CA2129167A1 - Single Needle Recirculation System for Harvesting Blood Components - Google Patents
Single Needle Recirculation System for Harvesting Blood ComponentsInfo
- Publication number
- CA2129167A1 CA2129167A1 CA2129167A CA2129167A CA2129167A1 CA 2129167 A1 CA2129167 A1 CA 2129167A1 CA 2129167 A CA2129167 A CA 2129167A CA 2129167 A CA2129167 A CA 2129167A CA 2129167 A1 CA2129167 A1 CA 2129167A1
- Authority
- CA
- Canada
- Prior art keywords
- blood
- return
- during
- cycle
- donor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0209—Multiple bag systems for separating or storing blood components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
- A61M1/303—Details having a reservoir for treated blood to be returned
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
- A61M1/305—Control of inversion point between collection and re-infusion phase
- A61M1/306—Pressure control, e.g. using substantially rigid closed or gas buffered or elastic reservoirs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3601—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit
- A61M1/3603—Extra-corporeal circuits in which the blood fluid passes more than once through the treatment unit in the same direction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
- A61M1/3644—Mode of operation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
- A61M1/3696—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3643—Priming, rinsing before or after use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0415—Plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
- A61M2202/0427—Platelets; Thrombocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
Abstract
A single needle system for withdrawing donated blood, processing the blood to harvest components such as platelets, and returning processed blood to the donor through the single needle.
Processing is performed by a centrifuge which separates blood components into stratified layers with a buffy coat containing platelets and white blood cells stably interfacing a red blood cell layer. Blood is withdrawn during a draw cycle and returned to the donor during a return cycle. A recirculation system is provided so that blood flows at a reduced rate through the processing system during the return cycle in order to minimize return cycle time while maintaining the stable position of the interface between buffy coat and red blood cell layers. A
storage bag receives processed blood during the draw cycle and blood is squeezed from the bag during the return cycle, a portion returned to the donor and another portion entering the recirculation path. A pressure sensor is located in the return path to indicate an empty storage bag upon a precipitous drop in pressure. In that manner an immediate switch to the draw cycle is made to further minimize return cycle time. To still further minimize the return cycle time, flow resistance in the return path is minimized with more than 80% of the flow resistance in the return path associated with the needle.
Processing is performed by a centrifuge which separates blood components into stratified layers with a buffy coat containing platelets and white blood cells stably interfacing a red blood cell layer. Blood is withdrawn during a draw cycle and returned to the donor during a return cycle. A recirculation system is provided so that blood flows at a reduced rate through the processing system during the return cycle in order to minimize return cycle time while maintaining the stable position of the interface between buffy coat and red blood cell layers. A
storage bag receives processed blood during the draw cycle and blood is squeezed from the bag during the return cycle, a portion returned to the donor and another portion entering the recirculation path. A pressure sensor is located in the return path to indicate an empty storage bag upon a precipitous drop in pressure. In that manner an immediate switch to the draw cycle is made to further minimize return cycle time. To still further minimize the return cycle time, flow resistance in the return path is minimized with more than 80% of the flow resistance in the return path associated with the needle.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/110,432 US5437624A (en) | 1993-08-23 | 1993-08-23 | Single needle recirculation system for harvesting blood components |
US08/110.432 | 1993-08-23 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2129167A1 true CA2129167A1 (en) | 1995-02-24 |
CA2129167C CA2129167C (en) | 1999-06-08 |
Family
ID=22332974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002129167A Expired - Fee Related CA2129167C (en) | 1993-08-23 | 1994-07-29 | Single needle recirculation system for harvesting blood components |
Country Status (5)
Country | Link |
---|---|
US (1) | US5437624A (en) |
EP (1) | EP0649663A1 (en) |
JP (1) | JP2909390B2 (en) |
AU (1) | AU675547B2 (en) |
CA (1) | CA2129167C (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112004569A (en) * | 2018-04-26 | 2020-11-27 | 日机装株式会社 | Blood purification device |
Families Citing this family (99)
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US5573678A (en) * | 1987-01-30 | 1996-11-12 | Baxter International Inc. | Blood processing systems and methods for collecting mono nuclear cells |
US5833866A (en) * | 1991-12-23 | 1998-11-10 | Baxter International Inc. | Blood collection systems and methods which derive instantaneous blood component yield information during blood processing |
US5681273A (en) * | 1991-12-23 | 1997-10-28 | Baxter International Inc. | Systems and methods for predicting blood processing parameters |
US5690835A (en) | 1991-12-23 | 1997-11-25 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US5639382A (en) * | 1991-12-23 | 1997-06-17 | Baxter International Inc. | Systems and methods for deriving recommended storage parameters for collected blood components |
US5676841A (en) * | 1991-12-23 | 1997-10-14 | Baxter International Inc. | Blood processing systems and methods which monitor citrate return to the donor |
US5730883A (en) | 1991-12-23 | 1998-03-24 | Baxter International Inc. | Blood processing systems and methods using apparent hematocrit as a process control parameter |
US6319471B1 (en) | 1992-07-10 | 2001-11-20 | Gambro, Inc. | Apparatus for producing blood component products |
US5630946A (en) * | 1995-02-15 | 1997-05-20 | Pall Corporation | Method for processing a biological fluid including leukocyte removal in an extracorporeal circuit |
US6022306A (en) | 1995-04-18 | 2000-02-08 | Cobe Laboratories, Inc. | Method and apparatus for collecting hyperconcentrated platelets |
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AU714650B2 (en) * | 1995-06-07 | 2000-01-06 | Baxalta GmbH | Blood processing systems and methods for collecting mono nuclear cells |
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CA3189781A1 (en) | 2020-07-21 | 2022-01-27 | Icu Medical, Inc. | Fluid transfer devices and methods of use |
US11135360B1 (en) | 2020-12-07 | 2021-10-05 | Icu Medical, Inc. | Concurrent infusion with common line auto flush |
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US4098275A (en) * | 1975-11-28 | 1978-07-04 | Dante Vincent Consalvo | Dual flow cannula set |
US4086924A (en) * | 1976-10-06 | 1978-05-02 | Haemonetics Corporation | Plasmapheresis apparatus |
US4094461A (en) * | 1977-06-27 | 1978-06-13 | International Business Machines Corporation | Centrifuge collecting chamber |
US4285464A (en) * | 1979-01-22 | 1981-08-25 | Haemonetics Corporation | Apparatus for separation of blood into components thereof |
US4223672A (en) * | 1979-02-08 | 1980-09-23 | Baxter Travenol Laboratories, Inc. | Variable volume plasma treatment chamber for an apparatus for the extracorporeal treatment of disease |
FR2519555A1 (en) * | 1982-01-11 | 1983-07-18 | Rhone Poulenc Sa | APPARATUS AND METHOD FOR ALTERNATIVE PLASMAPHERESE WITH MEMBRANE APPARATUS |
FR2548541B1 (en) * | 1983-07-07 | 1986-09-12 | Rhone Poulenc Sa | PLASMAPHERESE PROCESS AND APPARATUS FOR USE IN PARTICULAR FOR THIS PROCESS |
FR2548907B1 (en) * | 1983-07-13 | 1985-11-08 | Rhone Poulenc Sa | PLASMAPHERESE PROCESS AND APPARATUS FOR USE IN PARTICULAR FOR THIS PROCESS |
US4776964A (en) * | 1984-08-24 | 1988-10-11 | William F. McLaughlin | Closed hemapheresis system and method |
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US5178603A (en) * | 1990-07-24 | 1993-01-12 | Baxter International, Inc. | Blood extraction and reinfusion flow control system and method |
-
1993
- 1993-08-23 US US08/110,432 patent/US5437624A/en not_active Expired - Lifetime
-
1994
- 1994-07-29 CA CA002129167A patent/CA2129167C/en not_active Expired - Fee Related
- 1994-08-03 AU AU68861/94A patent/AU675547B2/en not_active Ceased
- 1994-08-12 EP EP94305976A patent/EP0649663A1/en not_active Ceased
- 1994-08-22 JP JP6196946A patent/JP2909390B2/en not_active Expired - Fee Related
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112004569A (en) * | 2018-04-26 | 2020-11-27 | 日机装株式会社 | Blood purification device |
CN112004569B (en) * | 2018-04-26 | 2023-08-18 | 日机装株式会社 | Blood purifying device |
Also Published As
Publication number | Publication date |
---|---|
CA2129167C (en) | 1999-06-08 |
JP2909390B2 (en) | 1999-06-23 |
US5437624A (en) | 1995-08-01 |
AU675547B2 (en) | 1997-02-06 |
JPH07163656A (en) | 1995-06-27 |
EP0649663A1 (en) | 1995-04-26 |
AU6886194A (en) | 1995-03-02 |
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