CA2065390A1 - Artificial pancreatic perfusion device - Google Patents

Artificial pancreatic perfusion device

Info

Publication number
CA2065390A1
CA2065390A1 CA2065390A CA2065390A CA2065390A1 CA 2065390 A1 CA2065390 A1 CA 2065390A1 CA 2065390 A CA2065390 A CA 2065390A CA 2065390 A CA2065390 A CA 2065390A CA 2065390 A1 CA2065390 A1 CA 2065390A1
Authority
CA
Canada
Prior art keywords
islets
hollow fiber
suspended
enclosed
semi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2065390A
Other languages
French (fr)
Other versions
CA2065390C (en
Inventor
William L. Chick
Susan J. Sullivan
Kermit M. Borland
John M. Harvey
Thomas E. Muller
Karen E. Dunleavy
Edward J. Doherty
Barry A. Solomon
Amy L. Foley
Donald P. King, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WR Grace and Co Conn
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2065390A1 publication Critical patent/CA2065390A1/en
Application granted granted Critical
Publication of CA2065390C publication Critical patent/CA2065390C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3475—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate with filtrate treatment agent in the same enclosure as the membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1678—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes intracorporal

Abstract

A device which serves as an artificial pancreas comprises a hollow fiber (12) having an inner diame-ter of about 5 mm which is surrounded by islets of Langerhans (14) enclosed in a housing (42). The islets (14) are suspended in a semi-solid matrix which en-sures desired distribution of the cells about the hol-low fiber (12). The hollow fiber (12) and suspended islets (14) are enclosed in a housing (20, 22) which further aids the desired distribution of islets (14) about the hollow fiber (12). The hollow fiber (12) has a porosity which selectively allows passage of sub-stances having a molecular weight of less than about 100,000 Daltons. The semi-solid matrix in which the islets (14) are embedded and suspended is formed of an appropriate supporting material such as alginate or agar.
CA002065390A 1989-08-25 1990-02-22 Artificial pancreatic perfusion device Expired - Fee Related CA2065390C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US398,739 1989-08-25
US07/398,739 US5002661A (en) 1989-08-25 1989-08-25 Artificial pancreatic perfusion device

Publications (2)

Publication Number Publication Date
CA2065390A1 true CA2065390A1 (en) 1991-02-26
CA2065390C CA2065390C (en) 1996-09-24

Family

ID=23576610

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002065390A Expired - Fee Related CA2065390C (en) 1989-08-25 1990-02-22 Artificial pancreatic perfusion device

Country Status (10)

Country Link
US (1) US5002661A (en)
EP (1) EP0489014B1 (en)
JP (1) JPH04507051A (en)
AT (1) ATE113817T1 (en)
AU (1) AU641164B2 (en)
CA (1) CA2065390C (en)
DE (1) DE69014125T2 (en)
DK (2) DK0489014T3 (en)
ES (1) ES2063356T3 (en)
WO (1) WO1991002498A1 (en)

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IT1231916B (en) * 1989-05-29 1992-01-15 Ampliscientifica S R L WEARABLE ARTIFICIAL PANCREAS
US5116493A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5116494A (en) * 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with temperature sensitive matrix
US5744327A (en) * 1990-02-20 1998-04-28 Board Of Regents, The University Of Texas System Methods for producing insulin in response to non-glucose secretagogues
US5427940A (en) * 1991-06-03 1995-06-27 Board Of Regents, The University Of Texas System Engineered cells producing insulin in response to glucose
US5733336A (en) * 1990-10-31 1998-03-31 Baxter International, Inc. Ported tissue implant systems and methods of using same
US5344454A (en) * 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
DK0507933T3 (en) * 1990-10-31 1996-06-17 Baxter Int Near-vascularizing implant material
US5713888A (en) * 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5314471A (en) * 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
DE4108772A1 (en) * 1991-03-18 1992-09-24 Inst Textil & Faserforschung IMPLANTABLE BIOHYBRID ORGAN
US5800829A (en) * 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
ES2107537T3 (en) * 1991-04-25 1997-12-01 Univ Brown Res Found IMMUNO INSULATED BIOCOMPATIBLE VEHICLE IMPLANTABLE TO SUPPLY SELECTED THERAPEUTIC PRODUCTS.
US5792656A (en) * 1991-06-03 1998-08-11 Board Of Regents, The University Of Texas System Methods of preparing genetically engineered cells that produce insulin in response to glucose
US5453278A (en) * 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
US6773458B1 (en) 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US5370681A (en) * 1991-09-16 1994-12-06 Atrium Medical Corporation Polyumenal implantable organ
EP1099423A3 (en) * 1991-09-16 2001-11-14 Atrium Medical Corporation Controlled porosity implantable primary lumen device
US5298206A (en) * 1992-02-04 1994-03-29 W. R. Grace & Co.-Conn. Method and apparatus for casting hollow fiber membranes
US5387237A (en) * 1992-07-30 1995-02-07 The University Of Toledo Bioartificial pancreas
US5425764A (en) * 1992-07-30 1995-06-20 The University Of Toledo Bioartificial pancreas
GB9311784D0 (en) * 1993-06-08 1993-07-28 Univ Alberta Vascular bioartificial organ
AU678843B2 (en) 1993-08-10 1997-06-12 W.L. Gore & Associates, Inc. Cell encapsulating device
ATE218893T1 (en) * 1993-08-12 2002-06-15 Neurotech Sa BIOCOMPATIBLE IMMUNOISOLATION CAPSULES CONTAINING GENETICALLY MODIFIED CELLS
US5908623A (en) * 1993-08-12 1999-06-01 Cytotherapeutics, Inc. Compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
CA2148354A1 (en) * 1993-09-24 1995-03-30 Laura A. Martinson Methods for enhancing vascularization of implant devices
US5550050A (en) * 1994-04-15 1996-08-27 Cytotherapeutics, Inc. Method for implanting encapsulated cells in a host
US6156305A (en) * 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
US5858747A (en) * 1994-07-20 1999-01-12 Cytotherapeutics, Inc. Control of cell growth in a bioartificial organ with extracellular matrix coated microcarriers
US5935849A (en) * 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US6495364B2 (en) * 1995-05-23 2002-12-17 Neurotech, S.A. Mx-1 conditionally immortalized cells
US5681740A (en) * 1995-06-05 1997-10-28 Cytotherapeutics, Inc. Apparatus and method for storage and transporation of bioartificial organs
US5741334A (en) * 1995-06-07 1998-04-21 Circe Biomedical, Inc. Artificial pancreatic perfusion device
WO1997010807A1 (en) * 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
US5854067A (en) * 1996-01-19 1998-12-29 Board Of Regents, The University Of Texas System Hexokinase inhibitors
US6087129A (en) 1996-01-19 2000-07-11 Betagene, Inc. Recombinant expression of proteins from secretory cell lines
CA2218623A1 (en) * 1996-02-23 1997-08-28 Circe Biomedical, Inc. Novel artificial pancreas
US5976780A (en) * 1996-07-16 1999-11-02 Shah; Kumarpal A. Encapsulated cell device
ZA9710342B (en) * 1996-11-25 1998-06-10 Alza Corp Directional drug delivery stent and method of use.
US5985151A (en) * 1997-12-19 1999-11-16 Saman Ahmadi Method and apparatus of membrane separation
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US8252044B1 (en) 2000-11-17 2012-08-28 Advanced Bio Prosthestic Surfaces, Ltd. Device for in vivo delivery of bioactive agents and method of manufacture thereof
US10398830B2 (en) * 2000-11-17 2019-09-03 Vactronix Scientific, Llc Device for in vivo delivery of bioactive agents and method of manufacture thereof
US9107605B2 (en) * 2000-11-17 2015-08-18 Advanced Bio Prosthetic Surfaces, Ltd., A Wholly Owned Subsidiary Of Palmaz Scientific, Inc. Device for in vivo delivery of bioactive agents and method of manufacture thereof
EP1581640A2 (en) * 2002-12-24 2005-10-05 An-Go-Gen Inc. Encapsulated cells for therapy
WO2007078922A2 (en) * 2005-12-30 2007-07-12 Neurotech Usa Inc. Micronized device for the delivery of biologically active molecules and methods of use thereof
WO2010032242A1 (en) * 2008-09-17 2010-03-25 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
US9446168B2 (en) 2010-06-07 2016-09-20 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
EP2356227B1 (en) 2008-11-14 2018-03-28 Viacyte, Inc. Encapsulation of pancreatic cells derived from human pluripotent stem cells
US20100272780A1 (en) * 2009-04-23 2010-10-28 Vincent Ling CELL LINES THAT PRODUCE PROSTAGLANDIN F2 ALPHA (PGF2a) AND USES THEREOF
WO2012075184A2 (en) 2010-12-02 2012-06-07 Neurotech Usa, Inc. Cell lines that secrete anti-angiogenic antibody-scaffolds and soluble receptors and uses thereof
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
EP3398559B1 (en) 2013-03-07 2024-05-01 ViaCyte, Inc. 3-dimensional large capacity cell encapsulation device assembly
AU2016267579B2 (en) 2015-05-27 2024-02-01 Neurotech Usa, Inc. Use of encapsulated cell therapy for treatment of ophthalmic disorders
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EP3398558A1 (en) * 2017-05-02 2018-11-07 Carlo Andretta In body perfusion system
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US20210093435A1 (en) * 2019-09-27 2021-04-01 Isla Technologies, Inc. Bioartificial pancreas
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Also Published As

Publication number Publication date
AU5733390A (en) 1991-04-03
DE69014125D1 (en) 1994-12-15
JPH04507051A (en) 1992-12-10
EP0489014A1 (en) 1992-06-10
AU641164B2 (en) 1993-09-16
WO1991002498A1 (en) 1991-03-07
DE69014125T2 (en) 1995-03-23
ES2063356T3 (en) 1995-01-01
CA2065390C (en) 1996-09-24
DK23192A (en) 1992-02-24
ATE113817T1 (en) 1994-11-15
DK23192D0 (en) 1992-02-24
DK0489014T3 (en) 1995-05-01
US5002661A (en) 1991-03-26
EP0489014B1 (en) 1994-11-09

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