CA2071146C - Taste preserving, mild oral hygiene compositions - Google Patents
Taste preserving, mild oral hygiene compositionsInfo
- Publication number
- CA2071146C CA2071146C CA002071146A CA2071146A CA2071146C CA 2071146 C CA2071146 C CA 2071146C CA 002071146 A CA002071146 A CA 002071146A CA 2071146 A CA2071146 A CA 2071146A CA 2071146 C CA2071146 C CA 2071146C
- Authority
- CA
- Canada
- Prior art keywords
- weight
- sulfosuccinate
- oral hygiene
- amount
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/92—Oral administration
Abstract
This invention relates to a mild oral hygiene composition such as a toothpaste, dental gel, mouthrinse or toothpowder containing a mild surfactant, protein fatty acid condensate or acid hydrolyzed, hydrolyzed animal protein or the mixtures thereof, and in combination therewith, mild high foaming surfactant, e.g., disodium cocoamido MIPA sulfosuccinate or disodium oleamido PEG-2 sulfosuccinate or disodium lauryl sulfosuccinate or the mixtures thereof; or a natural emulsifier, e.g., lecithin, or both a mild surfactant and a natural emulsifier.
Description
207114~
TASTE ~K~ iKVING, MILD ORAL HYGIENE COMPOSITIONS
The surfactant in dental hygiene products serves many purposes. T~ey are used for their detersive, emulsifying and antimicrobial properties in addition to their foaming character. Many consumers believe that high foam and rapid break-up indicate a superior cleaning ability.
The most commonly used surfactant in marketed dentifrices is sodium lauryl sulfate. It is readily available at low cost and generates a high foam. However, inclusion of this detergent in a dentifrice formulation requires the addition of high levels of costly flavor oils to mask the bitter taste of sodium lauryl sulfate itself.
Sodium lauryl sulfate also has been accused of generating a so called ~orange juice effect~. This effect may be detected as an unpleasant residual flavor note left in the mouth following the ingestion of orange juice after toothbrushin~ with a toothpaste containing the sodium lauryl sulfate. ~ndeed, in psychophysical evaluation of the effect of sodium lauryl sulfate on the taste of citric acid, it was determined that the surfactant added a distinctly bitter component to the usual sour taste of citric acid. In addition, it is also known that sodium lauryl sulfate and flavor oils are severe dermal irritants.
Therefore, it would be advantageous to replace sodium lauryl sulfate with a surfactant or a combination of surfactants, which possess a mild taste, a low dermal irritation potential and foaming properties comparable to the oral composition containing sodium lauryl sulfate. Furthermore, the flavor oils level for this 20~1t 4~
mild tasting dentifrice could be lowered significantly and thereby further reduce the dermal irritation potential of the oral composition and eliminate the so called "orange juice effect~.
It is an object of the present invention to provide a novel oral hygiene composition which overcomes at least one of the disadvantages of prior such oral compositions.
Accordingly, an oral hygiene composition which is free of sodium lauryl sulfate is provided comprising a protein derivative selected from the group consisting of protein fatty acid condensates and acid hydrolyzed animal proteins, together with at least one member of the group of (a) a flavor oil and a high foaming sulfosuccinate and (b) a natural emulsifier.
In accordance with this invention, imprsved oral hygiene compositions in the forms of dentifrice pastes, gels, powders and mouthrinses are pro~ided.
These compositions contain in an oral hygiene, e.g.
dental, vehicle, a protein deri~ative which may be a protein fatty acid condensate or an acid hydrolyzed animal protein, and at least one high foaming mild surfactant such as a sulfosuccinate and a natural emulsifier, e.g., lecithin. Suitably, the protein fatty acid condensate is potassium coco-hydrolyzed collagen or triethanolamine coco-hydrolyzed collagen acid and the acid hydrolyzed animal protein is collagen peptide; and the high foaming mild surfactant is suitably disodium oleamido PEG-2 sulfosuccinate, disodium cocoamido MIPA sulfosuccinate or disodium lauryl sulfosuccinate or mixtures thereof.
~ hen the comrosition does not contain lecithin, a flavor oil is incorporated. In 207~
compositions containing lecithin, a flavor oil may optionally be included. Lecithin, in addition to enhancing the dispersion of the flavor oil, improves the flavor impact in the oral environment.
The preferred compositions of this invention suitably comprise:
A) from about 0.01% to about 4.00% of a mild surfactant, a protein fatty acid co~encate having an average molecular weight from about 650 to about 900 or an acid hydrolyzed animal protein having an average molecular weight from about 500 to about 2000 or mixtures thereof;
B) from about 0.01% to about 1.5% of a high foaming mild surfactant, e.g.~ a sulfosuccinate.
C) from about 0.01% to about 5.00~ of a natural emulsifier, lecithin, to enhance the dispersion of the flavor oils in the dentifrice and to improve the flavor impact in the oral cavity;
D) from 0 to about 1.0%, preferably from about 0.01 to 1.0%, and most preferably, from 0.01 to 0.45% of a flavor oil.
All percentages given are percentages by weight of the fully compounded oral composition.
The compositions contemplated include toothpastes and dental gels wherein the preferred protein derivatives are potassium coco-hydrolyzed collagen, triethanolamine coco-hydrolyzed collagen and acid hydrolyzed collagen peptide, and the preferred high foaming sulfosuccinates are disodium oleamido PEG-2 sulfosuccinate and disodium cocoamido MIPH
sulfosuceinate; toothpowders wherein the preferred protein derivative is collagen peptide and the 207114~
preferred high foaming sulfosuccinate is disodium lauryl sulfosuccinate; and mouthrinses wherein the preferred protein derivative are potassium coco-hydrolyzed collagen and triethanolamine coco-hydrolyzed collagen. Also contemplated are toothpastes containing polyoxyethylene (40) stearate as a foam stabilizer.
