CA2123048A1 - Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments - Google Patents
Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicamentsInfo
- Publication number
- CA2123048A1 CA2123048A1 CA002123048A CA2123048A CA2123048A1 CA 2123048 A1 CA2123048 A1 CA 2123048A1 CA 002123048 A CA002123048 A CA 002123048A CA 2123048 A CA2123048 A CA 2123048A CA 2123048 A1 CA2123048 A1 CA 2123048A1
- Authority
- CA
- Canada
- Prior art keywords
- medicaments
- compounds
- processes
- preparation
- bile acids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Abstract
Tetrazole-bile acid derivatives of the formula I
in which G1, G2 and X have the meanings given and processes for their preparation are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.
in which G1, G2 and X have the meanings given and processes for their preparation are described. The compounds have useful pharmacological properties and can therefore be used as medicaments.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4315368 | 1993-05-08 | ||
DEP4315368.2 | 1993-05-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2123048A1 true CA2123048A1 (en) | 1994-11-09 |
CA2123048C CA2123048C (en) | 2005-11-29 |
Family
ID=6487579
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002123048A Expired - Fee Related CA2123048C (en) | 1993-05-08 | 1994-05-06 | Tetrazole derivatives of bile acids, processes for their preparation and the use of these compounds as medicaments |
Country Status (19)
Country | Link |
---|---|
US (1) | US5466815A (en) |
EP (1) | EP0624596B1 (en) |
JP (1) | JP3476157B2 (en) |
KR (1) | KR100333149B1 (en) |
AT (1) | ATE163938T1 (en) |
AU (1) | AU666440B2 (en) |
CA (1) | CA2123048C (en) |
CY (1) | CY2119B1 (en) |
CZ (1) | CZ289515B6 (en) |
DE (1) | DE59405410D1 (en) |
DK (1) | DK0624596T3 (en) |
ES (1) | ES2115096T3 (en) |
FI (1) | FI942075A (en) |
GR (1) | GR3026496T3 (en) |
HU (1) | HU217439B (en) |
IL (1) | IL109581A (en) |
NO (1) | NO304795B1 (en) |
NZ (1) | NZ260469A (en) |
TW (1) | TW289757B (en) |
Families Citing this family (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0624593A3 (en) * | 1993-05-08 | 1995-06-07 | Hoechst Ag | Bile acid derivates, a method for their production and their use as medicines. |
TW289020B (en) * | 1993-05-08 | 1996-10-21 | Hoechst Sktiengesellschaft | |
US6323190B1 (en) * | 1998-07-31 | 2001-11-27 | The Univeristy Of Georgia Research Foundation, Inc. | Estrogen mimetics lacking reproductive tract effects |
WO2000066611A1 (en) | 1999-04-30 | 2000-11-09 | Arch Development Corporation | Steroid derivatives |
US7086134B2 (en) * | 2000-08-07 | 2006-08-08 | Shipley Company, L.L.C. | Alignment apparatus and method for aligning stacked devices |
WO2002062302A2 (en) * | 2001-02-08 | 2002-08-15 | The University Of Chicago | Steroidal derivatives |
US7078396B2 (en) * | 2001-05-03 | 2006-07-18 | Arch Development Corporation | Method of treating disorder related to high cholesterol concentration |
CA2446314C (en) * | 2001-05-03 | 2011-02-22 | The University Of Chicago | Liver x receptor agonists |
US20070197484A1 (en) * | 2001-05-03 | 2007-08-23 | Ching Song | Method of treating disorder related to high cholesterol concentration |
US6816317B2 (en) * | 2002-01-31 | 2004-11-09 | Lightel Technologies Inc. | Collimator for ready fitting to an optical device with precise optical alignment without need for adjusting positions or angles to compensate for offsets or deviations during optical device assembly and method of making same |
EP1494533A2 (en) * | 2002-04-12 | 2005-01-12 | The University of Chicago | Farnesoid x-activated receptor agonists |
JP2008507477A (en) | 2004-07-08 | 2008-03-13 | ノボ ノルディスク アクティーゼルスカブ | Polypeptide extension tag |
US20070032464A1 (en) * | 2004-10-08 | 2007-02-08 | Shutsung Liao | Methods of treating cancers |
US7960439B1 (en) | 2006-06-12 | 2011-06-14 | Iowa State University Research Foundation, Inc. | Environmentally sensitive foldable oligomers |
CA2769203A1 (en) * | 2009-07-29 | 2011-02-03 | University Of Chicago | Liver x receptor agonists |
