CA2108770A1 - Bmp-9 compositions - Google Patents

Bmp-9 compositions

Info

Publication number
CA2108770A1
CA2108770A1 CA002108770A CA2108770A CA2108770A1 CA 2108770 A1 CA2108770 A1 CA 2108770A1 CA 002108770 A CA002108770 A CA 002108770A CA 2108770 A CA2108770 A CA 2108770A CA 2108770 A1 CA2108770 A1 CA 2108770A1
Authority
CA
Canada
Prior art keywords
bmp
compositions
proteins
bone
processes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002108770A
Other languages
French (fr)
Other versions
CA2108770C (en
Inventor
John M. Wozney
Anthony J. Celeste
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
John M. Wozney
Anthony J. Celeste
Genetics Institute, Inc.
Genetics Institute, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John M. Wozney, Anthony J. Celeste, Genetics Institute, Inc., Genetics Institute, Llc filed Critical John M. Wozney
Publication of CA2108770A1 publication Critical patent/CA2108770A1/en
Application granted granted Critical
Publication of CA2108770C publication Critical patent/CA2108770C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Abstract

Purified BMP-9 proteins and processes for producing them are disclosed. The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.
CA002108770A 1991-06-25 1992-06-25 Bmp-9 compositions Expired - Fee Related CA2108770C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72059091A 1991-06-25 1991-06-25
US07/720,590 1991-06-25
PCT/US1992/005374 WO1993000432A1 (en) 1991-06-25 1992-06-25 Bmp-9 compositions

Publications (2)

Publication Number Publication Date
CA2108770A1 true CA2108770A1 (en) 1992-12-26
CA2108770C CA2108770C (en) 2007-04-03

Family

ID=24894572

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002108770A Expired - Fee Related CA2108770C (en) 1991-06-25 1992-06-25 Bmp-9 compositions

Country Status (11)

Country Link
US (1) US5661007A (en)
EP (1) EP0592562B1 (en)
JP (2) JP3485917B2 (en)
KR (1) KR100255415B1 (en)
AT (1) ATE175441T1 (en)
AU (1) AU652472B2 (en)
CA (1) CA2108770C (en)
DE (1) DE69228118T2 (en)
DK (1) DK0592562T3 (en)
ES (1) ES2127757T3 (en)
WO (1) WO1993000432A1 (en)

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ATE175441T1 (en) 1999-01-15
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ES2127757T3 (en) 1999-05-01
CA2108770C (en) 2007-04-03
KR100255415B1 (en) 2000-05-01
EP0592562A1 (en) 1994-04-20
JPH06508990A (en) 1994-10-13
AU2269992A (en) 1993-01-25
WO1993000432A1 (en) 1993-01-07
AU652472B2 (en) 1994-08-25
DE69228118T2 (en) 1999-08-19
JP3485917B2 (en) 2004-01-13
DE69228118D1 (en) 1999-02-18
US5661007A (en) 1997-08-26
EP0592562B1 (en) 1999-01-07
DK0592562T3 (en) 1999-08-30

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