CA2120303A1 - Cyclic adhesion inhibitors - Google Patents

Cyclic adhesion inhibitors

Info

Publication number
CA2120303A1
CA2120303A1 CA002120303A CA2120303A CA2120303A1 CA 2120303 A1 CA2120303 A1 CA 2120303A1 CA 002120303 A CA002120303 A CA 002120303A CA 2120303 A CA2120303 A CA 2120303A CA 2120303 A1 CA2120303 A1 CA 2120303A1
Authority
CA
Canada
Prior art keywords
adhesion inhibitors
cyclic adhesion
cyclic
inhibitors
cyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002120303A
Other languages
French (fr)
Other versions
CA2120303C (en
Inventor
Alfred Jonczyk
Gunter Holzemann
Brunhilde Felding-Habermann
Friedrich Rippmann
Beate Diefenbach
Horst Kessler
Roland Haubner
Jochen Wermuth
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6484433&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2120303(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CA2120303A1 publication Critical patent/CA2120303A1/en
Application granted granted Critical
Publication of CA2120303C publication Critical patent/CA2120303C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to novel cyclopeptides of the formula I cyclo-(Arg-B-Asp-D-E) I in which B, D and E have the meaning given in Claim 1, and their salts. These compounds act as integrin inhibitors and can be used in particular for the prophylaxis and treatment of disorders of the circulation and in tumour therapy.
CA002120303A 1993-04-01 1994-03-30 Cyclic adhesion inhibitors Expired - Lifetime CA2120303C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4310643A DE4310643A1 (en) 1993-04-01 1993-04-01 Cyclic adhesion inhibitors
DEP4310643.9 1993-04-01

Publications (2)

Publication Number Publication Date
CA2120303A1 true CA2120303A1 (en) 1994-10-02
CA2120303C CA2120303C (en) 2007-05-01

Family

ID=6484433

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002120303A Expired - Lifetime CA2120303C (en) 1993-04-01 1994-03-30 Cyclic adhesion inhibitors

Country Status (20)

Country Link
US (2) US5849692A (en)
EP (1) EP0632053B1 (en)
JP (1) JP3694332B2 (en)
KR (1) KR100304201B1 (en)
CN (1) CN1056851C (en)
AT (1) ATE184288T1 (en)
AU (1) AU684489B2 (en)
CA (1) CA2120303C (en)
CZ (1) CZ286768B6 (en)
DE (2) DE4310643A1 (en)
DK (1) DK0632053T3 (en)
ES (1) ES2138632T3 (en)
GR (1) GR3032074T3 (en)
HU (1) HUT69726A (en)
NO (1) NO313756B1 (en)
PL (1) PL178791B1 (en)
RU (1) RU2130030C1 (en)
SK (1) SK281828B6 (en)
TW (1) TW343198B (en)
UA (1) UA34436C2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693612A (en) * 1994-04-30 1997-12-02 Merck Patent Gesellschaft Mit Beschrankter Haftung Cyclopeptides of the formula I
US6689787B1 (en) 1998-12-23 2004-02-10 G. D. Searle & Co. Method of using an integrin antagonist and radiation therapy as combination therapy in the treatment of neoplasia

