CA2062733A1

CA2062733A1 - Improving blood flow

Info

Publication number: CA2062733A1
Application number: CA002062733A
Authority: CA
Inventors: Nagy Adly Habib
Original assignee: Individual
Current assignee: BTG International Ltd
Priority date: 1989-06-20
Filing date: 1990-06-19
Publication date: 1990-12-21
Also published as: JPH05504693A; DE69033350D1; US5372573A; JP3081639B2; EP0923954A2; WO1990015630A1; AU648984B2; EP0923954A3; EP0478600B1; ES2138582T3; AU5812090A; EP0478600A1; DE69033350T2

Abstract

A provision of improving the flow of blood through a region of increased impedance is disclosed. The provision comprises assisting blood flow is said region by means of a pump placed in or around a blood vessel supplying blood to said area, and acting to pump blood in the required direction. The pump (1) comprises, in one embodiment, a housing (2) annularly surrounding a compressible conduit (3), said housing (2) containing a plurality of flexible inflatable containers (4) mounted for contact with said conduit (3) (e.g. a blood vessel) and means for effecting sequential inflation and deflation of said containers (4) so as to create a peristaltic pumping effect.

Description

WO90/15630 PCT/~B90/00942 2 ~ 6 2 7 r~ ~

~MPROVING BLOOD FLOW

This invention relates to techniques and apparatus for improviny blood flow in vivo. The invention finds application in both clinical ahd veterinary practice.
Numerous problems arise from localised impedance to blood flow in both humans and non-human animals. -For example, arterial damage, e.g. atherosclerosis, in the leg often requires complex surgery in which, typically, the long saphenous vein is used as a graft to by-pass the non-functional arterial region. Also, cirrhosis of the liver, which may result from alcohol -~
abuse in the western world but which is widespread in the third world as a result of viral hepatitis, results in an impedance to blood flow from the hepatic portal vein into the liver. This results in blood by-passing the liver through portal vein tributaries which feed into the stomach. This results in bleeding from the stomach wall (i.e. oesophageal varices).
~ 20 ~he conventional treatment for this condition ; takes several forms: the blood pressure may be relieved by surgically forming a porto-systemic shunt such as a ;
porto-caval shunt, in which the portal vein is connected to the vena cava; or sclerotherapy may be ; 25 used, in which the portal vein tributaries are closed off by an appropriate in~ection. Other conventional treatments are oesophageal transection, in which the portal vein tributaries are closed off by zppropriate sutures; and liver transplantation. These various treatments have various advantages and disadvantages and, in some circumstances, may be of limited value.
Sclerotherapy and oesophageal transection may not be effective over a long per:~d of time because the portal pressure (i.e. the blood pressure in the portal vein) `~ 35 is not reduced and often causes a recurrence of bleeding, and a porto-caval shunt leads to most of the ; ' . .:

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WO90/15630 ~Q ~ 3 PCT/GB90/00942 products absorbed by the gastro-intestinal tract ; passing directly into the general blood circulation, instead of travelling first to the liver where extensive metabolic processes, in particular -detoxification processes, take place. This decrease in blood flow through the liver reduces the effectiveness of this organ, partieularly in its detoxifying - capacity. This in turn can lead to serious side - effects such as hepatic encephalopathy.
It will be appreciated from the above examples that standard treatment for a localised impedance to blood flow is to provide some means whereby blood can by-pass the obstruction, thereby removing the localised hypertension, or to replace the diseased segment as in liver transplantation.
The present invention proceeds from the realisation that this standard approach is flawed. In many clinical or veterinary conditions demonstrating localised blood flow impedance, we believe that superior results may be achieved if instead of providing a surgical by-pass or other conventional treatment, means are adopted whereby blood flow is assisted through the area of impedance. This will generally result in localised hypertension, but the effects of this will not be felt systemically.
Replacing the diseased vessel containing the vascular ;~ imbalance (liver transplantation) is not a practical ; .
propoisition on a large scale because of the high cost o this procedure and because of the limlted availability of donors.
According to one aspect of the present invention, there is provided a method of improving the flow of ~ blood through a region of increased impedance, which I comprises assisting blood flow in the said region by means of a pump placed in or around a blood vessel supplying blood to said area, and acting to pump blood .., . .

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in the re~uired direction.
The pump may be, for example, an Archimedes screw which acts directly on the blood flowing within the vessel undergoing treatment, or it may be a peristaltic-type pump which acts on the outside of the vessel.
The invention will be described further with reference to treatment of the portal vein or hepatic pedicle (free edge of the lesser ormentum) to overcome problems arising from cirrhosis of the liver, although it is to be understood that the invention is of genelal applicability and is not restricted to this specific area of treatment.
The pump for use in this embodiment of the present - 15 invention can be located internally within the portal vein, or it may be of a type (e~g. a peristaltic pump) which permits the motor to act on the exterior of the blood vessel, thereby avoiding the need to perform surgery on the vessel itself. Examples of suitable pumps will now be given.
In one arrangement, the pump is in the form of an Archimedes screw which is located within a suitable prosthesis, e.g. one made of Dacron, which is inserted into or gra~ted between sections of the portal vein.
Control o~ the screw can be achieved by means of a microprocessor housed under the skin close to the site of the portal vein, or located externally in a suitable housing which will generally be held close to the body in the region of the portal vein. A pressure sensor may be incorporated in the screw pump, at the upstream end thereof, and may be incorporated into the control system; for example, the sensor can be used to ensure that the pressure in the portal vein is not greater than 15mm ~g. In order to avoid complications arising ' 35 from thrombosis, the administration of an anticoagulant may be desirable with this arrangement.

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WO90/15630 ~ PCT/GB90/00942 ~Q~ ~ 4-A peristaltic pump acting on the outside of the hepatic portal vein is advantageous in that its use requires less invasive surgery than the embodiment described above. In one arrangement, a conventional roller action is used to generate the peristaltic effect. As with the embodiment described above, control of the pump may be achieved electrically using an externally located microprocessor.
An alternative peristaltic-type pump is also lO advantag~ous; this uses hydraulic or pneumatic power to -generate the required peristaltic action, and as above it can be controlled b~ an externally located ~ microprocessor. ~ne arrangement of this type utilises ; - an annular sheath which conveys a compressive force along its length to assist blood flow within the ; vessel.
One embodiment of the peristaltic type comprises a jacket, sheath or collar which, in use, surrounds the portal vein. In another embodiment, the peristaltic ; 20 pump comprises a plurality of inflatable members which are arranged to overlie the vessel or to sandwich it between them. In both em~odiments, the device is advantageously under control of, for example, a ~ microprocessor. The fluid supply is preferably a :ll 25 pneumatlc supply, and can be provided via an air compressor located outside the body of the patient.
This may be at skin level close to the portal vein. A
l pressure sensor ls preferably located on the surface of ;; the portal veln and is linked to the microprocessor.
When the pressure in that part of the portal vein between the pump and the liver exceeds 15mm Hg, the microprocessor will activate the air compressor and the pneumatic pump action. This will decrease the pressure within the part of the portal vein between the intestine and the pump, which in turn results in cessation of bleeding from the oesophageal varices.

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Also, the pressure in the section of the portal vein between the device and the liver is increased, thus leading to incrsased blood flow into the cirrhotic liver despite the high resistance to blood flow. This in turn should assist in the detoxification of blood before gastro-intestinal products reach the systemic blood supply, thereby leading to an improvement in, or prevention of, hepatic encephalopathy.
According to a second aspect of the present invention, there is provided a pump for assisting flow of liquid in a compressible conduit, wherein said pump comprises a housing annularly surrounding said conduit, said housing containing a plurality of flexible inflatable containers mounted for contact with said ~ 15 vessel and means for effecting sequential inflation and - deflation of said containers so as to create a peristaltic pumping effect.
According to a third aspect of the present invention, there is provided a pump for use in assisting blood flow in a blood vessel which comprises:
;, (1) a housing adapted to fit around the vessel, the ' `
housing being formed in two or more demountable parts l to facilltate emplacement of the housing about said ,'l vessel; (2) at least two in1atable elements disposed ., .
within said housing so that, in use, they contact and ,~ act upon said vessel; (3) means for supplying a fluid ; independently to each of the inflatable elements; and ~, (4) means or controlling supply of fluid to the inflatable elements so as to permit the inflation and de1ation o~ each of them in accordance with a predetermined fluid flow pattern.
Preferably, a device of the type ~ust described is divided into at least two, and typically three annular segments or digitate elements each of which has its own , pneumatic supply, and is under individual control from, , for example, a microprocessor.
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WO90/15630 ~ PCT/GB90/00942 The jacket may be formed of two linked semilunar cusps which can be tied at their edge to form an oblate cylindrical jacket which surrounds the ovoid section of the portal vein. Such a shape is advantageous in that pressure pulses applied via the jacket to the portal vein tend to compress the two "sides" of the ovoid vein evenly. Also, application of the jacket to the portal vein at the free edge of the lesser ormentum is surgically very simple, as opposed to individual dissection of the portal vein. Preferably, the exterior surface of such a jacket is semi-solid, preferabl~ silastic; and the inner surface (which contacts the external wall of the portal vein in use) is membranous so as not to damage the tissue of the portal vein.
Where the jacket comprises three segments or elements, these can be controlled so that each acts as a valve, permitting blood to flow in one direction only. The three segments will be arranged to act -;20 sequentially in a predetermined manner so as to massage the portal vein on order to direct blood unidirectionally towards the liver. A variety of segmental configurations and control arrangements are -possible. For example, all three segments may be ,l25 substantially identical; or the middle segment may be the largest. The control system eithar inflates or ;`deflates the segment (or cuf) to give the required control. It is presently envisaged that a blood flow of up to 1.8 litre per minute from the portal vein into the liver should be possible by means of such a device.
This may be contrasted with situations where, as a result of severe cirrhosis, blood flow through the liver is actually reversed.
A presently preferred arrangement utilises three segments all of which are of the same size. An operating sequence for such a three-segment jacket is WO90/1~630 PCT/GB90/00942 _7_ 2062 7~?-3 as ~ollows, segment 1 being the most distal and segment 3 the most proximal with respect to the liver (i.e.
segment 1 being downstream and segment 3 being upstream with respect to the direction of flow of blood towards ;; 5 the liver):

Time t1 t2 t3 t4 t5 Segment lO 2 D I I D D : .

' ', ,, ~' ' ' where I = inflated, and D = deflated. Other se~uences are possible, provided that unidirectionality of blood ~, 15 flow is maintained. The same sequence may be used with -~
three digitate elements instead of three annular cuffs.
It will thus be seen that compartment 1 (thP
, distal segment) acts as a valve which allows blood to flow only towards the liver. When this segment is ~ 20 inflated, the desired pumping action is achieved by '~! inflating the central segment (segment 2) while the -~, proximal segment 3 is still deflated. This action pumps blood towards the liver. Next, segment 3 is in1ated. Then all three segments are deflated, after 25 which segment 1 i5 in1ated while segments 2 and 3 are deflated, thus priming the pump for the next cycle.
Since a devlce of this type involves minimal surgical intervention, and do~s not involve any dlrect contact with the blood, the use of anticoagulants may not be ~, 30 nesded.
It is envisaged that such a three-compartment ,~ ~acket may be controlled so as to undergo about 60 ~
cycles per minute, although it is preferred that the j;
pressure of operation and the frequency of operation be -under microprocessor control. A device in accordance with this invention may also include one or more pressure sensors associated (in use) with the portal vein. Such sensors may be used to supply information ; to the microprocessor which then controls the operation ', " . .; :
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W09~/15630 ~7 7 ~J3 -8- PCT/GB90/00942 of the device in accordance with prevailing pressure conditions in the portal vein.
A pneumatically operated embodiment such as that described above may have air supply lines for each segment of the jacket which pass through the body of a patient to the exterior, where they are connected to an air compressor. Since the jacket is entirely closed, there is no need to use purified air; the compressor can simply take ambient air and feed this into the segments of the jacket.
A further feature of pneumatic~lly operated Jackets such as just described is that operation of the jacket can be aborted in an emergency simply by cutting the air supply line(s) from the compressor. This represents a considerable safety feature. Also, a sudden decrease in pressure in any one segment (which might be due to perforation of the segment) will lead to stoppage of the pump. Immediate cessation of pump I action in such circumstances will prevent air being introduced into the peritoneal cavity.
In a further embodiment, a section of the portal vein is removed and is replaced by a Jacket which may be in the form described above with reference to an externally applied Jacket. Alternatively, a single compartment annular prosthesis with a single air supply line may be used, but in conJunction with one-way valves at both ends of the Jacket. With this arrangement, inJection of air pumps blood forwards into , the liver, and deflation allows blood to flow into the device from the section of the portal vein between the intestine and the device. Because there is direct contact betwesn the device and the blood, the use of an anticoagulant is preferred with this arrangement.
A devlce in accordance with this invention may be ' 35 used by a patient continuously or intermittently; it may sometimes be advantageous to operate the device for ~ I .
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-9- 2~ ~2 7~3 a period of, say, two, four or eight hours in every twentyfour. In any case, such aspects will be decided in accordance with advice from the patient's surgeon.
Clinical considerations will also be used to determine whether the device is left in situ and used as and when required (both in relation to a diurnal operating regime and in relation to longer term usage, e.g.
operation of the device for four hours in every twentyfour ~or a period of fourteen days, followed by seven days wi~hout use). It may also be feasible to remove the device after a course of treatme~t, an~ to re-apply the device at a later date in the event of regression.
In one embodiment, the device uses a microprocessor and two pressure sensors to control its functioning. One sensor is located so as to sense the prevailing pressure in that segment of the portal vein between the device and the intestines; and the second sensor so as to sense the pressure prevailing in that segment of the portal vein between the device and the liver. For example, if the pressure sensed by the first sensor exceeds 15 mm Hg, the microprocessor will actuate the device; when this pressure falls below 15 mm Hg, the microprocessor will stop the pump action of 25 the device. Similarly, if the pressure sensed by the -second sensor (between the device and the liver) exceeds 100 mm Hg, the microprocessor will respond by switching of~ the pump action of the device, thereby overriding the control command resulting from the , 30 output of the first sensor. This will prevent unacceptably high pressures in the portal vein segment leading to the liver. Functioning of the pump device will then be restored when the pressure sensed by the second sensor falls below 100 mm Hg, provided that the pressure sensed by the first sensor exceeds 15 mm Hg.
It will be appreciated that the pressure given above .

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~$ ~ o-are by way of example only; the device of this invention is preferably arranged so that it can be programmed to respond to any desired limiting pressures in accordance with the surgeon's judgement.
This invention is axpected to find application in other clinical or veterinary conditions involving -increased impedance to blood flow, e.g. cardiac ischaemia and atherosclerosis of the renal artery, as weil as ischaemia of the limbs and brain, and pulmonary hypertension. It may also find use in the relief of ascites.
~^i' The action of the pump on the hepatic portal vein or hepatic pedicle (free edge of the lesser ormentum) in accordance with one aspect of this invention will lS cause a reduction in portal pressure and hence is likely to relieve oesophageal varices. This reduction in portal pressure may also decrease bleeding in the splanchnic territory, which could be an advantage in intestinal surgery.
For a better understanding of the invention and to show how the same may be carried into effect, reference will now be made, by way of example only, to the accompanying drawings, in which:
Figures la to c show a pump in accordance with the invention;
Figures 2a to d show the constrictlon and dilation o the portal vein by a single active unit;
Figure 3 shows a proposed sequence of dilation and constriction of the portal vein;
Figure 4 shows schematically the control and power circuits in one embodiment of the invention;
Figure S shows a diagrammatic representation of apparatus used to define the direction of flow of liquid when pumped by a pump in accordance with the invention;
Figure 6 shows a diagrammatic representation of , ~ .

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2 0 6,~7, 7 ~
apparatus used to define the increase in portal pressure for an increase in ol:tput for a pump in accordance with the invention;
Fig1lre 7 is a graph showing output against portal pressure for the simulated hepatic bed, without action of a pump;
Figures 8a and b show chronographs and sequences of pressurisation and relaxation of the SAS and ECHELON
type cycles;
Figure 9 shows chronographs of the SAS type cycle and three ECHELON type cycles tes~d,o~ tWQ pumps in accordance with one aspect of the invention;
Figure 10 is a diagram showing a comparison of the performances of the SAS, ECHl, 2 and 3 cycles when tested on a pump in accordance with one aspect of the invention;
~ Figure 11 is a graph showing period of cycle ; against output for the two pumps tested;
; Figures 12a and b are diagrams showing comparative performances of the two pumps tested;
Figure 13 is a diagrammatic representation of the apparatus used to test the pumps with simulated collateral branches; and Flgures 14a and b are diagrams showing comparative per~ormances o the two pumps tested with a simulated collateral branah.
Referring ~irst to Figure 1, the pump 1 in accordance with the invention comprises a rigid casing 2 whiah annularly surrounds a vessel 3. The vessel 3 aontains a liquid whiah is to be pumped by the pump 1.
The casing 2 may be constructed of a rigid transparent plastics material, and is divided into two sections (Figure la) so that it may be placed around the vessel 3. These two sections are then ~oined by means of a clip, bolt or other Joining means. Housed inside the casing are two or more, and in this case three, pairs ,'' ' ' ' " '' ' ' ;' . ' ., ' ' ' '~'. .' . ". . : ' . ,':

WO90/15630 ~r~?J ~ ^~ PCT/GB90/00942 of parallel, infla~able ballonets 4. Th~se ballonets 4 are constructed of a flexible plastics material and are connected to a pressure supply (not shown) by means of conduits 5. The pressure supply may be pneumatic or hydraulic, although pneumatic pressure is preferred as ,~ it has a faster response time and the amount of power dissipated in heat is less.
As shown in Figure 2, the pair of ballonets 4 lies ` either side of the vessel 3 so that pressure passing through conduit 5 and into a ballonet causes inflation of the ballonets and hence construction of the vessel 3. Conversely release of pressure from the ballonet causes the vessel to regain its shape. The release of pressure may be passive or by means of a vacuum pump.
The pump has two or more pairs of ballonets 4 so that sequential inflation and deflation of each pair causes constriction of the vessel 3 and hence pumping of the liquid contained therein (Figure 3).
Referring now to Figure 4, the means by which the pump 1 can be regulated and controlled can be seen.
Pressure generated by a compressor 7 is regulated by a pressure reducer 8 before entering the pump 1 via microelectrovalves 9. De1ation of the ballonets 4 is regulated by a vacuum accumulator lO which ensures stabilised constant deflation. The microelectrovalves control the ~low of fluid and are themselves under the - control of a microprocessor 11 and a microcomputer/software 12. The microcomputer 12 is used to deine the cycle o pressurisation and the microprocessor 11 monitors the electrovalves 9 so that an accurate cycle is achieved. Indeed, the period of the cycle may be between 0.251 seconds and 10 seconds l with an accuracy of 1,OOOth of a second.
i Inflation of the ballonets causes a progressive 35 external compression of the vessel 3, and is hence ~ -particularly suited to assisting pumping of fluid in ~ . .
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2~733 vessels such as veins, ducts and arteries. The use of the pump hereinafter will be described with reference to the hepatic portal vein, although it is to be understood that the invention is of general applicability and i5 not restricted to this specific area of use. As mentioned, the pump exerts a progressive external compression on a vessel which avoids injury to the venous wall and total venous occlusion which may be harmful. In use, the ballonets may be oblique to the flow of blood, or may preferably be perpendicular thereto.
The properties of a pump as described above can be characterised on a model of hepatic circulation. The portal vein is represented to scale by a conduit of flexible plastisol with an inner diameter of 20 mm and an outer diameter of 22 mm.
The performance of the pump is dependent on the following parameters:
p - density of li~uid u - dynamic viscosity of liquid g ~ 9.81 ms 2 _ acceleration in the field of gravity ~Qv - change in output ~H - change in charge ; 25 ~P = p.g.~H - change in pressure R a ~P/~Qv ~ hydraulic resistance; in a rigid condult of diameter d and length 1, for a Newtonlan fluid in laminar flow regime ' 30 R= 1 .d-4 , p = p.g~Qv.~H
l or P = ~Qv.~P - useful power transferred by ,, 35 the accelerator to the flow.

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~,r~ 14-In the tests, water is used instead of blood because their densities (p) are very similar (water =
1000 kg/m3, blood = 1060 kg/m3). This similarity means that the transferred energy is substantially the same for both li~uids, but it is assumed that a) that output and hydraulic pressure have the same nominal values as in physiological conditions, and b) that hydraulic and venous rPsistance are the same. Hence the hepatic vascular bed can be simulated to tes~ the pump, although the effect of hepatic arterial circulation, the phenomena of compliance and of opening of areas in the resistive bed, and the behaviour of non-Newtonian blood in the capillaries cannot be simulated.
Figure 5 shows diagrammatically apparatus used to define various characteristics of the pump. In particular the direction of f low of water can be seen by the use of coloured li~uid tracers injected into the apparatus upstream of the pump and the output can be calaulated precisely by the time taken to fill a , 20 standard volume.
The following describes experiments and results obtained in a comparative study of the performance of two pumps each with three pairs of ballonets but varying in their size, the first (A) being larger than the second (B). As mentioned, Figure 5 shows , diagrammatiaally apparatus used, in this case, to determine the dlrection of 1OW of water with and without the action o the pump. In Phase 0, without a pressure gradient between one end of the circuit and the other, the portal output (Qvpo) is nil. With the pump functioning, as shown in Phase 1, water flows towards the area of hepatic resistance (Rhep), despite the resistance to flow being greater in this direction.
;l Figure 6 shows apparatus used to ~ind by how much ` 35 output is increased by action of the pump. Figure 7 shows how an increase in hepatic portal pressure Hp ... . .
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~WO90/15630 PCT/GB90/00942 -15- ~a2733 affects an increase in output Qv without the pump being used. HpaVl is the portal pressure which has to be generated for reestablishing output Qvpl with the pump at rest.
Referring now to Figures 8a and b, the - effectiveness of the SAS and ECHELON type cycles can be -; assessed. As can be seen, the SAS cycle guarantees a one-way flow of li~uid and prevents any backflow but has the disadvantage that it involves total venous occlusion, and hence the risk of venous wall damage.
It also involves many sequences and can only transfer a low volume of liquid. The ECHELON type cycle cannot guarantee a prevention of backflow but propagates wave amplification without as many sequences of inflation `
and deflation or the need for venous occlusion.
Chronographs of the various cycles tested are shown in Figure 9, and Figure lO shows a comparison of the performances of each of these cycles. As can be seen, the cycle ECH3 is more effective whatever the Hpo and Rhep values. This cycle has therefore been retained for a further study of the characteristics of the pump;
` The optimum period of cycle Tm~ i.e. the length of time for a complete cycle as shown in Figure 8b, can be ound by varying the period o~ cycle T and examining ii25 the output Qvp- Figure 11 shows how the optimum period 'ITm can be found for both pumps 1 and 2 by plotting period of cyale T against output vp' '!~ When Tm is defined, the optimum speed o compression can be found by using the formula l 30 ;~ Tm `,where d is the distance between the central axes of the ballonets. For both pumps, Cm is virtually identical:
` 35 Cm1 =22 = 44 mms~2 0.5 ' i . : ' ' `. . .
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Cm2 = 13 = 43.3 mms~2 ~ ' 0.3 Figures 12a and b summarise the data contained in Table l below, for the two pumps tested on the simulation of hepatic circulation described.

Table 1 .phase 0 phasc I
_ , H 0 Qvpo P~ Qvp !Qv p ~Qvp Hp AY I I~H ?
15mm Hgl~min n- I/min I/min 7. mm Hg mm Hg mW
.~ ~ O 0, 651 1, 120, 4~ 7Z 20,41 0,4 .~ _ 2 1, 32 0 . 675 104~S, S I S, S 23 ,3 .~ 22 0 50 1 0, 840, 34 68 46, ~ Z4 ,4 1 8 ';'~ . 2 0,80 0,30 60 l 19 13 i', 20 .,1 ! It can be seen that the increase in portal output ~Qvp and maximum of transferred power P is obtained with low hypertension. ~H, the excess pressure applied increases with the hypertension.
Pump No. 2 is most efficient with moderate hypertension, although pump No. 1 is more efficient at 30 higher hypertension.
The per~ormances of the two pumps may also be measured using a simulation of the collateral branch (simulating collateral circulation between the systemic and portal circulations). The apparatus used for this 1 35 may be seen in Figure 13, where a branch with 'l collateral resistance Rc is placed upstream of the . . ~ , .
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SUBSTITUTE SHEET
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WO90tl5630 PCT/GB90/00942 -17- 2Z~Z~73~
pump. The results for pumps 1 and 2 can be seen both in Table 2 below and Figures 14a and 14b. Action of the two pumps leads to increased portal output (~Qvp)~
decreased portal pressure (~H) and decreased flow in the collateral (~Qvc) ~ ,.': : :
Table 2 '' .'- '~:
, 10 ~h~se 0 phase 1 .... ~ _ _ r ~ ~ p O ~ P c~ V C O H Q v s (? V p l Q ~ c l ~ H ~ ~ v ~ ~ v ~
". mlll Hg I,'min¦ n' ¦ I/min l~min mm Hg l~mln I/min I/min mm Hg I/min l~min¦
__ o 5 1 1o.~o o ~o 6,S 0,76 0.2~ -8,5 ~0~I6 -o 16i 1 5 . ~, I j . _ :: ~ 10.64 1 36 5,9 l 0.~.1 0.19 -9.1 1 0 17 -0 17 . . . .
~, 22 O.S0 1 IO.~S 10,s2 9.2 l 0,71 0,29 -12,81~0,23 2 1 o, ~J 1 ~ 5 ! 9, 9 , 0, 69 0, 31 - I 2 . I l ~0, 20 0, 20 ,'~ .

;' For both pumps the gain on portal output and decrease in portal pressure are accentuated with l, hypertension. Pump 2 is again more efficient at 'Z 25 moderate hypertension and pump 1 ls more efficient with high hypertension. ~owever the dif~erence between the efficiencies is minimal and the performance of the two '~ pumps in these tests is very similar.
The invention may be further illustrated by means ' 30 of the following examples: -I Our new hypothesis is that it is possible to ; reduce the portal pressure in the oesophageal varices by increasing the portal blood flow across the Z cirrhotic liver. This would have the double advantage 35 of preventing rebleeding without reducing the liver portal flow. To test this hypothesis we devised two ' SUBSTITIJTZE~ SHEET ~ ~ ~

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WO90/15630 ~ PCT/GB90/00942 experiments. The first (Example 1) was to investigate - the relationship between portal pressure and liver portal flow in cirrhotic rat liver using the isolated liver perfusion model (Miller, L.L., Technique of liver perfusion. In: Bartosek, I., Guitani, A., Miller, L.L.
eds. Isolated liver perfusion and its applications.
New York: Raven Press, 1973: 11-52). The second (Example la) was to assess the ability of a newly ` designed pump to improve liver portal flow and reduce splanchnic portal pressure in pigs.
ExaMpLE 1 Liver cirrhosis was induced in Sprague-Dawley rats by IP injection of 0.3 ml carbon tetrachloride in mineral oil, three times weekly for 8 weeks. Two weeks following the last injection, the rats were submitted to laparotomy and the portal pressure was recorded by direct puncture of the portal vein. The livers were removed and placed in a modified isolated perfused system where the perfusion pressure varied from 0 to : 20 45cm H2O. The perfusion solution was the oxygenated (2 95~ and CO2 5~), heated (37C) Krebs-albumin solution (pH 7.40 + 0.05). The base-line portal flow was measured for 2C minutes during which the portal pressure applied was equal to that measured in vivo prior to the sacrifice of the animal. The portal flow was then measured in the normal and cirrhotic livers '~ over a period o~ 35 minutes. The portal flow was measured for 15 minutes at a higher pressure of either 25 or 45 cm of H2O. Cirrhosis was confirmed histologically. Statistical analyses were made with ;, the unpaired Student's t-test.
In the normal control rats (n = 15), the base line " portal pressure was 10.3 + 0.67 cm of H2O. Subsequent increase of portal pressure to 25 cm of H2O in 10 of 35 these rats increased the portal flow from 3.38 + 0.86 ml/min.gm~1 to 6.25 + 1.2 ml/min.gm~1 (P<0.001) while ,. . .
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-19- 2~2~3 increase of portal pressure to 45 cm of H20 in the other 5 rats increased the portal flow from 2.23 + 0.42 -ml/min.gm~1 to 10.42 + 1.42 ml/min.gm~l (P<0.001).
In the cirrhotic rats (n = 14), the base line S portal pressure was 13.1 + 2.~1 cm of H20. It was significantly (P<0.001) increased compared to the ; baseline portal pressure in normal rats. Increase of portal pressure to 25 cm H20 in six of these rats increased the portal flow from 2.32 + 0.75 to 3.97 +
1.29 ml/min.gm~l (P>O.OS) while increasing the portal pressure to 45 cm of H20 in the other four rats caused a rise in portal flow from 1.64 + 0.32 to 4.50 + 1.18 ml/min.gm 1 (P<0.001). Histological examination of the normal and cirrhotic livers showed no parenchymal damage following increased portal pressure.
In the normal liver the doubling of portal pressure was associated with a doubling of portal flow (105% and 360% increase in portal pressure was associated with a 91% and 383% increase ~n portal flow '~ 20 respectively). In the cirrhotic liver, there was a similar direct relationship (i.e. 88% and 215% increase in portal pressure was associated with a 72% and 178%
', increase in portal flow respectively).
Therefore in both normal and cirrhotic liver, increase portal pressure was assoPiated with a significant increase in portal flow.
. .
I XAMPLE la i' , ' ':
i, 30 Two 70kg pigs were anaesthetized and submitted to laparotomy. Via a bilateral subcostal incision the i' portal vein was~dissected. The portal pressure was ;~¦ recorded with the insertion of a cannula in a ~ejunal `' vein. Another catheter was introduced via another Je~unal vein and advanced beyond the portal vein , bifurcation. The portal flow was measured continuously , "
' ' ~'~"
.,~ .
. .~i ' WO90/15630 PCTtGB90/00942 ~q~ -20-with Gould-Stratham 2202 flow meter using a probe placed around the main left branch of the portal vein.
Following this, the branches of the portal vein were dissected. All the right and one left segmental portal branches were ligated. This raised the portal pressure in the first pig from 13 to 24 mm Hg and in the second pig from 12 to 23 mm Hg. It also reduced the liver portal flow from 950 to 700 ml/min in the first pig and from 650 to 180 ml/min in the second pig.
At this stage, a pump in accordance with one aspect of the present invention was applied around the portal vein. The pump consisted of an air driven pump composed of three pairs of balloons enveloped by a rigid box. The three pairs worked in a cyclical sequence controlled by computer. The length, width and height of the balloon were 35mm, llmm and lOmm, respectively. The cycle duration was 0.8 second. The pressure in the balloons was generated with a ; compression-vacuum generator with an applied pressure of 0.32 bar.
Measurements of portal pressures and liver portal '~ flow were repeated in both pigs with successive ;
applications o the pump. Statistical analysis were , made with paired t-test.
Five successive activations of the pump in the first pig r~duced the splanchnic portal pressure from 23.7 + 1.09 mm to 19.7 ~ 0.67 mm Hg (downstream of the ~` pump) (P~0.01) and increased the portal pressure upstream o the pump rom 23.88 _ 0.54 mm to 31.24 +
2.54 mm Hg. This was associated with an increase in portal flow from 693 + 11 to 842 + 13 ml/min (P<0.001).
` In the second pig, activation of the pump reduced the ~;
`'~ splanchnic portal pressure (downstream of the pump) from 21.75 + 1.5 to 18.5 + 1.29 mm Hg and increased the portal pressure upstream to the pump from 21.5 ~ 1.91 to 24.5 + 2.51 mm Hg (P~0.05). This was associated "' '' . .
. ` .

2~2~33 with an increase in portal flow from 215 + 73 to 280 +
70 ml/min (P<O.OO1).
Our in vitro study shows that increased portal pressure leads to increased portal flow. This was observed in both normal and cirrhotic liver using the - isolated perfused model. Conventional histological examination of these livers did not reveal any parenchymal damage following brief periods of increased portal pressures.
In the reported in vivo experiments in pigs (Example la) with portal hypertension, the pump reduced the splanchnic portal pressure and simultaneously increased the portal liver flow.
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Claims

CLAIMS:

1. A method of improving the flow of blood through a region of increased impedance, which comprises assisting blood flow in said region by means of a pump placed in or around a blood vessel supplying blood to said area, and acting to pump blood in the required direction.

2. A method as claimed in claim 1, wherein said pump is an Archimedes screw.

3. A method as claimed in claim 1, wherein said pump is a peristaltic-type pump.

4. A method as claimed in claim 2, wherein said Archimedes screw is located within a prosthesis which is inserted into or grafted between sections of said blood vessel.

5. A method as claimed in claim 3, wherein said peristaltic-type pump generates its peristaltic effect by a roller action.

6. A method as claimed in claim 3, wherein said peristaltic-type pump uses hydraulic or pneumatic power to generate its peristaltic effect.

7. A method as claimed in claim 6, wherein said peristaltic type pump uses pneumatic power provided via an air compressor located outside the body of the patient.

8. A method as claimed in claim 6 or 7, wherein said peristaltic-type pump comprises a jacket, sheath or collar which surrounds said blood vessel.

9. A method as claimed in claim 8, wherein said jacket, sheath or collar is divided into three annular compartments, and wherein each of said compartments is supplied independently with its own pneumatic or hydraulic supply.

10. A method as claimed in claim 9, wherein said segments are inflated and deflated sequentially as shown by the following table, compartment 1 being the most distal and compartment 3 being the most proximal with respect to said area of impedance and D indicating deflation and I indicating inflation:

11. A method as claimed in claim 1, wherein a section of said blood vessel is removed and replaced by a jacket, sheath or collar, and blood is caused to flow by the combination of inflation of said jacket and one-way valves at both ends of the jacket.

12. A method as claimed in any preceding claim, wherein operation of said pump is controlled by a microprocessor.

13. A method as claimed in claim 12, wherein said microprocessor is located at skin level close to the site of the blood vessel.

14. A method as claimed in claim 12, wherein said microprocessor is located externally in a housing.

15. A method as claimed in any preceding claim, wherein the pressure in said blood vessel either side of said pump is monitored by means of first and second sensors, said first sensor being located so as to sense the prevailing pressure in that segment of said blood vessel upstream of said pump and said second sensor being located so as to sense the prevailing pressure in that segment of said blood vessel downstream of said pump.

16. A method as claimed in claims 12 and 15, wherein said first and second sensors are connected to said microprocessor so as to control the action of said pump within preset pressure limits.

17. A method as claimed in any preceding claim wherein said blood vessel is the hepatic portal vein.

18. A method as claimed in any preceding claim, which method is used for the treatment of cirrhosis of the liver, ascites, encephalopathy, bleeding of oesophageal varices, liver insufficiency, cardiac ischaemia, atherosclerosis of the renal artery, ischaemia of the limbs or brain, or pulmonary hypertension.

19. A pump for assisting flow of liquid in a compressible conduit, wherein said pump comprises a housing annularly surrounding said conduit, said housing containing a plurality of flexible inflatable containers mounted for contact with said conduit and means for effecting sequential inflation and deflation of said containers so as to create a peristaltic pumping effect.

20. A pump as claimed in claim 19, wherein said housing is divided parallel to the direction of flow of said liquid so that it may be placed around said vessel.

21. A pump as claimed in claim 19 or 20, wherein said means for sequential inflation and deflation comprises a pressure source, a pressure regulator, a microprocessor and a microcomputer.

22. A pump as claimed in claim 21, wherein said means for sequential inflation and deflation further comprises microelectrovalves.

23. A pump for use in assisting blood flow in a blood vessel which comprises:
(1) a housing adapted to fit around the vessel, the housing being formed in two or more demountable parts to facilitate emplacement of the housing about said vessel;
(2) at least two inflatable elements disposed within said housing so that, in use, they contact and act upon said vessel;
(3) means for supplying a fluid independently to each of the inflatable elements, and (4) means for controlling supply of fluid to the inflatable elements so as to permit the inflation and deflation of each of them in accordance with a predetermined fluid flow pattern.

24. A pump as claimed in claim 23, wherein said means for supplying a fluid and means for controlling supply of fluid comprise a pressure source, a pressure regulator, a microprocessor and a microcomputer.

25. A pump as claimed in claim 24, wherein said means for controlling supply of fluid further comprises microelectrovalves.

26. A pump as claimed in any one of claims 19 to 25, wherein said housing is formed of a substantially rigid plastics material.

27. A pump as claimed in any one of claims 19 to 26, wherein said containers are formed of a substantially extendible plastics material.

28. A pump as claimed in any of claims 19 to 27, wherein said pump further comprises one or more pressure sensors.

29. A pump as claimed in any one of claims 19 to 28, wherein said containers or elements lie parallel to one another and perpendicular to the direction of flow of said liquid.

30. A pump as claimed in any one of claims 19 to 29, wherein said containers or elements are inflated and deflated sequentially as shown in the following Table, container or element 1 being downstream and container or element 3 being upstream with respect to the direction of flow, and I indicating inflation and D
indicating deflation: