CA2096532A1 - New human recombinant gamma-interferon - Google Patents

New human recombinant gamma-interferon

Info

Publication number
CA2096532A1
CA2096532A1 CA002096532A CA2096532A CA2096532A1 CA 2096532 A1 CA2096532 A1 CA 2096532A1 CA 002096532 A CA002096532 A CA 002096532A CA 2096532 A CA2096532 A CA 2096532A CA 2096532 A1 CA2096532 A1 CA 2096532A1
Authority
CA
Canada
Prior art keywords
interferon
new
gamma
concerns
human recombinant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002096532A
Other languages
French (fr)
Other versions
CA2096532C (en
Inventor
Otto Slodowski
Joachim Bohm
Bernd Otto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Forderung der Angewandten Forschung eV
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2096532A1 publication Critical patent/CA2096532A1/en
Application granted granted Critical
Publication of CA2096532C publication Critical patent/CA2096532C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention concerns a new mutant of .gamma.-IFN. This new polypep-tide contains 134 amino acids. Amino acids 1 to 132 are the same as those of natural .gamma.-interferon. The first amino acid, methionine, in the zero posi-tion is also present, as has been demonstrated by protein sequencing. The amino acid in position 133 is leucine instead of glutamine. The invention also concerns DNA sequences and plasmid DNA (DSM 6238) which codes for this new polypeptide. The invention further concerns the use of the polypeptide as a drug as well as its use as a fine-chemical reagent for in vitro experiments.
CA002096532A 1990-11-19 1991-11-14 New human recombinant gamma-interferon Expired - Lifetime CA2096532C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4036856A DE4036856C1 (en) 1990-11-19 1990-11-19
DEP4036856.4 1990-11-19
PCT/DE1991/000912 WO1992008737A1 (en) 1990-11-19 1991-11-14 NEW HUMAN RECOMBINANT η INTERFERON

Publications (2)

Publication Number Publication Date
CA2096532A1 true CA2096532A1 (en) 1992-05-20
CA2096532C CA2096532C (en) 2002-12-31

Family

ID=6418557

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002096532A Expired - Lifetime CA2096532C (en) 1990-11-19 1991-11-14 New human recombinant gamma-interferon

Country Status (9)

Country Link
EP (1) EP0652903B1 (en)
JP (1) JP3219274B2 (en)
AT (1) ATE163651T1 (en)
AU (1) AU9026691A (en)
CA (1) CA2096532C (en)
DE (2) DE4036856C1 (en)
DK (1) DK0652903T3 (en)
ES (1) ES2114555T3 (en)
WO (1) WO1992008737A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US7230081B1 (en) 1999-11-12 2007-06-12 Maxygen Holdings, Ltd. Interferon gamma conjugates
US7232562B2 (en) 1999-11-12 2007-06-19 Maxygen Holdings Ltd. E38N interferon gamma polypeptide variants
US7524931B2 (en) 2002-07-03 2009-04-28 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19535853C2 (en) * 1995-09-18 1999-04-01 Fraunhofer Ges Forschung Variants of recombinant human interferon gamma, process for their preparation and their use
DE19604583C2 (en) * 1996-02-08 1999-11-18 Fraunhofer Ges Forschung Process for the synthesis of soluble, recombinant proteins from bacterial cells
IL157896A0 (en) * 2001-04-06 2004-03-28 Maxygen Holdings Ltd Interferon gamma polypeptide variants
JP2022504822A (en) 2018-10-11 2022-01-13 インヒブルクス インコーポレイテッド DLL3 single domain antibody and therapeutic composition thereof
CA3114693A1 (en) 2018-10-11 2020-04-16 Inhibrx, Inc. 5t4 single domain antibodies and therapeutic compositions thereof
US20230124851A1 (en) 2018-10-11 2023-04-20 Inhibrx, lnc. B7h3 single domain antibodies and therapeutic compositions thereof
EP3864049A1 (en) 2018-10-11 2021-08-18 Inhibrx, Inc. Pd-1 single domain antibodies and therapeutic compositions thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855238A (en) * 1983-12-16 1989-08-08 Genentech, Inc. Recombinant gamma interferons having enhanced stability and methods therefor
IL75302A0 (en) * 1984-06-06 1985-09-29 Takeda Chemical Industries Ltd Novel polypeptide and production thereof
JPS6124599A (en) * 1984-07-11 1986-02-03 Kyowa Hakko Kogyo Co Ltd Novel human interferon-gamma polypeptide derivative
GB8619725D0 (en) * 1986-08-13 1986-09-24 Hoffmann La Roche Homogenous interferon fragments
DE3730331A1 (en) * 1987-09-10 1989-03-30 Basf Ag NEW POLYPEPTIDES, METHOD FOR THE PRODUCTION THEREOF, THE VECTORS THEREFOR AND MEDICINAL PRODUCTS THEREOF

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7230081B1 (en) 1999-11-12 2007-06-12 Maxygen Holdings, Ltd. Interferon gamma conjugates
US7232562B2 (en) 1999-11-12 2007-06-19 Maxygen Holdings Ltd. E38N interferon gamma polypeptide variants
US7504237B2 (en) 1999-11-12 2009-03-17 Maxygen Holdings Ltd. Polynucleotides encoding interferon gamma polypeptides
US6958388B2 (en) 2001-04-06 2005-10-25 Maxygen, Aps Interferon gamma polypeptide variants
US7038015B2 (en) 2001-04-06 2006-05-02 Maxygen Holdings, Ltd. Interferon gamma polypeptide variants
US7390638B2 (en) 2001-04-06 2008-06-24 Maxygen Holdings, Ltd. S99T C-11 Truncated polynucleotides encoding interferon gamma polypeptide variants
US7419805B2 (en) 2001-04-06 2008-09-02 Maxygen Holdings, Ltd. Polynucleotides encoding S99T interferon gamma polypeptide variants and means of expression
US7524931B2 (en) 2002-07-03 2009-04-28 Maxygen Holdings Ltd. Full-length interferon gamma polypeptide variants

Also Published As

Publication number Publication date
JPH06502992A (en) 1994-04-07
ES2114555T3 (en) 1998-06-01
AU9026691A (en) 1992-06-11
WO1992008737A1 (en) 1992-05-29
ATE163651T1 (en) 1998-03-15
DK0652903T3 (en) 1998-03-30
JP3219274B2 (en) 2001-10-15
EP0652903B1 (en) 1998-03-04
DE59108947D1 (en) 1998-04-09
EP0652903A1 (en) 1995-05-17
CA2096532C (en) 2002-12-31
DE4036856C1 (en) 1992-05-27

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)

Effective date: 20121202