CA2092045A1 - Erythromycin derivatives, preparation and use thereof - Google Patents
Erythromycin derivatives, preparation and use thereofInfo
- Publication number
- CA2092045A1 CA2092045A1 CA002092045A CA2092045A CA2092045A1 CA 2092045 A1 CA2092045 A1 CA 2092045A1 CA 002092045 A CA002092045 A CA 002092045A CA 2092045 A CA2092045 A CA 2092045A CA 2092045 A1 CA2092045 A1 CA 2092045A1
- Authority
- CA
- Canada
- Prior art keywords
- hemiacetal
- salt
- erythromycin derivative
- positions
- hydroxyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Abstract
Disclosed are (1) a structurally novel 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP6424392 | 1992-03-19 | ||
JP64243/1992 | 1992-03-19 | ||
JP152467/1992 | 1992-06-11 | ||
JP15246792 | 1992-06-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2092045A1 true CA2092045A1 (en) | 1993-09-20 |
CA2092045C CA2092045C (en) | 2004-08-10 |
Family
ID=26405362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002092045A Expired - Fee Related CA2092045C (en) | 1992-03-19 | 1993-03-19 | Erythromycin derivatives, preparation and use thereof |
Country Status (5)
Country | Link |
---|---|
US (2) | US5470961A (en) |
EP (1) | EP0561413B1 (en) |
AT (1) | ATE138925T1 (en) |
CA (1) | CA2092045C (en) |
DE (1) | DE69302938T2 (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE138925T1 (en) * | 1992-03-19 | 1996-06-15 | Takeda Chemical Industries Ltd | ERYTHROMYCIN DERIVATIVES, PRODUCTION AND USE THEREOF |
US6077943A (en) * | 1996-03-01 | 2000-06-20 | Takeda Chemical Industries, Ltd. | Method of producing erythromycin derivative |
CA2399198A1 (en) | 2000-02-18 | 2001-08-23 | Christopher Carreras | Motilide compounds |
CA2437576A1 (en) | 2001-02-15 | 2002-08-22 | Kosan Biosciences, Inc. | Method for evaluating therapeutic efficacy |
WO2004111077A1 (en) | 2003-06-18 | 2004-12-23 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor |
US20050113319A1 (en) * | 2003-08-26 | 2005-05-26 | Christopher Carreras | 11-Deoxy-6,9-ether erythromycin compounds |
US7407941B2 (en) * | 2003-08-26 | 2008-08-05 | Pfizer, Inc. | N-desmethyl-N-substituted-11-deoxyerythromycin compounds |
US7211568B2 (en) * | 2003-12-18 | 2007-05-01 | Kosan Biosciences Incorporated | 9-Desoxoerythromycin compounds as prokinetic agents |
US7582611B2 (en) | 2005-05-24 | 2009-09-01 | Pfizer Inc. | Motilide compounds |
EP1960414A4 (en) * | 2005-12-08 | 2008-12-17 | Pfizer | Method for demethylating the 3'-dimethylamino group of erythromycin compounds |
JP5684474B2 (en) | 2006-09-11 | 2015-03-11 | オセラ セラピューティクス, インコーポレイテッド | Macrocyclic antagonist of motilin receptor for the treatment of gastrointestinal dysmotility disease |
ES2401467T3 (en) | 2006-12-05 | 2013-04-19 | Bristol-Myers Squibb Company | Motilide polymorphs |
US20080287371A1 (en) * | 2007-05-17 | 2008-11-20 | Tranzyme Pharma Inc. | Macrocyclic antagonists of the motilin receptor for modulation of the migrating motor complex |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2926959A1 (en) * | 1979-07-04 | 1981-01-22 | Hoechst Ag | DEVICE FOR LIQUID-LIQUID EXTRACTION |
US5008249A (en) * | 1985-08-31 | 1991-04-16 | Kitasato Kenkyusho | Therapeutic method of stimulating digestive tract contractile motion in mammals |
DE3689758T2 (en) * | 1985-08-31 | 1994-08-18 | Kitasato Inst | Erythromycin derivative and process for its preparation. |
US4672056A (en) * | 1985-11-12 | 1987-06-09 | Abbott Laboratories | Erythromycin A derivatives and method of use |
JPH0633312B2 (en) * | 1986-05-02 | 1994-05-02 | 大正製薬株式会社 | 14-Hydroxyerythromycin derivative and method for producing the same |
US5106961A (en) * | 1987-05-26 | 1992-04-21 | Eli Lilly And Company | Erythromycin ring-contracted derivatives |
US4920102A (en) * | 1988-04-18 | 1990-04-24 | Eli Lilly And Company | Method for treating gastrointestinal disorders |
ATE138925T1 (en) * | 1992-03-19 | 1996-06-15 | Takeda Chemical Industries Ltd | ERYTHROMYCIN DERIVATIVES, PRODUCTION AND USE THEREOF |
-
1993
- 1993-03-19 AT AT93104504T patent/ATE138925T1/en not_active IP Right Cessation
- 1993-03-19 EP EP93104504A patent/EP0561413B1/en not_active Expired - Lifetime
- 1993-03-19 CA CA002092045A patent/CA2092045C/en not_active Expired - Fee Related
- 1993-03-19 DE DE69302938T patent/DE69302938T2/en not_active Expired - Fee Related
- 1993-03-19 US US08/033,777 patent/US5470961A/en not_active Expired - Fee Related
-
1995
- 1995-06-07 US US08/475,557 patent/US5854407A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2092045C (en) | 2004-08-10 |
DE69302938D1 (en) | 1996-07-11 |
DE69302938T2 (en) | 1996-10-17 |
EP0561413B1 (en) | 1996-06-05 |
EP0561413A1 (en) | 1993-09-22 |
US5470961A (en) | 1995-11-28 |
US5854407A (en) | 1998-12-29 |
ATE138925T1 (en) | 1996-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |