CA2093825A1 - Proanthocyanidin polymers having antiviral activity and methods of obtaining same - Google Patents

Proanthocyanidin polymers having antiviral activity and methods of obtaining same

Info

Publication number
CA2093825A1
CA2093825A1 CA002093825A CA2093825A CA2093825A1 CA 2093825 A1 CA2093825 A1 CA 2093825A1 CA 002093825 A CA002093825 A CA 002093825A CA 2093825 A CA2093825 A CA 2093825A CA 2093825 A1 CA2093825 A1 CA 2093825A1
Authority
CA
Canada
Prior art keywords
methods
antiviral activity
proanthocyanidin
proanthocyanidin polymers
obtaining same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002093825A
Other languages
French (fr)
Other versions
CA2093825C (en
Inventor
Michael S. Tempesta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Napo Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2093825A1 publication Critical patent/CA2093825A1/en
Application granted granted Critical
Publication of CA2093825C publication Critical patent/CA2093825C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/60—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2
    • C07D311/62—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with aryl radicals attached in position 2 with oxygen atoms directly attached in position 3, e.g. anthocyanidins

Abstract

The present invention provides for proanthocyanidin polymers with significant antiviral activity. The proanthocyanidin po-lymers can be chemically synthesized or can be isolated from a Croton or a Calophyllum plant species. The present invention en-compasses methods of using proanthocyanidin polymers in treating warm-blooded animals, including humans, infected with par-amyxovaridae such as respiratory syncytial virus, orthomyxovaridae such as influenza A, B and C, and herpes viruses such as Herpes Simplex virus.
CA002093825A 1990-10-12 1991-10-10 Proanthocyanidin polymers having antiviral activity and methods of obtaining same Expired - Lifetime CA2093825C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US59689390A 1990-10-12 1990-10-12
US596,893 1990-10-12
US737,077 1991-07-29
US07/737,077 US5211944A (en) 1990-10-12 1991-07-29 Proanthocyanidin polymers having antiviral activity and methods of obtaining same
PCT/US1991/007679 WO1992006695A1 (en) 1990-10-12 1991-10-10 Proanthocyanidin polymers having antiviral activity and methods of obtaining same

Publications (2)

Publication Number Publication Date
CA2093825A1 true CA2093825A1 (en) 1992-04-13
CA2093825C CA2093825C (en) 2003-01-07

Family

ID=27082674

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002093825A Expired - Lifetime CA2093825C (en) 1990-10-12 1991-10-10 Proanthocyanidin polymers having antiviral activity and methods of obtaining same

Country Status (12)

Country Link
US (2) US5211944A (en)
EP (1) EP0553253B1 (en)
JP (1) JP3448052B2 (en)
KR (1) KR100207949B1 (en)
AT (1) ATE194288T1 (en)
AU (1) AU660631B2 (en)
CA (1) CA2093825C (en)
DE (1) DE69132289D1 (en)
MX (1) MX9101540A (en)
NZ (1) NZ240200A (en)
SG (1) SG52707A1 (en)
WO (1) WO1992006695A1 (en)

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Also Published As

Publication number Publication date
ATE194288T1 (en) 2000-07-15
CA2093825C (en) 2003-01-07
EP0553253A4 (en) 1993-09-15
DE69132289D1 (en) 2000-08-10
SG52707A1 (en) 1998-09-28
EP0553253A1 (en) 1993-08-04
JPH06502413A (en) 1994-03-17
KR930702010A (en) 1993-09-08
WO1992006695A1 (en) 1992-04-30
US5211944A (en) 1993-05-18
EP0553253B1 (en) 2000-07-05
AU660631B2 (en) 1995-07-06
JP3448052B2 (en) 2003-09-16
NZ240200A (en) 1994-04-27
KR100207949B1 (en) 1999-07-15
AU8878091A (en) 1992-05-20
US5494661A (en) 1996-02-27
MX9101540A (en) 1992-06-05

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Effective date: 20111010