CA2066423A1 - Compositions and methods of manufacture of oral dissolvable medicaments - Google Patents

Compositions and methods of manufacture of oral dissolvable medicaments

Info

Publication number
CA2066423A1
CA2066423A1 CA 2066423 CA2066423A CA2066423A1 CA 2066423 A1 CA2066423 A1 CA 2066423A1 CA 2066423 CA2066423 CA 2066423 CA 2066423 A CA2066423 A CA 2066423A CA 2066423 A1 CA2066423 A1 CA 2066423A1
Authority
CA
Canada
Prior art keywords
manufacture
compositions
methods
oral dissolvable
medicaments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2066423
Other languages
French (fr)
Other versions
CA2066423C (en
Inventor
Theodore H. Stanley
Brian Hague
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Utah Research Foundation UURF
Original Assignee
Theodore H. Stanley
Brian Hague
University Of Utah (The)
University Of Utah Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theodore H. Stanley, Brian Hague, University Of Utah (The), University Of Utah Research Foundation filed Critical Theodore H. Stanley
Publication of CA2066423A1 publication Critical patent/CA2066423A1/en
Application granted granted Critical
Publication of CA2066423C publication Critical patent/CA2066423C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/364—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
    • A23G3/368—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
    • A23G3/54—Composite products, e.g. layered, coated, filled
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
    • A23G3/56—Products with edible or inedible supports, e.g. lollipops
    • A23G3/563—Products with edible or inedible supports, e.g. lollipops products with an inedible support, e.g. a stick
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/003—Sticks, e.g. lollipops with drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Abstract

Dosage form and method of manufacture for producing a medicament capable of absorption through mucosal tissues. The drug (24) is to be incorporated into a dissolvable matrix (22). An appliance or holder (26) is attached to the dissolvable matrix (22) and mounted or sealed against button (28). <IMAGE>
CA002066423A 1989-09-05 1990-08-03 Compositions and methods of manufacture of oral dissolvable medicaments Expired - Lifetime CA2066423C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US403,751 1989-09-05
US07/403,751 US5288497A (en) 1985-05-01 1989-09-05 Compositions of oral dissolvable medicaments

Publications (2)

Publication Number Publication Date
CA2066423A1 true CA2066423A1 (en) 1991-03-06
CA2066423C CA2066423C (en) 1998-04-14

Family

ID=23596872

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002066423A Expired - Lifetime CA2066423C (en) 1989-09-05 1990-08-03 Compositions and methods of manufacture of oral dissolvable medicaments

Country Status (11)

Country Link
US (1) US5288497A (en)
EP (2) EP0630647B1 (en)
JP (1) JP2717024B2 (en)
AT (2) ATE177007T1 (en)
AU (2) AU645265B2 (en)
CA (1) CA2066423C (en)
DE (2) DE69032982T2 (en)
DK (2) DK0490916T3 (en)
ES (2) ES2133448T3 (en)
NO (1) NO304348B1 (en)
WO (1) WO1991003237A1 (en)

