CA2110290A1 - Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same - Google Patents

Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same

Info

Publication number
CA2110290A1
CA2110290A1 CA002110290A CA2110290A CA2110290A1 CA 2110290 A1 CA2110290 A1 CA 2110290A1 CA 002110290 A CA002110290 A CA 002110290A CA 2110290 A CA2110290 A CA 2110290A CA 2110290 A1 CA2110290 A1 CA 2110290A1
Authority
CA
Canada
Prior art keywords
same
injectable solutions
solutions containing
vascular occlusions
microspheres useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002110290A
Other languages
French (fr)
Other versions
CA2110290C (en
Inventor
Egisto Boschetti
Michel Brouard
Ludovic Drouet
Pierre Girot
Alexandre Laurent
Michel Wassef
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosphere Medical SA
Assistance Publique Hopitaux de Paris APHP
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2110290A1 publication Critical patent/CA2110290A1/en
Application granted granted Critical
Publication of CA2110290C publication Critical patent/CA2110290C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/06—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices

Abstract

The present invention concerns the use of microspheres for therapeutic embolization consisting of a hydrophilic acrylic copolymer coated with a cell adhesion promoter.
CA002110290A 1991-05-29 1992-05-20 Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same Expired - Lifetime CA2110290C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9106441A FR2676927B1 (en) 1991-05-29 1991-05-29 MICROSPHERES FOR USE IN THERAPEUTIC VASCULAR OCCLUSIONS AND INJECTABLE SOLUTIONS CONTAINING THEM.
FR91/06441 1991-05-29
PCT/US1992/004265 WO1992021327A1 (en) 1991-05-29 1992-05-20 Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same

Publications (2)

Publication Number Publication Date
CA2110290A1 true CA2110290A1 (en) 1992-12-10
CA2110290C CA2110290C (en) 2002-02-05

Family

ID=9413226

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002110290A Expired - Lifetime CA2110290C (en) 1991-05-29 1992-05-20 Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same

Country Status (11)

Country Link
US (2) US5635215A (en)
EP (1) EP0588875B1 (en)
JP (1) JP3509858B2 (en)
AT (1) ATE151284T1 (en)
AU (1) AU661319B2 (en)
CA (1) CA2110290C (en)
DE (1) DE69218938T2 (en)
DK (1) DK0588875T3 (en)
ES (1) ES2099827T3 (en)
FR (1) FR2676927B1 (en)
WO (1) WO1992021327A1 (en)

Families Citing this family (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4341478C2 (en) * 1993-12-02 1998-10-08 Max Delbrueck Centrum Antitumor therapy agents
US6251418B1 (en) * 1997-12-18 2001-06-26 C.R. Bard, Inc. Systems and methods for local delivery of an agent
US6197324B1 (en) 1997-12-18 2001-03-06 C. R. Bard, Inc. System and methods for local delivery of an agent
EP1522317A1 (en) * 1998-03-06 2005-04-13 Biosphere Medical, Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
JP5095049B2 (en) * 1998-03-06 2012-12-12 バイオスフィアー メディカル，インク． Implantable particles for the treatment of tissue bulking and gastroesophageal reflux disease, urinary incontinence, skin wrinkles
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
FR2784580B1 (en) * 1998-10-16 2004-06-25 Biosepra Inc POLYVINYL-ALCOHOL MICROSPHERES AND METHODS OF MAKING THE SAME
EP2305324B1 (en) * 1999-03-25 2014-09-17 Metabolix, Inc. Medical devices and applications of polyhydroxyalkanoate polymers
US20050049178A1 (en) * 1999-07-06 2005-03-03 Oberschwabenklinik Gmbh Agent for the occlusion of blood vessels
DE29911689U1 (en) * 1999-07-06 2000-04-06 Sterk Peter Agents for occluding organic tissue
US6855160B1 (en) 1999-08-04 2005-02-15 C. R. Bard, Inc. Implant and agent delivery device
US6676971B2 (en) 2000-03-13 2004-01-13 Biocure, Inc. Embolic compositions
AU4361601A (en) 2000-03-13 2001-09-24 Biocure Inc Hydrogel biomedical articles
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
EP1656957B1 (en) 2000-03-20 2015-06-03 Biosphere Medical, Inc. Injectable microspheres for tissue construction
EP1274472A2 (en) * 2000-03-20 2003-01-15 Biosphere Medical, Inc. Injectable and swellable microspheres for tissue bulking
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
ATE327783T1 (en) 2000-03-20 2006-06-15 Biosphere Medical Inc INJECTABLE MICROBEADS FOR TISSUE BUILDING
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
WO2001072280A2 (en) * 2000-03-24 2001-10-04 Biosphere Medical Inc. Microspheres for gene therapy
JP2003528130A (en) * 2000-03-24 2003-09-24 バイオスフィアー メディカル，インク． Microspheres for active embolization
US7232421B1 (en) 2000-05-12 2007-06-19 C. R. Bard, Inc. Agent delivery systems
US6355275B1 (en) 2000-06-23 2002-03-12 Carbon Medical Technologies, Inc. Embolization using carbon coated microparticles
US6394965B1 (en) 2000-08-15 2002-05-28 Carbon Medical Technologies, Inc. Tissue marking using biocompatible microparticles
FR2816847B1 (en) * 2000-11-22 2006-07-14 Assist Publ Hopitaux De Paris POROUS POLYMERIC BIOMATERIALS, PROCESS FOR PREPARATION AND USES
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
WO2002100444A1 (en) * 2001-06-08 2002-12-19 Biosphere Medical Inc. Colloidal metal labelled microparticles, their production and use
NZ532243A (en) 2001-09-12 2006-03-31 Virexx Medical Corp Vascular occlusion solid-phase agent with immobilised platelet binding agent
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7094369B2 (en) * 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7276254B2 (en) * 2002-05-07 2007-10-02 Xerox Corporation Emulsion/aggregation polymeric microspheres for biomedical applications and methods of making same
US7838699B2 (en) * 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US7670623B2 (en) 2002-05-31 2010-03-02 Materials Modification, Inc. Hemostatic composition
WO2003105917A2 (en) 2002-06-12 2003-12-24 Scimed Life Systems, Inc. Bulking agents
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7112620B2 (en) * 2002-10-18 2006-09-26 Albright Robert L Hemocompatible polymer systems & related methods
US20040168245A1 (en) * 2002-10-18 2004-09-02 Goodwin Edward L. Washable, protective hip pad construction
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
JP4686970B2 (en) * 2002-10-29 2011-05-25 東レ株式会社 Vascular embolic material
US20060069168A1 (en) * 2002-10-29 2006-03-30 Norikazu Tabata Vascular embolization material
EP1578455A4 (en) * 2002-11-04 2008-12-31 Biosphere Medical Inc Radioisotope-associated polymeric hydrogel microspheres and methods for producing and using the same
US7560160B2 (en) * 2002-11-25 2009-07-14 Materials Modification, Inc. Multifunctional particulate material, fluid, and composition
US7007972B1 (en) 2003-03-10 2006-03-07 Materials Modification, Inc. Method and airbag inflation apparatus employing magnetic fluid
JP2004313759A (en) * 2003-03-31 2004-11-11 Toray Ind Inc Blood vessel embolus material
WO2004101002A2 (en) 2003-05-08 2004-11-25 Tepha, Inc. Polyhydroxyalkanoate medical textiles and fibers
US6982501B1 (en) 2003-05-19 2006-01-03 Materials Modification, Inc. Magnetic fluid power generator device and method for generating power
EP1651273B1 (en) * 2003-07-08 2012-08-29 Tepha, Inc. Poly-4-hydroxybutyrate matrices for sustained drug delivery
US7200956B1 (en) 2003-07-23 2007-04-10 Materials Modification, Inc. Magnetic fluid cushioning device for a footwear or shoe
JP2007503221A (en) * 2003-08-22 2007-02-22 テファ， インコーポレイテッド Polyhydroxyalkanoate nerve regeneration device
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7448389B1 (en) 2003-10-10 2008-11-11 Materials Modification, Inc. Method and kit for inducing hypoxia in tumors through the use of a magnetic fluid
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
BRPI0510717B8 (en) * 2004-05-06 2021-05-25 Bioresponse Llc use of 3,3'-diindolylmethane (dim) or 2-(indol-3-ylmethyl)-3,3'-diindolylmethane (ltr)
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
EP1778305B1 (en) * 2004-08-03 2010-07-07 Tepha, Inc. Non-curling polyhydroxyalkanoate sutures
CA2579612A1 (en) * 2004-09-24 2006-04-06 Biosphere Medical, Inc. Microspheres capable of binding radioisotopes, optionally comprising metallic microparticles, and methods of use thereof
US20060073208A1 (en) 2004-10-01 2006-04-06 Allergan, Inc. Cosmetic neurotoxin compositions and methods
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
KR101153785B1 (en) 2004-10-25 2012-07-09 셀로노바 바이오사이언시스 저머니 게엠베하 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
WO2006083458A2 (en) * 2004-12-30 2006-08-10 Bioresponse Llc Use of diindolylmethane-related indoles for the treatment and prevention of respiratory syncytial virus associates conditions
WO2006078841A1 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles
CA2596283C (en) * 2005-01-28 2011-11-01 Tepha, Inc. Embolization using poly-4-hydroxybutyrate particles
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
CA2607228C (en) * 2005-05-09 2014-09-16 Biosphere Medical S.A. Compositions and methods using microspheres and non-ionic contrast agents
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
ATE520427T1 (en) * 2006-01-30 2011-09-15 Biosphere Medical Inc POROUS INTRAVASCULAR EMBOLIZATION PARTICLES AND METHOD FOR THE PRODUCTION THEREOF
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
CN101489563A (en) * 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 Pharmaceutical preparations for contraception and for preventing the risk of congenital malformations
WO2008057253A2 (en) 2006-10-27 2008-05-15 Bioresponse, L.L.C. Anti-parasitic methods and compositions utilizing diindolylmethane-related indoles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
US7943683B2 (en) * 2006-12-01 2011-05-17 Tepha, Inc. Medical devices containing oriented films of poly-4-hydroxybutyrate and copolymers
WO2008134580A2 (en) * 2007-04-27 2008-11-06 Amylin Pharmaceuticals, Inc. Drug delivery device
WO2009079555A2 (en) * 2007-12-17 2009-06-25 Anna Love Soft tissue filler
JP2012507562A (en) * 2008-10-30 2012-03-29 ダビド リウ Microspherical porous biocompatible scaffold and manufacturing method and apparatus thereof
WO2010062734A1 (en) * 2008-11-03 2010-06-03 University Of Maryland, Baltimore Blood coagulation inducing polymer hydrogel
CN102905733B (en) * 2009-10-06 2014-10-15 明尼苏达大学董事会 Bioresorbable embolization microspheres
EP2351779B1 (en) * 2010-01-27 2019-04-24 Biosphere Medical, Inc. Microspheres and method of making the microspheres
CA2831414C (en) * 2011-03-30 2016-03-22 Toray Industries, Inc. Biodegradable particle, vascular embolization material and method for producing biodegradable particles
JP6208749B2 (en) * 2012-05-24 2017-10-04 バイオスフィア メディカル，インコーポレイテッド Biomaterials suitable for use as drug-eluting and vascular occlusion implants detectable by magnetic resonance imaging
US8936795B2 (en) 2012-12-19 2015-01-20 Regents Of The University Of Minnesota Liquid embolic material including carboxymethyl chitosan crosslinked with carboxymethyl cellulose
CN105263477B (en) 2013-03-13 2019-01-15 生物领域医疗公司 Composition and correlation technique for radioactive isotope combination particle
WO2015042170A1 (en) 2013-09-17 2015-03-26 Wayne State University Compositions and uses of combinations of dim-related indoles and selected anti-androgen compounds
KR102352098B1 (en) 2013-09-19 2022-01-14 테루모 가부시키가이샤 Polymer particles
CA2923741C (en) 2013-09-19 2022-06-07 Microvention, Inc. Polymer films
AU2014346486B2 (en) 2013-11-08 2016-12-08 Terumo Corporation Polymer particles
US10500303B2 (en) 2014-08-15 2019-12-10 Tepha, Inc. Self-retaining sutures of poly-4-hydroxybutyrate and copolymers thereof
CA2969429C (en) 2014-12-11 2020-10-27 Tepha, Inc. Methods of orienting multifilament yarn and monofilaments of poly-4-hydroxybutyrate and copolymers thereof
US10626521B2 (en) 2014-12-11 2020-04-21 Tepha, Inc. Methods of manufacturing mesh sutures from poly-4-hydroxybutyrate and copolymers thereof
ES2834737T3 (en) * 2015-01-12 2021-06-18 Biosphere Medical Inc Radiopaque Monomers, Polymers and Microspheres and Related Methods
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
US10071181B1 (en) 2015-04-17 2018-09-11 Teleflex Innovations S.À.R.L. Resorbable embolization spheres
KR20180125957A (en) 2016-03-14 2018-11-26 바이오컴패티블스 유케이 엘티디 Emulsion containing particles
US10182979B2 (en) 2016-03-22 2019-01-22 Regents Of The University Of Minnesota Biodegradable microspheres
JP6728499B2 (en) 2016-09-28 2020-07-22 テルモ株式会社 Polymer particles
KR20220081358A (en) * 2019-10-07 2022-06-15 게르브 Non-degradable embolic microspheres
EP4041319A1 (en) * 2019-10-07 2022-08-17 Guerbet Non degradable radio-opaque embolisation microsphere

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797485A (en) * 1971-03-26 1974-03-19 Alza Corp Novel drug delivery device for administering drug into blood circulation in blood vessel
US4622362A (en) * 1981-03-30 1986-11-11 California Institute Of Technology Polyacrolein microspheres
US4413070A (en) * 1981-03-30 1983-11-01 California Institute Of Technology Polyacrolein microspheres
DE3360633D1 (en) * 1982-02-12 1985-10-03 Unitika Ltd Anti-cancer device
JPS61293911A (en) * 1985-06-24 1986-12-24 Teisan Seiyaku Kk Sustained release preparation
JPS62169723A (en) * 1986-01-22 1987-07-25 Teisan Seiyaku Kk Sustained release preparation

Also Published As

Publication number Publication date
FR2676927B1 (en) 1995-06-23
DE69218938D1 (en) 1997-05-15
ATE151284T1 (en) 1997-04-15
AU2016892A (en) 1993-01-08
US5635215A (en) 1997-06-03
DK0588875T3 (en) 1997-04-28
DE69218938T2 (en) 1997-07-31
WO1992021327A1 (en) 1992-12-10
CA2110290C (en) 2002-02-05
EP0588875A1 (en) 1994-03-30
US5648100A (en) 1997-07-15
AU661319B2 (en) 1995-07-20
EP0588875A4 (en) 1994-08-03
FR2676927A1 (en) 1992-12-04
JPH06508139A (en) 1994-09-14
JP3509858B2 (en) 2004-03-22
EP0588875B1 (en) 1997-04-09
ES2099827T3 (en) 1997-06-01

Similar Documents

Publication Publication Date Title
CA2110290A1 (en) Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
CA2090980A1 (en) Ligating clip applier
AU673995B2 (en) Vascular stent
AU673703B2 (en) Injector and use of the same
CA2169638A1 (en) Intravascular medical device
AU6266994A (en) Infra-red vascular angiography system
AU2253492A (en) Vascular occlusion removal devices and methods
AU4444693A (en) Nylon-peba copolymer catheter
AU1517595A (en) Universal mode vascular catheter system
EP0608853A3 (en) Vascular dilatation instrument and catheter.
AU620930B2 (en) Chemically modified hydrophilic prepolymers and polymers
AU4469689A (en) Spray gun with disposable liquid handling portion
GB2252306B (en) Titanium dioxide particles coated with an ester
AU5233493A (en) Improving the biocompatibility of solid surfaces
PH30794A (en) Inhibition of phosphatidylinositol 3-kinase with worthmannin and analogs thereof.
AU7719694A (en) Intravenous and transducer line organizer
EP0648492A3 (en) Inhibition of phosphatidylinositol 3-kinase with viridin, demethoxyviridin, viridiol, demethoxyviridiol, virone, wortmannolone, and analogs thereof.
ZA948934B (en) Catalyst composition for use in the polymerization and copolymerization of ethylene
CA2049895A1 (en) Fast cure in-mold coating
CA2202363A1 (en) Stent surface anchor
AU4098393A (en) Laminate and use of the same
AU7878994A (en) Binary vapor adhesion promoters and methods of using the same
CA2230159A1 (en) Use of aminoadamantane compounds as immunoregulators
AU6280394A (en) Ultrasonic activator
GB2229625B (en) Stepped storage and display shelf assembly

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry
MKEX Expiry

Effective date: 20120520