CA2113119A1 - Computer controlled cryoprotectant perfusion apparatus and method - Google Patents

Computer controlled cryoprotectant perfusion apparatus and method

Info

Publication number
CA2113119A1
CA2113119A1 CA002113119A CA2113119A CA2113119A1 CA 2113119 A1 CA2113119 A1 CA 2113119A1 CA 002113119 A CA002113119 A CA 002113119A CA 2113119 A CA2113119 A CA 2113119A CA 2113119 A1 CA2113119 A1 CA 2113119A1
Authority
CA
Canada
Prior art keywords
fluid flow
flow path
fluid
reservoirs
organ
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002113119A
Other languages
French (fr)
Other versions
CA2113119C (en
Inventor
Gregory M. Fahy
Bijan S. Khirabadi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
American National Red Cross
Original Assignee
Gregory M. Fahy
Bijan S. Khirabadi
The American National Red Cross
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gregory M. Fahy, Bijan S. Khirabadi, The American National Red Cross filed Critical Gregory M. Fahy
Publication of CA2113119A1 publication Critical patent/CA2113119A1/en
Application granted granted Critical
Publication of CA2113119C publication Critical patent/CA2113119C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0236—Mechanical aspects
    • A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
    • A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents

Abstract

A computer-controlled apparatus and method for perfusing a biological organ, such as a heart, kidney, liver, etc. The ap-paratus comprises a plurality of fluid reservoirs and an organ container for holding the biological organ. A first fluid flow path is defined as a loop from the plurality of reservoirs to necessary sensors and temperature conditioning means and back to the plu-rality of reservoirs. The reservoirs are selectively connectable to the first fluid flow path. Pump means are interposed in the first fluid flow path for pumping fluid from the first fluid flow path to a second fluid flow path. The organ container is located in this second fluid flow path. Pump means may also be included in the second fluid flow path for pumping fluid from the organ con-tainer to one or more of the reservoirs or to waste. One or more sensors are interposed in the fluid flow paths for sensing at least one of the concentration, temperature, pH, and pressure of the fluid flowing in the first and second fluid flow paths. Measuring means are interposed in the first and second fluid flow paths for measuring concentration and temperature differences between the upstream and downstream sides, in the fluid flow direction, of the organ container. The sensor(s) and the measuring means are connected to a programmable computer for providing a continuous information stream from the sensor(s) to the computer.
The computer is coupled to the selection means and the pump means to continuously selectively control (a) the flow of fluid from each of the reservoirs individually to the fluid flow paths, and (b) at least one of the concentration, temperature, pressure and pH
of the fluid flowing in the second fluid flow path, in accordance with a predetermined computer program without operator inter-vention.
CA002113119A 1991-07-08 1992-07-07 Computer controlled cryoprotectant perfusion apparatus and method Expired - Fee Related CA2113119C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/725,054 US5217860A (en) 1991-07-08 1991-07-08 Method for preserving organs for transplantation by vitrification
US725,054 1991-07-08
PCT/US1992/005711 WO1993000808A1 (en) 1991-07-08 1992-07-07 Computer controlled cryoprotectant perfusion apparatus and method

Publications (2)

Publication Number Publication Date
CA2113119A1 true CA2113119A1 (en) 1993-01-21
CA2113119C CA2113119C (en) 2003-05-06

Family

ID=24912973

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002113119A Expired - Fee Related CA2113119C (en) 1991-07-08 1992-07-07 Computer controlled cryoprotectant perfusion apparatus and method

Country Status (7)

Country Link
US (2) US5217860A (en)
EP (2) EP0594733A4 (en)
JP (1) JPH07500815A (en)
AT (1) ATE193181T1 (en)
CA (1) CA2113119C (en)
DE (1) DE69231106T2 (en)
WO (1) WO1993000808A1 (en)

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US5472876A (en) 1995-12-05
DE69231106D1 (en) 2000-06-29
ATE193181T1 (en) 2000-06-15
JPH07500815A (en) 1995-01-26
WO1993000808A1 (en) 1993-01-21
DE69231106T2 (en) 2001-02-01
EP0594733A4 (en) 1994-11-30
US5217860A (en) 1993-06-08
EP0800765B1 (en) 2000-05-24
EP0800765A3 (en) 1998-04-08
CA2113119C (en) 2003-05-06
EP0594733A1 (en) 1994-05-04
EP0800765A2 (en) 1997-10-15

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