Families Citing this family (181)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US5824334A (en) * 1989-09-05 1998-10-20 University Of Utah Research Foundation Tobacco substitute
IT1238072B (en) * 1990-01-19 1993-07-03 Sclavo Spa PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ORAL ADMINISTRATION OF CALCITONIN
US5223259A (en) * 1990-09-19 1993-06-29 Lackney Albert M Securing means for an oral medicament and support therefor
WO1993010758A1 (en) * 1991-12-05 1993-06-10 Pitman-Moore, Inc. A carbohydrate glass matrix for the sustained release of a therapeutic agent
WO1993012769A1 (en) * 1991-12-24 1993-07-08 Yamanouchi Pharmaceutical Co., Ltd. Intrabuccally disintegrating preparation and production thereof
GB9212511D0 (en) * 1992-06-12 1992-07-22 Cortecs Ltd Pharmaceutical compositions
GB9213874D0 (en) * 1992-06-30 1992-08-12 Fisons Plc Process to novel medicament form
JPH0776527A (en) * 1993-06-28 1995-03-20 Hayashibara Biochem Lab Inc Semi-solid preparation and production thereof
US5549906A (en) * 1993-07-26 1996-08-27 Pharmacia Ab Nicotine lozenge and therapeutic method for smoking cessation
WO1995003771A1 (en) * 1993-08-03 1995-02-09 Pacific Rim Productions Pty. Ltd. Treatment of oral ailments
US6352713B1 (en) 1999-12-01 2002-03-05 Drugtech Corporation Nutritional composition
US6488956B1 (en) * 1994-06-20 2002-12-03 Drugtech Corporation Multi-vitamin and mineral supplements for women
MA23587A1 (en) * 1994-06-23 1995-12-31 Procter & Gamble TREATMENT OF NEED FOR NICOTINE AND / OR SMOKING-RELATED SYNDROME
WO1996000069A1 (en) * 1994-06-23 1996-01-04 The Procter & Gamble Company Treatment of nicotine craving and/or smoking withdrawal symptoms with a solid or semi-solid composition containing nicotine and caffeine or xanthine, especially for nasal administration
WO1996000072A1 (en) * 1994-06-23 1996-01-04 The Procter & Gamble Company Treatment of nicotine craving and/or smoking withdrawal symptoms with a transdermal or transmucosal composition containing nicotine and caffeine or xanthine
GB2325408B (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Chewing gum formulation comprising ondansetron
GB9423511D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
CN1172433A (en) * 1995-02-02 1998-02-04 中外制药株式会社 Sucralfate preparation
US5788982A (en) * 1995-06-16 1998-08-04 Nadoolman; Wolffe Method and composition for treating oral pain using capsaicin
GB9517062D0 (en) * 1995-08-18 1995-10-25 Scherer Ltd R P Pharmaceutical compositions
US5912014A (en) * 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
SE9601421D0 (en) * 1996-04-12 1996-04-12 Astra Ab New composition
DK0906089T3 (en) 1996-05-13 2003-12-08 Novartis Consumer Health Sa The buccal delivery system
US5726154A (en) * 1996-06-28 1998-03-10 University Of Utah Research Foundation Stabilization and oral delivery of calcitonin
CA2259418A1 (en) * 1996-07-11 1998-01-22 Farmarc Nederland B.V. Pharmaceutical composition containing acid addition salt of basic drug
DE19646392A1 (en) * 1996-11-11 1998-05-14 Lohmann Therapie Syst Lts Preparation for use in the oral cavity with a layer containing pressure-sensitive adhesive, pharmaceuticals or cosmetics for dosed delivery
US20040023948A1 (en) * 1997-03-24 2004-02-05 Green Richard David Fast-dispersing dosage form containing 5-HT1 agonists
GB9706089D0 (en) * 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
TW586934B (en) * 1997-05-19 2004-05-11 Sumitomo Pharma Immunopotentiating composition
US6197331B1 (en) 1997-07-24 2001-03-06 Perio Products Ltd. Pharmaceutical oral patch for controlled release of pharmaceutical agents in the oral cavity
US6177282B1 (en) * 1997-08-12 2001-01-23 Mcintyre John A. Antigens embedded in thermoplastic
GB9717770D0 (en) * 1997-08-21 1997-10-29 Scherer Ltd R P Pharmaceutical composition
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US6074674A (en) * 1997-10-31 2000-06-13 University Of Kentucky Research Foundation Formulations for sustained-release of topical anesthetics and methods of making and using same
US7070799B1 (en) * 1998-02-10 2006-07-04 Generex Pharmaceuticals, Inc. Method for administering insulin to the buccal region
US6221378B1 (en) 1998-02-10 2001-04-24 Generex Pharmaceuticals Incorporated Mixed micellar delivery system and method of preparation
US5990134A (en) * 1998-08-12 1999-11-23 Taylor Pharmaceuticals Oral droperidol compositions and method for treating migraine
US5981552A (en) * 1998-10-23 1999-11-09 Taylor Pharmaceuticals Sublingual and buccal compositions of droperidol and method for treating migraine
US5997884A (en) * 1998-02-12 1999-12-07 Taylor Pharmaceuticals Compositions and method for treating migraine
US20030091629A1 (en) * 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
US6974590B2 (en) * 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
US6103257A (en) * 1998-07-17 2000-08-15 Num-Pop, Inc. System for delivering pharmaceuticals to the buccal mucosa
US6368625B1 (en) 1998-08-12 2002-04-09 Cima Labs Inc. Orally disintegrable tablet forming a viscous slurry
ATE252889T1 (en) * 1998-08-19 2003-11-15 Skyepharma Canada Inc INJECTABLE AQUEOUS PROPOFOL DISPERSIONS
US6358060B2 (en) 1998-09-03 2002-03-19 Jsr Llc Two-stage transmucosal medicine delivery system for symptom relief
US6344222B1 (en) 1998-09-03 2002-02-05 Jsr Llc Medicated chewing gum delivery system for nicotine
SE9803239D0 (en) * 1998-09-24 1998-09-24 Diabact Ab Composition for the treatment of acute pain
SE9803240D0 (en) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
US6294153B1 (en) 1998-12-21 2001-09-25 Generex Pharmaceuticals, Inc. Aerosol pharmaceutical formulation for pulmonary and nasal delivery
US6884792B2 (en) * 1999-01-08 2005-04-26 Marvin B. Bacaner Bretylium compositions and kits and their use in preventing and treating cardiovascular conditions
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
US6270781B1 (en) 1999-01-08 2001-08-07 Maxim Pharmaceuticals, Inc. Method and compositions for topical treatment of damaged tissue using reactive oxygen metabolite production or release inhibitors
WO2000040232A2 (en) 1999-01-08 2000-07-13 Bacaner Marvin B Bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
US6552024B1 (en) 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US7658938B2 (en) 1999-02-22 2010-02-09 Merrion Reasearch III Limited Solid oral dosage form containing an enhancer
US20070148228A1 (en) * 1999-02-22 2007-06-28 Merrion Research I Limited Solid oral dosage form containing an enhancer
US8119159B2 (en) * 1999-02-22 2012-02-21 Merrion Research Iii Limited Solid oral dosage form containing an enhancer
US6350432B1 (en) 1999-03-19 2002-02-26 Generex Pharmaceuticals Incorporated Pressurized container having an aerosolized pharmaceutical composition
US6248760B1 (en) * 1999-04-14 2001-06-19 Paul C Wilhelmsen Tablet giving rapid release of nicotine for transmucosal administration
AU5871000A (en) * 1999-06-11 2001-01-02 Paul G. Abrams High dose radionuclide complexes for bone marrow suppression
DE19932603A1 (en) 1999-07-13 2001-01-25 Gruenenthal Gmbh Multi-layer film containing active substance made of in-situ cross-linked hydrophilic polymers
AU6528400A (en) 1999-08-23 2001-03-19 David M. Ockert Triple drug therapy for the treatment of narcotic and alcohol withdrawal symptoms
EP1255565A1 (en) * 2000-01-13 2002-11-13 MERCK PATENT GmbH Pharmaceutical preparations containing 2-pyrrolidone as the dissolving intermediary
AU2001261744A1 (en) * 2000-05-19 2001-12-03 Npd Llc Chewing gums, lozenges, candies, tablets, liquids, and sprays for efficient delivery of medications and dietary supplements
US6526993B1 (en) * 2000-09-12 2003-03-04 Eugene C. Wagner Dental implement with comfit grip
US6365215B1 (en) * 2000-11-09 2002-04-02 International Flavors & Fragrances Inc. Oral sensory perception-affecting compositions containing dimethyl sulfoxide, complexes thereof and salts thereof
US20020106407A1 (en) * 2000-12-11 2002-08-08 Dennis Coleman Method and apparatus for treating breakthrough pain
US20020160043A1 (en) * 2001-02-27 2002-10-31 Dennis Coleman Compositions and method of manufacture for oral dissolvable dosage forms
US20030118628A1 (en) * 2001-04-05 2003-06-26 Tutuncu Nurhan Pinar Confectionery product having a salivation region and an oral comfort region
EP1390383B1 (en) 2001-05-11 2012-02-29 Isis Pharmaceuticals, Inc. Antisense permeation enhancers
HUP0401022A3 (en) * 2001-08-14 2006-11-28 Biotie Therapies Corp Method for the preparation of pharmaceutical compositions containing opioid antagonist for treating alcoholism or alcohol abuse
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
US20030049304A1 (en) * 2001-08-29 2003-03-13 Somani Jitendra Krishan Quiescently frozen ice products
IL160928A0 (en) * 2001-10-19 2004-08-31 Maxim Pharm Inc Use of histamine to treat liver disease
EP1448127A1 (en) * 2001-11-06 2004-08-25 Maxim Pharmaceuticals, Inc. Compositions for the treatment of infectious diseases
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
EP1534302A4 (en) * 2002-08-22 2009-01-07 Nutrition 21 Inc Arginine silicate inositol complex and use thereof
US6592908B1 (en) 2002-09-23 2003-07-15 Albert Crum Nutritional or therapeutic compositions
US20040115244A1 (en) * 2002-12-17 2004-06-17 Holgate Eric Jamison Methods and compositions for nicotine replacement therapy
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
US20080213363A1 (en) * 2003-01-23 2008-09-04 Singh Nikhilesh N Methods and compositions for delivering 5-HT3 antagonists across the oral mucosa
US20040253307A1 (en) * 2003-02-04 2004-12-16 Brian Hague Sugar-free oral transmucosal solid dosage forms and uses thereof
US20060062812A1 (en) * 2003-03-11 2006-03-23 Calvin Ross Novel compositions
US6966252B2 (en) 2003-03-31 2005-11-22 Mcneil-Ppc, Inc. Hydrophilic substance dispensing device
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
BRPI0302736B8 (en) 2003-06-02 2021-05-25 Ems S/A pharmaceutical composition based on ketorolac or one of its pharmaceutically acceptable salts for sublingual use
WO2005004989A2 (en) * 2003-07-01 2005-01-20 Todd Maibach Film comprising therapeutic agents
WO2005018565A2 (en) * 2003-08-21 2005-03-03 Transoral Pharmaceuticals, Inc. Compositions for delivering 5-ht agonists across the oral mucosa and methods of use thereof
US20050042281A1 (en) * 2003-08-21 2005-02-24 Singh Nikhilesh N. Compositions for delivering therapeutic agents across the oral mucosa
US7282217B1 (en) 2003-08-29 2007-10-16 Kv Pharmaceutical Company Rapidly disintegrable tablets
US8627828B2 (en) * 2003-11-07 2014-01-14 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US8469036B2 (en) 2003-11-07 2013-06-25 U.S. Smokeless Tobacco Company Llc Tobacco compositions
US20050171192A1 (en) * 2003-12-11 2005-08-04 Gehlsen Kurt R. Use of histamine to treat bone disease
CA2549642C (en) * 2003-12-31 2012-10-30 Cima Labs Inc. Effervescent oral opiate dosage forms and methods of administering opiates
WO2005065317A2 (en) * 2003-12-31 2005-07-21 Cima Labs Inc. Effervescent oral fentanyl dosage form
EA010826B1 (en) * 2003-12-31 2008-12-30 Сайма Лэбс Инк. Fentanyl dosage form for oral administration, methods of making thereof and methods of treatment
KR20150038745A (en) * 2004-02-17 2015-04-08 트랜스셉트 파마슈티칼스, 인코포레이티드 Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof
WO2006009975A2 (en) * 2004-06-22 2006-01-26 Maxim Pharmaceuticals, Inc. Histamine to treat disorders affecting muscle function
US20060004035A1 (en) * 2004-06-25 2006-01-05 Cephalon, Inc. System for identification of a pharmaceutical product
US20060029665A1 (en) * 2004-08-03 2006-02-09 Transoral Pharmaceuticals, Inc. Pilocarpine compositions and methods of use thereof
WO2006073514A2 (en) * 2004-08-25 2006-07-13 Tufts University Compositions, methods and kits for repressing virulence in gram positive bacteria
US20060051413A1 (en) * 2004-09-08 2006-03-09 Chow Sing S M Method of enhancing absorptions of transmucosal administration formulations
US20050196517A1 (en) * 2005-02-14 2005-09-08 Mars, Incorporated Edible product having discrete regions with different heats of solution
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US8242131B2 (en) * 2005-05-25 2012-08-14 Transcept Pharmaceuticals, Inc. Methods of treating middle-of-the-night insomnia
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070104763A1 (en) * 2005-11-10 2007-05-10 Navinta Llc Composition of fentanyl citrate oral solid transmucosal dosage form, excipient and binding material therefore, and methods of making
US8679545B2 (en) * 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8202535B2 (en) * 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US9066847B2 (en) * 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
CN101437522A (en) * 2006-04-07 2009-05-20 默里昂研究Ⅲ有限公司 Solid oral dosage form containing an enhancer
US20070260491A1 (en) * 2006-05-08 2007-11-08 Pamela Palmer System for delivery and monitoring of administration of controlled substances
WO2007143674A2 (en) * 2006-06-05 2007-12-13 Verus Pharmaceuticals, Inc. Methods for buccal, lingual or sublingual dosing regimens of epinephrine for the treatment of allergic emergencies
WO2007146234A2 (en) * 2006-06-09 2007-12-21 Merrion Research Ii Limited Solid oral dosage form containing an enhancer
US20070299687A1 (en) * 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
BRPI0714712B8 (en) 2006-07-21 2021-05-25 Biodelivery Sciences Int Inc drug delivery device
US8642016B2 (en) * 2006-07-21 2014-02-04 Jsrnti, Llc Medicinal delivery system, and related methods
US8158609B1 (en) 2006-11-02 2012-04-17 Novartis Ag Use of cyclodextrins as an active ingredient for treating dry AMD and solubilizing drusen
US20090214442A1 (en) * 2006-12-01 2009-08-27 Cephalon, Inc. Oral Transmucosal Nicotine Dosage Form
JP2010511611A (en) * 2006-12-01 2010-04-15 シマ ラブス インク． Oral transmucosal nicotine dosage form
EP1938756A1 (en) * 2006-12-29 2008-07-02 Qiagen GmbH Method and materials for triggered release of a biological sample
EP2112923A1 (en) 2007-01-22 2009-11-04 Targacept Inc. Intranasal, buccal, and sublingual administration of metanicotine analogs
AU2008216867B2 (en) 2007-02-09 2014-01-30 Durect Corporation Transoral dosage forms comprising sufentanil and naloxone
US20100215774A1 (en) * 2007-02-09 2010-08-26 Todd Maibach Film comprising nitroglycerin
MX2009013384A (en) * 2007-06-08 2010-01-25 Addrenex Pharmaceuticals Inc Extended release formulation and method of treating adrenergic dysregulation.
US20100172991A1 (en) * 2007-06-08 2010-07-08 Henry Joseph Horacek Extended Release Formulation and Methods of Treating Adrenergic Dysregulation
US20090004254A1 (en) * 2007-06-19 2009-01-01 Todd Maibach Film comprising active drugs
EP2025332A1 (en) * 2007-08-13 2009-02-18 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Clay-based aromatised therapeutic composition
US20090143343A1 (en) * 2007-11-13 2009-06-04 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
US20100216754A1 (en) * 2007-11-13 2010-08-26 Meritage Pharma, Inc. Compositions for the treatment of inflammation of the gastrointestinal tract
DK2214679T3 (en) 2007-11-13 2019-05-20 Meritage Pharma Inc CORTICOSTEROID COMPOSITIONS
US20090123551A1 (en) * 2007-11-13 2009-05-14 Meritage Pharma, Inc. Gastrointestinal delivery systems
US20090264392A1 (en) * 2008-04-21 2009-10-22 Meritage Pharma, Inc. Treating eosinophilic esophagitis
BRPI0912384A2 (en) * 2008-05-07 2015-10-13 Merrion Res Iii Ltd composition and method for preparing a composition
CA2726259C (en) 2008-06-04 2014-07-29 Colgate-Palmolive Company Oral care implement with cavitation system
US20100055050A1 (en) * 2008-08-30 2010-03-04 Kathleen Moore Nicotine chewing gum on a stick
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
US20100190739A1 (en) * 2008-12-15 2010-07-29 Fleming And Company, Pharmaceuticals Rapidly Dissolving Vitamin Formulation and Methods of Using the Same
US20100215743A1 (en) * 2009-02-25 2010-08-26 Leonard Thomas W Composition and drug delivery of bisphosphonates
US20110097401A1 (en) * 2009-06-12 2011-04-28 Meritage Pharma, Inc. Methods for treating gastrointestinal disorders
CN108295241A (en) 2009-06-18 2018-07-20 宁静制药公司 The desmopressin administration of safety
US8475832B2 (en) * 2009-08-07 2013-07-02 Rb Pharmaceuticals Limited Sublingual and buccal film compositions
AU2010314994B2 (en) 2009-11-09 2016-10-06 Spotlight Technology Partners Llc Fragmented hydrogels
WO2011057131A1 (en) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Polysaccharide based hydrogels
US20110182985A1 (en) * 2010-01-28 2011-07-28 Coughlan David C Solid Pharmaceutical Composition with Enhancers and Methods of Preparing thereof
WO2011120033A1 (en) * 2010-03-26 2011-09-29 Merrion Research Iii Limited Pharmaceutical compositions of selective factor xa inhibitors for oral administration
US8623409B1 (en) 2010-10-20 2014-01-07 Tris Pharma Inc. Clonidine formulation
KR20140026354A (en) 2011-01-07 2014-03-05 메리온 리서치 Ⅲ 리미티드 Pharmaceutical compositions of iron for oral administration
BR112014003651B1 (en) 2011-08-18 2022-03-29 Biodelivery Sciences International, Inc Misuse-resistant mucoadhesive devices for the release of buprenorphine
SI2915525T1 (en) 2011-09-19 2022-01-31 Orexo Ab Sublingual abuse-resistant tablets comprising buprenorphine and naloxone
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
CA2860231A1 (en) 2011-12-28 2013-07-04 Pozen Inc. Improved compositions and methods for delivery of omeprazole plus acetylsalicylic acid
NZ701428A (en) 2012-05-02 2016-10-28 Orexo Ab New alfentanil composition for the treatment of acute pain
US20160051496A1 (en) * 2014-08-20 2016-02-25 Tsu-I Catherine Wang Oral Transmucosal Compositions Including C-SERMs for Treating Female Infertility
US20160051495A1 (en) * 2014-08-20 2016-02-25 Professional Compounding Centers Of America Oral Transmucosal Compositions including C-SERMs for Low Testosterone Levels in Men
EP3193824B1 (en) 2014-08-29 2023-07-05 The ProImmune Company, LLC A composition for use in treating hyperlipidemia, hypercholesterolemia and/or hypertriglyceridemia via physiologically synthesised glutathione
WO2016120378A1 (en) 2015-01-29 2016-08-04 Novo Nordisk A/S Tablets comprising glp-1 agonist and enteric coating
US9744239B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9744209B2 (en) 2015-01-30 2017-08-29 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9687526B2 (en) 2015-01-30 2017-06-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9937223B2 (en) 2015-01-30 2018-04-10 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9925233B2 (en) 2015-01-30 2018-03-27 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US9750785B2 (en) 2015-01-30 2017-09-05 Par Pharmaceutical, Inc. Vasopressin formulations for use in treatment of hypotension
US11191735B2 (en) 2015-03-13 2021-12-07 Nutrition 21, Llc Arginine silicate for periodontal disease
US20170135969A1 (en) 2015-11-12 2017-05-18 Jds Therapeutics, Llc Topical arginine-silicate-inositol for wound healing
MX2019002468A (en) 2016-09-01 2019-09-18 Jds Therapeutics Llc Magnesium biotinate compositions and methods of use.
GB201709141D0 (en) 2017-06-08 2017-07-26 Klaria Pharma Holding Ab Pharmaceutical formulation
WO2020092431A1 (en) 2018-11-02 2020-05-07 Nutrition 21, Llc Compositions containing inositol-stabilized arginine silicate complexes and inositol for improving cognitive function in video gamers
GB2613672A (en) 2019-12-16 2023-06-14 Nutrition 21 Llc Methods of production of aginine-silicate complexes
US11918689B1 (en) 2020-07-28 2024-03-05 Tris Pharma Inc Liquid clonidine extended release composition

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US122507A (en) * 1872-01-02 Improvement in medical compounds or worm-candies
US1971560A (en) * 1928-10-22 1934-08-28 Parker Meyer Dennis Company Candy and holder therefor
US2096611A (en) * 1935-02-07 1937-10-19 Parker Meyer Dennis Company Confection
US2208120A (en) * 1938-03-02 1940-07-16 William B Coleman Pharmaceutical preparation and method of making same
US2246778A (en) * 1939-12-21 1941-06-24 Edward E Cahoon Safety handle for confections
US2295042A (en) * 1941-08-25 1942-09-08 Robert L Llewellyn Fish plug
GB550296A (en) * 1941-11-17 1943-01-01 British Oxygen Co Ltd Improvements in or relating to the administration of inhalant gas mixtures
US2323656A (en) * 1942-07-28 1943-07-06 Helfenstein John Fishhook
US2508560A (en) * 1946-10-22 1950-05-23 Mozel A Adams Fishing lure
GB628709A (en) * 1947-10-06 1949-09-02 William Edmondson An appliance for the production and administration of gas-vapour mixtures
US2488272A (en) * 1948-08-06 1949-11-15 Harry E Davis Cellophane stick and method of making it
US2469589A (en) * 1948-09-20 1949-05-10 Toy Pop Corp Confection with support therefor
GB646680A (en) * 1948-10-27 1950-11-29 William Edmondson Apparatus for mixing the vapour of a volatile anaesthetic with air
US2915061A (en) * 1956-12-24 1959-12-01 Cyprane Ltd Volatile anaesthetic vaporising apparatus
US2926121A (en) * 1957-03-20 1960-02-23 American Home Prod Therapeutic candy-like product and its preparation
US2857908A (en) * 1957-04-26 1958-10-28 Leslie S Cornfield Candy coated tongue depressor
US2897624A (en) * 1958-06-27 1959-08-04 Frederick O Yakel Conservation fishhooks
US2963404A (en) * 1958-09-05 1960-12-06 Pfizer & Co C Tannate candy making, and product
US3210247A (en) * 1960-04-16 1965-10-05 Anti-epileptic i-cyclohexyl-z-methyl- aiviino propane salt of phenyl ethyl barbituric acid
CH410963A (en) * 1960-07-28 1966-04-15 Hommel Ag Process for the preparation of 5-allyl-5- (B-oxypropyl) barbituric acid
GB968054A (en) * 1962-02-15 1964-08-26 Cyprane Ltd Improvements in volatile anaesthetic vaporising apparatus
US3114642A (en) * 1962-04-20 1963-12-17 Corn Products Co Hard candy and process for making same
US3264115A (en) * 1962-07-10 1966-08-02 Harry E Davis Safety lollipop
US3493652A (en) * 1962-09-14 1970-02-03 Charles W Hartman Controlled release medicament
US3271256A (en) * 1963-03-21 1966-09-06 Richardson Merrell Inc Chloroform in hard candy
US3172179A (en) * 1963-08-12 1965-03-09 John V Schafer Collar fastener
GB1083896A (en) * 1964-04-30 1967-09-20 Dunster Lab Ltd Vehicles for administering drugs
GB1071659A (en) * 1964-06-09 1967-06-07 Cyprane Ltd Improvements in or relating to volatile anaesthetic vaporising apparatus
US3344030A (en) * 1964-06-15 1967-09-26 American Home Prod Reinforced directly compressed nongranulated pharmaceutical crystalline lactose tables
US3341414A (en) * 1964-08-27 1967-09-12 Merck & Co Inc N-cyclohexylsulfamate solubilized medication
GB1171691A (en) * 1967-02-24 1969-11-26 Forest Laboratories Lond-Acting Oral Carrier
US3438787A (en) * 1967-03-09 1969-04-15 Atlas Chem Ind Sugarless confection
US3418743A (en) * 1967-05-02 1968-12-31 Roy H. Halvorsen Fish lure with retractable hooks
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3556811A (en) * 1969-08-11 1971-01-19 Walton J Smith Low-fermentability hard candy
US3697641A (en) * 1970-01-02 1972-10-10 Gerhard W Ahrens Nonhygroscopic non-sugarbase noncariogenic-vitamin c releasable base material for use in the preparation of suckable tablets,lozenges and chocolate
US3622352A (en) * 1970-04-30 1971-11-23 Philip Morris Inc Edible compositions and method for coating them
US3996934A (en) * 1971-08-09 1976-12-14 Alza Corporation Medical bandage
US3738845A (en) * 1972-01-07 1973-06-12 Pfizer Process for the manufacture of sugarless confections
FI50578C (en) * 1972-09-05 1976-05-10 Haemeen Anttila Yrjoe Sakari Pull fitted with sliding hooks
US3867927A (en) * 1974-06-13 1975-02-25 Patrick F Hergott Tongue blade sucker
US3943928A (en) * 1974-09-25 1976-03-16 Lariccia Anthony H Eliminating the safety hazard in oral dissolution of a solid
US4131648A (en) * 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US4093709A (en) * 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4168308A (en) * 1976-03-12 1979-09-18 Apoteksvarucentralen Vitrum Ab Composition for enhancing the administration of pharmacologically active agents
US4060084A (en) * 1976-09-07 1977-11-29 Alza Corporation Method and therapeutic system for providing chemotherapy transdermally
DE2712161C2 (en) * 1977-03-19 1983-01-05 Blendax-Werke R. Schneider Gmbh & Co, 6500 Mainz Dental and oral care products
DD132404B1 (en) * 1977-08-12 1983-04-27 Roland Schubert METHOD FOR PRODUCING A MEDICAL DEVICE
US4139627A (en) * 1977-10-06 1979-02-13 Beecham Inc. Anesthetic lozenges
EP0001907B1 (en) * 1977-11-07 1981-02-11 Beecham Inc. Anaesthetic lozenges and method of preparing them
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
US4225627A (en) * 1979-01-08 1980-09-30 A. E. Staley Manufacturing Company Demolding confections with steam
GB2042888B (en) * 1979-03-05 1983-09-28 Teijin Ltd Preparation for administration to the mucosa of the oral or nasal cavity
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4307075A (en) * 1979-09-13 1981-12-22 American Home Products Corporation Topical treatment of aphthous stomatitis
US4241092A (en) * 1979-10-26 1980-12-23 General Foods Corporation Gasified candy dispersed in a matrix of sorbitol
US4335147A (en) * 1980-03-12 1982-06-15 Helmut Sollich Method for making confections
US4311722A (en) * 1980-07-11 1982-01-19 Life Savers, Inc. High fructose hard candy
JPS5758615A (en) * 1980-09-26 1982-04-08 Nippon Soda Co Ltd Film agnent and its preparation
JPS5843368B2 (en) * 1980-10-30 1983-09-27 日東電工株式会社 Anti-inflammatory analgesic patch
US4346709A (en) * 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
IL61721A (en) * 1980-12-16 1984-03-30 Blank Izhak Nitroglycerin preparations
JPS6059207B2 (en) * 1981-03-13 1985-12-24 日東電工株式会社 Manufacturing method for complex preparations
AU8533582A (en) * 1981-07-10 1984-01-12 Reckitt & Colman Products Limited Stable solutions of buprenorphine
SU1011126A1 (en) * 1981-07-14 1983-04-15 Всесоюзный научно-исследовательский и испытательный институт медицинской техники Method of treating diabetes mellitus
US4372942A (en) * 1981-08-13 1983-02-08 Beecham Inc. Candy base and liquid center hard candy made therefrom
US4452825A (en) * 1982-09-01 1984-06-05 Nabisco Brands, Inc. Sorbitol-containing hard candy
CA1208558A (en) * 1982-10-07 1986-07-29 Kazuo Kigasawa Soft buccal
US4642231A (en) * 1983-07-20 1987-02-10 Warner-Lambert Company Magnesium trisilicate suitable for preparation of medicament adsorbates of antihistamines
US4749575A (en) * 1983-10-03 1988-06-07 Bio-Dar Ltd. Microencapsulated medicament in sweet matrix
US4551329A (en) * 1984-01-20 1985-11-05 Joan Harris Oral medicament lollipop
US4863737A (en) * 1985-05-01 1989-09-05 University Of Utah Compositions and methods of manufacture of compressed powder medicaments
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4818539A (en) * 1985-02-05 1989-04-04 Warner-Lambert Company Ingestible aggregate and delivery system prepared therefrom
AU641127B2 (en) * 1985-05-01 1993-09-16 Anesta Corporation Compressed powder medicaments
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
US4671953A (en) * 1985-05-01 1987-06-09 University Of Utah Research Foundation Methods and compositions for noninvasive administration of sedatives, analgesics, and anesthetics
US4695463A (en) * 1985-05-24 1987-09-22 Warner-Lambert Company Delivery system for active ingredients and preparation thereof
US4764378A (en) * 1986-02-10 1988-08-16 Zetachron, Inc. Buccal drug dosage form
FR2611501B1 (en) * 1987-03-04 1991-12-06 Corbiere Jerome NOVEL PHARMACEUTICAL COMPOSITIONS FOR THE ORAL ROUTE BASED ON LYSINE ACETYLSALIELYLATE AND PROCESS FOR OBTAINING SAME

Also Published As

Publication number Publication date
ATE177007T1 (en) 1999-03-15
EP0490916A4 (en) 1992-08-12
ATE129148T1 (en) 1995-11-15
WO1991003237A1 (en) 1991-03-21
JPH05503917A (en) 1993-06-24
EP0490916B1 (en) 1995-10-18
AU645265B2 (en) 1994-01-13
EP0630647B1 (en) 1999-03-03
DE69032982T2 (en) 1999-08-26
JP2717024B2 (en) 1998-02-18
ES2077686T3 (en) 1995-12-01
DK0490916T3 (en) 1996-03-04
NO304348B1 (en) 1998-12-07
NO920857D0 (en) 1992-03-04
CA2066423C (en) 1998-04-14
DE69023143D1 (en) 1995-11-23
DE69032982D1 (en) 1999-04-08
DE69023143T2 (en) 1996-03-28
EP0630647A1 (en) 1994-12-28
EP0490916A1 (en) 1992-06-24
NO920857L (en) 1992-04-06
AU668004B2 (en) 1996-04-18
DK0630647T3 (en) 1999-10-04
US5288497A (en) 1994-02-22
AU5521894A (en) 1994-04-28
AU6287790A (en) 1991-04-08
ES2133448T3 (en) 1999-09-16

Similar Documents

Publication Publication Date Title
CA2066423A1 (en) Compositions and methods of manufacture of oral dissolvable medicaments
CA2024502A1 (en) Dosage form for administering oral hypoglycemic glipizide
CA2066403A1 (en) Transmucosal dosage form
AP9400645A0 (en) Thermal infusion process for preparing controlled release solid dosage forms of medicaments for oral administration and controlled release sold dosage forms of medicaments prepared thereby.
EP0381194A3 (en) Drug preparation applicable to oral mucosa
AU6060896A (en) Oral 1alpha-hydroxyprevitamin D
AU5288690A (en) A preparation intended to prevent the emission of mercury from amalgam fillings and a method with the same aim
HU900884D0 (en) Process for preparation of piperidine derivatives and producing of therapeutic compositions comprising the compounds
AU7921887A (en) Therapeutic agents
IT1204901B (en) COMPOSITIONS CONTAINING USNIC ACID OR ITS DERIVATIVES SUITABLE FOR USE IN THE TREATMENT OF TOOTH DECAY
AU1536888A (en) Dental cortical plate perforator
AU6442590A (en) Device for oral administration of an active principle for preventive treatment of caries in babies
HU9200385D0 (en) Megacariocitopoietic factor
GR3006174T3 (en)
KR950013453B1 (en) Composition containing 15-deoxisper gualine
USD239942S (en)
CA2101548A1 (en) Acylamino-alkylidenhydroxy-bisphosphonic acids useful in the therapy of osteoarticular diseases
IL100128A0 (en) Pharmaceutical compositions containing an imidazobenzodiazepine
HUT59593A (en) Process for producing pharmaceutical composition
ES2027507A6 (en) Selenophen derivatives, a preparation process of the same and therapeutical compositions containing them
BG52004B2 (en) Medicament for the treatment of inflammatory impairments of the alveolar bone and the oral mucous membrane

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry