CA2098196A1 - Method and systems for administering drugs transdermally using sorbitan esters as skin permeation enhancers - Google Patents
Method and systems for administering drugs transdermally using sorbitan esters as skin permeation enhancersInfo
- Publication number
- CA2098196A1 CA2098196A1 CA2098196A CA2098196A CA2098196A1 CA 2098196 A1 CA2098196 A1 CA 2098196A1 CA 2098196 A CA2098196 A CA 2098196A CA 2098196 A CA2098196 A CA 2098196A CA 2098196 A1 CA2098196 A1 CA 2098196A1
- Authority
- CA
- Canada
- Prior art keywords
- systems
- permeation enhancers
- sorbitan esters
- skin permeation
- administering drugs
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940079593 drug Drugs 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title abstract 2
- 239000003623 enhancer Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 title 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 abstract 3
- 239000000006 Nitroglycerin Substances 0.000 abstract 3
- 229960003711 glyceryl trinitrate Drugs 0.000 abstract 3
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
- 230000004907 flux Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003961 penetration enhancing agent Substances 0.000 abstract 1
- -1 sorbitan ester Chemical class 0.000 abstract 1
- 230000037317 transdermal delivery Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
Abstract
Transdermal delivery systems for delivery of nitroglycerin are disclosed which deliver the drug at enhanced transdermal fluxes. The systems include, in addition to nitroglycerin, a permeation enhancer which is either a sorbitan ester, a C8-C22 aliphatic alcohol, or a mixture thereof. Methods for administering nitroglycerin using such permeation enhancers are also disclosed.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/625,906 US5202125A (en) | 1990-12-10 | 1990-12-10 | Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes |
US07/702,043 US5122383A (en) | 1991-05-17 | 1991-05-17 | Sorbitan esters as skin permeation enhancers |
US702,043 | 1991-05-17 | ||
US625,906 | 1991-05-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2098196A1 true CA2098196A1 (en) | 1992-06-10 |
CA2098196C CA2098196C (en) | 1997-01-21 |
Family
ID=27090035
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002098196A Expired - Lifetime CA2098196C (en) | 1990-12-10 | 1991-12-06 | Method and systems for administering drugs transdermally using sorbitan esters as skin permeation enhancers |
Country Status (13)
Country | Link |
---|---|
US (2) | US5202125A (en) |
EP (1) | EP0561983B1 (en) |
JP (1) | JP2604097B2 (en) |
AT (1) | ATE167384T1 (en) |
AU (1) | AU656755B2 (en) |
CA (1) | CA2098196C (en) |
DE (1) | DE69129632T2 (en) |
DK (1) | DK0561983T3 (en) |
ES (1) | ES2117042T3 (en) |
GR (1) | GR3027652T3 (en) |
HK (1) | HK1013790A1 (en) |
PT (1) | PT99749B (en) |
WO (1) | WO1992010154A1 (en) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5762952A (en) * | 1993-04-27 | 1998-06-09 | Hercon Laboratories Corporation | Transdermal delivery of active drugs |
US5613958A (en) * | 1993-05-12 | 1997-03-25 | Pp Holdings Inc. | Transdermal delivery systems for the modulated administration of drugs |
CA2208132A1 (en) * | 1994-12-21 | 1996-06-27 | Theratech, Inc. | Transdermal delivery system with adhesive overlay and peel seal disc |
US20020048596A1 (en) * | 1994-12-30 | 2002-04-25 | Gregor Cevc | Preparation for the transport of an active substance across barriers |
US6024974A (en) * | 1995-01-06 | 2000-02-15 | Noven Pharmaceuticals, Inc. | Composition and methods for transdermal delivery of acid labile drugs |
IL116539A (en) * | 1995-01-06 | 2002-02-10 | Noven Pharma | Compositions for transdermal delivery of acid-labile drugs |
US6929801B2 (en) | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
US6923983B2 (en) | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
US7094422B2 (en) | 1996-02-19 | 2006-08-22 | Acrux Dds Pty Ltd. | Topical delivery of antifungal agents |
AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
US6916487B2 (en) | 1996-02-19 | 2005-07-12 | Acrux Dds Pty Ltd | Transdermal delivery of antiemetics |
US6916486B2 (en) | 1996-02-19 | 2005-07-12 | Acrux Dds Pty Ltd | Transdermal delivery of analgesics |
US6998138B2 (en) | 1996-02-19 | 2006-02-14 | Acrux Dds Pty. Ltd. | Topical delivery of anti-alopecia agents |
GR1002807B (en) * | 1996-06-20 | 1997-11-13 | Lavipharm A.E. | Device for topical treatment of acne and method of manufacture. |
HUP0201299A2 (en) * | 1996-06-20 | 2002-08-28 | Lavipharm Sa | Device for topical treatment of acne and its method of manufacture |
US6440980B1 (en) * | 1996-09-17 | 2002-08-27 | Avanir Pharmaceuticals | Synergistic inhibition of viral replication by long-chain hydrocarbons and nucleoside analogs |
US5952000A (en) * | 1996-10-30 | 1999-09-14 | Theratech, Inc. | Fatty acid esters of lactic acid salts as permeation enhancers |
US7087240B1 (en) | 1998-06-25 | 2006-08-08 | Lavipharm Laboratories Inc. | Device and method for the treatment of erectile dysfunction |
IL140475A0 (en) * | 1998-06-25 | 2002-02-10 | Lavipharm Lab Inc | A device and method for the treatment of erectile dysfunction |
KR20010071049A (en) | 1998-07-29 | 2001-07-28 | 야스이 쇼사꾸 | Pressure-sensitive adhesive composition and moisture-permeable pressure-sensitive adhesive tape, pressure-sensitive adhesive drug composition, and pressure-sensitive adhesive tape preparation each containing the composition |
CA2309633C (en) * | 1998-10-23 | 2010-12-14 | Idea Innovative Dermale Applikationen Gmbh | Method for developing, testing and using associates of macromolecules and complex aggregates for improved payload and controllable de/association rates |
ATE216223T1 (en) | 1999-01-27 | 2002-05-15 | Idea Ag | TRANSNASAL TRANSPORT OR VACCINATION WITH HIGHLY ADAPTABLE CARRIERS |
PT1031346E (en) | 1999-01-27 | 2002-09-30 | Idea Ag | NOT INVASIVE VACCINATION THROUGH SKIN |
DE19925338A1 (en) * | 1999-06-02 | 2000-12-07 | Lohmann Therapie Syst Lts | Substrate sections with increased storage stability during their storage in pouch packaging, and methods for their production |
MXPA02000053A (en) * | 1999-07-05 | 2003-07-21 | Idea Ag | A method for the improvement of transport across adaptable semi-permeable barriers. |
GB9917290D0 (en) * | 1999-07-22 | 1999-09-22 | Glaxo Wellcome Spa | Pharmaceutical composition |
US7083781B2 (en) * | 1999-08-19 | 2006-08-01 | Lavipharm S.A. | Film forming polymers, methods of use, and devices and applications thereof |
GB9930875D0 (en) * | 1999-12-24 | 2000-02-23 | Jehan David | Patch for transdermal therapy |
US6503894B1 (en) | 2000-08-30 | 2003-01-07 | Unimed Pharmaceuticals, Inc. | Pharmaceutical composition and method for treating hypogonadism |
US7473432B2 (en) * | 2002-10-11 | 2009-01-06 | Idea Ag | NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery |
US7105263B2 (en) * | 2003-12-30 | 2006-09-12 | Samsung Electronics Company | Dry toner comprising encapsulated pigment, methods and uses |
US20060008432A1 (en) * | 2004-07-07 | 2006-01-12 | Sebastiano Scarampi | Gilsonite derived pharmaceutical delivery compositions and methods: nail applications |
US20080095722A1 (en) * | 2004-11-12 | 2008-04-24 | Idea Ag | Extended Surface Aggregates in the Treatment of Skin Conditions |
US20060188558A1 (en) * | 2005-02-18 | 2006-08-24 | Mylan Technologies, Inc. | Transdermal systems having control delivery system |
ITMI20050477A1 (en) * | 2005-03-23 | 2006-09-24 | Bouty S P A | TRANSDERMIC PATCH |
DK2450041T3 (en) | 2005-10-12 | 2018-11-19 | Unimed Pharmaceuticals Llc | Enhanced testosterone gel for use in the treatment of hypogonadism |
EP1774964B1 (en) * | 2005-10-13 | 2014-08-06 | Nitto Denko Corporation | Nicotine transdermal preparation and production method thereof |
JP5005277B2 (en) * | 2006-07-13 | 2012-08-22 | 日東電工株式会社 | Patches and patch preparations |
US8796217B2 (en) * | 2008-01-25 | 2014-08-05 | HallStar Italia S.r.l. | Use of transesterified olive oil in the cosmetic field |
US9302085B2 (en) * | 2009-03-11 | 2016-04-05 | The Regents Of The University Of California | Methods and compositions for facilitating arterial access |
DE102010000661A1 (en) * | 2010-01-04 | 2011-07-07 | Acino Ag, 83714 | Method and device for producing an overlapping protective film for a transdermal therapeutic system |
CN113125596B (en) * | 2021-04-07 | 2023-01-13 | 马应龙药业集团股份有限公司 | Method for determining related substances in nitroglycerin ointment by high performance liquid chromatography |
US20230414551A1 (en) * | 2022-06-27 | 2023-12-28 | Permeatus, Inc. | Topical formulations of nitroglycerin |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL61721A (en) * | 1980-12-16 | 1984-03-30 | Blank Izhak | Nitroglycerin preparations |
CA1218604A (en) * | 1981-07-08 | 1987-03-03 | Alec D. Keith | Trinitroglycerol sustained release vehicles and preparations therefrom |
US4559222A (en) * | 1983-05-04 | 1985-12-17 | Alza Corporation | Matrix composition for transdermal therapeutic system |
US4637930A (en) * | 1984-02-08 | 1987-01-20 | Yamanouchi Pharmaceutical Co, Ltd. | Transdermal formulation of nicardipine hydrochloride |
US4879119A (en) * | 1984-02-21 | 1989-11-07 | Yamanouchi Pharmaceutical Co., Ltd. | Patch |
JPS60174716A (en) * | 1984-02-21 | 1985-09-09 | Yamanouchi Pharmaceut Co Ltd | Medicinal patch |
ATE59302T1 (en) * | 1984-07-24 | 1991-01-15 | Key Pharma | ADHESIVE LAYER FOR TRANSDERMAL RELEASE. |
DE3586713T2 (en) * | 1984-11-15 | 1993-05-13 | Hercon Lab | DEVICE FOR THE CONTROLLED DELIVERY OF DRUG ACTIVE SUBSTANCES. |
US4751087A (en) * | 1985-04-19 | 1988-06-14 | Riker Laboratories, Inc. | Transdermal nitroglycerin delivery system |
US4615699A (en) * | 1985-05-03 | 1986-10-07 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
US4690683A (en) * | 1985-07-02 | 1987-09-01 | Rutgers, The State University Of New Jersey | Transdermal varapamil delivery device |
US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
US4764381A (en) * | 1985-12-06 | 1988-08-16 | Key Pharmaceuticals, Inc. | Percutaneous penetration enhancer of oleic acid and 2-ethyl-1, 3-hexanediol |
US4836970A (en) * | 1987-01-30 | 1989-06-06 | Robbins Edward S Iii | Method of extrusion blow-molding container having upper and lower sections of different thickness |
US4983395A (en) * | 1987-11-12 | 1991-01-08 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
US4906475A (en) * | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
US4814168A (en) * | 1988-03-04 | 1989-03-21 | Noven Pharmaceuticals, Inc. | Transdermal multipolymer drug delivery system |
DE69003632T2 (en) * | 1989-02-28 | 1994-02-17 | Teijin Ltd | PLASTER AND THEIR PRODUCTION. |
-
1990
- 1990-12-10 US US07/625,906 patent/US5202125A/en not_active Expired - Lifetime
-
1991
- 1991-12-06 DE DE69129632T patent/DE69129632T2/en not_active Expired - Lifetime
- 1991-12-06 WO PCT/US1991/009215 patent/WO1992010154A1/en active IP Right Grant
- 1991-12-06 DK DK92902108T patent/DK0561983T3/en active
- 1991-12-06 ES ES92902108T patent/ES2117042T3/en not_active Expired - Lifetime
- 1991-12-06 CA CA002098196A patent/CA2098196C/en not_active Expired - Lifetime
- 1991-12-06 AU AU91413/91A patent/AU656755B2/en not_active Ceased
- 1991-12-06 EP EP92902108A patent/EP0561983B1/en not_active Expired - Lifetime
- 1991-12-06 JP JP4502721A patent/JP2604097B2/en not_active Expired - Lifetime
- 1991-12-06 AT AT92902108T patent/ATE167384T1/en not_active IP Right Cessation
- 1991-12-10 PT PT99749A patent/PT99749B/en active IP Right Grant
-
1992
- 1992-07-24 US US07/919,296 patent/US5302395A/en not_active Expired - Lifetime
-
1998
- 1998-08-14 GR GR980401827T patent/GR3027652T3/en unknown
- 1998-12-24 HK HK98115310A patent/HK1013790A1/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE167384T1 (en) | 1998-07-15 |
HK1013790A1 (en) | 1999-09-10 |
DE69129632T2 (en) | 1998-11-05 |
EP0561983A1 (en) | 1993-09-29 |
EP0561983A4 (en) | 1993-10-20 |
US5302395A (en) | 1994-04-12 |
AU9141391A (en) | 1992-07-08 |
DK0561983T3 (en) | 1998-10-19 |
PT99749A (en) | 1993-04-30 |
WO1992010154A1 (en) | 1992-06-25 |
PT99749B (en) | 1999-05-31 |
EP0561983B1 (en) | 1998-06-17 |
JPH06503576A (en) | 1994-04-21 |
DE69129632D1 (en) | 1998-07-23 |
ES2117042T3 (en) | 1998-08-01 |
CA2098196C (en) | 1997-01-21 |
AU656755B2 (en) | 1995-02-16 |
US5202125A (en) | 1993-04-13 |
JP2604097B2 (en) | 1997-04-23 |
GR3027652T3 (en) | 1998-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2098196A1 (en) | Method and systems for administering drugs transdermally using sorbitan esters as skin permeation enhancers | |
AU7396294A (en) | Incorporating poly-n-vinyl amide in a transdermal system | |
MX9709162A (en) | Skin permeation enhancer compositions using acyl lactylates. | |
ES2137261T3 (en) | TRANSDERMIC ADMINISTRATION OF OXYBUTININE. | |
CA2012875A1 (en) | Skin permeation enhancer compositions | |
ES2011185A6 (en) | Skin permeation enhancer compositions using glycerol monooleate | |
EP0279977A3 (en) | Transdermal administration of progesterone, estradiol esters and mixtures thereof | |
DK0934078T3 (en) | Permeability promoters for transdermal administration of active substances, devices and processes for their preparation | |
MY102378A (en) | Transdermal delivery system. | |
MX9401331A (en) | PHARMACEUTICAL COMPOSITION AND USEFUL ARTICLE TO INHIBIT SKIN IRRITATION. | |
AU3601897A (en) | Novel formulations for the administration of fluoxetine | |
ATE284206T1 (en) | TRANSDERMAL ADMINISTERED DEXTROMETHORPHAN AS A COUGH MEDICINE | |
KR930702930A (en) | Methods and systems for the percutaneous administration of medicaments using sorbitan esters as skin penetration enhancers |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |