incorporated Pili of pseudomonas aeruginosa and utilization of same as vaccines against infectionary p.aeruginosa
US4443549A (en) * 1981-10-19 1984-04-17 Molecular Genetics, Inc. Production of monoclonal antibodies against bacterial adhesins
US4886663A (en) * 1983-01-03 1989-12-12 Scripps Clinic And Research Foundation Synthetic heat-stable enterotoxin polypeptide of Escherichia coli and multimers thereof
AU577045B2 (en) * 1983-07-23 1988-09-15 Zahnradfabrik Friedrichshafen Ag Pressure medium control device
DK219084D0 (en) * 1984-05-02 1984-05-02 Frederik Carl Peter Lindberg ANTIGEN
CA1256370A (en) * 1984-02-24 1989-06-27 Yuzuru Homma Toxoids of elastase of pseudomonas aeruginosa origin
US4702911A (en) * 1985-09-27 1987-10-27 Immunomed Corporation Preparation of bacterium pili subunits and vaccines containing pili subunits
CA1319101C (en) * 1986-09-03 1993-06-15 Marta Iris Sabara Rotavirus nucleocapsid protein with or without binding peptides as immunologic carriers for macromolecules
JP2635742B2 (en) * 1986-12-22 1997-07-30 トリオン、フォルスクニング‐オホ、ウトベクリングス、アクチェボラーグ Novel polypeptide and its use
US5494672A (en) * 1989-04-28 1996-02-27 S.P.I. Synthetic Peptides Incorporated Pseudomonas peptide composition and method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629295B2 (en) 1994-07-25 2009-12-08 Roche Diagnostics Gmbh Determination of a specific immunoglobulin using multiple antigens

Also Published As

Publication number Publication date
US5445818A (en) 1995-08-29
EP0469045B1 (en) 1994-06-15
CA1340530C (en) 1999-05-04
DE69010001D1 (en) 1994-07-21
ATE107313T1 (en) 1994-07-15
JPH04504719A (en) 1992-08-20
CA2053924C (en) 2003-10-21
JP2963536B2 (en) 1999-10-18
WO1990013563A1 (en) 1990-11-15
AU5533490A (en) 1990-11-29
DK0469045T3 (en) 1994-09-26
EP0469045A1 (en) 1992-02-05
US5612036A (en) 1997-03-18
CA2443232A1 (en) 1990-10-29
DE69010001T2 (en) 1994-09-22

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Legal Events

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EEER Examination request
MKLA Lapsed