CA2075624A1 - Ultrasound-Enhanced Delivery of Materials Through the Skin - Google Patents

Ultrasound-Enhanced Delivery of Materials Through the Skin

Info

Publication number
CA2075624A1
CA2075624A1 CA2075624A CA2075624A CA2075624A1 CA 2075624 A1 CA2075624 A1 CA 2075624A1 CA 2075624 A CA2075624 A CA 2075624A CA 2075624 A CA2075624 A CA 2075624A CA 2075624 A1 CA2075624 A1 CA 2075624A1
Authority
CA
Canada
Prior art keywords
ultrasound
skin
materials
enhanced delivery
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2075624A
Other languages
French (fr)
Other versions
CA2075624C (en
Inventor
Durairaj Bommannan
Hiroshia Okuyama
Richard Henry Guy
Paul Stauffer
Gordon L. Flynn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Cygnus Inc
Original Assignee
Durairaj Bommannan
Hiroshia Okuyama
Richard Henry Guy
Paul Stauffer
Gordon L. Flynn
Cygnus Therapeutic Systems
The Regents Of The University Of California
Cygnus, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Durairaj Bommannan, Hiroshia Okuyama, Richard Henry Guy, Paul Stauffer, Gordon L. Flynn, Cygnus Therapeutic Systems, The Regents Of The University Of California, Cygnus, Inc. filed Critical Durairaj Bommannan
Priority to CA002196746A priority Critical patent/CA2196746A1/en
Publication of CA2075624A1 publication Critical patent/CA2075624A1/en
Application granted granted Critical
Publication of CA2075624C publication Critical patent/CA2075624C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A61N7/02—Localised ultrasound hyperthermia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N7/00—Ultrasound therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0045—Devices for taking samples of body liquids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/02—Instruments for taking cell samples or for biopsy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

Abstract

An in vitro method of diagnosis wherein a physiologic sample is assayed, the sample having been obtained at the skin surface by passage through the stratum corneum which has decreased barrier function as a result of exposure to ultrasound at a frequency of above about 10 MHz.
CA002075624A 1990-02-23 1991-02-21 Ultrasound-enhanced delivery of materials through the skin Expired - Fee Related CA2075624C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002196746A CA2196746A1 (en) 1990-02-23 1991-02-21 Ultrasound-enhanced delivery of materials through the skin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US484,560 1983-04-13
US07/484,560 US5115805A (en) 1990-02-23 1990-02-23 Ultrasound-enhanced delivery of materials into and through the skin

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA002196746A Division CA2196746A1 (en) 1990-02-23 1991-02-21 Ultrasound-enhanced delivery of materials through the skin

Publications (2)

Publication Number Publication Date
CA2075624A1 true CA2075624A1 (en) 1991-08-24
CA2075624C CA2075624C (en) 1997-11-18

Family

ID=23924657

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002075624A Expired - Fee Related CA2075624C (en) 1990-02-23 1991-02-21 Ultrasound-enhanced delivery of materials through the skin

Country Status (15)

Country Link
US (3) US5115805A (en)
EP (2) EP0736305B1 (en)
JP (1) JP2695986B2 (en)
AT (2) ATE192344T1 (en)
AU (1) AU656519B2 (en)
CA (1) CA2075624C (en)
DE (2) DE69124365T2 (en)
DK (1) DK0736305T3 (en)
ES (2) ES2097206T3 (en)
FI (1) FI923743A0 (en)
GR (1) GR3034087T3 (en)
IE (1) IE910613A1 (en)
NZ (1) NZ237197A (en)
PT (1) PT96856A (en)
WO (1) WO1991012772A1 (en)

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ATE192344T1 (en) 2000-05-15
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CA2075624C (en) 1997-11-18
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AU656519B2 (en) 1995-02-09
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EP0736305B1 (en) 2000-05-03
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PT96856A (en) 1991-11-29
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US5115805A (en) 1992-05-26
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DE69124365T2 (en) 1997-05-28
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ATE148001T1 (en) 1997-02-15
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US5323769A (en) 1994-06-28
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