CA2117351A1 - Preparation of Tablets of Increased Strength - Google Patents

Preparation of Tablets of Increased Strength

Info

Publication number
CA2117351A1
CA2117351A1 CA 2117351 CA2117351A CA2117351A1 CA 2117351 A1 CA2117351 A1 CA 2117351A1 CA 2117351 CA2117351 CA 2117351 CA 2117351 A CA2117351 A CA 2117351A CA 2117351 A1 CA2117351 A1 CA 2117351A1
Authority
CA
Canada
Prior art keywords
tablets
increased strength
preparation
binder
tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA 2117351
Other languages
French (fr)
Other versions
CA2117351C (en
Inventor
Julian Belknap Lo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Julian Belknap Lo
Pfizer Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Julian Belknap Lo, Pfizer Limited filed Critical Julian Belknap Lo
Publication of CA2117351A1 publication Critical patent/CA2117351A1/en
Application granted granted Critical
Publication of CA2117351C publication Critical patent/CA2117351C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates

Abstract

Tablets of increased strength are manufactured by combining and compressing a meltable binder, excipients and a pharmaceutically active agent into a tablet, melting the binder in the tablet, and then solidifying the binder.
CA002117351A 1992-01-13 1992-09-10 Preparation of tablets of increased strength Expired - Fee Related CA2117351C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81955392A 1992-01-13 1992-01-13
US07/819,553 1992-01-13

Publications (2)

Publication Number Publication Date
CA2117351A1 true CA2117351A1 (en) 1993-07-22
CA2117351C CA2117351C (en) 1998-03-03

Family

ID=25228458

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002117351A Expired - Fee Related CA2117351C (en) 1992-01-13 1992-09-10 Preparation of tablets of increased strength

Country Status (12)

Country Link
US (1) US5853758A (en)
EP (1) EP0620728B1 (en)
JP (1) JP2640570B2 (en)
AT (1) ATE147261T1 (en)
CA (1) CA2117351C (en)
DE (1) DE69216642T2 (en)
DK (1) DK0620728T3 (en)
ES (1) ES2096103T3 (en)
FI (1) FI109086B (en)
GR (1) GR3022458T3 (en)
PT (1) PT101175B (en)
WO (1) WO1993013758A1 (en)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW438798B (en) * 1992-10-07 2001-06-07 Pfizer 3-substituted 2-oxindole-1-carboxamide pharmaceutical compositions
ES2076106B1 (en) * 1993-08-26 1996-06-16 Pfizer PHARMACEUTICAL COMPOSITIONS BASED ON 2-OXINDOL-1-CARBOXAMIDES 3-SUBSTITUTED
EP0754465A4 (en) * 1994-04-01 1998-05-06 Tsumura & Co Process for producing sustained-release tablets and enteric tablets
PT831790E (en) * 1995-06-07 2003-07-31 Elan Drug Delivery Ltd METHODS FOR THE INCORPORATION OF STABLE MODE OF SUBSTANCES INSIDE EXPANDED DRY MATRIXES AND COMPOSITIONS THROUGH THEM OBTAINED
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US6413541B1 (en) 1999-01-13 2002-07-02 Dainippon Pharmaceutical Co., Ltd. Disintegrating tablet in oral cavity and production thereof
JP4504467B2 (en) * 1998-07-30 2010-07-14 佐藤製薬株式会社 Orally disintegrating tablets
US20030026835A1 (en) * 1999-02-15 2003-02-06 Sumitomo Pharmaceuticals Company Limited Tablets disintegrating rapidly in the oral cavity
GB9908014D0 (en) 1999-04-08 1999-06-02 Scherer Corp R P Pharmaceutical compositions
GB2350582A (en) * 1999-06-01 2000-12-06 Hiran Asoka Malinga Ratwatte A method of tableting
US6258381B1 (en) * 2000-02-11 2001-07-10 Mcneil-Ppc, Inc. Tablet and process for making the same
US6277409B1 (en) 2000-02-11 2001-08-21 Mcneil-Ppc, Inc. Protective coating for tablet
US20020015730A1 (en) * 2000-03-09 2002-02-07 Torsten Hoffmann Pharmaceutical formulations and method for making
US20020001617A1 (en) * 2000-05-26 2002-01-03 Chang-Hyun Lee Rapidly disintegrating tablet and process for the manufacture thereof
US20100015246A1 (en) * 2000-06-27 2010-01-21 Shire International Licensing B.V. Combination of a lanthanum compound and bone enhancing agent for the treatment of bone diseases
US6733781B2 (en) 2000-12-06 2004-05-11 Wyeth Fast dissolving tablet
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet
CA2350195C (en) * 2000-12-20 2003-06-10 Duchesnay Inc. Rapid onset formulation of pyridoxine hydrochloride and doxylamine succinate
US6544552B2 (en) 2001-01-11 2003-04-08 Particle And Coating Technologies, Inc. Method of producing porous tablets with improved dissolution properties
EP1226818A1 (en) * 2001-01-26 2002-07-31 Pfizer Products Inc. Pharmaceutical dosage forms with enhanced cohesive and compressibility properties
EP1389102B1 (en) * 2001-04-23 2011-03-02 Shire International Licensing B.V. Use of lanthanum carbonate for the prevention of kidney stone disease
US6872405B2 (en) 2001-05-10 2005-03-29 Yamanouchi Pharmaceutical Co., Ltd. Quick-disintegrating tablet in buccal cavity and manufacturing method thereof
WO2002092057A1 (en) * 2001-05-10 2002-11-21 Yamanouchi Pharmaceutical Co., Ltd. Tablets quickly disintegrating in the oral cavity and process for producing the same
US6509040B1 (en) 2001-06-22 2003-01-21 R.P. Scherer Corporation Fast dispersing dosage forms essentially free of mammalian gelatin
US7914811B2 (en) 2001-06-29 2011-03-29 Mcneil-Ppc, Inc. Brittle-coating, soft core dosage form
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
EP1485296B1 (en) * 2002-02-13 2011-07-20 Michael K. Weibel Drug dose - form and method of manufacture
GB0204772D0 (en) * 2002-02-28 2002-04-17 Phoqus Ltd Pharmaceutical dosage forms
US20040109889A1 (en) 2002-12-04 2004-06-10 Bunick Frank J. Surface treatment composition for soft substrates
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
US20040131672A1 (en) * 2003-01-07 2004-07-08 Nilobon Podhipleux Direct compression pharmaceutical composition containing a pharmaceutically active ingredient with poor flowing properties
US7381428B2 (en) * 2003-08-26 2008-06-03 Shire International Licensing B.V. Stabilized lanthanum carbonate compositions
EA200970709A1 (en) * 2003-08-26 2010-04-30 Шир Холдингз Аг PHARMACEUTICAL COMPOSITION CONTAINING LANTHANE COMPOUNDS
US8591974B2 (en) * 2003-11-21 2013-11-26 Kraft Foods Global Brands Llc Delivery system for two or more active components as part of an edible composition
US20050112236A1 (en) 2003-11-21 2005-05-26 Navroz Boghani Delivery system for active components as part of an edible composition having preselected tensile strength
US8591973B2 (en) 2005-05-23 2013-11-26 Kraft Foods Global Brands Llc Delivery system for active components and a material having preselected hydrophobicity as part of an edible composition
US8389032B2 (en) 2005-05-23 2013-03-05 Kraft Foods Global Brands Llc Delivery system for active components as part of an edible composition having selected particle size
US8597703B2 (en) 2005-05-23 2013-12-03 Kraft Foods Global Brands Llc Delivery system for active components as part of an edible composition including a ratio of encapsulating material and active component
US8591968B2 (en) 2005-05-23 2013-11-26 Kraft Foods Global Brands Llc Edible composition including a delivery system for active components
US8591972B2 (en) 2005-05-23 2013-11-26 Kraft Foods Global Brands Llc Delivery system for coated active components as part of an edible composition
CN101018555A (en) * 2004-07-27 2007-08-15 夏尔制药公司 Method of treating hyperphosphataemia using lanthanum hydroxycarbonate
US7700608B2 (en) * 2004-08-04 2010-04-20 Shire Holdings Ag Quinazoline derivatives and their use in the treatment of thrombocythemia
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
US20070104799A1 (en) * 2005-11-09 2007-05-10 Shire International Licensing B.V. Treatment of chronic kidney disease (CKD) subjects using lanthanum compounds
US20070207206A1 (en) * 2006-03-02 2007-09-06 Rice Bronwyn C Chewable pain formula
US20070259052A1 (en) * 2006-05-05 2007-11-08 Shire International Licensing B.V. Assay for lanthanum hydroxycarbonate
SA07280459B1 (en) 2006-08-25 2011-07-20 بيورديو فارما إل. بي. Tamper Resistant Oral Pharmaceutical Dosage Forms Comprising an Opioid Analgesic
US20090068262A1 (en) * 2007-04-04 2009-03-12 Ilan Zalit Rapid dissolution of combination products
US20090110716A1 (en) 2007-10-31 2009-04-30 Frank Bunick Orally disintegrative dosage form
US8784781B2 (en) 2009-09-24 2014-07-22 Mcneil-Ppc, Inc. Manufacture of chewing gum product with radiofrequency
US8858210B2 (en) 2009-09-24 2014-10-14 Mcneil-Ppc, Inc. Manufacture of variable density dosage forms utilizing radiofrequency energy
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
JP5309262B2 (en) 2009-12-02 2013-10-09 アプタリス ファーマ リミテッド Fexofenadine microcapsule and composition containing the same
ES2656944T3 (en) 2011-04-29 2018-03-01 Intercontinental Great Brands Llc Encapsulated acid, method of preparation thereof, and chewing gum comprising it
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet
CN103432091A (en) * 2013-09-13 2013-12-11 钟术光 Improved-performance tablet and preparation method thereof
ES2750323T3 (en) 2014-01-10 2020-03-25 Johnson & Johnson Consumer Inc Method for manufacturing a tablet using radio frequency and loss coated particles
CN105769887B (en) * 2014-12-23 2019-04-30 上海复星星泰医药科技有限公司 A kind of compound fructose diphosphate sodium fructose oral disintegrating tablet and preparation method thereof
US20190022013A1 (en) 2015-12-19 2019-01-24 First Time Us Generics Llc Soft-chew tablet pharmaceutical formulations
CN108712900A (en) 2015-12-19 2018-10-26 第时间美国泛型药物有限公司 Soft chewable tablet pharmaceutical preparation
US11400047B2 (en) * 2017-02-01 2022-08-02 Johnson & Johnson Consumer Inc. Lozenge comprising micronized benzocaine and polyethylene glycol
US10493026B2 (en) 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles
JP7145121B2 (en) 2019-05-31 2022-09-30 信越化学工業株式会社 Tablet manufacturing method

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2987445A (en) * 1958-10-10 1961-06-06 Rohm & Haas Drug composition
BE636865A (en) * 1962-08-31
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
DE1617593A1 (en) * 1965-10-12 1971-04-29 Leo Pharm Prod Ltd Method of making tablets or pills
US3487138A (en) * 1966-11-23 1969-12-30 Merck & Co Inc Process for preparing a delayed release medicinal tablet
US3653914A (en) * 1970-03-20 1972-04-04 Alberto Culver Co Production of tablets
ZA723701B (en) * 1971-06-04 1973-04-25 Boehringer Mannheim Gmbh Process for the granulation of powdered tablet masses
DE2246013A1 (en) * 1972-09-20 1974-03-28 Boehringer Mannheim Gmbh PROCESS FOR THE MANUFACTURING OF POROUS TABLETS
JPS5031022A (en) * 1973-05-29 1975-03-27
US3961004A (en) * 1974-04-11 1976-06-01 Auburn Research Foundation Method of tabletting using gluconolactone as the direct compression diluent
US3923939A (en) * 1974-06-07 1975-12-02 Alza Corp Process for improving release kinetics of a monolithic drug delivery device
JPS58403B2 (en) * 1975-07-24 1983-01-06 武田薬品工業株式会社 L- Ascorbine Sanseizaino Seizouhou
DE2556561C2 (en) * 1975-12-16 1983-04-14 Boehringer Mannheim Gmbh, 6800 Mannheim Process for the production of porous tablets
CA1097233A (en) * 1977-07-20 1981-03-10 George K. E. Gregory Packages
US4166107A (en) * 1978-07-25 1979-08-28 The United States Of America As Represented By The Secretary Of Agriculture Sustained release bolus formulations containing insect growth regulators for control of livestock pests
US4994227A (en) * 1986-03-10 1991-02-19 American Cyanamid Company Method for the preparation of sustained released bolus formulation
US4760094A (en) * 1986-10-21 1988-07-26 American Home Products Corporation (Del.) Spray dried acetaminophen
US5137669A (en) * 1988-03-02 1992-08-11 Endocon, Inc. Manufacture of partially fused peptide pellet
DE3812567A1 (en) * 1988-04-15 1989-10-26 Basf Ag METHOD FOR PRODUCING PHARMACEUTICAL MIXTURES
LU87233A1 (en) * 1988-06-07 1990-02-28 Pharlyse Sa PHARMACEUTICAL COMPOSITION BASED ON A NON-STEROIDAL ANTI-INFLAMMATORY, PREPARATION METHOD AND USE THEREOF
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
AU657514B2 (en) * 1991-01-03 1995-03-16 Glaxo Canada Inc. Method for production of solid pharmaceutical preparation

Also Published As

Publication number Publication date
PT101175B (en) 1999-09-30
US5853758A (en) 1998-12-29
DK0620728T3 (en) 1997-07-07
FI109086B (en) 2002-05-31
GR3022458T3 (en) 1997-04-30
JP2640570B2 (en) 1997-08-13
PT101175A (en) 1994-03-31
CA2117351C (en) 1998-03-03
WO1993013758A1 (en) 1993-07-22
ATE147261T1 (en) 1997-01-15
FI943327A0 (en) 1994-07-12
DE69216642T2 (en) 1997-05-07
JPH07503237A (en) 1995-04-06
EP0620728B1 (en) 1997-01-08
ES2096103T3 (en) 1997-03-01
EP0620728A1 (en) 1994-10-26
FI943327A (en) 1994-07-12
DE69216642D1 (en) 1997-02-20

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Legal Events

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EEER Examination request
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