CA2103052A1 - Assay device - Google Patents

Assay device

Info

Publication number
CA2103052A1
CA2103052A1 CA002103052A CA2103052A CA2103052A1 CA 2103052 A1 CA2103052 A1 CA 2103052A1 CA 002103052 A CA002103052 A CA 002103052A CA 2103052 A CA2103052 A CA 2103052A CA 2103052 A1 CA2103052 A1 CA 2103052A1
Authority
CA
Canada
Prior art keywords
sample
components
devices
opposable
preparation means
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002103052A
Other languages
French (fr)
Other versions
CA2103052C (en
Inventor
Howard M. Chandler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Diagnostics Inc
Original Assignee
Howard M. Chandler
Smithkline Diagnostics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24838456&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2103052(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Howard M. Chandler, Smithkline Diagnostics, Inc. filed Critical Howard M. Chandler
Publication of CA2103052A1 publication Critical patent/CA2103052A1/en
Application granted granted Critical
Publication of CA2103052C publication Critical patent/CA2103052C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B01L3/5055Hinged, e.g. opposable surfaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5023Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures with a sample being transported to, and subsequently stored in an absorbent for analysis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90Plate chromatography, e.g. thin layer or paper chromatography
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/90Plate chromatography, e.g. thin layer or paper chromatography
    • G01N30/91Application of the sample
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302Apparatus specially adapted for immunological test procedures
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54386Analytical elements
    • G01N33/54387Immunochromatographic test strips
    • G01N33/54388Immunochromatographic test strips based on lateral flow
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/558Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0825Test strips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406Moving fluids with specific forces or mechanical means specific forces capillary forces
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/26Conditioning of the fluid carrier; Flow patterns
    • G01N30/28Control of physical parameters of the fluid carrier
    • G01N30/30Control of physical parameters of the fluid carrier of temperature
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/805Test papers
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/81Packaged device or kit
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/97Test strip or test slide
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/807Apparatus included in process claim, e.g. physical support structures
    • Y10S436/81Tube, bottle, or dipstick

Abstract

A chromatographic assay device for use with immunoassays allows rapid and convenient assays of analytes of biological interest, and permits extractions to be carried out in situ, avoiding the use of separate extraction vessels, The device has a wide dynamic range and avoids interference from particulates or colored components.
In one form, the device comprises: (1) a first opposable component (12) comprising a sample preparation means (16) adapted to receive a sample to be assayed; and (2) a second opposable component (14) comprising a chromatographic medium (18). The first and second opposable components can be brought into opposition so as to cause the sample preparation means to apply the sample to be tested to the chromatographic medium. Preferably, the analyte is detected with a visually detectable label.
Other variations of the device vary the arrangement of components to provide optimal chromatography for a variety of analyzes, as well as to permit bi-directional chromatography, The devices can be incorporated in test kits, and assay methods using the devices are also disclosed.
CA002103052A 1991-05-29 1992-05-27 Assay device Expired - Lifetime CA2103052C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/706,639 US6168956B1 (en) 1991-05-29 1991-05-29 Multiple component chromatographic assay device
US706,639 1991-05-29
PCT/US1992/004425 WO1992021977A1 (en) 1991-05-29 1992-05-27 Assay device

Publications (2)

Publication Number Publication Date
CA2103052A1 true CA2103052A1 (en) 1992-11-30
CA2103052C CA2103052C (en) 2005-12-27

Family

ID=24838456

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002103052A Expired - Lifetime CA2103052C (en) 1991-05-29 1992-05-27 Assay device

Country Status (11)

Country Link
US (1) US6168956B1 (en)
EP (3) EP1376130B1 (en)
JP (1) JP3386122B2 (en)
AT (1) ATE174432T1 (en)
AU (1) AU665956B2 (en)
CA (1) CA2103052C (en)
DE (3) DE69233290T2 (en)
DK (1) DK0586595T3 (en)
ES (1) ES2127754T3 (en)
FI (1) FI935244A0 (en)
WO (1) WO1992021977A1 (en)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648274A (en) * 1991-05-29 1997-07-15 Smithkline Diagnostics, Inc. Competitive immunoassay device
US5468648A (en) * 1991-05-29 1995-11-21 Smithkline Diagnostics, Inc. Interrupted-flow assay device
US5869345A (en) * 1991-05-29 1999-02-09 Smithkline Diagnostics, Inc. Opposable-element assay device employing conductive barrier
US5877028A (en) * 1991-05-29 1999-03-02 Smithkline Diagnostics, Inc. Immunochromatographic assay device
US5607863A (en) * 1991-05-29 1997-03-04 Smithkline Diagnostics, Inc. Barrier-controlled assay device
US6007999A (en) * 1991-07-31 1999-12-28 Idexx Laboratories, Inc. Reversible flow chromatographic binding assay
US5726010A (en) * 1991-07-31 1998-03-10 Idexx Laboratories, Inc. Reversible flow chromatographic binding assay
JP3479100B2 (en) * 1993-06-02 2003-12-15 帝国臓器製薬株式会社 Simple semi-quantitative immunochemical method and apparatus
US6319665B1 (en) * 1994-06-07 2001-11-20 Inverness Medical Technology, Inc. Home test kit and method with telephone verification of results
AUPO071396A0 (en) 1996-06-28 1996-07-25 Chandler, Howard Milne Chromatographic assay or test device
AUPP323798A0 (en) 1998-04-28 1998-05-21 Chandler, Howard Milne Sample collection method
US6824997B1 (en) 1998-09-18 2004-11-30 Binax, Inc. Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies
US9134303B1 (en) * 1998-08-25 2015-09-15 Alere Scarborough, Inc. ICT immunoassay for Legionella pneumophila serogroup 1 antigen employing affinity purified antibodies thereto
US6316205B1 (en) * 2000-01-28 2001-11-13 Genelabs Diagnostics Pte Ltd. Assay devices and methods of analyte detection
JP3680090B2 (en) 2000-05-25 2005-08-10 株式会社ニチレイ Analysis equipment
US20040096985A1 (en) * 2001-09-28 2004-05-20 Noriko Kenjyou Specific binding analyzer and method of analyzing specific binding
US7587793B2 (en) * 2001-12-14 2009-09-15 Bode Technology Group, Inc. Evidence collection holder and storage method
US20050048077A1 (en) * 2002-02-21 2005-03-03 George Sachs Compositions, test kits and methods for detecting helicobacter pylori
US20030166027A1 (en) * 2002-02-21 2003-09-04 George Sachs Compositions, test kits and methods for detecting helicobacter pylori
US7883899B2 (en) * 2002-10-11 2011-02-08 Zbx Corporation Diagnostic devices
US20040202571A1 (en) * 2003-04-10 2004-10-14 Epler Gary R. Directed medication system and method
US7393697B2 (en) * 2003-06-06 2008-07-01 Advantage Diagnostics Corporation Diagnostic test for analytes in a sample
US7238538B2 (en) 2003-09-19 2007-07-03 Freitag Helmut E Chromatographic assay device and methods
US7378285B2 (en) 2003-09-22 2008-05-27 Paul Lambotte Devices for the detection of multiple analytes in a sample
AU2005210742B2 (en) * 2004-02-09 2011-06-09 Rapid Pathogen Screening Inc. Method for the rapid diagnosis of targets in human body fluids
US7488450B2 (en) * 2004-03-04 2009-02-10 Beckman Coulter, Inc. Analyte collection and detection devices
GB0412949D0 (en) * 2004-06-10 2004-07-14 Inverness Medical Switzerland Improvements in or relating to lateral flow assay devices
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
US7387890B2 (en) 2004-12-16 2008-06-17 Chembio Diagnostic Systems, Inc. Immunoassay devices and use thereof
WO2006081021A1 (en) * 2005-01-25 2006-08-03 The Bode Technology Group, Inc Evidence collection holder for sample automation
US8445293B2 (en) 2005-02-09 2013-05-21 Rapid Pathogen Screening, Inc. Method to increase specificity and/or accuracy of lateral flow immunoassays
WO2006098804A2 (en) * 2005-03-11 2006-09-21 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
US7189522B2 (en) 2005-03-11 2007-03-13 Chembio Diagnostic Systems, Inc. Dual path immunoassay device
JP4891317B2 (en) * 2005-06-28 2012-03-07 ズィービーエックス・コーポレーション Membrane array and analytical equipment
GB0517447D0 (en) 2005-08-25 2005-10-05 Smart Holograms Ltd Use of holographic sensor
US7871568B2 (en) 2006-01-23 2011-01-18 Quidel Corporation Rapid test apparatus
US7794656B2 (en) 2006-01-23 2010-09-14 Quidel Corporation Device for handling and analysis of a biological sample
KR20090031362A (en) * 2006-05-18 2009-03-25 페터리내르메디찌니쉐 우니버지태트 빈 Detection method for influenza viruses
CA2664698C (en) 2006-09-28 2016-06-07 The Macfarlane Burnet Institute For Medical Research And Public Health Limited A method and kit for evaluating cd4 t-cell numbers
JP5117928B2 (en) * 2008-05-27 2013-01-16 富士フイルム株式会社 Immunochromatographic device
US20100022916A1 (en) 2008-07-24 2010-01-28 Javanbakhsh Esfandiari Method and Apparatus for Collecting and Preparing Biological Samples for Testing
US8956859B1 (en) 2010-08-13 2015-02-17 Aviex Technologies Llc Compositions and methods for determining successful immunization by one or more vaccines
US8603835B2 (en) 2011-02-10 2013-12-10 Chembio Diagnostic Systems, Inc. Reduced step dual path immunoassay device and method
US20140295472A1 (en) * 2011-11-10 2014-10-02 The Administrators Of The Tulane Educational Fund Paper Based Diagnostic Test
US10416158B2 (en) 2014-03-11 2019-09-17 Wisconsin Alumni Research Foundation Peptide MHCII tetramers to detect endogenous calnexin specific CD4 T cells
CN106574223B (en) 2014-04-02 2019-11-01 生化诊断系统公司 Utilize the immunoassays of capture conjugate
JP6357616B2 (en) * 2014-10-02 2018-07-18 アドテック株式会社 Sheet immunoassay
US20160116466A1 (en) 2014-10-27 2016-04-28 Chembio Diagnostic Systems, Inc. Rapid Screening Assay for Qualitative Detection of Multiple Febrile Illnesses
USD806891S1 (en) * 2016-01-11 2018-01-02 Mi & Mi Technologies, Llc Diagnostic card
CN110720033A (en) * 2016-12-08 2020-01-21 Essenlix 公司 Analytical sample card and adapter and use thereof
CN108344733B (en) * 2017-01-25 2020-05-01 吴智良 Occult blood test paper
CN109115753A (en) * 2017-06-22 2019-01-01 吴智良 Occult blood test device and method
CN109187962A (en) * 2017-10-07 2019-01-11 贾晓轻 Blood sample immunochromatography diagnosis test paper, kit and detection method
CN107764988B (en) * 2017-10-21 2019-07-05 深圳市艾伟迪生物科技有限公司 Clinical sample immunochromatography diagnosis test paper, kit and diagnostic method
WO2023064185A1 (en) * 2021-10-15 2023-04-20 Idexx Laboratories, Inc. Homogenous enzyme linked immunoassay

Family Cites Families (401)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US1926299A (en) 1932-11-04 1933-09-12 Nelson Knitting Company Carton
US3078031A (en) 1961-07-18 1963-02-19 Foils Packaging Corp Reclosure lock
US3186623A (en) 1961-09-05 1965-06-01 Waldorf Paper Prod Co Carton tear strip opener
NL125235C (en) 1965-04-15
US3307770A (en) 1965-07-26 1967-03-07 Waldorf Paper Prod Co Butter cartons and the like
US3420205A (en) 1966-03-23 1969-01-07 Miles Lab Indicating device
US3437449A (en) 1966-06-08 1969-04-08 Manley J Luckey Breath alcohol determination
GB979193A (en) 1966-10-19 1965-01-01 Konstantin Sergeevich Evstropi Optical glasses
US3720760A (en) 1968-09-06 1973-03-13 Pharmacia Ab Method for determining the presence of reagin-immunoglobulins(reagin-ig)directed against certain allergens,in aqueous samples
USRE31006E (en) 1968-09-24 1982-08-03 Akzona Incorporated Process for the demonstration and determination of reaction components having specific binding affinity for each other
US3811840A (en) 1969-04-01 1974-05-21 Miles Lab Test device for detecting low concentrations of substances in fluids
US3993451A (en) 1970-07-28 1976-11-23 Miles Laboratories, Inc. Test for a given constituent in a liquid
US3932220A (en) 1970-08-11 1976-01-13 Liotta Lance A Method for isolating bacterial colonies
US4067774A (en) 1971-05-14 1978-01-10 Syva Company Compounds for enzyme amplification assay
US3723064A (en) 1971-07-26 1973-03-27 L Liotta Method and device for determining the concentration of a material in a liquid
CA983358A (en) 1971-09-08 1976-02-10 Kenneth D. Bagshawe Performance of chemical or biological reactions
US3902964A (en) 1971-12-13 1975-09-02 U S Medical Research And Dev I Method of and apparatus for chemically separating plasma or serum from formed elements of blood
US3867517A (en) 1971-12-21 1975-02-18 Abbott Lab Direct radioimmunoassay for antigens and their antibodies
US3798004A (en) 1972-04-18 1974-03-19 Ames Yissum Ltd Test device
US4054646A (en) 1973-07-30 1977-10-18 General Electric Method and apparatus for detection of antibodies and antigens
US4012198A (en) 1972-07-25 1977-03-15 Burroughs Wellcome Co. Immunodiffusion device
US3989591A (en) 1973-01-15 1976-11-02 Liotta Lance A Test method for separating and/or isolating bacteria and tissue cells
FI49086C (en) 1973-01-25 1975-03-10 Matti Antero Reunanen Radioimmunoassay.
US3966897A (en) 1973-04-02 1976-06-29 Marine Colloids, Inc. Medium for use in bioassay and method of using same
IL42105A (en) 1973-04-25 1976-08-31 Yissum Res Dev Co Process for determination of triiodothyronine
CA1023251A (en) 1973-06-22 1977-12-27 The Standard Oil Company Method and paper test strip for determining low levels of lead in hydrocarbon fuels
US4039652A (en) 1973-10-11 1977-08-02 Miles Laboratories, Inc. Column method of immunoassay employing an immobilized binding partner
US3949064A (en) 1973-10-26 1976-04-06 Baxter Laboratories, Inc. Method of detecting antigens or antibodies
US3935074A (en) 1973-12-17 1976-01-27 Syva Company Antibody steric hindrance immunoassay with two antibodies
GB1451669A (en) 1974-01-02 1976-10-06 Radiochemical Centre Ltd Protein staining
US3926564A (en) 1974-02-25 1975-12-16 Gen Electric Substrate for immunological tests and method of fabrication thereof
US3933997A (en) 1974-03-01 1976-01-20 Corning Glass Works Solid phase radioimmunoassay of digoxin
US3975162A (en) 1974-03-13 1976-08-17 Marine Colloids, Inc. Applying reagent to medium and device therefor
US4108972A (en) 1974-03-15 1978-08-22 Dreyer William J Immunological reagent employing radioactive and other tracers
US3901657A (en) 1974-04-29 1975-08-26 Sun Scient Inc Device for testing solutions and body fluids
US4169138A (en) 1974-05-29 1979-09-25 Pharmacia Diagnostics Ab Method for the detection of antibodies
US3951332A (en) 1974-07-22 1976-04-20 Torbeck Frank W Container closure with tuck-under tab
US3933594A (en) 1974-08-16 1976-01-20 Polaroid Corporation Method and device for determining the concentration of a substance in a fluid
US3915647A (en) 1974-08-16 1975-10-28 Polaroid Corp Device for determining the concentration of a substance in a fluid
US3979509A (en) 1974-09-03 1976-09-07 General Electric Company Opaque layer method for detecting biological particles
US4017597A (en) 1974-10-30 1977-04-12 Monsanto Company Unitized solid phase immunoassay kit and method
US4123509A (en) 1974-12-19 1978-10-31 American Home Products Corporation Pregnancy test
US4018662A (en) 1975-01-03 1977-04-19 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. Method and apparatus for simultaneous quantitative analysis of several constituents in a sample
SE388694B (en) 1975-01-27 1976-10-11 Kabi Ab WAY TO PROVIDE AN ANTIGEN EXV IN SAMPLES OF BODY WHEATS, USING POROST BERAR MATERIAL BONDED OR ADSORBING ANTIBODIES
US3960499A (en) 1975-02-18 1976-06-01 Miles Laboratories, Inc. Biological test apparatus
US3992631A (en) 1975-02-27 1976-11-16 International Diagnostic Technology, Inc. Fluorometric system, method and test article
DE2513103C3 (en) 1975-03-25 1980-08-28 Industrias Figueras S.A., Barcelona (Spanien) Chair with a folding seat
US4180383A (en) 1975-04-07 1979-12-25 Becton, Dickinson And Company Chamber holder for immobilized immunoadsorbent
US4166102A (en) 1975-04-07 1979-08-28 Becton, Dickinson And Company Immobilized immunoadsorbent
NO136062C (en) 1975-04-14 1977-07-13 Henry Hirschberg PROCEDURE AND DEVICE FOR COLLECTING LIQUID CONTAINING RADIOACTIVE TRACTORS.
CA1054034A (en) 1975-06-20 1979-05-08 Barbara J. Bruschi Multilayer analytical element
USRE30267E (en) 1975-06-20 1980-05-06 Eastman Kodak Company Multilayer analytical element
US4042335A (en) 1975-07-23 1977-08-16 Eastman Kodak Company Integral element for analysis of liquids
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
US4474878A (en) 1975-09-29 1984-10-02 Cordis Laboratories, Inc. Sandwich EIA for antigen associated with hepatitis
US4642285A (en) 1975-09-29 1987-02-10 Diamedix Corporation Sandwich EIA for antigen
US3984533A (en) 1975-11-13 1976-10-05 General Electric Company Electrophoretic method of detecting antigen-antibody reaction
US4123224A (en) 1975-12-17 1978-10-31 American Home Products Corporation Diagnostic test device
US3990850A (en) 1976-01-06 1976-11-09 Akzona Incorporated Diagnostic test card
US4020151A (en) 1976-02-17 1977-04-26 International Diagnostic Technology, Inc. Method for quantitation of antigens or antibodies on a solid surface
US4053284A (en) 1976-03-10 1977-10-11 Akzona Incorporated Continuous flow apparatus for biological testing
US4128399A (en) 1976-03-15 1978-12-05 Liotta Lance A Device and method for detecting phenothiazine-type drugs in urine
US4038485A (en) 1976-03-18 1977-07-26 Miles Laboratories, Inc. Test composition, device, and method
US4059407A (en) 1976-04-14 1977-11-22 Becton, Dickinson And Company Disposable chemical indicators
US4087326A (en) 1976-05-03 1978-05-02 Ethicon, Inc. Microbiological scaled sterility test strips and method
US4087332A (en) 1976-05-07 1978-05-02 Kai Aage Hansen Indicator for use in selection of bactericidal and bacteristatic drugs and method for producing same
US4067959A (en) 1976-05-10 1978-01-10 International Diagnostic Technology, Inc. Indirect solid surface test for antigens or antibodies
IL49685A (en) 1976-05-31 1978-10-31 Technion Res & Dev Foundation Specific binding assay method for determining the concentration of materials and reagent means therefor
US4157323A (en) 1976-06-09 1979-06-05 California Institute Of Technology Metal containing polymeric functional microspheres
US4094647A (en) 1976-07-02 1978-06-13 Thyroid Diagnostics, Inc. Test device
GB1582956A (en) 1976-07-30 1981-01-21 Ici Ltd Composite magnetic particles
US4210418A (en) 1976-08-30 1980-07-01 Mallinckrodt, Inc. Container for immunochemical and enzymatical determinations or procedures
US4145186A (en) 1976-10-04 1979-03-20 H. W. Andersen Products Inc. Sterilization detection device and method
GB1572220A (en) 1976-10-07 1980-07-30 Mochida Pharm Co Ltd Immunochemical process of measuring physiologically active substances
US4046514A (en) 1976-11-24 1977-09-06 Miles Laboratories, Inc. Test device and method for determining a component in a sample
US4134792A (en) 1976-12-06 1979-01-16 Miles Laboratories, Inc. Specific binding assay with an enzyme modulator as a labeling substance
US4407943A (en) 1976-12-16 1983-10-04 Millipore Corporation Immobilized antibody or antigen for immunoassay
US4200690A (en) 1976-12-16 1980-04-29 Millipore Corporation Immunoassay with membrane immobilized antibody
US4130462A (en) 1976-12-16 1978-12-19 Syva Company Receptor steric hindrance immunoassay for receptor determination
CA1095819A (en) 1977-01-14 1981-02-17 Eastman Kodak Company Element for analysis of liquids
IL51354A (en) 1977-01-28 1979-07-25 Ames Yissum Ltd Assay method for the quantitative determination of a hapten in aqueous solution
US4116638A (en) 1977-03-03 1978-09-26 Warner-Lambert Company Immunoassay device
US4108976A (en) 1977-03-04 1978-08-22 Becton, Dickinson And Company Automated direct serum radioimmunoassay
IL51667A (en) 1977-03-16 1979-10-31 Miles Yeda Ltd Immunoassay for the determination of a hapten
US4145406A (en) 1977-04-11 1979-03-20 Miles Laboratories, Inc. Specific binding - adsorbent assay method and test means
US4108729A (en) 1977-05-16 1978-08-22 U.S. Packaging Corp. Paper booklet for presumptive diagnosis of Neisseria Gonorrhoeae in the male
US4110079A (en) 1977-06-09 1978-08-29 Eastman Kodak Company Analytical element for clinical analysis
US4411518A (en) 1977-09-23 1983-10-25 Gamma Biologicals, Inc. Apparatus for use in qualitative determination of immunological reactions
US4129417A (en) 1977-10-28 1978-12-12 Miles Laboratories, Inc. Multisystem test means
US4219335A (en) 1978-09-18 1980-08-26 E. I. Du Pont De Nemours And Company Immunochemical testing using tagged reagents
US4298345A (en) 1977-11-21 1981-11-03 Damon Corporation Method and apparatus for chemical spot test analysis
US4153668A (en) 1978-01-03 1979-05-08 Eastman Kodak Company Multi-zone analytical element and method using same
US4160008A (en) 1978-01-26 1979-07-03 Miles Laboratories, Inc. Multilayered test device for determining the presence of a liquid sample component, and method of use
US4244694A (en) 1978-03-31 1981-01-13 Union Carbide Corporation Reactor/separator device for use in automated solid phase immunoassay
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4380580A (en) 1978-04-10 1983-04-19 Miles Laboratories, Inc. Heterogenous chemiluminescent specific binding assay
US4631174A (en) 1978-05-02 1986-12-23 Fuji Photo Film Co., Ltd. Multilayer chemical analysis member having an outer waterproof layer
JPS5510590A (en) 1978-05-04 1980-01-25 Wellcome Found Enzyme immunity quantity analysis
DE2821469A1 (en) 1978-05-17 1979-11-22 Boehringer Mannheim Gmbh DIAGNOSTIC AGENT FOR DETERMINING UREA
NZ190452A (en) 1978-05-19 1981-04-24 Becton Dickinson Co Solid phase assay receptor contacted with analyte and then with labeled analyte
JPS587332Y2 (en) 1978-06-06 1983-02-08 富士写真フイルム株式会社 Multilayer blood chemistry analysis material
US4254082A (en) 1978-06-12 1981-03-03 Miles Laboratories, Inc. Specific binding-adsorbent assay test means
US4238565A (en) 1978-06-22 1980-12-09 Miles Laboratories, Inc. Specific binding assay with a prosthetic group as a label component
US4175923A (en) 1978-06-26 1979-11-27 Friend William G Method and apparatus for occult blood testing in the home
NL7807532A (en) 1978-07-13 1980-01-15 Akzo Nv METAL IMMUNO TEST.
DE2932973A1 (en) 1978-08-14 1980-02-28 Fuji Photo Film Co Ltd INTEGRAL MULTILAYERED MATERIAL FOR CHEMICAL ANALYSIS OF BLOOD
DE2836046A1 (en) 1978-08-17 1980-02-28 Behringwerke Ag IMMUNOLOGICAL DETERMINATION PROCEDURE
US4228237A (en) 1978-09-21 1980-10-14 Calbiochem-Behring Corp. Methods for the detection and determination of ligands
US4254083A (en) 1979-07-23 1981-03-03 Eastman Kodak Company Structural configuration for transport of a liquid drop through an ingress aperture
US4233029A (en) 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4189304A (en) 1978-10-27 1980-02-19 Miles Laboratories, Inc. Device and method for detecting myoglobin
US4237234A (en) 1978-10-30 1980-12-02 Meunier Henry E Device for use in the study of biochemical or enzymatic reactions produced by living organisms
IL55816A (en) 1978-10-30 1982-04-30 Ames Yissum Ltd Method for simultaneous immunoassay of several different antibodies and a kit therefor
US4246339A (en) 1978-11-01 1981-01-20 Millipore Corporation Test device
US4374925A (en) 1978-11-24 1983-02-22 Syva Company Macromolecular environment control in specific receptor assays
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
JPH0142041Y2 (en) 1978-12-11 1989-12-11
US4258001A (en) 1978-12-27 1981-03-24 Eastman Kodak Company Element, structure and method for the analysis or transport of liquids
US4235601A (en) 1979-01-12 1980-11-25 Thyroid Diagnostics, Inc. Test device and method for its use
US4361537A (en) 1979-01-12 1982-11-30 Thyroid Diagnostics, Inc. Test device and method for its use
US4288228A (en) 1979-01-31 1981-09-08 Technicon Instruments Corporation Whole blood analyses and diffusion apparatus therefor
US4274832A (en) 1979-02-12 1981-06-23 Eastman Kodak Company Analytical element and method for analysis of multiple analytes
GB2045431B (en) 1979-02-26 1983-04-20 Technicon Instr Immunoassay utilising two particulate reagents
US4268270A (en) 1979-04-30 1981-05-19 Children's Hospital Medical Center Glycosylated hemoglobin measurement
US4301139A (en) 1979-06-21 1981-11-17 Ames-Yissum Ltd. Multilayer column chromatography specific binding assay method, test device and test kit
US4271119A (en) 1979-07-23 1981-06-02 Eastman Kodak Company Capillary transport device having connected transport zones
US4281061A (en) 1979-07-27 1981-07-28 Syva Company Double antibody for enhanced sensitivity in immunoassay
US4305924A (en) 1979-08-08 1981-12-15 Ventrex Laboratories, Inc. Method and apparatus for performing in vitro clinical diagnostic tests using a solid phase assay system
US4305720A (en) 1979-08-20 1981-12-15 Becton Dickinson & Company Gentamicin assay and products therefor
US4305721A (en) 1979-08-20 1981-12-15 Becton Dickinson & Company Agglutination assay
US4270921A (en) 1979-09-24 1981-06-02 Graas Joseph E Microchromatographic device and method for rapid determination of a desired substance
JPS5647761A (en) 1979-09-27 1981-04-30 Fuji Photo Film Co Ltd Laminated analyzing piece and immunity analyzing method using the same
US4338094A (en) 1979-10-25 1982-07-06 Nasik Elahi Macroencapsulated immunosorbent assay technique
US4280816A (en) 1979-10-25 1981-07-28 Nasik Elahi Macroencapsulated immunosorbent assay technique and element therefor
US4391904A (en) 1979-12-26 1983-07-05 Syva Company Test strip kits in immunoassays and compositions therein
US4843000A (en) 1979-12-26 1989-06-27 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
US4540659A (en) 1981-04-17 1985-09-10 Syva Company Simultaneous calibration heterogeneous immunoassay
US4299916A (en) 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4533629A (en) 1981-04-17 1985-08-06 Syva Company Simultaneous calibration heterogeneous immunoassay
US4849338A (en) 1982-07-16 1989-07-18 Syntex (U.S.A.) Inc. Simultaneous calibration heterogeneous immunoassay
NL8000173A (en) 1980-01-11 1981-08-03 Akzo Nv USE OF WATER-DISPERSIBLE HYDROPHOBIC DYES AS LABELS IN IMMUNOCHEMICAL TESTS.
FI61965C (en) 1980-01-17 1982-10-11 Suovaniemi Finnpipette DETECTING OF HEMOGLOBIN AND DETECTION
US4323536A (en) 1980-02-06 1982-04-06 Eastman Kodak Company Multi-analyte test device
US4347312A (en) 1980-03-20 1982-08-31 Research Triangle Institute Detection of antibiotics in milk
US4452901A (en) 1980-03-20 1984-06-05 Ciba-Geigy Corporation Electrophoretically transferring electropherograms to nitrocellulose sheets for immuno-assays
EP0146654A3 (en) 1980-06-20 1986-08-20 Unilever Plc Processes and apparatus for carrying out specific binding assays
US5009996A (en) 1980-06-30 1991-04-23 International Immunoassay Laboratories, Inc. Two site cross-reaction immunometric sandwich assay method
US5009997A (en) 1980-06-30 1991-04-23 Shah Vipin D Two site cross-reaction immunometric sandwich assay method
US4333733A (en) 1980-07-17 1982-06-08 Eastman Kodak Company Continuous release of reagent in an analytical element to reduce assay interference
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4486530A (en) 1980-08-04 1984-12-04 Hybritech Incorporated Immunometric assays using monoclonal antibodies
US4816224A (en) 1980-08-05 1989-03-28 Boehringer Mannheim Gmbh Device for separating plasma or serum from whole blood and analyzing the same
DE3029579C2 (en) 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Method and means for separating plasma or serum from whole blood
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4357311A (en) 1980-10-03 1982-11-02 Warner-Lambert Company Substrate for immunoassay and means of preparing same
JPS5767860A (en) 1980-10-15 1982-04-24 Fuji Photo Film Co Ltd Material for multilayer analysis
US4668619A (en) 1980-10-30 1987-05-26 Miles Laboratories, Inc. Multilayer homogeneous specific binding assay device
EP0064063B1 (en) 1980-11-07 1985-09-11 Celltech Limited Assay for interferon
JPS5782766A (en) 1980-11-11 1982-05-24 Konishiroku Photo Ind Co Ltd Amynological measuring element
US4752562A (en) 1981-01-23 1988-06-21 Baxter Travenol Laboratories, Inc. Detection of serum antibody and surface antigen by radial partition immunoassay
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4774174A (en) 1981-01-23 1988-09-27 Baxter Travenol Laboratories, Inc. Solid phase system for ligand assay
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
US4425438A (en) 1981-03-13 1984-01-10 Bauman David S Assay method and device
US4442204A (en) 1981-04-10 1984-04-10 Miles Laboratories, Inc. Homogeneous specific binding assay device and preformed complex method
US4711955A (en) 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
US4362697A (en) 1981-04-20 1982-12-07 Miles Laboratories, Inc. Homogeneous specific binding assay test device having copolymer enhancing substance
US4447526A (en) 1981-04-20 1984-05-08 Miles Laboratories, Inc. Homogeneous specific binding assay with carrier matrix incorporating specific binding partner
US4365970A (en) 1981-05-01 1982-12-28 Smithkline Instruments, Inc. Specimen test slide and method for testing occult blood
US4604365A (en) 1981-06-02 1986-08-05 Electro-Nucleonics, Inc. Immunoprecipitation assay
DE3124699A1 (en) 1981-06-24 1983-01-13 Basf Ag, 6700 Ludwigshafen NEW 2-ARYL-3,4-DIAZA-BICYCLO (4.N.0.) ALKEN- (2) -ONE- (5), METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS
US4447529A (en) 1981-07-06 1984-05-08 Miles Laboratories, Inc. Preparing homogeneous specific binding assay element to avoid premature reaction
US4390343A (en) 1981-07-06 1983-06-28 Miles Laboratories, Inc. Multilayer analytical element having an impermeable radiation diffusing and blocking layer
DE3265794D1 (en) 1981-07-16 1985-10-03 Hoffmann La Roche Method for the detection of human occult blood in human stool samples
JPS5818167A (en) 1981-07-24 1983-02-02 Fuji Photo Film Co Ltd Analyzing film and analysis using said film
DE3130749C2 (en) 1981-08-04 1984-06-07 Boehringer Mannheim Gmbh, 6800 Mannheim Rapid diagnostic agent and method for its use, in particular for quantitative determinations
US4363874A (en) 1981-08-07 1982-12-14 Miles Laboratories, Inc. Multilayer analytical element having an impermeable radiation nondiffusing reflecting layer
US4608336A (en) 1981-08-27 1986-08-26 Miles Laboratories, Inc. #3B theophylline immunoassay employing 9-theophylline reagents
DE3134611A1 (en) 1981-09-01 1983-03-10 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR CARRYING OUT ANALYTICAL PROVISIONS AND MEANS SUITABLE FOR THIS
US4461829A (en) 1981-09-14 1984-07-24 Miles Laboratories, Inc. Homogeneous specific binding assay element and lyophilization production method
US4629690A (en) 1981-09-18 1986-12-16 Syntex (U.S.A.) Inc. Homogeneous enzyme specific binding assay on non-porous surface
US4446232A (en) 1981-10-13 1984-05-01 Liotta Lance A Enzyme immunoassay with two-zoned device having bound antigens
US4639419A (en) 1981-10-22 1987-01-27 Meloy Laboratories, Inc. Immunological color change test involving two differently colored reagent spots
US4464552A (en) 1981-10-29 1984-08-07 James River-Dixie/Northern, Inc. Packaging
US4562148A (en) 1981-11-06 1985-12-31 Miles Laboratories, Inc. Analytical element and method for preventing reagent migration
US5141875A (en) 1982-01-08 1992-08-25 Environmental Diagnostics, Inc. Rotary fluid manipulator
US4938927A (en) 1982-01-08 1990-07-03 Environmental Diagnostics, Inc. Rotary fluid manipulator
US4444193A (en) 1982-01-11 1984-04-24 Medtronic, Inc. Fluid absorbent quantitative test device
US5073484A (en) 1982-03-09 1991-12-17 Bio-Metric Systems, Inc. Quantitative analysis apparatus and method
US4506009A (en) 1982-03-30 1985-03-19 University Of California Heterogeneous immunoassay method
US4681782A (en) 1982-03-31 1987-07-21 Biostar Medical Products, Inc. Article for determining the presence of immune complexes
US4450231A (en) 1982-03-31 1984-05-22 Biostar Medical Products, Inc. Immunoassay for determination of immune complexes with polymer-coated plastic base
US4504585A (en) 1982-04-05 1985-03-12 Aalto Scientific, Ltd. Affinity immunoassay system
US4663278A (en) 1982-04-30 1987-05-05 Syva Company Agglutination dependent enzyme channeling immunoassay
US4435504A (en) 1982-07-15 1984-03-06 Syva Company Immunochromatographic assay with support having bound "MIP" and second enzyme
JPS5934154A (en) 1982-08-19 1984-02-24 Konishiroku Photo Ind Co Ltd Determination by means of immunoanalytical element
US4447546A (en) 1982-08-23 1984-05-08 Myron J. Block Fluorescent immunoassay employing optical fiber in capillary tube
DE3332144A1 (en) 1982-09-06 1984-03-08 Konishiroku Photo Industry Co., Ltd., Tokyo Analytical element
US4722906A (en) 1982-09-29 1988-02-02 Bio-Metric Systems, Inc. Binding reagents and methods
EP0112285B1 (en) 1982-11-19 1987-03-18 Ciba-Geigy Ag Reactive dyes, their preparation and their use
US4459358A (en) 1982-12-29 1984-07-10 Polaroid Corporation Multilayer element for analysis
AU529210B3 (en) 1983-02-02 1983-04-14 Australian Monoclonal Development Pty. Ltd. Monoclonal antibody in occult blood diagnosis
US4687735A (en) 1983-03-14 1987-08-18 Syntex (U.S.A.) Inc. Enzymatic poly-reactant channeling binding assay
US4666866A (en) 1983-04-19 1987-05-19 Krauth Gary H Immunoassay for antigens employing supported binder
AU2706384A (en) 1983-05-06 1984-11-08 Monoclonal Antibodies Inc. Colorimetric immunoassay on solid surface
US4851356A (en) 1983-05-06 1989-07-25 The Trustees Of Columbia University In The City Of New York Immunoassay for human chorionic gonadotropin
US4687732A (en) 1983-06-10 1987-08-18 Yale University Visualization polymers and their application to diagnostic medicine
US4757002A (en) 1983-06-13 1988-07-12 Regents Of The University Of Minnesota Method and kit for the estimation of serum immunoglobulin
US4550075A (en) 1983-06-22 1985-10-29 Kallestad Laboratories, Inc. Method for ligand determination utilizing an immunoassay monitorable by biotin-containing enzymes, and compositions therefor
US4552839A (en) 1983-08-01 1985-11-12 Syntex (U.S.A.) Inc. Determination of analytes in particle-containing medium
US4594327A (en) 1983-11-02 1986-06-10 Syntex (U.S.A.) Inc. Assay method for whole blood samples
GB8331514D0 (en) 1983-11-25 1984-01-04 Janssen Pharmaceutica Nv Visualization method
WO1985002466A1 (en) * 1983-12-02 1985-06-06 Vertrik Bioteknik Ab A device for chemical analyses and use thereof
DE3484505D1 (en) 1983-12-19 1991-05-29 Daiichi Pure Chemicals Co Ltd IMMUNTEST.
US4703017C1 (en) 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
GB8406752D0 (en) 1984-03-15 1984-04-18 Unilever Plc Chemical and clinical tests
US4632901A (en) 1984-05-11 1986-12-30 Hybritech Incorporated Method and apparatus for immunoassays
EP0170746A1 (en) 1984-08-07 1986-02-12 Covalent Technology Corporation Biologically active material test
US4656129A (en) 1984-08-16 1987-04-07 Becton Dickinson And Company Assay for a ligand by use of supported binder and sac lysing agent
US4826759A (en) * 1984-10-04 1989-05-02 Bio-Metric Systems, Inc. Field assay for ligands
US4999285A (en) 1984-11-15 1991-03-12 Syntex (U.S.A.) Inc. Chromatographic cassette
US4760142A (en) 1984-11-27 1988-07-26 Hoechst Celanese Corporation Divalent hapten derivatives
DE3445816C1 (en) 1984-12-15 1986-06-12 Behringwerke Ag, 3550 Marburg Flat diagnostic agent
US4782016A (en) 1985-01-18 1988-11-01 Eastman Kodak Company Analytical element and method for determination of theophylline by enzyme inhibition
US4740468A (en) 1985-02-14 1988-04-26 Syntex (U.S.A.) Inc. Concentrating immunochemical test device and method
JPS61212930A (en) 1985-03-19 1986-09-20 Oki Electric Ind Co Ltd Mobile set in broad band mobile communication system
US4678757A (en) 1985-04-11 1987-07-07 Smithkline Diagnostics, Inc. Device and method for whole blood separation and analysis
JPS61247965A (en) 1985-04-25 1986-11-05 Susumu Kogyo Kk Enzyme immunological measurement method
US4803170A (en) 1985-05-09 1989-02-07 Ultra Diagnostics Corporation Competitive immunoassay method, device and test kit
US4837395A (en) 1985-05-10 1989-06-06 Syntex (U.S.A.) Inc. Single step heterogeneous assay
US4693834A (en) 1986-05-05 1987-09-15 Murex Corporation Transverse flow diagnostic kit
US4623461A (en) 1985-05-31 1986-11-18 Murex Corporation Transverse flow diagnostic device
US4753893A (en) 1985-05-31 1988-06-28 Biostar Medical Products, Inc. Method and article for detection of immune complexes
JPH076984B2 (en) 1985-05-31 1995-01-30 株式会社日立製作所 Multiple item analysis method
US4931385A (en) 1985-06-24 1990-06-05 Hygeia Sciences, Incorporated Enzyme immunoassays and immunologic reagents
DE3523439A1 (en) 1985-06-29 1987-01-08 Boehringer Mannheim Gmbh TEST CARRIER
US4806311A (en) 1985-08-28 1989-02-21 Miles Inc. Multizone analytical element having labeled reagent concentration zone
US4806312A (en) 1985-08-28 1989-02-21 Miles Inc. Multizone analytical element having detectable signal concentrating zone
DE3530993A1 (en) 1985-08-30 1987-03-05 Miles Lab TEST STRIP WITH DETERMINABLE SAMPLE CAPACITY
US4900663A (en) 1985-09-13 1990-02-13 Environmental Diagnostics, Inc. Test kit for determining the presence of organic materials and method of utilizing same
US4761381A (en) 1985-09-18 1988-08-02 Miles Inc. Volume metering capillary gap device for applying a liquid sample onto a reactive surface
TW203120B (en) 1985-10-04 1993-04-01 Abbott Lab
US4868106A (en) 1985-10-17 1989-09-19 Konishiroku Photo Industry Co., Ltd. Analytical element and method for determining a component in a test sample
GB8526741D0 (en) 1985-10-30 1985-12-04 Boots Celltech Diagnostics Binding assay device
US5236826A (en) 1985-12-10 1993-08-17 Murex Corporation Immunoassay for the detection or quantitation of an analyte
US4868108A (en) 1985-12-12 1989-09-19 Hygeia Sciences, Incorporated Multiple-antibody detection of antigen
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4916056A (en) 1986-02-18 1990-04-10 Abbott Laboratories Solid-phase analytical device and method for using same
US4645743A (en) * 1986-03-11 1987-02-24 Smithkline Diagnostics, Inc. Method and device for collecting and testing for fecal occult blood
JPH0750114B2 (en) 1986-03-17 1995-05-31 富士写真フイルム株式会社 Analysis method using immunoassay instrument
US4960692A (en) 1986-03-18 1990-10-02 Fisher Scientific Company Assay employing binding pair members on particles and on a filter or membrane
GB8608157D0 (en) 1986-04-03 1986-05-08 Unilever Plc Ovulation test chart
DE3616105A1 (en) 1986-05-13 1987-11-19 Merck Patent Gmbh TEST STRIP
US4786594A (en) 1986-05-14 1988-11-22 Syntex (U.S.A.) Inc. Enzyme immunoassay
US4851210A (en) 1986-05-22 1989-07-25 Genelabs Incorporated Blood typing device
US4837145A (en) 1986-06-09 1989-06-06 Liotta Lance A Layered immunoassay using antibodies bound to transport particles to determine the presence of an antigen
AU602694B2 (en) 1986-06-09 1990-10-25 Ortho Diagnostic Systems Inc. Improved colloidal gold membrane assay
US4959305A (en) 1986-06-18 1990-09-25 Miles Inc. Reversible immobilization of assay reagents in a multizone test device
US4812293A (en) 1986-06-30 1989-03-14 Becton, Dickinson And Company Vacuum actuated assay device and method of using same
US4790979A (en) 1986-08-29 1988-12-13 Technimed Corporation Test strip and fixture
US5085988A (en) 1986-09-05 1992-02-04 Syntex (U.S.A.) Inc. Immunoseparating strip
US4963468A (en) 1986-09-05 1990-10-16 Syntex (U.S.A.) Inc. Immunoseparating strip
US5260193A (en) 1986-09-05 1993-11-09 Syntex (U.S.A.) Inc. Immunoseparating strip
US4959307A (en) 1986-09-05 1990-09-25 Syntex (U.S.A.) Inc. Immunoseparating strip
US5260194A (en) 1986-09-05 1993-11-09 Syntex (U.S.A.) Inc. Immunoseparating strip
DE3630999A1 (en) 1986-09-12 1988-03-17 Boehringer Mannheim Gmbh MULTI-LAYER TEST CARRIER
DE3782597T3 (en) 1986-09-18 2002-09-05 Pacific Biotech Inc Immunodiagnostic device.
US4960691A (en) 1986-09-29 1990-10-02 Abbott Laboratories Chromatographic test strip for determining ligands or receptors
GB8626081D0 (en) 1986-10-31 1986-12-03 Unilever Plc Printing processes
US4880751A (en) 1986-10-31 1989-11-14 Board Of Regents, The University Of Texas System Immunoglobulin adsorption
US5156952A (en) 1986-11-07 1992-10-20 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
US5030558A (en) 1986-11-07 1991-07-09 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
US5232835A (en) 1986-11-07 1993-08-03 Syntex (U.S.A.) Inc. Qualitative immunochromatographic method and device
EP0271204A3 (en) 1986-11-07 1989-10-25 Syntex (U.S.A.) Inc. Immunochromatographic method and device
DE3787078T2 (en) 1986-11-24 1993-12-09 Abbott Lab Test report effect for analytical solid phase device.
US4789629A (en) 1986-11-24 1988-12-06 Smithkline Beckman Corporation Method and device for collecting and testing for fecal occult blood
US4770853A (en) 1986-12-03 1988-09-13 New Horizons Diagnostics Corporation Device for self contained solid phase immunodiffusion assay
US4976926A (en) 1986-12-15 1990-12-11 Pall Corporation Vacuum diagnostic device
US4789526A (en) 1986-12-15 1988-12-06 Pall Corporation Vacuum diagnostic device
DE3643516A1 (en) 1986-12-19 1988-06-30 Boehringer Mannheim Gmbh TEST CARRIER FOR THE ANALYTICAL DETERMINATION OF INGREDIENTS OF BODY LIQUIDS
US4859603A (en) 1987-01-05 1989-08-22 Dole Associates, Inc. Personal diagnostic kit
GB8701432D0 (en) 1987-01-22 1987-02-25 Unilever Plc Assays
US5079142A (en) 1987-01-23 1992-01-07 Synbiotics Corporation Orthogonal flow immunoassays and devices
US4797260A (en) 1987-01-27 1989-01-10 V-Tech, Inc. Antibody testing system
AU592174B2 (en) 1987-02-17 1990-01-04 Genesis Labs, Inc. Immunoassay test strip
US4920046A (en) 1987-02-20 1990-04-24 Becton, Dickinson And Company Process, test device, and test kit for a rapid assay having a visible readout
US4847199A (en) 1987-02-27 1989-07-11 Eastman Kodak Company Agglutination immunoassay and kit for determination of a multivalent immune species using a buffered salt wash solution
US4918025A (en) 1987-03-03 1990-04-17 Pb Diagnostic Systems, Inc. Self contained immunoassay element
CA1303983C (en) 1987-03-27 1992-06-23 Robert W. Rosenstein Solid phase assay
JPH0684970B2 (en) 1987-03-31 1994-10-26 株式会社京都医科学研究所 Method of detecting occult blood in feces
US4803048A (en) 1987-04-02 1989-02-07 Nason Frederic L Laboratory kit
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
IT1206777B (en) 1987-04-06 1989-05-03 Chemetron Del Dr Del Campo Gio IMMUNOLOGICAL OR CHEMICAL ANALYSIS PROCEDURE FOR THE DETERMINATION OF PROTEINS IN BIOLOGICAL FLUIDS AND ITS COMPLETE (KIT) OF ANALYTICAL MEANS.
US4788136A (en) 1987-04-07 1988-11-29 Abbott Laboratories Diagnostic immunoassay by solid phase separation for digoxin
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
US5137808A (en) 1987-04-07 1992-08-11 Syntex (U.S.A.) Inc. Immunoassay device
US4956275A (en) 1987-04-14 1990-09-11 Molecular Devices Corporation Migratory detection immunoassay
DE3856421T2 (en) 1987-04-27 2000-12-14 Unilever Nv Specific binding test procedures
DE3715485A1 (en) 1987-05-09 1988-11-17 Boehringer Mannheim Gmbh STABILIZATION OF SS GALACTOSIDASE
US4855240A (en) 1987-05-13 1989-08-08 Becton Dickinson And Company Solid phase assay employing capillary flow
US4814142A (en) 1987-05-22 1989-03-21 Polymer Technology International Corp. Test strip having a non-particulate dialyzed polymer layer
US4904583A (en) 1987-05-26 1990-02-27 Becton, Dickinson And Company Cascade immunoassay by multiple binding reactions
CA1313616C (en) 1987-06-01 1993-02-16 Robert B. Sargeant Lateral flow, non-bibulous membrane protocols
US4943522A (en) 1987-06-01 1990-07-24 Quidel Lateral flow, non-bibulous membrane assay protocols
JPS63305251A (en) 1987-06-05 1988-12-13 Dai Ichi Pure Chem Co Ltd Immunoassay utilizing latex aggregation reaction
IL85899A0 (en) 1987-06-10 1988-09-30 Miles Inc Method,test device and test kit for separating labeled reagent in an immunometric binding assay
US4810470A (en) 1987-06-19 1989-03-07 Miles Inc. Volume independent diagnostic device
US4999287A (en) 1988-05-19 1991-03-12 Chemtrak Corporation Direct measuring assay strip and method of use thereof
US5215886A (en) 1987-06-22 1993-06-01 Patel P Jivan HDL determination in whole blood
US5120643A (en) 1987-07-13 1992-06-09 Abbott Laboratories Process for immunochromatography with colloidal particles
US4874692A (en) 1987-07-20 1989-10-17 Eastman Kodak Company Binder composition and analytical element having stabilized peroxidase in layer containing the composition
US4883764A (en) 1987-07-20 1989-11-28 Kloepfer Mary A Blood test strip
US4981786A (en) 1987-09-04 1991-01-01 Syntex (U.S.A.) Inc. Multiple port assay device
DE3879048T2 (en) 1987-09-11 1993-09-02 Abbott Lab DEVICE FOR LATERAL IMMUNOCHROMATOGRAPHIC DETERMINATION.
US4956302A (en) 1987-09-11 1990-09-11 Abbott Laboratories Lateral flow chromatographic binding assay device
US4923680A (en) 1987-09-18 1990-05-08 Eastman Kodak Company Test device containing an immunoassay filter with a flow-delaying polymer
US4912034A (en) 1987-09-21 1990-03-27 Biogenex Laboratories Immunoassay test device and method
US4853335A (en) 1987-09-28 1989-08-01 Olsen Duane A Colloidal gold particle concentration immunoassay
DE3733084A1 (en) 1987-09-30 1989-04-13 Boehringer Mannheim Gmbh TEST CARRIER FOR ANALYTICAL DETERMINATION OF A COMPONENT OF A BODY LIQUID
US5006464A (en) 1987-10-01 1991-04-09 E-Y Laboratories, Inc. Directed flow diagnostic device and method
US4902629A (en) 1987-10-06 1990-02-20 Personal Diagnostics, Inc. Apparatus and processes for facilitating reaction between analyte and test reagent system
US4859612A (en) 1987-10-07 1989-08-22 Hygeia Sciences, Inc. Metal sol capture immunoassay procedure, kit for use therewith and captured metal containing composite
GB8725458D0 (en) * 1987-10-30 1987-12-02 Unilever Plc Chemical testing
US5275785A (en) 1987-10-30 1994-01-04 Unilever Patent Holdings B.V. Test device for detecting an analyte in a liquid sample
US5256372A (en) 1987-11-06 1993-10-26 Idexx Corporation Dipstick test device including a removable filter assembly
DE3878167T2 (en) 1987-11-16 1993-05-27 Janssen Pharmaceutica Nv GENERAL APPLICABLE DETECTING SYSTEM BASED ON ULTRA-SMALL COLLOIDAL METAL PARTICLES.
US4818677A (en) 1987-12-03 1989-04-04 Monoclonal Antibodies, Inc. Membrane assay using focused sample application
US5006474A (en) 1987-12-16 1991-04-09 Disease Detection International Inc. Bi-directional lateral chromatographic test device
US4988627A (en) 1987-12-18 1991-01-29 Eastman Kodak Company Test device with dried reagent drops on inclined wall
AU619231B2 (en) 1987-12-21 1992-01-23 Abbott Laboratories Chromatographic binding assay devices and methods
US4977078A (en) 1987-12-22 1990-12-11 Olympus Optical Co., Ltd. Plate substrate immunoassay device and method for performing a multi-test immunoassay on a specimen
US5209904A (en) 1987-12-23 1993-05-11 Abbott Laboratories Agglutination reaction device utilizing selectively impregnated porous material
CA1339723C (en) 1988-01-19 1998-03-17 Philip Mcmahon Immunoassay with multiple test spots
US5206177A (en) 1988-01-21 1993-04-27 Boehringer Mannheim Corporation Apparatus for determining an analyte and method therefor
US5114673A (en) 1988-01-21 1992-05-19 Boehringer Mannheim Corporaton Apparatus for determination of a component in a sample
EP0327395A3 (en) 1988-02-05 1990-12-27 Idexx Corp. Assay kit and method
US4952517A (en) 1988-02-08 1990-08-28 Hygeia Sciences, Inc. Positive step immunoassay
US5104793A (en) 1988-02-16 1992-04-14 Boehringer Mannheim Corporation Method for determining an analyte in a liquid sample using a zoned test device and an inhibitor for a label used in said method
NL8800796A (en) 1988-03-29 1989-10-16 X Flow Bv METHOD FOR THE CHEMICAL ANALYSIS OF BODY FLUID COMPONENTS, AND A TESTING DEVICE AND TEST PACKAGE FOR SUCH ANALYSIS.
US5202267A (en) 1988-04-04 1993-04-13 Hygeia Sciences, Inc. Sol capture immunoassay kit and procedure
US5162237A (en) 1988-04-11 1992-11-10 Miles Inc. Reaction cassette for preforming sequential analytical assays by noncentrifugal and noncapillary manipulations
DE3814370A1 (en) 1988-04-28 1989-11-09 Boehringer Mannheim Gmbh TEST PROVIDER FOR THE ANALYSIS OF A SAMPLING FLUID, METHOD FOR CARRYING OUT SUCH ANALYSIS AND METHOD OF PRODUCTION
US5145784A (en) 1988-05-04 1992-09-08 Cambridge Biotech Corporation Double capture assay method employing a capillary flow device
US4963325A (en) 1988-05-06 1990-10-16 Hygeia Sciences, Inc. Swab expressor immunoassay device
US5137804A (en) 1988-05-10 1992-08-11 E. I. Du Pont De Nemours And Company Assay device and immunoassay
US5164294A (en) 1988-05-17 1992-11-17 Syntex (U.S.A.) Inc. Method for immunochromatographic analysis
US5039607A (en) 1988-05-17 1991-08-13 Syntex (U.S.A.) Inc. Method for immunochromatographic analysis
US5094962A (en) 1988-06-13 1992-03-10 Eastman Kodak Company Microporous article having a stabilized specific binding reagent, a method for its use and a diagnostic test kit
US5051237A (en) 1988-06-23 1991-09-24 P B Diagnostic Systems, Inc. Liquid transport system
CA1335880C (en) 1988-07-14 1995-06-13 Thomas P. O'connor Detection of an antibody and antigen in an immunoassay
US5096809A (en) 1988-07-25 1992-03-17 Pacific Biotech, Inc. Whole blood assays using porous membrane support devices
US4877586A (en) 1988-07-27 1989-10-31 Eastman Kodak Company Sliding test device for assays
DE3826057A1 (en) 1988-07-30 1990-02-01 Boehringer Mannheim Gmbh TEST TESTER FOR THE ANALYTICAL DETERMINATION OF AN INGREDIENT OF A LIQUID SAMPLE
US4959197A (en) 1988-09-07 1990-09-25 Bio-Rad Laboratories, Inc. Filter canister for immunoassays
US5030555A (en) 1988-09-12 1991-07-09 University Of Florida Membrane-strip reagent serodiagnostic apparatus and method
US5182191A (en) 1988-10-14 1993-01-26 Pacific Biotech, Inc. Occult blood sampling device and assay
US5079172A (en) 1988-11-04 1992-01-07 Board Of Trustees Operating Michigan State University Method for detecting the presence of antibodies using gold-labeled antibodies and test kit
WO1990005906A1 (en) * 1988-11-14 1990-05-31 Idexx Corporation Dual absorbent analyte detection
US5079174A (en) 1988-12-08 1992-01-07 Boehringer Mannheim Corporation Apparatus for sequential determination of an analyte in a fluid sample
US5106758A (en) 1988-12-12 1992-04-21 Technicon Instruments Corporation Analytical test device and the use thereof
DE3842702A1 (en) 1988-12-19 1990-06-21 Boehringer Mannheim Gmbh TEST CARRIER FOR ANALYTICAL EXAMINATION OF A SAMPLING LIQUID WITH THE AID OF A SPECIFIC BINDING REACTION OF TWO BIOAFFIN BINDING PARTNERS AND A CORRESPONDING TEST PROCEDURE
US5202268A (en) 1988-12-30 1993-04-13 Environmental Diagnostics, Inc. Multi-layered test card for the determination of substances in liquids
US5028535A (en) 1989-01-10 1991-07-02 Biosite Diagnostics, Inc. Threshold ligand-receptor assay
GB8903627D0 (en) 1989-02-17 1989-04-05 Unilever Plc Assays
US4960565A (en) 1989-03-14 1990-10-02 Ecostix Environmental Inc. Acid monitoring kit
US5264180A (en) 1989-03-16 1993-11-23 Chemtrak, Inc. Mobile reagents in an analyte assay in a self-contained apparatus
US5132086A (en) 1990-02-06 1992-07-21 Chemtrak Corporation Non-instrumented cholesterol assay
US4933092A (en) 1989-04-07 1990-06-12 Abbott Laboratories Methods and devices for the separation of plasma or serum from whole blood
US5064541A (en) 1989-04-07 1991-11-12 Abbott Laboratories Devices and methods for the collection of a predetermined volume of plasma or serum
US5135872A (en) 1989-04-28 1992-08-04 Sangstat Medical Corporation Matrix controlled method of delayed fluid delivery for assays
US5100619A (en) 1989-05-09 1992-03-31 Beckman Instruments, Inc. Device and method for collecting fecal occult blood specimens
US5120662A (en) 1989-05-09 1992-06-09 Abbott Laboratories Multilayer solid phase immunoassay support and method of use
US5100620A (en) 1989-05-15 1992-03-31 Miles, Inc. Capillary tube/gap reagent format
US5234813A (en) 1989-05-17 1993-08-10 Actimed Laboratories, Inc. Method and device for metering of fluid samples and detection of analytes therein
US5087556A (en) 1989-05-17 1992-02-11 Actimed Laboratories, Inc. Method for quantitative analysis of body fluid constituents
DE3922960A1 (en) 1989-07-12 1991-01-17 Boehringer Mannheim Gmbh METHOD FOR DETERMINING AN ANALYTE
US5135716A (en) 1989-07-12 1992-08-04 Kingston Diagnostics, L.P. Direct measurement of HDL cholesterol via dry chemistry strips
AU640162B2 (en) 1989-08-28 1993-08-19 Lifescan, Inc. Blood separation and analyte detection techniques
US5185127A (en) 1989-09-21 1993-02-09 Becton, Dickinson And Company Test device including flow control means
US5024323A (en) 1989-09-25 1991-06-18 Bernard Bolton Suture extender and needle guard
US5075078A (en) 1989-10-05 1991-12-24 Abbott Laboratories Self-performing immunochromatographic device
JPH03138646A (en) 1989-10-25 1991-06-13 Konica Corp Method for processing silver halide photographic sensitive material
US5135873A (en) 1989-11-27 1992-08-04 Syntex (U.S.A.) Inc. Device and method for completing a fluidic circuit which employs a liquid expandable piece of bibulous material
US5104812A (en) * 1989-11-27 1992-04-14 Syntex (U.S.A.) Inc. Device and method for interrupting capillary flow
US5260222A (en) 1989-11-27 1993-11-09 Syntex (U.S.A.) Inc. Device and method for completing a fluidic circuit which employs a liquid expandable piece of bibulous material
US5141850A (en) * 1990-02-07 1992-08-25 Hygeia Sciences, Inc. Porous strip form assay device method
US5096837A (en) 1990-02-08 1992-03-17 Pacific Biotech, Inc. Immunochromatographic assay and method of using same
DE4005021A1 (en) 1990-02-19 1991-08-22 Boehringer Mannheim Gmbh TEST CARRIER FOR ANALYSIS OF A SAMPLING LIQUID
TW199858B (en) 1990-03-30 1993-02-11 Fujirebio Kk
US5258163A (en) 1990-04-14 1993-11-02 Boehringer Mannheim Gmbh Test carrier for analysis of fluids
US5212060A (en) 1990-04-27 1993-05-18 Genesis Labs, Inc. Dry test strip comprising a dextran barrier for excluding erythrocytes
DE4015590A1 (en) 1990-05-15 1991-11-21 Boehringer Mannheim Gmbh TEST CARRIER FOR THE DETERMINATION OF IONS
US5238652A (en) 1990-06-20 1993-08-24 Drug Screening Systems, Inc. Analytical test devices for competition assay for drugs of non-protein antigens using immunochromatographic techniques
US5158869A (en) 1990-07-06 1992-10-27 Sangstat Medical Corporation Analyte determination using comparison of juxtaposed competitive and non-competitive elisa results and device therefore
US5119941A (en) 1990-11-23 1992-06-09 Lepie Eric J Matchbook-like personal dental and nail hygiene apparatus and method
US5294369A (en) 1990-12-05 1994-03-15 Akzo N.V. Ligand gold bonding
US5106582A (en) 1990-12-18 1992-04-21 Smithkline Diagnostics, Inc. Specimen test slide and method of testing for fecal occult blood
US5143210A (en) 1991-01-31 1992-09-01 Warwick S John Foldable protective package for storing, dispensing, and displaying diagnostic kit components
US5252492A (en) 1991-03-12 1993-10-12 University Of Utah Research Foundation Fluorescence assay for ligand or receptor utilizing size exclusion

Also Published As

Publication number Publication date
EP0586595A1 (en) 1994-03-16
DE69233290D1 (en) 2004-02-26
EP0874241A1 (en) 1998-10-28
ES2127754T3 (en) 1999-05-01
EP0874241B1 (en) 2004-01-21
JP3386122B2 (en) 2003-03-17
DE69233546D1 (en) 2005-09-29
EP1376130A2 (en) 2004-01-02
EP1376130B1 (en) 2005-08-24
JPH06508215A (en) 1994-09-14
WO1992021977A1 (en) 1992-12-10
DE69227834D1 (en) 1999-01-21
EP0586595B1 (en) 1998-12-09
CA2103052C (en) 2005-12-27
FI935244A (en) 1993-11-25
DE69233290T2 (en) 2004-11-18
FI935244A0 (en) 1993-11-25
ATE174432T1 (en) 1998-12-15
DE69227834T2 (en) 1999-04-29
DE69233546T2 (en) 2006-05-18
AU665956B2 (en) 1996-01-25
DK0586595T3 (en) 1999-08-16
AU2185292A (en) 1993-01-08
US6168956B1 (en) 2001-01-02
EP1376130A3 (en) 2004-01-14

Similar Documents

Publication Publication Date Title
CA2103052A1 (en) Assay device
HU9502835D0 (en) Opposable-element chromatographic assay device
CA2259307A1 (en) Chromatographic assay or test device
CA2286680A1 (en) Detachable-element assay device
EP0399184A3 (en) Reagents, methods and kits for an amphetamine-class fluorescence polarization immunoassay
DE60114146D1 (en) Immunochromatographic Assay Devices with Separation Elements
CA2254108A1 (en) Improvements in or relating to specific binding assays
EP1111386A3 (en) Test strip for the assay of an analyte in a liquid sample
EP0298368A3 (en) Non-metal colloidal particle immunoassay
AU2935989A (en) Test method and reagent kit therefor
EP0227173A3 (en) New method for the detection of specific binding agents and their corresponding bindable substances
DE69030004D1 (en) METHOD AND DEVICE FOR DETECTING AN ANALYT
AU547916B2 (en) Wipe-off test device
EP0402846A3 (en) Fluorescence polarization immunoassay for tetrahydrocannabinoids
CA2110049A1 (en) Devices for performing ion-capture binding assays
CA2158570A1 (en) Opposable-element chromatographic assay device
WO2001044779A3 (en) Method of processing and testing powdered samples using immunochromatographic strip tests
EP0379347A3 (en) Enzyme-labeled receptor composition, diagnostic kit and use in method to determine a ligand
CA2114440A1 (en) Differential binding affinities and dissociation assays based thereon

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry