CA2113268A1 - Measuring Molecular Change in the Ocular Lens - Google Patents

Measuring Molecular Change in the Ocular Lens

Info

Publication number
CA2113268A1
CA2113268A1 CA2113268A CA2113268A CA2113268A1 CA 2113268 A1 CA2113268 A1 CA 2113268A1 CA 2113268 A CA2113268 A CA 2113268A CA 2113268 A CA2113268 A CA 2113268A CA 2113268 A1 CA2113268 A1 CA 2113268A1
Authority
CA
Canada
Prior art keywords
ocular lens
measuring molecular
backscattered radiation
molecular change
fluorescent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2113268A
Other languages
French (fr)
Other versions
CA2113268C (en
Inventor
Mark A. Samuels
Scott W. Patterson
Jonathan A. Eppstein
Nai Teug Yu
Sven-Erik Bursell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Georgia Tech Research Corp
Original Assignee
Mark A. Samuels
Scott W. Patterson
Jonathan A. Eppstein
Nai Teug Yu
Sven-Erik Bursell
Georgia Tech Research Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mark A. Samuels, Scott W. Patterson, Jonathan A. Eppstein, Nai Teug Yu, Sven-Erik Bursell, Georgia Tech Research Corporation filed Critical Mark A. Samuels
Publication of CA2113268A1 publication Critical patent/CA2113268A1/en
Application granted granted Critical
Publication of CA2113268C publication Critical patent/CA2113268C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
    • A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
    • A61B3/117—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes
    • A61B3/1173—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for examining the anterior chamber or the anterior chamber angle, e.g. gonioscopes for examining the eye lens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Abstract

Apparatus and methods for noninvasively diagnosing diabetes mellitus, the prediabetic condition, cataracts, and other diseases in the human (or other) body are disclosed.
Diagnoses are made by illuminating ocular lens (L) or other tissue with a narrowband light source (15) at a selected wavelength, separating the backscattered radiation into fluorescent and Rayleigh components (55, 135), detecting (85) the backscattered radiation intensity at the peak of the fluorescent response, and normalizing the detected value with the detected intensity of its Rayleigh component. Measurements provided in this manner can be used as improved indicators of the presence or absence of certain diseases or conditions.
CA002113268A 1991-07-17 1992-07-16 Measuring molecular change in the ocular lens Expired - Lifetime CA2113268C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US731,533 1991-07-17
US07/731,533 US5203328A (en) 1991-07-17 1991-07-17 Apparatus and methods for quantitatively measuring molecular changes in the ocular lens

Publications (2)

Publication Number Publication Date
CA2113268A1 true CA2113268A1 (en) 1993-02-04
CA2113268C CA2113268C (en) 1999-01-12

Family

ID=24939928

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002113268A Expired - Lifetime CA2113268C (en) 1991-07-17 1992-07-16 Measuring molecular change in the ocular lens

Country Status (9)

Country Link
US (2) US5203328A (en)
EP (1) EP0597932B1 (en)
JP (1) JPH07500030A (en)
AT (1) ATE158704T1 (en)
AU (1) AU661026B2 (en)
CA (1) CA2113268C (en)
DE (1) DE69222535T2 (en)
ES (1) ES2110007T3 (en)
WO (1) WO1993001745A1 (en)

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DE69222535T2 (en) 1998-03-26
EP0597932A4 (en) 1994-12-07
EP0597932B1 (en) 1997-10-01
US5203328A (en) 1993-04-20
AU661026B2 (en) 1995-07-13
WO1993001745A1 (en) 1993-02-04
DE69222535D1 (en) 1997-11-06
EP0597932A1 (en) 1994-05-25
AU2373392A (en) 1993-02-23
ATE158704T1 (en) 1997-10-15
JPH07500030A (en) 1995-01-05
CA2113268C (en) 1999-01-12
US5582168A (en) 1996-12-10
ES2110007T3 (en) 1998-02-01

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