CA2096109A1 - Tissue factor based prothrombin time reagent - Google Patents

Tissue factor based prothrombin time reagent

Info

Publication number
CA2096109A1
CA2096109A1 CA002096109A CA2096109A CA2096109A1 CA 2096109 A1 CA2096109 A1 CA 2096109A1 CA 002096109 A CA002096109 A CA 002096109A CA 2096109 A CA2096109 A CA 2096109A CA 2096109 A1 CA2096109 A1 CA 2096109A1
Authority
CA
Canada
Prior art keywords
tissue factor
prothrombin time
factor based
time reagent
based prothrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002096109A
Other languages
French (fr)
Other versions
CA2096109C (en
Inventor
Scott M. Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dendreon Pharmaceuticals LLC
Original Assignee
Scott M. Brown
Corvas International, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27086686&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2096109(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Scott M. Brown, Corvas International, Inc. filed Critical Scott M. Brown
Publication of CA2096109A1 publication Critical patent/CA2096109A1/en
Application granted granted Critical
Publication of CA2096109C publication Critical patent/CA2096109C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/5432—Liposomes or microcapsules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2405/00—Assays, e.g. immunoassays or enzyme assays, involving lipids
    • G01N2405/04—Phospholipids, i.e. phosphoglycerides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]

Abstract

Prothrombin time reagents are provided which comprise novel liposome compositions in which tissue factor is associated with and inserted into the phospholipid bilayer of the liposomes. Methods for their preparation are also provided. The liposome compositions may be adjusted to allow maximum coagulant activity and sensitivity to extrinsic coagulation factors.
CA002096109A 1990-11-13 1991-11-04 Tissue factor based prothrombin time reagent Expired - Lifetime CA2096109C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US61211890A 1990-11-13 1990-11-13
US612,118 1990-11-13
US07/784,326 US5314695A (en) 1990-11-13 1991-10-29 Tissue factor based prothrombin time reagent
US784,326 1991-10-29
PCT/US1991/008174 WO1992008479A1 (en) 1990-11-13 1991-11-04 Tissue factor based prothrombin time reagent

Publications (2)

Publication Number Publication Date
CA2096109A1 true CA2096109A1 (en) 1992-05-14
CA2096109C CA2096109C (en) 2004-01-06

Family

ID=27086686

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002096109A Expired - Lifetime CA2096109C (en) 1990-11-13 1991-11-04 Tissue factor based prothrombin time reagent

Country Status (18)

Country Link
US (1) US5314695A (en)
EP (1) EP0564495B2 (en)
JP (1) JP3441456B2 (en)
KR (1) KR100196107B1 (en)
AT (1) ATE179608T1 (en)
AU (2) AU9090791A (en)
CA (1) CA2096109C (en)
DE (1) DE69131204T3 (en)
DK (1) DK0564495T4 (en)
ES (1) ES2133310T5 (en)
FI (1) FI109764B (en)
GR (1) GR3030906T3 (en)
IE (1) IE913955A1 (en)
MX (1) MX9102042A (en)
NO (1) NO314617B1 (en)
NZ (2) NZ240577A (en)
PT (1) PT99499B (en)
WO (1) WO1992008479A1 (en)

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JP3416778B2 (en) * 1991-10-04 2003-06-16 デイド、ベーリング、インコーポレイテッド Production of prothrombin time reagent from recombinant human tissue factor and purified natural and synthetic phospholipids
US6036955A (en) * 1992-03-05 2000-03-14 The Scripps Research Institute Kits and methods for the specific coagulation of vasculature
US6749853B1 (en) * 1992-03-05 2004-06-15 Board Of Regents, The University Of Texas System Combined methods and compositions for coagulation and tumor treatment
US6093399A (en) * 1992-03-05 2000-07-25 Board Of Regents, The University Of Texas System Methods and compositions for the specific coagulation of vasculature
US5877289A (en) * 1992-03-05 1999-03-02 The Scripps Research Institute Tissue factor compositions and ligands for the specific coagulation of vasculature
AU674139B2 (en) * 1992-04-13 1996-12-12 Ortho Diagnostic Systems Inc. Synthetic phospholipid reagent
DK0570356T3 (en) * 1992-05-15 1999-09-20 Immuno Ag Reagent for Determination of Activated Partial Thromboplastin Time (APTT)
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PT988056E (en) * 1997-01-22 2003-09-30 Univ Texas METHODS AND COMPOSITIONS OF A TUMOR FACTOR FOR THE TREATMENT OF COAGULATION AND TUMORS
DE69832628T2 (en) * 1997-04-23 2006-09-07 Instrumentation Laboratory S.P.A. RECOMBINANT RABBIT FACTOR BASED PROTHROMBIN TIME REAGENT
DE19720853A1 (en) * 1997-05-17 1998-11-19 Dade Behring Marburg Gmbh Increasing the FVII sensitivity of a thromboplastin reagent
US6891082B2 (en) 1997-08-01 2005-05-10 The Johns Hopkins University School Of Medicine Transgenic non-human animals expressing a truncated activintype II receptor
US6656475B1 (en) 1997-08-01 2003-12-02 The Johns Hopkins University School Of Medicine Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same
US6245573B1 (en) 1998-02-12 2001-06-12 University Of Medicine And Dentistry Of New Jersey Rapid assessment of the coagulant activity of blood
DE19811016A1 (en) * 1998-03-13 1999-09-16 Dade Behring Marburg Gmbh Ready-to-use prothrombin time reagent based on recombinant tissue factor
US6733985B1 (en) * 1999-05-19 2004-05-11 International Technidyne Corporation Preparation of stable liquid and dried synthetic prothrombin time reagents
US6699718B1 (en) * 1999-09-03 2004-03-02 Roche Diagnostics Corporation Method, reagent and test cartridge for determining clotting time
US6576610B1 (en) 1999-10-04 2003-06-10 Nuvas, Llc Use of a context-dependent functional entity to enhance the efficacy of an agent
US20030147944A1 (en) * 1999-12-10 2003-08-07 Mayer Lawrence D Lipid carrier compositions with protected surface reactive functions
US6248353B1 (en) 1999-12-10 2001-06-19 Dade Behring Inc. Reconstitution of purified membrane proteins into preformed liposomes
US6855509B2 (en) * 2000-12-19 2005-02-15 Instrumentation Laboratory Company Protein S functional assay and kit therefor
US6596543B2 (en) 2001-03-22 2003-07-22 Dade Behring Inc. Use of liposomes of defined composition and size for the preparation of prothrombin time reagents
EP2390308A1 (en) 2002-02-25 2011-11-30 Vaxiion Therapeutics Inc Minicell compositions and methods
AU2003220277A1 (en) * 2002-03-12 2003-09-29 The Johns Hopkins University School Of Medicine Manganese ion regulation of reverse transcriptase activity and methods of modulating same
US20030232075A1 (en) * 2002-05-06 2003-12-18 University Of Minnesota, A Minnesota Corporation Compositions for producing factor Xa
US20040091952A1 (en) * 2002-07-25 2004-05-13 Sysmex Corporation Reagent kit for detecting lupus anticoagulant
US7358337B2 (en) * 2002-08-16 2008-04-15 International Technidyne Corporation Assay for low molecular weight heparin
US7049087B2 (en) * 2002-11-05 2006-05-23 Lifescan, Inc. Method for manufacturing a tissue factor-based prothrombin time reagent
EP1651663B1 (en) * 2003-08-08 2017-05-17 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
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US20050221414A1 (en) * 2004-03-31 2005-10-06 Katalin Varadi Kit for measuring the thrombin generation in a sample of a patient's blood or plasma
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US20080260858A1 (en) * 2005-02-16 2008-10-23 The Board Of Trustees Of The University Of Illnois Universal Procoagulant
AT501650A1 (en) * 2005-02-22 2006-10-15 Technoclone Ges M B H PROCESS FOR DETERMINING COOLING ACTIVATION AND APPARATUS FOR CARRYING OUT SAID METHOD
CN101171034B (en) 2005-03-03 2014-06-18 免疫医疗公司 Humanized L243 antibodies
DE602006021290D1 (en) * 2005-03-04 2011-05-26 Univ Illinois MODULATOR OF COAGULATION CASCADES AND FIBRINOLYTIC CASCADES
JP2007091625A (en) * 2005-09-28 2007-04-12 Shino Test Corp Blood coagulation reaction promoter
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Also Published As

Publication number Publication date
WO1992008479A1 (en) 1992-05-29
MX9102042A (en) 1994-01-31
FI109764B (en) 2002-10-15
NZ240577A (en) 1996-07-26
IE913955A1 (en) 1992-05-20
EP0564495A4 (en) 1994-12-21
NO314617B1 (en) 2003-04-22
FI932148A (en) 1993-06-03
ATE179608T1 (en) 1999-05-15
CA2096109C (en) 2004-01-06
ES2133310T3 (en) 1999-09-16
PT99499B (en) 1999-04-30
EP0564495B1 (en) 1999-05-06
NZ264556A (en) 1996-07-26
EP0564495A1 (en) 1993-10-13
NO931708L (en) 1993-07-08
DE69131204T2 (en) 1999-12-23
JP3441456B2 (en) 2003-09-02
US5314695A (en) 1994-05-24
EP0564495B2 (en) 2006-12-27
GR3030906T3 (en) 1999-11-30
DK0564495T3 (en) 1999-11-15
DE69131204T3 (en) 2007-05-24
NO931708D0 (en) 1993-05-11
AU9090791A (en) 1992-06-11
PT99499A (en) 1992-11-30
AU4448996A (en) 1996-05-09
DE69131204D1 (en) 1999-06-10
ES2133310T5 (en) 2007-08-16
JPH06502649A (en) 1994-03-24
FI932148A0 (en) 1993-05-12
DK0564495T4 (en) 2007-04-30
KR100196107B1 (en) 1999-06-15

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