CA2058443A1 - Treating Disorders by Application of Insulin-Like Growth Factors and Analogs - Google Patents

Treating Disorders by Application of Insulin-Like Growth Factors and Analogs

Info

Publication number
CA2058443A1
CA2058443A1 CA2058443A CA2058443A CA2058443A1 CA 2058443 A1 CA2058443 A1 CA 2058443A1 CA 2058443 A CA2058443 A CA 2058443A CA 2058443 A CA2058443 A CA 2058443A CA 2058443 A1 CA2058443 A1 CA 2058443A1
Authority
CA
Canada
Prior art keywords
igf
insulin
analogs
application
growth factors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2058443A
Other languages
French (fr)
Other versions
CA2058443C (en
Inventor
Michael E. Lewis
James C. Kauer
Kevin R. Smith
Kathleen V. Callison
Frank Baldino, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cephalon LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2058443A1 publication Critical patent/CA2058443A1/en
Application granted granted Critical
Publication of CA2058443C publication Critical patent/CA2058443C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/30—Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A method of enhancing the survival of neuronal cells in a mammal, the cells being at risk of dying, the method comprising administering to the mammal an effective amount of at least one of the following substances: IGF-I; a functional derivative of IGF-I; IGF-II; or a functional derivative of IGF-II, provided that if IGF-I or IGF-II is administered, NGF or a functional derivative of NGF is also administered.
CA002058443A 1989-06-05 1990-06-05 Treating disorders by application of insulin-like growth factors and analogs Expired - Lifetime CA2058443C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US361,595 1989-06-05
US07/361,595 US5093317A (en) 1989-06-05 1989-06-05 Treating disorders by application of insulin-like growth factor

Publications (2)

Publication Number Publication Date
CA2058443A1 true CA2058443A1 (en) 1990-12-06
CA2058443C CA2058443C (en) 1998-11-03

Family

ID=23422661

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002058443A Expired - Lifetime CA2058443C (en) 1989-06-05 1990-06-05 Treating disorders by application of insulin-like growth factors and analogs

Country Status (10)

Country Link
US (1) US5093317A (en)
EP (2) EP0798000A3 (en)
JP (1) JPH0768138B2 (en)
AT (1) ATE156018T1 (en)
CA (1) CA2058443C (en)
DE (1) DE69031168T2 (en)
DK (1) DK0476044T3 (en)
ES (1) ES2106735T3 (en)
HK (1) HK1010989A1 (en)
WO (1) WO1990014838A1 (en)

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Also Published As

Publication number Publication date
EP0476044A1 (en) 1992-03-25
EP0476044B1 (en) 1997-07-30
US5093317A (en) 1992-03-03
EP0798000A3 (en) 1998-01-14
DK0476044T3 (en) 1997-11-17
JPH04507240A (en) 1992-12-17
DE69031168D1 (en) 1997-09-04
EP0476044A4 (en) 1992-07-01
CA2058443C (en) 1998-11-03
DE69031168T2 (en) 1997-12-04
EP0798000A2 (en) 1997-10-01
WO1990014838A1 (en) 1990-12-13
ES2106735T3 (en) 1997-11-16
ATE156018T1 (en) 1997-08-15
JPH0768138B2 (en) 1995-07-26
HK1010989A1 (en) 1999-07-02

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