CA2084519A1 - Method for treating alcoholism with nalmefene - Google Patents
Method for treating alcoholism with nalmefeneInfo
- Publication number
- CA2084519A1 CA2084519A1 CA 2084519 CA2084519A CA2084519A1 CA 2084519 A1 CA2084519 A1 CA 2084519A1 CA 2084519 CA2084519 CA 2084519 CA 2084519 A CA2084519 A CA 2084519A CA 2084519 A1 CA2084519 A1 CA 2084519A1
- Authority
- CA
- Canada
- Prior art keywords
- nalmefene
- treating alcoholism
- alcoholism
- treating
- alcoholdrinking
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
Abstract
A method for treating alcoholism. The alcoholdrinking response of alcoholics is extinguished by having them drink alcoholic beverages while nalmefene, an opiate antagonist, blocks the positive reinforcement effect of ethanol in the brain.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US532,424 | 1990-06-04 | ||
US07/532,424 US5086058A (en) | 1990-06-04 | 1990-06-04 | Method for treating alcoholism with nalmefene |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2084519A1 true CA2084519A1 (en) | 1991-12-05 |
CA2084519C CA2084519C (en) | 1999-02-09 |
Family
ID=24121726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002084519A Expired - Lifetime CA2084519C (en) | 1990-06-04 | 1991-05-10 | Method for treating alcoholism with nalmefene |
Country Status (19)
Country | Link |
---|---|
US (1) | US5086058A (en) |
EP (1) | EP0531415B1 (en) |
JP (1) | JP3059213B2 (en) |
AT (1) | ATE145329T1 (en) |
AU (1) | AU642748B2 (en) |
CA (1) | CA2084519C (en) |
DE (1) | DE69123247T2 (en) |
DK (1) | DK0531415T3 (en) |
ES (1) | ES2097209T3 (en) |
FI (1) | FI925513A (en) |
GR (1) | GR3022289T3 (en) |
HU (1) | HU210637B (en) |
IE (1) | IE77333B1 (en) |
LT (1) | LT3893B (en) |
LV (1) | LV10190B (en) |
NZ (1) | NZ238391A (en) |
RU (1) | RU2090190C1 (en) |
WO (1) | WO1991018605A1 (en) |
ZA (1) | ZA914185B (en) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4882335A (en) * | 1988-06-13 | 1989-11-21 | Alko Limited | Method for treating alcohol-drinking response |
US6271239B1 (en) * | 1992-04-13 | 2001-08-07 | Regents Of The University Of Minnesota | Delta opioid receptor-selective benzylidene-substituted morphinans |
US5352680A (en) * | 1992-07-15 | 1994-10-04 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists to block opioid agonist tolerance and dependence |
US6096756A (en) * | 1992-09-21 | 2000-08-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
US5580876A (en) * | 1992-09-21 | 1996-12-03 | Albert Einstein College Of Medicine Of Yeshiva University, A Division Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by morphine and other bimodally-acting opioid agonists |
USRE36547E (en) * | 1992-09-21 | 2000-02-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists |
US5298622A (en) * | 1993-05-12 | 1994-03-29 | Regents Of The University Of Minnesota | Spiroindane opiate analogs |
US5457208A (en) | 1993-06-21 | 1995-10-10 | Regents Of The University Of Minnesota | Kappa opioid receptor antagonists |
US5587381A (en) * | 1995-03-27 | 1996-12-24 | Sinclair; John D. | Method for terminating methadone maintenance through extinction of the opiate-taking responses |
WO1997018781A1 (en) * | 1995-11-20 | 1997-05-29 | University Of Miami | Method of treating nicotine dependence |
US5878750A (en) * | 1996-11-14 | 1999-03-09 | Clemens; Anton H. | Method of treating the syndrome of coronary heart disease risk factors in humans |
US5780479A (en) * | 1997-04-04 | 1998-07-14 | Regents Of The University Of Minnesota | Use of opioid antagonists to treat impulse-control disorders |
WO1999032119A1 (en) * | 1997-12-22 | 1999-07-01 | Euro-Celtique, S.A. | Opioid agonist/antagonist combinations |
UA53774C2 (en) * | 1997-12-22 | 2003-02-17 | Еро-Селтік, С.А. | Method of reducing abuse potential of an oral dosage form of opioid analgesic |
US6375957B1 (en) | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
CA2392510A1 (en) * | 1999-11-30 | 2001-06-07 | Corixa Corporation | Compositions and methods for therapy and diagnosis of breast cancer |
HU229705B1 (en) * | 2000-02-08 | 2014-05-28 | Euro Celtique Sa | Tamper-resistant oral opioid agonist formulations |