The pre~erred mild oral hygiene compositions of this invention, such as toothpaste, dental gels, toothpowders, and mouthrinses comprise a mild surfactant system and a natural emulsifier, e.g., lecithin. The mild surfactant system contains at least one protein fatty acid co~encate or one acid hydrolyzed animal protein or mixtures thereof, from about 0.01% to about 4.0% by weight, optionally, in combination with a sulfosuccinate surfactant, from about 0.01% to about 1.5% by weight, to improve the foam density.
~ he protein fatty acid con~encates are considered to be anionic surfactants having an average molecular weight from about 650 to about 900 and having a general chemical formula:
H3C-(Cx2)lo-s-(NH-cH-~j4-ox R: Amino acid side chain of collagen X: Potassium, or triethanolamine The acid hydrolyzed animal proteins are considered to be cationic surfactants preferred as an acid hydrolyzed collagen having an average molecular 20711~
weight from about 500 to about 2000 and having a general chemical formula: ' H2N-~-C~-(NH ~CH ~~)n I S
R O R O R O
R: Amino acid side chain of collagen X: Hydrogen, sodium n- 8-11 The sulfosuccinate surfactants are disodium oleamido PEG-2 sulfosuccinate, disodium cocamido MIPA
su}fosuccinate and disodium lauryl sulfosuccinate having the general formula:
~H2 C~S03Na C02Na R: Fatty alcohol, ethoxylated fatty alcohol or fatty ~ nolamide The total amount of the mild surfactant system referred to above in the oral composition herein is from about 0.02% to about 5.50% by weight of the said oral composition, preferably, in the range of 0.5%
to 3.5%. When a sulfosuccinate surfactant is incorporated into the oral composition to increase the foam density, the ratio of the hydrolyzed animal protein and sulfosuccinate surfactant should be in the range of 0.01 to 20, preferably in the range of 0.1 to 15.
The emulsifier employed according to this invention as an optional component i'n dispersing flavor oils in the oral composition is preferably soybean lecithin, a natural emulsifier, having an approximate HL3 of 7 and a chemical formula:
C~I20COR
r~oCOR
CH2~-P~ -OCH2cH2N (CH3)3 R: Hydrogen or alkyl group The amount of lecithin referred to above in the oral composition is suitably from about 0.01% to about 5.00% by weight of the said oral composition, preferably, from about 0.10% to about 2.00%. --Other ingredients commonly used in typicaldentifrice compositions may include, but are not limited to, water, humectants, sweeteners, colors, opacifiers, abrasives, preservatives, thickeners and pharmacologically active ingredients such as water soluble fluoride, plaque and calculus inhibitors, antimicrobial agents, and dasensitizin~ compounds.
The sources of fluoride ions are well known in the art as anticaries agents. They are inorganic fluoride salts, such as sodium fluoride, stannous fluoride, sodium monofluorophosphate and the mixtures thereof. The amount of fluoride compounds, generally is from about 0.005% to about 3.00%, which releases from about 50 to about 3000 ppm of fluoride ion by weight of the oral composition.
2~71~
The liquid vehicle of the dentifrice pastes or gels may comprise water, humectants and thickening agents, in the amount from about 20.0% to about 90.0 by weight of the said composition. Examples of the suitable humectants are glycerine, sorbitol, yropylene glycol, polyethylene glycol and the mixtures thereof.
Examples of suitable thickening agents are modified cellulose products such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose, etc., and inorganic gel forming ingredients such as silica precipitates, colloidal magnesium aluminum carrageenan, alginates, etc. also are useful thickening agents.
The amount of the abrasive or polishiny agents in dentifrices is generally from about 15.0% to about 9~.0% by weight of the oral composition, preferably from about 15.0~ to about 80.0% in paste and gel and from about 65.0% to about 98.0% in toothpowder.
Examples of these materials are water-insoluble sodium metaphosphate, potassium metaphosphate, disbasic calcium phosphate anhydrous, dibasic calcium phosphate dihydrate, calcium carbonate, hydrated alumina, etc.
In clear gels, the preferred abrasive agents are colloidal silica and alkali metal alumino-silicate since they have refractive indices close to the refractive indices of the liquid gelling agents.
Typical flavor oils suitable for this invention include peppermint, spearmint, cinnamon, anethole, vanilla, lemon, orange and the like, at the levels from about 0.01% to about 1.0%. I~ is the particular feature of the invention that the flavor oil level for this mild tasting oral composition is 2 ~
significantly lower than the flavor levels in other typical oral c- ,~citions containing sodium lauryl sulfate.
In order to achieve cosmetically acceptable dentifrices gels and pastes, it is also useful to incorporate a colorant and a preservative.
The following examples further describe and provide preferred embodiments within the teachings of the invention and are solely for the purpose of illustration and are not to be considered as limitation of this invention.
EXAMPLES I - III
The following are dental gels of the present invention.
Weight (%) In~redient I II III
Water 12~5112.51 13.41 Glycerine 10.0010.00 10.00 Sorbitol (70%) 43.0043.00 43.00 Sodium carboxymethyl 0.90 0.90 0.90 celulose Sodium fluoride 0.24 0.24 0.24 Hydrated silica 30.0030.00 30.00 Potassium coco-hydrolyzed1.50 collagen (40%) Triethanolamine coco- 1.50 hydrolyzed collagen (40%) Collagen peptide 0.80 Disodium oleamido 0.20 PEG-2 sulfosuccinate Disodium cocoamido 0.20 MIPA sulfosuccinate Lecithin 0.40 0.40 0.40 Sodium saccharin 0.15 0.15 0.15 Methyl paraben 0.20 0.20 0.20 Dye solution (1.0%) 0.70 0.70 0.70 Flavor 0.20 0.20 0.20 2~7~
~XAMPLES IV - VI
The following are toothpastes representa-tive of the present invention.
Weight (%) Inqredient IV V VI
Water 24.85 24.90 24.85 Glycerine 16.00 16.00 16.00 Sorbitol (70%) 16.00 16.00 16.00 Natrosol 1.35 1.30 1.30 Sodium monofluorophosphate 0.80 0.80 0.80 Dicalcium phosphate anhydrous 7.00 7.00 7.00 Dicalcium phosphate 30.00 30.00 30.00 dihydrate 30.00 30.00 30.00 Aerosil 0.70 0.70 0.70 Potassium coco-hydrolyzed1.50 1.50 collayen (40%) Triethanolamine coco- 1.50 collagen peptide (40%) Disodium lauryl sulfo- 0.20 succinate Disodium oleamido 0.20 PEG-2 sulfosuccinate Disodium cocoamido 0.20 MIPA sulfosuccinate Lecithin 0.40 0.40 0.50 Sodium saccharin 0.20 0.20 0.15 Methyl paraben 0.20 0.20 0.20 Dye solution (1.0%) 0.60 0.60 0.60 Flavor 0.20 0.20 0.20 EXAMPLES VII- VIII
The following are toothpowders o~ the present invention.
Weight (~) Inqredient VII VIII
Sodium monofluorophosphate 0.80 0.80 Collagen peptide 1.00 0.80 Disodium lauryl sulfosuccinate 0.20 Hydrated silica 64.00 64.00 Dicalcium phosphate dihydrate 33.70 Calcium carbonate 33.65 Methyl paraben 0.15 0.15 Sodium saccharin 0.15 0.20 Flavor 0.20 0.20 ~7~
EXAMP~2S IX - X
The following are mouthrinses of the present invention.
Weight (%~
Inqredient IX X
Ethyl alcohol 5.00 7.00 Flavor 0.10 0.10 Glycerine 18.00 15.00 Potassium coco-hydrolyzed collagen0.50 Triethanolamine coca-hydrolyzed collagen 0.70 Lecithin 0.10 0.10 Sodium fluoride 0.02 0.02 Dye solution (1.0%) 0.10 0.10 Sodium benzoate 0.10 0.10 Water 76.03 76.88 EXAMPLES XI ~ XII
The ~ollowing are further e~amples of toothpastes of the present invention.
Weight (%) Inqredient XI XII
Water, deionized 27.89 to 27.49 42.59 to 43.09 Sodium fluoride 0.24 0.24 Methylparaben 0.12 0.12 Propylparaben 0.05 0.05 Sodium saccharin 0.30 0.20 Titanium dioxide 1.00 1.00 Polyoxyethylene (40) 2.00 2.00 stearate Fumed silica 0.60 1.20 Sorbitol 70% aqueous 12.00 12.00 solution Amorphous silica gel 26.00 14.00 Glycerin 25.00 10.00 Guar gum 0.40 0.40 Sodium carboxymethyl- 1.40 1.70 cellulose Potassium Coco- 2.00 1.50 hydrolyzed animal protein Flavor 0.60 to 1.00 0.2 to 0.7 Lecithin powder 0.30 0.30 Disodium lauryl 0.10 sulfosuccinate While certain representative embodiments and details have been shown for the pu~ose of illustrating the invention, it will be apparent to those skilled in the art that various changes may be made therein without departing from the spirit or scope of the invention.
TASTE ~K~ iKVING, MILD ORAL HYGIENE COMPOSITIONS
The surfactant in dental hygiene products serves many purposes. T~ey are used for their detersive, emulsifying and antimicrobial properties in addition to their foaming character. Many consumers believe that high foam and rapid break-up indicate a superior cleaning ability.
The most commonly used surfactant in marketed dentifrices is sodium lauryl sulfate. It is readily available at low cost and generates a high foam. However, inclusion of this detergent in a dentifrice formulation requires the addition of high levels of costly flavor oils to mask the bitter taste of sodium lauryl sulfate itself.
Sodium lauryl sulfate also has been accused of generating a so called ~orange juice effect~. This effect may be detected as an unpleasant residual flavor note left in the mouth following the ingestion of orange juice after toothbrushin~ with a toothpaste containing the sodium lauryl sulfate. ~ndeed, in psychophysical evaluation of the effect of sodium lauryl sulfate on the taste of citric acid, it was determined that the surfactant added a distinctly bitter component to the usual sour taste of citric acid. In addition, it is also known that sodium lauryl sulfate and flavor oils are severe dermal irritants.
Therefore, it would be advantageous to replace sodium lauryl sulfate with a surfactant or a combination of surfactants, which possess a mild taste, a low dermal irritation potential and foaming properties comparable to the oral composition containing sodium lauryl sulfate. Furthermore, the flavor oils level for this 20~1t 4~
mild tasting dentifrice could be lowered significantly and thereby further reduce the dermal irritation potential of the oral composition and eliminate the so called "orange juice effect~.
It is an object of the present invention to provide a novel oral hygiene composition which overcomes at least one of the disadvantages of prior such oral compositions.
