CA2056066A1 - A physical form of n-[4-[5-(cyclopentyloxycarbony)amino-1-methylindol-3yl-methy1]-3-methoxybenzoy1]-2-methlbenzenesulphonamide, processes for its preparation and compositions containing it - Google Patents

A physical form of n-[4-[5-(cyclopentyloxycarbony)amino-1-methylindol-3yl-methy1]-3-methoxybenzoy1]-2-methlbenzenesulphonamide, processes for its preparation and compositions containing it

Info

Publication number
CA2056066A1
CA2056066A1 CA002056066A CA2056066A CA2056066A1 CA 2056066 A1 CA2056066 A1 CA 2056066A1 CA 002056066 A CA002056066 A CA 002056066A CA 2056066 A CA2056066 A CA 2056066A CA 2056066 A1 CA2056066 A1 CA 2056066A1
Authority
CA
Canada
Prior art keywords
physical form
methylindol
amino
preparation
methlbenzenesulphonamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002056066A
Other languages
French (fr)
Other versions
CA2056066C (en
Inventor
James J. Holohan
Ieuan J. Edwards
Robert J. Timko
Randy J. Bradway
Arlene Clements
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
James J. Holohan
Ieuan J. Edwards
Robert J. Timko
Randy J. Bradway
Arlene Clements
Imperial Chemical Industries Plc
Zeneca Limited
Syngenta Limited
Astrazeneca Uk Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26298105&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2056066(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB909027014A external-priority patent/GB9027014D0/en
Priority claimed from GB919115107A external-priority patent/GB9115107D0/en
Application filed by James J. Holohan, Ieuan J. Edwards, Robert J. Timko, Randy J. Bradway, Arlene Clements, Imperial Chemical Industries Plc, Zeneca Limited, Syngenta Limited, Astrazeneca Uk Limited filed Critical James J. Holohan
Priority to CA002319308A priority Critical patent/CA2319308C/en
Publication of CA2056066A1 publication Critical patent/CA2056066A1/en
Application granted granted Critical
Publication of CA2056066C publication Critical patent/CA2056066C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/40—Nitrogen atoms, not forming part of a nitro radical, e.g. isatin semicarbazone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

The invention provides a pharmaceutical composition comprising a particular physical form of N-[4-[5-(cyclopentyloxy-carbonyl)amino-1-methylindol-3-yl-methyl]-3-methoxybenzoyl]-2-methyl-benzenesulphonamide and polyvinylpyrrolidone. It also provides methods for preparing this physical form, and another physical form of N-[4-[S-(cyclopentyloxycarbonyl)amino-1-methylindol-3-yl-methyl]--3-methoxybenzoyl]-2-methylbenzenesulphonamide useful in the preparation of the first mentioned physical form. The compositions are useful in the treatment of diseases in which leukotrienes are implicated, for example asthma.
CA002056066A 1990-12-12 1991-11-22 A physical form of n-[4-[5-(cyclopentyloxycarbony)amino-1-methylindol-3yl-methy1]-3-methoxybenzoy1]-2-methlbenzenesulphonamide, processes for its preparation and compositions containing it Expired - Lifetime CA2056066C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002319308A CA2319308C (en) 1990-12-12 1991-11-22 Pharmaceutical agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB909027014A GB9027014D0 (en) 1990-12-12 1990-12-12 Pharmaceutical agents
GB9027014.1 1990-12-12
GB9115107.6 1991-07-12
GB919115107A GB9115107D0 (en) 1991-07-12 1991-07-12 Pharmaceutical agents

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002319308A Division CA2319308C (en) 1990-12-12 1991-11-22 Pharmaceutical agents

Publications (2)

Publication Number Publication Date
CA2056066A1 true CA2056066A1 (en) 1992-06-13
CA2056066C CA2056066C (en) 2002-04-02

Family

ID=26298105

Family Applications (2)

Application Number Title Priority Date Filing Date
CA002319308A Expired - Lifetime CA2319308C (en) 1990-12-12 1991-11-22 Pharmaceutical agents
CA002056066A Expired - Lifetime CA2056066C (en) 1990-12-12 1991-11-22 A physical form of n-[4-[5-(cyclopentyloxycarbony)amino-1-methylindol-3yl-methy1]-3-methoxybenzoy1]-2-methlbenzenesulphonamide, processes for its preparation and compositions containing it

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002319308A Expired - Lifetime CA2319308C (en) 1990-12-12 1991-11-22 Pharmaceutical agents

Country Status (30)

Country Link
US (6) US5319097A (en)
EP (1) EP0490648B1 (en)
JP (1) JP2585495B2 (en)
KR (2) KR0183027B1 (en)
CN (2) CN1043405C (en)
AP (1) AP285A (en)
AT (1) ATE131048T1 (en)
AU (1) AU656157B2 (en)
BE (1) BE1004229A5 (en)
CA (2) CA2319308C (en)
CZ (1) CZ283181B6 (en)
DE (2) DE69115229T2 (en)
DK (1) DK0490648T3 (en)
ES (1) ES2079589T3 (en)
FI (1) FI101193B (en)
FR (1) FR2670488B1 (en)
GB (2) GB2280606B (en)
GR (1) GR3018318T3 (en)
HK (2) HK81397A (en)
HU (2) HU213211B (en)
IE (1) IE75348B1 (en)
IL (1) IL100091A (en)
IT (1) IT1256282B (en)
MX (1) MX9102473A (en)
MY (1) MY106315A (en)
NZ (1) NZ240939A (en)
PH (1) PH30928A (en)
RU (1) RU2106140C1 (en)
SK (2) SK279813B6 (en)
TW (1) TW276181B (en)

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US20060287254A1 (en) * 2001-01-26 2006-12-21 Schering Corporation Use of substituted azetidinone compounds for the treatment of sitosterolemia
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EP3168218B1 (en) 2001-08-15 2018-11-14 Pharmacia & Upjohn Company LLC A crystal comprising an l-malic acid salt of n-[2-(diethylamino)ethyl]-5-[(5-fluoro-1,2-dihydro-2-oxo-3h-indol-3-ylidene)methyl]-2,4-dimethyl-1h-pyrrole-3-carboxamide for use as a medicament
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ATE345793T1 (en) * 2001-09-21 2006-12-15 Schering Corp TREATMENT OF XANTHOMA USING AZETIDINONE DERIVATIVES AS STEROL ABSORPTION INHIBITORS
AR040588A1 (en) * 2002-07-26 2005-04-13 Schering Corp PHARMACEUTICAL FORMULATION INCLUDING AN INHIBITOR OF CHOLESTEROL ABSORPTION AND AN INHIBITOR OF A HMGCO TO REDUCTASE
ATE418551T1 (en) * 2003-03-07 2009-01-15 Schering Corp SUBSTITUTED AZETIDINONE DERIVATIVES, THEIR PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF HYPERCHOLESTEROLEMIA
US7459442B2 (en) * 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US7235543B2 (en) * 2003-03-07 2007-06-26 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
US20050026882A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a leukotriene receptor antagonist for treatment of asthma or chronic obstructive pulmonary disease
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Also Published As

Publication number Publication date
ATE131048T1 (en) 1995-12-15
FI915826A0 (en) 1991-12-11
GB9418154D0 (en) 1994-10-26
SK279813B6 (en) 1999-04-13
US5482963A (en) 1996-01-09
ES2079589T3 (en) 1996-01-16
JP2585495B2 (en) 1997-02-26
MY106315A (en) 1995-04-29
CN1105705C (en) 2003-04-16
GB2280606A (en) 1995-02-08
CN1243827A (en) 2000-02-09
IL100091A (en) 1998-08-16
US5504216A (en) 1996-04-02
NZ240939A (en) 1994-05-26
CN1043405C (en) 1999-05-19
KR920011493A (en) 1992-07-24
DK0490648T3 (en) 1996-05-06
BE1004229A5 (en) 1992-10-13
JPH04266824A (en) 1992-09-22
CS375691A3 (en) 1992-06-17
TW276181B (en) 1996-05-21
IE914310A1 (en) 1992-06-17
CA2319308C (en) 2001-08-21
HU213211B (en) 1997-03-28
ITMI913324A0 (en) 1991-12-11
FI915826A (en) 1992-03-31
GR3018318T3 (en) 1996-03-31
EP0490648A1 (en) 1992-06-17
FI101193B1 (en) 1998-05-15
CA2056066C (en) 2002-04-02
KR970005014A (en) 1997-01-29
SK279814B6 (en) 1999-04-13
AP9100340A0 (en) 1992-01-31
AU656157B2 (en) 1995-01-27
KR0183027B1 (en) 1999-05-01
EP0490648B1 (en) 1995-12-06
CN1062291A (en) 1992-07-01
US5993859A (en) 1999-11-30
DE69115229T2 (en) 1996-05-09
US6143775A (en) 2000-11-07
HK81597A (en) 1997-06-27
HK81397A (en) 1997-06-27
IT1256282B (en) 1995-11-29
CA2319308A1 (en) 1992-06-13
HU913865D0 (en) 1992-02-28
FR2670488A1 (en) 1992-06-19
CZ283181B6 (en) 1998-01-14
PH30928A (en) 1997-12-23
FI101193B (en) 1998-05-15
DE4140858A1 (en) 1992-06-17
IL100091A0 (en) 1992-08-18
AP285A (en) 1993-09-23
AU8899491A (en) 1992-06-18
HU211126A9 (en) 1995-10-30
FR2670488B1 (en) 1994-01-28
DE69115229D1 (en) 1996-01-18
IE75348B1 (en) 1997-08-27
KR100207802B1 (en) 1999-07-15
US5319097A (en) 1994-06-07
US5612367A (en) 1997-03-18
GB2251791A (en) 1992-07-22
GB2251791B (en) 1995-05-17
MX9102473A (en) 1992-06-01
RU2106140C1 (en) 1998-03-10
GB2280606B (en) 1995-05-17
GB9126354D0 (en) 1992-02-12
ITMI913324A1 (en) 1993-06-11
HUT61281A (en) 1992-12-28

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