DK3400944T3 (en) | 2010-11-08 | 2020-10-12 | Albireo Ab | IBAT INHIBITORS FOR THE TREATMENT OF LIVER DISEASES |
CN103228270B (en) | 2010-11-08 | 2016-02-10 | 阿尔比里奥公司 | Containing the drug regimen of ibat inhibitor and bile acid binding agent |
JO3301B1 (en) | 2013-04-26 | 2018-09-16 | Albireo Ab | Crystal modifications of elobixibat |
KR102560954B1 (en) | 2014-06-25 | 2023-07-31 | 이에이 파마 가부시키가이샤 | Solid preparation, and method for preventing or reducing discoloration thereof |
EP3012252A1 (en) | 2014-10-24 | 2016-04-27 | Ferring BV | Crystal modifications of elobixibat |
BR112017009657A2 (en) | 2014-11-06 | 2018-01-23 | Enanta Pharmaceuticals, Inc | bile acid analogues as fxr / tgr5 agonists and methods of using them |
US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
SG11201703997XA (en) * | 2014-11-26 | 2017-06-29 | Enanta Pharm Inc | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
MX2017010376A (en) | 2015-02-11 | 2017-12-20 | Enanta Pharm Inc | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof. |
WO2016161003A1 (en) | 2015-03-31 | 2016-10-06 | Enanta Phamraceuticals, Inc. | Bile acid derivatives as fxr/tgr5 agonists and methods of use thereof |
WO2016173397A1 (en) * | 2015-04-28 | 2016-11-03 | 上海翰森生物医药科技有限公司 | Cholic acid derivative, and preparation method and medical use thereof |
US10441604B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Cholestyramine pellets and methods for preparation thereof |
WO2017138877A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10786529B2 (en) | 2016-02-09 | 2020-09-29 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10441605B2 (en) | 2016-02-09 | 2019-10-15 | Albireo Ab | Oral cholestyramine formulation and use thereof |
WO2017138878A1 (en) | 2016-02-09 | 2017-08-17 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US10323061B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as FXR/TGR5 agonists and methods of use thereof |
WO2017147137A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as fxr/tgr5 agonists and methods of use thereof |
EP3548038B1 (en) | 2016-11-29 | 2022-04-13 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
US10472386B2 (en) | 2017-02-14 | 2019-11-12 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR agonists and methods of use thereof |
BR112019020780A2 (en) | 2017-04-07 | 2020-04-28 | Enanta Pharm Inc | process for preparing sulfonyl carbamate bile acid derivatives |
EP3664781A1 (en) | 2017-08-09 | 2020-06-17 | Albireo AB | Cholestyramine granules, oral cholestyramine formulations and use thereof |
CA3071182A1 (en) | 2017-08-09 | 2019-02-14 | Albireo Ab | Cholestyramine pellets, oral cholestyramine formulations and use thereof |
US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
JP7391048B2 (en) | 2018-06-05 | 2023-12-04 | アルビレオ・アクチボラグ | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2019245448A1 (en) | 2018-06-20 | 2019-12-26 | Albireo Ab | Crystal modifications of odevixibat |
US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
CN113301901B (en) * | 2019-01-14 | 2022-09-09 | 北京轩义医药科技有限公司 | Tetrazolinone substituted steroids and uses thereof |
CA3127408A1 (en) | 2019-02-06 | 2020-08-13 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
RS63899B1 (en) | 2019-02-06 | 2023-02-28 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
TW202134221A (en) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | Benzothiadiazepine compounds and their use as bile acid modulators |
TW202134218A (en) | 2019-12-04 | 2021-09-16 | 瑞典商艾爾比瑞歐公司 | Benzothiazepine compounds and their use as bile acid modulators |
CR20220315A (en) | 2019-12-04 | 2022-10-26 | Albireo Ab | BENZOTI(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS |
AR120683A1 (en) | 2019-12-04 | 2022-03-09 | Albireo Ab | BENZOTHI(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILIARY ACID |
WO2021110886A1 (en) | 2019-12-04 | 2021-06-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
US11014898B1 (en) | 2020-12-04 | 2021-05-25 | Albireo Ab | Benzothiazepine compounds and their use as bile acid modulators |
EP4069361B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
CN114761018A (en) | 2019-12-04 | 2022-07-15 | 阿尔比里奥公司 | Benzothiadiazepine compounds and their use as bile acid modulators |
EP4069359B1 (en) | 2019-12-04 | 2024-01-03 | Albireo AB | Benzothia(di)azepine compounds and their use as bile acid modulators |
PT4069360T (en) | 2019-12-04 | 2024-03-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2022029101A1 (en) | 2020-08-03 | 2022-02-10 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
CN116157389A (en) | 2020-08-03 | 2023-05-23 | 阿尔比里奥公司 | Benzothiazepine compounds and their use as bile acid modulators |
JP2023549226A (en) | 2020-11-12 | 2023-11-22 | アルビレオ エービー | Odevixibat for the treatment of progressive familial intrahepatic cholestasis (PFIC) |
CA3198216A1 (en) | 2020-12-04 | 2022-06-09 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
TW202313579A (en) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | Benzothia(di)azepine compounds and their use as bile acid modulators |
WO2023203248A1 (en) | 2022-04-22 | 2023-10-26 | Albireo Ab | Subcutaneous administration of an asbt inhibitor |
WO2023237097A1 (en) * | 2022-06-09 | 2023-12-14 | 山东绿叶制药有限公司 | 19-nor-c3,3-disubstituted c21-azacyclo-substituted steroid and method for using same |
US20230398125A1 (en) | 2022-06-09 | 2023-12-14 | Albireo Ab | Treating hepatitis |
WO2024008766A1 (en) | 2022-07-05 | 2024-01-11 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3930696A1 (en) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | GALLENSAEUREDERIVATE, METHOD FOR THE PRODUCTION THEREOF, USE AS MEDICAMENT |
DK0489423T3 (en) * | 1990-12-06 | 1997-04-14 | Hoechst Ag | Bile acid derivatives, processes for their preparation and the use of these compounds as drugs |
-
1993
- 1993-11-23 TW TW082109825A patent/TW289757B/zh active
-
1994
- 1994-05-02 EP EP94106848A patent/EP0624596B1/en not_active Expired - Lifetime
- 1994-05-02 ES ES94106848T patent/ES2115096T3/en not_active Expired - Lifetime
- 1994-05-02 DE DE59405410T patent/DE59405410D1/en not_active Expired - Lifetime
- 1994-05-02 DK DK94106848T patent/DK0624596T3/en active
- 1994-05-02 AT AT94106848T patent/ATE163938T1/en not_active IP Right Cessation
- 1994-05-05 US US08/238,741 patent/US5466815A/en not_active Expired - Lifetime
- 1994-05-05 FI FI942075A patent/FI942075A/en unknown
- 1994-05-06 IL IL109581A patent/IL109581A/en not_active IP Right Cessation
- 1994-05-06 CZ CZ19941135A patent/CZ289515B6/en not_active IP Right Cessation
- 1994-05-06 JP JP09442494A patent/JP3476157B2/en not_active Expired - Fee Related
- 1994-05-06 AU AU61947/94A patent/AU666440B2/en not_active Ceased
- 1994-05-06 NO NO934800A patent/NO304795B1/en not_active IP Right Cessation
- 1994-05-06 HU HU9401443A patent/HU217439B/en not_active IP Right Cessation
- 1994-05-06 NZ NZ260469A patent/NZ260469A/en unknown
- 1994-05-06 CA CA002123048A patent/CA2123048C/en not_active Expired - Fee Related
- 1994-05-07 KR KR1019940009971A patent/KR100333149B1/en not_active IP Right Cessation
-
1998
- 1998-04-03 GR GR980400679T patent/GR3026496T3/en unknown
- 1998-09-29 CY CY9800037A patent/CY2119B1/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO304795B1 (en) | 1999-02-15 |
DK0624596T3 (en) | 1998-10-07 |
AU6194794A (en) | 1994-11-10 |
IL109581A (en) | 1998-03-10 |
US5466815A (en) | 1995-11-14 |
EP0624596A3 (en) | 1995-06-07 |
NO941677L (en) | 1994-11-09 |
ATE163938T1 (en) | 1998-03-15 |
JPH06329695A (en) | 1994-11-29 |
DE59405410D1 (en) | 1998-04-16 |
NZ260469A (en) | 1995-03-28 |
KR100333149B1 (en) | 2002-09-19 |
HU217439B (en) | 2000-01-28 |
FI942075A0 (en) | 1994-05-05 |
NO941677D0 (en) | 1994-05-06 |
FI942075A (en) | 1994-11-09 |
ES2115096T3 (en) | 1998-06-16 |
HUT67390A (en) | 1995-04-28 |
TW289757B (en) | 1996-11-01 |
GR3026496T3 (en) | 1998-07-31 |
JP3476157B2 (en) | 2003-12-10 |
IL109581A0 (en) | 1994-08-26 |
AU666440B2 (en) | 1996-02-08 |
CZ289515B6 (en) | 2002-02-13 |
HU9401443D0 (en) | 1994-08-29 |
EP0624596B1 (en) | 1998-03-11 |
CA2123048C (en) | 2005-11-29 |
EP0624596A2 (en) | 1994-11-17 |
CZ113594A3 (en) | 1994-12-15 |
CY2119B1 (en) | 2002-04-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |
Effective date: 20140506 |