CA2117060C - Safety cannula - Google Patents
Safety cannula Download PDFInfo
- Publication number
- CA2117060C CA2117060C CA002117060A CA2117060A CA2117060C CA 2117060 C CA2117060 C CA 2117060C CA 002117060 A CA002117060 A CA 002117060A CA 2117060 A CA2117060 A CA 2117060A CA 2117060 C CA2117060 C CA 2117060C
- Authority
- CA
- Canada
- Prior art keywords
- cartridge
- cannula
- needle cannula
- hub
- needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/04—Access sites having pierceable self-sealing members
- A61M39/045—Access sites having pierceable self-sealing members pre-slit to be pierced by blunt instrument
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M39/14—Tube connectors; Tube couplings for connecting tubes having sealed ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2414—Ampoule inserted into the ampoule holder from the side
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M5/2455—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened
- A61M5/2466—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase
- A61M2005/247—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic with sealing means to be broken or opened by piercing without internal pressure increase with fixed or steady piercing means, e.g. piercing under movement of ampoule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1027—Quick-acting type connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1033—Swivel nut connectors, e.g. threaded connectors, bayonet-connectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/10—Tube connectors; Tube couplings
- A61M2039/1072—Tube connectors; Tube couplings with a septum present in the connector
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S604/00—Surgery
- Y10S604/905—Aseptic connectors or couplings, e.g. frangible, piercable
Abstract
A coupling system (10) for transferring fluids from a medicament-con-taining cartridge to an injection site comprises a fluid flow channel, a blunt cannula (16), defining the distal end of the fluid flow channel (14), a needle cannula (18) defining the proximal end of the fluid flow channel (12) and means for fixedly connecting the needle cannula (18) to the blunt cannula (16).
Description
r0 94/01170 - 1 - PCT/US93/06199 SAFETY CANNULA
BACKGROUND OF THE INVENTION
S
1. Field of Invention This invention relates to coupling systems for transferring materials from one flow conduit to another.
BACKGROUND OF THE INVENTION
S
1. Field of Invention This invention relates to coupling systems for transferring materials from one flow conduit to another.
2. Description of the Prior Art Disposable medicament-containing cartridge-needle units for use in conjunction with reusable hypodermic syringe holders are well known in the art. Such cartridges conventionally feature a cylindrical body closed at the proximal end with a flexible piston slidable within the bore of the cartridge and closed at the distal necked-down end with a diaphragm secured to the cartridge by a crimped-on metal collar. The necked-down distal end conventionally is fitted with a steel needle/needle hub unit and a needle sheath. Such needle/needle hub units have, minimally, a sharp end, typical of the type associated with hypodermic syringes.
Such cartridge-needle units can be used in conjunction with reusable syringe holders which allow the user to avoid handling the cartridge-needle unit when the needle is exposed. Nevertheless, health care workers are especially susceptible to accidental and potentially infectious, and indeed, on occasion, possibly fatal, needle strikes due to the careless handling and/or disposing of the cartridge-needle unit after use. The consequences to health care workers of strikes from needles contaminated with various infectious diseases such as hepatitis or AIDS can be particularly severe.
The frequency of such accidental needle strikes in the United States is surprisingly great, and has been estimated to be approximately one million needle strikes per year. Moreover, the cost to health care organizations for the testing of health care workers accidentally stricken by used needles is a 2~~. ~ ~J60 WO 94/01170 - 2 - PCf/US93/061c~
significant burden on health care costs. Therefore, it would be desirable to further protect health care workers by providing medicament containing cartridges without having to expose the user to the needle commonly associated with such cartridges.
In response to the "accidental needle strike"
situation, numerous devices have been developed which typically shield or cover the sharp needle tip. One recently developed system, as described in PCT/US89/00273, comprises a pre-slit injection site specifically designed to receive a blunt cannula. Commercially available under the InterLink trademark, this pre-slit injection site and blunt cannula have been adapted for intravenous administration as described in pending U.S. and foreign patent applications. One of the key features of this system is the elimination of traditional "sharp" needles which are used in numerous procedures. For example, as described in PCT/US90/01350, the blunt cannula device is depicted in a press-fit combination with a syringe of known construction. Rather than using a traditional needle, the blunt cannula device is attached to the syringe and then inserted through the pre-slit injection site located in an IV tubing line. The content of the syringe is then delivered into the IV line. Once the content is delivered, the cannula is withdrawn from the site and properly disposed.
Hence, the administration of the syringe content, through an ~7IV line, can now be completed without the use of a standard needle.
Hence, it would be highly desirable to provide conventional disposable medicament cartridges adaptable to such blunt cannulae and useable with such pre-slit injection sites.
SUMMARY OF THE INVENTION
In accordance with this invention, an improved coupling system is provided for transferring fluids from a
Such cartridge-needle units can be used in conjunction with reusable syringe holders which allow the user to avoid handling the cartridge-needle unit when the needle is exposed. Nevertheless, health care workers are especially susceptible to accidental and potentially infectious, and indeed, on occasion, possibly fatal, needle strikes due to the careless handling and/or disposing of the cartridge-needle unit after use. The consequences to health care workers of strikes from needles contaminated with various infectious diseases such as hepatitis or AIDS can be particularly severe.
The frequency of such accidental needle strikes in the United States is surprisingly great, and has been estimated to be approximately one million needle strikes per year. Moreover, the cost to health care organizations for the testing of health care workers accidentally stricken by used needles is a 2~~. ~ ~J60 WO 94/01170 - 2 - PCf/US93/061c~
significant burden on health care costs. Therefore, it would be desirable to further protect health care workers by providing medicament containing cartridges without having to expose the user to the needle commonly associated with such cartridges.
In response to the "accidental needle strike"
situation, numerous devices have been developed which typically shield or cover the sharp needle tip. One recently developed system, as described in PCT/US89/00273, comprises a pre-slit injection site specifically designed to receive a blunt cannula. Commercially available under the InterLink trademark, this pre-slit injection site and blunt cannula have been adapted for intravenous administration as described in pending U.S. and foreign patent applications. One of the key features of this system is the elimination of traditional "sharp" needles which are used in numerous procedures. For example, as described in PCT/US90/01350, the blunt cannula device is depicted in a press-fit combination with a syringe of known construction. Rather than using a traditional needle, the blunt cannula device is attached to the syringe and then inserted through the pre-slit injection site located in an IV tubing line. The content of the syringe is then delivered into the IV line. Once the content is delivered, the cannula is withdrawn from the site and properly disposed.