Accordingly, an oral hygiene composition which is free of sodium lauryl sulfate is provided comprising a protein derivative selected from the group consisting of protein fatty acid condensates and acid hydrolyzed animal proteins, together with at least one member of the group of (a) a flavor oil and a high foaming sulfosuccinate and (b) a natural emulsifier.
In accordance with this invention, imprsved oral hygiene compositions in the forms of dentifrice pastes, gels, powders and mouthrinses are pro~ided.
These compositions contain in an oral hygiene, e.g.
dental, vehicle, a protein deri~ative which may be a protein fatty acid condensate or an acid hydrolyzed animal protein, and at least one high foaming mild surfactant such as a sulfosuccinate and a natural emulsifier, e.g., lecithin. Suitably, the protein fatty acid condensate is potassium coco-hydrolyzed collagen or triethanolamine coco-hydrolyzed collagen acid and the acid hydrolyzed animal protein is collagen peptide; and the high foaming mild surfactant is suitably disodium oleamido PEG-2 sulfosuccinate, disodium cocoamido MIPA sulfosuccinate or disodium lauryl sulfosuccinate or mixtures thereof.
~ hen the comrosition does not contain lecithin, a flavor oil is incorporated. In 207~
compositions containing lecithin, a flavor oil may optionally be included. Lecithin, in addition to enhancing the dispersion of the flavor oil, improves the flavor impact in the oral environment.
The preferred compositions of this invention suitably comprise:
A) from about 0.01% to about 4.00% of a mild surfactant, a protein fatty acid co~encate having an average molecular weight from about 650 to about 900 or an acid hydrolyzed animal protein having an average molecular weight from about 500 to about 2000 or mixtures thereof;
B) from about 0.01% to about 1.5% of a high foaming mild surfactant, e.g.~ a sulfosuccinate.
C) from about 0.01% to about 5.00~ of a natural emulsifier, lecithin, to enhance the dispersion of the flavor oils in the dentifrice and to improve the flavor impact in the oral cavity;
D) from 0 to about 1.0%, preferably from about 0.01 to 1.0%, and most preferably, from 0.01 to 0.45% of a flavor oil.
All percentages given are percentages by weight of the fully compounded oral composition.
The compositions contemplated include toothpastes and dental gels wherein the preferred protein derivatives are potassium coco-hydrolyzed collagen, triethanolamine coco-hydrolyzed collagen and acid hydrolyzed collagen peptide, and the preferred high foaming sulfosuccinates are disodium oleamido PEG-2 sulfosuccinate and disodium cocoamido MIPH
sulfosuceinate; toothpowders wherein the preferred protein derivative is collagen peptide and the 207114~
preferred high foaming sulfosuccinate is disodium lauryl sulfosuccinate; and mouthrinses wherein the preferred protein derivative are potassium coco-hydrolyzed collagen and triethanolamine coco-hydrolyzed collagen. Also contemplated are toothpastes containing polyoxyethylene (40) stearate as a foam stabilizer.
The pre~erred mild oral hygiene compositions of this invention, such as toothpaste, dental gels, toothpowders, and mouthrinses comprise a mild surfactant system and a natural emulsifier, e.g., lecithin. The mild surfactant system contains at least one protein fatty acid co~encate or one acid hydrolyzed animal protein or mixtures thereof, from about 0.01% to about 4.0% by weight, optionally, in combination with a sulfosuccinate surfactant, from about 0.01% to about 1.5% by weight, to improve the foam density.
~ he protein fatty acid con~encates are considered to be anionic surfactants having an average molecular weight from about 650 to about 900 and having a general chemical formula:
H3C-(Cx2)lo-s-(NH-cH-~j4-ox R: Amino acid side chain of collagen X: Potassium, or triethanolamine The acid hydrolyzed animal proteins are considered to be cationic surfactants preferred as an acid hydrolyzed collagen having an average molecular 20711~
weight from about 500 to about 2000 and having a general chemical formula: ' H2N-~-C~-(NH ~CH ~~)n I S
R O R O R O
R: Amino acid side chain of collagen X: Hydrogen, sodium n- 8-11 The sulfosuccinate surfactants are disodium oleamido PEG-2 sulfosuccinate, disodium cocamido MIPA
su}fosuccinate and disodium lauryl sulfosuccinate having the general formula:
~H2 C~S03Na C02Na R: Fatty alcohol, ethoxylated fatty alcohol or fatty ~ nolamide The total amount of the mild surfactant system referred to above in the oral composition herein is from about 0.02% to about 5.50% by weight of the said oral composition, preferably, in the range of 0.5%
to 3.5%. When a sulfosuccinate surfactant is incorporated into the oral composition to increase the foam density, the ratio of the hydrolyzed animal protein and sulfosuccinate surfactant should be in the range of 0.01 to 20, preferably in the range of 0.1 to 15.
The emulsifier employed according to this invention as an optional component i'n dispersing flavor oils in the oral composition is preferably soybean lecithin, a natural emulsifier, having an approximate HL3 of 7 and a chemical formula:
C~I20COR
r~oCOR
CH2~-P~ -OCH2cH2N (CH3)3 R: Hydrogen or alkyl group The amount of lecithin referred to above in the oral composition is suitably from about 0.01% to about 5.00% by weight of the said oral composition, preferably, from about 0.10% to about 2.00%. --Other ingredients commonly used in typicaldentifrice compositions may include, but are not limited to, water, humectants, sweeteners, colors, opacifiers, abrasives, preservatives, thickeners and pharmacologically active ingredients such as water soluble fluoride, plaque and calculus inhibitors, antimicrobial agents, and dasensitizin~ compounds.
The sources of fluoride ions are well known in the art as anticaries agents. They are inorganic fluoride salts, such as sodium fluoride, stannous fluoride, sodium monofluorophosphate and the mixtures thereof. The amount of fluoride compounds, generally is from about 0.005% to about 3.00%, which releases from about 50 to about 3000 ppm of fluoride ion by weight of the oral composition.
2~71~
The liquid vehicle of the dentifrice pastes or gels may comprise water, humectants and thickening agents, in the amount from about 20.0% to about 90.0 by weight of the said composition. Examples of the suitable humectants are glycerine, sorbitol, yropylene glycol, polyethylene glycol and the mixtures thereof.
Examples of suitable thickening agents are modified cellulose products such as sodium carboxymethyl cellulose, hydroxyethyl cellulose, methyl cellulose, etc., and inorganic gel forming ingredients such as silica precipitates, colloidal magnesium aluminum carrageenan, alginates, etc. also are useful thickening agents.
The amount of the abrasive or polishiny agents in dentifrices is generally from about 15.0% to about 9~.0% by weight of the oral composition, preferably from about 15.0~ to about 80.0% in paste and gel and from about 65.0% to about 98.0% in toothpowder.
Examples of these materials are water-insoluble sodium metaphosphate, potassium metaphosphate, disbasic calcium phosphate anhydrous, dibasic calcium phosphate dihydrate, calcium carbonate, hydrated alumina, etc.
In clear gels, the preferred abrasive agents are colloidal silica and alkali metal alumino-silicate since they have refractive indices close to the refractive indices of the liquid gelling agents.
Typical flavor oils suitable for this invention include peppermint, spearmint, cinnamon, anethole, vanilla, lemon, orange and the like, at the levels from about 0.01% to about 1.0%. I~ is the particular feature of the invention that the flavor oil level for this mild tasting oral composition is 2 ~
significantly lower than the flavor levels in other typical oral c- ,~citions containing sodium lauryl sulfate.
In order to achieve cosmetically acceptable dentifrices gels and pastes, it is also useful to incorporate a colorant and a preservative.
The following examples further describe and provide preferred embodiments within the teachings of the invention and are solely for the purpose of illustration and are not to be considered as limitation of this invention.
EXAMPLES I - III
The following are dental gels of the present invention.
Weight (%) In~redient I II III
Water 12~5112.51 13.41 Glycerine 10.0010.00 10.00 Sorbitol (70%) 43.0043.00 43.00 Sodium carboxymethyl 0.90 0.90 0.90 celulose Sodium fluoride 0.24 0.24 0.24 Hydrated silica 30.0030.00 30.00 Potassium coco-hydrolyzed1.50 collagen (40%) Triethanolamine coco- 1.50 hydrolyzed collagen (40%) Collagen peptide 0.80 Disodium oleamido 0.20 PEG-2 sulfosuccinate Disodium cocoamido 0.20 MIPA sulfosuccinate Lecithin 0.40 0.40 0.40 Sodium saccharin 0.15 0.15 0.15 Methyl paraben 0.20 0.20 0.20 Dye solution (1.0%) 0.70 0.70 0.70 Flavor 0.20 0.20 0.20 2~7~
~XAMPLES IV - VI
The following are toothpastes representa-tive of the present invention.
Weight (%) Inqredient IV V VI
Water 24.85 24.90 24.85 Glycerine 16.00 16.00 16.00 Sorbitol (70%) 16.00 16.00 16.00 Natrosol 1.35 1.30 1.30 Sodium monofluorophosphate 0.80 0.80 0.80 Dicalcium phosphate anhydrous 7.00 7.00 7.00 Dicalcium phosphate 30.00 30.00 30.00 dihydrate 30.00 30.00 30.00 Aerosil 0.70 0.70 0.70 Potassium coco-hydrolyzed1.50 1.50 collayen (40%) Triethanolamine coco- 1.50 collagen peptide (40%) Disodium lauryl sulfo- 0.20 succinate Disodium oleamido 0.20 PEG-2 sulfosuccinate Disodium cocoamido 0.20 MIPA sulfosuccinate Lecithin 0.40 0.40 0.50 Sodium saccharin 0.20 0.20 0.15 Methyl paraben 0.20 0.20 0.20 Dye solution (1.0%) 0.60 0.60 0.60 Flavor 0.20 0.20 0.20 EXAMPLES VII- VIII
The following are toothpowders o~ the present invention.
Weight (~) Inqredient VII VIII
Sodium monofluorophosphate 0.80 0.80 Collagen peptide 1.00 0.80 Disodium lauryl sulfosuccinate 0.20 Hydrated silica 64.00 64.00 Dicalcium phosphate dihydrate 33.70 Calcium carbonate 33.65 Methyl paraben 0.15 0.15 Sodium saccharin 0.15 0.20 Flavor 0.20 0.20 ~7~
EXAMP~2S IX - X
The following are mouthrinses of the present invention.
Weight (%~
Inqredient IX X
Ethyl alcohol 5.00 7.00 Flavor 0.10 0.10 Glycerine 18.00 15.00 Potassium coco-hydrolyzed collagen0.50 Triethanolamine coca-hydrolyzed collagen 0.70 Lecithin 0.10 0.10 Sodium fluoride 0.02 0.02 Dye solution (1.0%) 0.10 0.10 Sodium benzoate 0.10 0.10 Water 76.03 76.88 EXAMPLES XI ~ XII
The ~ollowing are further e~amples of toothpastes of the present invention.
