CA2106073A1 - Composition for promoting tissue repair and regeneration - Google Patents

Composition for promoting tissue repair and regeneration

Info

Publication number
CA2106073A1
CA2106073A1 CA002106073A CA2106073A CA2106073A1 CA 2106073 A1 CA2106073 A1 CA 2106073A1 CA 002106073 A CA002106073 A CA 002106073A CA 2106073 A CA2106073 A CA 2106073A CA 2106073 A1 CA2106073 A1 CA 2106073A1
Authority
CA
Canada
Prior art keywords
regeneration
composition
tissue repair
promoting tissue
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002106073A
Other languages
French (fr)
Other versions
CA2106073C (en
Inventor
Robert B. Rutherford
Marc F. Charette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Curis Inc
Original Assignee
Curis, Inc.
Creative Biomolecules, Inc.
University Of Connecticut
Robert B. Rutherford
Marc F. Charette
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis, Inc., Creative Biomolecules, Inc., University Of Connecticut, Robert B. Rutherford, Marc F. Charette filed Critical Curis, Inc.
Publication of CA2106073A1 publication Critical patent/CA2106073A1/en
Application granted granted Critical
Publication of CA2106073C publication Critical patent/CA2106073C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Disclosed is a method for the regeneration of tissue, the treatment of external wounds and the treatment of periodontal dis-ease comprising applying to the affected tissue an effective amount of a composition comprised of platelet-derived growth factor (PDGF) and an anti-inflammatory compound. The presence of the anti-inflammatory compound potentiates the activity of PDGF in stimulating cell growth, thereby enhancing tissue regeneration and/or wound healing.
CA002106073A 1991-03-12 1992-03-12 Composition for promoting tissue repair and regeneration Expired - Fee Related CA2106073C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/669,070 US5149691A (en) 1991-03-12 1991-03-12 Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
US669,070 1991-03-12
PCT/US1992/002043 WO1992016181A2 (en) 1991-03-12 1992-03-12 Composition for promoting tissue repair and regeneration

Publications (2)

Publication Number Publication Date
CA2106073A1 true CA2106073A1 (en) 1993-09-13
CA2106073C CA2106073C (en) 2003-09-30

Family

ID=24684879

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002106073A Expired - Fee Related CA2106073C (en) 1991-03-12 1992-03-12 Composition for promoting tissue repair and regeneration

Country Status (8)

Country Link
US (2) US5149691A (en)
EP (1) EP0575484B1 (en)
JP (1) JPH07505858A (en)
AT (1) ATE196604T1 (en)
AU (1) AU656372B2 (en)
CA (1) CA2106073C (en)
DE (1) DE69231486T2 (en)
WO (1) WO1992016181A2 (en)

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US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
US5408040A (en) * 1991-08-30 1995-04-18 University Of South Florida Connective tissue growth factor(CTGF)
US5770209A (en) * 1991-08-30 1998-06-23 University Of South Florida Acceleration of wound healing using connective tissue growth factor
US5837258A (en) * 1991-08-30 1998-11-17 University Of South Florida Induction of tissue, bone or cartilage formation using connective tissue growth factor
US7384634B2 (en) * 1991-08-30 2008-06-10 University Of South Florida Connective tissue growth factor
US5444151A (en) * 1992-05-15 1995-08-22 Ludwig Institute For Cancer Research Platelet derived growth factor antagonists
US5326695A (en) * 1992-05-15 1994-07-05 Ludwig Institute For Cancer Research Platelet derived growth factor agonists
DE4228457A1 (en) * 1992-08-27 1994-04-28 Beiersdorf Ag Production of heterodimeric PDGF-AB using a bicistronic vector system in mammalian cells
US5455041A (en) * 1993-09-13 1995-10-03 Research Foundation Of State University Of New York At Buffalo Method for inducing periodontal tissue regeneration
US5942496A (en) * 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6551618B2 (en) 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
EP0743066A3 (en) * 1995-05-16 1998-09-30 Mitsui Pharmaceuticals, Inc. Wound-healing agent
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5776193A (en) * 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
WO1997045533A1 (en) * 1996-05-28 1997-12-04 The Regents Of The University Of Michigan Engineering oral tissues
DE19754140A1 (en) * 1997-12-05 1999-06-24 Era Beschichtung Gmbh & Co Kg Interior material based on plastic, process for its production and use
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
WO2001032197A2 (en) * 1999-11-02 2001-05-10 Eli Lilly And Company Methods of using lp8, a pdgf-related protein, to treat musculoskeletal disorders
US7847087B2 (en) 2001-03-05 2010-12-07 Siemens Healthcare Diagnostics Inc. Methods and primers for evaluating HIV-1 mutations
CN1627951A (en) * 2001-06-07 2005-06-15 美商·邱氏顾问股份有限公司 Compositions and method for prophylaxis and treatment of aphthous ulcers and herpes simplex lesions
US7819888B2 (en) * 2001-10-23 2010-10-26 Innovasive Devices, Inc. Method and apparatus for harvesting and implanting bone plugs
DE10152956A1 (en) * 2001-10-26 2003-05-15 Fresenius Kabi De Gmbh A pharmaceutical composition comprising a growth factor and / or a cytokine and an antiseptic biguanide
RU2308954C2 (en) 2002-05-09 2007-10-27 Медиджинез Pharmaceutical composition containing blood plasma or serum for treatment of wounds
US20040018220A1 (en) * 2002-07-26 2004-01-29 Chiou Consulting, Inc. Aqueous compositions for facial cosmetics
US6616923B1 (en) * 2002-07-26 2003-09-09 Chiou Consulting, Inc. Aqueous compositions for facial cosmetics
ATE510605T1 (en) 2003-03-14 2011-06-15 Univ Columbia SYSTEMS AND METHODS FOR BLOOD BASED THERAPY USING A MEMBRANELESS MICROFLUID EXCHANGE DEVICE
US20060076295A1 (en) 2004-03-15 2006-04-13 The Trustees Of Columbia University In The City Of New York Systems and methods of blood-based therapies having a microfluidic membraneless exchange device
US7309232B2 (en) * 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
US7258875B2 (en) * 2003-12-04 2007-08-21 Chiou Consulting, Inc. Compositions and methods for topical treatment of skin infection
US8293890B2 (en) * 2004-04-30 2012-10-23 Advanced Cardiovascular Systems, Inc. Hyaluronic acid based copolymers
GB0414803D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Composition
US7473678B2 (en) 2004-10-14 2009-01-06 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods of use thereof
US20060115266A1 (en) * 2004-12-01 2006-06-01 Gil Levi All-optical protection signaling systems and methods in optical communication networks
EP1917039A4 (en) * 2005-08-01 2011-01-19 Genera Istrazivanja D O O Methods and compositions for regenerating articular cartilage
NZ571113A (en) 2005-11-17 2012-02-24 Biomimetic Therapeutics Inc Maxillofacial bone augmentation using rhpdgf-bb and a biocompatible matrix
CN101370821B (en) 2006-01-23 2012-07-18 伊玛吉恩有限公司 Novel peptide and uses thereof
EP1991282B1 (en) * 2006-02-09 2013-06-19 BioMimetic Therapeutics, LLC Compositions and methods for treating bone
CN101534917A (en) 2006-05-22 2009-09-16 纽约市哥伦比亚大学理事会 Systems and methods of microfluidic membraneless exchange using filtration of extraction fluid outlet streams
JP5484047B2 (en) 2006-06-30 2014-05-07 バイオミメティック セラピューティクス， エルエルシー PDGF-biomatrix composition and method for treating rotator cuff injury
US9161967B2 (en) 2006-06-30 2015-10-20 Biomimetic Therapeutics, Llc Compositions and methods for treating the vertebral column
EP2462895B1 (en) * 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
AU2013203287B2 (en) * 2006-11-03 2015-12-17 Biomimetic Therapeutics, Llc. Compositions and methods for arthrodetic procedures
US9511076B2 (en) * 2008-05-30 2016-12-06 Clarion Research Group Formulations and methods for recovery from dental surgery
US8282963B2 (en) * 2007-10-15 2012-10-09 The Regents Of The University Of Colorado, A Body Corporate Methods for extracting platelets and compositions obtained therefrom
ES2543254T3 (en) 2008-01-07 2015-08-17 Rapid Pathogen Screening, Inc. Use of peptides to stimulate wound healing
MX2010008591A (en) 2008-02-04 2010-08-30 Univ Columbia Fluid separation devices, systems and methods.
CA2715254A1 (en) 2008-02-07 2009-08-13 Biomimetic Therapeutics, Inc. Compositions and methods for distraction osteogenesis
WO2010030714A2 (en) 2008-09-09 2010-03-18 Biomimetic Therapeutics, Inc. Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries
WO2010100282A1 (en) * 2009-03-06 2010-09-10 Universite Paris Descartes Method for treating cancer
NZ601559A (en) 2010-02-22 2014-10-31 Biomimetic Therapeutics Llc Platelet-derived growth factor compositions and methods for the treatment of tendinopathies
AU2011267081A1 (en) 2010-06-14 2013-01-17 Gene Signal International Sa Novel peptides for wound healing
EP2395015B1 (en) 2010-06-14 2013-03-06 Gene Signal International SA Peptides for wound healing
US8288334B2 (en) 2010-06-14 2012-10-16 Gene Signal International Sa Peptides for wound healing
US20130202576A1 (en) 2010-07-12 2013-08-08 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases
WO2013062995A1 (en) * 2011-10-25 2013-05-02 Biomimetic Therapeutics, Inc. Compositions and methods for treating deep partial and full thickness wounds and injuries
EP3311847A1 (en) 2012-02-16 2018-04-25 Atyr Pharma, Inc. Histidyl-trna synthetases for treating autoimmune and inflammatory diseases
EP3460054B1 (en) 2013-03-15 2020-10-21 aTyr Pharma, Inc. Histidyl-trna synthetase-fc conjugates
BR112017007645B1 (en) 2014-10-14 2023-05-02 Samuel Lynch COMPOSITIONS TO TREAT WOUNDS
WO2018195338A1 (en) 2017-04-20 2018-10-25 Atyr Pharma, Inc. Compositions and methods for treating lung inflammation
KR20200060997A (en) 2018-11-23 2020-06-02 (주)메디코스바이오텍 Pharmaceutical Composition for Treatment of Wounds
CZ308845B6 (en) 2019-01-21 2021-07-07 Globetech Innovation S.R.O Pharmaceutical composition of topically healing peptide components for use in the topical treatment of skin defects and / or for topical wound healing
PL433169A1 (en) 2020-03-06 2021-09-13 Gdański Uniwersytet Medyczny Lipopeptide conjugates and their salts, method for the preparation thereof, pharmaceutical composition containing a lipopeptide conjugate and its salts for the treatment of chronic wounds

Family Cites Families (10)

* Cited by examiner, † Cited by third party
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JPS6028999A (en) * 1983-06-30 1985-02-14 Maruho Kk Protein having cell proliferation accelerating action, its composition and its preparation
US4957742A (en) * 1984-11-29 1990-09-18 Regents Of The University Of Minnesota Method for promoting hair growth
US4861757A (en) * 1986-11-14 1989-08-29 Institute Of Molecular Biology Wound healing and bone regeneration using PDGF and IGF-I
US5124316A (en) * 1986-11-14 1992-06-23 President And Fellows Of Harvard College Method for periodontal regeneration
WO1988004180A1 (en) * 1986-12-11 1988-06-16 National Research Development Corporation Improvements in or relating to the use of epidermal growth factor
US4808402A (en) * 1987-05-29 1989-02-28 Northwestern University Method and compositions for modulating neovascularization
US4874746A (en) * 1987-12-22 1989-10-17 Institute Of Molecular Biology, Inc. Wound headling composition of TGF-alpha and PDGF
AU657472B2 (en) * 1990-03-06 1995-03-16 Claude Paul Genero Towel or blanket support device
US5149691A (en) * 1991-03-12 1992-09-22 Creative Biomolecules, Inc. Issue repair and regeneration through the use of platelet derived growth factor (pdgf) in combination with dexamethasone
ES2123004T3 (en) * 1991-04-12 1999-01-01 Creative Biomolecules Inc USE OF GROWTH FACTOR DERIVED FROM PLATELETS IN THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF GASTROINTESTINAL ULCERS.

Also Published As

Publication number Publication date
WO1992016181A3 (en) 1992-11-12
JPH07505858A (en) 1995-06-29
DE69231486T2 (en) 2001-04-26
WO1992016181A2 (en) 1992-10-01
EP0575484B1 (en) 2000-09-27
AU656372B2 (en) 1995-02-02
DE69231486D1 (en) 2000-11-02
US5149691A (en) 1992-09-22
ATE196604T1 (en) 2000-10-15
EP0575484A1 (en) 1993-12-29
AU1559192A (en) 1992-10-21
CA2106073C (en) 2003-09-30
US5376636A (en) 1994-12-27

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