Hence, the administration of the syringe content, through an ~7IV line, can now be completed without the use of a standard needle.
Hence, it would be highly desirable to provide conventional disposable medicament cartridges adaptable to such blunt cannulae and useable with such pre-slit injection sites.
SUMMARY OF THE INVENTION
In accordance with this invention, an improved coupling system is provided for transferring fluids from a
-3-medicament-containing cartridge to an injection site which reduces the possibility of accidental needle strikes.
More specifically, this invention provides an improved coupling system for transferring fluids from a medicament-cor.~taining cartridge to a pre-slit injection site, the cou~~ling system comprising a fluid flow channel, a blunt cannula defining the distal end of the fluid flow channel, a needle cannula defining the proximal end of the fluid flow channel, and means for fixedly connecting the needle cannula to the blunt cannula. In a preferred embodiment, the coupling system includes a hub comprising the blunt cannula and a sleeve portion which extends around and beyond the proximal end of the needle cannula.
It is an advantageous feature of this invention that an improved coupling system is provided for commercially available medicament-containing cartridges which can be used safely and effectively without exposing the user to the needle cannula. This reduces the susceptibility of health care workers to accidental needle strikes.
It is another advantageous feature of this invention that a safety coupling device is provided that may not be subject to a potentially lengthy approval process before the US Food and Drug Administration.
Other advantages will become readily apparent upon reference to the following description of preferred embodiments when read in light of the accompanying drawings.
According to an aspect of the invention, a coupling system for transferring fluids from a medicament-containing cartridge to an injection site, said coupling system comprising:
~1 17060 -3a a fluid flow channel having proximal and distal ends;
a blunt cannula defining the distal end of said fluid flow channel;
a needle cannula defining the proximal end of said fluid flow channel; and means for fixedly connecting said needle cannula to said blunt car..nula .
According' to another aspect of the invention, a coupling system for transferring fluids from a medicament-containing cartridge to an injection site, said coupling system comprising;
a fluid flow channel having a proximal and distal ends;
a needle cannula defining the proximal end of said fluid flow channel;
a hub corr~prising a blunt cannula portion defining the distal end of said fluid flow channel and a sleeve portion which extends beyond the proximal end of said needle cannula; and means for fixedly connecting said needle cannula to said hub.
According to yet another aspect of the invention, a coupling system-cartridge assembly comprising in combination, (1) a cartridge, comprising a hollow body prefilled with a medication having a sealed diaphragm on the distal end thereof and a piston axially and reciprocally slidable through the interior of said body; and (2) a coupling system for transferring fluids from said cartridge to an injection site, said coupling system comprlslng:
~1 17060 -3 b-a fluid flow channel having proximal and distal ends;
a needle cannula defining the proximal end of said fluid flow channel; and a hub comprising a blunt cannula portion defining the distal enc. of said fluid flow channel and a sleeve portion which extends beyond the proximal end of said needle cannula. wherein said hub is adapted to be attached to said cartridge by snapping said sleeve over the distal end of said cartridge.
According to a further aspect of the invention, a coupling system-cartridge-syringe holder assembly comprising in combination, (1) a syringe holder comprising a frame, a clamp and a plunger element containing a piston stem;
(2) a cartridge loaded into the frame of said syringe holder, said cartridge loaded into the frame of said syringe holder, said cartridge comprising a hollow body filled with a medication, a sealed diaphragm on the distal end thereof and a piston axially and reciprocally slidable through the interior of said body; and (3) a coupling system for transferring fluids from said cartridge to an injection site, said coupling system comprising:
a fluid flow channel having proximal and distal ends;
a needle cannula defining the proximal end of said fluid flow channel;
a hub attached to the distal end of said cartridge comprising a blunt cannula portion defining the distal end of said fluid flow channel and a sleeve portion which extends beyond the proximal end of said needle cannula;
-3c wherein ;aid cartridge can be advanced distally through said holder by rotating said clamp such that the proximal end of said needle cannula penetrates said diaphragm, anc!
said piston stem can be connected to said piston and actuated to drive said piston through said cartridge and expulse the fluid contents of said cartridge through said fluid flow channel into an injection site.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is an exploded cross-section showing a preferred embodiment of the coupling system of this invention.
Fig. 2 is a cross-section showing a coupling system of this invention in an assembled relation and a pre-slit injection site.
Fig. 3 shows in cross-section a coupling system of this invention. in cambination with a conventional medication-containing cartridge.
A
2 ~. ~.'~ ~ 6 0 ~~' ~ 94/01170 - 4 - PCT/US93/0619"'"~~
Fig. 4 is an exploded view of a syringe holder which can be used in conjunction with the coupling system-cartridge combination of this invention.
DESCRIPTION OF PREFERRED EMBODIMENTS
While this invention is described hereinafter particularly with respect to a preferred embodiment, i.e., a coupling system for transferring fluids from a medicament-containing cartridge to a pre-slit injection site, it also finds utility in other coupling systems for transferring fluid materials from one flow conduit to another.
With reference to the drawings, a coupling system of this invention, represented by 10, is intended for use in combination with a conventional disposable medicament-containing cartridge. The coupling system includes a fluid flow channel, having a proximal end 12 and a distal end 14, a blunt cannula 16 defining the distal end of the fluid flow channel, a needle cannula 18 defining the proximal end of the fluid flow channel, and means described hereinafter for fixedly connecting the needle cannula to the blunt cannula.
In a preferred embodiment, the coupling system comprises a hub 20 comprising the blunt cannula 16 defining the distal end of the fluid flow channel and a sleeve portion 22 which extends around and beyond the proximal end of the needle cannula when assembled. It is possible to assemble the coupling system at the manufacturer's site, thereby virtually eliminating user exposure to needle cannula 12.
Needle cannula 12 can be a single or double sharp ended needle cannula of the type commonly associated with hypodermic syringes. A needle cannula of the single ended type, as shown in Fig. 1, is preferred. The needle cannula preferably is fabricated of stainless steel.
For use with conventional cartridges, e.g., commercially available CarpujectTM sterile cartridges, the radius r of sleeve 22 is about 5 mm and the distance x between the end of sleeve 22 and the proximal end of needle cannula 18 preferably is at least about 2 mm, more preferably 3mm, so that the proximal end of the needle cannula is adequately shielded when the coupling system is not attached to the cartridge. The distal end of the needle cannula 18 can be flush with the distal 5 end of the blunt cannula. However, to reduce the undesirable possibility of the needle cannula extending beyond the distal end of the blunt cannula due to manufacturing tolerances, a clearance Y of at least about 0.5 mm, and preferably, of about 1 mm can be provided.
Blunt cannula 16 is tapered at its distal end to engage an injection site. The blunt cannula 16 preferably is an integral part of hub 20. The specifics of the design of the tapered blunt cannula end portion of hub 20 can be ascertained with reference to PCT/US89/000273, PCT/US90/01350, which describe tapered blunt cannulae for use with pre-slit injection sites.
Various means can be employed for fixedly connecting the needle cannula to the blunt cannula and/or the hub comprising the blunt cannula. For example, the fluid flow path inside the blunt cannula can be tapered such that the needle cannula can be 2C inserted into and adhesively connected to the blunt cannula.
Suitable adhesives include, e.g., an epoxy based resin, and can be applied to the outside surface of the needle cannula prior to insertion into the hub. Alternatively, the needle cannula can be inserted into the blunt cannula or hub and the blunt cannula or hub can be melted or welded to connect the needle cannula to the blunt cannula. In another embodiment, the connecting means can take the form of an insert 24 which can be sized to fit through sleeve 22 and snap into mating portion 26 in the middle section of hub 20.
A removable cover sheath 28 can be provided to surround blunt cannula 16 during storage and handling to preserve the sterility of the cannula. Cover sheath 28 can be snapped into engagement with the hub to surround and protect the outwardly projecting distal end of blunt cannula 16.
Disposable medication cartridge 30 is of: a conventional design and includes a hollow, transparent bod~~ which is prefilled with a supply of fluid medication or the like. Such cartridges currently are in widespread commercial use. Cartridge 30 includes a head 32 and a cylindrical body 34 which are coextensively joined together at a relatively narrow neck 36. A metallic end cap 38 covers a sealed diaphragm 40 which extends across cartridge 30 to prevent contamination and leakage of the fluid contents. A piston 42 is sized to be received in and slidable axially and reciprocally through the interior of cartridge 30.
Piston 42 is formed from a relatively dense resilient material, e.g., rubber, and can be moved distally through cartridge 30 for expulsing the fluid contents of the cartridge via the needle cannula 18. A screw-threaded rod 44 can be connected to the piston 42 so as to project outwardly from the end of piston 42.
Screw-threaded rod 44 can be mated to a screw-threaded piston stem of an associated holder to complete a piston assembly for controlling the movement of piston 42 through the interior of cartridge 30. It is contemplated that other means known in the art can be employed for attaching the rod to the piston stem.
The above-described medicament-containing cartridges are designed for use in conjunction with reusable or other disposable syringe holders. Exemplary useful syringe holders are described, for example, in Hadtke, U .S. Patent 4,585,445 and EPO 485,028.
Such a syringe holder 46 as depicted in Fig. 4, can comprise a cylindrical frame 48, a clamp 50, and a plunger element 52 containing a piston stem 58.
In preferred embodiments, the coupling system of this invention is practiced in conjunction with a pre-slit injection site as described in PCT/US89/00273, PCT/US90/01350 and depicted in Fig. 2. Injection site 62 has a cylindrical housing 64, a first end 66, a second end 68, and a hollow cylindrical fluid flow member 70 which can slidably engage a receiving member, e.g., the housing of a catheter, thereby providing a sterile fluid flow coupling. Internal male iuer threads 72, shown to be carried by housing 64 to adjacent the second end 68, engage a flange member knot :illustrated) when the injection site is rotated. The injection site 62 contains a res~alable septum 74 formed of, for example, a latex, synthetic rubber or thermoplastic elastomer. The septum 74 has either a partial or complete opening or slit 76.
The hub 20 preferably is attachable to the cartridge by snapping sleeve portion 22 over the distal end of the cartridge to engage the metal cap 38. In order to obtain the requisite sterile seal and flexibility, the hub preferably is fabricated of a plastic material such as po:Lyethylene or polypropylene, or a polypropylene copolymer containing a minor amount of, e.g., low density polyethylene, to increase the impact strength of the polymer. An example of the latter copolymer is Pro-fax 8523~~"', available from Hirr~ont Incorporated.
such copolymer is particularly preferred when the hub is prepared by conventional injection molding techniques.
The hub 20 can be optionally provided with a first set of fins 54 at the base of the blunt cannula for manufacturing purposes. Such fins may also provide a sense of resistance alerting the user, to prevent the cannula l6 and/or hub 20 from being penetrated too deeply into the port of an injection site as shown in Fig. 2. The hub can optionally be provided With a second set of fins 56 at the base of the sleeve to provide a stop for the blunt cannula sheath.
The coupling system.l0 of this invention can be prepared by inserting a needle cannula 18 through the insert 24. The insert 24 is preferably fabricated of an injection moldable plastic, e.g., polycarbonate or polypropylene, and can be pre-sterilized or pre-treated for improved adhesion, e.g., by corona discharge treatment. An adhesive, e.g., a UV
' curable epoxy resin, can be applied to the needle/insert interface and, subsequently, the resin can be cured. The coupling system 10 preferably is sterlizable such as by means of radiation, steam or ethylene oxide. The needle cannula-insert subassembly can then be press fit through the sleeve into the hub 20. The sheath 28 can then be fitted over the 211'~~60 WO 94/01170 - a - PCT/US93/061R~..
hub 20, and the coupling system-sheath subassembly can be snap fitted over the necked down end of the cartridge 30.
In use, the coupling system 10 of this invention operates in conjunction with conventional medicament-s containing cartridges, reusable syringe holders and injection sites during and after administration of an injection as follows. In the injection state, the prefilled medication cartridge 30 fitted with the coupling system 10 of this invention is loaded into cylindrical frame 48 of an assembled reusable syringe holder 46 such as described above so that blunt cannula 16 covered by sheath 28 extends distally outward from the frame. Cartridge 30 is then advanced by a health care worker distally through the holder by rotating clamping element 50 until the inwardly extending proximal end of needle cannula 12 penetrates sealed diaphragm 40 of cartridge 30.
Next, sheath 28 is removed to expose the outwardly extending distal end of blunt cannula 16. A screw threaded piston stem 58 is connected to piston 42 at the screw-threaded rod 44 thereof. The blunt cannula 16 is inserted into a pre-slit injection site, such as described above, and an axially and distally directed force is applied by the health care worker to piston stem 52, via actuation button 60. The distal force is transferred from piston stem 58 to piston 44 to drive the piston through medicament-containing cartridge 30 and thereby expulse the fluid contents of the cartridge 30 via needle cannula 18 through the fluid flow channel and into the fluid flow member 70 of the pre-slit injection site 62. After injection, the blunt cannula 16 is removed from the injection site. Subsequently, the plunger rod 44 is unscrewed from the piston thread and pulled proximally back, the clamp 50 is rotated to free the cartridge 30 and the cartridge unit is disposed of in an appropriate manner, the needle cannula 18 being safely covered by the hub 20, sleeve 22 and/or blunt cannula 16 during the entire procedure, thus reducing the possibility of accidental needle strikes.
The invention has been described in detail with particular reference to certain preferred embodiments thereof, '"7 94/01170 - 9 - PCT/US93/06199 but it will be understood that variations and modifications can be effected within the spirit and scope of the invention.
More specifically, this invention provides an improved coupling system for transferring fluids from a medicament-cor.~taining cartridge to a pre-slit injection site, the cou~~ling system comprising a fluid flow channel, a blunt cannula defining the distal end of the fluid flow channel, a needle cannula defining the proximal end of the fluid flow channel, and means for fixedly connecting the needle cannula to the blunt cannula. In a preferred embodiment, the coupling system includes a hub comprising the blunt cannula and a sleeve portion which extends around and beyond the proximal end of the needle cannula.
It is an advantageous feature of this invention that an improved coupling system is provided for commercially available medicament-containing cartridges which can be used safely and effectively without exposing the user to the needle cannula. This reduces the susceptibility of health care workers to accidental needle strikes.
It is another advantageous feature of this invention that a safety coupling device is provided that may not be subject to a potentially lengthy approval process before the US Food and Drug Administration.
Other advantages will become readily apparent upon reference to the following description of preferred embodiments when read in light of the accompanying drawings.
According to an aspect of the invention, a coupling system for transferring fluids from a medicament-containing cartridge to an injection site, said coupling system comprising:
~1 17060 -3a a fluid flow channel having proximal and distal ends;
a blunt cannula defining the distal end of said fluid flow channel;
a needle cannula defining the proximal end of said fluid flow channel; and means for fixedly connecting said needle cannula to said blunt car..nula .
According' to another aspect of the invention, a coupling system for transferring fluids from a medicament-containing cartridge to an injection site, said coupling system comprising;
a fluid flow channel having a proximal and distal ends;
a needle cannula defining the proximal end of said fluid flow channel;
a hub corr~prising a blunt cannula portion defining the distal end of said fluid flow channel and a sleeve portion which extends beyond the proximal end of said needle cannula; and means for fixedly connecting said needle cannula to said hub.
According to yet another aspect of the invention, a coupling system-cartridge assembly comprising in combination, (1) a cartridge, comprising a hollow body prefilled with a medication having a sealed diaphragm on the distal end thereof and a piston axially and reciprocally slidable through the interior of said body; and (2) a coupling system for transferring fluids from said cartridge to an injection site, said coupling system comprlslng:
~1 17060 -3 b-a fluid flow channel having proximal and distal ends;
a needle cannula defining the proximal end of said fluid flow channel; and a hub comprising a blunt cannula portion defining the distal enc. of said fluid flow channel and a sleeve portion which extends beyond the proximal end of said needle cannula. wherein said hub is adapted to be attached to said cartridge by snapping said sleeve over the distal end of said cartridge.
According to a further aspect of the invention, a coupling system-cartridge-syringe holder assembly comprising in combination, (1) a syringe holder comprising a frame, a clamp and a plunger element containing a piston stem;
(2) a cartridge loaded into the frame of said syringe holder, said cartridge loaded into the frame of said syringe holder, said cartridge comprising a hollow body filled with a medication, a sealed diaphragm on the distal end thereof and a piston axially and reciprocally slidable through the interior of said body; and (3) a coupling system for transferring fluids from said cartridge to an injection site, said coupling system comprising:
a fluid flow channel having proximal and distal ends;
a needle cannula defining the proximal end of said fluid flow channel;
a hub attached to the distal end of said cartridge comprising a blunt cannula portion defining the distal end of said fluid flow channel and a sleeve portion which extends beyond the proximal end of said needle cannula;
-3c wherein ;aid cartridge can be advanced distally through said holder by rotating said clamp such that the proximal end of said needle cannula penetrates said diaphragm, anc!
said piston stem can be connected to said piston and actuated to drive said piston through said cartridge and expulse the fluid contents of said cartridge through said fluid flow channel into an injection site.
BRIEF DESCRIPTION OF THE DRAWINGS
Fig. 1 is an exploded cross-section showing a preferred embodiment of the coupling system of this invention.
Fig. 2 is a cross-section showing a coupling system of this invention in an assembled relation and a pre-slit injection site.
Fig. 3 shows in cross-section a coupling system of this invention. in cambination with a conventional medication-containing cartridge.
A
2 ~. ~.'~ ~ 6 0 ~~' ~ 94/01170 - 4 - PCT/US93/0619"'"~~
Fig. 4 is an exploded view of a syringe holder which can be used in conjunction with the coupling system-cartridge combination of this invention.
DESCRIPTION OF PREFERRED EMBODIMENTS
While this invention is described hereinafter particularly with respect to a preferred embodiment, i.e., a coupling system for transferring fluids from a medicament-containing cartridge to a pre-slit injection site, it also finds utility in other coupling systems for transferring fluid materials from one flow conduit to another.
With reference to the drawings, a coupling system of this invention, represented by 10, is intended for use in combination with a conventional disposable medicament-containing cartridge. The coupling system includes a fluid flow channel, having a proximal end 12 and a distal end 14, a blunt cannula 16 defining the distal end of the fluid flow channel, a needle cannula 18 defining the proximal end of the fluid flow channel, and means described hereinafter for fixedly connecting the needle cannula to the blunt cannula.
In a preferred embodiment, the coupling system comprises a hub 20 comprising the blunt cannula 16 defining the distal end of the fluid flow channel and a sleeve portion 22 which extends around and beyond the proximal end of the needle cannula when assembled. It is possible to assemble the coupling system at the manufacturer's site, thereby virtually eliminating user exposure to needle cannula 12.
Needle cannula 12 can be a single or double sharp ended needle cannula of the type commonly associated with hypodermic syringes. A needle cannula of the single ended type, as shown in Fig. 1, is preferred. The needle cannula preferably is fabricated of stainless steel.
For use with conventional cartridges, e.g., commercially available CarpujectTM sterile cartridges, the radius r of sleeve 22 is about 5 mm and the distance x between the end of sleeve 22 and the proximal end of needle cannula 18 preferably is at least about 2 mm, more preferably 3mm, so that the proximal end of the needle cannula is adequately shielded when the coupling system is not attached to the cartridge. The distal end of the needle cannula 18 can be flush with the distal 5 end of the blunt cannula. However, to reduce the undesirable possibility of the needle cannula extending beyond the distal end of the blunt cannula due to manufacturing tolerances, a clearance Y of at least about 0.5 mm, and preferably, of about 1 mm can be provided.
Blunt cannula 16 is tapered at its distal end to engage an injection site. The blunt cannula 16 preferably is an integral part of hub 20. The specifics of the design of the tapered blunt cannula end portion of hub 20 can be ascertained with reference to PCT/US89/000273, PCT/US90/01350, which describe tapered blunt cannulae for use with pre-slit injection sites.
Various means can be employed for fixedly connecting the needle cannula to the blunt cannula and/or the hub comprising the blunt cannula. For example, the fluid flow path inside the blunt cannula can be tapered such that the needle cannula can be 2C inserted into and adhesively connected to the blunt cannula.
Suitable adhesives include, e.g., an epoxy based resin, and can be applied to the outside surface of the needle cannula prior to insertion into the hub. Alternatively, the needle cannula can be inserted into the blunt cannula or hub and the blunt cannula or hub can be melted or welded to connect the needle cannula to the blunt cannula. In another embodiment, the connecting means can take the form of an insert 24 which can be sized to fit through sleeve 22 and snap into mating portion 26 in the middle section of hub 20.
A removable cover sheath 28 can be provided to surround blunt cannula 16 during storage and handling to preserve the sterility of the cannula. Cover sheath 28 can be snapped into engagement with the hub to surround and protect the outwardly projecting distal end of blunt cannula 16.
Disposable medication cartridge 30 is of: a conventional design and includes a hollow, transparent bod~~ which is prefilled with a supply of fluid medication or the like. Such cartridges currently are in widespread commercial use. Cartridge 30 includes a head 32 and a cylindrical body 34 which are coextensively joined together at a relatively narrow neck 36. A metallic end cap 38 covers a sealed diaphragm 40 which extends across cartridge 30 to prevent contamination and leakage of the fluid contents. A piston 42 is sized to be received in and slidable axially and reciprocally through the interior of cartridge 30.
Piston 42 is formed from a relatively dense resilient material, e.g., rubber, and can be moved distally through cartridge 30 for expulsing the fluid contents of the cartridge via the needle cannula 18. A screw-threaded rod 44 can be connected to the piston 42 so as to project outwardly from the end of piston 42.
Screw-threaded rod 44 can be mated to a screw-threaded piston stem of an associated holder to complete a piston assembly for controlling the movement of piston 42 through the interior of cartridge 30. It is contemplated that other means known in the art can be employed for attaching the rod to the piston stem.
The above-described medicament-containing cartridges are designed for use in conjunction with reusable or other disposable syringe holders. Exemplary useful syringe holders are described, for example, in Hadtke, U .S. Patent 4,585,445 and EPO 485,028.
Such a syringe holder 46 as depicted in Fig. 4, can comprise a cylindrical frame 48, a clamp 50, and a plunger element 52 containing a piston stem 58.
In preferred embodiments, the coupling system of this invention is practiced in conjunction with a pre-slit injection site as described in PCT/US89/00273, PCT/US90/01350 and depicted in Fig. 2. Injection site 62 has a cylindrical housing 64, a first end 66, a second end 68, and a hollow cylindrical fluid flow member 70 which can slidably engage a receiving member, e.g., the housing of a catheter, thereby providing a sterile fluid flow coupling. Internal male iuer threads 72, shown to be carried by housing 64 to adjacent the second end 68, engage a flange member knot :illustrated) when the injection site is rotated. The injection site 62 contains a res~alable septum 74 formed of, for example, a latex, synthetic rubber or thermoplastic elastomer. The septum 74 has either a partial or complete opening or slit 76.
The hub 20 preferably is attachable to the cartridge by snapping sleeve portion 22 over the distal end of the cartridge to engage the metal cap 38. In order to obtain the requisite sterile seal and flexibility, the hub preferably is fabricated of a plastic material such as po:Lyethylene or polypropylene, or a polypropylene copolymer containing a minor amount of, e.g., low density polyethylene, to increase the impact strength of the polymer. An example of the latter copolymer is Pro-fax 8523~~"', available from Hirr~ont Incorporated.
such copolymer is particularly preferred when the hub is prepared by conventional injection molding techniques.
The hub 20 can be optionally provided with a first set of fins 54 at the base of the blunt cannula for manufacturing purposes. Such fins may also provide a sense of resistance alerting the user, to prevent the cannula l6 and/or hub 20 from being penetrated too deeply into the port of an injection site as shown in Fig. 2. The hub can optionally be provided With a second set of fins 56 at the base of the sleeve to provide a stop for the blunt cannula sheath.
The coupling system.l0 of this invention can be prepared by inserting a needle cannula 18 through the insert 24. The insert 24 is preferably fabricated of an injection moldable plastic, e.g., polycarbonate or polypropylene, and can be pre-sterilized or pre-treated for improved adhesion, e.g., by corona discharge treatment. An adhesive, e.g., a UV
' curable epoxy resin, can be applied to the needle/insert interface and, subsequently, the resin can be cured. The coupling system 10 preferably is sterlizable such as by means of radiation, steam or ethylene oxide. The needle cannula-insert subassembly can then be press fit through the sleeve into the hub 20. The sheath 28 can then be fitted over the 211'~~60 WO 94/01170 - a - PCT/US93/061R~..
hub 20, and the coupling system-sheath subassembly can be snap fitted over the necked down end of the cartridge 30.
In use, the coupling system 10 of this invention operates in conjunction with conventional medicament-s containing cartridges, reusable syringe holders and injection sites during and after administration of an injection as follows. In the injection state, the prefilled medication cartridge 30 fitted with the coupling system 10 of this invention is loaded into cylindrical frame 48 of an assembled reusable syringe holder 46 such as described above so that blunt cannula 16 covered by sheath 28 extends distally outward from the frame. Cartridge 30 is then advanced by a health care worker distally through the holder by rotating clamping element 50 until the inwardly extending proximal end of needle cannula 12 penetrates sealed diaphragm 40 of cartridge 30.
Next, sheath 28 is removed to expose the outwardly extending distal end of blunt cannula 16. A screw threaded piston stem 58 is connected to piston 42 at the screw-threaded rod 44 thereof. The blunt cannula 16 is inserted into a pre-slit injection site, such as described above, and an axially and distally directed force is applied by the health care worker to piston stem 52, via actuation button 60. The distal force is transferred from piston stem 58 to piston 44 to drive the piston through medicament-containing cartridge 30 and thereby expulse the fluid contents of the cartridge 30 via needle cannula 18 through the fluid flow channel and into the fluid flow member 70 of the pre-slit injection site 62. After injection, the blunt cannula 16 is removed from the injection site. Subsequently, the plunger rod 44 is unscrewed from the piston thread and pulled proximally back, the clamp 50 is rotated to free the cartridge 30 and the cartridge unit is disposed of in an appropriate manner, the needle cannula 18 being safely covered by the hub 20, sleeve 22 and/or blunt cannula 16 during the entire procedure, thus reducing the possibility of accidental needle strikes.
The invention has been described in detail with particular reference to certain preferred embodiments thereof, '"7 94/01170 - 9 - PCT/US93/06199 but it will be understood that variations and modifications can be effected within the spirit and scope of the invention.
Claims (13)
1. A coupling apparatus for transferring fluids from a cartridge to an injection site, the apparatus comprising a syringe holder comprising a frame for holding a cartridge filled with medicament, clamping means for clamping the cartridge and a plunger element comprising a piston stem for expelling the contents of the cartridge into a needle cannula.
wherein the apparatus comprises a hub including a sleeve portion for engaging over a portion of a cartridge, the hub having a blunt cannula portion for piercing an injection site and forming a passageway extending from the sleeve portion through the blunt cannula portion, the needle cannula extending within the passageway of the hub and being fixed in the hub, the needle cannula having a proximal end, for fluid communication with a cartridge engaged by the sleeve portion, and a distal end disposed within the blunt cannula portion, so as to form a flow channel from the proximal end of the needle cannula to the distal end of the blunt cannula portion.
wherein the apparatus comprises a hub including a sleeve portion for engaging over a portion of a cartridge, the hub having a blunt cannula portion for piercing an injection site and forming a passageway extending from the sleeve portion through the blunt cannula portion, the needle cannula extending within the passageway of the hub and being fixed in the hub, the needle cannula having a proximal end, for fluid communication with a cartridge engaged by the sleeve portion, and a distal end disposed within the blunt cannula portion, so as to form a flow channel from the proximal end of the needle cannula to the distal end of the blunt cannula portion.
2. Apparatus according to Claim 1, wherein a clearance of at least 0.5mm is provided between the distal end of the needle cannula and the distal end of the blunt cannula portion.
3. Apparatus according to Claim 1, wherein the distal end of the needle cannula is flush with the distal end of the blunt cannula portion.
4. Apparatus according to Claim 1,2 or 3, wherein the proximal sleeve portion extends beyond the pointed proximal end of said needle cannula.
5. Apparatus according to Claim 4, wherein the axial distance between the proximal end of the sleeve portion and the pointed proximal end of the needle cannula is at least 2mm.
11
7. Apparatus according to any one of claims 1 to 6, including a removable sheath engaging the hub and surrounding the blunt cannula portion.
8. Apparatus according to any one of claims 1 to 7, wherein the hub is made of plastics material and the needle cannula is made of metal.
9. Apparatus according to any one of claims 1 to 8, including an insert, which fixedly connects the needle cannula to the hub, the insert receiving the needle cannula and being received in the passageway of the hub.
10. Apparatus according to Claim 9, wherein the insert is snap engaged in the passageway in the hub.
11. Apparatus according to any one of claims 1 to 10 in combination with a medicament containing cartridge, engaged in the proximal sleeve portion, with the proximal end of the needle cannula in fluid communication with the cartridge.
12. Apparatus according to Claim 11, wherein the cartridge is snap-engaged in the proximal sleeve portion.
13. Apparatus according to Claim 11 or 12, wherein the cartridge includes a diaphragm, wherein the clamping means is operable to cause the proximal end of the needle cannula to penetrate the diaphragm to provide fluid communication between the needle cannula and the cartridge.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US909,546 | 1992-07-06 | ||
| US07/909,546 US5389086A (en) | 1992-07-06 | 1992-07-06 | Safety cannula |
| PCT/US1993/006199 WO1994001170A1 (en) | 1992-07-06 | 1993-06-25 | Safety cannula |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2117060A1 CA2117060A1 (en) | 1994-01-20 |
| CA2117060C true CA2117060C (en) | 2003-04-01 |
Family
ID=25427424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002117060A Expired - Lifetime CA2117060C (en) | 1992-07-06 | 1993-06-25 | Safety cannula |
Country Status (18)
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| EP (1) | EP0607381B1 (en) |
| AR (1) | AR248354A1 (en) |
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| CA (1) | CA2117060C (en) |
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| RO (1) | RO111418B1 (en) |
| RU (1) | RU94017673A (en) |
| SG (1) | SG48703A1 (en) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ334983A (en) | 1991-12-18 | 2001-03-30 | Icu Medical Inc | Medical valve with a resilient seal |
| US5389086A (en) * | 1992-07-06 | 1995-02-14 | Sterling Winthrop Inc. | Safety cannula |
| JP3199524B2 (en) * | 1993-08-06 | 2001-08-20 | 日本メジフィジックス株式会社 | Luer needle unit and syringe |
| US6068011A (en) * | 1993-10-13 | 2000-05-30 | Paradis; Joseph R. | Control of fluid flow |
| US5746733A (en) * | 1994-05-19 | 1998-05-05 | Becton, Dickinson And Company | Syringe filling and delivery device |
| US5545146A (en) * | 1994-06-22 | 1996-08-13 | Ishak; Noshi A. | Catheter apparatus having a retractable intravenous needle assembly |
| US5501676A (en) * | 1995-01-13 | 1996-03-26 | Sanofi Winthrop, Inc. | Coupling system for safety cannula |
| US5653698A (en) * | 1995-01-13 | 1997-08-05 | Sanofi Winthrop, Inc. | Coupling systems for saftey cannula |
| WO1997000706A1 (en) * | 1995-06-20 | 1997-01-09 | Gould Vincent G | Dual function syringe and blunt assembly |
| US5616133A (en) * | 1995-10-23 | 1997-04-01 | Cardenas; Juan M. | Syringe for epidural catheter |
| US5738663A (en) * | 1995-12-15 | 1998-04-14 | Icu Medical, Inc. | Medical valve with fluid escape space |
| US5709619A (en) * | 1996-09-20 | 1998-01-20 | D'emidio; Robert C. | Batting practice device |
| US6162206A (en) | 1997-12-23 | 2000-12-19 | Baxter International Inc. | Resealable access site |
| US6364847B1 (en) | 1999-10-07 | 2002-04-02 | Sunscope International, Inc. | Blood sampling device |
| US6695817B1 (en) | 2000-07-11 | 2004-02-24 | Icu Medical, Inc. | Medical valve with positive flow characteristics |
| AU2001294956A1 (en) * | 2000-11-07 | 2002-05-21 | Biocrystal Ltd. | Access port septum and assembly |
| US20020143297A1 (en) * | 2001-03-30 | 2002-10-03 | Becton, Dickinson And Company | Adaptor for use with point-of-care testing cartridge |
| GB0129171D0 (en) * | 2001-12-06 | 2002-01-23 | Dca Design Int Ltd | Improvements in and relating to a medicament cartridge |
| US6908459B2 (en) | 2001-12-07 | 2005-06-21 | Becton, Dickinson And Company | Needleless luer access connector |
| TW200406829A (en) * | 2002-09-17 | 2004-05-01 | Adv Lcd Tech Dev Ct Co Ltd | Interconnect, interconnect forming method, thin film transistor, and display device |
| US20060161115A1 (en) | 2004-11-05 | 2006-07-20 | Fangrow Thomas F | Soft-grip medical connector |
| US7615035B2 (en) * | 2005-03-24 | 2009-11-10 | B. Braun Medical Inc. | Needleless access port valves |
| CA2652592C (en) * | 2006-05-16 | 2014-11-04 | Hospira, Inc. | Injection device and method of assembly and activation |
| DE602007014252D1 (en) | 2006-10-25 | 2011-06-09 | Icu Medical Inc | MEDICAL CONNECTOR |
| WO2008067467A2 (en) * | 2006-11-29 | 2008-06-05 | West Pharmaceutical Services, Inc. | Syringe cartridge system |
| US8002756B2 (en) * | 2006-12-08 | 2011-08-23 | Becton, Dickinson And Company | Method and apparatus for delivering a therapeutic substance through an injection port |
| US20080215014A1 (en) * | 2007-03-01 | 2008-09-04 | Greg Nordgren | Manually activated flow/no flow medical slit valves and related methods |
| US9149573B2 (en) * | 2007-03-16 | 2015-10-06 | Smiths Medical Asd, Inc. | Blunt cannula for accessing a slit septum |
| AU2009246225B2 (en) | 2008-05-14 | 2012-07-19 | J&J Solutions, Inc. | Systems and methods for safe medicament transport |
| US8454579B2 (en) | 2009-03-25 | 2013-06-04 | Icu Medical, Inc. | Medical connector with automatic valves and volume regulator |
| USD644731S1 (en) | 2010-03-23 | 2011-09-06 | Icu Medical, Inc. | Medical connector |
| US8758306B2 (en) | 2010-05-17 | 2014-06-24 | Icu Medical, Inc. | Medical connectors and methods of use |
| WO2011150037A1 (en) | 2010-05-27 | 2011-12-01 | J&J Solutions, Inc. | Closed fluid transfer system |
| US20120078214A1 (en) * | 2010-09-28 | 2012-03-29 | Tyco Healthcare Group Lp | Vial transfer needle assembly |
| US9751056B2 (en) | 2012-01-23 | 2017-09-05 | Merit Medical Systems, Inc. | Mixing syringe |
| US8834449B2 (en) | 2012-01-23 | 2014-09-16 | Ikomed Technologies, Inc. | Mixing syringe |
| EP2938375B1 (en) | 2012-12-31 | 2019-05-01 | Hospira, Inc. | Cartridge assembly for an injection system |
| NZ716552A (en) | 2013-08-02 | 2020-02-28 | J&J Solutions Inc D B A Corvida Medical | Compounding systems and methods for safe medicament transport |
| AU2014364218B2 (en) | 2013-12-11 | 2019-06-06 | Icu Medical, Inc. | Check valve |
| WO2016019328A1 (en) | 2014-07-31 | 2016-02-04 | Hospira, Inc. | Injection system |
| USD786427S1 (en) | 2014-12-03 | 2017-05-09 | Icu Medical, Inc. | Fluid manifold |
| USD793551S1 (en) | 2014-12-03 | 2017-08-01 | Icu Medical, Inc. | Fluid manifold |
| JP6895142B2 (en) | 2015-09-17 | 2021-06-30 | ジェイ アンド ジェイ ソリューションズ，インコーポレイテッド | Drug vial assembly |
| WO2017066406A1 (en) | 2015-10-13 | 2017-04-20 | J&J SOLUTIONS, INC. d/b/a Corvida Medical | Automated compounding equipment for closed fluid transfer system |
| JP6946749B2 (en) * | 2017-05-30 | 2021-10-06 | 株式会社ジェイ・エム・エス | Female connector |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA667624A (en) * | 1956-06-15 | 1963-07-30 | Braun Bernd | Containers for biological liquids |
| GB894653A (en) * | 1958-10-13 | 1962-04-26 | Cook Waite Lab Inc | Needle assembly |
| DK97091C (en) * | 1961-12-22 | 1963-10-14 | Novo Terapeutisk Labor As | Spray ampoule. |
| US3848593A (en) * | 1970-10-09 | 1974-11-19 | Affiliated Hospital Prod | Side loading disposable carpule syringe |
| US4329989A (en) * | 1981-02-23 | 1982-05-18 | Edsyn, Inc. | Liquid dispenser |
| US4624393A (en) * | 1981-07-02 | 1986-11-25 | Survival Technology, Inc. | Split hub assembly for a necked down cartridge tube |
| US4432759A (en) * | 1982-04-26 | 1984-02-21 | Abbott Laboratories | Connecting device for medical liquid containers |
| US4511359A (en) * | 1982-09-29 | 1985-04-16 | Manresa, Inc. | Sterile connection device |
| US4585445A (en) * | 1985-08-19 | 1986-04-29 | Sterling Drug Inc. | Hypodermic syringe holder for use with disposal ampoules |
| US4675020A (en) * | 1985-10-09 | 1987-06-23 | Kendall Mcgaw Laboratories, Inc. | Connector |
| US4643724A (en) * | 1985-12-16 | 1987-02-17 | Alcon Laboratories, Inc. | Syringe holder |
| US4834152A (en) * | 1986-02-27 | 1989-05-30 | Intelligent Medicine, Inc. | Storage receptacle sealing and transfer apparatus |
| US4850970A (en) * | 1987-03-26 | 1989-07-25 | American Home Products, Corp. | Two part mastitis cannula cap |
| US4887363A (en) * | 1987-07-08 | 1989-12-19 | Nordson Corporation | Fluidized bed hopper |
| CA1335167C (en) * | 1988-01-25 | 1995-04-11 | Steven C. Jepson | Pre-slit injection site and associated cannula |
| US5135489A (en) * | 1988-01-25 | 1992-08-04 | Baxter International Inc. | Pre-slit injection site and tapered cannula |
| US5066287A (en) * | 1988-07-27 | 1991-11-19 | Ryan Medical, Inc. | Safety multiple sample rear adapter assembly |
| GB2223407A (en) * | 1988-08-12 | 1990-04-11 | Patricia Moore | Improvements in endotracheal tubes |
| WO1990006071A1 (en) * | 1988-11-29 | 1990-06-14 | Mueller Siegfried | Process for applying a perm or water-wave to previously permed or water-waved hair and a roller for implementing the process |
| US5071413A (en) * | 1990-06-13 | 1991-12-10 | Utterberg David S | Universal connector |
| DE4025717A1 (en) * | 1990-08-14 | 1992-02-20 | Hoechst Ag | SYRINGE RACK |
| US5350367A (en) * | 1990-11-06 | 1994-09-27 | Sterling Winthrop Inc. | Snap together hypodermic syringe holder |
| US5389086A (en) * | 1992-07-06 | 1995-02-14 | Sterling Winthrop Inc. | Safety cannula |
| US5226900A (en) * | 1992-08-03 | 1993-07-13 | Baxter International Inc. | Cannula for use in drug delivery systems and systems including same |
-
1992
- 1992-07-06 US US07/909,546 patent/US5389086A/en not_active Expired - Lifetime
-
1993
- 1993-06-25 BR BR9305575A patent/BR9305575A/en not_active Application Discontinuation
- 1993-06-25 ES ES93915492T patent/ES2118969T3/en not_active Expired - Lifetime
- 1993-06-25 NZ NZ253964A patent/NZ253964A/en unknown
- 1993-06-25 PL PL93302683A patent/PL302683A1/en unknown
- 1993-06-25 CA CA002117060A patent/CA2117060C/en not_active Expired - Lifetime
- 1993-06-25 DE DE69318816T patent/DE69318816T2/en not_active Expired - Lifetime
- 1993-06-25 EP EP93915492A patent/EP0607381B1/en not_active Expired - Lifetime
- 1993-06-25 RO RO94-00340A patent/RO111418B1/en unknown
- 1993-06-25 SG SG1995002050A patent/SG48703A1/en unknown
- 1993-06-25 AU AU45455/93A patent/AU666393B2/en not_active Ceased
- 1993-06-25 RU RU94017673/14A patent/RU94017673A/en unknown
- 1993-06-25 AT AT93915492T patent/ATE166584T1/en not_active IP Right Cessation
- 1993-07-05 MX MX9304042A patent/MX9304042A/en not_active IP Right Cessation
- 1993-07-06 IL IL10625093A patent/IL106250A/en not_active IP Right Cessation
- 1993-07-13 AR AR93325143A patent/AR248354A1/en active
-
1994
- 1994-03-04 NO NO940770A patent/NO302931B1/en unknown
- 1994-03-04 FI FI941047A patent/FI941047A/en unknown
- 1994-03-04 NO NO940770A patent/NO940770D0/en unknown
-
1995
- 1995-01-23 US US08/376,727 patent/US5531711A/en not_active Expired - Fee Related
-
1996
- 1996-04-24 US US08/639,301 patent/US5785692A/en not_active Expired - Lifetime
Also Published As
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| RU94017673A (en) | 1996-08-10 |
| NO302931B1 (en) | 1998-05-11 |
| SG48703A1 (en) | 1998-05-18 |
| NO940770D0 (en) | 1994-03-04 |
| BR9305575A (en) | 1996-01-02 |
| AR248354A1 (en) | 1995-08-18 |
| PL302683A1 (en) | 1994-08-22 |
| RO111418B1 (en) | 1996-10-31 |
| IL106250A0 (en) | 1993-11-15 |
| MX9304042A (en) | 1994-04-29 |
| ATE166584T1 (en) | 1998-06-15 |
| US5389086A (en) | 1995-02-14 |
| NO940770L (en) | 1994-05-03 |
| ES2118969T3 (en) | 1998-10-01 |
| CA2117060A1 (en) | 1994-01-20 |
| IL106250A (en) | 1998-08-16 |
| FI941047A0 (en) | 1994-03-04 |
| EP0607381B1 (en) | 1998-05-27 |
| AU4545593A (en) | 1994-01-31 |
| AU666393B2 (en) | 1996-02-08 |
| FI941047A (en) | 1994-04-08 |
| DE69318816D1 (en) | 1998-07-02 |
| NZ253964A (en) | 1996-07-26 |
| US5785692A (en) | 1998-07-28 |
| US5531711A (en) | 1996-07-02 |
| EP0607381A1 (en) | 1994-07-27 |
| DE69318816T2 (en) | 1999-02-04 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
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| MKEC | Expiry (correction) |
Effective date: 20131009 |