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5753230A (en) 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US6500924B1 (en) 1996-05-31 2002-12-31 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis
US7053041B1 (en) 1996-05-31 2006-05-30 The Scripps Research Institute Methods and compositions useful for inhibition of αvβ5mediated angiogenesis
DE19534016A1 (en) * 1995-09-14 1997-03-20 Merck Patent Gmbh Biotin derivatives
DE19534177A1 (en) * 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclic adhesion inhibitors
DE19538741A1 (en) * 1995-10-18 1997-04-24 Merck Patent Gmbh Cyclopeptide derivatives
DE19613933A1 (en) * 1996-04-06 1997-10-09 Merck Patent Gmbh Cyclic adhesion inhibitors
DE19736772A1 (en) * 1997-08-23 1999-02-25 Merck Patent Gmbh New guanidino-substituted bi:cyclic peptide compounds
UA71608C2 (en) 1999-03-11 2004-12-15 Merck Patent Gmbh A method for producing the cyclic pentapeptide
DE19933173A1 (en) 1999-07-15 2001-01-18 Merck Patent Gmbh Cyclic peptide derivatives as inhibitors of the integrin alpha¶v¶beta¶6¶
US6359015B1 (en) 2000-02-28 2002-03-19 The United States Of America As Represented By The Department Of Veterans Affairs Method for antagonizing inhibition effects of alcohol on cell adhesion
US6624187B1 (en) * 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
DE10040105A1 (en) 2000-08-17 2002-02-28 Merck Patent Gmbh Peptide and peptide mimetic derivatives with integrin inhibitor properties
FR2814744B1 (en) * 2000-10-04 2002-11-29 Commissariat Energie Atomique CYCLOPEPTIDES, THEIR PREPARATION PROCESS AND THEIR USE AS ANGIOGENESIS INHIBITOR OR ACTIVATOR
MXPA03007878A (en) * 2001-03-02 2004-07-08 Medimmune Inc Methods of preventing or treating inflammatory or autoimmune disorders by administering integrin alphav beta3 antagonists.
US7879267B2 (en) * 2001-08-02 2011-02-01 J&J Vision Care, Inc. Method for coating articles by mold transfer
JP2005525368A (en) * 2002-03-04 2005-08-25 メディミューン，インコーポレーテッド Method for preventing or treating disorders in which an integrin αvβ3 antagonist is administered in combination with an HMG-CoA reductase inhibitor or bisphosphonate
EP1487492A4 (en) * 2002-03-04 2008-10-01 Medimmune Inc The prevention or treatment of cancer using integrin alphavbeta3 antagonists in combination with other agents
JP2005535572A (en) * 2002-04-12 2005-11-24 メディミューン，インコーポレーテッド Recombinant anti-interleukin-9 antibody
GB0217017D0 (en) * 2002-07-23 2002-08-28 Bioacta Ltd Peptide 2
ITRM20020402A1 (en) * 2002-07-29 2004-01-29 Sigma Tau Ind Farmaceuti FLUORO-ALCHIL-CYCLOPEPTIDES DERIVATIVES WITH ANTI-INTEGRINE ACTIVITIES.
US6977272B2 (en) * 2002-10-16 2005-12-20 President And Fellows Of Harvard College Method for antagonizing inhibition effects of alcohol on cell adhesion
CA2514653A1 (en) * 2003-01-30 2004-08-12 Medimmune, Inc. Uses of integrin alphavbeta3 antagonists
CA2521826C (en) * 2003-04-11 2013-08-06 Jennifer L. Reed Recombinant il-9 antibodies and uses thereof
US7351739B2 (en) * 2004-04-30 2008-04-01 Wellgen, Inc. Bioactive compounds and methods of uses thereof
ITRM20040239A1 (en) * 2004-05-13 2004-08-13 Sigma Tau Ind Farmaceuti CYCLOPEPTIDIC DERIVATIVES FOR ANTI-INTEGRINE ACTIVITIES.
JP2008518023A (en) 2004-10-27 2008-05-29 メディミューン，インコーポレーテッド Regulation of antibody specificity by altering affinity for cognate antigens
EP2851064A3 (en) 2006-07-11 2015-08-05 Roy C. Levitt Rhinosinusitis prevention and therapy with proinflammatory cytokine inhibitors
WO2008021237A1 (en) 2006-08-10 2008-02-21 Arubor Corporation Localized therapy of lower airways inflammatory disorders with proinflammatory cytokine inhibitors
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
NZ577107A (en) 2006-11-10 2012-01-12 Cara Therapeutics Inc Synthetic peptide amide ligands of the kappa opiod receptor
US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
WO2009124754A1 (en) 2008-04-08 2009-10-15 Merck Patent Gmbh Compositions containing cyclic peptides and methods of use
PT2358737T (en) 2008-10-23 2017-06-12 Steba Biotech S A Rgd-containing peptidomimetics and uses thereof
CN101906141B (en) * 2009-06-02 2013-04-17 首都医科大学 Conjugates of one class of peptide chain and double fatty alcohol chains as well as preparation method and application thereof
CN101906144B (en) * 2009-06-03 2013-06-19 首都医科大学 Conjugate formed by conjugating one Arg-Gly-Asp-Val chain and two fatty alcohol chains by Asp, synthesis thereof and medical application thereof
RU2655763C2 (en) * 2016-10-24 2018-05-29 Общество С Ограниченной Ответственностью "Айвикс" Pharmaceutical composition and method for treating female sexual dysfunctions
RU2626002C1 (en) 2016-10-24 2017-07-21 Общество С Ограниченной Ответственностью "Айвикс" New group of peptides for treatment of female sexual dysfunction
US10494403B2 (en) 2018-03-06 2019-12-03 Ciphore Biomed Technology Limited Company Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472305A (en) * 1983-05-17 1984-09-18 Sterling Drug Inc. Hexapeptide amides
JP2945680B2 (en) * 1988-09-09 1999-09-06 旭硝子株式会社 Peptide derivatives and their uses
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
JPH04264097A (en) * 1991-02-16 1992-09-18 Asahi Glass Co Ltd Peptide derivative and it's use
HUT63609A (en) * 1992-03-10 1993-09-28 Sandoz Ag Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
UA43823C2 (en) * 1992-07-06 2002-01-15 Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг PHARMACEUTICAL COMPOSITION FOR INTEGRIN INHIBITION <font face = "Symbol"> a </font> <sub> V </sub> <font face = "Symbol"> b </font> <sub> 3 </sub> cell adhesion mammal WAY treatment and prevention of diseases associated with cell adhesion DISORDERS, METHOD FOR BINDING LOCK integrin fibrinogen, a composition for wound healing
US5753230A (en) * 1994-03-18 1998-05-19 The Scripps Research Institute Methods and compositions useful for inhibition of angiogenesis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5693612A (en) * 1994-04-30 1997-12-02 Merck Patent Gesellschaft Mit Beschrankter Haftung Cyclopeptides of the formula I
US6689787B1 (en) 1998-12-23 2004-02-10 G. D. Searle & Co. Method of using an integrin antagonist and radiation therapy as combination therapy in the treatment of neoplasia

Also Published As

Publication number Publication date
NO941152D0 (en) 1994-03-29
SK38394A3 (en) 1995-02-08
HU9400937D0 (en) 1994-06-28
SK281828B6 (en) 2001-08-06
UA34436C2 (en) 2001-03-15
CZ70494A3 (en) 1995-01-18
AU5918594A (en) 1994-10-06
EP0632053A3 (en) 1995-02-15
US5849692A (en) 1998-12-15
KR100304201B1 (en) 2001-11-30
EP0632053A2 (en) 1995-01-04
JP3694332B2 (en) 2005-09-14
HUT69726A (en) 1995-09-28
ES2138632T3 (en) 2000-01-16
DE4310643A1 (en) 1994-10-06
JPH06329698A (en) 1994-11-29
RU2130030C1 (en) 1999-05-10
CZ286768B6 (en) 2000-07-12
DE59408715D1 (en) 1999-10-14
CN1099760A (en) 1995-03-08
NO941152L (en) 1994-10-03
US6169072B1 (en) 2001-01-02
GR3032074T3 (en) 2000-03-31
CN1056851C (en) 2000-09-27
PL178791B1 (en) 2000-06-30
ATE184288T1 (en) 1999-09-15
CA2120303C (en) 2007-05-01
NO313756B1 (en) 2002-11-25
TW343198B (en) 1998-10-21
DK0632053T3 (en) 2000-03-13
EP0632053B1 (en) 1999-09-08
AU684489B2 (en) 1997-12-18

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Effective date: 20140331