CA2116764A1 - Immunoreactive Hepatitis C Virus Polypeptide Compositions - Google Patents

Immunoreactive Hepatitis C Virus Polypeptide Compositions

Info

Publication number
CA2116764A1
CA2116764A1 CA 2116764 CA2116764A CA2116764A1 CA 2116764 A1 CA2116764 A1 CA 2116764A1 CA 2116764 CA2116764 CA 2116764 CA 2116764 A CA2116764 A CA 2116764A CA 2116764 A1 CA2116764 A1 CA 2116764A1
Authority
CA
Canada
Prior art keywords
immunoreactive
hepatitis
polypeptide compositions
virus polypeptide
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2116764
Other languages
French (fr)
Other versions
CA2116764C (en
Inventor
Amy J. Weiner
Michael Houghton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25056174&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2116764(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2116764A1 publication Critical patent/CA2116764A1/en
Application granted granted Critical
Publication of CA2116764C publication Critical patent/CA2116764C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
    • C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/82—Hepatitis associated antigens and antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Abstract

This invention relates generally to immunoreactive polypeptide compositions comprising hepatitis type C viral epitopes, methods of using the compositions in immunological applications, and materials and methods for making the compositions.
CA002116764A 1991-09-13 1992-09-11 Immunoreactive hepatitis c virus polypeptide compositions Expired - Lifetime CA2116764C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75957591A 1991-09-13 1991-09-13
US759,575 1991-09-13
PCT/US1992/007683 WO1993006126A1 (en) 1991-09-13 1992-09-11 Immunoreactive hepatitis c virus polypeptide compositions

Publications (2)

Publication Number Publication Date
CA2116764A1 true CA2116764A1 (en) 1993-04-01
CA2116764C CA2116764C (en) 1999-12-07

Family

ID=25056174

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002116764A Expired - Lifetime CA2116764C (en) 1991-09-13 1992-09-11 Immunoreactive hepatitis c virus polypeptide compositions

Country Status (16)

Country Link
US (6) US5756312A (en)
EP (1) EP0608261B1 (en)
JP (5) JPH06511149A (en)
AT (1) ATE228564T1 (en)
AU (1) AU679429B2 (en)
BG (1) BG62973B1 (en)
CA (1) CA2116764C (en)
DE (1) DE69232859T2 (en)
DK (1) DK0608261T3 (en)
ES (1) ES2182822T3 (en)
FI (1) FI112438B (en)
HU (1) HU227510B1 (en)
PL (2) PL171489B1 (en)
RO (1) RO116199B1 (en)
RU (2) RU2136311C1 (en)
WO (1) WO1993006126A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629295B2 (en) 1994-07-25 2009-12-08 Roche Diagnostics Gmbh Determination of a specific immunoglobulin using multiple antigens

