CA2094251C - Surgical probe locating system for head use - Google Patents
Surgical probe locating system for head useInfo
- Publication number
- CA2094251C CA2094251C CA002094251A CA2094251A CA2094251C CA 2094251 C CA2094251 C CA 2094251C CA 002094251 A CA002094251 A CA 002094251A CA 2094251 A CA2094251 A CA 2094251A CA 2094251 C CA2094251 C CA 2094251C
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- CA
- Canada
- Prior art keywords
- probe
- body part
- relative
- array
- tip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
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- A61B90/10—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges for stereotaxic surgery, e.g. frame-based stereotaxis
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- Measurement Of Length, Angles, Or The Like Using Electric Or Magnetic Means (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
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Abstract
A system for determining a position of a probe (302) relative to an object such as a head (390) of a body of a patient. The head includes a surface such as a forehead (394) having a contour. The head is placed in a cradle (392) equipped with an arc (393). The cross-sectional images of the head are determined relative to the arc. A hand-held unit (380) optically scans the forehead and the arc. During scanning to generate the cross-sectional images, the optical scanner (380) is used to determine the position of the forehead (394) relative to the cradle (392). During surgery, the optical scanner (380) also determine the position of the forehead (394) relative to a base ring (306). An array (300) for receiving radiation emitted from the probe (302) and from the base ring (306) generates signals indicating the position of the tip of the probe (302) relative to the base ring (306). A stereotactic imaging system selects and displays the image of the head closest to the measured position of the tip of the probe (302).
Description
1 2~~4~~1 SURGICAL PROBE LrOCATING SYST~~I FOR HEAD USE
Backkground of the Invention Precise localization of position has always been critical to neurosurgery. Knowledge of the anatomy of the brain and specific functions relegated to local areas of the brain are critical in planning any neurosurgical proce-dure. Recent diagnostic advances such as computerized tomographic (CT) scans, magnetic resonance imaging (MRI) scanning, and positron emission tomographic (PET) scanning have greatly facilitated preoperative diagnosis and surgi-cal planning. However, the precision and accuracy of the scanning technologies have not become fully available to the neurosurgeon in the operating room. Relating specific structures and locations within the brain during surgery to preoperative scanning technologies has previously been cumbersome, if not impossible.
Stereotactic surgery, first developed 100 years ago, consists of the use of a guiding device which channels the surgery through specific parts of the brain as local-ized by preoperative radiographic techniques. Stereotactic surgery was not widely used prior to the advent of modern scanning technologies as the injection of air into the brain was required to localize the ventricles, fluid con-taining chambers within the brain. Ventriculography carried a significant complication rate and accuracy in localization was marginal.
S..u_mm_a_r~~f the Inven i n It is an object of this invention to provide a system which can determine the position of a probe within a ' head and display an image corresponding to the deterrnined position.
According to one broad aspect the invention provides a system for determining a position of a tip of a probe, which is positioned within an object, relative to cross-sectional images of the object, wherein said cross-sectional images were obtained during pre-operative scanning and are stored in a memory, and wherein said probe has emitters, said system comprising:
means, positioned physically separate from the probe, for detecting output from the emitters and measuring the position of the tip of the probe relative to the object;
means for t tans lat ing the pos it ion of the t ip of the probe relative to the object into a coordinate system corresponding to the cross-sectional images of the object; and means for displaying, on a display screen, the cross-sectional image of the object which corresponds to the measured position of the tip of the probe.
According to another broad aspect the invention provides a system for use with a part of a body of patient, said system comprising:
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part;
means for scanning the body part to create scanned images thereof; and
Backkground of the Invention Precise localization of position has always been critical to neurosurgery. Knowledge of the anatomy of the brain and specific functions relegated to local areas of the brain are critical in planning any neurosurgical proce-dure. Recent diagnostic advances such as computerized tomographic (CT) scans, magnetic resonance imaging (MRI) scanning, and positron emission tomographic (PET) scanning have greatly facilitated preoperative diagnosis and surgi-cal planning. However, the precision and accuracy of the scanning technologies have not become fully available to the neurosurgeon in the operating room. Relating specific structures and locations within the brain during surgery to preoperative scanning technologies has previously been cumbersome, if not impossible.
Stereotactic surgery, first developed 100 years ago, consists of the use of a guiding device which channels the surgery through specific parts of the brain as local-ized by preoperative radiographic techniques. Stereotactic surgery was not widely used prior to the advent of modern scanning technologies as the injection of air into the brain was required to localize the ventricles, fluid con-taining chambers within the brain. Ventriculography carried a significant complication rate and accuracy in localization was marginal.
S..u_mm_a_r~~f the Inven i n It is an object of this invention to provide a system which can determine the position of a probe within a ' head and display an image corresponding to the deterrnined position.
According to one broad aspect the invention provides a system for determining a position of a tip of a probe, which is positioned within an object, relative to cross-sectional images of the object, wherein said cross-sectional images were obtained during pre-operative scanning and are stored in a memory, and wherein said probe has emitters, said system comprising:
means, positioned physically separate from the probe, for detecting output from the emitters and measuring the position of the tip of the probe relative to the object;
means for t tans lat ing the pos it ion of the t ip of the probe relative to the object into a coordinate system corresponding to the cross-sectional images of the object; and means for displaying, on a display screen, the cross-sectional image of the object which corresponds to the measured position of the tip of the probe.
According to another broad aspect the invention provides a system for use with a part of a body of patient, said system comprising:
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part;
means for scanning the body part to create scanned images thereof; and
- 2 -means, responsive to the scanning means, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part;
and wherein the scanning means is adapted to be used prior to an operation and wherein the ultrasound probe is adapted to be used during the operation.
According to yet another broad aspect the invention provides a system for use with a part of a body of a pat ient which has been scanned by a scanning device to create scanned images of the body part, said system comprising:
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part; and means, responsive to the scanning device, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part.
and wherein the scanning means is adapted to be used prior to an operation and wherein the ultrasound probe is adapted to be used during the operation.
According to yet another broad aspect the invention provides a system for use with a part of a body of a pat ient which has been scanned by a scanning device to create scanned images of the body part, said system comprising:
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part; and means, responsive to the scanning device, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part.
- 3 -According to still another broad aspect the invention provides a system for indicating a position within an object, said system comprising:
reference points means having a position in fixed relation to the object for providing reference points;
means for generating images of the object, said images including reference images corresponding to the reference points means;
reference means having a location outside the object for providing a reference;
a probe including a tip having a position;
first means for determining the position of the tip of the probe relative to the reference means;
second means for measuring the position of the reference points means of the object relative to the reference means so that the position of the tip relative reference points means of the object is a known position;
means for translating the known position to the tip of the probe to provide a translated position within a coordinate system corresponding to the images of the object; and means for displaying an image of the object which corresponds to the translated position of the tip of the probe.
Brief Descri tion of the Drawings Figure lA is a perspective illustration of a cylindrical frame structure which is mounted around a patient's head during the scanning process.
- 3a -Figure 1B is a plan view of the rods of the cylindrical frame structure of Figure lA taken along a plane midway between the upper and lower rings.
Figure 1C is a perspective illustration of a reference ring which is mounted by uprights to a patient's head to support the cylindrical frame structure of Figure lA.
Figure 1D is a perspective illustration of the coordinate system of a three dimensional scanned image.
Figure 2A is a perspective view of the caliper frame used to determine the relative position between a position in the head and the phantom base.
- 3b -z~~42~1 ., 4 Figure 2B is a perspective view of the caliper frame of Figure 2A illustrating its angles of adjustment.
Figure 2C is a block diagram of the steps involved T
in the prior art process of determining the position of sur-gical probe relative to the scanned images so that the image corresponding to the probe position can be identified and viewed by the surgeon.
Figure 2D is a perspective illustration of a three dimensional coordinate system of a surgical probe.
Figure 3A is a block diagram of a system according to the invention for indicating the position of a surgical probe within a head on an image of the head.
Figure 3B is a perspective schematic diagram of the microphone array, surgical probe and base ring according to the invention.
Figure 3C is a block diagram of the steps involved in the process according to the invention for determining the position of a surgical probe relative to the scanned images so that the image corresponding to the probe position can be identified and viewed by the surgeon.
Figure 3D is a perspective schematic diagram of an optical scanner used in combination with a cradle.
Figure 3E is a perspective schematic diagram of the microphone array, surgical probe, base ring and optical scanner according to the invention.
Figure 4 is a flow chart of the translational software for translating coordinates from the surgical probe coordinate system to the scanned image coordinate system according to the invention.
Figure 5A is a perspective schematic diagram of an ultrasound probe system according to the invention;
Figures 5B and 5C illustrate ultrasound and scanned images, respectively. .
WO 92/06645 ., Corresponding reference characters indicate corresponding parts throughout the several views of the drawings.
Detailed Descrivtion of the Preferred Embodiments 5 With the advent of modern scanning equipment and techniques, several stereotactic systems have been devel-oped and are presently available. These stereotactic systems allow a surgeon to localize specific points detected on CT, MRI or PET scans which have been previously generated prior to the surgical procedure being performed. In partic-ular, the stereotactic systems allow the selection of spe-cific points detected on the scans to be localized within the brain by the surgeon during the surgical procedure using a mechanical device.
Initially, prior to the operative procedure, some form of localizing device, such as a frame, is attached to the patient's skull using sharp pins. The particular scan or scans which are to be performed are then generated with the head of the patient encircled by the frame. For example, the frame may be comprised of a cylindrical structure 100 as illustrated in perspective in Figure lA.
Structure 100 includes an upper circular ring 102 and a lower circular ring 104 which are interconnected by six vertical rods 106 and three diagonal rods 108. The three diagonal rods 108 diagonally interconnect rings 102 and 104 so that any plane which passes through the cylindrical structure 100 and orthogonally intersects its axis 108 will intersect each of the diagonal rods 108 at a particular point. The resultant spacing between the diagonal and upright rods defines a unique plane within the cylindrical structure 100. For example. as shown in Figure 1B, a scan in a particular plane would show a pattern of nine cross ~~ p p 4 ~ 5 ~~. ~.
sectional views of the rods 106. The unique spacing of these views of the rods, as shown in plane 112 of Figure 1B, would necessarily indicate that the position of the scan plane 112 was parallel to and midway between rings 102 and 104 of the cylindrical structure 100. a As a result of the scanning process, the images obtained are analyzed and the position within the images of the specific marking rods 106, called fudicels, are identi-fied and measured. By measuring the distance between the rods 106, the specific location of a scan with reference to a base plane can be identified. Generally, the lower ring 104 of the cylindrical structure 100 is attached to a ref-erence ring 120 (also known as a BRW head ring) as illus-trated in Figure 1C. As noted above, this ring 120 is supported on the patient's head via uprights 122 attached to the head by the use of sharp pins 124 so that the ring 120 is held firmly in place with respect to the head. The lower ring 104 of the cylindrical structure 100 is mounted to the reference ring 120 attached to the patient's head so that these two rings are in parallel planes.
As shown in Figure 1D, the scanning system (e. g., CT, MRI, PET) which is performing the scanning has a scanned image coordinate system (Xo, Yo, Zo) within which a refer-ence plane RP can be defined by at least three reference points RP1, RP2 and RP3 located on the head 124 of the patient. A computer is then used to calculate a specific position within the brain and a target picked out on the specific image can be approached with a fair degree of accuracy during the surgical procedure.
Although stereotactic surgery allows a surgeon to be guided to a specific point with accuracy. it has not been particularly useful in allowing the surgeon to identify the particular location of a surgical probe within the brain , at any point during the surgical process. Frequently in ~fl942~.
neurosurgery, brain tumors or other target points within the brain are indistinguishable from surrounding normal a tissue and may not be detected even with the use of frozen sections. Moreover, with modern microsurgical techniques, it is essential that the neurosurgeon identify specific structures within the brain which are of critical func-tional importance to the patient. In addition, the bound-aries of these structures must be accurately defined and specifically known to the surgeon during the surgical process. In this way, these tissues will not be disturbed or otherwise damaged during the surgical process resulting in injury to the patient.
In the past, the surgeon has been able to use the stereotactic system in reverse in order to permit the deter-urination of the position of a surgical probe relative to the scanned images so the image corresponding to the probe position can be identified and viewed. However, going in reverse from the patient's brain backwards to find the position of the surgical probe relative to the scan is a cumbersome and time-consuming process. Usually, a spe-cially designed caliper frame 200, as illustrated in Figure 2A, has to be attached to the ring 120 affixed to the patient's head to determine the position of the surgical probe in the head. For example, suppose the surgeon desires to know the position of a tip 201 of a probe 202 in the patient's head. First, the caliper frame 200 is fitted to the reference ring 120 affixed to the patient's head.
Next, the position of probe 202 is positioned on arch 206 and the frame 200 is set to indicate the alpha, beta, gamma and delta angles on scales 208, 210, 212 and 214 that the probe 202 defines with respect to the frame 200, as shown in Figure 2B. Next, the distance 216 from the tip of the probe 202 to the arch 206 is determined.
o~~z~ ~
The caliper frame 200 is then transferred and mounted to a phantom base 250 i.n a manner as illustrated in Figure 2A. The phantom base 250 has a coordinate system (X1, Yl, Z1). Generally, the caliper frame 200 identifies S a point 201 over the phantom base 250. A pointing device 252 is positioned to have its tip 254 at point 201. The X1 - Y1 plane of the phantom base 200 corresponds to a plane parallel to the plane in which the reference points RP1, RP2 and RP3 are located. The (Xl, Y1, Z1) coordinates define the position of point 201. As a result, the posi-tion of point 254 with respect to the Xl - Y1 plane and, therefore, with respect to the reference plane RP is now known. A computer can now be used to calculate the specific position within the brain and the particular scan which corresponds to the calculated position can now be accessed and viewed on a scanning system.
In summary, this prior art process as shown in Figure 2C identifies the location of the tip 201 of the surgical probe 202 for the surgeon. Initally, the surgeon positions the probe 202 on the caliper frame 200, which is attached to the head, at the position desired within the head. The caliper frame 200 is then removed from the . patient's head and transferred to the phantom base 250.
The pointing device 252 is then positioned at point 254 which is essentially coaxial with point 201 of the tip of the probe. The pointing device 252 then indicates the position of the tip of the probe in the phantom base coordi-nate system (Xl, Yl, Zl). Finally, these coordinates are used to determine the scanned image coordinates (Xo, Yo.
Zo) so that the image corresponding to the probe position can be displayed.
After this cumbersome and time-consuming process, the surgeon has now determined the position of the tip 201 of the probe 202 with respect to the scanned images and can now view the image corresponding to the probe position to decide the next step in the surgical procedure. This entire process takes approximately ten to fifteen minutes and increases the risks of intraoperative contamination as the base of the calipers are nonsterile. Because of these con-siderations, stereotactic surgery is nvt commmonly employed in most procedures. Furthermore, the minimal accuracy it affords is generally insufficient for modern microsurgical techniques. Consequently, stereotactic surgery is not gen-erally available to the majority of certain patients under-going surgery.
Comparing Figures 1D and 2A, it can be seen that it is necessary for the surgeon to knew the specific loca tion of the tip 201 of the surgical probe 202 with respect to the scanned image coordinate system (Xo, Yo, Zo) of the particular scans that were preoperatively performed. In other words, the surgical probe 202 has a particular coordi-nate system (X2, Y2, Z2) which is illustrated in Figure 2D. Ideally, the surgical probe coordinate system (X2, Y2, ZZ) must be related to the scanned image coordinate system (Xo, Yo, Zo). The prior art as illustrated in Figure ZB
has suggested relating these coordinate systems via the phantom base coordinate system (X1, Y1, Zl). However, as noted above, this relational process is inaccurate, time-consuming and cumbersome. The invention uses a 3D digi-tizer system to locate the position of the tip 201 of the surgical probe 202 and to directly relate the surgical probe coordinate system (X2, Y2, Z2) to the scanned image coordinate system (Xo, Yo. ZoW
In particular, an off-the-shelf, three dimen-sional sonic digitizer such as Model GP-8-3D produced by Scientific Accessories Corporation is used to deter mine the ~~94251 10 position of the probe. As shown in Figure 3A, the 3D digi-tizer system includes a microphone array 300 which is gener-ally mounted in the operating room on the ceiling or in some other position so that it is in a line of sight with S the surgical probe 302 that is being used. As will be described in greater detail below, the probe 302 includes transmitters such as sound emitters thereon which interact with the microphone array 300 so that the position of the tip of surgical probe 302 is known at any particular instant in time. The 3D digitizer system also includes.a tempera-ture compensation emitter 304 associated with the micro-phone array 300. Furthermore, mounted to the ring 120 (Figure 1C) affixed to the patient's head is a base ring 306 which is coaxial and parallel with the plane defined by reference ring 120. This base ring 306 includes a plural-ity of transmitters as will be described below which inter-act with the microphone array 300 so that the relative posi-tion of the base ring 306 can be determined any particular instant in time. Signal generator 308 generates a signal which is provided through a multiplexer 310 to the temperature compensation emitter 304, surgical probe 302, and base ring 306. Usually, temperature compensation emitter 304 is activated by the signal generator 308 via multiplexer 310 to emit a signal which is received by the microphone array 300. Each of the signals received by each of the microphones of the array 300 is provided to a digitizer 312 which digitizes the signals and provides the digitized signals to computer 314 which includes a spatial acquisition and recording (SAR) program 316 which acquires and records spatial coordinates based on the digitized signals. For example, program 316 may be the SACDAC
program licensed by PIXSYS of Boulder, Colorado. This program evaluates the digitized signals emitted by the temperature compensation emitter 304 to determine the reference standards. i.e., the velocity of the radiation through the air. For example, depending on the temperature of the air in the operating room, the period of time that it takes from the instant that the temperature compensation emitter 304 is actuated to radiate a signal until the instant that each of the microphones of the array 300 receives the emitted signal will vary. The SAR program 316 knows, through calibration, the distance between the tem-perature compensation emitter 304 and each of the micro-phones of the array 300. Therefore, the SAR program 316 can imme~3iately calculate the velocity of the signals being transmitted. This velocity establishes a reference for determining the position of the surgical probe 302 and the base ring 306.
Next, the emitters of the base ring 306 are activated so that the position of the base ring 306 can be determined. At this point, the emitters of the base ring 306 are successively energized and the radiation transmit-ted by these emitters is detected by the microphone array 300. The signal generated by the microphones from this radiation is digitized and evaluated by the SAR program 316 to determine the position of each of the emitters of the base ring 306. Once the positions of the base ring emit-ters have been determined by the SAR program 316, standard geometrical computations are performed by the SAR program to determine the plane defined by the base ring 306 with respect to the microphone array 300.
Digitizer 312 then signals multiplexer 310 to provide the signal generated by signal generator 308 to the surgical probe 302. At this point, the emitters of the sur-gical probe 302 are successively energized and the radiation transmitted by these emitters is detected by tree microphone z~~~2~~
array 300. The signal generated by the microphones from this radiation is digitized and evaluated by the SAR program 316 to determine the position of each of the emitters of the surgical probe 302. Once the positions of the probe emitters have been determined by the SAR program 316, standard geometrical triangulation is performed by the SAR
program to determine the location of the tip of the surgi-cal probe with respect to the microphone array 300.
Therefore, by using the 3D digitizer system, the position of the base ring 306 and the position of the sur-gical probe 302 relative to the base ring 306 can be deter-mined by the SAR program 316. As noted above, the base ring 306 is mounted to the reference ring 120 (Figure 1C) and is essentially coplanar therewith so that the base ring 306 defines the reference plane RP of the scanned image coordinate system illustrated in Figure 1D.
Computer 314 includes translational software 318 which then translates the coordinates of surgical probe coordinate system illustrated in Figure 2D into the scanned image coordinate system illustrated in Figure 1D. As a result of this translation, computer 314 has now determined the particular scanned image of the preoperative scan on which the tip of the surgical probe 302 would be located.
The system includes a tape drive 320, accessed through a local area network (LAN) 321, in which each of the images of the preoperative scan are stored. The translated coordinates generated by translational software 318 are provided to the stereotactic image display software 322, also resident within computer 314, and identify the par-ticular scanned image which is to be viewed by the surgeon.
The identified image is selected by the stereotactic imag-ing system 324 which recreates the image from the data stored in tape drive 320 and displays it on a high ~~~42~~
resolution display 326. Stereotactic image display software 322 and stereotactic image system 324 may be any off-the-shelf system such as manufactured by Stereotactic Image Systems, Inc. of Salt Lake City, Utah.
Referring to 3B, a perspective illustration of the microphone array 300, temperature compensation emitter 304, surgical probe 302 and base ring 306 are illustrated.
Microphone array 300 includes a plurality of microphones 350, the outputs of which are connected to 3D digitizer 312. Adjacent to the microphone array 300 is a temperature compensating emitter 304 which selectively emits signals used by the SAR program in calibration to determine the velocity of the radiation. For example, in the Scientific Accessories Corporation Model GP-8-3D, a sonic digitizer is used. In this case, the speed of sound being transmitted from the temperature compensation emitter 304 to the micro-phones 350 is calculated by the SAR program to determine the speed at which the sound is being transmitted through the air. Since this system is very accurate and the speed of sound varies fairly significantly with respect to the temperature of the air, the temperature compensation emitter 304 allows the 3D digitizer system to compensate for changes in the air temperature in the operating room.
Surgical probe 302 comprises a bayonet surgical forceps modified to carry at least two sound emitters thereon which are essentially coaxial on axis 362 with the tip of the forceps. The emitters are in line and immediately below the surgeon's line of sight through the forceps so that the line of sight is not blocked. In general, the microphone array 350 is attached to the operating light above the patient's head so that it is in direct line of sight with the forceps as they are being used by the surgeon. The microphones 350 listen to the sound emitted from the sequen-tial energization of the emitters 360 on the forceps. The ~~~ 421 14 SAR software 316 measures the time of transmission from each of the sound emitters 360 on the forceps to the micro-phones 350. By comparing these times, the position of both emitters 360 and, therefore, the tip of the forceps can be calculated by the SAR program 316. ' Base ring 306 is affixed to the reference ring 120 attached to the patient's head and is essentially coplanar with the reference points RP1, RP2 and RP3. Base ring 306 includes a plurality of emitters 370 thereon which are connected to multiplexer 310 and energized by signal generator 308. Each one of these emitters 370 is sequen-tially energized so that the radiation emitter thereby is received by the microphones 350 of array 300. The emitters 370 are preferably positioned 90° apart with the center emitter being located at the anterior of the head. This permits base ring 306 to be mounted around the head so that all three emitters are in line of sight with the array.
The resulting signals are digitized by digitizer 312 so that the SAR program 316 is able to determine the plane in which the emitters 370 are located. This plane essentially defines the reference plane because it is coplanar with the reference points RP1, RP2 and RP3. By determining the posi-tion of the reference plane, translational software 318 is now able to take the coordinate position of the probe 302 and translate it from the surgical probe coordinate system of Figure 2D into the scanned image coordinate system as illustrated in Figure 1D. As a result, the particular scanned image which corresponds to the position of the probe can be identified and displayed for viewing by the surgeon.
The surgical probe 302 is generally a bayonet cauterizing device which has a bundle of wire 364 attached thereto. Therefore, the wires required to connect the ~~'~~ ~ ~a~
emitters 360 to the multipleaer 310 are part of the bundle of wires 369 which connect the forceps to its electrical power source and the surgeon is familiar with handling such forceps connected to a wire bundle. Therefore, there is no 5 inconvenience to the surgeon in using such a probe and the surgeon is familiar with handling such a forceps connected to a wire bundle.
Base ring 306 is one apparatus for determining and positioning the reference points RP1, RP2 and RP3 with 10 respect to the microphone array 300. An advantage of the base ring 306 is that each time the patient's head is moved the base ring 306 is energized to define the reference plane. This allows the surgeon to move the patient's head during surgery. Alternatively, the reference points RP1, 15 RF2 and RP3 can be established by using a reference mode of the 3D digitizer 312. In particular, the tip of probe 302 is positioned on each of the reference points RP1, RP2 and RP3 and actuated to emit a signal to the microphone array 300 so that the position of the tip can be determined at each of these points. This is performed during a reference mode of operation of the 3D digitizer 312 so that the SAR
program 3i6 calculates, at the end of the execution of this mode, the position of the reference points RP1, RP2 and RP3.
This requires that the reference points have to be reestab-lished before the position of the surgical probe is deter-mined to avoid changes in the reference plane due to move-ment of the head. On the ether hand, one advantage of this approach is that the use of the reference ring 120 may be eliminated. In particular, it is possible that the refer-3U eiice pins 122 can be permanently affixed to the skull of the patient. For example, these pins may be radiolucent surgical screws which are embedded in the patient's skull and which have radiopaque tips. These screws would be .. 209425. 16 affixed to the patient's skull before surgery and before the preoperative scanning so the radiopaque tips would pro-vide a constant reference during scanning and throughout the stereotactic surgical procedure. During the actual surgery, the probe would be used to indicate the position of each of the radiopaque tips before the probe position was determined. By eliminating the need for the reference ring 120, other advantages are also achieved. For example, generally the preoperative scanning must be done under anesthetic because the reference ring 120 interferes with intubation. Therefore, intubation must occur before the reference ring is affixed to the skull. By eliminating the need for the reference ring 120 and using surgical screws to identify the reference points RP1, RP2 and RP3. the preoperative scanning can be performed without the need for incubation and the anesthesia accompanying it. In one alternative embodiment, it is contemplated that the emitters 370 may each be separately mounted to a screw or other fixed structure positioned at one of the reference points.
In summary, this process according to the inven-tion is illustrated in Figure 3C and identifies the loca-tion of the tip of the surgical probe 202 for the surgeon.
Initially, the reference plane is determined by energizing the base ring 306 or by positioning the probe 302 at the reference points (as described herein). Next, the surgeon positions the probe in the position desired within the head. The emitters of the probe are then energized so that the probe position is measured and determined in the surgi-cal probe coordinate system (X2,Y2.Z2). Next, the trans-lational software 318 converts the surgical probe coordinate system into the scanned image coordinate system (Xo,Yo,Zo) so that the image corresponding to the probe position can be displayed. ' 1~
Referring to Figure 3D, a perspective illustra-tion of a patient's head 390 in a cradle 392 during the scanning process is shown. As will be described below, optical scanner 380, having emitters 381 thereon, is employed to determine the position of the head 390 relative to a cradle 392 positioned on the head.
Referring to 3E, a perspective illustration of the microphone array 300, temperature compensation emitter 304, surgical probe 302 and optical scanner 380 are illus-trated. Microphone array 300 includes a plurality of micro-phones 350, the outputs of which are connected to 3D digi-tizer 312. The microphone array 300 provides a fixed frame of reference to which the position of probe 302 is measured and to which the position of the head 390, relative to the cradle 392, is measured. As a result. the position of the probe 302 relative to the head 390 at any instant in time can be determined.
Adjacent to the microphone array 300 is a temper-ature compensating emitter 304 which selectively emits signals used by the SAR program in calibration to determine the velocity of the radiation. For example, in the Scientific Accessories Corporation Model GP-8-3D, a sonic digitizer is used. In this case, the speed of sound being transmitted from the temperature compensation emitter 304 to the microphones 350 is calculated by the SAR program to determine the speed at which the sound is being transmitted through the air. Since this system is very accurate and the speed of sound varies fairly significantly with respect to the temperature of the air, the temperature compensation 3U emitter 304 allows the 3D digitizer system to compensate for changes in the air temperature in the operating room.
Surgical probe 302 comprises a bayonet surgical forceps modified to carry at least two sound emitters 360 thereon which are essentially coaxial on axis 362 with the ~~94251 tip of the forceps. The emitters are in line and immedi-ately below the surgeon's line of sight through the forceps so that the line of sight is not blocked. In general, the microphone array 350 is attached to the operating room light above the patient's head so that it is in direct line of sight with the forceps as they are being used by the surgeon. The microphones 350 listen to the sound emitted from the sequential energization of the emitters 360 on the forceps. The SAR software 316 measures the time of trans-mission from each of the sound emitters 360 on the forceps to the microphones 350. By comparing these times, the position of both emitters 360 and, therefore, the tip of the forceps can be calculated by the SAR program 316.
Optical scanner 380 is generally located aver the patient's head 390 and is used during scanning to establish the position of the head 390 relative to the cradle 392 thereby to relate the frame of reference of the cross sectional scans to the forehead 394. Scanner 380 is also used during surgery to establish the position of the head 390 relative to the cradle 392 thereby to relate the frame of reference of the probe 302 to the forehead 394.
During the preoperative scanning process as shown in rigure 3D, when the cross sectional images of the head are created, the patient's head lies temporarily in cradle 392. The cradle includes an arc 393 of radiopaque material so that it appears in at least some of the cross sectional scans. As a result, the arc 393 defines a plane relative to the head 390. During scanning, this plane can be defined as the 0,0,0 plane for convenience. After the head is placed iii the cradle, optical scanner 380 is used to establish the position of the cradle 392 and its attached arc 393 relative to the forehead 394. In particular, the optical scanner 380 scans both the forehead and the arc 393 of the cradle 392 and, via computer 396 employing forehead fitting software 398, determines the position of the arc 393 of the cradle 392 relative to the forehead 394. The forehead fitting software may be any off-the-shelf or custom software which graphs a set of points so that a curve defining the contour of the forehead can be calcu-lated, a curve defining the arc can be calculated, and a curve defining the relative position of the forehead and the arc can be calculated. Since the position of the cross sectional scans relative to the radioopaque arc 393 is known (because the cradle arc defines the 0,0,0 plane) and since the position of the arc 393 of the cradle 392 rela-tive to the forehead 394 is known (because of the scanning by the optical scanner), then the position of the cross sectional scans relative to the forehead is known and can be calculated by translational software 316.
During surgery, a base ring 306 is firmly affixed to the head. The base ring 306 does not have to be posi-tioned in the same location relative to the head as the arc was during the scanning process when the cross sectional images were created. The base ring 306 used during surgery includes emitters 370 which communicate with the array 300 to establish the position of the base ring 306. As a result, the base ring 306 defines a plane relative to the head 390. After affixing the base ring to the head, optical scanner 380 is used prior to or during the surgery to establish the position of the base ring 306 relative to the forehead 394. In particular, the optical scanner 380 scans both the forehead and the base ring 306 and, via computer 396 employing forehead fitting software 398, determines the position of the base ring 306 relative to the forehead 392. Since the position of the probe relative to the base ring is known (because of communication via the array) and since the position of the base ring relative to the fore-head is known (because of the scanning by the optical scanner), then the position of the probe relative to the forehead is known and can be calculated by translational 5 software 316. Since the position of the cross sectional images relative to the forehead is also known (from the preoperative scanning process), the end result is that the position of the probe relative to the cross sectional images is known so that the position of the tip of the probe on 10 the closest cross sectional image can be displayed.
Optical scanner 380 and computer 396 are a standard, off the shelf scanner used to scan an object to determine its three-dimensional shape. For example, a limb scanner such as PIXSYS Optical Scanner used to develop 15 three-dimensional models for artificial limbs may be used.
The scanner 380 emits a laser beam or other optical beam toward the arc 393 and the forehead 394 and receives the light reflected there through an array of linear chip cameras such as CCD (charge coupled device) cameras. By 20 evaluating the position of the reflected light using the camera array, the optical scanner 380, including a computer 396, determines the shape and, thus, the contour of the forehead 394, the shape of the arc 393 of cradle 392 and the relative position of the forehead and the arc 393.
Computer 396 indicates to the translational software 316 of computer 314, which is a part of the system as illustrated in Fig. 3A, the position of the probe 302 relative to the forehead 392. The translational software 316 then coverts this indicated position into the coordinate system of the cross sectional scanned images. As a result, the particu-lar scanned image which corresponds to the position of the probe can be identified and displayed on display 326 (Fig.
3A) for viewing by the surgeon.
The surgical probe 302 is generally a bayonet cauterizing device which has a bundle of wire 364 attached thereto. Therefore, the wires required to connect the emitters 360 to the multiplexer 310 are part of the bundle of wires 364 which connect the forceps to its electrical power source. Surgeons are generally familiar with handling such forceps connected to a wire bundle. Therefore, there is no inconvenience to the surgeon in using such a probe and the surgeon is experienced with handling such a forceps connected to a wire bundle.
One advantage of the optical scanner 380 is that it eliminates the need for a ring or pins to be attached to the patient's head during the preoperative scanning process.
Each time the patient's head is placed in a cradle, the optical scanner 38U can be used to scan the head and cradle to redefine their relative position without the need for any contact. The reference ring (i.e., arc) on the head is, therefore, temporary. By eliminating the need for a permanent reference ring 120 or reference pins RP1-RP3, other advantages are also achieved. For example, generally the preoperative scanning must be done under anesthetic because the reference ring 120 interferes with intubation or it must be done after pins are affixed to the head.
Therefore, intubation must occur before the reference ring is affixed to the skull. By eliminating the need for the permanent reference ring 120 and/or reference pins, and by using the contour of the forehead to define a reference point, the preoperative scanning can be performed without the need for intubation and the anesthesia accompanying it.
In summary, during the preoperative scanning process the patient simply lies in a U-shaped cradle attached to the end of a CT or MRI table. Above the patient's face is an arc providing the reference plane.
All scans are obtained with reference to and preferably parallel to this arc defining the reference or base plane.
The optical scanner relates the forehead contour to this arc so that the relation of the forehead to the scans is known.
In the operating room, the patient's head is again scanned with the optical scanner but this time the arc over the patient's head is base ring 306. The reference emitters attached to the base ring define the operative reference system. Therefore, the forehead is again related to the base ring by the optical scanner to define a new reference system; this time the new reference system is the operating room. The computer then matches the forehead contours obtained in the operating room and the scanning room to relate the two reference systems. In effect, the forehead is a "bridge" between the reference system of the preoperative scanner and the reference system of the operating room.
The cradle does not have to appear in the actual scans. The primary purpose of the cradle is to keep the patient's head from moving so that all scans are obtained with the same relationship to the arc.
Referring to Figure 4, a flow chart of the opera-tion of the translational software 318 is illustrated. Ini-tially, the surgeon locates the probe 302 in the position which is to be determined. (If a base ring 306 is not being used to identify the location of the reference plane, the initial step is for the surgeon to use the reference mode of the 3D digitizer 312 to identify the reference plane by locating the surgical probe tip at several points in the plane.) The system initializes at step 400 so that trans-lational software opens a window menu at step 402 of a 23 ~~~~~~.
multitasking program such as DESQ VIEW distributed by quarterdeck Office Systems of Santa Monica, California.
Such software permits simultaneous execution of multiple software programs. In general, once a program is selected for actuation, it continues to run either in the foreground or in the background until deactuated.
The translational software continues initializing by selecting the stereotactic imaging system and actuating the stereotactic imaging system in the foreground by opening the stereotactic window at step 404. Thereafter, the trans-lational software returns to the window menu at step 406 moving the stereotactic image display software to the back-ground and selects the digitizer window at step 408 to actuate the digitizer in the foreground. The computer is then ready to be actuated by the foot switch.
The surgeon then actuates a foot pedal or other switch which indicates that the system should perform a computation. Actuation of the foot switch is essentially the beginning of the start step 410. Upon actuation, the digitizer energizes calibration by the temperature compen-sation emitter 304 to determine the velocity of the sound waves, energizes the emitters of the base ring 306 to locate the reference plane and energizes the emitters of the surgical probe 302 to locate the position of the t~: of the probe 302. The signals generated by the microphone array are digitized so that the SAR program 316 determines the coordinates of the tip of the surgical probe. At step 412, the translational software 318 selects the coordinates from the SAR program.
Next, the window menu is again accessed at step 414 and the window menu switches to the stereotactic image system software to the foreground at step 416 to specifi-cally control the operation of the stereotactic imaging system 324. At this point, the translational software 318 issues an F1 command to the stereotactic image display soft-ware 32Z which in turn prepares the stereotactic imaging system 324 to accept coordinates. At step 420, the window menu is again selected so that at step 422 the computer switches the digitizer window into the foreground. At step 424, the digitizer window menu is accessed and coordinate translation is selected. At. step 426, the digitizer begins calculating the coordinates and at step 928 the coordinate calculation is ended. The translational software then returns to the digitizer window menu at step 430, switches windows to place the stereotactic image system software in the foreground at 432 to prepare it for receiving the coordinates and again returns to the main window menu at step 434. Finally, the coordinate information is trans-lated, including any necessary manipulation, and trans-ferred to the stereotactic image display software 322 at step 436 which actuates the stereotactic imaging system 324 to select the particular image from the tape drive 320 and display it on high resolution display 326. The stereotactic image display software 322 instructs the stereotactic imaging system 329 to display the image closest to trans-ferred coordinates and to display a cursor on the display 326 at the coordinates which corresponds to the position of the tip of the probe. Thereafter, the computer 314 is in a standby mode until the foot switch of the surgeon is again actuated to execute the translational software beginning with the start step 410.
The translation that occurs in step 436 depends on the position of the surgical probe coordinate system relative to the scanned image coordinate system and the units of measure. In the preferred embodiment, the systems are coaxial and the units of measure are the same so that algebraic adjustment is unnecessary. However, it is con-templated that the coordinates systems may not be coaxial, in which case translation would require arithmetic and/or trigonometric calculations. Also, the sequence, e.g., (XZ, Y2, Z2), in which the coordinates are generated by the digitizer may be different than the sequence, e.g., (Xo, Yo, Zo), in which stereotactic image system software receives coordinates. Therefore, the sequence in which the coordinates are transferred may have to be reordered.
Referring to Figure SA, a system employing an ultrasound localizes is illustrated. Reference character 500 refers to an ultrasound probe which may be used in the operating room to scan the brain. The ultrasound probe 500 includes a plurality of at least three emitters 502 which communicate with the array 300 to define the plane in which the ultrasound probe is scanning. Emitters 502 are ener-gized via line 504 by multiplexes 310 as in the other systems illustrated above. The radiation emitted by emitters 502 is received by array 300 to determine the plane in which the ultrasound probe 500 is positioned. The ultrasound probe is also connected via line 506 to a com-puter which analyzes the ultrasound scanning and provides the analyzed information to a work station 510 which displays the scanned image. Since the array 300 can determine the position of the ultrasound probe 500 at any point in time, via digitizer 312, the particular plane of the image displayed on work station 510 is known. The position of the head of the gatient can be determined by attaching a base ring with emitters to the head, as noted above, or by scanning the forehead with an optical scanner having emitters thereon, as noted below.
For example, such an ultrasound image is illus-trated in Figure 5B. The surgeon can then call up the similar image on the display 326 of the stereotactic imaging system 324 such as illustrated in Figure 5C. Alternatively, computer 508 may be linked to the stereotactic imaging system 324 directly to define the particular image plane illustrated on work station 510 so that display 326 can display the corresponding scanned image. As a result, the image from the ultrasound system, as illustrated on work station 510, is shown on one monitor and may be compared to a cross section to the images obtained either by CT, MRI or PET scanning. The cross section through the three dimen-sional data set as developed by the ultrasound system is determined by a high speed graphics work station, such as manufactured by Silicon Graphics. This allows the interpre-tation of the ultrasound scans as the anatomy from the MRI, CT or PET scans can be seen directly. Furthermore, the ultrasound system allows scanning in the operating room.
Since the brain tissue is elastic and the position of various tissue may change from time to time, use of an ultrasound scan in the operating room permits a more definite localization of various brain tissues.
Alternatively, the system may be used for deter-mining a position of the ultrasound probe relative to a head of a body of a patient. The probe 500 is positioned to scan the head 394 with an array 300 positioned adjacent the probe. At least three emitters 502 permit determina-tion of the position of the ultrasound probe relative to the array. Optical scanner 380, having emitters 381 (Fig.
3D) permit determination of the position of the head rela-tive to the array. Computer 396 translates the position of the ultrasound probe into a coordinate system corresponding to the position of the head.
In view of the above, it will be seen that the several objects of the invention are achieved and other advantageous results attained.
~~~~2~~.
As various changes could be made in the above constructions without departing from the scope of the invention, it is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense.
reference points means having a position in fixed relation to the object for providing reference points;
means for generating images of the object, said images including reference images corresponding to the reference points means;
reference means having a location outside the object for providing a reference;
a probe including a tip having a position;
first means for determining the position of the tip of the probe relative to the reference means;
second means for measuring the position of the reference points means of the object relative to the reference means so that the position of the tip relative reference points means of the object is a known position;
means for translating the known position to the tip of the probe to provide a translated position within a coordinate system corresponding to the images of the object; and means for displaying an image of the object which corresponds to the translated position of the tip of the probe.
Brief Descri tion of the Drawings Figure lA is a perspective illustration of a cylindrical frame structure which is mounted around a patient's head during the scanning process.
- 3a -Figure 1B is a plan view of the rods of the cylindrical frame structure of Figure lA taken along a plane midway between the upper and lower rings.
Figure 1C is a perspective illustration of a reference ring which is mounted by uprights to a patient's head to support the cylindrical frame structure of Figure lA.
Figure 1D is a perspective illustration of the coordinate system of a three dimensional scanned image.
Figure 2A is a perspective view of the caliper frame used to determine the relative position between a position in the head and the phantom base.
- 3b -z~~42~1 ., 4 Figure 2B is a perspective view of the caliper frame of Figure 2A illustrating its angles of adjustment.
Figure 2C is a block diagram of the steps involved T
in the prior art process of determining the position of sur-gical probe relative to the scanned images so that the image corresponding to the probe position can be identified and viewed by the surgeon.
Figure 2D is a perspective illustration of a three dimensional coordinate system of a surgical probe.
Figure 3A is a block diagram of a system according to the invention for indicating the position of a surgical probe within a head on an image of the head.
Figure 3B is a perspective schematic diagram of the microphone array, surgical probe and base ring according to the invention.
Figure 3C is a block diagram of the steps involved in the process according to the invention for determining the position of a surgical probe relative to the scanned images so that the image corresponding to the probe position can be identified and viewed by the surgeon.
Figure 3D is a perspective schematic diagram of an optical scanner used in combination with a cradle.
Figure 3E is a perspective schematic diagram of the microphone array, surgical probe, base ring and optical scanner according to the invention.
Figure 4 is a flow chart of the translational software for translating coordinates from the surgical probe coordinate system to the scanned image coordinate system according to the invention.
Figure 5A is a perspective schematic diagram of an ultrasound probe system according to the invention;
Figures 5B and 5C illustrate ultrasound and scanned images, respectively. .
WO 92/06645 ., Corresponding reference characters indicate corresponding parts throughout the several views of the drawings.
Detailed Descrivtion of the Preferred Embodiments 5 With the advent of modern scanning equipment and techniques, several stereotactic systems have been devel-oped and are presently available. These stereotactic systems allow a surgeon to localize specific points detected on CT, MRI or PET scans which have been previously generated prior to the surgical procedure being performed. In partic-ular, the stereotactic systems allow the selection of spe-cific points detected on the scans to be localized within the brain by the surgeon during the surgical procedure using a mechanical device.
Initially, prior to the operative procedure, some form of localizing device, such as a frame, is attached to the patient's skull using sharp pins. The particular scan or scans which are to be performed are then generated with the head of the patient encircled by the frame. For example, the frame may be comprised of a cylindrical structure 100 as illustrated in perspective in Figure lA.
Structure 100 includes an upper circular ring 102 and a lower circular ring 104 which are interconnected by six vertical rods 106 and three diagonal rods 108. The three diagonal rods 108 diagonally interconnect rings 102 and 104 so that any plane which passes through the cylindrical structure 100 and orthogonally intersects its axis 108 will intersect each of the diagonal rods 108 at a particular point. The resultant spacing between the diagonal and upright rods defines a unique plane within the cylindrical structure 100. For example. as shown in Figure 1B, a scan in a particular plane would show a pattern of nine cross ~~ p p 4 ~ 5 ~~. ~.
sectional views of the rods 106. The unique spacing of these views of the rods, as shown in plane 112 of Figure 1B, would necessarily indicate that the position of the scan plane 112 was parallel to and midway between rings 102 and 104 of the cylindrical structure 100. a As a result of the scanning process, the images obtained are analyzed and the position within the images of the specific marking rods 106, called fudicels, are identi-fied and measured. By measuring the distance between the rods 106, the specific location of a scan with reference to a base plane can be identified. Generally, the lower ring 104 of the cylindrical structure 100 is attached to a ref-erence ring 120 (also known as a BRW head ring) as illus-trated in Figure 1C. As noted above, this ring 120 is supported on the patient's head via uprights 122 attached to the head by the use of sharp pins 124 so that the ring 120 is held firmly in place with respect to the head. The lower ring 104 of the cylindrical structure 100 is mounted to the reference ring 120 attached to the patient's head so that these two rings are in parallel planes.
As shown in Figure 1D, the scanning system (e. g., CT, MRI, PET) which is performing the scanning has a scanned image coordinate system (Xo, Yo, Zo) within which a refer-ence plane RP can be defined by at least three reference points RP1, RP2 and RP3 located on the head 124 of the patient. A computer is then used to calculate a specific position within the brain and a target picked out on the specific image can be approached with a fair degree of accuracy during the surgical procedure.
Although stereotactic surgery allows a surgeon to be guided to a specific point with accuracy. it has not been particularly useful in allowing the surgeon to identify the particular location of a surgical probe within the brain , at any point during the surgical process. Frequently in ~fl942~.
neurosurgery, brain tumors or other target points within the brain are indistinguishable from surrounding normal a tissue and may not be detected even with the use of frozen sections. Moreover, with modern microsurgical techniques, it is essential that the neurosurgeon identify specific structures within the brain which are of critical func-tional importance to the patient. In addition, the bound-aries of these structures must be accurately defined and specifically known to the surgeon during the surgical process. In this way, these tissues will not be disturbed or otherwise damaged during the surgical process resulting in injury to the patient.
In the past, the surgeon has been able to use the stereotactic system in reverse in order to permit the deter-urination of the position of a surgical probe relative to the scanned images so the image corresponding to the probe position can be identified and viewed. However, going in reverse from the patient's brain backwards to find the position of the surgical probe relative to the scan is a cumbersome and time-consuming process. Usually, a spe-cially designed caliper frame 200, as illustrated in Figure 2A, has to be attached to the ring 120 affixed to the patient's head to determine the position of the surgical probe in the head. For example, suppose the surgeon desires to know the position of a tip 201 of a probe 202 in the patient's head. First, the caliper frame 200 is fitted to the reference ring 120 affixed to the patient's head.
Next, the position of probe 202 is positioned on arch 206 and the frame 200 is set to indicate the alpha, beta, gamma and delta angles on scales 208, 210, 212 and 214 that the probe 202 defines with respect to the frame 200, as shown in Figure 2B. Next, the distance 216 from the tip of the probe 202 to the arch 206 is determined.
o~~z~ ~
The caliper frame 200 is then transferred and mounted to a phantom base 250 i.n a manner as illustrated in Figure 2A. The phantom base 250 has a coordinate system (X1, Yl, Z1). Generally, the caliper frame 200 identifies S a point 201 over the phantom base 250. A pointing device 252 is positioned to have its tip 254 at point 201. The X1 - Y1 plane of the phantom base 200 corresponds to a plane parallel to the plane in which the reference points RP1, RP2 and RP3 are located. The (Xl, Y1, Z1) coordinates define the position of point 201. As a result, the posi-tion of point 254 with respect to the Xl - Y1 plane and, therefore, with respect to the reference plane RP is now known. A computer can now be used to calculate the specific position within the brain and the particular scan which corresponds to the calculated position can now be accessed and viewed on a scanning system.
In summary, this prior art process as shown in Figure 2C identifies the location of the tip 201 of the surgical probe 202 for the surgeon. Initally, the surgeon positions the probe 202 on the caliper frame 200, which is attached to the head, at the position desired within the head. The caliper frame 200 is then removed from the . patient's head and transferred to the phantom base 250.
The pointing device 252 is then positioned at point 254 which is essentially coaxial with point 201 of the tip of the probe. The pointing device 252 then indicates the position of the tip of the probe in the phantom base coordi-nate system (Xl, Yl, Zl). Finally, these coordinates are used to determine the scanned image coordinates (Xo, Yo.
Zo) so that the image corresponding to the probe position can be displayed.
After this cumbersome and time-consuming process, the surgeon has now determined the position of the tip 201 of the probe 202 with respect to the scanned images and can now view the image corresponding to the probe position to decide the next step in the surgical procedure. This entire process takes approximately ten to fifteen minutes and increases the risks of intraoperative contamination as the base of the calipers are nonsterile. Because of these con-siderations, stereotactic surgery is nvt commmonly employed in most procedures. Furthermore, the minimal accuracy it affords is generally insufficient for modern microsurgical techniques. Consequently, stereotactic surgery is not gen-erally available to the majority of certain patients under-going surgery.
Comparing Figures 1D and 2A, it can be seen that it is necessary for the surgeon to knew the specific loca tion of the tip 201 of the surgical probe 202 with respect to the scanned image coordinate system (Xo, Yo, Zo) of the particular scans that were preoperatively performed. In other words, the surgical probe 202 has a particular coordi-nate system (X2, Y2, Z2) which is illustrated in Figure 2D. Ideally, the surgical probe coordinate system (X2, Y2, ZZ) must be related to the scanned image coordinate system (Xo, Yo, Zo). The prior art as illustrated in Figure ZB
has suggested relating these coordinate systems via the phantom base coordinate system (X1, Y1, Zl). However, as noted above, this relational process is inaccurate, time-consuming and cumbersome. The invention uses a 3D digi-tizer system to locate the position of the tip 201 of the surgical probe 202 and to directly relate the surgical probe coordinate system (X2, Y2, Z2) to the scanned image coordinate system (Xo, Yo. ZoW
In particular, an off-the-shelf, three dimen-sional sonic digitizer such as Model GP-8-3D produced by Scientific Accessories Corporation is used to deter mine the ~~94251 10 position of the probe. As shown in Figure 3A, the 3D digi-tizer system includes a microphone array 300 which is gener-ally mounted in the operating room on the ceiling or in some other position so that it is in a line of sight with S the surgical probe 302 that is being used. As will be described in greater detail below, the probe 302 includes transmitters such as sound emitters thereon which interact with the microphone array 300 so that the position of the tip of surgical probe 302 is known at any particular instant in time. The 3D digitizer system also includes.a tempera-ture compensation emitter 304 associated with the micro-phone array 300. Furthermore, mounted to the ring 120 (Figure 1C) affixed to the patient's head is a base ring 306 which is coaxial and parallel with the plane defined by reference ring 120. This base ring 306 includes a plural-ity of transmitters as will be described below which inter-act with the microphone array 300 so that the relative posi-tion of the base ring 306 can be determined any particular instant in time. Signal generator 308 generates a signal which is provided through a multiplexer 310 to the temperature compensation emitter 304, surgical probe 302, and base ring 306. Usually, temperature compensation emitter 304 is activated by the signal generator 308 via multiplexer 310 to emit a signal which is received by the microphone array 300. Each of the signals received by each of the microphones of the array 300 is provided to a digitizer 312 which digitizes the signals and provides the digitized signals to computer 314 which includes a spatial acquisition and recording (SAR) program 316 which acquires and records spatial coordinates based on the digitized signals. For example, program 316 may be the SACDAC
program licensed by PIXSYS of Boulder, Colorado. This program evaluates the digitized signals emitted by the temperature compensation emitter 304 to determine the reference standards. i.e., the velocity of the radiation through the air. For example, depending on the temperature of the air in the operating room, the period of time that it takes from the instant that the temperature compensation emitter 304 is actuated to radiate a signal until the instant that each of the microphones of the array 300 receives the emitted signal will vary. The SAR program 316 knows, through calibration, the distance between the tem-perature compensation emitter 304 and each of the micro-phones of the array 300. Therefore, the SAR program 316 can imme~3iately calculate the velocity of the signals being transmitted. This velocity establishes a reference for determining the position of the surgical probe 302 and the base ring 306.
Next, the emitters of the base ring 306 are activated so that the position of the base ring 306 can be determined. At this point, the emitters of the base ring 306 are successively energized and the radiation transmit-ted by these emitters is detected by the microphone array 300. The signal generated by the microphones from this radiation is digitized and evaluated by the SAR program 316 to determine the position of each of the emitters of the base ring 306. Once the positions of the base ring emit-ters have been determined by the SAR program 316, standard geometrical computations are performed by the SAR program to determine the plane defined by the base ring 306 with respect to the microphone array 300.
Digitizer 312 then signals multiplexer 310 to provide the signal generated by signal generator 308 to the surgical probe 302. At this point, the emitters of the sur-gical probe 302 are successively energized and the radiation transmitted by these emitters is detected by tree microphone z~~~2~~
array 300. The signal generated by the microphones from this radiation is digitized and evaluated by the SAR program 316 to determine the position of each of the emitters of the surgical probe 302. Once the positions of the probe emitters have been determined by the SAR program 316, standard geometrical triangulation is performed by the SAR
program to determine the location of the tip of the surgi-cal probe with respect to the microphone array 300.
Therefore, by using the 3D digitizer system, the position of the base ring 306 and the position of the sur-gical probe 302 relative to the base ring 306 can be deter-mined by the SAR program 316. As noted above, the base ring 306 is mounted to the reference ring 120 (Figure 1C) and is essentially coplanar therewith so that the base ring 306 defines the reference plane RP of the scanned image coordinate system illustrated in Figure 1D.
Computer 314 includes translational software 318 which then translates the coordinates of surgical probe coordinate system illustrated in Figure 2D into the scanned image coordinate system illustrated in Figure 1D. As a result of this translation, computer 314 has now determined the particular scanned image of the preoperative scan on which the tip of the surgical probe 302 would be located.
The system includes a tape drive 320, accessed through a local area network (LAN) 321, in which each of the images of the preoperative scan are stored. The translated coordinates generated by translational software 318 are provided to the stereotactic image display software 322, also resident within computer 314, and identify the par-ticular scanned image which is to be viewed by the surgeon.
The identified image is selected by the stereotactic imag-ing system 324 which recreates the image from the data stored in tape drive 320 and displays it on a high ~~~42~~
resolution display 326. Stereotactic image display software 322 and stereotactic image system 324 may be any off-the-shelf system such as manufactured by Stereotactic Image Systems, Inc. of Salt Lake City, Utah.
Referring to 3B, a perspective illustration of the microphone array 300, temperature compensation emitter 304, surgical probe 302 and base ring 306 are illustrated.
Microphone array 300 includes a plurality of microphones 350, the outputs of which are connected to 3D digitizer 312. Adjacent to the microphone array 300 is a temperature compensating emitter 304 which selectively emits signals used by the SAR program in calibration to determine the velocity of the radiation. For example, in the Scientific Accessories Corporation Model GP-8-3D, a sonic digitizer is used. In this case, the speed of sound being transmitted from the temperature compensation emitter 304 to the micro-phones 350 is calculated by the SAR program to determine the speed at which the sound is being transmitted through the air. Since this system is very accurate and the speed of sound varies fairly significantly with respect to the temperature of the air, the temperature compensation emitter 304 allows the 3D digitizer system to compensate for changes in the air temperature in the operating room.
Surgical probe 302 comprises a bayonet surgical forceps modified to carry at least two sound emitters thereon which are essentially coaxial on axis 362 with the tip of the forceps. The emitters are in line and immediately below the surgeon's line of sight through the forceps so that the line of sight is not blocked. In general, the microphone array 350 is attached to the operating light above the patient's head so that it is in direct line of sight with the forceps as they are being used by the surgeon. The microphones 350 listen to the sound emitted from the sequen-tial energization of the emitters 360 on the forceps. The ~~~ 421 14 SAR software 316 measures the time of transmission from each of the sound emitters 360 on the forceps to the micro-phones 350. By comparing these times, the position of both emitters 360 and, therefore, the tip of the forceps can be calculated by the SAR program 316. ' Base ring 306 is affixed to the reference ring 120 attached to the patient's head and is essentially coplanar with the reference points RP1, RP2 and RP3. Base ring 306 includes a plurality of emitters 370 thereon which are connected to multiplexer 310 and energized by signal generator 308. Each one of these emitters 370 is sequen-tially energized so that the radiation emitter thereby is received by the microphones 350 of array 300. The emitters 370 are preferably positioned 90° apart with the center emitter being located at the anterior of the head. This permits base ring 306 to be mounted around the head so that all three emitters are in line of sight with the array.
The resulting signals are digitized by digitizer 312 so that the SAR program 316 is able to determine the plane in which the emitters 370 are located. This plane essentially defines the reference plane because it is coplanar with the reference points RP1, RP2 and RP3. By determining the posi-tion of the reference plane, translational software 318 is now able to take the coordinate position of the probe 302 and translate it from the surgical probe coordinate system of Figure 2D into the scanned image coordinate system as illustrated in Figure 1D. As a result, the particular scanned image which corresponds to the position of the probe can be identified and displayed for viewing by the surgeon.
The surgical probe 302 is generally a bayonet cauterizing device which has a bundle of wire 364 attached thereto. Therefore, the wires required to connect the ~~'~~ ~ ~a~
emitters 360 to the multipleaer 310 are part of the bundle of wires 369 which connect the forceps to its electrical power source and the surgeon is familiar with handling such forceps connected to a wire bundle. Therefore, there is no 5 inconvenience to the surgeon in using such a probe and the surgeon is familiar with handling such a forceps connected to a wire bundle.
Base ring 306 is one apparatus for determining and positioning the reference points RP1, RP2 and RP3 with 10 respect to the microphone array 300. An advantage of the base ring 306 is that each time the patient's head is moved the base ring 306 is energized to define the reference plane. This allows the surgeon to move the patient's head during surgery. Alternatively, the reference points RP1, 15 RF2 and RP3 can be established by using a reference mode of the 3D digitizer 312. In particular, the tip of probe 302 is positioned on each of the reference points RP1, RP2 and RP3 and actuated to emit a signal to the microphone array 300 so that the position of the tip can be determined at each of these points. This is performed during a reference mode of operation of the 3D digitizer 312 so that the SAR
program 3i6 calculates, at the end of the execution of this mode, the position of the reference points RP1, RP2 and RP3.
This requires that the reference points have to be reestab-lished before the position of the surgical probe is deter-mined to avoid changes in the reference plane due to move-ment of the head. On the ether hand, one advantage of this approach is that the use of the reference ring 120 may be eliminated. In particular, it is possible that the refer-3U eiice pins 122 can be permanently affixed to the skull of the patient. For example, these pins may be radiolucent surgical screws which are embedded in the patient's skull and which have radiopaque tips. These screws would be .. 209425. 16 affixed to the patient's skull before surgery and before the preoperative scanning so the radiopaque tips would pro-vide a constant reference during scanning and throughout the stereotactic surgical procedure. During the actual surgery, the probe would be used to indicate the position of each of the radiopaque tips before the probe position was determined. By eliminating the need for the reference ring 120, other advantages are also achieved. For example, generally the preoperative scanning must be done under anesthetic because the reference ring 120 interferes with intubation. Therefore, intubation must occur before the reference ring is affixed to the skull. By eliminating the need for the reference ring 120 and using surgical screws to identify the reference points RP1, RP2 and RP3. the preoperative scanning can be performed without the need for incubation and the anesthesia accompanying it. In one alternative embodiment, it is contemplated that the emitters 370 may each be separately mounted to a screw or other fixed structure positioned at one of the reference points.
In summary, this process according to the inven-tion is illustrated in Figure 3C and identifies the loca-tion of the tip of the surgical probe 202 for the surgeon.
Initially, the reference plane is determined by energizing the base ring 306 or by positioning the probe 302 at the reference points (as described herein). Next, the surgeon positions the probe in the position desired within the head. The emitters of the probe are then energized so that the probe position is measured and determined in the surgi-cal probe coordinate system (X2,Y2.Z2). Next, the trans-lational software 318 converts the surgical probe coordinate system into the scanned image coordinate system (Xo,Yo,Zo) so that the image corresponding to the probe position can be displayed. ' 1~
Referring to Figure 3D, a perspective illustra-tion of a patient's head 390 in a cradle 392 during the scanning process is shown. As will be described below, optical scanner 380, having emitters 381 thereon, is employed to determine the position of the head 390 relative to a cradle 392 positioned on the head.
Referring to 3E, a perspective illustration of the microphone array 300, temperature compensation emitter 304, surgical probe 302 and optical scanner 380 are illus-trated. Microphone array 300 includes a plurality of micro-phones 350, the outputs of which are connected to 3D digi-tizer 312. The microphone array 300 provides a fixed frame of reference to which the position of probe 302 is measured and to which the position of the head 390, relative to the cradle 392, is measured. As a result. the position of the probe 302 relative to the head 390 at any instant in time can be determined.
Adjacent to the microphone array 300 is a temper-ature compensating emitter 304 which selectively emits signals used by the SAR program in calibration to determine the velocity of the radiation. For example, in the Scientific Accessories Corporation Model GP-8-3D, a sonic digitizer is used. In this case, the speed of sound being transmitted from the temperature compensation emitter 304 to the microphones 350 is calculated by the SAR program to determine the speed at which the sound is being transmitted through the air. Since this system is very accurate and the speed of sound varies fairly significantly with respect to the temperature of the air, the temperature compensation 3U emitter 304 allows the 3D digitizer system to compensate for changes in the air temperature in the operating room.
Surgical probe 302 comprises a bayonet surgical forceps modified to carry at least two sound emitters 360 thereon which are essentially coaxial on axis 362 with the ~~94251 tip of the forceps. The emitters are in line and immedi-ately below the surgeon's line of sight through the forceps so that the line of sight is not blocked. In general, the microphone array 350 is attached to the operating room light above the patient's head so that it is in direct line of sight with the forceps as they are being used by the surgeon. The microphones 350 listen to the sound emitted from the sequential energization of the emitters 360 on the forceps. The SAR software 316 measures the time of trans-mission from each of the sound emitters 360 on the forceps to the microphones 350. By comparing these times, the position of both emitters 360 and, therefore, the tip of the forceps can be calculated by the SAR program 316.
Optical scanner 380 is generally located aver the patient's head 390 and is used during scanning to establish the position of the head 390 relative to the cradle 392 thereby to relate the frame of reference of the cross sectional scans to the forehead 394. Scanner 380 is also used during surgery to establish the position of the head 390 relative to the cradle 392 thereby to relate the frame of reference of the probe 302 to the forehead 394.
During the preoperative scanning process as shown in rigure 3D, when the cross sectional images of the head are created, the patient's head lies temporarily in cradle 392. The cradle includes an arc 393 of radiopaque material so that it appears in at least some of the cross sectional scans. As a result, the arc 393 defines a plane relative to the head 390. During scanning, this plane can be defined as the 0,0,0 plane for convenience. After the head is placed iii the cradle, optical scanner 380 is used to establish the position of the cradle 392 and its attached arc 393 relative to the forehead 394. In particular, the optical scanner 380 scans both the forehead and the arc 393 of the cradle 392 and, via computer 396 employing forehead fitting software 398, determines the position of the arc 393 of the cradle 392 relative to the forehead 394. The forehead fitting software may be any off-the-shelf or custom software which graphs a set of points so that a curve defining the contour of the forehead can be calcu-lated, a curve defining the arc can be calculated, and a curve defining the relative position of the forehead and the arc can be calculated. Since the position of the cross sectional scans relative to the radioopaque arc 393 is known (because the cradle arc defines the 0,0,0 plane) and since the position of the arc 393 of the cradle 392 rela-tive to the forehead 394 is known (because of the scanning by the optical scanner), then the position of the cross sectional scans relative to the forehead is known and can be calculated by translational software 316.
During surgery, a base ring 306 is firmly affixed to the head. The base ring 306 does not have to be posi-tioned in the same location relative to the head as the arc was during the scanning process when the cross sectional images were created. The base ring 306 used during surgery includes emitters 370 which communicate with the array 300 to establish the position of the base ring 306. As a result, the base ring 306 defines a plane relative to the head 390. After affixing the base ring to the head, optical scanner 380 is used prior to or during the surgery to establish the position of the base ring 306 relative to the forehead 394. In particular, the optical scanner 380 scans both the forehead and the base ring 306 and, via computer 396 employing forehead fitting software 398, determines the position of the base ring 306 relative to the forehead 392. Since the position of the probe relative to the base ring is known (because of communication via the array) and since the position of the base ring relative to the fore-head is known (because of the scanning by the optical scanner), then the position of the probe relative to the forehead is known and can be calculated by translational 5 software 316. Since the position of the cross sectional images relative to the forehead is also known (from the preoperative scanning process), the end result is that the position of the probe relative to the cross sectional images is known so that the position of the tip of the probe on 10 the closest cross sectional image can be displayed.
Optical scanner 380 and computer 396 are a standard, off the shelf scanner used to scan an object to determine its three-dimensional shape. For example, a limb scanner such as PIXSYS Optical Scanner used to develop 15 three-dimensional models for artificial limbs may be used.
The scanner 380 emits a laser beam or other optical beam toward the arc 393 and the forehead 394 and receives the light reflected there through an array of linear chip cameras such as CCD (charge coupled device) cameras. By 20 evaluating the position of the reflected light using the camera array, the optical scanner 380, including a computer 396, determines the shape and, thus, the contour of the forehead 394, the shape of the arc 393 of cradle 392 and the relative position of the forehead and the arc 393.
Computer 396 indicates to the translational software 316 of computer 314, which is a part of the system as illustrated in Fig. 3A, the position of the probe 302 relative to the forehead 392. The translational software 316 then coverts this indicated position into the coordinate system of the cross sectional scanned images. As a result, the particu-lar scanned image which corresponds to the position of the probe can be identified and displayed on display 326 (Fig.
3A) for viewing by the surgeon.
The surgical probe 302 is generally a bayonet cauterizing device which has a bundle of wire 364 attached thereto. Therefore, the wires required to connect the emitters 360 to the multiplexer 310 are part of the bundle of wires 364 which connect the forceps to its electrical power source. Surgeons are generally familiar with handling such forceps connected to a wire bundle. Therefore, there is no inconvenience to the surgeon in using such a probe and the surgeon is experienced with handling such a forceps connected to a wire bundle.
One advantage of the optical scanner 380 is that it eliminates the need for a ring or pins to be attached to the patient's head during the preoperative scanning process.
Each time the patient's head is placed in a cradle, the optical scanner 38U can be used to scan the head and cradle to redefine their relative position without the need for any contact. The reference ring (i.e., arc) on the head is, therefore, temporary. By eliminating the need for a permanent reference ring 120 or reference pins RP1-RP3, other advantages are also achieved. For example, generally the preoperative scanning must be done under anesthetic because the reference ring 120 interferes with intubation or it must be done after pins are affixed to the head.
Therefore, intubation must occur before the reference ring is affixed to the skull. By eliminating the need for the permanent reference ring 120 and/or reference pins, and by using the contour of the forehead to define a reference point, the preoperative scanning can be performed without the need for intubation and the anesthesia accompanying it.
In summary, during the preoperative scanning process the patient simply lies in a U-shaped cradle attached to the end of a CT or MRI table. Above the patient's face is an arc providing the reference plane.
All scans are obtained with reference to and preferably parallel to this arc defining the reference or base plane.
The optical scanner relates the forehead contour to this arc so that the relation of the forehead to the scans is known.
In the operating room, the patient's head is again scanned with the optical scanner but this time the arc over the patient's head is base ring 306. The reference emitters attached to the base ring define the operative reference system. Therefore, the forehead is again related to the base ring by the optical scanner to define a new reference system; this time the new reference system is the operating room. The computer then matches the forehead contours obtained in the operating room and the scanning room to relate the two reference systems. In effect, the forehead is a "bridge" between the reference system of the preoperative scanner and the reference system of the operating room.
The cradle does not have to appear in the actual scans. The primary purpose of the cradle is to keep the patient's head from moving so that all scans are obtained with the same relationship to the arc.
Referring to Figure 4, a flow chart of the opera-tion of the translational software 318 is illustrated. Ini-tially, the surgeon locates the probe 302 in the position which is to be determined. (If a base ring 306 is not being used to identify the location of the reference plane, the initial step is for the surgeon to use the reference mode of the 3D digitizer 312 to identify the reference plane by locating the surgical probe tip at several points in the plane.) The system initializes at step 400 so that trans-lational software opens a window menu at step 402 of a 23 ~~~~~~.
multitasking program such as DESQ VIEW distributed by quarterdeck Office Systems of Santa Monica, California.
Such software permits simultaneous execution of multiple software programs. In general, once a program is selected for actuation, it continues to run either in the foreground or in the background until deactuated.
The translational software continues initializing by selecting the stereotactic imaging system and actuating the stereotactic imaging system in the foreground by opening the stereotactic window at step 404. Thereafter, the trans-lational software returns to the window menu at step 406 moving the stereotactic image display software to the back-ground and selects the digitizer window at step 408 to actuate the digitizer in the foreground. The computer is then ready to be actuated by the foot switch.
The surgeon then actuates a foot pedal or other switch which indicates that the system should perform a computation. Actuation of the foot switch is essentially the beginning of the start step 410. Upon actuation, the digitizer energizes calibration by the temperature compen-sation emitter 304 to determine the velocity of the sound waves, energizes the emitters of the base ring 306 to locate the reference plane and energizes the emitters of the surgical probe 302 to locate the position of the t~: of the probe 302. The signals generated by the microphone array are digitized so that the SAR program 316 determines the coordinates of the tip of the surgical probe. At step 412, the translational software 318 selects the coordinates from the SAR program.
Next, the window menu is again accessed at step 414 and the window menu switches to the stereotactic image system software to the foreground at step 416 to specifi-cally control the operation of the stereotactic imaging system 324. At this point, the translational software 318 issues an F1 command to the stereotactic image display soft-ware 32Z which in turn prepares the stereotactic imaging system 324 to accept coordinates. At step 420, the window menu is again selected so that at step 422 the computer switches the digitizer window into the foreground. At step 424, the digitizer window menu is accessed and coordinate translation is selected. At. step 426, the digitizer begins calculating the coordinates and at step 928 the coordinate calculation is ended. The translational software then returns to the digitizer window menu at step 430, switches windows to place the stereotactic image system software in the foreground at 432 to prepare it for receiving the coordinates and again returns to the main window menu at step 434. Finally, the coordinate information is trans-lated, including any necessary manipulation, and trans-ferred to the stereotactic image display software 322 at step 436 which actuates the stereotactic imaging system 324 to select the particular image from the tape drive 320 and display it on high resolution display 326. The stereotactic image display software 322 instructs the stereotactic imaging system 329 to display the image closest to trans-ferred coordinates and to display a cursor on the display 326 at the coordinates which corresponds to the position of the tip of the probe. Thereafter, the computer 314 is in a standby mode until the foot switch of the surgeon is again actuated to execute the translational software beginning with the start step 410.
The translation that occurs in step 436 depends on the position of the surgical probe coordinate system relative to the scanned image coordinate system and the units of measure. In the preferred embodiment, the systems are coaxial and the units of measure are the same so that algebraic adjustment is unnecessary. However, it is con-templated that the coordinates systems may not be coaxial, in which case translation would require arithmetic and/or trigonometric calculations. Also, the sequence, e.g., (XZ, Y2, Z2), in which the coordinates are generated by the digitizer may be different than the sequence, e.g., (Xo, Yo, Zo), in which stereotactic image system software receives coordinates. Therefore, the sequence in which the coordinates are transferred may have to be reordered.
Referring to Figure SA, a system employing an ultrasound localizes is illustrated. Reference character 500 refers to an ultrasound probe which may be used in the operating room to scan the brain. The ultrasound probe 500 includes a plurality of at least three emitters 502 which communicate with the array 300 to define the plane in which the ultrasound probe is scanning. Emitters 502 are ener-gized via line 504 by multiplexes 310 as in the other systems illustrated above. The radiation emitted by emitters 502 is received by array 300 to determine the plane in which the ultrasound probe 500 is positioned. The ultrasound probe is also connected via line 506 to a com-puter which analyzes the ultrasound scanning and provides the analyzed information to a work station 510 which displays the scanned image. Since the array 300 can determine the position of the ultrasound probe 500 at any point in time, via digitizer 312, the particular plane of the image displayed on work station 510 is known. The position of the head of the gatient can be determined by attaching a base ring with emitters to the head, as noted above, or by scanning the forehead with an optical scanner having emitters thereon, as noted below.
For example, such an ultrasound image is illus-trated in Figure 5B. The surgeon can then call up the similar image on the display 326 of the stereotactic imaging system 324 such as illustrated in Figure 5C. Alternatively, computer 508 may be linked to the stereotactic imaging system 324 directly to define the particular image plane illustrated on work station 510 so that display 326 can display the corresponding scanned image. As a result, the image from the ultrasound system, as illustrated on work station 510, is shown on one monitor and may be compared to a cross section to the images obtained either by CT, MRI or PET scanning. The cross section through the three dimen-sional data set as developed by the ultrasound system is determined by a high speed graphics work station, such as manufactured by Silicon Graphics. This allows the interpre-tation of the ultrasound scans as the anatomy from the MRI, CT or PET scans can be seen directly. Furthermore, the ultrasound system allows scanning in the operating room.
Since the brain tissue is elastic and the position of various tissue may change from time to time, use of an ultrasound scan in the operating room permits a more definite localization of various brain tissues.
Alternatively, the system may be used for deter-mining a position of the ultrasound probe relative to a head of a body of a patient. The probe 500 is positioned to scan the head 394 with an array 300 positioned adjacent the probe. At least three emitters 502 permit determina-tion of the position of the ultrasound probe relative to the array. Optical scanner 380, having emitters 381 (Fig.
3D) permit determination of the position of the head rela-tive to the array. Computer 396 translates the position of the ultrasound probe into a coordinate system corresponding to the position of the head.
In view of the above, it will be seen that the several objects of the invention are achieved and other advantageous results attained.
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As various changes could be made in the above constructions without departing from the scope of the invention, it is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpreted as illustrative and not in a limiting sense.
Claims (55)
PROPERTY OR PRIVILEGE IS CLAIMED ARE DEFINED AS FOLLOWS:
1. A system for determining a position of a tip of a surgical probe, which is positioned within the head of a body of a patient, relative to cross-sectional images of the head, wherein said cross-sectional images were obtained during pre-operative scanning and are stored in a memory, and wherein said surgical probe has emitters, said system comprising:
means, positioned physically separate from the surgical probe, for detecting output from the emitters and measuring the position of the tip of the surgical probe relative to the head;
means for translating the position of the tip of the surgical probe relative to the head into a coordinate system corresponding to the cross-sectional images of the head; and means for displaying, on a display screen, an image of the head which corresponds to the measured position of the tip of the surgical probe relative to the head.
means, positioned physically separate from the surgical probe, for detecting output from the emitters and measuring the position of the tip of the surgical probe relative to the head;
means for translating the position of the tip of the surgical probe relative to the head into a coordinate system corresponding to the cross-sectional images of the head; and means for displaying, on a display screen, an image of the head which corresponds to the measured position of the tip of the surgical probe relative to the head.
2. The system of claim 1 wherein the displaying means comprises:
means for displaying an image representing the tip of the probe on the displayed image of the head.
means for displaying an image representing the tip of the probe on the displayed image of the head.
3. The system of claim 1 wherein the head includes reference points and the images of the head include reference images corresponding to the reference points, wherein the measuring means measures the position of the tip of the surgical probe relative to the reference points of the head, and wherein the measuring means further comprises:
means for defining a reference plane with respect to the head; and means for measuring the position of the tip of the surgical probe with respect to the reference plane.
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means for defining a reference plane with respect to the head; and means for measuring the position of the tip of the surgical probe with respect to the reference plane.
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4. The system of claim 3 wherein the means for measuring the position of the tip of the surgical probe comprises:
an array mounted adjacent to and in communication with the surgical probe;
means for measuring the position of the reference plane with respect to the array; and means for measuring the position of the tip of the surgical probe with respect to the array.
an array mounted adjacent to and in communication with the surgical probe;
means for measuring the position of the reference plane with respect to the array; and means for measuring the position of the tip of the surgical probe with respect to the array.
5. The system of claim 4 wherein the means for measuring the position of the reference plane comprises:
a base mounted on the head in a known spatial relationship with the reference points of the head; and means for measuring the position of the base with respect to the array.
a base mounted on the head in a known spatial relationship with the reference points of the head; and means for measuring the position of the base with respect to the array.
6. The system of claim 5 wherein the probe comprises a bayonet forceps having emitters in line with the tip of the forceps and below the surgeon's line of sight when using the forceps.
7. The system of claim 5 wherein the means for measuring the position of the base with respect to the array comprises emitters on the base for communicating with the array to indicate the position of the base.
8. The system of claim 3 wherein the reference points define a reference plane and wherein the coordinate system of the images includes an X-Y plane parallel to the reference plane.
9. The system of claim 3 further comprising radiolucent pins having radiopaque tips located in the head to define the reference points.
10. The system of claim 1 wherein the selecting and displaying means comprises a stereotactic imaging sytem.
11. The system of claim 1 wherein the measuring means comprises means for compensating for temperature changes which affect the operation of the measuring means.
12. The system of claim 1 wherein the measuring means comprises means for displaying on the selected image a cursor representing the tip of the probe.
13. The system of claim 1 wherein the means for measuring comprises a three dimensional digitizer.
14. The system of claim 1 wherein the probe comprises a bayonet forceps having two emitters thereon which are in line with the tip of the forceps and below the line of sight through the forceps.
15. The system of claim 1 wherein the translating means comprises a computer connected between the measuring means and the selecting and displaying means and translational software for controlling the operation of the computer so that coordinates supplied to the computer by the measuring means are converted into corresponding coordinates to be supplied to the selecting and displaying means.
16. The system of claim 1 wherein said head has a contour surface, and wherein the position of the cross sectional images relative to the contour surface of the head is known, said system further comprising:
a cradle for supporting the head; and wherein the measuring means comprises means for determining the position of the tip of the surgical probe relative to the cradle, and means for determining the position of the cradle relative to the contour surface of the head thereby determining the position of the tip of the probe relative to the head.
a cradle for supporting the head; and wherein the measuring means comprises means for determining the position of the tip of the surgical probe relative to the cradle, and means for determining the position of the cradle relative to the contour surface of the head thereby determining the position of the tip of the probe relative to the head.
17. The system of claim 16 wherein the means for determining the position of the tip of the surgical probe relative to the cradle comprises:
an array mounted adjacent to the cradle and the probe;
means for measuring the position of the cradle with respect to the array; and means for measuring the position of the tip of the probe with respect to the array.
an array mounted adjacent to the cradle and the probe;
means for measuring the position of the cradle with respect to the array; and means for measuring the position of the tip of the probe with respect to the array.
18. The system of claim 17 wherein the means for measuring the position of the cradle relative to the contour surface comprises an optical scanner for scanning the surface of the head to determine a contour thereof and for scanning a surface of the cradle and further comprising means for determining the position of the contour of the head relative to the surface of the cradle.
19. The system of claim 18 wherein the probe comprises a bayonet forceps having emitters for communicating with the array, said emitters in line with the tip of the forceps and below the surgeon's line of sight when using the forceps.
20. The system of claim 18 further comprising means for identifying the cross sectional image closest to the probe position.
21. A system for determining a position of a tip of a probe, which is positioned within an object, relative to cross-sectional images of the object, wherein said cross-sectional images were obtained during pre-operative scanning and are stored in a memory, and wherein said probe has emitters, said system comprising:
means, positioned physically separate from the probe, for detecting output from the emitters and measuring the position of the tip of the probe relative to the object;
means for translating the position of the tip of the probe relative to the object into a coordinate system corresponding to the cross-sectional images of the object; and means for displaying, on a display screen, the cross-sectional image of the object which corresponds to the measured position of the tip of the probe.
means, positioned physically separate from the probe, for detecting output from the emitters and measuring the position of the tip of the probe relative to the object;
means for translating the position of the tip of the probe relative to the object into a coordinate system corresponding to the cross-sectional images of the object; and means for displaying, on a display screen, the cross-sectional image of the object which corresponds to the measured position of the tip of the probe.
22. A system for use with a part of a body of patient, said system comprising:
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part, wherein the determining means comprises an array positioned in communication with the ultrasound probe;
first means for determining the position of the ultrasound probe relative to the array;
second means for determining the position of the body part relative to the array; and means for translating the position of the ultrasound probe as determined by the first means into a coordinate system corresponding to the position of the body part as determined by the second means;
means for scanning the body part to create scanned images thereof; and means, responsive to the scanning means, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part.
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part, wherein the determining means comprises an array positioned in communication with the ultrasound probe;
first means for determining the position of the ultrasound probe relative to the array;
second means for determining the position of the body part relative to the array; and means for translating the position of the ultrasound probe as determined by the first means into a coordinate system corresponding to the position of the body part as determined by the second means;
means for scanning the body part to create scanned images thereof; and means, responsive to the scanning means, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part.
23. The system of claim 22 wherein the first means comprises at least three emitters on the ultrasound probe and means for activating the emitters to generate a signal communicated to the array.
24. The system of claim 22 wherein the second means comprises means adapted to be mounted on the body part for generating a signal received by the array to indicate the position of the body part relative to the array.
25. A system for use with a part of a body of patient, said system comprising:
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part;
means for scanning the body part to create scanned images thereof; and means, responsive to the scanning means, for generating a scanned image of the body part corresponding to the determined determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part; and wherein the scanning means is adapted to be used prior to an operation and wherein the ultrasound probe is adapted to be used during the operation.
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part;
means for scanning the body part to create scanned images thereof; and means, responsive to the scanning means, for generating a scanned image of the body part corresponding to the determined determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part; and wherein the scanning means is adapted to be used prior to an operation and wherein the ultrasound probe is adapted to be used during the operation.
26. A system for use with a part of a body of patient, said system comprising:
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part, wherein the determing means comprises:
reference points means having a position in fixed relation to the body part for providing reference points, said scanned images including reference images corresponding to the reference points means;
reference means having a location outside the body for providing a reference;
second means for determining the position of the reference points means of the body part relative to the reference means so that the position of the ultrasound probe relative to the reference points means of the body part is a known position; and means for translating the known position of the ultrasound probe to provide a translated position within a coordinate system corresponding to the scanned images of the body part;
means for scanning the body part to create scanned images thereof;
means, responsive to the scanning means, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part.
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part, wherein the determing means comprises:
reference points means having a position in fixed relation to the body part for providing reference points, said scanned images including reference images corresponding to the reference points means;
reference means having a location outside the body for providing a reference;
second means for determining the position of the reference points means of the body part relative to the reference means so that the position of the ultrasound probe relative to the reference points means of the body part is a known position; and means for translating the known position of the ultrasound probe to provide a translated position within a coordinate system corresponding to the scanned images of the body part;
means for scanning the body part to create scanned images thereof;
means, responsive to the scanning means, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part.
27. The system of claim 26 wherein the second means comprises a base adapted to be mounted on the body part in a position having a fixed relationship with the reference points means of the body and means for measuring the position of the base with respect to the reference means.
28. The system of claim 27 wherein the reference means comprises an array having sensors and wherein the ultrasound probe includes emitters on the probe for communicating with the sensors of the array to indicate a position of the ultrasound probe relative to the array.
29. The system of claim 28 further comprising additional emitters on the base for communicating with the sensors of the array to indicate the position of the base relative to the array.
30. A system for use with a part of a body of a patient which has been scanned by a scanning device to create scanned images of the body part, said system comprising:
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part; and means, responsive to the scanning device, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part.
an ultrasound probe adapted to be positioned adjacent to and scanning the body part;
means, responsive to the ultrasound probe, for generating an ultrasound image of the body part corresponding to the position of the ultrasound probe;
means for determining the position of the ultrasound probe relative to the body part; and means, responsive to the scanning device, for generating a scanned image of the body part corresponding to the determined position of the ultrasound probe relative to the body part whereby the ultrasound image of the body part corresponds to and may be compared with the scanned image of the body part.
31. The system of claim 30 wherein the determining means comprises:
an array positioned in communication with the ultrasound probe;
first means for determining the position of the ultrasound probe relative to the array;
second means for determining the position of the body part relative to the array; and means for translating the position of the ultrasound probe as determined by the first means into a coordinate system corresponding to the position of the body part as determined by the second means.
an array positioned in communication with the ultrasound probe;
first means for determining the position of the ultrasound probe relative to the array;
second means for determining the position of the body part relative to the array; and means for translating the position of the ultrasound probe as determined by the first means into a coordinate system corresponding to the position of the body part as determined by the second means.
32. The system of claim 31 wherein the first means comprises at least three emitters on the ultrasound probe and means for activating the emitters to generate a signal communicated to the array.
33. The system of claim 31 wherein the second means comprises means mounted on the body part for generating a signal received by the array to indicate the position of the body part relative to the array.
34. The system of claim 30 wherein the scanning device comprises a CAT, PET, MRI or MEG scanner
35. The system of claim 30 wherein the scanning device is adapted to be used prior to an operation and wherein the ultrasound probe is adapted to be used during the operation.
36. The system of claim 30 wherein the determining means comprises:
reference points means having a position in fixed relation to the body part for providing reference points, said scanned images including reference images corresponding the reference points means;
reference means having a location outside the body part for providing a reference;
first means for determining the position of the ultrasound probe relative to the reference means;
second means for determining the position of the reference points means of the body part relative to the reference means so that the position of the ultrasound probe relative to the reference points means of the body part is known position; and means for translating the known position of the ultrasound probe to provide a translated position within a coordinate system corresponding to the scanned images of the body part created by the scanning device.
reference points means having a position in fixed relation to the body part for providing reference points, said scanned images including reference images corresponding the reference points means;
reference means having a location outside the body part for providing a reference;
first means for determining the position of the ultrasound probe relative to the reference means;
second means for determining the position of the reference points means of the body part relative to the reference means so that the position of the ultrasound probe relative to the reference points means of the body part is known position; and means for translating the known position of the ultrasound probe to provide a translated position within a coordinate system corresponding to the scanned images of the body part created by the scanning device.
37. The system of claim 36 wherein the second means comprises a base adapted to be mounted on the body part in a position having a fixed relationship with the reference points means of the body and means for measuring the position of the base with respect to the reference means.
38. The system of claim 37 wherein the reference means comprises an array having sensors and wherein the ultrasound probe includes emitters on the probe for communicating with the sensors of the array to indicate a position of the ultrasound probe relative to the array.
39. The system of claim 38 further comprising additional emitters on the base for communicating with the sensors of the array to indicate the position of the base relative to the array.
40. The system of claim 37 wherein the ultrasound probe scans a predefined plane relative to the position of the probe, wherein the ultrasound image corresponds to the portion of the body part in the predefined plane, wherein the determining means determines the position of the predefined plane relative to the body part, and wherein the scanned image generated by the generating means corresponds to the portion of the body part in the predefined plane.
41. A system for providing a display of a scan of a scanning technology, the display showing a cross section of a particular position within the body, said system comprising:
reference points means having a position in relation to the body for providing reference points;
means for generating images of the body, said images including reference images corresponding to the reference points means;
reference means having a position outside the body for providing a reference;
an ultrasound probe having a position and generating an ultrasound image of the body;
first means for determining the position of the ultrasound probe relative to the reference means;
second means for determining the position of the reference points means of the body relative to the reference means so that the position of the ultrasound probe relative to the reference points means of the body is a known position;
means for translating the known position of the ultrasound probe to provide a translated position within a coordinate system corresponding to the images of the body;
and means for displaying an image of the body to provide a displayed image which corresponds to the translated position of the ultrasound probe and for displaying the ultrasound image of the body whereby the display image and the ultrasound image correspond to each other.
reference points means having a position in relation to the body for providing reference points;
means for generating images of the body, said images including reference images corresponding to the reference points means;
reference means having a position outside the body for providing a reference;
an ultrasound probe having a position and generating an ultrasound image of the body;
first means for determining the position of the ultrasound probe relative to the reference means;
second means for determining the position of the reference points means of the body relative to the reference means so that the position of the ultrasound probe relative to the reference points means of the body is a known position;
means for translating the known position of the ultrasound probe to provide a translated position within a coordinate system corresponding to the images of the body;
and means for displaying an image of the body to provide a displayed image which corresponds to the translated position of the ultrasound probe and for displaying the ultrasound image of the body whereby the display image and the ultrasound image correspond to each other.
42. A system for indicating a location within a body of a patient, said system comprising:
reference points means having a position in fixed relation to the body for providing reference points;
means for generating images of the body, said images including reference images corresponding to the reference points means;
reference means having a location outside the body for providing a reference;
a surgical probe including a tip having a position;
first means for determining the position of the tip of the surgical probe relative to the reference means;
second means for determing the position of the reference points means of the body relative to the reference means so that the position of the tip relative to the reference points means of the body is a known position;
means for translating the known position of the tip of the surgical probe to provide a translated position within a coordinate system corresponding to the images of the body; and means for displaying an image of the body to provide a displayed image which corresponds to the translated position of the tip of the surgical probe.
reference points means having a position in fixed relation to the body for providing reference points;
means for generating images of the body, said images including reference images corresponding to the reference points means;
reference means having a location outside the body for providing a reference;
a surgical probe including a tip having a position;
first means for determining the position of the tip of the surgical probe relative to the reference means;
second means for determing the position of the reference points means of the body relative to the reference means so that the position of the tip relative to the reference points means of the body is a known position;
means for translating the known position of the tip of the surgical probe to provide a translated position within a coordinate system corresponding to the images of the body; and means for displaying an image of the body to provide a displayed image which corresponds to the translated position of the tip of the surgical probe.
43. The system of claim 42 wherein the displaying means comprises:
means for displaying an image representing the tip of the probe on the displayed image of the body.
means for displaying an image representing the tip of the probe on the displayed image of the body.
44. The system of claim 43 wherein the second means comprises:
a base adapted to be mounted on the body in a position having a fixed relationship with the reference points means of the body; and means for measuring the position of the base with respect to the reference means.
a base adapted to be mounted on the body in a position having a fixed relationship with the reference points means of the body; and means for measuring the position of the base with respect to the reference means.
45. The system of claim 44 wherein the reference means comprises an array having sensors and wherein the probe comprises a bayonet forceps having emitters in line worth the tip of the forceps and below a surgeon's line of sight when sensors of the array to indicate a position of the probe relative to the array.
46. The system of claim 45 further comprises additional emitters on the base for communicating with the sensors of the array to indicate the position of the base relative to the array.
47. The system of claim 45 further comprising three dimensional digitizer means for digitizing signals generated by the sensors in response to signals from the emitters.
48. The system of claim 42 wherein the translating means comprises a computer connected between the second means and the displaying means and a translational software program for controlling the operation of the computer so that coordinates supplied to the computer by the second means are converted into corresponding coordinates supplied to the displaying means.
49. The system of claim 42 wherein the displaying means comprises an imaging system.
50. The system of claim 42 further comprising means for compensating for temperature changes which affect the operation of the first and second determining means.
51. The system of claim 42 wherein the displaying means comprises means for displaying a cursor representing the tip of the probe on the displayed image of the body.
52. The system of claim 42 wherein the reference points define a reference plane and wherein the coordinate system of the images include an X-Y plane parallel to the reference plane.
53. The system of claim 42 wherein the reference means comprises an array having sensors and wherein the probe comprises a bayonet forceps having a line of sight through the forceps and having two emitters mounted on the forceps which are in line with the tip of the forceps and below the line of sight through the forceps, said emitters for communicating with the sensors of the array to indicate the position of the probe relative to the array.
54. The system of claim 42 further comprising radiolucent pins having radiopaque tips, said pins adapted to be located on the body so that said tips define the reference points means.
55. A system for indicating a position within an object, said system comprising:
reference points means having a position in fixed relation to the object for providing reference points;
means for generating images of the object, said images including reference images corresponding to the reference points means;
reference means having a location outside the object for providing a reference;
a probe including a tip having a position;
first means for determining the position of the tip of the probe relative to the reference means;
second means for measuring the position of the reference points means of the object relative to the reference means so that the position of the tip relative reference points means of the object is a known position;
means for translating the known position to the tip of the probe to provide a translated position within a coordinate system corresponding to the images of the object; and means for displaying an image of the object which corresponds to the translated position of the tip of the probe.
reference points means having a position in fixed relation to the object for providing reference points;
means for generating images of the object, said images including reference images corresponding to the reference points means;
reference means having a location outside the object for providing a reference;
a probe including a tip having a position;
first means for determining the position of the tip of the probe relative to the reference means;
second means for measuring the position of the reference points means of the object relative to the reference means so that the position of the tip relative reference points means of the object is a known position;
means for translating the known position to the tip of the probe to provide a translated position within a coordinate system corresponding to the images of the object; and means for displaying an image of the object which corresponds to the translated position of the tip of the probe.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US60075390A | 1990-10-19 | 1990-10-19 | |
US600,753 | 1990-10-19 |
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CA2094251A1 CA2094251A1 (en) | 1992-04-20 |
CA2094251C true CA2094251C (en) | 1999-01-19 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002094251A Expired - Lifetime CA2094251C (en) | 1990-10-19 | 1991-10-17 | Surgical probe locating system for head use |
Country Status (8)
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US (4) | US5383454B1 (en) |
EP (4) | EP0553246B1 (en) |
AT (2) | ATE405223T1 (en) |
AU (1) | AU8876391A (en) |
CA (1) | CA2094251C (en) |
DE (5) | DE69133548T2 (en) |
SE (1) | SE9301262L (en) |
WO (1) | WO1992006645A1 (en) |
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- 1991-10-17 EP EP02004099A patent/EP1210916B1/en not_active Expired - Lifetime
- 1991-10-17 EP EP06100735A patent/EP1690511B1/en not_active Expired - Lifetime
- 1991-10-17 DE DE69133548T patent/DE69133548T2/en not_active Expired - Lifetime
- 1991-10-17 DE DE69133603T patent/DE69133603D1/en not_active Expired - Lifetime
- 1991-10-17 DE DE9117261U patent/DE9117261U1/en not_active Expired - Lifetime
- 1991-10-17 AT AT99108026T patent/ATE405223T1/en not_active IP Right Cessation
- 1991-10-17 DE DE69132412T patent/DE69132412T2/en not_active Expired - Lifetime
- 1991-10-17 DE DE69133634T patent/DE69133634D1/en not_active Expired - Lifetime
- 1991-10-17 CA CA002094251A patent/CA2094251C/en not_active Expired - Lifetime
- 1991-10-17 AT AT91919611T patent/ATE196234T1/en not_active IP Right Cessation
- 1991-10-17 AU AU88763/91A patent/AU8876391A/en not_active Abandoned
- 1991-10-17 EP EP99108026A patent/EP0931516B1/en not_active Expired - Lifetime
-
1992
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-
1993
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-
1995
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-
1998
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-
2002
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ATE196234T1 (en) | 2000-09-15 |
EP0553246A1 (en) | 1993-08-04 |
EP1690511A1 (en) | 2006-08-16 |
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US5383454A (en) | 1995-01-24 |
EP1210916A2 (en) | 2002-06-05 |
AU8876391A (en) | 1992-05-20 |
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CA2094251A1 (en) | 1992-04-20 |
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DE69133548D1 (en) | 2006-11-02 |
ATE405223T1 (en) | 2008-09-15 |
DE9117261U1 (en) | 1998-08-06 |
WO1992006645A1 (en) | 1992-04-30 |
EP1690511B1 (en) | 2010-07-14 |
US6678545B2 (en) | 2004-01-13 |
EP0553246A4 (en) | 1994-08-31 |
EP1210916B1 (en) | 2006-09-20 |
EP0931516B1 (en) | 2008-08-20 |
US5383454B1 (en) | 1996-12-31 |
SE9301262L (en) | 1993-06-18 |
DE69132412T2 (en) | 2001-03-01 |
US6463319B1 (en) | 2002-10-08 |
SE9301262D0 (en) | 1993-04-16 |
EP0931516A1 (en) | 1999-07-28 |
DE69133634D1 (en) | 2010-08-26 |
US20020183615A1 (en) | 2002-12-05 |
DE69132412D1 (en) | 2000-10-19 |
EP1210916A3 (en) | 2002-06-12 |
DE69133603D1 (en) | 2008-10-02 |
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