Weight (%) Inqredient XI XII
Water, deionized 27.89 to 27.49 42.59 to 43.09 Sodium fluoride 0.24 0.24 Methylparaben 0.12 0.12 Propylparaben 0.05 0.05 Sodium saccharin 0.30 0.20 Titanium dioxide 1.00 1.00 Polyoxyethylene (40) 2.00 2.00 stearate Fumed silica 0.60 1.20 Sorbitol 70% aqueous 12.00 12.00 solution Amorphous silica gel 26.00 14.00 Glycerin 25.00 10.00 Guar gum 0.40 0.40 Sodium carboxymethyl- 1.40 1.70 cellulose Potassium Coco- 2.00 1.50 hydrolyzed animal protein Flavor 0.60 to 1.00 0.2 to 0.7 Lecithin powder 0.30 0.30 Disodium lauryl 0.10 sulfosuccinate While certain representative embodiments and details have been shown for the pu~ose of illustrating the invention, it will be apparent to those skilled in the art that various changes may be made therein without departing from the spirit or scope of the invention.
Claims (10)
1. An oral hygiene composition which is free of sodium lauryl sulfate comprising:
a protein derivative selected from the group consisting of protein fatty acid condensates and acid hydrolyzed animal proteins, together with at least one member of the group of (a) a flavor oil with a high foaming sulfosuccinate, and (b) a natural emulsifier, wherein the protein derivative is present in an amount of about 0.01 to about 4.00% by weight, the high foaming sulfosuccinate is present in an amount of about 0.01 to about 1.50% by weight, the natural emulsifier is present in an amount of about 0.01 to about 5.00% by weight, and the flavor oil is present in an amount of about 0.01 to about 1.0% by weight.
a protein derivative selected from the group consisting of protein fatty acid condensates and acid hydrolyzed animal proteins, together with at least one member of the group of (a) a flavor oil with a high foaming sulfosuccinate, and (b) a natural emulsifier, wherein the protein derivative is present in an amount of about 0.01 to about 4.00% by weight, the high foaming sulfosuccinate is present in an amount of about 0.01 to about 1.50% by weight, the natural emulsifier is present in an amount of about 0.01 to about 5.00% by weight, and the flavor oil is present in an amount of about 0.01 to about 1.0% by weight.
2. An oral hygiene composition according to claim 1 which further contains from about 0.005% to about 3.00% by weight of a fluoride anticaries agent.
3. An oral hygiene composition according to claim 2, said composition being in the form of a toothpowder, wherein said protein derivative is collagen peptide and wherein said high foaming sulfosuccinate is disodium lauryl sulfosuccinate.
4. An oral hygiene composition according to claim 1 which contains both (a) and (b).
5. An oral hygiene composition according to claim 4 wherein said protein derivative is present in an amount of about 0.01 to 4.00% by weight, said high foaming sulfosuccinate is present in an amount of about 0.01 to 1.50% by weight, said natural emulsifier is lecithin, said lecithin being present in an amount of about 0.01 to 5.00% by weight, and said flavor oil is present in an amount of about 0.01% to 1.0% by weight and which further contains from about 0.005% to about 3.00%
by weight of a fluoride anticaries agent.
by weight of a fluoride anticaries agent.
6. An oral hygiene composition according to claim 4, said composition being in the form of toothpaste or a dental gel, wherein said protein derivative is a member of the group consisting of potassium coco-hydrolyzed collagen, triethanolamine coco-hydrolyzed collagen, potassium coco-hydrolyzed animal protein and collagen peptide and gel, wherein said high foaming sulfosuccinate is selected from the group consisting of disodium oleamido PEG-2 sulfosuccinate and disodium cocoamido MIPA sulfosuccinate and wherein said natural emulsifier is lecithin.
7. An oral hygiene composition according to claim 1 in which the member of the group is (b) and wherein said protein derivative is present in an amount of about 0.01 to about 4.00% by weight, said natural emulsifier is lecithin, said lecithin being present in an amount of about 0.01 to about 5.00% by weight, the composition further containing from about 0.005 to about 3.00% by weight of a fluoride anticaries agent.
8. An oral hygiene composition according to claim 7 in the form of a toothpaste wherein said protein derivative is potassium coco-hydrolyzed animal protein and also comprising polyoxyethylene (40) stearate.
9. An oral hygiene composition according to claim 8 containing also a flavor oil in an amount of about 0.01 to 1.0% by weight.
10. An oral hygiene composition according to claim 9 in the form of a mouthrinse, wherein said protein derivative is selected from the group consisting of potassium coco-hydrolyzed collagen and triethanolamine coco-hydrolyzed collagen.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/713,512 US5120528A (en) | 1991-06-12 | 1991-06-12 | Taste preserving, mild oral hygiene compositions |
| US07/713,512 | 1991-06-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2071146A1 CA2071146A1 (en) | 1992-12-13 |
| CA2071146C true CA2071146C (en) | 1999-06-08 |
Family
ID=24866431
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002071146A Expired - Lifetime CA2071146C (en) | 1991-06-12 | 1992-06-12 | Taste preserving, mild oral hygiene compositions |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5120528A (en) |
| EP (1) | EP0518608B1 (en) |
| JP (1) | JP2922362B2 (en) |
| KR (1) | KR0169139B1 (en) |
| CN (1) | CN1043185C (en) |
| AT (1) | ATE119765T1 (en) |
| CA (1) | CA2071146C (en) |
| DE (1) | DE69201677T2 (en) |
| DK (1) | DK0518608T3 (en) |
| ES (1) | ES2069380T3 (en) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120528A (en) * | 1991-06-12 | 1992-06-09 | Block Drug Company, Inc. | Taste preserving, mild oral hygiene compositions |
| EP0635218B1 (en) * | 1993-02-05 | 2000-10-25 | Kao Corporation | Taste modifying method and bitter taste reducing method |
| US5785984A (en) * | 1993-02-05 | 1998-07-28 | Kao Corporation | Taste-modifying method and bitterness-decreasing method |
| US5296215A (en) * | 1993-06-16 | 1994-03-22 | Colgate-Palmolive Company | High foaming rheologically stable non-irritating oral composition |
| US5547657A (en) * | 1994-10-11 | 1996-08-20 | Eastman Chemical Company | Low-irritation anesthetic and antiseptic mouth rinse |
| US5670137A (en) * | 1994-12-12 | 1997-09-23 | L'oreal | Anhydrous dentifrice composition |
| JP4106087B2 (en) * | 1995-06-30 | 2008-06-25 | イネオス シリカス リミテッド | Amorphous silica and composition for oral cavity |
| JP4144995B2 (en) * | 2000-02-17 | 2008-09-03 | ライオン株式会社 | Oral composition |
| US20030072717A1 (en) | 2001-02-23 | 2003-04-17 | Vapotronics, Inc. | Inhalation device having an optimized air flow path |
| CA2448022C (en) * | 2001-05-21 | 2013-11-12 | Injet Digital Aerosols Limited | Compositions for protein delivery via the pulmonary route |
| EP1410789B1 (en) * | 2001-07-05 | 2011-09-21 | Sunstar Inc. | Oral preparation |
| US7632525B2 (en) * | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
| EP2020221B1 (en) * | 2007-06-19 | 2012-02-29 | Neubourg Skin Care GmbH & Co. KG | DMS (Derma Membrane Structure) in foaming creams |
| KR100935211B1 (en) | 2008-12-30 | 2010-01-06 | 남지원 | Composition of toothpowder-paste containing wheat-flour and bamboo-salt, and manufacturing method thereof |
| RU2455975C2 (en) * | 2010-10-19 | 2012-07-20 | Олег Анатольевич Бобров | Toothpaste |
| WO2014000982A1 (en) * | 2012-06-26 | 2014-01-03 | Unilever Plc | Oral care compositions |
| KR101526258B1 (en) * | 2012-12-05 | 2015-06-10 | 선바이오(주) | Mouthwashes and pharmaceutical compositions comprising polyethylene glycol derivatives for preventing, treating, improving xerostomia |
| JPWO2017085927A1 (en) * | 2015-11-18 | 2018-08-30 | 株式会社サンギ | Oral composition |
| WO2018135791A1 (en) * | 2017-01-23 | 2018-07-26 | 주식회사 엘지생활건강 | Pump-type toothpaste composition |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3897548A (en) * | 1973-04-09 | 1975-07-29 | Indiana University Foundation | Oral compositions for retarding the formation of dental plaque and methods of utilization thereof |
| US3942512A (en) * | 1973-05-22 | 1976-03-09 | Hargett Edgar R | Pharyngeal and nasopharyngeal treatment |
| US3873721A (en) * | 1973-05-22 | 1975-03-25 | Edgar R Hargett | Pharyngeal and nasopharyngeal treatment |
| US3971852A (en) * | 1973-06-12 | 1976-07-27 | Polak's Frutal Works, Inc. | Process of encapsulating an oil and product produced thereby |
| US4115313A (en) * | 1974-10-08 | 1978-09-19 | Irving Lyon | Bile acid emulsions |
| US3975514A (en) * | 1975-01-13 | 1976-08-17 | Geraldine Fay Weisz | Fluoride mouth wash compositions |
| DE2712228A1 (en) * | 1977-03-19 | 1978-09-28 | Georg Dr Leiderer | Protein hydrolysate from collagen by strong acid hydrolysis - useful as additive for tooth-pastes, textile and hair washing compsns. |
| US4156715A (en) * | 1977-11-28 | 1979-05-29 | General Mills, Inc. | Plaque inhibiting composition and method |
| US4376781A (en) * | 1978-02-27 | 1983-03-15 | Inverni Della Beffa S.P.A. | Pharmaceutical compositions |
| US4269822A (en) * | 1979-07-20 | 1981-05-26 | Laclede Professional Products, Inc. | Antiseptic dentifrice |
| US4428930A (en) * | 1981-09-18 | 1984-01-31 | Minnesota Mining And Manufacturing Company | Compositions and method for reducing elution of therapeutic agents from teeth |
| US4470964A (en) * | 1981-09-18 | 1984-09-11 | Minnesota Minning And Manufacturing Company | Composition and method for reducing elution of therapeutic agents from teeth |
| US4391798A (en) * | 1982-03-15 | 1983-07-05 | Colgate-Palmolive Company | Non-irritating dentifrice |
| US4419346A (en) * | 1982-08-13 | 1983-12-06 | Nabisco Brands, Inc. | Method and composition to inhibit the growth of Streptococcus mutans by the use of saccharin/fluoride combination |
| US4950479A (en) * | 1986-11-06 | 1990-08-21 | Hill Ira D | Method of interrupting the formation of plaque |
| DE3417235A1 (en) * | 1983-12-15 | 1985-06-27 | Rudolf V. Dr.rer.nat Dipl.-Chem. 5024 Pulheim Noronha | Dental care composition containing phosphatides |
| US4725576A (en) * | 1983-12-29 | 1988-02-16 | Research Foundation Of State University Of New York | Fungicidal polypeptide compositions containing L-histidine and methods for use therefore |
| SE8502540L (en) * | 1984-06-12 | 1985-12-13 | Colgate Palmolive Co | STABLE DENTALS CONTAINING DEXTRANAS |
| CA1245988A (en) * | 1984-11-02 | 1988-12-06 | Richard H. Roydhouse | Oral fine dispersion sprays and emulsions |
| CA1283864C (en) * | 1986-08-11 | 1991-05-07 | Richard H. Roydhouse | Body lubricating and cleansing fluid |
| DE3627296A1 (en) * | 1986-08-12 | 1988-02-18 | Unilever Nv | Oral hygiene compositions |
| LU86587A1 (en) * | 1986-09-15 | 1988-04-05 | Oreal | TOOTHPASTE CONTAINING A POLY NON-IONIC SURFACTANT (HYDROXYPROPYLETHER) AND A SALT OF A SPECIFIC DERIVATIVE OF A PROTEIN DEGRADATION PRODUCT |
| US4863900A (en) * | 1987-01-15 | 1989-09-05 | The Research Foundation Of State University Of New York | Method for reducing viral transmission with poly-L-histidine |
| US4835002A (en) * | 1987-07-10 | 1989-05-30 | Wolf Peter A | Microemulsions of oil in water and alcohol |
| US4868287A (en) * | 1987-08-24 | 1989-09-19 | University Of South Alabama | Inhibition of mineral deposition by polyanionic/hydrophobic peptides and derivatives thereof having a clustered block copolymer structure |
| US4942034A (en) * | 1988-11-14 | 1990-07-17 | Hill Ira D | Dental stimulator |
| US4983404A (en) * | 1989-06-05 | 1991-01-08 | Warner-Lambert Company | Controlled release flavor system and method of preparation |
| US5120528A (en) * | 1991-06-12 | 1992-06-09 | Block Drug Company, Inc. | Taste preserving, mild oral hygiene compositions |
-
1991
- 1991-06-12 US US07/713,512 patent/US5120528A/en not_active Expired - Lifetime
-
1992
- 1992-06-01 CN CN92104305A patent/CN1043185C/en not_active Expired - Lifetime
- 1992-06-09 ES ES92305264T patent/ES2069380T3/en not_active Expired - Lifetime
- 1992-06-09 AT AT92305264T patent/ATE119765T1/en active
- 1992-06-09 DK DK92305264.1T patent/DK0518608T3/en active
- 1992-06-09 EP EP92305264A patent/EP0518608B1/en not_active Expired - Lifetime
- 1992-06-09 DE DE69201677T patent/DE69201677T2/en not_active Expired - Lifetime
- 1992-06-11 KR KR1019920010152A patent/KR0169139B1/en not_active IP Right Cessation
- 1992-06-12 JP JP4153271A patent/JP2922362B2/en not_active Expired - Lifetime
- 1992-06-12 CA CA002071146A patent/CA2071146C/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DK0518608T3 (en) | 1995-05-29 |
| US5120528A (en) | 1992-06-09 |
| CA2071146A1 (en) | 1992-12-13 |
| KR0169139B1 (en) | 1999-01-15 |
| CN1043185C (en) | 1999-05-05 |
| ES2069380T3 (en) | 1995-05-01 |
| EP0518608B1 (en) | 1995-03-15 |
| EP0518608A1 (en) | 1992-12-16 |
| JPH05170632A (en) | 1993-07-09 |
| JP2922362B2 (en) | 1999-07-19 |
| KR930000103A (en) | 1993-01-15 |
| AU648173B2 (en) | 1994-04-14 |
| AU1730892A (en) | 1992-12-17 |
| ATE119765T1 (en) | 1995-04-15 |
| DE69201677D1 (en) | 1995-04-20 |
| CN1067576A (en) | 1993-01-06 |
| DE69201677T2 (en) | 1995-07-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2071146C (en) | Taste preserving, mild oral hygiene compositions | |
| US5833952A (en) | Oral compositions | |
| CA1149747A (en) | Toothpaste comprising a copper compound and a silica polishing agent useful for the prevention of the formation of dental plaque | |
| US4980153A (en) | Antiplaque oral hygiene composition | |
| US4130636A (en) | Dentifrice | |
| US4902498A (en) | Oral compositions | |
| US4490353A (en) | Antiplaque dentifrice with improved fluoride stability | |
| US3932606A (en) | Dentifrice | |
| IE62164B1 (en) | Oral compositions | |
| GB2188548A (en) | Oral hygiene compositions | |
| US4528182A (en) | Stable antiplaque dentifrice with improved foaming | |
| US4666517A (en) | Antiplaque oral composition | |
| US5376360A (en) | Baking soda toothpaste containing soluble pyrophosphate salts | |
| CA2162663A1 (en) | Oral compositions | |
| EA001791B1 (en) | Dentrifice composition | |
| US4774078A (en) | Stable antiplaque dentifrice based on hexetidine, zinc ion and fluoride | |
| US3624199A (en) | Dental cream | |
| US4256730A (en) | Oral compositions | |
| US4356168A (en) | Opacified dental cream containing a binary fluorine-providing system | |
| US4425324A (en) | Hazed toothpaste | |
| EP1052966B1 (en) | Oral care compositions | |
| CA1164802A (en) | Silica with binary fluoride system as opaque dental cream | |
| NZ208730A (en) | Dentifrice containing antiplaque quaternary ammonium compound | |
| GB2048668A (en) | Periodontal preparations containing folic acid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20120612 |