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6596476B1 (en) * 1989-12-22 2003-07-22 Abbott Laboratories Hepatitis C assay
CA2116764C (en) * 1991-09-13 1999-12-07 Amy J. Weiner Immunoreactive hepatitis c virus polypeptide compositions
US6297048B1 (en) * 1992-02-04 2001-10-02 Chiron Corporation Hepatitis therapeutics
US6709828B1 (en) 1992-03-06 2004-03-23 N.V. Innogenetics S.A. Process for the determination of peptides corresponding to immunologically important epitopes and their use in a process for determination of antibodies or biotinylated peptides corresponding to immunologically important epitopes, a process for preparing them and compositions containing them
US6667387B1 (en) 1996-09-30 2003-12-23 N.V. Innogenetics S.A. HCV core peptides
CA2142007C (en) * 1992-08-11 2007-10-30 Robert Glen Urban Immunomodulatory peptides
EP1004670B1 (en) 1993-04-27 2012-04-11 Innogenetics N.V. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
US7255997B1 (en) 1993-04-27 2007-08-14 N.V. Innogenetics S.A. Sequences of hepatitis C virus genotypes and their use as therapeutic and diagnostic agents
DE69433160T2 (en) 1993-05-12 2004-07-08 Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville Preserved motif of the hepatitis C virus E2 / NS1 region
US5514539A (en) * 1993-06-29 1996-05-07 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of the envelope 1 gene of 51 isolates of hepatitis C virus and the use of reagents derived from these sequences in diagnostic methods and vaccines
EP0992581B2 (en) 1993-11-04 2011-05-25 Innogenetics N.V. Immunodominant human T-cell epitopes of hepatitis C virus
SG71728A1 (en) 1994-07-29 2000-04-18 Innogenetics Nv Purified hepatitis c virus envelope proteins for diagnostic and therapeutic use
JPH10507643A (en) 1994-10-21 1998-07-28 イノジェネティックス・ナムローゼ・フェンノートシャップ Novel sequences of hepatitis C virus genotypes and their use as prophylactic, therapeutic and diagnostic agents
US6110465A (en) * 1995-06-07 2000-08-29 The United States Of America As Represented By The Department Of Health And Human Services Nucleotide and deduced amino acid sequences of hypervariable region 1 of the envelope 2 gene of isolates of hepatitis C virus and the use of reagents derived from these hypervariable sequences in diagnostic methods and vaccines
US6127116A (en) 1995-08-29 2000-10-03 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US7235394B1 (en) 1995-08-29 2007-06-26 Washington University Functional DNA clone for hepatitis C virus (HCV) and uses thereof
US7045363B2 (en) * 1996-05-01 2006-05-16 Fujirebio Inc. Nucleic acid-bound polypeptide method of producing nucleic acid-bound polypeptide and immunoassay using the polypeptide
US6001613A (en) * 1996-05-24 1999-12-14 Board Of Regents Of University Of Nebraska Plasmid bearing a cDNA copy of the genome of bovine viral diarrhea virus, chimeric derivatives thereof, and method of producing an infectious bovine viral diarrhea virus using said plasmid
CA2269097C (en) 1996-11-08 2007-01-09 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Synthesis and purification of hepatitis c virus-like particles
US6322965B1 (en) * 1997-02-10 2001-11-27 Advanced Life Science Institute, Inc. Chimera antigen peptide
US7338759B1 (en) 1997-03-04 2008-03-04 Washington University HCV variants
US7049428B1 (en) * 1998-03-04 2006-05-23 Washington University HCV variants
ATE482974T1 (en) * 1997-11-06 2010-10-15 Innogenetics Nv MULTIMER PEPTIDES BASED ON THE HEPATITIS C VIRUS ENCLOSURE PROTEIN FOR DIAGNOSTIC USE AND FOR VACCINATION PURPOSES
US6683058B1 (en) 1998-04-15 2004-01-27 Regents Of The University Of California Methods for therapy of neurodegenerative disease of the brain
US6451306B1 (en) 1998-04-15 2002-09-17 The Regents Of The University Of California Methods for therapy of neurodegenerative disease of the brain
US7157435B2 (en) 1998-04-15 2007-01-02 The Regents Of The University Of California Methods for modulation of the effects of aging on the primate brain
US6815431B2 (en) 1998-04-15 2004-11-09 Regents Of The University Of California Methods for therapy of neurodegenerative disease of the brain
US7052830B1 (en) 1998-06-09 2006-05-30 Branch Andrea D Hepatitis C virus peptides and uses thereof
US7108855B2 (en) * 1998-06-24 2006-09-19 Innogenetics N.V. Purified hepatitis C virus envelope proteins for diagnostic and therapeutic use
US6548634B1 (en) * 1998-09-30 2003-04-15 Chiron Corporation Synthetic peptides having FGF receptor affinity
US20030180284A1 (en) * 1998-11-05 2003-09-25 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational and linear epitopes
US7091324B2 (en) 1998-11-05 2006-08-15 Board Of Trustees Of Leland Stanford Junior University Prevention and treatment of HCV infection employing antibodies directed against conformational epitopes
CA2358385C (en) * 1998-12-31 2013-08-06 Chiron Corporation Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
AU2221600A (en) * 1998-12-31 2000-07-31 Chiron Corporation Improved expression of hiv polypeptides and production of virus-like particles
US7935805B1 (en) * 1998-12-31 2011-05-03 Novartis Vaccines & Diagnostics, Inc Polynucleotides encoding antigenic HIV Type C polypeptides, polypeptides and uses thereof
US20030194800A1 (en) * 2001-08-31 2003-10-16 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
WO2000039303A2 (en) 1998-12-31 2000-07-06 Chiron Corporation Modified hiv env polypeptides
EP1535628B1 (en) * 1999-11-24 2013-07-31 Novartis Vaccines and Diagnostics, Inc. Hbv/hcv virus-like particle
US6740323B1 (en) 1999-11-24 2004-05-25 Chiron Corporation HBV/HCV virus-like particle
NZ524070A (en) * 2000-07-19 2008-05-30 Univ California Methods for therapy of neurodegenerative disease of the non-human brain
US6680059B2 (en) * 2000-08-29 2004-01-20 Tripep Ab Vaccines containing ribavirin and methods of use thereof
US7022830B2 (en) * 2000-08-17 2006-04-04 Tripep Ab Hepatitis C virus codon optimized non-structural NS3/4A fusion gene
US6858590B2 (en) * 2000-08-17 2005-02-22 Tripep Ab Vaccines containing ribavirin and methods of use thereof
WO2002013855A2 (en) 2000-08-17 2002-02-21 Tripep Ab Vaccines containing ribavirin and methods of use thereof
WO2002022155A1 (en) 2000-09-13 2002-03-21 Hawaii Biotechnology Group, Inc. Immunogenic composition of hepatitis c and methods of use thereof
CA2634992C (en) 2001-07-05 2012-10-16 Novartis Vaccines And Diagnostics, Inc. Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof
US20030198621A1 (en) * 2001-07-05 2003-10-23 Megede Jan Zur Polynucleotides encoding antigenic HIV type B and/or type C polypeptides, polypeptides and uses thereof
US20030170614A1 (en) * 2001-08-31 2003-09-11 Megede Jan Zur Polynucleotides encoding antigenic HIV type B polypeptides, polypeptides and uses thereof
AR045702A1 (en) * 2001-10-03 2005-11-09 Chiron Corp COMPOSITIONS OF ASSISTANTS.
WO2005007808A2 (en) 2003-05-15 2005-01-27 Chiron Corporation Hiv polynucleotides and polypeptides derived from botswana mj4
US20050202036A1 (en) * 2003-07-22 2005-09-15 Branch Andrea D. Alternate reading frame polypeptides drived from hepatitis C and methods of their use
US20050130131A1 (en) * 2003-08-14 2005-06-16 California Institute Of Molecular Medicine Method for isolation and replication of infectious human hepatitis-C virus
US8124747B2 (en) 2003-08-29 2012-02-28 Innogenetics HCV clade and prototype sequences thereof
CA2585672A1 (en) 2004-11-01 2006-05-11 Novartis Vaccines And Diagnostics Inc. Combination approaches for generating immune responses
CA2618429A1 (en) * 2005-05-25 2007-03-22 Tripep Ab A hepatitis c virus non-structural ns3/4a fusion gene
WO2007084568A2 (en) 2006-01-17 2007-07-26 Health Research, Inc. Heteroduplex tracking assay
EP2185195A2 (en) * 2007-08-16 2010-05-19 Tripep Ab Immunogen platform
EP2201023A2 (en) * 2007-09-14 2010-06-30 GENimmune N.V. Affinity tag
US8268783B2 (en) 2007-09-28 2012-09-18 Portola Pharmaceuticals, Inc. Antidotes for factor Xa inhibitors and methods of using the same
ES2796623T3 (en) 2007-09-28 2020-11-27 Portola Pharm Inc Antidotes to Factor Xa Inhibitors and Procedures for Using Them
WO2009130588A2 (en) * 2008-04-22 2009-10-29 Tripep Ab Immunogen platform
US20100104555A1 (en) * 2008-10-24 2010-04-29 The Scripps Research Institute HCV neutralizing epitopes
WO2010148117A1 (en) 2009-06-17 2010-12-23 Scantibodies Laboratory, Inc. Therapeutic and diagnostic affinity purified specific polyclonal antibodies
CN102625712B (en) 2009-07-15 2017-07-25 博尔托拉制药公司 Unit dose formulations and its application method for the antidote of factor XA inhibitor
SG10201605500TA (en) 2011-07-06 2016-08-30 Novartis Ag Cationic oil-in-water emulsions
MX350198B (en) 2011-07-06 2017-08-30 Novartis Ag Oil-in-water emulsions that contain nucleic acids.
US8609355B2 (en) 2011-07-26 2013-12-17 Indicator Systems International, Inc. Assays for the detection of microbes
FR2984328B1 (en) 2011-12-20 2016-12-30 Bio-Rad Innovations METHOD FOR DETECTING HEPATITIS C VIRUS INFECTION
US9228006B2 (en) 2012-03-16 2016-01-05 University Health Network Methods and compositions for modulating Toso activity
RU2520710C1 (en) * 2012-12-10 2014-06-27 Государственное бюджетное образовательное учреждение высшего профессионального образования "Челябинская государственная медицинская академия" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ЧелГМА Минздравсоцразвития России) Method for prediction of persistence of oncogenic human papilloma virus in cervical epithelium
US20150250853A1 (en) 2014-03-07 2015-09-10 University Health Network Methods and compositions for modifying the immune response
RU2675108C2 (en) * 2015-06-15 2018-12-17 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт биомедицинской химии имени В.Н. Ореховича" (ИБМХ) Composition based on synthetic peptides and lipids for c hepatitis vaccine
US10287338B2 (en) 2015-07-10 2019-05-14 Miran NERSISSIAN Factor VIII protein compositions and methods of treating of hemophilia A
WO2017066719A2 (en) 2015-10-14 2017-04-20 Research Institute At Nationwide Children's Hospital Hu specific interfering agents
AU2018206560A1 (en) 2017-01-04 2019-07-18 Research Institute At Nationwide Children's Hospital Antibody fragments for the treatment of biofilm-related disorders
EP3565589A1 (en) 2017-01-04 2019-11-13 Research Institute at Nationwide Children's Hospital Dnabii vaccines and antibodies with enhanced activity
WO2018170178A1 (en) 2017-03-15 2018-09-20 Research Institute At Nationwide Children's Hospital Composition and methods for disruption of bacterial biofilms without accompanying inflammation
AU2020311897A1 (en) 2019-07-08 2022-02-03 Research Institute At Nationwide Children's Hospital Antibody compositions for disrupting biofilms

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3400079A1 (en) * 1984-01-03 1985-07-11 Röhm GmbH, 6100 Darmstadt WATER-SPREADING PLASTIC MATERIAL, METHOD FOR THE PRODUCTION THEREOF AND USE AS GLAZING AND ROOFING MATERIAL
NZ219516A (en) * 1987-02-10 1991-02-26 Wellcome Found Fusion proteins of hbcag (hepatitis b virus core antigen)
US5350671A (en) * 1987-11-18 1994-09-27 Chiron Corporation HCV immunoassays employing C domain antigens
NZ227011A (en) * 1987-11-18 1992-03-26 Chiron Corp Non-a, non-b-hepatitis (hepatitis c) antigens, proteins, nucleotide sequences, vaccines and kits
UA50829C2 (en) * 1989-03-17 2002-11-15 Чірон Корпорейшн Polynucleotide, vector, cells, expressing system, polypeptides, monoclonal antibodies, preparation of polyclonal antibodies, nucleotide probe, analytic kits, method for detecting nucleic acids, methods for immunoassay, vaccine, method for production of antibodies
ATE211772T1 (en) * 1989-05-18 2002-01-15 Chiron Corp NANBV DIAGNOSTICS: POLYNUCLEOTIDES SUITABLE FOR SERIAL EXAMINATIONS FOR HEPATITIS C VIRUS
US5372928A (en) * 1989-09-15 1994-12-13 Chiron Corporation Hepatitis C virus isolates
CA2065287C (en) * 1989-09-15 1999-12-21 Tatsuo Miyamura New hcv isolates
DE59109271D1 (en) * 1990-11-03 2006-04-27 Dade Behring Marburg Gmbh HCV-specific peptides, means for this and their use
CA2116764C (en) * 1991-09-13 1999-12-07 Amy J. Weiner Immunoreactive hepatitis c virus polypeptide compositions

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7629295B2 (en) 1994-07-25 2009-12-08 Roche Diagnostics Gmbh Determination of a specific immunoglobulin using multiple antigens

Also Published As

Publication number Publication date
US5670152A (en) 1997-09-23
US5670153A (en) 1997-09-23
FI941199A0 (en) 1994-03-14
US6303292B1 (en) 2001-10-16
CA2116764C (en) 1999-12-07
PL171972B1 (en) 1997-07-31
HU9400741D0 (en) 1994-06-28
ES2182822T3 (en) 2003-03-16
JP2004073207A (en) 2004-03-11
DK0608261T3 (en) 2003-03-17
BG62973B1 (en) 2000-12-29
FI112438B (en) 2003-12-15
JP2005176853A (en) 2005-07-07
JP2002167336A (en) 2002-06-11
BG98653A (en) 1995-05-31
FI941199A (en) 1994-04-27
DE69232859T2 (en) 2003-04-10
ATE228564T1 (en) 2002-12-15
US5728520A (en) 1998-03-17
AU679429B2 (en) 1997-07-03
HU227510B1 (en) 2011-07-28
HUT67342A (en) 1995-03-28
RU2136311C1 (en) 1999-09-10
EP0608261A4 (en) 1995-03-15
RU2212899C2 (en) 2003-09-27
EP0608261B1 (en) 2002-11-27
DE69232859D1 (en) 2003-01-16
EP0608261A1 (en) 1994-08-03
AU2643692A (en) 1993-04-27
JP4353905B2 (en) 2009-10-28
WO1993006126A1 (en) 1993-04-01
RO116199B1 (en) 2000-11-30
US5756312A (en) 1998-05-26
JP2008133301A (en) 2008-06-12
JPH06511149A (en) 1994-12-15
US5766845A (en) 1998-06-16
PL171489B1 (en) 1997-05-30

Similar Documents

Publication Publication Date Title
CA2116764A1 (en) Immunoreactive Hepatitis C Virus Polypeptide Compositions
CA2110058A1 (en) Hepatitis c virus (hcv) polypeptides
EP0992580A3 (en) Immunodominant human T-cell epitopes of Hepatitis C virus
RU94024561A (en) IMMUNORACTIVE COMPOSITIONS, METHOD FOR PREPARING THE COMPOSITION, METHODS FOR OBTAINING AND DETECTING ANTIBODIES, DNA SET, HOST CELL, METHOD OF OBTAINING PROTEIN
CA2103887A1 (en) Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
AU7565694A (en) Methods and compositions for the large scale production of recombinant adeno-associated virus
NZ512056A (en) HBV core antigen particles with multiple immunogenic components attached via peptide ligands
IL90058A0 (en) Hiv envelope peptide,vaccines containing it,monoclonal antibodies directed against said peptide and pharmaceutical compositions containing said antibodies
AU2370592A (en) Epitopes of the env protein of the hepatitis c virus
EP0333071A3 (en) Polypeptides, methods for their preparation, pharmaceutical compositions comprising them and use
EP0518313A3 (en) Gene of hepatitis c virus or fragment thereof, polypeptide encoded by the same
AU1522792A (en) Multiple hepatitis b virus surface proteins which form particles
WO1994021812A3 (en) Hepatitis b escape mutant specific binding molecules
EP0600000A4 (en) Hepatitis c assay utilizing recombinant antigens from ns5 region.
AU7909391A (en) Epitopes of the pre-s region of hepatitis b virus surface antigen
CA2304255A1 (en) Hepatitis b virus polypeptides
AU7387291A (en) Cellular binding protein having affinity for the regulatory region of the human papilloma virus type 18
GR3036125T3 (en) Recombinant proteins having the immunoreactivity of Hepatitis B virus e antigens (HBeAg), method for their production and their application in immunoassays and as vaccines.
IE880242L (en) Hepatitis b virus antigens.
CA2080355A1 (en) Isolated Viral Protein Cytokine Antagonists
AU6991098A (en) Immunoreactive antigens of hepatitis E virus
ZA912581B (en) Hepatitis c virus epitopes
AU2955789A (en) Vaccine containing polypeptides derived from the envelope gene of human immunodeficiency virus type 1
AU8225891A (en) Anti-human immunodeficiency virus agent
IE892694L (en) Monoclonal antibody against hiv virus

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry