CA2124519A1 - Mouthpiece for inhalation therapy device - Google Patents
Mouthpiece for inhalation therapy deviceInfo
- Publication number
- CA2124519A1 CA2124519A1 CA002124519A CA2124519A CA2124519A1 CA 2124519 A1 CA2124519 A1 CA 2124519A1 CA 002124519 A CA002124519 A CA 002124519A CA 2124519 A CA2124519 A CA 2124519A CA 2124519 A1 CA2124519 A1 CA 2124519A1
- Authority
- CA
- Canada
- Prior art keywords
- mouthpiece
- opening
- valve element
- basic body
- inhalation therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K15/00—Check valves
- F16K15/14—Check valves with flexible valve members
- F16K15/16—Check valves with flexible valve members with tongue-shaped laminae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0013—Details of inhalators; Constructional features thereof with inhalation check valves
- A61M15/0015—Details of inhalators; Constructional features thereof with inhalation check valves located upstream of the dispenser, i.e. not traversed by the product
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0001—Details of inhalators; Constructional features thereof
- A61M15/0018—Details of inhalators; Constructional features thereof with exhalation check valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/208—Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/06—Sprayers or atomisers specially adapted for therapeutic purposes of the injector type
Abstract
Abstract MOUTHPIECE FOR INHALATION THERAPY DEVICES
The invention concerns a mouthpiece for inhalation therapy devices. An opening (14) is located on the basic body (1) of the mouthpiece for exhalation into the mouthpiece so that the exhaled air can escape through it. The opening (14) is covered by a flat, elastic valve element (12) of a nonreturn valve (11) in such a manner that, for the most part, a simulation of the missing wall of the basic body (1) in the area of the opening (14) is achieved. This insures that the flow conditions in the interior of the mouthpiece remain nearly unaffected by the opening (14) when, during inhalation, the flat, elastic valve element (12) lies flat on a level wall section of the basic body (1) and closes the opening (14).
The invention concerns a mouthpiece for inhalation therapy devices. An opening (14) is located on the basic body (1) of the mouthpiece for exhalation into the mouthpiece so that the exhaled air can escape through it. The opening (14) is covered by a flat, elastic valve element (12) of a nonreturn valve (11) in such a manner that, for the most part, a simulation of the missing wall of the basic body (1) in the area of the opening (14) is achieved. This insures that the flow conditions in the interior of the mouthpiece remain nearly unaffected by the opening (14) when, during inhalation, the flat, elastic valve element (12) lies flat on a level wall section of the basic body (1) and closes the opening (14).
Description
212~9 -- PAUL RITZAU PARI-WERK GmbH ~ u~ -Moosstrasse 9, D-82319 Starnberg .... ~- .
DESCRIPTION
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MOUTHPIECE FOR INHALATION THERAPY DEVICE ;; ~
~ . ~
~`..
The invention in question concerns a mouthpiece for inhalation therapy devices.
An inhalation therapy device for which the mouthpiece as per the invention can be used, is, for example, known from EP 87 13 416.1. The device has a nebulizer with a ~``"`~.
chimney~for en rained air and a nebulization chamber in which a nebulization nozle ` - h produces an aerosol containing medication. The aerosol consists of a fine droplet or partical mist which is inhaled by the patient. Thè known inhalation therapy device has a mouthpiece which is inserted on the outlet connection of the nebulizer and through "~
which th~pàtient inhal~s the aerosol. Thus, surrounding air flows through the entrained` air~chimney and the nebulization chamber into the mouthpiece. When exhalin~ into the mouthpiece, a nonreturn valve in the entrained air chimney of the nebulizèr~closes. In order to make exhalation through the mouthpiece possible `~
anyway,`a nonr~eturn valve on the familiar mouthpiece which opens during exhalation ` -`~
is locàted on the branched-off tube-shaped connection through which the air leaves to the: surroundings. ~
In the known moùthpiece a very large dead space exists in the area of the nonreturn valve~which~allows the~aerosol droplets or particles to separate. Above and beyond this, the~vèry large~ dead space negàtive~ influen s the flow relationships in the mouthpiece and thereby the composition of the aerosol inhaled by the patien~
Therefore,iit is-the~job`of this invention to make a~mouthpiece for inhalation therapy devicès which doès not inflùence the aerosol flow~during inhalation, spec fically prevents a`sepàration of the aerosol and also ~allows exhalation into the mouthpiece. ~
This task is~ solved by a mouthpiece for inhalation therapy devices with a basic body of a rnostl~tube-shaped shape in whose wall there is an opening and a nonreturn valve for~sealing the opening during inhalation through the mouthpiece and for allowing the exhaled `air through the opening during exhalation through the~mouthpiecs. The rnouthpiecè~as~per the`in~ention is~ characterized in that the basic body has at least one~mostly level ~vall in which the opèning is located and the nonreturnvalve has a flàt, elastic valve element whose~dimensions and shape for closing the opening are adàpted to it and which is fastened onto the leve! wall portion in such a manner that, due to~t~hè effective èlastic forces, it lies on the exterior of the basic body during rest ".i .
DESCRIPTION
' ,,:, ,''.~.
MOUTHPIECE FOR INHALATION THERAPY DEVICE ;; ~
~ . ~
~`..
The invention in question concerns a mouthpiece for inhalation therapy devices.
An inhalation therapy device for which the mouthpiece as per the invention can be used, is, for example, known from EP 87 13 416.1. The device has a nebulizer with a ~``"`~.
chimney~for en rained air and a nebulization chamber in which a nebulization nozle ` - h produces an aerosol containing medication. The aerosol consists of a fine droplet or partical mist which is inhaled by the patient. Thè known inhalation therapy device has a mouthpiece which is inserted on the outlet connection of the nebulizer and through "~
which th~pàtient inhal~s the aerosol. Thus, surrounding air flows through the entrained` air~chimney and the nebulization chamber into the mouthpiece. When exhalin~ into the mouthpiece, a nonreturn valve in the entrained air chimney of the nebulizèr~closes. In order to make exhalation through the mouthpiece possible `~
anyway,`a nonr~eturn valve on the familiar mouthpiece which opens during exhalation ` -`~
is locàted on the branched-off tube-shaped connection through which the air leaves to the: surroundings. ~
In the known moùthpiece a very large dead space exists in the area of the nonreturn valve~which~allows the~aerosol droplets or particles to separate. Above and beyond this, the~vèry large~ dead space negàtive~ influen s the flow relationships in the mouthpiece and thereby the composition of the aerosol inhaled by the patien~
Therefore,iit is-the~job`of this invention to make a~mouthpiece for inhalation therapy devicès which doès not inflùence the aerosol flow~during inhalation, spec fically prevents a`sepàration of the aerosol and also ~allows exhalation into the mouthpiece. ~
This task is~ solved by a mouthpiece for inhalation therapy devices with a basic body of a rnostl~tube-shaped shape in whose wall there is an opening and a nonreturn valve for~sealing the opening during inhalation through the mouthpiece and for allowing the exhaled `air through the opening during exhalation through the~mouthpiecs. The rnouthpiecè~as~per the`in~ention is~ characterized in that the basic body has at least one~mostly level ~vall in which the opèning is located and the nonreturnvalve has a flàt, elastic valve element whose~dimensions and shape for closing the opening are adàpted to it and which is fastened onto the leve! wall portion in such a manner that, due to~t~hè effective èlastic forces, it lies on the exterior of the basic body during rest ".i .
2~2 1~19 and closes the opening, and that, in order to open the opening, it can be partially lifted from the basic body.
In an advantageous design the basic body has a connection area for connecting the mouthpiece on the inhalation therapy device, has an ergonomically shaped area for placing in the mouth and a transition area for transforming the shape of the connection area into the shape of the ergonomically shaped portion, and is located in ;`
the mostly level wall portion in which the opeing is located in the transition area. ` -Furthermore, the flat elastic valve element can be held on the basic body from the ;~
outside by a clamp assembly.
In another design, the clamp assembly has an one-piece valve element cover which is locatad on the outside of the basic body over the vaive element and serves to protect ~ ~
the flat, elastic valve element. :-. .:. . -Above and beyond this, in the mouthpiece as per the inventionl the opening can be equipped with a circumferential peripheral step which protrudes into the opening and - --on which the flat, elastic valve element lies in its normal position so that the flat, elastic valve element is mostly situated in the opening. Beneficial is to equip the peripheral r- `
step with a circumferential sealing lip.
The mouthpiece as per the invention can finally be designed in such a way that the flat elastic valve element has a restraining opening, that the basic body has a restraining ` ~
opening and that the clamp assembly is hinged so that it can flap from an open ~ :
position to a valve-element-clamping position and has a restraining projection. - -The flat elastic valve element is made of a plastic or rubber material. ~;} ~ ~`
: .. :.;
As per the invention the wall of the mouthpiece basic body is simulated by a flat elastic valve element in the area of the opening. In the area of the opening the inner surface -~
of the mouthpiece basic body is practically replaced by the surface of the flat elastic -valve element pointing toward the inside. This has the effect that the dead space in the area of the valve is reduced considerably and, due to the similation of the inner wall, there is practically no influence on the flow in the mouthpiece. ` -The invention will be described below based on application examples which are ~-shown in the drawings. The drawings show the following~
Fig. 1 a first application example of the mouthpiece as per the invention on an ~ ~ -exemplary nebulizers shown in its cross section;
Fig.2 a second design example of the mouthpiece as per the invention in a cross ~ ;
sectional view;
. -, . ~
~12~19 . . .
Fig. 3 a perspective view of a third application example of the mouthpieces as per the invention, and Fig. 4 an enlarged view of a detail of the third application example. `~
With reference to Fig. 1 first, the basics of the design and function of the mouthpiece 1 as per the invention which, in Fig. 1 's view, is placed on an intake connection 2 of a -nebulizer 3, will b~ described. Naturally, the mouthpiece as per the invention can be used together with other inhalation therapy devices which produce an aerosol for the -patient to inhale. :
The exemplary nebulizer 3 chosen has an entrained air chimney 4 through which ambient air is sucked into the nebulization chamber 5 during inhalation. In the nebulization chamber a nozzle 6 produces an aerosol from a powder or liquid nebulization substance, specifically a medication which is stored at the lower end of nozle 6 in a nebulization substance reservoir 7. In order to produce aerosol compressed air is forced through a compressed air channel 8 in the nozle 6 which ~ ~ ~Y
exits at the upper end of the nozle and nebulization substance is sucked through the two nebulization substance channels which are located on both sides of the compressed air channel. Supported by an air flow control 9 with ba~fle edge, aerosol, which is stored in the`nebulization chamber 5, is produced by nebulization. Aerosol can be produced continuously or shortly before or during inhalation. For continuous aerosol production a continuous compressed air flow is forced through the compressed air channel 8 of the nozle 6. In this case the entrained air chimney 4 is closed to the surroundings by a nonreturn valve 10 which prevents the aerosol proquced in the nebulization chamber ~ from exiting through the entrained air chimney 4.
During inhalation the patient sucks the aerosol stored in the nebulization chamber 5 through the mouthpiece 1 and the intake connection 2. Due to the negative pressure produced, ambient airflows through the opened nonreturn valve 10 viathe entrained air chimney 4 into the nebulization chamber 5 and is then sucked through the mouthpiece 1 and the intake connection 2. During continuous nebulization the ~ ~ -surrounding air mixes continuously with the produced aerosol. The flow cross sections of the entrained air chimney 4, the nebulization chamber 5 and the intake connection 2 as well as the behaviour of the nonreturn valve 10 are adapted to the nebulization performance of the nozle 6 in such a way that an aerosol of desiredconcentration and particle distribution can be inhaled by the patient during inhalation. ;
No further ambient air should be added to the sucked aerosol in the area of the ;~
mouthpiece 1 and the intake connection 2 in order to insure a maximum output of the nebulization substance with the help of the entrained air. Ab~ve and beyond ~his a flow-favorable geometry in the inside of the mouthpiece is strived for in order to prevent unwanted vorticities and inhomogenities in the aerosol. For inhalation, an -ideal mouthpiece therefore has the shape of a closed, mainly tube-shaped basic ~ ~ ~
2 1 2 Ll ~ 1 9 body, in which the cross sections and cross section shapes change continuously. ~
The cross section surFace remains the same or becomes smaller in the direction of ~ -flow during inhalation. In such a design the flow is not turbulent and the deposition of the aerosol droplets and/or particles is minimized.
During exhalation however, the exhaled air must not flow into the surrounding in a - ` ~
reverse direction since exhalation through intake connection 2, nebulization chamber `; -5 and entrained air chimney 4 would lead to the continuously produced aerosol or at least aerosol residues from the nebulization chamber 5 being forced out whereby the nebulization substance, in the form of the aerosol, would be lost. This is the reason for -the nonreturn valve 10 which closes the entrained air chimney during exhalation so ;
that exhalation through the entrained air chimney 4 and therefore through the ;
nebulization chamber 5 is not possible. ;
., . ., -,.
However, in order to make exhalation through the mouthpiece possible for the patient, the mouthpiece 1 has a valve 11. In the invention this valve is designed such that it `- -~
simulates the wall of an ideal mouthpiece as far as possible. The basic idea of the i~
invention is to equip a mouthpiece with a valve in such a manner that the wall of the -- -mouthpiece at tha location of the opening of the valve is simulated by an elastic valve ~ : ~
element in such a manner that the deviation from the originally existing wall is as small --as possible. Thus, as per the invention, the lowest possible influence of the flow relationships is achieved and the deposition of aerosol droplets or particles isavoided. .. -~".' . ,;`~..
~th this in mind, the mouthpiece 1 of the first application example is divided into three ~ -part~ 1a, lb and 1c. The valve is located in part lb, which is a transition between la - `
and 1c. Part la of the mouthpiece 1 is mainly circular cylindrical and adapted to the - ` n tube-shaped intake connection 2 of the inhalation therapy device. Thus, the ~ -mouthpiece 1 can be placed on intake connection 2 in such a manner thatl first off a secure ft is insured and, secondly, an unwanted influx of ambient air is prevented due to the achievable air-tightness at the mounting site ~a. In part 1c the mouthpieca is flatted for ergonomic reasons and, for example, has a mainly elliptical cross section. ` -Part 1 b lies between parts 1 a and 1 c and converts the shape from one to the other in a flwx-favorable manner. As per the invention mouthpiece 1 has an at least one mainly level wall surface in zone 1 b in which the opening 14 for tha breathed air during exhàlation is located and in whose immediate zone valve 11 is located. -In the application example shown in Fig. 1 the valve 11 consists of a flat elastic element 12 which is fastened on one end to the exterior of the mouthpiece 1 by aclamp assembly. The free end of the elastic element 12 lies flat on the level wall surface of zone 1 b durîng rest and closes the opening 14 located in this zone. For this the elastic element 12 has the corresponding dimensions and a shape adapted to the -opening 14. The ciamp assembly is not located in the area of the level wall surfaces but rather in their \licinity so that the valve element 12 is held and for which it extends to the clamp assembly.
In Fig. 1 the elastic element 12 is shown in a raised position which occurs when the patient exhales through the mouthpiece 1. When inhaling through the mouthpiece 1the negative pressur~ arising in the mouthpiece supports the elastic forces which make the elastic valve element 12 close the opening 14 in the mouthpiece during rest.
Thus, no surrounding air can enter through the opening 1~ in the mouthpiece during inhalation thereby mixing with the sucked aerosol.
As per the invention the elastic element 12 is situated on the level wall portion of the zone 1 b of the mouthpiece in such a way that the wall portion missing in the area of opening 14 of the mouthpiece 1 is replaced by the elastic element 12. Only the volume which results from the opening surface of the opening 14 and the wall thickness of the mouthpiece 1, influences the flow relationships in mouthpiece 1 in the valve 11 as per the invention. However, due to the design of the mouthpiece valve 11 as per the invention, this volume is already very small in this application so that the flow ~.
relationships correspond entirely to the flow relationships of a mouthpiece without an ~ `
opening. The volume in the area of opening 14 is so small that nearly none of the droplets or particles in the aerosol separate. The flow is not influenced worth mentioning by the dead space in the area of the valve. In the end, during inhalation -the mouthpiece as per the invention behaves as R the opening 14 did not exist. Thus, the mouthpiece as per the invention corresponds mostly to the above mentioned ideal situation.
Fig. 2 shows a second application example of the mouthpiece 1 for an inhalation therapy device as per the invention for which only a portion of the intake connection 2 is sh'own. In the second application example the elastic valve element 12 is shown in the resting position in which the opening 14 is covered. From ~ig. 2 one can see that the dead space determined by the opening 14 and the elastic valve element 12 in its resting position, is nearly completely eliminated For this, the elastic valve element 12 has two layers. The first layer 1 2a, which, due to its inherent elastic forces in its resting position forces the valve element to lie on basic body 1, corresponds fqr the most part to the elastic valve element 12 of the first application example. Above and beyond this in the seGond application example the valve element 12 has a second layer 12b which is located on the side of the first layer 12a facing the opening 14 and whose shape and dimensions are adapted to the opening 14 is such a way that this part of the valve element can be arranged in the opening and that a movement of the valve element 12 ~ -is possible anyway through which the opening 14 is opened during exhalation. The ~ ~-thickness of layer 12b of the valve element 12 corresponds to the wall thickness of the - ;
basic body 1 of the mouthpiece. Therefore in the resting position the opening 14 in basic body 1 is close`d in such a way that the inner wall of the basic body 1 continues nearly without interruption in thatthe surface of the second layer 12b facing toward the inside simulates the inner wall of the basic body 1. Both layers 1 2a and 1 2b can be of the same material and made as a single piece or of different materials. ~i 2~2~19 :
:~.
As in the first application example the elastic valve element 12 is fastened to mouthpiece 1 by means of a clamp assembly 13. However, in comparison with the - ;
first application example, the second application example as per Fig. 2 has a single-piece valve element cover 13a tip-stretched on the clamp assembly 13 which is iocated above the valve element and has, for the most part, the same shape as the -elastic valve element 12. The valve cover 13a's job is to protect the elastic valve -element 12 against contact and damage. In order to allow the elastic valve element 12 to move during inhalation, the valve cover 13a is bent away from the wall piece of zone 1b of mouthpiece 1 which contains the opening 11. The resulting opening angle can be chosen freely in wide ranges as long as it is insured that the elastic valve element 12 can move sufficiently enough that the opening is opened during exhalation . . ,. :,: ' ,~
Fig. 3 shows a third application example of the mouthpiece as per the invention. Just -like in the first and second application examples, the mouthpiece has three zones 1 a, ;
1 b and 1 c. Zone 1 a serves to secure the mouthpiece on the inhalation therapy device and has a tube-shaped design. Zone 1 b is the transition to the ergonomically shaped - `
zone 1c. An opening 14 in a mainly level wall portion of the mouthpiece 1 is located in ; ` ~;
zone 1 b. An elastic valve platelet 12 is shown in its raised position. When assembled, the elastic valve platelet 12 is located on the mouthpiece 1 in such a manner that a -restraining opening 15l which is located in the elastic valve platelet 12, lies over a restraining opening 16 in the basic body 1 of the mouthpiece. The elasticvalve platelet 12 then covers the opening 14 of the mouthpiece 1 whereby the outer edge of the movable part of the valva platelet 12 lies on the opening 14. ~ -For ~larification, Fig. 4 shows an enlarged view of the part of the mouthpiece marked by reference letter A in Fig. 3. One can see that opening 14 has a circum~erential peripheral step 14a on the lower wall section which protrudes into opening 14 and on which the elastic valve platelet 12 lies during rest and inhalation phases. Due to this design, the dead space in the area of the mouthpiece valve is reduced to the volume defined by the thickness of the edge, marked by reference letter d, and the surface of the opening 14.
.-~
The circumferential peripheral step 14a can have a circumferential sealing lip in the ;
immediate vicinity of the opening 14 which protrudes from the surface of the peripheral step facing the valve platelet; however, the sealing lip is not shown in Fig. 4.
In this case the elastic valve platelet is Iying on the sealing lip.
The elastic valve platelet 12 has a thickness which is not greater that the remaining edge area on which the edge of the elastic valve platelet 12 borders in its resting -~
position. Thus, during rest, the platelet 12 does not protrude out of the surFace of the - ~ `
mouthpiece1.
Clamp assembly 13 is in the form of a bracket which can be designed as a single piece with the basic body 1 of the mouthpiece for restrainment. A hinge allows the -~ , .
2121~19 ,. . .
clamp b~acket to be raised upward as shown in Flg. 3. The valve platelet 12 Is then brought to the assembly position and the clamp brackett 13 is closed. A restraining projection 13b on the side f the clamp bracket toward the valve platelet grips into the restraining openings 15 and 16 in the valve platelet 12 and/or basic body 1. By chosing the dimensions correctly, a sure fixation of the valve platelet is insured which is positioned based on the restraining projection 13b and clamped by the clamp brackett 13b. However, the valve platelet 12 remains flexible in the area of the opening 14 so that air can flow through the opening 14 during exhalation.
A cover 13a on the clamp brackett located above the elastic valve platelet as in the second application example, serves to protect the elastic valve platelet from contact and damages when the clamp brackett 13 clamps the valve platelet 12.
. . .- ,
In an advantageous design the basic body has a connection area for connecting the mouthpiece on the inhalation therapy device, has an ergonomically shaped area for placing in the mouth and a transition area for transforming the shape of the connection area into the shape of the ergonomically shaped portion, and is located in ;`
the mostly level wall portion in which the opeing is located in the transition area. ` -Furthermore, the flat elastic valve element can be held on the basic body from the ;~
outside by a clamp assembly.
In another design, the clamp assembly has an one-piece valve element cover which is locatad on the outside of the basic body over the vaive element and serves to protect ~ ~
the flat, elastic valve element. :-. .:. . -Above and beyond this, in the mouthpiece as per the inventionl the opening can be equipped with a circumferential peripheral step which protrudes into the opening and - --on which the flat, elastic valve element lies in its normal position so that the flat, elastic valve element is mostly situated in the opening. Beneficial is to equip the peripheral r- `
step with a circumferential sealing lip.
The mouthpiece as per the invention can finally be designed in such a way that the flat elastic valve element has a restraining opening, that the basic body has a restraining ` ~
opening and that the clamp assembly is hinged so that it can flap from an open ~ :
position to a valve-element-clamping position and has a restraining projection. - -The flat elastic valve element is made of a plastic or rubber material. ~;} ~ ~`
: .. :.;
As per the invention the wall of the mouthpiece basic body is simulated by a flat elastic valve element in the area of the opening. In the area of the opening the inner surface -~
of the mouthpiece basic body is practically replaced by the surface of the flat elastic -valve element pointing toward the inside. This has the effect that the dead space in the area of the valve is reduced considerably and, due to the similation of the inner wall, there is practically no influence on the flow in the mouthpiece. ` -The invention will be described below based on application examples which are ~-shown in the drawings. The drawings show the following~
Fig. 1 a first application example of the mouthpiece as per the invention on an ~ ~ -exemplary nebulizers shown in its cross section;
Fig.2 a second design example of the mouthpiece as per the invention in a cross ~ ;
sectional view;
. -, . ~
~12~19 . . .
Fig. 3 a perspective view of a third application example of the mouthpieces as per the invention, and Fig. 4 an enlarged view of a detail of the third application example. `~
With reference to Fig. 1 first, the basics of the design and function of the mouthpiece 1 as per the invention which, in Fig. 1 's view, is placed on an intake connection 2 of a -nebulizer 3, will b~ described. Naturally, the mouthpiece as per the invention can be used together with other inhalation therapy devices which produce an aerosol for the -patient to inhale. :
The exemplary nebulizer 3 chosen has an entrained air chimney 4 through which ambient air is sucked into the nebulization chamber 5 during inhalation. In the nebulization chamber a nozzle 6 produces an aerosol from a powder or liquid nebulization substance, specifically a medication which is stored at the lower end of nozle 6 in a nebulization substance reservoir 7. In order to produce aerosol compressed air is forced through a compressed air channel 8 in the nozle 6 which ~ ~ ~Y
exits at the upper end of the nozle and nebulization substance is sucked through the two nebulization substance channels which are located on both sides of the compressed air channel. Supported by an air flow control 9 with ba~fle edge, aerosol, which is stored in the`nebulization chamber 5, is produced by nebulization. Aerosol can be produced continuously or shortly before or during inhalation. For continuous aerosol production a continuous compressed air flow is forced through the compressed air channel 8 of the nozle 6. In this case the entrained air chimney 4 is closed to the surroundings by a nonreturn valve 10 which prevents the aerosol proquced in the nebulization chamber ~ from exiting through the entrained air chimney 4.
During inhalation the patient sucks the aerosol stored in the nebulization chamber 5 through the mouthpiece 1 and the intake connection 2. Due to the negative pressure produced, ambient airflows through the opened nonreturn valve 10 viathe entrained air chimney 4 into the nebulization chamber 5 and is then sucked through the mouthpiece 1 and the intake connection 2. During continuous nebulization the ~ ~ -surrounding air mixes continuously with the produced aerosol. The flow cross sections of the entrained air chimney 4, the nebulization chamber 5 and the intake connection 2 as well as the behaviour of the nonreturn valve 10 are adapted to the nebulization performance of the nozle 6 in such a way that an aerosol of desiredconcentration and particle distribution can be inhaled by the patient during inhalation. ;
No further ambient air should be added to the sucked aerosol in the area of the ;~
mouthpiece 1 and the intake connection 2 in order to insure a maximum output of the nebulization substance with the help of the entrained air. Ab~ve and beyond ~his a flow-favorable geometry in the inside of the mouthpiece is strived for in order to prevent unwanted vorticities and inhomogenities in the aerosol. For inhalation, an -ideal mouthpiece therefore has the shape of a closed, mainly tube-shaped basic ~ ~ ~
2 1 2 Ll ~ 1 9 body, in which the cross sections and cross section shapes change continuously. ~
The cross section surFace remains the same or becomes smaller in the direction of ~ -flow during inhalation. In such a design the flow is not turbulent and the deposition of the aerosol droplets and/or particles is minimized.
During exhalation however, the exhaled air must not flow into the surrounding in a - ` ~
reverse direction since exhalation through intake connection 2, nebulization chamber `; -5 and entrained air chimney 4 would lead to the continuously produced aerosol or at least aerosol residues from the nebulization chamber 5 being forced out whereby the nebulization substance, in the form of the aerosol, would be lost. This is the reason for -the nonreturn valve 10 which closes the entrained air chimney during exhalation so ;
that exhalation through the entrained air chimney 4 and therefore through the ;
nebulization chamber 5 is not possible. ;
., . ., -,.
However, in order to make exhalation through the mouthpiece possible for the patient, the mouthpiece 1 has a valve 11. In the invention this valve is designed such that it `- -~
simulates the wall of an ideal mouthpiece as far as possible. The basic idea of the i~
invention is to equip a mouthpiece with a valve in such a manner that the wall of the -- -mouthpiece at tha location of the opening of the valve is simulated by an elastic valve ~ : ~
element in such a manner that the deviation from the originally existing wall is as small --as possible. Thus, as per the invention, the lowest possible influence of the flow relationships is achieved and the deposition of aerosol droplets or particles isavoided. .. -~".' . ,;`~..
~th this in mind, the mouthpiece 1 of the first application example is divided into three ~ -part~ 1a, lb and 1c. The valve is located in part lb, which is a transition between la - `
and 1c. Part la of the mouthpiece 1 is mainly circular cylindrical and adapted to the - ` n tube-shaped intake connection 2 of the inhalation therapy device. Thus, the ~ -mouthpiece 1 can be placed on intake connection 2 in such a manner thatl first off a secure ft is insured and, secondly, an unwanted influx of ambient air is prevented due to the achievable air-tightness at the mounting site ~a. In part 1c the mouthpieca is flatted for ergonomic reasons and, for example, has a mainly elliptical cross section. ` -Part 1 b lies between parts 1 a and 1 c and converts the shape from one to the other in a flwx-favorable manner. As per the invention mouthpiece 1 has an at least one mainly level wall surface in zone 1 b in which the opening 14 for tha breathed air during exhàlation is located and in whose immediate zone valve 11 is located. -In the application example shown in Fig. 1 the valve 11 consists of a flat elastic element 12 which is fastened on one end to the exterior of the mouthpiece 1 by aclamp assembly. The free end of the elastic element 12 lies flat on the level wall surface of zone 1 b durîng rest and closes the opening 14 located in this zone. For this the elastic element 12 has the corresponding dimensions and a shape adapted to the -opening 14. The ciamp assembly is not located in the area of the level wall surfaces but rather in their \licinity so that the valve element 12 is held and for which it extends to the clamp assembly.
In Fig. 1 the elastic element 12 is shown in a raised position which occurs when the patient exhales through the mouthpiece 1. When inhaling through the mouthpiece 1the negative pressur~ arising in the mouthpiece supports the elastic forces which make the elastic valve element 12 close the opening 14 in the mouthpiece during rest.
Thus, no surrounding air can enter through the opening 1~ in the mouthpiece during inhalation thereby mixing with the sucked aerosol.
As per the invention the elastic element 12 is situated on the level wall portion of the zone 1 b of the mouthpiece in such a way that the wall portion missing in the area of opening 14 of the mouthpiece 1 is replaced by the elastic element 12. Only the volume which results from the opening surface of the opening 14 and the wall thickness of the mouthpiece 1, influences the flow relationships in mouthpiece 1 in the valve 11 as per the invention. However, due to the design of the mouthpiece valve 11 as per the invention, this volume is already very small in this application so that the flow ~.
relationships correspond entirely to the flow relationships of a mouthpiece without an ~ `
opening. The volume in the area of opening 14 is so small that nearly none of the droplets or particles in the aerosol separate. The flow is not influenced worth mentioning by the dead space in the area of the valve. In the end, during inhalation -the mouthpiece as per the invention behaves as R the opening 14 did not exist. Thus, the mouthpiece as per the invention corresponds mostly to the above mentioned ideal situation.
Fig. 2 shows a second application example of the mouthpiece 1 for an inhalation therapy device as per the invention for which only a portion of the intake connection 2 is sh'own. In the second application example the elastic valve element 12 is shown in the resting position in which the opening 14 is covered. From ~ig. 2 one can see that the dead space determined by the opening 14 and the elastic valve element 12 in its resting position, is nearly completely eliminated For this, the elastic valve element 12 has two layers. The first layer 1 2a, which, due to its inherent elastic forces in its resting position forces the valve element to lie on basic body 1, corresponds fqr the most part to the elastic valve element 12 of the first application example. Above and beyond this in the seGond application example the valve element 12 has a second layer 12b which is located on the side of the first layer 12a facing the opening 14 and whose shape and dimensions are adapted to the opening 14 is such a way that this part of the valve element can be arranged in the opening and that a movement of the valve element 12 ~ -is possible anyway through which the opening 14 is opened during exhalation. The ~ ~-thickness of layer 12b of the valve element 12 corresponds to the wall thickness of the - ;
basic body 1 of the mouthpiece. Therefore in the resting position the opening 14 in basic body 1 is close`d in such a way that the inner wall of the basic body 1 continues nearly without interruption in thatthe surface of the second layer 12b facing toward the inside simulates the inner wall of the basic body 1. Both layers 1 2a and 1 2b can be of the same material and made as a single piece or of different materials. ~i 2~2~19 :
:~.
As in the first application example the elastic valve element 12 is fastened to mouthpiece 1 by means of a clamp assembly 13. However, in comparison with the - ;
first application example, the second application example as per Fig. 2 has a single-piece valve element cover 13a tip-stretched on the clamp assembly 13 which is iocated above the valve element and has, for the most part, the same shape as the -elastic valve element 12. The valve cover 13a's job is to protect the elastic valve -element 12 against contact and damage. In order to allow the elastic valve element 12 to move during inhalation, the valve cover 13a is bent away from the wall piece of zone 1b of mouthpiece 1 which contains the opening 11. The resulting opening angle can be chosen freely in wide ranges as long as it is insured that the elastic valve element 12 can move sufficiently enough that the opening is opened during exhalation . . ,. :,: ' ,~
Fig. 3 shows a third application example of the mouthpiece as per the invention. Just -like in the first and second application examples, the mouthpiece has three zones 1 a, ;
1 b and 1 c. Zone 1 a serves to secure the mouthpiece on the inhalation therapy device and has a tube-shaped design. Zone 1 b is the transition to the ergonomically shaped - `
zone 1c. An opening 14 in a mainly level wall portion of the mouthpiece 1 is located in ; ` ~;
zone 1 b. An elastic valve platelet 12 is shown in its raised position. When assembled, the elastic valve platelet 12 is located on the mouthpiece 1 in such a manner that a -restraining opening 15l which is located in the elastic valve platelet 12, lies over a restraining opening 16 in the basic body 1 of the mouthpiece. The elasticvalve platelet 12 then covers the opening 14 of the mouthpiece 1 whereby the outer edge of the movable part of the valva platelet 12 lies on the opening 14. ~ -For ~larification, Fig. 4 shows an enlarged view of the part of the mouthpiece marked by reference letter A in Fig. 3. One can see that opening 14 has a circum~erential peripheral step 14a on the lower wall section which protrudes into opening 14 and on which the elastic valve platelet 12 lies during rest and inhalation phases. Due to this design, the dead space in the area of the mouthpiece valve is reduced to the volume defined by the thickness of the edge, marked by reference letter d, and the surface of the opening 14.
.-~
The circumferential peripheral step 14a can have a circumferential sealing lip in the ;
immediate vicinity of the opening 14 which protrudes from the surface of the peripheral step facing the valve platelet; however, the sealing lip is not shown in Fig. 4.
In this case the elastic valve platelet is Iying on the sealing lip.
The elastic valve platelet 12 has a thickness which is not greater that the remaining edge area on which the edge of the elastic valve platelet 12 borders in its resting -~
position. Thus, during rest, the platelet 12 does not protrude out of the surFace of the - ~ `
mouthpiece1.
Clamp assembly 13 is in the form of a bracket which can be designed as a single piece with the basic body 1 of the mouthpiece for restrainment. A hinge allows the -~ , .
2121~19 ,. . .
clamp b~acket to be raised upward as shown in Flg. 3. The valve platelet 12 Is then brought to the assembly position and the clamp brackett 13 is closed. A restraining projection 13b on the side f the clamp bracket toward the valve platelet grips into the restraining openings 15 and 16 in the valve platelet 12 and/or basic body 1. By chosing the dimensions correctly, a sure fixation of the valve platelet is insured which is positioned based on the restraining projection 13b and clamped by the clamp brackett 13b. However, the valve platelet 12 remains flexible in the area of the opening 14 so that air can flow through the opening 14 during exhalation.
A cover 13a on the clamp brackett located above the elastic valve platelet as in the second application example, serves to protect the elastic valve platelet from contact and damages when the clamp brackett 13 clamps the valve platelet 12.
. . .- ,
Claims (10)
1. Mouthpiece for inhalation therapy devices with a basic body (1) with a mainly tube-shaped design, in whose wall there is an opening (14), and a nonreturn valve (11) for sealing the opening (14) during inhalation through the mouthpiece and for exiting air through the opening (14) during exhalation through the mouthpiece, characterized by the fact that the basic body (1) has at least one mainly level wall section in which the opening (14) is located, and the nonreturn valve (11) has a flat, elastic valve element (12), - whose dimensions and shape are adapted to close the opening (14) and - which is fixed to the level wall section in such a manner -- that in its resting position, due to the elastic forces, it lies on the basic body (1) from the outside and closes the opening (14), and -- that it can be partially lifted from the basic body in order to open the opening (14).
2. Mouthpiece for inhalation therapy devices as per Claim 1, characterized by the fact that the basic body (1) has a connection zone (1A) for connecting the mouthpiece to the inhalation therapy device, an ergonomically shaped zone (1 c) for placing in the mouth and a transition zone (1b) for the transition of the shape of the connection zone (1a) to the shape of the ergonomically shaped zone (1c) and that the mainly level wall section where the opening (14) is located is in the transitional zone (1b).
3. Mouthpiece for inhalation therapy devices as per Claim 1 or 2, characterized by the fact that the flat elastic valve element (12) is fastened to the exterior of the basic body (1) by a clamp assembly (13).
4. Mouthpiece for inhalation therapy devices as per Claim 3, characterized by the fact that a single-piece valve element cover (13a), which is located above the elastic valve element (12) on the exterior of the basic body (1) to protect the flat, elastic valve element, is adapted to the clamp assembly (13).
5. Mouthpiece for inhalation therapy devices as per one of the Claims 1 to 4, characterized by the fact that the opening (14) has a circumferential peripheralstep (14a) which extends into the opening (4) and on which the flat, elastic valve element (12) lies on during rest in such a manner that the flat elastic valve element (12) is mainly situated in the opening (14).
6. Mouthpiece for inhalation therapy devices as per Claim 5, characterized by the fact that the peripheral step has a circumferential sealing lip.
7. Mouthpiece for inhalation therapy devices as per one of the Claims 1 to 6, characterized by the fact that the flat, elastic valve element (12) has a restraining opening (15), that the basic body (1) has a restraining opening (16) and that the clamp assembly (13) is hinged and can be flapped from an open position to a position which clamps the valve element and has a restraining projection (13b) that, in the valve-clamping position of the clamp assembly (13), grips into the mutally aligned restraining openings (15, 16) of the valve element.
8. Mouthpiece for inhalation therapy devices as per one of the Claims 1 to 7, characterized by the fact that the flat, elastic valve element (12) has two layers (12a, 12b) of which the first layer (12a) lies on the exterior of the basic body (1) and the second layer (12b), during the rest position of the valve element (12), is positioned on the opening (14) in such a manner that the surface of the second layer (12b) facing the interior of the basic body (1) nearly completely replacesthe inner wall of the basic body (1) in the area of the opening (14).
9. Mouthpiece for inhalation therapy devices as per Claim 8, characterized by the fact that the valve element (12) is single-piece or made of two separate layers (12a, 12b) which are of the same or different materials.
10. Mouthpiece for inhalation therapy devices as per one of the Claims 1 to 9, characterized by the fact that the flat, elastic element (12) is made of a plastic or rubber.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP93108667A EP0626180B1 (en) | 1993-05-28 | 1993-05-28 | Mouthpiece for inhalation therapy apparatus |
| EP93108667.2 | 1993-05-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2124519A1 true CA2124519A1 (en) | 1994-11-29 |
Family
ID=8212950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002124519A Abandoned CA2124519A1 (en) | 1993-05-28 | 1994-05-27 | Mouthpiece for inhalation therapy device |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0626180B1 (en) |
| JP (1) | JP3628350B2 (en) |
| AT (1) | ATE182801T1 (en) |
| CA (1) | CA2124519A1 (en) |
| DE (2) | DE59309723D1 (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5727546A (en) * | 1993-08-18 | 1998-03-17 | Fisons Plc | Powder inhaler with breath flow regulation valve |
| US6176234B1 (en) * | 1997-08-08 | 2001-01-23 | Salter Labs | Mouthpiece for a nebulizer |
| US8397712B2 (en) | 2001-12-21 | 2013-03-19 | Trudell Medical International | Nebulizer apparatus and method |
| US8459252B2 (en) | 2002-05-02 | 2013-06-11 | Pari Innovative Manufacturers, Inc. | Aerosol medication inhalation system |
| US9119930B2 (en) | 2003-10-02 | 2015-09-01 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation therapy device comprising a valve |
| US9700689B2 (en) | 2002-05-21 | 2017-07-11 | Trudell Medical International | Medication delivery apparatus and system and methods for the use and assembly thereof |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5584285A (en) * | 1995-06-07 | 1996-12-17 | Salter Labs | Breathing circuit apparatus for a nebulizer |
| GB9827370D0 (en) | 1998-01-16 | 1999-02-03 | Pari Gmbh | Mouthpiece for inhalation therapy units |
| DE19838711C1 (en) * | 1998-08-26 | 2000-06-21 | Otto Schill Gmbh & Co Kg | Inhaler for atomizing liquids |
| DE19953317C1 (en) * | 1999-11-05 | 2001-02-01 | Pari Gmbh | Aerosol generation unit for inhalation therapies, comprises a valve which allows patient's exhaled air to enter into the surroundings, but prevents direct entry of external air into the mixing chamber during the inhaling phase |
| DE19962110C2 (en) | 1999-12-22 | 2003-06-12 | Pari Gmbh | Inhalation nebulizer with one-piece valve element |
| EP1275412B1 (en) * | 2001-06-27 | 2008-04-16 | Fisher & Paykel Healthcare Limited | Exhalation valve for a nasal breathing mask |
| DE20115203U1 (en) * | 2001-09-14 | 2002-03-07 | Pari Gmbh | Mouthpiece with mouthpiece sleeve for aerosol therapy devices |
| ITPR20020026A1 (en) * | 2002-05-28 | 2003-11-28 | Medel S P A | APPARATUS TO SPRAY A LIQUID, IN PARTICULAR FOR AEROSOL THERAPY. |
| EP2534957B1 (en) | 2007-12-14 | 2015-05-27 | AeroDesigns, Inc | Delivering aerosolizable products |
| FR3014413B1 (en) | 2013-12-05 | 2018-04-20 | Airbus Operations | AIR EJECTION DEVICE COMPRISING AN AERODYNAMIC PROFILE PROVIDED WITH A FLEXIBLE SLOTTED SHUTTER TAB |
| AU2016247911B2 (en) | 2015-04-15 | 2020-06-11 | Philip Morris Products S.A. | Dual resistance dry powder inhaler |
| DE102015211931B4 (en) | 2015-06-26 | 2017-02-09 | Pari Gmbh | Mouthpiece for an inhaler |
| US10907674B1 (en) | 2016-05-16 | 2021-02-02 | Trudell Medical International | Elastomeric component and apparatus and method for assembly thereof |
| EP3441098B1 (en) * | 2017-08-08 | 2020-09-30 | Air Liquide Medical Systems S.r.l. | Nebulizer for aerosoltherapy made of sub-units detachably secured together |
| EP3441097B1 (en) * | 2017-08-08 | 2020-09-30 | Air Liquide Medical Systems S.r.l. | Nebulizer for aerosolizing a liquid with a detachable cover including a valve system |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE483069C (en) * | 1927-08-13 | 1929-09-25 | Draegerwerk Ag | Check valve for respiratory equipment |
| BE483136A (en) | 1947-09-04 | 1942-06-30 | ||
| DE2941132A1 (en) * | 1979-10-10 | 1981-04-23 | Loibl, Dr. med., Helmut, 8170 Bad Tölz | Inhalation device with inclined outlet - having rim along lower edge to collect droplets and allowing normal posture for patient |
| US4580604A (en) * | 1983-06-23 | 1986-04-08 | Mitsubishi Denki Kabushiki Kaisha | Discharging valve device for a compressor |
| WO1986001731A1 (en) * | 1984-09-18 | 1986-03-27 | Vortran Corporation | All purpose nebulizer |
| EP0266456A1 (en) * | 1986-11-06 | 1988-05-11 | Moldex-Metric AG & Co.KG | Respiratory face mask |
| ATE72997T1 (en) * | 1987-03-10 | 1992-03-15 | Brugger Stephan | AEROSOL ATOMIZERS. |
| DE3901963C1 (en) * | 1989-01-24 | 1990-08-09 | Joachim Dr. 5216 Niederkassel De Schatz | Inhalation device |
| DD284810A5 (en) * | 1989-06-14 | 1990-11-28 | Veb Transformatoren- Und Roentgenwerk "Hermann Matern",Dd | UNIT AND OUTDOOR UNIT FOR AN AEROSOLGERAET |
-
1993
- 1993-05-28 DE DE59309723T patent/DE59309723D1/en not_active Expired - Lifetime
- 1993-05-28 AT AT93108667T patent/ATE182801T1/en not_active IP Right Cessation
- 1993-05-28 EP EP93108667A patent/EP0626180B1/en not_active Expired - Lifetime
- 1993-05-28 DE DE9321308U patent/DE9321308U1/en not_active Expired - Lifetime
-
1994
- 1994-05-27 CA CA002124519A patent/CA2124519A1/en not_active Abandoned
- 1994-05-30 JP JP13943694A patent/JP3628350B2/en not_active Expired - Lifetime
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5727546A (en) * | 1993-08-18 | 1998-03-17 | Fisons Plc | Powder inhaler with breath flow regulation valve |
| US6109261A (en) * | 1993-08-18 | 2000-08-29 | Fisons Plc | Powder inhaler with breath flow regulation valve |
| US6176234B1 (en) * | 1997-08-08 | 2001-01-23 | Salter Labs | Mouthpiece for a nebulizer |
| US8397712B2 (en) | 2001-12-21 | 2013-03-19 | Trudell Medical International | Nebulizer apparatus and method |
| US8844520B2 (en) | 2001-12-21 | 2014-09-30 | Trudell Medical International | Nebulizer apparatus and method |
| US8459252B2 (en) | 2002-05-02 | 2013-06-11 | Pari Innovative Manufacturers, Inc. | Aerosol medication inhalation system |
| US8973571B1 (en) | 2002-05-02 | 2015-03-10 | Pre Holding, Inc. | Aerosol medication inhalation system |
| US9308335B2 (en) | 2002-05-02 | 2016-04-12 | Pre Holding, Inc. | Aerosol medication inhalation system |
| US9700689B2 (en) | 2002-05-21 | 2017-07-11 | Trudell Medical International | Medication delivery apparatus and system and methods for the use and assembly thereof |
| US9814849B2 (en) | 2002-05-21 | 2017-11-14 | Trudell Medical International | Medication delivery apparatus and system and methods for the use and assembly thereof |
| US10881816B2 (en) | 2002-05-21 | 2021-01-05 | Trudell Medical International | Medication delivery apparatus and system and methods for the use and assembly thereof |
| US9119930B2 (en) | 2003-10-02 | 2015-09-01 | Pari GmbH Spezialisten für effektive Inhalation | Inhalation therapy device comprising a valve |
Also Published As
| Publication number | Publication date |
|---|---|
| DE9321308U1 (en) | 1997-02-13 |
| ATE182801T1 (en) | 1999-08-15 |
| JPH07185003A (en) | 1995-07-25 |
| EP0626180B1 (en) | 1999-08-04 |
| EP0626180A1 (en) | 1994-11-30 |
| JP3628350B2 (en) | 2005-03-09 |
| DE59309723D1 (en) | 1999-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |