CA2108575A1 - Method of manufacturing solid dispersion - Google Patents

Method of manufacturing solid dispersion

Info

Publication number
CA2108575A1
CA2108575A1 CA002108575A CA2108575A CA2108575A1 CA 2108575 A1 CA2108575 A1 CA 2108575A1 CA 002108575 A CA002108575 A CA 002108575A CA 2108575 A CA2108575 A CA 2108575A CA 2108575 A1 CA2108575 A1 CA 2108575A1
Authority
CA
Canada
Prior art keywords
solid dispersion
manufacturing solid
solid
twin
dissolving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002108575A
Other languages
French (fr)
Other versions
CA2108575C (en
Inventor
Kouichi Nakamichi
Shogo Izumi
Hiroyuki Yasuura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Shinyaku Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=14589572&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2108575(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2108575A1 publication Critical patent/CA2108575A1/en
Application granted granted Critical
Publication of CA2108575C publication Critical patent/CA2108575C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Abstract

The object of this invention is to provide a process for producing a solid dispersion, which has overcome the disadvantages of the conventional production technology for solid dispersions, The invention comprises employing a twin-screw extruder in the production of a solid dispersion.
In accordance with the invention, a solid dispersion can be expediently produced without heating a drug and a polymer to or beyond their melting points and without using an organic solvent for dissolving both components and the resulting solid dispersion has excellent performance characteristics.
CA002108575A 1991-04-16 1992-04-14 Method of manufacturing solid dispersion Expired - Lifetime CA2108575C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11255491 1991-04-16
JPHEI-3/112,554 1991-04-16
PCT/JP1992/000470 WO1992018106A1 (en) 1991-04-16 1992-04-14 Method of manufacturing solid dispersion

Publications (2)

Publication Number Publication Date
CA2108575A1 true CA2108575A1 (en) 1992-10-17
CA2108575C CA2108575C (en) 2002-10-22

Family

ID=14589572

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002108575A Expired - Lifetime CA2108575C (en) 1991-04-16 1992-04-14 Method of manufacturing solid dispersion

Country Status (12)

Country Link
US (1) US5456923A (en)
EP (1) EP0580860B2 (en)
JP (1) JP2527107B2 (en)
KR (1) KR0182801B1 (en)
AT (1) ATE159426T1 (en)
AU (1) AU1537292A (en)
CA (1) CA2108575C (en)
DE (1) DE69222847T3 (en)
DK (1) DK0580860T4 (en)
ES (1) ES2111065T5 (en)
GR (1) GR3025864T3 (en)
WO (1) WO1992018106A1 (en)

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