US6716449B2 (en) | 2000-02-08 | 2004-04-06 | Euro-Celtique S.A. | Controlled-release compositions containing opioid agonist and antagonist |
US20040024004A1 (en) * | 2001-05-04 | 2004-02-05 | Sherman Barry M. | Novel compositions and methods for enhancing potency or reducing adverse side effects of opioid agonists |
US6846831B2 (en) | 2000-08-15 | 2005-01-25 | Cpd, Llc | Method of treating the syndrome of lipodystrophy |
US6528520B2 (en) * | 2000-08-15 | 2003-03-04 | Cpd, Llc | Method of treating the syndrome of coronary heart disease risk factors in humans |
US6262062B1 (en) * | 2000-08-15 | 2001-07-17 | Cpd, Llc | Method of treating the syndrome of coronary heart disease risk factors in humans |
ATE493130T1 (en) | 2001-05-11 | 2011-01-15 | Endo Pharmaceuticals Inc | MEDICINAL FORM CONTAINING OPIOID AGAINST ABUSE |
EP1411352B1 (en) * | 2001-07-13 | 2012-01-11 | ARKRAY, Inc. | Analysing instrument and lancet-integrated attachment for concentration measuring device |
DE60230632D1 (en) * | 2001-07-18 | 2009-02-12 | Euro Celtique Sa | PHARMACEUTICAL COMBINATIONS OF OXYCODONE AND NALOXONE |
WO2003013433A2 (en) * | 2001-08-06 | 2003-02-20 | Euro-Celtique S.A. | Sequestered antagonist formulations |
ATE431738T1 (en) | 2001-08-06 | 2009-06-15 | Euro Celtique Sa | OPIOID AGONIST FORMULATIONS WITH RELEASABLE AND SEQUESTRED ANTAGONIST |
US20030044458A1 (en) | 2001-08-06 | 2003-03-06 | Curtis Wright | Oral dosage form comprising a therapeutic agent and an adverse-effect agent |
JP2005508888A (en) * | 2001-08-14 | 2005-04-07 | バイオティ セラピーズ コーポレイション | How to treat alcoholism or alcoholism |
EP2243471A1 (en) | 2002-04-05 | 2010-10-27 | Euro-Celtique S.A. | Matrix for sustained, invariant and independent release of active compounds |
US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
US7923454B2 (en) * | 2002-05-17 | 2011-04-12 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
US7736665B2 (en) * | 2002-05-31 | 2010-06-15 | Titan Pharmaceuticals, Inc. | Implantable polymeric device for sustained release of buprenorphine |
DK1551372T3 (en) * | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | SEQUERATION SUBSTANCES AND RELATED COMPOSITIONS AND PROCEDURES |
NZ542548A (en) | 2003-03-31 | 2009-04-30 | Titan Pharmaceuticals Inc | Implantable polymeric device for sustained release of dopamine agonist |
US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
US20050038062A1 (en) * | 2003-04-14 | 2005-02-17 | Burns Lindsay H. | Methods and materials for the treatment of pain comprising opioid antagonists |
TWI347201B (en) * | 2003-04-21 | 2011-08-21 | Euro Celtique Sa | Pharmaceutical products,uses thereof and methods for preparing the same |
US8017622B2 (en) * | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
US20060009478A1 (en) * | 2003-10-15 | 2006-01-12 | Nadav Friedmann | Methods for the treatment of back pain |
EP1604666A1 (en) * | 2004-06-08 | 2005-12-14 | Euro-Celtique S.A. | Opioids for the treatment of the Chronic Obstructive Pulmonary Disease (COPD) |
EP1702558A1 (en) * | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Method and device for the assessment of bowel function |
CN101677963B (en) | 2006-06-19 | 2012-05-30 | 奥尔制药公司 | Pharmaceutical compositions |
CA2666846C (en) | 2006-10-20 | 2018-04-10 | Cpd, Llc | Method of restoring the incretin effect |
US8623418B2 (en) * | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
AU2008346870A1 (en) * | 2007-12-17 | 2009-07-16 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
US20100151014A1 (en) * | 2008-12-16 | 2010-06-17 | Alpharma Pharmaceuticals, Llc | Pharmaceutical composition |
DK2291380T3 (en) * | 2008-04-24 | 2011-12-05 | Janssen Pharmaceutica Nv | Nalmefene prodrugs |
KR101598138B1 (en) * | 2008-04-24 | 2016-02-29 | 얀센 파마슈티카 엔.브이. | Nalmefene di-ester prodrugs |
BRPI0910780A2 (en) * | 2008-07-07 | 2016-08-09 | Euro Celtique Sa | use of opioid antagonists for the treatment of urinary retention |
DK2405915T3 (en) | 2009-03-10 | 2019-02-11 | Euro Celtique Sa | PHARMACEUTICAL COMPOSITIONS WITH IMMEDIATE RELEASE INCLUDING OXYCODON AND NALOXON |
US20140005216A1 (en) | 2012-06-27 | 2014-01-02 | H. Lundbeck A/S | Nalmefene for reduction of alcohol consumption in specific target populations |
WO2014170353A1 (en) * | 2013-04-17 | 2014-10-23 | H. Lundbeck A/S | Nalmefene for treatment of patients with sleep disorder |
KR20180037074A (en) | 2013-07-23 | 2018-04-10 | 유로-셀티큐 에스.에이. | A combination of oxycodone and naloxone for use in treating pain in patients suffering from pain and a disease resulting in intestinal dysbiosis and/or increasing the risk for intestinal bacterial translocation |
US20170042887A1 (en) * | 2014-04-22 | 2017-02-16 | Otsuka Pharmaceutical. Co., Ltd. | Combination of Brexpiprazole and Nalmefene and Use Thereof for Treating Substance-Related Disorders |
ES2787223T3 (en) | 2014-11-07 | 2020-10-15 | Univ Minnesota | Salts and compositions useful for treating diseases |
BR112018071705A2 (en) * | 2016-04-22 | 2019-02-19 | Taiwanj Pharmaceuticals Co., Ltd. | prophylaxis method or treatment of nafld, nash or ash, use of a compound of formula (i), and compound of formula (i) |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4882335A (en) * | 1988-06-13 | 1989-11-21 | Alko Limited | Method for treating alcohol-drinking response |
US4857533A (en) * | 1988-12-15 | 1989-08-15 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for autoimmune diseases |
US4863928A (en) * | 1989-01-04 | 1989-09-05 | Baker Cummins Pharmaceuticals, Inc. | Method of treatment for arthritic and inflammatory diseases |
US5096715A (en) * | 1989-11-20 | 1992-03-17 | Alko Ltd. | Method and means for treating alcoholism by extinguishing the alcohol-drinking response using a transdermally administered opiate antagonist |
-
1990
- 1990-06-04 US US07/532,424 patent/US5086058A/en not_active Expired - Lifetime
-
1991
- 1991-05-10 AU AU79740/91A patent/AU642748B2/en not_active Expired
- 1991-05-10 HU HU9203835A patent/HU210637B/en unknown
- 1991-05-10 CA CA002084519A patent/CA2084519C/en not_active Expired - Lifetime
- 1991-05-10 EP EP91910595A patent/EP0531415B1/en not_active Expired - Lifetime
- 1991-05-10 DE DE69123247T patent/DE69123247T2/en not_active Expired - Lifetime
- 1991-05-10 JP JP3509984A patent/JP3059213B2/en not_active Expired - Lifetime
- 1991-05-10 AT AT91910595T patent/ATE145329T1/en not_active IP Right Cessation
- 1991-05-10 ES ES91910595T patent/ES2097209T3/en not_active Expired - Lifetime
- 1991-05-10 RU RU9192016403A patent/RU2090190C1/en active
- 1991-05-10 DK DK91910595.7T patent/DK0531415T3/en active
- 1991-05-10 WO PCT/US1991/003241 patent/WO1991018605A1/en active IP Right Grant
- 1991-06-03 ZA ZA914185A patent/ZA914185B/en unknown
- 1991-06-04 IE IE188891A patent/IE77333B1/en not_active IP Right Cessation
- 1991-06-04 NZ NZ238391A patent/NZ238391A/en not_active IP Right Cessation
-
1992
- 1992-12-04 FI FI925513A patent/FI925513A/en unknown
-
1993
- 1993-08-31 LV LVP-93-1052A patent/LV10190B/en unknown
- 1993-11-25 LT LTIP1486A patent/LT3893B/en not_active IP Right Cessation
-
1997
- 1997-01-16 GR GR960403307T patent/GR3022289T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE69123247D1 (en) | 1997-01-02 |
HUT65523A (en) | 1994-06-28 |
ATE145329T1 (en) | 1996-12-15 |
DK0531415T3 (en) | 1996-12-09 |
JP3059213B2 (en) | 2000-07-04 |
EP0531415A1 (en) | 1993-03-17 |
AU7974091A (en) | 1991-12-31 |
RU2090190C1 (en) | 1997-09-20 |
IE77333B1 (en) | 1997-12-03 |
ZA914185B (en) | 1992-07-29 |
FI925513A0 (en) | 1992-12-04 |
CA2084519C (en) | 1999-02-09 |
US5086058A (en) | 1992-02-04 |
IE911888A1 (en) | 1991-12-04 |
ES2097209T3 (en) | 1997-04-01 |
AU642748B2 (en) | 1993-10-28 |
FI925513A (en) | 1992-12-04 |
DE69123247T2 (en) | 1998-01-15 |
LV10190B (en) | 1995-06-20 |
JPH06506665A (en) | 1994-07-28 |
LT3893B (en) | 1996-04-25 |
LTIP1486A (en) | 1995-09-25 |
EP0531415B1 (en) | 1996-11-20 |
HU9203835D0 (en) | 1993-03-29 |
HU210637B (en) | 1995-06-28 |
GR3022289T3 (en) | 1997-04-30 |
LV10190A (en) | 1994-10-20 |
NZ238391A (en) | 1997-06-24 |
WO1991018605A1 (en) | 1991-12-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |