CA2128335A1 - Adaptor for drug delivery - Google Patents
Adaptor for drug deliveryInfo
- Publication number
- CA2128335A1 CA2128335A1 CA 2128335 CA2128335A CA2128335A1 CA 2128335 A1 CA2128335 A1 CA 2128335A1 CA 2128335 CA2128335 CA 2128335 CA 2128335 A CA2128335 A CA 2128335A CA 2128335 A1 CA2128335 A1 CA 2128335A1
- Authority
- CA
- Canada
- Prior art keywords
- upper section
- section
- vial
- fluid
- cartridge
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2096—Combination of a vial and a syringe for transferring or mixing their contents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/1407—Infusion of two or more substances
- A61M5/1409—Infusion of two or more substances in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
- A61J1/10—Bag-type containers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/1475—Inlet or outlet ports
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/201—Piercing means having one piercing end
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
- A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
- A61J1/2006—Piercing means
- A61J1/2013—Piercing means having two piercing ends
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/281—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
- A61M5/282—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by compression of deformable ampoule or carpule wall
Abstract
A drug delivery device (10) is provided for coupling a first container (54) including a beneficial agent to a second member (64).
In an embodiment, the device (10) includes a substantially hollow member (12) having a cannula (26) mounted within a wall (14) that divides the substantially hollow member (12) into a first and second section (16, 18). The first section (16) includes means forreceiving at least a portion of a first container (54). The substantially hollow member (12) includes a wall (60) that defines an exterior of the first section (16) that is substantially flexible. A number of different cannula and flow path structures within the hollow member (12) are possible pursuant to the present invention.
In an embodiment, the device (10) includes a substantially hollow member (12) having a cannula (26) mounted within a wall (14) that divides the substantially hollow member (12) into a first and second section (16, 18). The first section (16) includes means forreceiving at least a portion of a first container (54). The substantially hollow member (12) includes a wall (60) that defines an exterior of the first section (16) that is substantially flexible. A number of different cannula and flow path structures within the hollow member (12) are possible pursuant to the present invention.
Description
~ WO94/110~6 2 1 2 ~ 3 3 P~T~USg3J0939~
i ~ P ~ c I F I C _T O ~
AD~TO~ ~OR D~G D~ Y
ACKGROUND 0 ~ ~ Q~
S The present inven~ion relates general~y to the delivery of a beneficial:agen~ to a patient or in~o a system fsr later delivery to a patient. .,. More specifical~y, the present invention relates to an improved~drug delivery system.
For many applications, drugs can be mixed with a diluent before being delivered, ~or example, ; intravenou~ly~to~ a patient. The diluant can be, for example, a dextrose solution, a saline solu~ion, or even watex.~ To~thi~ ~nd, many drugs are suppli~d in powdered 15 ~ form and~packaged in:ylass vials~ Other drugs, such as ome:~chemotherapy dru~s, are~pa kaged i~ glass vials in : a~iquid~s~ate~
: Powd~red~rug ~can be recons~itu~d by u~ilizing a syrinqe~ Q~inje~t~ uid into~a via1:~ fsr~mix m ~; the 20 ~ syringe ~Ye~tually withdrawing ~t~e ~ixed~ soluti~n from he~vial.~ hQn~a drug mu~t::be~dilut~d be~ore delivery to-a~p~ti0nt,~the~drug is often injeot~d into~a container of~:diluen~ a~ter it is~reconstl~uted~ a container can be connected~to~an~administration~ t fo~ del~very ~o ~he 25~: pa~ent.~
Drugs~may be paokaged separa~e ~r ~ the dilu~nt ~or vari~ous:;rea~ons. One of the ~mo~t important reas~ns is that many ~d~ugs~do n~t retai~their~hemical:and`physical : :stability~when~mixed with a diluent and ~thus cannot be ~ s~ored for any: substantial period o;f ti~e. Also, drugs are oftsn :packag~d separately from thP diluent be:cause : : ;: many companies that manufacture drugs are~no~ engage~ in ~ : ~
~ , ~ :
.
WO 94/110~6 P~/US93/~9394 2128~3~ - 2 -the business of prvviding medical ~luids and con~airlers for intravenous delivery, and vice versa.
Therefore, doctors, nurses, pharmacists, or other medical personnel must mix the drug anc~ diluent. This presents a number of problems. The rec:on~titution pxocedur~3 is time consuming ancl re~uires aseptic techniqtaes. The operator must pro~ide the proper à~îue~t and a syrislge b~ore b~3ginning. The reconstitution procdure should be perfonned preferably or under pre~erably sterile conditions. This re~irement requires the opera~or~:tc~ be more cau~ious, thereby c::onsuming more ~ime. ~dditionally, terile ~ondit.iorls are o~en hard to ~aintain. In some instances, a lamin~r ~low hood may be required :under w~ich the: recorlstitution proc:~dure is 15 ~ perf orm~d r ~ ~
A furth~r~ concern is that so~ drugs, such as chemoth~r~py ~ ~rugs, are ~ toxic Expo~;ur~ OI the operator to l~he ~drug during res:on ti~u~ion can be dangerous, ~ ~ p~cially~ he operator~ works ~with such drug~ on a 0~ slaily ba~is ~and~ is ~ repeatedly expos d to them.
lthough a~ter a drug is ~con~ti~uted arld withdrawn into ~ ~yrins~ barrel, the~ drug can, ~n sQme instanc:es, be: inje~ ed ~ oediately into a pa~ient,~ more typi6~ally, howev~r~ ~he:~reconstituted drug is injee~ed from the yringe in~ o ~ la~:ger conkainer of solutic~n for connectiorl to an in~ravenou~ adminis~ration set.' A
larger contai~er of solutio~ may be necessary because oft~n the ~reconstituted drug in the syringe is at su ::h a conc:entration as to ~ause ~local toxici~y in the vein~
30 : of a patient~ near the injecl:ion site where the needle pierc~s khe skin:O This can crèate severe vein irritatio~
: which can be harmful .
WO g4tl 1056 PCr/US93/09394 212~33~
Addi l:ionally, even though th~ proper dos~ of medic:ation may be in the syringe, immediate in; ection into the patient ' s blood stream can create a condition of systemic: toxicity wherein the level oiE drug concentration in the patient ' s entire blood system is dangerously high. Yet anc~ther reason for not making an inj ection f rom the syringe directly into the patient is that such an injection creates an additional injectic)n ~ite into the patient; this can be painful for the 9 0 patient and provides another opportunity ~or infection.
For these reasons, the reconst~ tuted drug is more : ~ typically injected into a diluent ::o~stainer.
A number of drug: delivery syst~ms are known.
: In one delivery sy~tem that is curr~ntly used, a 15 : drug containe~ ~ in a ~ vial in a solid state is ~; ~ reoon~titutéd~ witb :: a: predetermined Yolume of di~uent :; usin~ a nêedle and syringe. The vial csntaining he drug and:~ soltation~ ~i5~; then mated :~onto zLn :intravenous a~ inistrat~ion~ se~. The :drug is~delivered to a patierlt 2 0 as diluent`~flows through ~he vial to the patient ~arrying rith ~ ~it~ thé ~ dic~olved d~g . ~ ~ ~
ano~her~:IV drug deli~ery ~sy~te~s, the drug olutiQ~ is~ packaged in ~lexible plas~ic cont iners.
So~e;drugs~packaged:in this manner may:be stored at room : 25 temper~u~e~and the drug is deliver~d by ~onnecting ~he container ~to an intravenous ~dminisl:rat~on s~t. ! Some dru~s paclcaged in this manner may be stored in a ~rozen sta~te in: order~ to: improve drug sta~llity. In th~se cases, the ~ drug ~olution must ~ be: thawed and then 3~0 ~ connected ~ ~ o an :intravenous adminis~ra~ion set for deliv@ry to~ the patient.
Another system requires drugs to be con1:ained in a special ~vial. An ac~ivated vial is then raal:ed to a ::
, . ~ .. . , ,, . = . . . . .. ... , . . .. . ~ . ~ z WO94/11056 PCT/US93/~939~
2 12833~3 4 _ special container. The vial stopper is re~oYed and ~he drug is ~rans~erred to th~ container by flushing the vial with the diluent in the container. The d~ug is delivered by connecting the container with the dissolved drug to an intra~enous ad~inistration set.
Drugs can also be delivered intravenously via a syringe pump. Briefly, a dose of reconstitute~ drug solution ~s withdrawn by a sy~ing~. The drug solution in the syri~ge is then re~rigexated or frozen until u5e.
The drug solution is brought to room emperature a~d infused into a patient via a syringe pump.
There are some disadvantages with some o~ th~ above systems and~procedures. On of the di~advantag~s is drug ~: waste. ~ Due to chemical and physical instability, once 1~ ~ a:soIid dru~ is;reconstituted with diluent tor a ~rozen formulation~ is thawed~ it cannot be ~tored for any ubstantial~amount of: tim~ Therefor~, if the drug s:olut~on~is:~not~ administered ~o the patient within a given period of~time, the drug~:~must be discard~d. Drug ~waste can;~be a ~ve~y costly expeno~ to a hospital p~ar~acy.~
S~me~:~of the current pro~e~ure~ ~or intravgnous administrat;i~on~are labor intenæive. As pr~viously noted, recon~titution of a drug wi~h a needle and syringe is time consuming and~re~uir~s an aseptic snvironment.
Li~ewise, e~posure o~ the opèra~or to the drug may b angerous~, especially if the operator works with the drug on a daily basis. Of course:,:need~e sticks may expose : healthcare~ professionals to hazardous di~eases and ~ 30 ~ infection~
::;: A further disadvantage of some of the above procedures~i~ that they require a s~condary IV
:: : :
.
W~ 94/1 ~056 PCr/U593/0939 _ 5 ?1283 :
administration set for delivery of the drug. The secondary set can be cumbersome f or both the patient and the clinicianO Elimination of the secondary set (,along with the n~edle and syringe) may also reduce solid waste and disposal costs.
.'. U.S. Pat~nt No. 4,850,978 disclo~es a dru~ delivery system for delivering drugs to patients and/or recons~itution of a drug. The system inclu~es a cartridgç for introduclng a beneficial agent into a fluid . 10 conduit for delivery of the agen~ to a patient. The cartridge includes a ri~id hollow tube and an agent containing chamber slidably mounted at least partially within the hollow tube . In a f irst, pre-use position, : ~ khe ch~mber extends farther from the hollow tube th~n it ,~
i;15 does in a second position. A cannula is mounted ts the ~i bol 1 ow tub~ extending oppos ite the chamk~er . When the c ~ chaI~Iber is in tbe second positic: n, the cannula pierc:as the closu~e msans~ creatirlg a 10w path.
U.S. Patent~ No. 4, 804, 366 also discloses a c~rug 20 delivery system including an adapter ~having an improved 9! ~ flow path ~e4ns providing bo~h an inlet and an outlet ~o the agent containing chamber of a cartridge. The ; ~ ~:; cartridg~: an~ adapt~r~ permit a ~single opening through the injection sites~at:opposite ends of the flow path means, : 25 : while still~ permitting simultaneo~ flow both into and out of ~e char~ber.~ An adapter and a cartridge is pro~,rided, including a rigid c:annula with an inlet and an outl t: and ~ the: shell substantially coaxial with and spac~d rom the c:aImula intermediate o:E the annula inlet 3 0 and tha canr~ula outle~ so tha~ ~he hell of the cannula defines a channel :ther~between. Both the camlula inlet and the canmlla outlet are ad~ptable to ~Eorm a single :: :
W094~1l056 PCT/~S~3J093 ;
. ?i 21283~
piercing opening in a resi1i~nt injection site associa~ed with the cartridgeO
.SUMM~RY OF ~HE INV~ION
~he present invention provides an improved drug de1iv~ry systemO The sy~tem faci1itates the reconstitution and i~trav~no~s administration of a beneficial agent. Generally, pursuant to the present invention, an adaptor is provided that provides a site for connection to an in-line IV et, a site for connection to a via1 containing a bene~icia1 agent, and ~he adaptor includes at 1eaet an upper section for cont~ining a volume of diluent, the upper sectio~
including portions thereof that can be biased inward1y;
: ~ in a preferred embodiment, the portions that can be ~iased inwardly are f1exib1e walls. A cannu1a can be : mounted within:the adaptor. To this end, a deYice ~is pro~id~d for coupling a irst container~inc1uding a benefi:cial agent ~o a ~econd member.:~ In;~ an ~embodiment, the ~device includes a ~substantia;lly;hollow member havin~a spike moun~ed within a;wa1l~that divid~s the substantia11y hollow me~ ~r into a irst and~second se:ction~ ~he s~cond ~ection inc1udes mean~ for;;:~receiving at least a ~ortîon of ~ fir t con~ainer.~ The~sùbstantia1ly~ho110w:member inc1udes a wall that defines an exterior of the ~irst section that is:subs~ntially flexi~le. In an embodiment,~ the h~110w mem~er~has a~ ube like shape.
A num~r of differe~t cannu~a and f10w path : &tructures~within~the ho1low member:are possible pur uant to the pre~ent in~ention. In an embodiment, a shell circum-cri~bes~ a portion of the cannu1a and defines a ~; : channel~having an inlet and an out1et. The shell and cannula can extend for the same distance into the ~pper : : :
::
.
WO 9~/1 10~6 PC~I`/US93/0939~
212~33~
section or the shell and cannula can extend a~t different distances ir~to the upper section. In an embodiment, the device includes two c:allnulas locat~d thereirl.
For use with an in-line IV set, the presen~
S invelltion also provides a cartridge for introducing a bene~icial ag~nt into a fluid conduit or delivery of the benef icial agent. In an embodiment, the cartrid~e includes a hollow tube having a cannula mounted therein def ining a channel having an inlet and an outlet . A
shell circumscribes a portion of the hollow tube and def ines a c:hannel also having a~l inlet and an outlet .
~he hollow tube includes a wall member dividing the hollow tu~e into ~n upp~r sectior~ ancl le~wer section, the ~:hannels of~ ~he cannula and sh~ll passing through the ` 15 wall. The upper section is ~;o cons~ruc~d and arranged to reGeiye at least a portion of the vial including a benefic:ial agellt. The upper ses:tion î~ defin~d, at least in p~rt, `by ~;ubstantially flexible walls.
Prefer~bly, the upper section is di~vîd~d înto a ~0: sec~îon for~ :housîng a diluent and a ~op portîon ~or rec~îving a por~ion of a vial.
Preferably~ the hollow: me~er incIudes mQans for pî~rcing a closure of the: vîal when the Yîal îs received by the upper ~;ection.
~:: 25 A ~thod of delîv~rîng a drug i also provîded. The ~ethod c:ompri~es the steps of- providi~g an ~daptor încluding an upper section havin~ ~t lea~;t par~ially f le~xîble walls and a cannu}a provîding f }uîd : ~ :
colomunîcakion between the upper ~ection and an outlet of : ~ : 30 the c:annula; proYidîng the upp~r sec~ion with a diluent:
couplîng a vial ~of beneficîal ag~ant to ~he upper ~e tîon.
and e~tablîshing ~luîd communicatîon be~ween an interior c)f the vîal and the upper section; causing fluid to flow .
WO 94/1 105~ PCr/US93/0~394 . .
.~ .
212833~
into the vial by, at least in part, squeezing at least a portion o~ the walls of the upper s~ction; allowing a resultant product to f low f rom the vial into th~ upper section: and causing the resul~ant produc~ to flow through the outlet of the cannula.
- ~ue to the flexible walls that defin~ the first sec:tion, diluent c:an be easily added to the vial. . This allows the drug contain~d within the vial to be re::onstituted and/or mixed with the diluent in the vial.
The resultant product can then be tran~erred back to ~he adaptor .
By utilizing different cons~ructions of the adaptor, including the cannula and shell arrangement loeated therein, drug delivery pro~iles can b~ modif ied . This allows a v~riety of drugs ~o be delivered utilizirlg the ' adaptor.:
An advantage of the present invention is that it provid~s an adaptor that llows an in-line IV s~t to be u ed ~with any off-the-shel~ dnlg vial.
P. fu~h~r ad~antage of the pre~ent invention is that J ~ ~ it could short:en product developmental tiDle5 ~ince all : drugs cQntained in their respective manu~acturer's vials have es~ablished ~xpiration.
Moreo~rer~,~ an advantage of the present invention is ~: 25 that it :r~duces pharmacist's time and the additional expe~se~ with respect to the use uf needle~ and syringes.
And further, an advantage of the present invention is th~t the :adaptor is user fri~ndly, for examp~e, a nurse can activate and re~onstitute the drug in a sqngle 31) 5't~p still further, an ad~antage of the present inv ntion is that it reduces waste, the activation~reconstitution i:
.
WC~ ~4/1 1~56 PCI/US93/09394 212~33 procedure can ~e done immediately . pFior to administration .
An advan~age of the presen~ invention is that it does not re~uire a specially designed vial and accor~lingly, it eliminates the cost ~r putting drugs into specially designed trials.
Additiosl211y, an advantage of the present invention is that it reduces waste in t::ontrast to some sy~tems wherein once the spe~ially designed vial is placed into an on-l ine IV system, it must be used; because the adaptor of the present invention is not activated until immediately prior to administrationt this greatly reduces the potential for drug waste.
~: Furthennore t an advantage of the present invention i5 tha~ a lpiggy baclc is not re~ired.
A~other adYantage of the pre~ent inven~ion is tha~
the adap*or c:æl allow~ the delivery o drugs in volumes as low as; a~ bolus inj~c~ior~ with :a~syringe or in volum~s and conc~ntrations similar to intraverlous drip infusion.
: Additional features ~nd advantages of the preserlt invention ar~ describèd: in, and will be appar~n~ from~
: the detailed: descript~on of the presently pr~ferred embodiments: and from~the dra~ins~s~.
2 5 Figure 1 illu .trates a perspecki~e ~iew of an emhodim~nt! of the ~adàptor of the pxesert inventi~sn.
: ~: Figure: 2 illustrates an ~mbodi~ent OI the adaptor of the pr~sent invention wher~in a vial has ~een mated to the adaptor.
Fi~ur~ 3 illusl:rates a persp~ctiv~ ~iew of the adaptor and Yial arrangement o~ Figure 2 wh rein diluent from the adaptor has }: een aslded to the ~ial .
, :
.
WO94/11056 PCT/U~3~09394 212833~
Figure 4 illustrates the vial a~d adaptor arra~gem~nt oX Figure 2 mated to an infusicn ~Q~.
Figure 5 illustrates an embodiment of the adaptvr of the present invention.
Figure fi illus~rates an enlarged perspective view of the flow paths of the embodimen~ of Figure S with parts broken away.
Figure 7 illustrates a furth~r embodiment of the adaptor of the present invention.
Fiqure 8 illu~tra~es a cross-seGtional view of the cannu}a of the adaptor of Figure 7 taken along lines VIII-VIII. ~ :
~: Figure 9 illustrates still a further embodiment of he adaptor of the present inv~ntion.
Figures 10-l2~illustr~te perspe~tive views of an ~: ~ embodim~nt o~th2 present inventi~on illus~rating a m~thod for filling~the~ adaptor with a diluent.
:DETAILED DESCRIPTION~ ~
~: 20 The~pr~s~nt i~vention pr w ides ad~ptoxs~:for coupling a ~i~l containing :a benefi~ia1~ag~nt tQ an~ in-line IV
s~ dditionally,: the present~ invention provides improYe~ ~ethod~:for admini tering a:~drug: to a patient~
As ~ set~ ~or~h ~ in detail hereinafter, due to the construc~ion of the a~aptor sf the present invention, it : can b~ utilized with most any in~ra~nbus drug. Tb thls nd~,~the adaptor~can be modified~to~proYide d~ug delivery profiles a~llowing the administration~ oX many ~aried : drugs.
Referring now to Figure l, an embodim@nt of the daptor l0 ~is illustrated. As illustrat~d, the adaptor 10 preferably comprises a substantially tubular shaped cartridge 12 that is divided by a wall l4 into an upper ~0g4~ P~/U~93/09394 212~33~
section 16 and a lower section 18. The lower section 18 comprising a substantially rigid m~mber having a key wall 20. The wall 14 is mounted across the cartridge 12 and defines the starting point for the key wall 20.
In the preferred embodiment illustrated, a cannula 26 extends through the wall 14. The cannula 26 defines a channel 27. Additionally, a generally cylin~rical shell 28 extends from both sides of ~he wall 14.
The shell 28 is spaced from th~ cannula 26 with the shéll, in the embodiment illustrated in Figure 1, encompassing *he cannula but being shorter at either end of the cannula. The cannula 26 includes an inlet and an outlet 30 and 32:, respectively~ Pr~fer~bly, the inlet ~ and the outlet 30 and 32 of the cannula 26 are blunt.
:~: 15 ~ Of cour.e, i~ desiredl either or both of these members could be point~d. ~ :
The ~s:hell 28 is:interm~diate of the cannula inlet and outl~t~30 and 32. The cannula 26 and~ ~heIl 28 defin~
a second chann~l 34 therebetween. In a preferred : 20 ::~embodiment, ~the periphery of the cannula 26 is circular : ~ along its~ien ~ h. Similarly, ~h~ internal surface of the shell 2~ is~ preferably arcuate ~an~ preferabIy circular : :along its;~length.~ ~
he second~ch~nnel 34 inc}udes a channel inlet 36 : 25 d@fined between the shell 28~and ~he cannula 26, short ~: o~the cannulajoutlet 32. Slmilarly, the seGond ~hann;el :~ : : includes a channel outlet 38 defined by tha shell 28 and ~ ithe cannul~ , short of the c~nnula inlet 30.
;~ ~ : : The cannula 26 is secured to the ~ 8 while ` 30 ~ still maintaining an open flow path through the channel : inlet 36, the channel 34, and the ch~nnel outle~ 38 : Thu ~ a v~ry small flow path is created ~utside a single cannula with precision.
.
~094/1l056 PCT/~S53/09394 ~12833~
The upper s ction 16 of the cartridge 12 is de~iqned to preferably receive a diluent. To this ~nd, in the preferred embodiment illustrated, the upper section 1 i~cludes a first and second section 40 and 42, respectively. As illustrated in Figur~ 2, the first section 40 is designed to house the diluent 43.
In order to prevent the diluent rom flowing from the first æection 40 out through the channels 27 and 34, as illustrated in Figure } a sheath 44 is provided for covering ~he end of the cannula and shell 28.
Preferably, ~th~ sheath 44 is substantially similar to ; that dîsclosed in U.S. patent application Serlal NoO
:~ 07/573,529 :en itled: 'IS~EATH ~OR C~NNUL~", the ;~ disclosure af whîch îs încorporated herein by ref~rence.
As set forth in::that pate~t application, the sheath 44 provides~a water tight s2al th~r~by preventing any of the dilu~nt ~rom leakin~ out of either o~ the channels defined~by~the:~cannula 26 or shell 28.
owever~, the sheath:44 i~ o so constructed and arran~ed ~hat~aven when us d wi~h a blunt:@nd~d cannula 26, ~he:sh~ath~will rip, n~ot core, upon the xertion o~
: ~ s~ficient:~orce by the blunt end of the cann~la again~t the~walls:46. This allows~the blunt ~nd of the : cannula:26 ~to be receîv~d withîn an injec~ion sîte without ~irst havin~ to manually remove the sheath 44.
The sheath 44 will fold back ~lo~g the cannula 26 and the sh~11 28~:in~:an s~cordion~fashion. This will allow ~he : : blun~ end of th~ cannula:2~ and shell ~8 to enter the .
in3ection site, but preYent the sheath 44 ~rom enterîng the injection site.
: Due to the use of the ~heath; the entîre first se tion 40 of the adaptor 12 can be ~illed with diluent îf desired. Addîtionally, if desired, a remo~able cover :
W0~4/1105~,fi PCT/USg3/09394 212833~
- 13 ~
i ,, 47 can be provided to protect the sheath 44 prior to use ~ of the cartridge.
i To divide the upper s~ction 16 into ~irst and second ; sertions 40, and 42" 2 wall 48 is pro~ided. Preferably, , 5 the wall 48 includes means for piercing a vial. In ~he J, - preferr~d ~mbodiment illustrated, ~he wall 58 includ~eis a spike 50 that provides fluid com~,unication be~we~n the :, first and second sections 40 and 42. The wall 48 ,~ pr~vents diluent hous2d in the adaptor lO from l~,,aking out of a top of the first section 40 of the ad,aptor lO.
The spike 50 provides maans f'or pro,viding fluid ~4 communic~ion between the first section~,0 of the adaptor 1 : }0 and a vial 54 to be ~nrketed on ~he second section 42 :
of th~ adap~or.: Of course, any pierring means that ~5 allows ~luid flow betw~en the vial 54 and th~,~ adaptor lO
c~n be used. As illustrated, pre~'erably, the spike 50 includes a~foil seal 56 to preYent le~kag~ of the diluent prior to docking;with a vial 54,. Additionally/ to insure the-steri1ity of the spike 50, a removable co~er 58 can ~e~proYided.~
In~the preferr~d ~mbodiime~t illustr,~ted,) th~e spike , 50~is:located~so as to be recessed from a plane deifined by~an~:open~end of~the second ser~tion 42. 8ecause the spike ~SO;~is~;recesse~, this ac~s ~o reduce accidental ~l~sti~kæ~ of personn~Pl hahdling the adaptQr lO as well as : pre~ent t ~ ~h çontamination. . ~ .
.j : If de5~ired, the second section 42 can i~clude on an interior surface bumps (not shown3 having a sloped side facing the open end of the second section~ Such a . -structure assists in s~curing a vial 54 to the adaptor ~: ~ 10. ~n example of such a structure i5 set f orth in PCT
~`~ ; PU~lishQd Application No. W091/11152, the disclo~ure of : which is hereby incorporated herein by reference.
.
..~. , wo 94/1 10S6 Pcr/US93/0939~
....
~12333~ - 14 -As illustrated in Figure 2, in USB , a vial 54 is mates:l with the adaptor 10. To this ~nd, at l~ast the top portion 56 of the vial 54 is received in the sec:ond sectîon 42 of the adaptor 10. This causes the spike 50 to pierce a rubber stopper 5~ of the vial 54, establishing fluid communication be~ween tl:~e cartridge 12 and the vial S4. Due to the construction of the cartridge 12, the c:artridge carl mate with any standard off the-shelf vial 5~ containing a beneficial agen~.
Pursuant to the presen~ invention, at least a po~tion of the walls 60 that define the first section 40 can be biased inwardly, as illustrated iI~ phantom lines in Figure 1. Pre~rably, at least a portisn o~ the wall~
60 are construct~d from a flexible materi~l. The : :
:: 15 material, however, should ~e su~fi~iently rigid to pro~ide stabil:ity to~ tlle adapt:ar l~, but allow the walls 60 to be biased inwardO In a pre:f~rred ~bodiment, the erltire walls 60;are flexib.le. Collv~rsely, the walls 61 that: define ~the upper :section 40/ :i~ d~sir~d, can be 2 0 rigid .
s illustrated~in Figure 3, in order to reconstitute or dilu1:~ a ~drug: 65: coDtain~d in ~he ~rial 54, the adaptor l0 i~ turned~ upside dowr~ iluent 43 contained in the ad ptor lO~ is ~then forces~ into the vi~l 54 by squee~ing :: 25 th~ ~lexible walls 60` of the adaptor. This forces the diluent 62 fro~n the adaptor lO in~o th~ in~erior of ~he mated druq vial~ 54.
: Th~ drug 65 contained within the vial 5~ is thPn allow~d :to~ dissolve andjor mix with the diluent. The : ~ ~ 30 resultal-t drug solution is then transferred back into the adaptor lO by holding the adaptor in an upri~ht position such that the solution is at the topp~r end of the vial 54 . The adaptor lO is then co~pres~ed f orcing air into .
. WO94/11os6 PCT~US93/0~394 2~3~; -the vial 54. The higher pressure in the vial 54 then~orces the liquid from the vial into the adaptor 10.
Referring now to Figure 4, the adaptor 10 can ~hen connected to an IV administration set, for example, the Mainstream~ administration set aYailable from ~axter Healthcare of Deerfield, Illinois. The drug that was contained in the ~ial 54 can now be deliv~red to the patient. To accomplish this, the adaptor lO is docketed on a receptacle 64. The recept~cl~ 64 includ s upper and Iower fitments 66 and 68. The upper ~i~ment 66 includes an inlet 79. The lower fitm~nt 68 includes the outlet 72. A pierceabl~ resealable injection site 73 i~ mounted within the upper fitme~t 66 of the receptacle 64. An example of:such an IV administratio~ set is disclosed in UOS. Patent No~ 4~,804,366, the ~iscl~ ur~ o~ which i5 : inco ~ oEated h~rein by~refer~na~. ~
The reo~ptacle 64 in~ludes a re~ nt divider 74 trapped betwe~n th~:upper and lower ~ nts 66 and 6B
of the receptacle:~64. T~e resilient~divlder 74 defines a~ narrQw~thr~ugh: bore 75 dix~ctly~below the resilient pierceable~;injection sit~ 70. B~or~ ~he: cartridg~ 10 o~f the~pre ent~i m ention is engaged wi h~the receptacle 64, fluid~lowing~rom a par~nteral container 76 flows through the~fluid conduit 78 and through a receptacle inlet 79 whereon it flows into the xeceptacl~ above the . dividin~ ~plate 74, ~through the:~ through bore 75 and down6~ream~0 the rec~p~acle outlet 72. Fluid then flows downstream:to the~ patient7 As illu~trated in Figure 4,`when the cartridge 12 30~ is mount~d~ sn the receptacle 64 the cannula ~6 and the shell 28 ~pierce the resilient in~eck~on site 70. The cartridge:l2 continues to b~ urged do~nwardly so that the cannula outlet 30 enters the thro~gh bore 75 and is .
WO ~/~0~6 PCT/~Sg3/0~394 212833~ ~ 16 -i li~uid-æ~alingly engaged by ~he resilient divider 74 around the periphery o~ the cannula outlet 32.
Upon engag~ment of the cartridge 10 and receptacle 6~, as illustrated in Figure 4, liquid flowing into the receptacle at the inlet 79 is prev~nted ~rom passing through the through bore 75 and the receptacle because the resilient divider 74 has been seal~d abou~ the cannula outlet 32 portion at the through bore 7~. Thus, 1 iquid ent~ring the receptacle enters the channel inlet 36, flows through the channel 34, and enters the ~irst section 40 at the ch nnel outlet 38.
In an e~bodiment, as liquid risas wi~hin t~e first , : section 4Q, it will continue to rise until it reaches the ~ ~ cannula inlet 30, whereupon liquid begins to exit the i~ 15 chamber thrQugh the cannul a 26 downst~eam through the ~ cannula outlet 32. ~i ~ id exiting the cannula 26 has an 3~ appropriate concentration for th~ beneficial agent mixed therewith f:or deliv~ry to the patient. In the ~:: illustra~ted embo~iment, ~he upward liqu d flow path ~; 20 created within~the first section 40 by the ~hell 28, cha~nnel 34, and~ cannula 26 crea~e~ a densi~y gradient within the fir~t ~ction:4:0 such that the conc~ntra~ion .~ of drug wi~hin the liquid exiting at the cannula outlet . ~
32 will not be so high as to create local toxicity of the patien~.
A5 illustrated in the Figures, many e~bodiments af the adaptor 12 are possible. The drug delivery to the patient mus~ m~et clinical guidelines. For IV therapy, these guidelines may include parameters -~uch as delivery rate, deli~ery volume, and delivery concentration.
Typically, the clinical guidelines for drug delivery sp~cify a range in which the drug delivery parameters : should lie. Drug delive~y rates, concentrations, ~nd ,, .
W(:~ 9~/110~6 Pcr/us93/o~3g4 212833~
volumes can be controlled by modification of the adaptor 10 .
The geometry o~ the adaptor lO, diluent f~ow path, drug solution den ity, and drug solution volum~ all can be tailored to yield a desired drug deliv~ry pro~ile for a particular drug. ~ Adaptor lO design modi~ic~tions can yie1d drug del ivery r~tes which range f rom bol.~s IV
inj action to IV drip infusion .
The den~ity of the drug solutic: n relative ~o that O:e the diluent has a major impact on the rate o~ drug delivery from the ~ adaptor lO. ~or a given adap~or design, the r 1ative d~nsity of the diluexlt and drug solution determîne the mixing c:haracteris~ics in the adaptor lO during delivery to the administratîon set.
~ The adaptor ;10 may ~ be desiyned~ so that by varying only : ~ th~ rela~i~re ~density of ~he drug solution and diluent, he ;de1iv~ rate:~froxn~ the adaptor; can ;range ~rom ~olus IV to i~je~tion~to IV~drip in~usi~n.~
rug `~ deliver~ rates, ~rolNmes tvolume r~quired to ~ deli~r~the;~dose), arld concentration~s are func:~ions of h~ vo1ume~of~so1ut:ion~:in the adaptor l0.~ Therefvxe, by : ao~trollin~ h~ olution:Yolume in:tha adaptor lO drug de~livery ~o:~the~pa~i~nt can:b@ ~overned.
Thé::drug:~:de1~ivery:rate,~o1ume, a~d~maximum ef~luent ~ :con~ntration ~from ~a "well s~irr~d vessèl~' c~n be ex~re~5ed ~
D~1~Ye~y:~ra~ D/~t = D F/V
elivé~y~volume~ L:= - ~ln~Df~3 aximum~ef~1uent concentration: ~ = DJV
:D: :~amount o~ drug in the adaptor Do ~i~itial amount of drug ~n the adaptor t ~ 112~
: :
~i ~
WO 9~/11056 P~CI/US93/09394 . . .
212833~3 - 18 -F: diluent f low rate V: volume of ~ol ution in the ~daptor The drug delivery rate, volume, 2nd maximum effluerlt concentration from a vessel exhibiting plug flow can be expressed ~s:
Delivery rate: dD/dt = F Do/V
Delivery volume: L = V (D,f, ~))/Do Maximum ef f luent cont:entration ~ DJV
D- amount of drus~ in the adaptor ~' 10 Do initial amount of drug in the adaptor t: time F: diluent flow r~te ,, .
, ~ V: volume of solution in th~ adaptor The a~ove expressis:~ns for rate of deli~ery from the 15 ~ two ve sel type show that th~ delir~3ry rate is directly proportional to the flow rate and invg~r~ely proportio~al to the volume of sollltit:sn in ~he v~s~el~, Therefore, as the ~mixing in the adaptor 10 approaches ~ er o~ the two ide;~l systems ~ de~;cribed, by adjustin~g th~ volume of the 0 :~: solution: in: t~e adaptor, the :delivery rate to the Z : - ~
adraini~tration ~;~t ~an be ~g~ern~2d.
The~ above~: expressions: ~alss3 indic~te ~hat ~he delivery~ volume~is~direc:tiy~proportional to the ~olume : af:solution~in~the adaptor I0; and the maximum ~ffluent concentration is inversely proportional to the solution volume in the adaptor. Therefore, as the mixing ' in the adaptor lO approaches either of th~ two ideal systems describ~d, both parameters f~r a ~i~en drug ~n be controll~d~by adjusting the so1ution volume in the : adap~sr.
The internal geometry of the adaptor lO can be designed to ef~ect mixing of the diluent and drug solut:ion in the adaptQr lO which will consequently affect WO 9~tl1056 PCl/US93/Og394 21~3~
-- 19 -- . ., the ra~e of drug delivery from the adaptor 10 tci the administratiQrl set. The fluid path o~ the adaptor 10 can be design~d to af ~ect the mixing and consl3~uently the delivery kinetic:s from the adaptor. By changing the positions o~ the ~luid inlet and outlet, the mixing of the adaptor 10 for a given drug solution can range from approximat~ly plug flow to approximating a well-stirred vessel .
Referring now to Figures 5 and 6, an ~odiment of the fluid path within the aàaptor is illustrat~d. In the illustrated embodiment, the îluid path of the adaptor 10 illustrated in Figures 1 and 4 is mo~ified. To this end, the fluid flow paths in the lower section 118 of the embodiment uf ~igures 5 and 6 axe su~stantially similar to that of the &leeve and cannula illustrated in Figures 4. However, the fluid flow paths of the ~luid outlet within the ~irst seckion 140 are modified.
~o this ~nd ~ the embodiment of the adaptor 110 illu trated ~ ~in Figure S, instead of a cannula structure ~hat extends into the ~irst section ~140, a T-shaped fluid flt~w path 126 is provid~d. Th~ fluid flow path 126 includ~3s a~lower cannul~ structure 127 :lbut ~:ncludes an upper T shaped structure 12 9 . Fluid ~low ou~ O:e the first se~tion 140, as~ illus~rated in Figur~s S ~nd ~, is ~ through two ~op nin~s 130 and 131 of the T- haped struc:ture 1~6.
Instead o~ the shell structure 28 of Figures 1--4, fluid ~lows ~ into the ~irst se6tiorl 140 through an extended flow path 128. The ~xtend~d fl~w path includes an outlet 138: loç:ated near a top of the first se::tion 140. This: creatPs a fluid flow within the first sec~ion 140 illustrated in Figure 5.
:
WC~94/11056 P~r~US~3/09394 .
.
212833~j - 20 ~
Accordingly, the f luid inlet, with respect to the first ~ection, is distal and the fluid outlet is proximal relative to the docking site. The distance D can be modified to yield optimal drug delivery parameters for a given drug, Figures 7 and 8 illustrate another embodlment of the adaptor 210. In this embodim~nt, the cannula 22~ and shell 2~8 extend for substantially the æame ~istance into the first section 240. Hcwever, a tube ~9 i5 connected to the inl~t 23Q of the cannula ~26 allowing the fluid outlet path to be m~dified within the first section 240.
In the il~ ustrated e~bodiment, the tube 229 and ~hereby~fluid out1et path is positioned ne~r the wall 214 at a ~o~om of the first s~ç:tion 2~0. In this version, :L5 ~ again, the ~luid inlet,~ into the ~irst section 240, is distal and~ the fluid~ s:)utlet i~3 proximal relativ~ to the , docking ~;ite.:: ~he dist~nt:e D c:an be mod~fi~d to yield opSimal drug delivery par~me er: for ~ given drug.
~igure 9 illustrates a ~urth~r~ embodiment of the 20 : ~ ~ adaptor 310 :present ~ inv~ntiorl. In this embodiment, again, the fluid outlet p~th 326~ e~ined by a q~-~haped me~ er~ The~fluid inle~ pat~ is defin~d by an extended : ~ ~ m~mber 328 that exte~ds near a top of the ~irst section ~: : 340~
:
25T~e fluid inlet~ 338 is therefo~e distal and the outlet 330 proximal to the docki~g sit~. The inl~t 338 is p~sitioned above ~he solution le~els. The ~luid inlet 338 is cons~ru~ted so that it cr~ates dropl~s of fluid ;; accordingly, as diluent ~nters th~ adaptor 310, it drops , ~ 30into the solution. Ths drops of diluent falling into the :~ adaptor solution will increase the mixing in the adaptor : 310. The 1Ocation of the fluid ou~let can be modified ;~ ~ so as to optimize drug delivery for a given drug.
' WO 94J11056 ~r/USg3/09394 :, ~ - ~12~33~
In an ~mbodiment, it is possibl~3 for the adaptox lO
:~ to be designed to contain drug in a liquid ~tate within the first s~ction 40., The drug ormul~tion c~n th~xe~y be store~ in the a~aptor body. A site ~or vial 5~ ac::ess :.~ Stherefore would not be necessary.
desi~ed, the fluid, drug or diluent, can `be a ~rozen solu1:ion stored in the adaptor lO. The solution then being thawed and the adaptor 10 docketed to the Mainstream~ accass site~
10P.lthous~h the adaptor 10 in a preferred embodiment, is provid~d to the end u~er containing diluent, the 1. adaptor may be provid~d to the end user without diluent.
., A~ iIlustrat~d irl Figures lO-1~, a method for filling the adaptor 4~0 with diIuent is illustrated .
15In the illu~t:rated embodiment, the adaptor 410 .. : includ~s a ::onduit 411 that is in fluid communication with the f irst section 4 ~ 0 . The opera~or plugs the conduit 41;1~from the adaptor 41Q into an acce~; sit~ 413 ;1 ~ of an ~ ontainer 415. This can he the IV c:ontainer that i~ uséd ~o~admlnister the drug to ~h~ patient in the ad~:inist~ation~ se~:. The op~rator then squeezes the `fl@xible~chamber; 460 of the adaptor body 410 expelling a~ir inko ~he~ IV cont~iner 415, as illu~ra~d in Figure lOo ~ Ref~rring ~now ko Figure 11, by releasing the walls 460 of th~ ada~ptor 410, diluent 421 will be drawn into the adaptor 410~ As il~ustrated in Figure 2, ater the desired amount of diluent is transferred intc~ the adapts:r ::
~:: 410j the conduit 411 would be clamped o~f, using a clamp 450 02 other: means, and the a~aptor used a~ scribed `~ above.
:Of c:ourse, a variety of other mearls can be used for filling the adaptox.
'~
WO 94/11056 PCr/US93/0939 212833~
It should be understood that various ~hanges and modifications to the presently pr~f~rred embodiments described herein will b~ apparent to tho~e skilled in the art. Such changes and modi~ications can b~e made without departing from the spîrit and sc:ope of the present inv~ntion and without diminishing its attendant advarltages. It is therefore intsnded that such changes and modifications be covered by the appended claims.
~ . :
~ A
~ ~ ' :
' '
i ~ P ~ c I F I C _T O ~
AD~TO~ ~OR D~G D~ Y
ACKGROUND 0 ~ ~ Q~
S The present inven~ion relates general~y to the delivery of a beneficial:agen~ to a patient or in~o a system fsr later delivery to a patient. .,. More specifical~y, the present invention relates to an improved~drug delivery system.
For many applications, drugs can be mixed with a diluent before being delivered, ~or example, ; intravenou~ly~to~ a patient. The diluant can be, for example, a dextrose solution, a saline solu~ion, or even watex.~ To~thi~ ~nd, many drugs are suppli~d in powdered 15 ~ form and~packaged in:ylass vials~ Other drugs, such as ome:~chemotherapy dru~s, are~pa kaged i~ glass vials in : a~iquid~s~ate~
: Powd~red~rug ~can be recons~itu~d by u~ilizing a syrinqe~ Q~inje~t~ uid into~a via1:~ fsr~mix m ~; the 20 ~ syringe ~Ye~tually withdrawing ~t~e ~ixed~ soluti~n from he~vial.~ hQn~a drug mu~t::be~dilut~d be~ore delivery to-a~p~ti0nt,~the~drug is often injeot~d into~a container of~:diluen~ a~ter it is~reconstl~uted~ a container can be connected~to~an~administration~ t fo~ del~very ~o ~he 25~: pa~ent.~
Drugs~may be paokaged separa~e ~r ~ the dilu~nt ~or vari~ous:;rea~ons. One of the ~mo~t important reas~ns is that many ~d~ugs~do n~t retai~their~hemical:and`physical : :stability~when~mixed with a diluent and ~thus cannot be ~ s~ored for any: substantial period o;f ti~e. Also, drugs are oftsn :packag~d separately from thP diluent be:cause : : ;: many companies that manufacture drugs are~no~ engage~ in ~ : ~
~ , ~ :
.
WO 94/110~6 P~/US93/~9394 2128~3~ - 2 -the business of prvviding medical ~luids and con~airlers for intravenous delivery, and vice versa.
Therefore, doctors, nurses, pharmacists, or other medical personnel must mix the drug anc~ diluent. This presents a number of problems. The rec:on~titution pxocedur~3 is time consuming ancl re~uires aseptic techniqtaes. The operator must pro~ide the proper à~îue~t and a syrislge b~ore b~3ginning. The reconstitution procdure should be perfonned preferably or under pre~erably sterile conditions. This re~irement requires the opera~or~:tc~ be more cau~ious, thereby c::onsuming more ~ime. ~dditionally, terile ~ondit.iorls are o~en hard to ~aintain. In some instances, a lamin~r ~low hood may be required :under w~ich the: recorlstitution proc:~dure is 15 ~ perf orm~d r ~ ~
A furth~r~ concern is that so~ drugs, such as chemoth~r~py ~ ~rugs, are ~ toxic Expo~;ur~ OI the operator to l~he ~drug during res:on ti~u~ion can be dangerous, ~ ~ p~cially~ he operator~ works ~with such drug~ on a 0~ slaily ba~is ~and~ is ~ repeatedly expos d to them.
lthough a~ter a drug is ~con~ti~uted arld withdrawn into ~ ~yrins~ barrel, the~ drug can, ~n sQme instanc:es, be: inje~ ed ~ oediately into a pa~ient,~ more typi6~ally, howev~r~ ~he:~reconstituted drug is injee~ed from the yringe in~ o ~ la~:ger conkainer of solutic~n for connectiorl to an in~ravenou~ adminis~ration set.' A
larger contai~er of solutio~ may be necessary because oft~n the ~reconstituted drug in the syringe is at su ::h a conc:entration as to ~ause ~local toxici~y in the vein~
30 : of a patient~ near the injecl:ion site where the needle pierc~s khe skin:O This can crèate severe vein irritatio~
: which can be harmful .
WO g4tl 1056 PCr/US93/09394 212~33~
Addi l:ionally, even though th~ proper dos~ of medic:ation may be in the syringe, immediate in; ection into the patient ' s blood stream can create a condition of systemic: toxicity wherein the level oiE drug concentration in the patient ' s entire blood system is dangerously high. Yet anc~ther reason for not making an inj ection f rom the syringe directly into the patient is that such an injection creates an additional injectic)n ~ite into the patient; this can be painful for the 9 0 patient and provides another opportunity ~or infection.
For these reasons, the reconst~ tuted drug is more : ~ typically injected into a diluent ::o~stainer.
A number of drug: delivery syst~ms are known.
: In one delivery sy~tem that is curr~ntly used, a 15 : drug containe~ ~ in a ~ vial in a solid state is ~; ~ reoon~titutéd~ witb :: a: predetermined Yolume of di~uent :; usin~ a nêedle and syringe. The vial csntaining he drug and:~ soltation~ ~i5~; then mated :~onto zLn :intravenous a~ inistrat~ion~ se~. The :drug is~delivered to a patierlt 2 0 as diluent`~flows through ~he vial to the patient ~arrying rith ~ ~it~ thé ~ dic~olved d~g . ~ ~ ~
ano~her~:IV drug deli~ery ~sy~te~s, the drug olutiQ~ is~ packaged in ~lexible plas~ic cont iners.
So~e;drugs~packaged:in this manner may:be stored at room : 25 temper~u~e~and the drug is deliver~d by ~onnecting ~he container ~to an intravenous ~dminisl:rat~on s~t. ! Some dru~s paclcaged in this manner may be stored in a ~rozen sta~te in: order~ to: improve drug sta~llity. In th~se cases, the ~ drug ~olution must ~ be: thawed and then 3~0 ~ connected ~ ~ o an :intravenous adminis~ra~ion set for deliv@ry to~ the patient.
Another system requires drugs to be con1:ained in a special ~vial. An ac~ivated vial is then raal:ed to a ::
, . ~ .. . , ,, . = . . . . .. ... , . . .. . ~ . ~ z WO94/11056 PCT/US93/~939~
2 12833~3 4 _ special container. The vial stopper is re~oYed and ~he drug is ~rans~erred to th~ container by flushing the vial with the diluent in the container. The d~ug is delivered by connecting the container with the dissolved drug to an intra~enous ad~inistration set.
Drugs can also be delivered intravenously via a syringe pump. Briefly, a dose of reconstitute~ drug solution ~s withdrawn by a sy~ing~. The drug solution in the syri~ge is then re~rigexated or frozen until u5e.
The drug solution is brought to room emperature a~d infused into a patient via a syringe pump.
There are some disadvantages with some o~ th~ above systems and~procedures. On of the di~advantag~s is drug ~: waste. ~ Due to chemical and physical instability, once 1~ ~ a:soIid dru~ is;reconstituted with diluent tor a ~rozen formulation~ is thawed~ it cannot be ~tored for any ubstantial~amount of: tim~ Therefor~, if the drug s:olut~on~is:~not~ administered ~o the patient within a given period of~time, the drug~:~must be discard~d. Drug ~waste can;~be a ~ve~y costly expeno~ to a hospital p~ar~acy.~
S~me~:~of the current pro~e~ure~ ~or intravgnous administrat;i~on~are labor intenæive. As pr~viously noted, recon~titution of a drug wi~h a needle and syringe is time consuming and~re~uir~s an aseptic snvironment.
Li~ewise, e~posure o~ the opèra~or to the drug may b angerous~, especially if the operator works with the drug on a daily basis. Of course:,:need~e sticks may expose : healthcare~ professionals to hazardous di~eases and ~ 30 ~ infection~
::;: A further disadvantage of some of the above procedures~i~ that they require a s~condary IV
:: : :
.
W~ 94/1 ~056 PCr/U593/0939 _ 5 ?1283 :
administration set for delivery of the drug. The secondary set can be cumbersome f or both the patient and the clinicianO Elimination of the secondary set (,along with the n~edle and syringe) may also reduce solid waste and disposal costs.
.'. U.S. Pat~nt No. 4,850,978 disclo~es a dru~ delivery system for delivering drugs to patients and/or recons~itution of a drug. The system inclu~es a cartridgç for introduclng a beneficial agent into a fluid . 10 conduit for delivery of the agen~ to a patient. The cartridge includes a ri~id hollow tube and an agent containing chamber slidably mounted at least partially within the hollow tube . In a f irst, pre-use position, : ~ khe ch~mber extends farther from the hollow tube th~n it ,~
i;15 does in a second position. A cannula is mounted ts the ~i bol 1 ow tub~ extending oppos ite the chamk~er . When the c ~ chaI~Iber is in tbe second positic: n, the cannula pierc:as the closu~e msans~ creatirlg a 10w path.
U.S. Patent~ No. 4, 804, 366 also discloses a c~rug 20 delivery system including an adapter ~having an improved 9! ~ flow path ~e4ns providing bo~h an inlet and an outlet ~o the agent containing chamber of a cartridge. The ; ~ ~:; cartridg~: an~ adapt~r~ permit a ~single opening through the injection sites~at:opposite ends of the flow path means, : 25 : while still~ permitting simultaneo~ flow both into and out of ~e char~ber.~ An adapter and a cartridge is pro~,rided, including a rigid c:annula with an inlet and an outl t: and ~ the: shell substantially coaxial with and spac~d rom the c:aImula intermediate o:E the annula inlet 3 0 and tha canr~ula outle~ so tha~ ~he hell of the cannula defines a channel :ther~between. Both the camlula inlet and the canmlla outlet are ad~ptable to ~Eorm a single :: :
W094~1l056 PCT/~S~3J093 ;
. ?i 21283~
piercing opening in a resi1i~nt injection site associa~ed with the cartridgeO
.SUMM~RY OF ~HE INV~ION
~he present invention provides an improved drug de1iv~ry systemO The sy~tem faci1itates the reconstitution and i~trav~no~s administration of a beneficial agent. Generally, pursuant to the present invention, an adaptor is provided that provides a site for connection to an in-line IV et, a site for connection to a via1 containing a bene~icia1 agent, and ~he adaptor includes at 1eaet an upper section for cont~ining a volume of diluent, the upper sectio~
including portions thereof that can be biased inward1y;
: ~ in a preferred embodiment, the portions that can be ~iased inwardly are f1exib1e walls. A cannu1a can be : mounted within:the adaptor. To this end, a deYice ~is pro~id~d for coupling a irst container~inc1uding a benefi:cial agent ~o a ~econd member.:~ In;~ an ~embodiment, the ~device includes a ~substantia;lly;hollow member havin~a spike moun~ed within a;wa1l~that divid~s the substantia11y hollow me~ ~r into a irst and~second se:ction~ ~he s~cond ~ection inc1udes mean~ for;;:~receiving at least a ~ortîon of ~ fir t con~ainer.~ The~sùbstantia1ly~ho110w:member inc1udes a wall that defines an exterior of the ~irst section that is:subs~ntially flexi~le. In an embodiment,~ the h~110w mem~er~has a~ ube like shape.
A num~r of differe~t cannu~a and f10w path : &tructures~within~the ho1low member:are possible pur uant to the pre~ent in~ention. In an embodiment, a shell circum-cri~bes~ a portion of the cannu1a and defines a ~; : channel~having an inlet and an out1et. The shell and cannula can extend for the same distance into the ~pper : : :
::
.
WO 9~/1 10~6 PC~I`/US93/0939~
212~33~
section or the shell and cannula can extend a~t different distances ir~to the upper section. In an embodiment, the device includes two c:allnulas locat~d thereirl.
For use with an in-line IV set, the presen~
S invelltion also provides a cartridge for introducing a bene~icial ag~nt into a fluid conduit or delivery of the benef icial agent. In an embodiment, the cartrid~e includes a hollow tube having a cannula mounted therein def ining a channel having an inlet and an outlet . A
shell circumscribes a portion of the hollow tube and def ines a c:hannel also having a~l inlet and an outlet .
~he hollow tube includes a wall member dividing the hollow tu~e into ~n upp~r sectior~ ancl le~wer section, the ~:hannels of~ ~he cannula and sh~ll passing through the ` 15 wall. The upper section is ~;o cons~ruc~d and arranged to reGeiye at least a portion of the vial including a benefic:ial agellt. The upper ses:tion î~ defin~d, at least in p~rt, `by ~;ubstantially flexible walls.
Prefer~bly, the upper section is di~vîd~d înto a ~0: sec~îon for~ :housîng a diluent and a ~op portîon ~or rec~îving a por~ion of a vial.
Preferably~ the hollow: me~er incIudes mQans for pî~rcing a closure of the: vîal when the Yîal îs received by the upper ~;ection.
~:: 25 A ~thod of delîv~rîng a drug i also provîded. The ~ethod c:ompri~es the steps of- providi~g an ~daptor încluding an upper section havin~ ~t lea~;t par~ially f le~xîble walls and a cannu}a provîding f }uîd : ~ :
colomunîcakion between the upper ~ection and an outlet of : ~ : 30 the c:annula; proYidîng the upp~r sec~ion with a diluent:
couplîng a vial ~of beneficîal ag~ant to ~he upper ~e tîon.
and e~tablîshing ~luîd communicatîon be~ween an interior c)f the vîal and the upper section; causing fluid to flow .
WO 94/1 105~ PCr/US93/0~394 . .
.~ .
212833~
into the vial by, at least in part, squeezing at least a portion o~ the walls of the upper s~ction; allowing a resultant product to f low f rom the vial into th~ upper section: and causing the resul~ant produc~ to flow through the outlet of the cannula.
- ~ue to the flexible walls that defin~ the first sec:tion, diluent c:an be easily added to the vial. . This allows the drug contain~d within the vial to be re::onstituted and/or mixed with the diluent in the vial.
The resultant product can then be tran~erred back to ~he adaptor .
By utilizing different cons~ructions of the adaptor, including the cannula and shell arrangement loeated therein, drug delivery pro~iles can b~ modif ied . This allows a v~riety of drugs ~o be delivered utilizirlg the ' adaptor.:
An advantage of the present invention is that it provid~s an adaptor that llows an in-line IV s~t to be u ed ~with any off-the-shel~ dnlg vial.
P. fu~h~r ad~antage of the pre~ent invention is that J ~ ~ it could short:en product developmental tiDle5 ~ince all : drugs cQntained in their respective manu~acturer's vials have es~ablished ~xpiration.
Moreo~rer~,~ an advantage of the present invention is ~: 25 that it :r~duces pharmacist's time and the additional expe~se~ with respect to the use uf needle~ and syringes.
And further, an advantage of the present invention is th~t the :adaptor is user fri~ndly, for examp~e, a nurse can activate and re~onstitute the drug in a sqngle 31) 5't~p still further, an ad~antage of the present inv ntion is that it reduces waste, the activation~reconstitution i:
.
WC~ ~4/1 1~56 PCI/US93/09394 212~33 procedure can ~e done immediately . pFior to administration .
An advan~age of the presen~ invention is that it does not re~uire a specially designed vial and accor~lingly, it eliminates the cost ~r putting drugs into specially designed trials.
Additiosl211y, an advantage of the present invention is that it reduces waste in t::ontrast to some sy~tems wherein once the spe~ially designed vial is placed into an on-l ine IV system, it must be used; because the adaptor of the present invention is not activated until immediately prior to administrationt this greatly reduces the potential for drug waste.
~: Furthennore t an advantage of the present invention i5 tha~ a lpiggy baclc is not re~ired.
A~other adYantage of the pre~ent inven~ion is tha~
the adap*or c:æl allow~ the delivery o drugs in volumes as low as; a~ bolus inj~c~ior~ with :a~syringe or in volum~s and conc~ntrations similar to intraverlous drip infusion.
: Additional features ~nd advantages of the preserlt invention ar~ describèd: in, and will be appar~n~ from~
: the detailed: descript~on of the presently pr~ferred embodiments: and from~the dra~ins~s~.
2 5 Figure 1 illu .trates a perspecki~e ~iew of an emhodim~nt! of the ~adàptor of the pxesert inventi~sn.
: ~: Figure: 2 illustrates an ~mbodi~ent OI the adaptor of the pr~sent invention wher~in a vial has ~een mated to the adaptor.
Fi~ur~ 3 illusl:rates a persp~ctiv~ ~iew of the adaptor and Yial arrangement o~ Figure 2 wh rein diluent from the adaptor has }: een aslded to the ~ial .
, :
.
WO94/11056 PCT/U~3~09394 212833~
Figure 4 illustrates the vial a~d adaptor arra~gem~nt oX Figure 2 mated to an infusicn ~Q~.
Figure 5 illustrates an embodiment of the adaptvr of the present invention.
Figure fi illus~rates an enlarged perspective view of the flow paths of the embodimen~ of Figure S with parts broken away.
Figure 7 illustrates a furth~r embodiment of the adaptor of the present invention.
Fiqure 8 illu~tra~es a cross-seGtional view of the cannu}a of the adaptor of Figure 7 taken along lines VIII-VIII. ~ :
~: Figure 9 illustrates still a further embodiment of he adaptor of the present inv~ntion.
Figures 10-l2~illustr~te perspe~tive views of an ~: ~ embodim~nt o~th2 present inventi~on illus~rating a m~thod for filling~the~ adaptor with a diluent.
:DETAILED DESCRIPTION~ ~
~: 20 The~pr~s~nt i~vention pr w ides ad~ptoxs~:for coupling a ~i~l containing :a benefi~ia1~ag~nt tQ an~ in-line IV
s~ dditionally,: the present~ invention provides improYe~ ~ethod~:for admini tering a:~drug: to a patient~
As ~ set~ ~or~h ~ in detail hereinafter, due to the construc~ion of the a~aptor sf the present invention, it : can b~ utilized with most any in~ra~nbus drug. Tb thls nd~,~the adaptor~can be modified~to~proYide d~ug delivery profiles a~llowing the administration~ oX many ~aried : drugs.
Referring now to Figure l, an embodim@nt of the daptor l0 ~is illustrated. As illustrat~d, the adaptor 10 preferably comprises a substantially tubular shaped cartridge 12 that is divided by a wall l4 into an upper ~0g4~ P~/U~93/09394 212~33~
section 16 and a lower section 18. The lower section 18 comprising a substantially rigid m~mber having a key wall 20. The wall 14 is mounted across the cartridge 12 and defines the starting point for the key wall 20.
In the preferred embodiment illustrated, a cannula 26 extends through the wall 14. The cannula 26 defines a channel 27. Additionally, a generally cylin~rical shell 28 extends from both sides of ~he wall 14.
The shell 28 is spaced from th~ cannula 26 with the shéll, in the embodiment illustrated in Figure 1, encompassing *he cannula but being shorter at either end of the cannula. The cannula 26 includes an inlet and an outlet 30 and 32:, respectively~ Pr~fer~bly, the inlet ~ and the outlet 30 and 32 of the cannula 26 are blunt.
:~: 15 ~ Of cour.e, i~ desiredl either or both of these members could be point~d. ~ :
The ~s:hell 28 is:interm~diate of the cannula inlet and outl~t~30 and 32. The cannula 26 and~ ~heIl 28 defin~
a second chann~l 34 therebetween. In a preferred : 20 ::~embodiment, ~the periphery of the cannula 26 is circular : ~ along its~ien ~ h. Similarly, ~h~ internal surface of the shell 2~ is~ preferably arcuate ~an~ preferabIy circular : :along its;~length.~ ~
he second~ch~nnel 34 inc}udes a channel inlet 36 : 25 d@fined between the shell 28~and ~he cannula 26, short ~: o~the cannulajoutlet 32. Slmilarly, the seGond ~hann;el :~ : : includes a channel outlet 38 defined by tha shell 28 and ~ ithe cannul~ , short of the c~nnula inlet 30.
;~ ~ : : The cannula 26 is secured to the ~ 8 while ` 30 ~ still maintaining an open flow path through the channel : inlet 36, the channel 34, and the ch~nnel outle~ 38 : Thu ~ a v~ry small flow path is created ~utside a single cannula with precision.
.
~094/1l056 PCT/~S53/09394 ~12833~
The upper s ction 16 of the cartridge 12 is de~iqned to preferably receive a diluent. To this ~nd, in the preferred embodiment illustrated, the upper section 1 i~cludes a first and second section 40 and 42, respectively. As illustrated in Figur~ 2, the first section 40 is designed to house the diluent 43.
In order to prevent the diluent rom flowing from the first æection 40 out through the channels 27 and 34, as illustrated in Figure } a sheath 44 is provided for covering ~he end of the cannula and shell 28.
Preferably, ~th~ sheath 44 is substantially similar to ; that dîsclosed in U.S. patent application Serlal NoO
:~ 07/573,529 :en itled: 'IS~EATH ~OR C~NNUL~", the ;~ disclosure af whîch îs încorporated herein by ref~rence.
As set forth in::that pate~t application, the sheath 44 provides~a water tight s2al th~r~by preventing any of the dilu~nt ~rom leakin~ out of either o~ the channels defined~by~the:~cannula 26 or shell 28.
owever~, the sheath:44 i~ o so constructed and arran~ed ~hat~aven when us d wi~h a blunt:@nd~d cannula 26, ~he:sh~ath~will rip, n~ot core, upon the xertion o~
: ~ s~ficient:~orce by the blunt end of the cann~la again~t the~walls:46. This allows~the blunt ~nd of the : cannula:26 ~to be receîv~d withîn an injec~ion sîte without ~irst havin~ to manually remove the sheath 44.
The sheath 44 will fold back ~lo~g the cannula 26 and the sh~11 28~:in~:an s~cordion~fashion. This will allow ~he : : blun~ end of th~ cannula:2~ and shell ~8 to enter the .
in3ection site, but preYent the sheath 44 ~rom enterîng the injection site.
: Due to the use of the ~heath; the entîre first se tion 40 of the adaptor 12 can be ~illed with diluent îf desired. Addîtionally, if desired, a remo~able cover :
W0~4/1105~,fi PCT/USg3/09394 212833~
- 13 ~
i ,, 47 can be provided to protect the sheath 44 prior to use ~ of the cartridge.
i To divide the upper s~ction 16 into ~irst and second ; sertions 40, and 42" 2 wall 48 is pro~ided. Preferably, , 5 the wall 48 includes means for piercing a vial. In ~he J, - preferr~d ~mbodiment illustrated, ~he wall 58 includ~eis a spike 50 that provides fluid com~,unication be~we~n the :, first and second sections 40 and 42. The wall 48 ,~ pr~vents diluent hous2d in the adaptor lO from l~,,aking out of a top of the first section 40 of the ad,aptor lO.
The spike 50 provides maans f'or pro,viding fluid ~4 communic~ion between the first section~,0 of the adaptor 1 : }0 and a vial 54 to be ~nrketed on ~he second section 42 :
of th~ adap~or.: Of course, any pierring means that ~5 allows ~luid flow betw~en the vial 54 and th~,~ adaptor lO
c~n be used. As illustrated, pre~'erably, the spike 50 includes a~foil seal 56 to preYent le~kag~ of the diluent prior to docking;with a vial 54,. Additionally/ to insure the-steri1ity of the spike 50, a removable co~er 58 can ~e~proYided.~
In~the preferr~d ~mbodiime~t illustr,~ted,) th~e spike , 50~is:located~so as to be recessed from a plane deifined by~an~:open~end of~the second ser~tion 42. 8ecause the spike ~SO;~is~;recesse~, this ac~s ~o reduce accidental ~l~sti~kæ~ of personn~Pl hahdling the adaptQr lO as well as : pre~ent t ~ ~h çontamination. . ~ .
.j : If de5~ired, the second section 42 can i~clude on an interior surface bumps (not shown3 having a sloped side facing the open end of the second section~ Such a . -structure assists in s~curing a vial 54 to the adaptor ~: ~ 10. ~n example of such a structure i5 set f orth in PCT
~`~ ; PU~lishQd Application No. W091/11152, the disclo~ure of : which is hereby incorporated herein by reference.
.
..~. , wo 94/1 10S6 Pcr/US93/0939~
....
~12333~ - 14 -As illustrated in Figure 2, in USB , a vial 54 is mates:l with the adaptor 10. To this ~nd, at l~ast the top portion 56 of the vial 54 is received in the sec:ond sectîon 42 of the adaptor 10. This causes the spike 50 to pierce a rubber stopper 5~ of the vial 54, establishing fluid communication be~ween tl:~e cartridge 12 and the vial S4. Due to the construction of the cartridge 12, the c:artridge carl mate with any standard off the-shelf vial 5~ containing a beneficial agen~.
Pursuant to the presen~ invention, at least a po~tion of the walls 60 that define the first section 40 can be biased inwardly, as illustrated iI~ phantom lines in Figure 1. Pre~rably, at least a portisn o~ the wall~
60 are construct~d from a flexible materi~l. The : :
:: 15 material, however, should ~e su~fi~iently rigid to pro~ide stabil:ity to~ tlle adapt:ar l~, but allow the walls 60 to be biased inwardO In a pre:f~rred ~bodiment, the erltire walls 60;are flexib.le. Collv~rsely, the walls 61 that: define ~the upper :section 40/ :i~ d~sir~d, can be 2 0 rigid .
s illustrated~in Figure 3, in order to reconstitute or dilu1:~ a ~drug: 65: coDtain~d in ~he ~rial 54, the adaptor l0 i~ turned~ upside dowr~ iluent 43 contained in the ad ptor lO~ is ~then forces~ into the vi~l 54 by squee~ing :: 25 th~ ~lexible walls 60` of the adaptor. This forces the diluent 62 fro~n the adaptor lO in~o th~ in~erior of ~he mated druq vial~ 54.
: Th~ drug 65 contained within the vial 5~ is thPn allow~d :to~ dissolve andjor mix with the diluent. The : ~ ~ 30 resultal-t drug solution is then transferred back into the adaptor lO by holding the adaptor in an upri~ht position such that the solution is at the topp~r end of the vial 54 . The adaptor lO is then co~pres~ed f orcing air into .
. WO94/11os6 PCT~US93/0~394 2~3~; -the vial 54. The higher pressure in the vial 54 then~orces the liquid from the vial into the adaptor 10.
Referring now to Figure 4, the adaptor 10 can ~hen connected to an IV administration set, for example, the Mainstream~ administration set aYailable from ~axter Healthcare of Deerfield, Illinois. The drug that was contained in the ~ial 54 can now be deliv~red to the patient. To accomplish this, the adaptor lO is docketed on a receptacle 64. The recept~cl~ 64 includ s upper and Iower fitments 66 and 68. The upper ~i~ment 66 includes an inlet 79. The lower fitm~nt 68 includes the outlet 72. A pierceabl~ resealable injection site 73 i~ mounted within the upper fitme~t 66 of the receptacle 64. An example of:such an IV administratio~ set is disclosed in UOS. Patent No~ 4~,804,366, the ~iscl~ ur~ o~ which i5 : inco ~ oEated h~rein by~refer~na~. ~
The reo~ptacle 64 in~ludes a re~ nt divider 74 trapped betwe~n th~:upper and lower ~ nts 66 and 6B
of the receptacle:~64. T~e resilient~divlder 74 defines a~ narrQw~thr~ugh: bore 75 dix~ctly~below the resilient pierceable~;injection sit~ 70. B~or~ ~he: cartridg~ 10 o~f the~pre ent~i m ention is engaged wi h~the receptacle 64, fluid~lowing~rom a par~nteral container 76 flows through the~fluid conduit 78 and through a receptacle inlet 79 whereon it flows into the xeceptacl~ above the . dividin~ ~plate 74, ~through the:~ through bore 75 and down6~ream~0 the rec~p~acle outlet 72. Fluid then flows downstream:to the~ patient7 As illu~trated in Figure 4,`when the cartridge 12 30~ is mount~d~ sn the receptacle 64 the cannula ~6 and the shell 28 ~pierce the resilient in~eck~on site 70. The cartridge:l2 continues to b~ urged do~nwardly so that the cannula outlet 30 enters the thro~gh bore 75 and is .
WO ~/~0~6 PCT/~Sg3/0~394 212833~ ~ 16 -i li~uid-æ~alingly engaged by ~he resilient divider 74 around the periphery o~ the cannula outlet 32.
Upon engag~ment of the cartridge 10 and receptacle 6~, as illustrated in Figure 4, liquid flowing into the receptacle at the inlet 79 is prev~nted ~rom passing through the through bore 75 and the receptacle because the resilient divider 74 has been seal~d abou~ the cannula outlet 32 portion at the through bore 7~. Thus, 1 iquid ent~ring the receptacle enters the channel inlet 36, flows through the channel 34, and enters the ~irst section 40 at the ch nnel outlet 38.
In an e~bodiment, as liquid risas wi~hin t~e first , : section 4Q, it will continue to rise until it reaches the ~ ~ cannula inlet 30, whereupon liquid begins to exit the i~ 15 chamber thrQugh the cannul a 26 downst~eam through the ~ cannula outlet 32. ~i ~ id exiting the cannula 26 has an 3~ appropriate concentration for th~ beneficial agent mixed therewith f:or deliv~ry to the patient. In the ~:: illustra~ted embo~iment, ~he upward liqu d flow path ~; 20 created within~the first section 40 by the ~hell 28, cha~nnel 34, and~ cannula 26 crea~e~ a densi~y gradient within the fir~t ~ction:4:0 such that the conc~ntra~ion .~ of drug wi~hin the liquid exiting at the cannula outlet . ~
32 will not be so high as to create local toxicity of the patien~.
A5 illustrated in the Figures, many e~bodiments af the adaptor 12 are possible. The drug delivery to the patient mus~ m~et clinical guidelines. For IV therapy, these guidelines may include parameters -~uch as delivery rate, deli~ery volume, and delivery concentration.
Typically, the clinical guidelines for drug delivery sp~cify a range in which the drug delivery parameters : should lie. Drug delive~y rates, concentrations, ~nd ,, .
W(:~ 9~/110~6 Pcr/us93/o~3g4 212833~
volumes can be controlled by modification of the adaptor 10 .
The geometry o~ the adaptor lO, diluent f~ow path, drug solution den ity, and drug solution volum~ all can be tailored to yield a desired drug deliv~ry pro~ile for a particular drug. ~ Adaptor lO design modi~ic~tions can yie1d drug del ivery r~tes which range f rom bol.~s IV
inj action to IV drip infusion .
The den~ity of the drug solutic: n relative ~o that O:e the diluent has a major impact on the rate o~ drug delivery from the ~ adaptor lO. ~or a given adap~or design, the r 1ative d~nsity of the diluexlt and drug solution determîne the mixing c:haracteris~ics in the adaptor lO during delivery to the administratîon set.
~ The adaptor ;10 may ~ be desiyned~ so that by varying only : ~ th~ rela~i~re ~density of ~he drug solution and diluent, he ;de1iv~ rate:~froxn~ the adaptor; can ;range ~rom ~olus IV to i~je~tion~to IV~drip in~usi~n.~
rug `~ deliver~ rates, ~rolNmes tvolume r~quired to ~ deli~r~the;~dose), arld concentration~s are func:~ions of h~ vo1ume~of~so1ut:ion~:in the adaptor l0.~ Therefvxe, by : ao~trollin~ h~ olution:Yolume in:tha adaptor lO drug de~livery ~o:~the~pa~i~nt can:b@ ~overned.
Thé::drug:~:de1~ivery:rate,~o1ume, a~d~maximum ef~luent ~ :con~ntration ~from ~a "well s~irr~d vessèl~' c~n be ex~re~5ed ~
D~1~Ye~y:~ra~ D/~t = D F/V
elivé~y~volume~ L:= - ~ln~Df~3 aximum~ef~1uent concentration: ~ = DJV
:D: :~amount o~ drug in the adaptor Do ~i~itial amount of drug ~n the adaptor t ~ 112~
: :
~i ~
WO 9~/11056 P~CI/US93/09394 . . .
212833~3 - 18 -F: diluent f low rate V: volume of ~ol ution in the ~daptor The drug delivery rate, volume, 2nd maximum effluerlt concentration from a vessel exhibiting plug flow can be expressed ~s:
Delivery rate: dD/dt = F Do/V
Delivery volume: L = V (D,f, ~))/Do Maximum ef f luent cont:entration ~ DJV
D- amount of drus~ in the adaptor ~' 10 Do initial amount of drug in the adaptor t: time F: diluent flow r~te ,, .
, ~ V: volume of solution in th~ adaptor The a~ove expressis:~ns for rate of deli~ery from the 15 ~ two ve sel type show that th~ delir~3ry rate is directly proportional to the flow rate and invg~r~ely proportio~al to the volume of sollltit:sn in ~he v~s~el~, Therefore, as the ~mixing in the adaptor 10 approaches ~ er o~ the two ide;~l systems ~ de~;cribed, by adjustin~g th~ volume of the 0 :~: solution: in: t~e adaptor, the :delivery rate to the Z : - ~
adraini~tration ~;~t ~an be ~g~ern~2d.
The~ above~: expressions: ~alss3 indic~te ~hat ~he delivery~ volume~is~direc:tiy~proportional to the ~olume : af:solution~in~the adaptor I0; and the maximum ~ffluent concentration is inversely proportional to the solution volume in the adaptor. Therefore, as the mixing ' in the adaptor lO approaches either of th~ two ideal systems describ~d, both parameters f~r a ~i~en drug ~n be controll~d~by adjusting the so1ution volume in the : adap~sr.
The internal geometry of the adaptor lO can be designed to ef~ect mixing of the diluent and drug solut:ion in the adaptQr lO which will consequently affect WO 9~tl1056 PCl/US93/Og394 21~3~
-- 19 -- . ., the ra~e of drug delivery from the adaptor 10 tci the administratiQrl set. The fluid path o~ the adaptor 10 can be design~d to af ~ect the mixing and consl3~uently the delivery kinetic:s from the adaptor. By changing the positions o~ the ~luid inlet and outlet, the mixing of the adaptor 10 for a given drug solution can range from approximat~ly plug flow to approximating a well-stirred vessel .
Referring now to Figures 5 and 6, an ~odiment of the fluid path within the aàaptor is illustrat~d. In the illustrated embodiment, the îluid path of the adaptor 10 illustrated in Figures 1 and 4 is mo~ified. To this end, the fluid flow paths in the lower section 118 of the embodiment uf ~igures 5 and 6 axe su~stantially similar to that of the &leeve and cannula illustrated in Figures 4. However, the fluid flow paths of the ~luid outlet within the ~irst seckion 140 are modified.
~o this ~nd ~ the embodiment of the adaptor 110 illu trated ~ ~in Figure S, instead of a cannula structure ~hat extends into the ~irst section ~140, a T-shaped fluid flt~w path 126 is provid~d. Th~ fluid flow path 126 includ~3s a~lower cannul~ structure 127 :lbut ~:ncludes an upper T shaped structure 12 9 . Fluid ~low ou~ O:e the first se~tion 140, as~ illus~rated in Figur~s S ~nd ~, is ~ through two ~op nin~s 130 and 131 of the T- haped struc:ture 1~6.
Instead o~ the shell structure 28 of Figures 1--4, fluid ~lows ~ into the ~irst se6tiorl 140 through an extended flow path 128. The ~xtend~d fl~w path includes an outlet 138: loç:ated near a top of the first se::tion 140. This: creatPs a fluid flow within the first sec~ion 140 illustrated in Figure 5.
:
WC~94/11056 P~r~US~3/09394 .
.
212833~j - 20 ~
Accordingly, the f luid inlet, with respect to the first ~ection, is distal and the fluid outlet is proximal relative to the docking site. The distance D can be modified to yield optimal drug delivery parameters for a given drug, Figures 7 and 8 illustrate another embodlment of the adaptor 210. In this embodim~nt, the cannula 22~ and shell 2~8 extend for substantially the æame ~istance into the first section 240. Hcwever, a tube ~9 i5 connected to the inl~t 23Q of the cannula ~26 allowing the fluid outlet path to be m~dified within the first section 240.
In the il~ ustrated e~bodiment, the tube 229 and ~hereby~fluid out1et path is positioned ne~r the wall 214 at a ~o~om of the first s~ç:tion 2~0. In this version, :L5 ~ again, the ~luid inlet,~ into the ~irst section 240, is distal and~ the fluid~ s:)utlet i~3 proximal relativ~ to the , docking ~;ite.:: ~he dist~nt:e D c:an be mod~fi~d to yield opSimal drug delivery par~me er: for ~ given drug.
~igure 9 illustrates a ~urth~r~ embodiment of the 20 : ~ ~ adaptor 310 :present ~ inv~ntiorl. In this embodiment, again, the fluid outlet p~th 326~ e~ined by a q~-~haped me~ er~ The~fluid inle~ pat~ is defin~d by an extended : ~ ~ m~mber 328 that exte~ds near a top of the ~irst section ~: : 340~
:
25T~e fluid inlet~ 338 is therefo~e distal and the outlet 330 proximal to the docki~g sit~. The inl~t 338 is p~sitioned above ~he solution le~els. The ~luid inlet 338 is cons~ru~ted so that it cr~ates dropl~s of fluid ;; accordingly, as diluent ~nters th~ adaptor 310, it drops , ~ 30into the solution. Ths drops of diluent falling into the :~ adaptor solution will increase the mixing in the adaptor : 310. The 1Ocation of the fluid ou~let can be modified ;~ ~ so as to optimize drug delivery for a given drug.
' WO 94J11056 ~r/USg3/09394 :, ~ - ~12~33~
In an ~mbodiment, it is possibl~3 for the adaptox lO
:~ to be designed to contain drug in a liquid ~tate within the first s~ction 40., The drug ormul~tion c~n th~xe~y be store~ in the a~aptor body. A site ~or vial 5~ ac::ess :.~ Stherefore would not be necessary.
desi~ed, the fluid, drug or diluent, can `be a ~rozen solu1:ion stored in the adaptor lO. The solution then being thawed and the adaptor 10 docketed to the Mainstream~ accass site~
10P.lthous~h the adaptor 10 in a preferred embodiment, is provid~d to the end u~er containing diluent, the 1. adaptor may be provid~d to the end user without diluent.
., A~ iIlustrat~d irl Figures lO-1~, a method for filling the adaptor 4~0 with diIuent is illustrated .
15In the illu~t:rated embodiment, the adaptor 410 .. : includ~s a ::onduit 411 that is in fluid communication with the f irst section 4 ~ 0 . The opera~or plugs the conduit 41;1~from the adaptor 41Q into an acce~; sit~ 413 ;1 ~ of an ~ ontainer 415. This can he the IV c:ontainer that i~ uséd ~o~admlnister the drug to ~h~ patient in the ad~:inist~ation~ se~:. The op~rator then squeezes the `fl@xible~chamber; 460 of the adaptor body 410 expelling a~ir inko ~he~ IV cont~iner 415, as illu~ra~d in Figure lOo ~ Ref~rring ~now ko Figure 11, by releasing the walls 460 of th~ ada~ptor 410, diluent 421 will be drawn into the adaptor 410~ As il~ustrated in Figure 2, ater the desired amount of diluent is transferred intc~ the adapts:r ::
~:: 410j the conduit 411 would be clamped o~f, using a clamp 450 02 other: means, and the a~aptor used a~ scribed `~ above.
:Of c:ourse, a variety of other mearls can be used for filling the adaptox.
'~
WO 94/11056 PCr/US93/0939 212833~
It should be understood that various ~hanges and modifications to the presently pr~f~rred embodiments described herein will b~ apparent to tho~e skilled in the art. Such changes and modi~ications can b~e made without departing from the spîrit and sc:ope of the present inv~ntion and without diminishing its attendant advarltages. It is therefore intsnded that such changes and modifications be covered by the appended claims.
~ . :
~ A
~ ~ ' :
' '
Claims (49)
1. A device for coupling a first container including a beneficial agent to a second member comprising:
a substantially hollow member;
a fluid path, having a channel including a first and second opening, mounted within a wall that divides the substantially hollow member into an upper and lower section; and the first section including means for receiving at least a portion of a first container and the substantially hollow member including walls that define an exterior of the upper section that are capable of, at least in part, being biased inwardly thereby exerting a pressure on fluid contained within the first section.
a substantially hollow member;
a fluid path, having a channel including a first and second opening, mounted within a wall that divides the substantially hollow member into an upper and lower section; and the first section including means for receiving at least a portion of a first container and the substantially hollow member including walls that define an exterior of the upper section that are capable of, at least in part, being biased inwardly thereby exerting a pressure on fluid contained within the first section.
2. The device of Claim 1 wherein the substantially hollow member includes walls that define the lower section that are substantially rigid.
3. The device of Claim 1 wherein the substantially hollow member has a tube-like shape.
4. The device of Claim 1 including a shell circumscribing a portion of the fluid path and defining a second channel having a first and second opening.
5. The device of Claim 1 wherein the substantially hollow member includes means for piercing a closure of the first container when the first container is received by the first section.
6. The device of Claim 1 wherein the fluid path is a cannula.
7. The device of Claim 6 wherein the cannula includes at least one blunt end.
8. The device of Claim 1 wherein the fluid path terminates in a structure having a T-like cross-sectional shape.
9. The device of Claim 4 wherein the first opening of the fluid path and the first opening of the shell extend into the upper section at substantially the same level.
10. The device of Claim 4 wherein the first opening of the fluid path extends into the upper section a greater distance from the wall than the first opening of the shell.
11. The device of Claim 4 wherein the first opening of the shell extends into the upper section a greater distance from the wall than the first opening of the fluid path.
12. The device of Claim 1 wherein the walls are substantially flexible.
13. The device of Claim 1 wherein the first section includes a conduit, coupled to the walls, for allowing the first section to receive fluid.
14. The device of Claim 1 wherein the first section includes an upper wall located at a distance from the wall dividing the hollow member, the upper wall includes a spike and defines an upper area for receiving a portion of a vial.
15. The device of Claim 1 wherein the first section includes a liquid.
16. A cartridge for introducing a beneficial agent into a fluid conduit for delivery of the beneficial agent comprising:
a hollow tube;
a cannula mounted within the hollow tube defining a channel having an inlet and an outlet;
a shell circumscribing a portion of the hollow tube and defining a channel having an inlet and an outlet;
the hollow tube including a wall member dividing the hollow tube into an upper section and lower section, the channels of the cannula and the shell passing through the wall; and the upper section being so constructed and arranged to receive at least a portion of a vial including a beneficial agent, the upper section being defined, at least in part, by substantially flexible walls.
a hollow tube;
a cannula mounted within the hollow tube defining a channel having an inlet and an outlet;
a shell circumscribing a portion of the hollow tube and defining a channel having an inlet and an outlet;
the hollow tube including a wall member dividing the hollow tube into an upper section and lower section, the channels of the cannula and the shell passing through the wall; and the upper section being so constructed and arranged to receive at least a portion of a vial including a beneficial agent, the upper section being defined, at least in part, by substantially flexible walls.
17. The cartridge of Claim 16 wherein the substantially hollow member includes walls that define the lower section that are substantially rigid.
18. The cartridge of Claim 16 wherein the substantially hollow member includes means for piercing a closure of the vial when the vial is received by the first section.
19. The cartridge of Claim 16 wherein the cannula includes at least one blunt end.
20. The cartridge of Claim 16 including a sheath for covering at least an end of the cannula and the shell that extends into the lower section.
21. The cartridge of Claim 20 wherein the sheath includes a body member defining an interior for receiving at least a portion of the end of the cannula, the body member including a first end and a second end, the second end having an opening for receiving at least a portion of the cannula, the first end including a wall member so constructed and arranged as to rip upon the exertion of a sufficient perpendicular force by the end of the cannula, and the body includes side walls extending between the first and second end, the side walls are so constructed and arranged so as to slide back along the cannula toward the second end upon the tearing of the first end by the cannula and the application of a sufficient force upon the side walls.
22. The cartridge of Claim 16 wherein an opening of the cannula that extends into the upper section terminates at a location closer to the wall then an opening of the shell that extends into the upper section.
23. The cartridge of Claim 16 wherein an opening of the cannula and an opening of the shell terminates at approximately the same position in the upper section.
24. The cartridge of Claim 16 wherein an opening of the cannula that extends into the upper section is coupled to a fluid tube having an outlet.
25. The cartridge of Claim 24 wherein the outlet of the fluid tube is located in juxtaposition to the wall.
26. The cartridge of Claim 16 including a fluid conduit in fluid communication with the upper section for providing fluid flow into the upper section from a fluid source.
27. The cartridge of Claim 16 wherein the upper section includes a liquid.
28. The cartridge of Claim 16 wherein the upper section includes a frozen beneficial agent.
29. The cartridge of Claim 16 wherein the upper section is divided into a first section for receiving a fluid and a second section for receiving the portion of the vial wall, and the upper section includes a spike that provides fluid communication between the first and second section.
30. The cartridge of Claim 29 including a closure for covering at least a portion of the spike prior to use of the cartridge.
31. A drug delivery device comprising:
a cartridge body including an upper section defining a vial receiving area and means for puncturing a top of a vial so received, the cartridge body including two channels through a wall member that divides the cartridge body into the upper section and a lower section, the upper section being defined, in part, by substantially flexible walls; and a vial including a beneficial agent.
a cartridge body including an upper section defining a vial receiving area and means for puncturing a top of a vial so received, the cartridge body including two channels through a wall member that divides the cartridge body into the upper section and a lower section, the upper section being defined, in part, by substantially flexible walls; and a vial including a beneficial agent.
32. The device of Claim 31 wherein the cartridge body includes walls that define the lower section that are substantially rigid.
33. The device of Claim 31 wherein one of the two channels terminates in a structure having a T-like cross-sectional shape.
34. The device of Claim 31 wherein a first opening of each of the channels extends into the upper section at substantially the same level.
35. The device of Claim 31 wherein a first opening of each of the channels extends into the upper section at a different location.
36. The device of Claim 31 including a sheath for covering at least an end of each of the channels that extend into the lower section.
37. The device of Claim 31 wherein the upper section includes a liquid.
38. The device of Claim 31 wherein the upper section includes a frozen liquid.
39. The device of Claim 31 wherein the vial receiving area of the upper section includes rigid walls.
40. The device of Claim 31 wherein the means for puncturing the top of vial is a spike.
41. A method for drug delivery comprising the steps of:
providing an adaptor having an upper and lower section divided by a wall and two flow paths between the upper and lower section;
locating a liquid in the upper section of the adaptor;
coupling a vial containing a beneficial agent to an upper section of the adaptor;
establishing fluid communication between the upper section and an interior of the vial;
biasing a portion of a wall defining the upper section toward an interior of the upper section to cause the liquid to flow into the vial;
allowing a resultant liquid in the interior of the vial to flow into the upper section; and coupling the adaptor to a device for delivering the resultant liquid to a patient.
providing an adaptor having an upper and lower section divided by a wall and two flow paths between the upper and lower section;
locating a liquid in the upper section of the adaptor;
coupling a vial containing a beneficial agent to an upper section of the adaptor;
establishing fluid communication between the upper section and an interior of the vial;
biasing a portion of a wall defining the upper section toward an interior of the upper section to cause the liquid to flow into the vial;
allowing a resultant liquid in the interior of the vial to flow into the upper section; and coupling the adaptor to a device for delivering the resultant liquid to a patient.
42. The method of Claim 41 wherein the vial is coupled to the adaptor before fluid is housed in the upper section.
43. The method of Claim 41 including the step of removing a cover from the upper section prior to coupling the vial to the adaptor.
44. The method of Claim 41 including the steps of:
providing a sheath for covering an end of the flow paths that extend into the lower section; and causing the sheath to be removed from the openings of the flow paths as the adaptor is coupled to the device.
providing a sheath for covering an end of the flow paths that extend into the lower section; and causing the sheath to be removed from the openings of the flow paths as the adaptor is coupled to the device.
45. The method of Claim 44 including the step of causing the sheath to rip as the adaptor is coupled to the device.
46. The method of Claim 41 wherein the device is an IV administration device.
47. The method of Claim 41 including the step of causing a fluid to flow into the adaptor, and allowing the fluid to mix with the resultant liquid to create an administratable fluid for delivery to a patient.
48. The method of Claim 41 including the step of delivering the administratable fluid to a patient.
49. The method of Claim 41 including the step of providing the upper section with means for piercing, automatically, a portion of the vial as it is coupled to the upper section.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7/978,555 | 1992-11-19 | ||
| US07/978,555 US5385547A (en) | 1992-11-19 | 1992-11-19 | Adaptor for drug delivery |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2128335A1 true CA2128335A1 (en) | 1994-05-26 |
Family
ID=25526208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA 2128335 Abandoned CA2128335A1 (en) | 1992-11-19 | 1993-10-04 | Adaptor for drug delivery |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5385547A (en) |
| EP (1) | EP0623033B1 (en) |
| JP (1) | JP2926440B2 (en) |
| AU (1) | AU666596B2 (en) |
| CA (1) | CA2128335A1 (en) |
| DE (1) | DE69323729T2 (en) |
| WO (1) | WO1994011056A1 (en) |
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-
1992
- 1992-11-19 US US07/978,555 patent/US5385547A/en not_active Expired - Fee Related
-
1993
- 1993-10-04 JP JP51207194A patent/JP2926440B2/en not_active Expired - Fee Related
- 1993-10-04 AU AU52966/93A patent/AU666596B2/en not_active Ceased
- 1993-10-04 CA CA 2128335 patent/CA2128335A1/en not_active Abandoned
- 1993-10-04 EP EP93923201A patent/EP0623033B1/en not_active Expired - Lifetime
- 1993-10-04 WO PCT/US1993/009394 patent/WO1994011056A1/en active IP Right Grant
- 1993-10-04 DE DE1993623729 patent/DE69323729T2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE69323729T2 (en) | 1999-09-30 |
| EP0623033B1 (en) | 1999-03-03 |
| DE69323729D1 (en) | 1999-04-08 |
| JP2926440B2 (en) | 1999-07-28 |
| WO1994011056A1 (en) | 1994-05-26 |
| AU5296693A (en) | 1994-06-08 |
| JPH07503170A (en) | 1995-04-06 |
| EP0623033A4 (en) | 1995-05-24 |
| EP0623033A1 (en) | 1994-11-09 |
| US5385547A (en) | 1995-01-31 |
| AU666596B2 (en) | 1996-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |