CA2108266A1 - Convertible microemulsion formulations - Google Patents

Convertible microemulsion formulations

Info

Publication number
CA2108266A1
CA2108266A1 CA002108266A CA2108266A CA2108266A1 CA 2108266 A1 CA2108266 A1 CA 2108266A1 CA 002108266 A CA002108266 A CA 002108266A CA 2108266 A CA2108266 A CA 2108266A CA 2108266 A1 CA2108266 A1 CA 2108266A1
Authority
CA
Canada
Prior art keywords
microemulsion
water
emulsion
oil
microemulsion formulations
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002108266A
Other languages
French (fr)
Other versions
CA2108266C (en
Inventor
Albert J. Owen
Seang H. Yiv
Ani B. Sarkahian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LDS Technologies Inc
Original Assignee
Albert J. Owen
Seang H. Yiv
Ani B. Sarkahian
Affinity Biotech, Inc.
Ibah, Inc.
Lds Technologies, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albert J. Owen, Seang H. Yiv, Ani B. Sarkahian, Affinity Biotech, Inc., Ibah, Inc., Lds Technologies, Inc. filed Critical Albert J. Owen
Publication of CA2108266A1 publication Critical patent/CA2108266A1/en
Application granted granted Critical
Publication of CA2108266C publication Critical patent/CA2108266C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF] (Somatoliberin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Abstract

There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addi-tion of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long peri-ods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.
CA002108266A 1991-04-19 1992-04-15 Convertible microemulsion formulations Expired - Lifetime CA2108266C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US68769191A 1991-04-19 1991-04-19
US07/687,691 1991-04-19
US83734792A 1992-02-14 1992-02-14
US07/837,347 1992-02-14
US84193192A 1992-02-25 1992-02-25
US07/841,931 1992-02-25
PCT/US1992/003086 WO1992018147A1 (en) 1991-04-19 1992-04-15 Convertible microemulsion formulations

Publications (2)

Publication Number Publication Date
CA2108266A1 true CA2108266A1 (en) 1992-10-20
CA2108266C CA2108266C (en) 2003-06-03

Family

ID=27418494

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002108266A Expired - Lifetime CA2108266C (en) 1991-04-19 1992-04-15 Convertible microemulsion formulations

Country Status (16)

Country Link
US (3) US5444041A (en)
EP (1) EP0580778B1 (en)
JP (1) JPH06507172A (en)
CN (1) CN1066183A (en)
AT (1) ATE183099T1 (en)
AU (1) AU668509B2 (en)
CA (1) CA2108266C (en)
DE (1) DE69229779T2 (en)
DK (1) DK0580778T3 (en)
ES (1) ES2136620T3 (en)
GR (1) GR3031718T3 (en)
IE (1) IE921212A1 (en)
IL (1) IL101613A (en)
MX (1) MX9201816A (en)
PT (1) PT100400B (en)
WO (1) WO1992018147A1 (en)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
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ATE183099T1 (en) 1999-08-15
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PT100400A (en) 1993-08-31
US5444041A (en) 1995-08-22
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GR3031718T3 (en) 2000-02-29
US5633226A (en) 1997-05-27
DE69229779T2 (en) 1999-12-23
CA2108266C (en) 2003-06-03
CN1066183A (en) 1992-11-18
IE921212A1 (en) 1992-10-21
EP0580778B1 (en) 1999-08-11
AU668509B2 (en) 1996-05-09
WO1992018147A1 (en) 1992-10-29
AU1896692A (en) 1992-11-17
US5646109A (en) 1997-07-08
PT100400B (en) 1999-08-31
EP0580778A1 (en) 1994-02-02

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