CA2065003A1 - Enhanced nucleic acid amplification process - Google Patents

Enhanced nucleic acid amplification process

Info

Publication number
CA2065003A1
CA2065003A1 CA2065003A CA2065003A CA2065003A1 CA 2065003 A1 CA2065003 A1 CA 2065003A1 CA 2065003 A CA2065003 A CA 2065003A CA 2065003 A CA2065003 A CA 2065003A CA 2065003 A1 CA2065003 A1 CA 2065003A1
Authority
CA
Canada
Prior art keywords
nucleic acid
primer
sequence
specific nucleic
template
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2065003A
Other languages
French (fr)
Other versions
CA2065003C (en
Inventor
Lawrence T. Malek
Cheryl Davey
Graham Henderson
Roy Sooknanan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cangene Corp
Original Assignee
Lawrence T. Malek
Cheryl Davey
Graham Henderson
Roy Sooknanan
Cangene Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lawrence T. Malek, Cheryl Davey, Graham Henderson, Roy Sooknanan, Cangene Corporation filed Critical Lawrence T. Malek
Publication of CA2065003A1 publication Critical patent/CA2065003A1/en
Application granted granted Critical
Publication of CA2065003C publication Critical patent/CA2065003C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6865—Promoter-based amplification, e.g. nucleic acid sequence amplification [NASBA], self-sustained sequence replication [3SR] or transcription-based amplification system [TAS]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Abstract

This invention relates to an improved process for amplifying a specific nucleic acid sequence. The process involves synthesizing single-stranded RNA, single-stranded DNA and double-stranded DNA. The single-stranded RNA
is a first template for a first primer, the single-stranded DNA
is a second template for a second primer, and the double stranded DNA is a third template for synthesis of a plurality of copies of the first template. A sequence of the first primer or the second primer is complementary to a sequence of the specific nucleic acid and a sequence of the first primer or the second primer is homologous to a sequence of the specific nucleic acid. The amplification process may be used to increase the quantity of a specific nucleic acid sequence to allow detection, or to increase the purity of a specific nucleic acid sequence as a substitute for conventional cloning methodology.
CA002065003A 1989-08-23 1990-08-23 Enhanced nucleic acid amplification process Expired - Lifetime CA2065003C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/397,681 US5130238A (en) 1988-06-24 1989-08-23 Enhanced nucleic acid amplification process
US397,681 1989-08-23

Publications (2)

Publication Number Publication Date
CA2065003A1 true CA2065003A1 (en) 1991-02-24
CA2065003C CA2065003C (en) 1998-09-01

Family

ID=23572204

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002065003A Expired - Lifetime CA2065003C (en) 1989-08-23 1990-08-23 Enhanced nucleic acid amplification process

Country Status (13)

Country Link
US (1) US5130238A (en)
EP (1) EP0487628B1 (en)
JP (1) JP2648802B2 (en)
KR (1) KR960005737B1 (en)
AT (1) ATE154644T1 (en)
AU (1) AU647411B2 (en)
CA (1) CA2065003C (en)
DE (1) DE69030955T2 (en)
DK (1) DK0487628T3 (en)
ES (1) ES2104611T3 (en)
FI (1) FI100192B (en)
NZ (1) NZ235009A (en)
WO (1) WO1991002818A1 (en)

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