CA2131157A1 - Disposable inhaler ii - Google Patents
Disposable inhaler iiInfo
- Publication number
- CA2131157A1 CA2131157A1 CA002131157A CA2131157A CA2131157A1 CA 2131157 A1 CA2131157 A1 CA 2131157A1 CA 002131157 A CA002131157 A CA 002131157A CA 2131157 A CA2131157 A CA 2131157A CA 2131157 A1 CA2131157 A1 CA 2131157A1
- Authority
- CA
- Canada
- Prior art keywords
- powder
- compartment
- tape
- housing
- inhaler according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/001—Particle size control
- A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0043—Non-destructive separation of the package, e.g. peeling
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2206/00—Characteristics of a physical parameter; associated device therefor
- A61M2206/10—Flow characteristics
- A61M2206/14—Static flow deviators in tubes disturbing laminar flow in tubes, e.g. archimedes screws
Abstract
The invention relates to a disposable breath-actuated inhaler comprising a tubular housing forming an air flow path being open at both ends, one end forming an air inlet (4) and one end forming an air outlet (5), said housing comprising a compartment (3) for storing a phamaceutical powder to be inhaled. The compartment (3) for storing the pharmaceutical powder is located close to the air inlet (4) and is covered by a thin foil (6) sealing the compartment in an airtight way which can be removed from the compartment from outside the housing, said housing being shaped with a constriction (9) adjacent the powder compartment (3) such that a turbulent air stream will be obtained at the constriction upon inhalation which will lift the powder out from the compartment (3) and mix the powder into the air stream .
Description
~ WO93/17728 21311~ 7 PCT/EP93/00473 DI~PO~ABL~ IN%ALER_II
Technical fleld of the inventiQn.
The present invention relates to a breath-actuated disposable inhaler of the kind having a generally tubular shape and having two ends, one end forming an air inlet and one end forming an air outlet, the inhaler containin~ a pharmaceutical powder comprising particles of a respirable size which is to be inhaled.
Backg round of the invention.
Disposable, breath-actuated inhalers of the kind ~eccribed above are for instance disclosed in W0 89/~1348, US-A-4,265,236 and EP-A-0404454.
EP-A-0404454 discloses a disposa~ e, breath-actuated inhaler comprising a chamber for a pharmaceutical powder, said chamber being provided with an air inlet and with an air outlet~ The air inlet and outlet are covered ~y a common cover. The powder is disposed loosely in said comparatively large chamber which means that the powder not necessarily will be located at that : location at which the air flow is most efficient.
US-A-4,265,236 discloses a tubular disposable, breath-actuated inhaler comprising a flexible tube, the ends of which normally being sealingly inserted into each other. This kind of seal will not necessarily be moistu~e-proof. There furthermore is a risk that some amount of the powder may fall out of the inhaler when the ends of the tube ar2 pulled apart.
W093/17728 21 311 5 7 2 PCT/EPs3/oy~
W0 89101348, in the embodiment most of interest here, discloses a tubular, disposable inhaler which is sealed in both ends by means of twist-off caps. The pharmaceutical powder is loosely disposed in the s inhaler and, as in the other inhalers described above, there is a risk that some powder is lost when the inhaler is opened.
The objects of the invention are to provide a disposable inhaler of the kind described above in which the dose of pharmaceutical powder can be determined accurately and in which the pharmaceutical powder can ~ be stored hermetically sealed and moisture-proof. The dose delivered by different specimens of the sam~e inhaler should generally be constant. The inhaler finally should be easy to prepare for use and easy to use as well as being easy and cheap to manufacture.
Brief descri~tiQn of the inventive conce~.
:: The above objects are.achieved in that the disposable inhaler is provided with the features set forth in the appended main claim. Advantageous embodiments are set ~ 25 forth in the dependent claims.
: Brief description o~ the a~ended drawinqs.
: 30 IFig 1 shows a perspective view of an inhaler according to the invention, Fig 2 shows a perspective view of an inhaler according to Fig 1 but showing the two main parts of the inhaler in an unassembled state, Figs 3A - 3C show different stages in the opening of the powder compartment of the inhaler of Fig 1, ^ W093/17728 3 2131157 PCT/EP~3/00473 Fig 4 shows an end view of the air inlet of the inhaler in Fig 1, Figs 5 - 7 show different possible embodiments of the constriction adjacant the powder compartment.
Detailed descriptlon of a preferrçd embodiment of the ~nvention.
A preferred embodiment of the invention is disclosed in Figs 1 - 4. In Fig 1 the inhaler can be seen in a fully assembled condition and ready for use. As can be seen, the inhaler essentially comprises two elongate main parts, an upper part 1 which is made of a moulded sheet lS of plastic material and a lower part 2 preferably made of aluminium foil laminated with plastic. The upper part 1 is U-shaped with a substantially rectangular shape. The width of the upper part is several times the heightO The lower part is generally flat and the two parts thus form a tubular housing defining an air conduit or air flow path with an air inlet 4 and an air outlet 5. A part-spherical depression or recess 3 indicated with a dashed line is located close to the air inlet 4 . The recess 3 f orms a powder compartment 25 and is covered by a tape 6 which preferably is made of aluminium foil, also laminated with plasti¢. The recess 3 may also be provided with one or several small through-holes 24 in the bottom. The hole or holes 24 should be large enough to allow the entry of air into the recess from the underside of the lower part, but sufficiently small to prevent any part of the powder from falling out through the hole(s).
As indicated, the end of the part of the tape 6 covering the recess 3 is located between the recess 3 ~nd the air inlet 4. The tape is attached to the lower art 2 around the powder compartment by means of a W093/17728 2 1311~ ~ PCT/EP93/00~
..
relatively weak weld 22 which can be s~en in Fig 2. The end of the tape is attached by a comparatively large and thus stxonger weld in front of the compartment, as ~een in the intended direction of the air flow. The free part of the tape 6 is~bent backwards over the recess 3 and extends out through the air inlet 4. In this particular embodiment, the free part of the tape is guided and held by two conical projections 7,8 extending downwards from the upper part 1. The free part of the tape may be bent in a loop to ~he underside of the lower part 2 and attached to the lower part all around the recess 3 by a relatively weak weld, thus sealing the hole 24 and the recess 3. The tape should be sufficiently long to extend past the recess 3, thus forming a tab 25 to serve as a grip for tearing the tape away.
A constriction in the flow path in the form of a ridge - g oriented perpendicularly relative to the direction of the flow path is located above the powder compartment.
~: The ridge is formed as a depression 9 in the upper part 1. The ridge is delimited at each end by an abutment 10 .
The inhaler is further provided with deaggregation ~:~ means after the powder compartment, as seen in the direction of the intended air flow through the inhaler.
These deaggregation means comprise a number of oblique planar surfaces which are oriented at an angle of about 30 relative to the longitudinal direction of the inhaler, it surprisingly having been found that the most efficient angle of a planar surface relative to - the air flow direction for disintegrating powder agglomerations is about 30. Since the air flow will be deflected to some extent by the planar surface, the flow direction will not coincide fully with the longitudinal direction, but the above angle has been 2 1 ;~ 7 -~ WO93/17728 5 PCT/EP93/00473 chosen as being the best compromise. The angle can howsver be varied between 20 and 50 with a preferred range of 25 - 35.
The planar surfaces are oriented generally perpendicularly relative to the lower part 2, or at least as perpendicularly as the method o~ manufacturing the inhaler allows. The planar surfaces are located in such a way that their projections onto a cross-sectional plane substantially cover the entire cross-section of the inhaler. The projections preferably should overlap to some extent in order to ensure that any larger particles or agglomerations entrained in the air flow will impact on at least one such surface. In the preferred embodiment the planar surfaces ll, 12, 13, l4, 15, 16 ~re located on ~he upstream ends of two pairs of indentions 17, 18; l9, 20, formed into the sides of the upper part l and on the upstream end of a central depression 2l located between said indentations forming an island in the flow path. The downstream ends of said indentations and said depression taper in the - direction of the air flow and have a smooth, rounded shape in order to obtain good aerodynamic conditions without any areas where the powder entrained in the air flow could sattle.
The two main parts of the inhaler are shown separated in Fig 2. Apart from the details shown in Fig 1, the powder compartment 3 is shown opened, the tape 6 having been pulled outwardly through the air inlet. The shape of the (broken) weld 22 can be seen on the tape 6 and t around the powder compartment 3. As can be seen, the shape of the weld has been chosen to be the perimeter of a square oriented with one diagonal parallel with the longitudinal extent of the inhaler. This means that the disengage~ent of the tape from the lower part 2 will be facilitated since the tearing action will both W093/1772~ ~ 3 115 ~ 6 PCT/EPs3/oo~
start and end at a corner. Since the wel~ holding the inner end o~ the tape is broad and strong, the user will feel when the compartment has been uncovered by means of the increased resistance.
Figs 3A - 3c show different s~ages in the openiny of the powder compartment 3 by puiling the tape 6, thus exposing the powder 23. Fig 3A shows the tape 6 attached around the recess 3 on the under side of the - lower part, thus covering the hole 24 whilst leaving a tearing tab 25.
- The end viaw in shown in Fig 4 more clearly illus~rates the inter-relationship between the upper part l, the lower part 2, the powder compartment 3, the tape 6, the conical projections 7; 8, the ridge g and the abutments 10 .
When the inhal~r is to be used, the inhaler is held more or less hori20ntal with the flat half 2 facing downwards. The free end of the tape 6 is pulled by means of the tab 25, thus exposing the hole 23 and the powder in the powder compartment 3. The two conical projections 7, 8 will hold the tape 6 flat against the~
: 25 lower part 2 and thus prevent the tape from occluding the constriction in front of the powder c~mpartment.
The user then inserts the air outlet into the mouth and inhales throu~h the inhaler. The resultant air flow through the inhaler will become very turbulent in the Iregion of the constriction and the pharmaceutical powder will be lifted out of the powder compartment and mixed with the air flow. Any particles adhering to the tape may also be entrained with the air flow since the part of the tape originally covering the powder compartment aIso will lie directly in the flow path. By admitting air into the bottom of the recess 3, the through-hole 24 will counteract any subpressures in the 21~11S7 ~--. WO93/17728 7 : ~ PCT/EP93/00473 ., ' bot~om of the recess which might impede the lifting of the powder out of the recess.
Tests have shown that the dose leaving a typical powder compartment (e.g. about 0.5 mg) located at a constriction having an area of about 10 - 12 mm2 will remain essentially constant at air flow rates varying from 30 l/min to 60 l/min.
The powder-laden air will then flow from the con~triction to the deaggregation means. The angle of attack of the oblique surfaces will entail that t:he lighter particles, i. e. the particles within the respirable range, < 6~m, will be deflected from the surface without sticking thereto and thus mainly will follow the air flow, whereas tha heaver particles and agglomerates will impact on and rebound from the planar surfaces and in this way be broken up into smaller particles. As mentioned above, an angle of about 30 may be optimal.
In this case tests again have shown that the percentage of particles within the respirable range in the dose to be inhaled will remain substantially constant at air flow rates ranging from 30 l/min to 60 l/min.
That the dose of respirable particles remains substantially constant over a wide range of air flows is important in order to minimize the difference between patients with different inhalation capacities.
It should be noted that the tubular shape of the inhaler makes it possible to mount a rubber ball or ~, similar over the air inlet. By the means thereof the t powder could be ejected from the inhaler into the throat of the patient in synchronization with the breathing of the patient by a helper if the patient W093/177 ~ 3 1 15~ 8 PCT/EP93/0 should b~ incapable to use the inhaler by himself.
As mentioned above, the lower part 2 of th~ inhaler as well as the tape 6 preferably are made of aluminium foil laminated or coated with a suitable plastic. The aluminiu~ will ensure the desired protection against moistuxe whereas the plastic will ensure that the tape can be welded to the lower part and that the lower part can be welded to the upper part. The lower part may for instance consist of a aluminium foil having a thickness of 45 ~ which on one side is covered with a layer of oriented polyamide which is 25 ~ thick and on the other side is covered by a layer of polypropene which is 60 ~
thick. The upper part is preferably made of polypropene being 300 or 400 ~ thick. The upper part can be transparent so that the user can see if the dose has been ejected from the powder compartment.
The tape may be made of a laminate having a "peel"-effect comprising polyester, aluminium and a layer comprîsing a polymer mixture of p~lybuten and polypropene.
The choice of material in the inhaler should be adapted to the drug to be used. The above materials have been chosen with a specific drug (budesonide) in mind, these materials releasing a dose of this drug more easily.
The composition of the pharmaceutical powder of course ' 30 is quite optional and the powder may for instance comprise a pure active substance, a mixture`of ~; different active substances or a mixture of active substance(s) with adjuvant(s). It should be pointed out that the scope of choice of drugs is widened considerably due to the moisture-proof containment of the drug in the powder compartment.
,~ ~
2l3Ils7 ,_. WO93/17728 9 PCT/EP93/00473 The inhaler may be manufactured in the following way. A
series of half-spherical indentations are formed in a strip of laminated aluminium foil in order to shape powder compartments. If the indentations are to be provided with through-holes, these are also formed at this stage. The indentations are filled with drugs and are topped off by means of scrapers, which will ensure a substantially uniform size of the different doses. An aluminium tape laminated with plastic is then welded over each indentation and around ths indentation on the outside of the lower part.
- The lower parts are then welded to upper parts and the strip is cut to form individual inhalers which are rPady for packaging and use. The upper parts are moulded from sheet5 of plastic. In the moulding procedure care should be taken to ensure that the side walls of the upper part are as perpendicular as pos.sible relative to the upper side in order to ensure an air flow which is as uniform as pvssible throughout the entire cross-section of the inhaler. The function of the abutments lO primarily are to prevent that the ridge forming the constriction is distorted during the welding process.
Possible modificat'ons of the invention.
The invention of course can be modified in many ways within the scope of the appended claims.
Thus the ridge 9 forming the constriction can be designed in different ways in order to enhance the lifting action of the air flow on the powder. Some examples thereof can be found in Figs 5 - 7.
Fig S illustrates how the ridge 9 can be provided with a small hole 26 centrally above the powder compartment W093/~7728 ~ PCT/EP93/0 3. When the patient inhales through the inhaler, additional air will be directed more or less perpendicularly down into the powder compartment, thus enhancing the turbulent action in the vicinity of the powder compartment.
Figs 6 and 7 illustrate two alternative embodiments wherein the ridge has been provided with an edge 27 resp 28 oriented along tha longitudinal extent of the lQ ridge and which also will direct some air flow more directly into the powder compartment.
.
- These embodiments wîll however reguire a higher degree of precision in the manufacturing in order to obtain the desired effect than the embodiment described above and will therefore be more difficult to manufacture.
The ridge 9 forming the constriction has been illustrated as being generally trapezoid in cross-section and as being generally rectilinear inlongitudinal section. It should however ~e pointed out that the constriction may be shaped in many different ways within the scope of the appended claims.
The powder compartment can of course have another shape ~"
than a half-spherical shape and may for instance be elliptical, the minor axis thereof being parallel with the direction of the air flow, or may be otherwise trough-shaped. It is of course also possible to have ! several indentations, for instance if it is desire~d to increase the dose in an exactly defined way. As -~ ment~oned above, the powder compartment can be designed without the hole~s) 24. Two separate tapes furthermore ~-~ can be used to seal the recess ~ respectively the - 35 hole(s) 24.
, ~ .
The projections 7,8 can be shaped otherwise than f-;; W093/l77~8 11 ~ 5 7 PCT/~P93/0~73 conically and may for instance be shaped such that they direct a greater part of the air flow more directly past the powder compartment. They al~o could be integrated with the abutments 10.
The tape 6 could also be arranged in such a manner that it can be removed entirely from the lower part 2. In this case the projections 7,8 are not needed, at least not for the purpos~ of guiding and holding the tape.
The deaggregation means can be designed in other ways than in the form of planar surfaces oriented at an - angle of about 20 - 50 relative to the direction of the air flow. This angle can of course also be varied outside this range and the surfaces do not necessarily have to be planar.
The material in the lower part and the tape does not necessarily have to comprise aluminium and may be any ; 20 pla~tic material having the necessary impermeability and stiffness or having been treated to have these properties.
. j It is also conceivable to make the inhaler from a single sheet which is rolled or folded after having been moulded in an appropriate way.
Technical fleld of the inventiQn.
The present invention relates to a breath-actuated disposable inhaler of the kind having a generally tubular shape and having two ends, one end forming an air inlet and one end forming an air outlet, the inhaler containin~ a pharmaceutical powder comprising particles of a respirable size which is to be inhaled.
Backg round of the invention.
Disposable, breath-actuated inhalers of the kind ~eccribed above are for instance disclosed in W0 89/~1348, US-A-4,265,236 and EP-A-0404454.
EP-A-0404454 discloses a disposa~ e, breath-actuated inhaler comprising a chamber for a pharmaceutical powder, said chamber being provided with an air inlet and with an air outlet~ The air inlet and outlet are covered ~y a common cover. The powder is disposed loosely in said comparatively large chamber which means that the powder not necessarily will be located at that : location at which the air flow is most efficient.
US-A-4,265,236 discloses a tubular disposable, breath-actuated inhaler comprising a flexible tube, the ends of which normally being sealingly inserted into each other. This kind of seal will not necessarily be moistu~e-proof. There furthermore is a risk that some amount of the powder may fall out of the inhaler when the ends of the tube ar2 pulled apart.
W093/17728 21 311 5 7 2 PCT/EPs3/oy~
W0 89101348, in the embodiment most of interest here, discloses a tubular, disposable inhaler which is sealed in both ends by means of twist-off caps. The pharmaceutical powder is loosely disposed in the s inhaler and, as in the other inhalers described above, there is a risk that some powder is lost when the inhaler is opened.
The objects of the invention are to provide a disposable inhaler of the kind described above in which the dose of pharmaceutical powder can be determined accurately and in which the pharmaceutical powder can ~ be stored hermetically sealed and moisture-proof. The dose delivered by different specimens of the sam~e inhaler should generally be constant. The inhaler finally should be easy to prepare for use and easy to use as well as being easy and cheap to manufacture.
Brief descri~tiQn of the inventive conce~.
:: The above objects are.achieved in that the disposable inhaler is provided with the features set forth in the appended main claim. Advantageous embodiments are set ~ 25 forth in the dependent claims.
: Brief description o~ the a~ended drawinqs.
: 30 IFig 1 shows a perspective view of an inhaler according to the invention, Fig 2 shows a perspective view of an inhaler according to Fig 1 but showing the two main parts of the inhaler in an unassembled state, Figs 3A - 3C show different stages in the opening of the powder compartment of the inhaler of Fig 1, ^ W093/17728 3 2131157 PCT/EP~3/00473 Fig 4 shows an end view of the air inlet of the inhaler in Fig 1, Figs 5 - 7 show different possible embodiments of the constriction adjacant the powder compartment.
Detailed descriptlon of a preferrçd embodiment of the ~nvention.
A preferred embodiment of the invention is disclosed in Figs 1 - 4. In Fig 1 the inhaler can be seen in a fully assembled condition and ready for use. As can be seen, the inhaler essentially comprises two elongate main parts, an upper part 1 which is made of a moulded sheet lS of plastic material and a lower part 2 preferably made of aluminium foil laminated with plastic. The upper part 1 is U-shaped with a substantially rectangular shape. The width of the upper part is several times the heightO The lower part is generally flat and the two parts thus form a tubular housing defining an air conduit or air flow path with an air inlet 4 and an air outlet 5. A part-spherical depression or recess 3 indicated with a dashed line is located close to the air inlet 4 . The recess 3 f orms a powder compartment 25 and is covered by a tape 6 which preferably is made of aluminium foil, also laminated with plasti¢. The recess 3 may also be provided with one or several small through-holes 24 in the bottom. The hole or holes 24 should be large enough to allow the entry of air into the recess from the underside of the lower part, but sufficiently small to prevent any part of the powder from falling out through the hole(s).
As indicated, the end of the part of the tape 6 covering the recess 3 is located between the recess 3 ~nd the air inlet 4. The tape is attached to the lower art 2 around the powder compartment by means of a W093/17728 2 1311~ ~ PCT/EP93/00~
..
relatively weak weld 22 which can be s~en in Fig 2. The end of the tape is attached by a comparatively large and thus stxonger weld in front of the compartment, as ~een in the intended direction of the air flow. The free part of the tape 6 is~bent backwards over the recess 3 and extends out through the air inlet 4. In this particular embodiment, the free part of the tape is guided and held by two conical projections 7,8 extending downwards from the upper part 1. The free part of the tape may be bent in a loop to ~he underside of the lower part 2 and attached to the lower part all around the recess 3 by a relatively weak weld, thus sealing the hole 24 and the recess 3. The tape should be sufficiently long to extend past the recess 3, thus forming a tab 25 to serve as a grip for tearing the tape away.
A constriction in the flow path in the form of a ridge - g oriented perpendicularly relative to the direction of the flow path is located above the powder compartment.
~: The ridge is formed as a depression 9 in the upper part 1. The ridge is delimited at each end by an abutment 10 .
The inhaler is further provided with deaggregation ~:~ means after the powder compartment, as seen in the direction of the intended air flow through the inhaler.
These deaggregation means comprise a number of oblique planar surfaces which are oriented at an angle of about 30 relative to the longitudinal direction of the inhaler, it surprisingly having been found that the most efficient angle of a planar surface relative to - the air flow direction for disintegrating powder agglomerations is about 30. Since the air flow will be deflected to some extent by the planar surface, the flow direction will not coincide fully with the longitudinal direction, but the above angle has been 2 1 ;~ 7 -~ WO93/17728 5 PCT/EP93/00473 chosen as being the best compromise. The angle can howsver be varied between 20 and 50 with a preferred range of 25 - 35.
The planar surfaces are oriented generally perpendicularly relative to the lower part 2, or at least as perpendicularly as the method o~ manufacturing the inhaler allows. The planar surfaces are located in such a way that their projections onto a cross-sectional plane substantially cover the entire cross-section of the inhaler. The projections preferably should overlap to some extent in order to ensure that any larger particles or agglomerations entrained in the air flow will impact on at least one such surface. In the preferred embodiment the planar surfaces ll, 12, 13, l4, 15, 16 ~re located on ~he upstream ends of two pairs of indentions 17, 18; l9, 20, formed into the sides of the upper part l and on the upstream end of a central depression 2l located between said indentations forming an island in the flow path. The downstream ends of said indentations and said depression taper in the - direction of the air flow and have a smooth, rounded shape in order to obtain good aerodynamic conditions without any areas where the powder entrained in the air flow could sattle.
The two main parts of the inhaler are shown separated in Fig 2. Apart from the details shown in Fig 1, the powder compartment 3 is shown opened, the tape 6 having been pulled outwardly through the air inlet. The shape of the (broken) weld 22 can be seen on the tape 6 and t around the powder compartment 3. As can be seen, the shape of the weld has been chosen to be the perimeter of a square oriented with one diagonal parallel with the longitudinal extent of the inhaler. This means that the disengage~ent of the tape from the lower part 2 will be facilitated since the tearing action will both W093/1772~ ~ 3 115 ~ 6 PCT/EPs3/oo~
start and end at a corner. Since the wel~ holding the inner end o~ the tape is broad and strong, the user will feel when the compartment has been uncovered by means of the increased resistance.
Figs 3A - 3c show different s~ages in the openiny of the powder compartment 3 by puiling the tape 6, thus exposing the powder 23. Fig 3A shows the tape 6 attached around the recess 3 on the under side of the - lower part, thus covering the hole 24 whilst leaving a tearing tab 25.
- The end viaw in shown in Fig 4 more clearly illus~rates the inter-relationship between the upper part l, the lower part 2, the powder compartment 3, the tape 6, the conical projections 7; 8, the ridge g and the abutments 10 .
When the inhal~r is to be used, the inhaler is held more or less hori20ntal with the flat half 2 facing downwards. The free end of the tape 6 is pulled by means of the tab 25, thus exposing the hole 23 and the powder in the powder compartment 3. The two conical projections 7, 8 will hold the tape 6 flat against the~
: 25 lower part 2 and thus prevent the tape from occluding the constriction in front of the powder c~mpartment.
The user then inserts the air outlet into the mouth and inhales throu~h the inhaler. The resultant air flow through the inhaler will become very turbulent in the Iregion of the constriction and the pharmaceutical powder will be lifted out of the powder compartment and mixed with the air flow. Any particles adhering to the tape may also be entrained with the air flow since the part of the tape originally covering the powder compartment aIso will lie directly in the flow path. By admitting air into the bottom of the recess 3, the through-hole 24 will counteract any subpressures in the 21~11S7 ~--. WO93/17728 7 : ~ PCT/EP93/00473 ., ' bot~om of the recess which might impede the lifting of the powder out of the recess.
Tests have shown that the dose leaving a typical powder compartment (e.g. about 0.5 mg) located at a constriction having an area of about 10 - 12 mm2 will remain essentially constant at air flow rates varying from 30 l/min to 60 l/min.
The powder-laden air will then flow from the con~triction to the deaggregation means. The angle of attack of the oblique surfaces will entail that t:he lighter particles, i. e. the particles within the respirable range, < 6~m, will be deflected from the surface without sticking thereto and thus mainly will follow the air flow, whereas tha heaver particles and agglomerates will impact on and rebound from the planar surfaces and in this way be broken up into smaller particles. As mentioned above, an angle of about 30 may be optimal.
In this case tests again have shown that the percentage of particles within the respirable range in the dose to be inhaled will remain substantially constant at air flow rates ranging from 30 l/min to 60 l/min.
That the dose of respirable particles remains substantially constant over a wide range of air flows is important in order to minimize the difference between patients with different inhalation capacities.
It should be noted that the tubular shape of the inhaler makes it possible to mount a rubber ball or ~, similar over the air inlet. By the means thereof the t powder could be ejected from the inhaler into the throat of the patient in synchronization with the breathing of the patient by a helper if the patient W093/177 ~ 3 1 15~ 8 PCT/EP93/0 should b~ incapable to use the inhaler by himself.
As mentioned above, the lower part 2 of th~ inhaler as well as the tape 6 preferably are made of aluminium foil laminated or coated with a suitable plastic. The aluminiu~ will ensure the desired protection against moistuxe whereas the plastic will ensure that the tape can be welded to the lower part and that the lower part can be welded to the upper part. The lower part may for instance consist of a aluminium foil having a thickness of 45 ~ which on one side is covered with a layer of oriented polyamide which is 25 ~ thick and on the other side is covered by a layer of polypropene which is 60 ~
thick. The upper part is preferably made of polypropene being 300 or 400 ~ thick. The upper part can be transparent so that the user can see if the dose has been ejected from the powder compartment.
The tape may be made of a laminate having a "peel"-effect comprising polyester, aluminium and a layer comprîsing a polymer mixture of p~lybuten and polypropene.
The choice of material in the inhaler should be adapted to the drug to be used. The above materials have been chosen with a specific drug (budesonide) in mind, these materials releasing a dose of this drug more easily.
The composition of the pharmaceutical powder of course ' 30 is quite optional and the powder may for instance comprise a pure active substance, a mixture`of ~; different active substances or a mixture of active substance(s) with adjuvant(s). It should be pointed out that the scope of choice of drugs is widened considerably due to the moisture-proof containment of the drug in the powder compartment.
,~ ~
2l3Ils7 ,_. WO93/17728 9 PCT/EP93/00473 The inhaler may be manufactured in the following way. A
series of half-spherical indentations are formed in a strip of laminated aluminium foil in order to shape powder compartments. If the indentations are to be provided with through-holes, these are also formed at this stage. The indentations are filled with drugs and are topped off by means of scrapers, which will ensure a substantially uniform size of the different doses. An aluminium tape laminated with plastic is then welded over each indentation and around ths indentation on the outside of the lower part.
- The lower parts are then welded to upper parts and the strip is cut to form individual inhalers which are rPady for packaging and use. The upper parts are moulded from sheet5 of plastic. In the moulding procedure care should be taken to ensure that the side walls of the upper part are as perpendicular as pos.sible relative to the upper side in order to ensure an air flow which is as uniform as pvssible throughout the entire cross-section of the inhaler. The function of the abutments lO primarily are to prevent that the ridge forming the constriction is distorted during the welding process.
Possible modificat'ons of the invention.
The invention of course can be modified in many ways within the scope of the appended claims.
Thus the ridge 9 forming the constriction can be designed in different ways in order to enhance the lifting action of the air flow on the powder. Some examples thereof can be found in Figs 5 - 7.
Fig S illustrates how the ridge 9 can be provided with a small hole 26 centrally above the powder compartment W093/~7728 ~ PCT/EP93/0 3. When the patient inhales through the inhaler, additional air will be directed more or less perpendicularly down into the powder compartment, thus enhancing the turbulent action in the vicinity of the powder compartment.
Figs 6 and 7 illustrate two alternative embodiments wherein the ridge has been provided with an edge 27 resp 28 oriented along tha longitudinal extent of the lQ ridge and which also will direct some air flow more directly into the powder compartment.
.
- These embodiments wîll however reguire a higher degree of precision in the manufacturing in order to obtain the desired effect than the embodiment described above and will therefore be more difficult to manufacture.
The ridge 9 forming the constriction has been illustrated as being generally trapezoid in cross-section and as being generally rectilinear inlongitudinal section. It should however ~e pointed out that the constriction may be shaped in many different ways within the scope of the appended claims.
The powder compartment can of course have another shape ~"
than a half-spherical shape and may for instance be elliptical, the minor axis thereof being parallel with the direction of the air flow, or may be otherwise trough-shaped. It is of course also possible to have ! several indentations, for instance if it is desire~d to increase the dose in an exactly defined way. As -~ ment~oned above, the powder compartment can be designed without the hole~s) 24. Two separate tapes furthermore ~-~ can be used to seal the recess ~ respectively the - 35 hole(s) 24.
, ~ .
The projections 7,8 can be shaped otherwise than f-;; W093/l77~8 11 ~ 5 7 PCT/~P93/0~73 conically and may for instance be shaped such that they direct a greater part of the air flow more directly past the powder compartment. They al~o could be integrated with the abutments 10.
The tape 6 could also be arranged in such a manner that it can be removed entirely from the lower part 2. In this case the projections 7,8 are not needed, at least not for the purpos~ of guiding and holding the tape.
The deaggregation means can be designed in other ways than in the form of planar surfaces oriented at an - angle of about 20 - 50 relative to the direction of the air flow. This angle can of course also be varied outside this range and the surfaces do not necessarily have to be planar.
The material in the lower part and the tape does not necessarily have to comprise aluminium and may be any ; 20 pla~tic material having the necessary impermeability and stiffness or having been treated to have these properties.
. j It is also conceivable to make the inhaler from a single sheet which is rolled or folded after having been moulded in an appropriate way.
Claims (12)
1. Disposable breath-actuated inhaler comprising a tubular housing forming an air flow path being open at both ends, one end forming an air inlet (4) and one end forming an air outlet (5), said housing comprising a compartment (3) for storing a pharmaceutical powder to be inhaled, c h a r a c t e r i z e d in that the compartment (3) for storing the pharmaceutical powder is located close to the air inlet (4) and is covered by a thin foil (6) sealing the compartment in an airtight way which can be removed from the compartment from outside the housing, said housing being shaped with a constriction (9) adjacent the powder compartment (3) such that a turbulent air stream will be obtained at.
the constriction upon inhalation which will lift the powder out from the compartment (3) and mix the powder into the air stream.
the constriction upon inhalation which will lift the powder out from the compartment (3) and mix the powder into the air stream.
2. Inhaler according to claim 1, c h a r a c t e r i z -e d in that said powder compartment (3) is connected to the ambient air in its deepest part by means of one or several throughoholes (24).
3. Inhaler according to claim 1, c h a r a c t e r i z e d in that said housing is formed of two main parts, one moulded upper half (1) and one generally flat lower half (2) having an indentation (3) forming the powder compartment, said two halves (1, 2) being joined together along their longitudinal sides.
4. Inhaler according to anyone of claims 1 to 3, c h a r a c t e r i z e d in that the upper part (1) is moulded from a thin sheet, preferably of plastics material.
5. Inhaler according to claim 4, c h a r a c t e r i z e d in that said constriction (g) is formed as a depression in the upper side of said upper part (1) which is oriented transversely relative to the longitudinal extent of the tubular housing and located above the powder compartment (3) formed in the lower half (2) of the housing.
6. Inhaler according to any one of the preceding claims, c h a r a c t e r i z e d in that the lower half (2) is made of aluminium foil laminated with plastic.
7. Inhaler according to any one of the preceding claims, c h a r a c t e r i z e d in that the thin foil is in the shape of a tape (6) having one free end extending out through the air inlet (4), said tape being attached around the edges of the powder compartment (3) by means of relatively weak welds (22).
8. Inhaler according to claim 7, c h a r a c t e r i s e d in that the inner end of the tape (6) is attached to the lower half (4) between the air inlet (4) and the powder compartment (3), the tape (6) extending past, and being attached around, the powder compartment (3), the tape then being bent backwards about so as to extend out through the air inlet (4).
9. Inhaler according to claim 8, c h a r a c t e r i z e d in that the weak welds (22) form a point facing downstream in order to facilitate the initiation of the tearing action along the welds (22) when the tape (6) is to be pulled out through the air inlet (4) in order to expose the powder.
10. Inhaler according to any one of claims 7 - 9, c h a r a c t e r i z e d in that projections (7, 8) extend downwards from the upper half (1) between the powder compartment (3) and the air inlet (4) for holding the tape (6) against the lower half (2) of the housing in order to prevent the tape (6) from obstructing the air flow path.
11. Inhaler according to any one of the preceding claims, c h a r a c t e r i z e d in that deaggregation means (11, 12, 13, 14, 15, 16) are located in the air flow path between the powder compartment (3) and the air outlet (5).
12. Inhaler according to claim 11, c h a r a c t e r i z e d in that said deaggregation means comprise planar surfaces (11, 12, 13, 14, 15, 16) oriented 20° - 50°, preferably 25° - 35°, most preferably 30°, relative to the longitudinal direction of the tubular housing, said surf aces being disposed generally perpendicularly to a plane through the longitudinal axis of the tubular housing, a projection of the planar surfaces onto a cross-section of the housing substantially covering said cross-section.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92850046A EP0558879B1 (en) | 1992-03-04 | 1992-03-04 | Disposable inhaler |
EP92850046.1 | 1992-03-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2131157A1 true CA2131157A1 (en) | 1993-09-16 |
Family
ID=8212221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002131157A Abandoned CA2131157A1 (en) | 1992-03-04 | 1993-03-03 | Disposable inhaler ii |
Country Status (26)
Country | Link |
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US (1) | US5533505A (en) |
EP (2) | EP0558879B1 (en) |
JP (1) | JP3195351B2 (en) |
KR (1) | KR100248522B1 (en) |
CN (1) | CN1032293C (en) |
AT (1) | ATE167067T1 (en) |
AU (1) | AU666171B2 (en) |
BR (1) | BR9306023A (en) |
CA (1) | CA2131157A1 (en) |
CZ (1) | CZ281883B6 (en) |
DE (1) | DE69319100T2 (en) |
DK (1) | DK0629136T3 (en) |
EE (1) | EE03206B1 (en) |
ES (1) | ES2118223T3 (en) |
FI (1) | FI111444B (en) |
GR (1) | GR3027773T3 (en) |
HU (1) | HU215800B (en) |
MY (1) | MY116461A (en) |
NO (1) | NO307596B1 (en) |
NZ (1) | NZ249128A (en) |
RU (1) | RU2105573C1 (en) |
SG (1) | SG49134A1 (en) |
SK (1) | SK279223B6 (en) |
UA (1) | UA27056C2 (en) |
WO (1) | WO1993017728A1 (en) |
ZA (1) | ZA931520B (en) |
Families Citing this family (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU48707B (en) | 1990-03-02 | 1999-07-28 | Glaxo Group Limited | Inhalation device |
SK280968B6 (en) | 1990-03-02 | 2000-10-09 | Glaxo Group Limited | Medicament pack for use in an inhalation device |
US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
SE9203743D0 (en) * | 1992-12-11 | 1992-12-11 | Astra Ab | EFFICIENT USE |
US6250300B1 (en) | 1992-12-11 | 2001-06-26 | Ab Astra | System for dispensing pharmaceutically active compounds |
US5934272A (en) * | 1993-01-29 | 1999-08-10 | Aradigm Corporation | Device and method of creating aerosolized mist of respiratory drug |
US5819726A (en) * | 1993-01-29 | 1998-10-13 | Aradigm Corporation | Method for the delivery of aerosolized drugs to the lung for the treatment of respiratory disease |
US6098620A (en) * | 1993-01-29 | 2000-08-08 | Aradigm Corporation | Device for aerosolizing narcotics |
US6131567A (en) * | 1993-01-29 | 2000-10-17 | Aradigm Corporation | Method of use of monomeric insulin as a means for improving the reproducibility of inhaled insulin |
US5672581A (en) * | 1993-01-29 | 1997-09-30 | Aradigm Corporation | Method of administration of insulin |
US5873358A (en) * | 1993-01-29 | 1999-02-23 | Aradigm Corporation | Method of maintaining a diabetic patient's blood glucose level in a desired range |
US6024090A (en) | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
US5724957A (en) * | 1993-01-29 | 1998-03-10 | Aradigm Corporation | Intrapulmonary delivery of narcotics |
US5970973A (en) * | 1993-01-29 | 1999-10-26 | Aradigm Corporation | Method of delivering insulin lispro |
US5888477A (en) | 1993-01-29 | 1999-03-30 | Aradigm Corporation | Use of monomeric insulin as a means for improving the bioavailability of inhaled insulin |
US5915378A (en) * | 1993-01-29 | 1999-06-29 | Aradigm Corporation | Creating an aerosolized formulation of insulin |
US5558085A (en) * | 1993-01-29 | 1996-09-24 | Aradigm Corporation | Intrapulmonary delivery of peptide drugs |
US5743250A (en) | 1993-01-29 | 1998-04-28 | Aradigm Corporation | Insulin delivery enhanced by coached breathing |
US6012450A (en) * | 1993-01-29 | 2000-01-11 | Aradigm Corporation | Intrapulmonary delivery of hematopoietic drug |
TW360548B (en) | 1993-04-08 | 1999-06-11 | Powderject Res Ltd | Products for therapeutic use |
US5497763A (en) * | 1993-05-21 | 1996-03-12 | Aradigm Corporation | Disposable package for intrapulmonary delivery of aerosolized formulations |
DE4400084C2 (en) * | 1994-01-04 | 2001-08-02 | Softec Gmbh & Co Kg | Device for administering medication in solid form finely distributed in an air stream |
US5483954A (en) * | 1994-06-10 | 1996-01-16 | Mecikalski; Mark B. | Inhaler and medicated package |
US5522385A (en) * | 1994-09-27 | 1996-06-04 | Aradigm Corporation | Dynamic particle size control for aerosolized drug delivery |
TR199700669T1 (en) * | 1995-01-23 | 1998-02-21 | Direct-Haler A/S | �nhalat�r. |
US5676643A (en) * | 1995-02-13 | 1997-10-14 | The Procter & Gamble Company | Dispenser for friably releasing dry particulate medicaments |
SE9502800D0 (en) * | 1995-08-10 | 1995-08-10 | Astra Ab | Disposable inhalers |
SE9502799D0 (en) * | 1995-08-10 | 1995-08-10 | Astra Ab | Device in inhalers |
US7131441B1 (en) | 1995-12-07 | 2006-11-07 | Skyepharma Ag | Inhaler for multiple dosed administration of a pharmacological dry powder |
DK0865302T3 (en) | 1995-12-07 | 2000-10-02 | Jago Pharma Ag | Inhalator for repeated dose delivery of pharmacological dry powder |
CZ212598A3 (en) * | 1996-01-03 | 1998-11-11 | Glaxo Group Limited | Inhalation apparatus |
USD381416S (en) * | 1996-02-08 | 1997-07-22 | Astra Aktiebolag | Unit dose inhaler |
US5699789A (en) * | 1996-03-11 | 1997-12-23 | Hendricks; Mark R. | Dry powder inhaler |
US6123070A (en) * | 1996-06-07 | 2000-09-26 | Valois S.A. | Device for enhancing the emptying of an inhaler metering chamber |
SE9700423D0 (en) | 1997-02-07 | 1997-02-07 | Astra Ab | Disposable inhalers |
SE9700421D0 (en) | 1997-02-07 | 1997-02-07 | Astra Ab | Single dose inhalation I |
SE9700422D0 (en) * | 1997-02-07 | 1997-02-07 | Astra Ab | Single dose inhaler II |
US5881720A (en) * | 1997-04-29 | 1999-03-16 | The Procter & Gamble Company | Method of delivering halotherapy |
US6237590B1 (en) | 1997-09-18 | 2001-05-29 | Delsys Pharmaceutical Corporation | Dry powder delivery system apparatus |
EE200000546A (en) | 1998-03-16 | 2002-02-15 | Inhale Therapeutic Systems, Inc. | Aerosolized drug delivery system |
SE9800897D0 (en) | 1998-03-17 | 1998-03-17 | Astra Ab | Inhalation device |
UA73924C2 (en) * | 1998-10-09 | 2005-10-17 | Nektar Therapeutics | Device for delivering active agent formulation to lungs of human patient |
US6070575A (en) | 1998-11-16 | 2000-06-06 | Aradigm Corporation | Aerosol-forming porous membrane with certain pore structure |
GB9905538D0 (en) * | 1999-03-10 | 1999-05-05 | Glaxo Group Ltd | A device |
US6223744B1 (en) | 1999-03-16 | 2001-05-01 | Multi-Vet Ltd. | Wearable aerosol delivery apparatus |
GB9909357D0 (en) * | 1999-04-24 | 1999-06-16 | Glaxo Group Ltd | Medicament carrier |
GB9909354D0 (en) | 1999-04-24 | 1999-06-16 | Glaxo Group Ltd | Medicament carrier |
US9006175B2 (en) | 1999-06-29 | 2015-04-14 | Mannkind Corporation | Potentiation of glucose elimination |
US6606992B1 (en) | 1999-06-30 | 2003-08-19 | Nektar Therapeutics | Systems and methods for aerosolizing pharmaceutical formulations |
JP2003511107A (en) * | 1999-10-06 | 2003-03-25 | ゴルデマン・ラウル | Dry powder respiratory control inhaler and method of uniformly distributing and mixing dry powder in air |
US6427688B1 (en) | 2000-02-01 | 2002-08-06 | Dura Pharmaceuticals, Icn. | Dry powder inhaler |
AU3400501A (en) * | 2000-02-28 | 2001-09-12 | Vectura Ltd | Improvements in or relating to the delivery of oral drugs |
WO2001072605A1 (en) * | 2000-03-27 | 2001-10-04 | Dura Pharmaceuticals, Inc. | Containers for individual doses of an inhalable pharmaceutical |
AU2001283546A1 (en) | 2000-08-14 | 2002-02-25 | Advanced Inhalation Research, Inc. | Inhalation device and method |
US6443152B1 (en) | 2001-01-12 | 2002-09-03 | Becton Dickinson And Company | Medicament respiratory delivery device |
US6722364B2 (en) | 2001-01-12 | 2004-04-20 | Becton, Dickinson And Company | Medicament inhalation delivery devices and methods for using the same |
US6644309B2 (en) | 2001-01-12 | 2003-11-11 | Becton, Dickinson And Company | Medicament respiratory delivery device and method |
US6766799B2 (en) * | 2001-04-16 | 2004-07-27 | Advanced Inhalation Research, Inc. | Inhalation device |
US8061006B2 (en) | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
ATE332162T1 (en) * | 2001-11-22 | 2006-07-15 | Raul Goldemann | BREATH-CONTROLLED INHALATION DEVICE FOR DRY POWDER |
CA2479751C (en) | 2002-03-20 | 2008-06-03 | Trent Poole | Inhalation apparatus |
GR1004350B (en) | 2002-03-29 | 2003-09-26 | Inhaler for dry powder | |
AU2003267809A1 (en) * | 2002-06-07 | 2003-12-22 | Sun Pharmaceutical Industries Limited | Powder inhaler |
US7185651B2 (en) * | 2002-06-18 | 2007-03-06 | Nektar Therapeutics | Flow regulator for aerosol drug delivery and methods |
US6941947B2 (en) | 2002-12-18 | 2005-09-13 | Quadrant Technologies Limited | Unit dose dry powder inhaler |
EP1488819A1 (en) | 2003-06-16 | 2004-12-22 | Rijksuniversiteit te Groningen | Dry powder inhaler and method for pulmonary inhalation of dry powder |
GB2405798A (en) | 2003-09-15 | 2005-03-16 | Vectura Ltd | Dry powder inhaler with primary and secondary piercing elements and a medicament pack for use with an inhalation device. |
DK1675637T3 (en) * | 2003-10-21 | 2017-11-13 | Direct-Haler As | inhaler |
US8147426B2 (en) * | 2003-12-31 | 2012-04-03 | Nipro Diagnostics, Inc. | Integrated diagnostic test system |
FR2864944B1 (en) * | 2004-01-14 | 2006-03-31 | Valois Sas | STRIP OF BLISTERS FOR INHALER. |
NZ549590A (en) * | 2004-02-06 | 2010-05-28 | Microdose Therapeutx Inc | A blister pack for use with an inhalation device |
US20080090753A1 (en) | 2004-03-12 | 2008-04-17 | Biodel, Inc. | Rapid Acting Injectable Insulin Compositions |
CN1313184C (en) * | 2004-04-27 | 2007-05-02 | 贺文智 | Film pre-forming two flowing type nozzle, stillpot with the nozzle and technique for producing ultra-fine dust utilizing the stillpot |
ES2385934T3 (en) | 2004-08-20 | 2012-08-03 | Mannkind Corporation | CATALYSIS OF THE SYNTHESIS OF DICETOPIPERAZINA. |
KR101644250B1 (en) | 2004-08-23 | 2016-07-29 | 맨카인드 코포레이션 | Diketopiperazine salts, diketomorpholine salts or diketodioxane salts for drug delivery |
US8771257B2 (en) * | 2004-10-15 | 2014-07-08 | Boston Scientific Scimed, Inc. | Drug delivery sheath |
US20070012316A1 (en) * | 2005-07-14 | 2007-01-18 | Joann Truza | Disposable compact rescue inhaler |
DK1928423T3 (en) | 2005-09-14 | 2016-02-29 | Mannkind Corp | A method for drug formulation based on increasing the affinity of the active substances to the crystalline microparticle surfaces |
GB0520794D0 (en) | 2005-10-12 | 2005-11-23 | Innovata Biomed Ltd | Inhaler |
CN101631583B (en) * | 2005-12-22 | 2012-09-12 | 菲利普莫里斯生产公司 | Inhaler device |
US8039431B2 (en) | 2006-02-22 | 2011-10-18 | Mannkind Corporation | Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent |
PT103481B (en) * | 2006-05-16 | 2008-08-01 | Hovione Farmaciencia S A | INHALER OF SIMPLE USE AND INHALATION METHOD |
WO2008008021A1 (en) * | 2006-07-14 | 2008-01-17 | Astrazeneca Ab | Inhalation system and delivery device for the administration of a drug in the form of dry powder. |
JP5196878B2 (en) * | 2006-07-19 | 2013-05-15 | キヤノン株式会社 | Drug delivery device |
US20090283094A1 (en) * | 2006-07-19 | 2009-11-19 | Canon Kabushiki Kaisha | Medicine ejection device |
WO2008156586A2 (en) * | 2007-06-12 | 2008-12-24 | Alkermes, Inc. | Inhalation device for powdered substances |
EP2020249A1 (en) | 2007-08-01 | 2009-02-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Inhalator |
WO2009046072A1 (en) * | 2007-10-02 | 2009-04-09 | Baxter International Inc | Dry powder inhaler |
HUE027246T2 (en) * | 2008-01-24 | 2016-10-28 | Vectura Delivery Devices Ltd | Inhaler |
AU2009257311B2 (en) | 2008-06-13 | 2014-12-04 | Mannkind Corporation | A dry powder inhaler and system for drug delivery |
US8485180B2 (en) | 2008-06-13 | 2013-07-16 | Mannkind Corporation | Dry powder drug delivery system |
US9364619B2 (en) | 2008-06-20 | 2016-06-14 | Mannkind Corporation | Interactive apparatus and method for real-time profiling of inhalation efforts |
TWI532497B (en) | 2008-08-11 | 2016-05-11 | 曼凱公司 | Use of ultrarapid acting insulin |
US8314106B2 (en) | 2008-12-29 | 2012-11-20 | Mannkind Corporation | Substituted diketopiperazine analogs for use as drug delivery agents |
US9060927B2 (en) | 2009-03-03 | 2015-06-23 | Biodel Inc. | Insulin formulations for rapid uptake |
JP5667095B2 (en) | 2009-03-11 | 2015-02-12 | マンカインド コーポレイション | Apparatus, system and method for measuring inhaler resistance |
CA2764505C (en) | 2009-06-12 | 2018-09-25 | Mannkind Corporation | Diketopiperazine microparticles with defined specific surface areas |
BRPI1015579A2 (en) * | 2009-07-01 | 2019-09-24 | Astrazeneca Ab | dispenser and method for suspending dust in an air stream |
WO2011056889A1 (en) | 2009-11-03 | 2011-05-12 | Mannkind Corporation | An apparatus and method for simulating inhalation efforts |
RU2571331C1 (en) | 2010-06-21 | 2015-12-20 | Маннкайнд Корпорейшн | Systems and methods for dry powder drug delivery |
JP2012074674A (en) * | 2010-09-02 | 2012-04-12 | Canon Inc | Semiconductor integrated circuit device |
CN105667994B (en) | 2011-04-01 | 2018-04-06 | 曼金德公司 | Blister package for pharmaceutical kit |
WO2012174472A1 (en) | 2011-06-17 | 2012-12-20 | Mannkind Corporation | High capacity diketopiperazine microparticles |
WO2013036881A2 (en) * | 2011-09-07 | 2013-03-14 | Syphase, Llc | Dry powder inhalation device |
CA2852536A1 (en) | 2011-10-24 | 2013-05-02 | Mannkind Corporation | Methods and compositions for treating pain |
US9802012B2 (en) * | 2012-07-12 | 2017-10-31 | Mannkind Corporation | Dry powder drug delivery system and methods |
US10159644B2 (en) | 2012-10-26 | 2018-12-25 | Mannkind Corporation | Inhalable vaccine compositions and methods |
ES2754388T3 (en) | 2013-03-15 | 2020-04-17 | Mannkind Corp | Compositions and methods of microcrystalline dicetopiperazine |
US9925144B2 (en) | 2013-07-18 | 2018-03-27 | Mannkind Corporation | Heat-stable dry powder pharmaceutical compositions and methods |
EP3030294B1 (en) | 2013-08-05 | 2020-10-07 | MannKind Corporation | Insufflation apparatus |
US11491288B2 (en) | 2014-01-08 | 2022-11-08 | Seroton, Inc. | Dispenser for dry-powder inhalation devices |
US10238820B2 (en) | 2014-01-08 | 2019-03-26 | Seroton, Inc. | Dry-powder inhalation device |
US10307464B2 (en) | 2014-03-28 | 2019-06-04 | Mannkind Corporation | Use of ultrarapid acting insulin |
WO2015168572A2 (en) * | 2014-05-02 | 2015-11-05 | Manta Devices, Llc | Delivery device and related methods |
US10561806B2 (en) | 2014-10-02 | 2020-02-18 | Mannkind Corporation | Mouthpiece cover for an inhaler |
DE102014017409B4 (en) * | 2014-11-26 | 2016-06-09 | Klaus Dieter Beller | Single-dose powder inhaler and process for its preparation |
CA2991221A1 (en) | 2015-07-02 | 2017-01-05 | Marc Andrew Koska | Single use delivery device prefilled with a reconstitutable agent |
WO2017187262A1 (en) | 2016-04-25 | 2017-11-02 | Marc Andrew Koska | Medical delivery system |
AU2018244582A1 (en) | 2017-03-28 | 2019-09-19 | Concentrx Pharmaceuticals, Inc. | Devices and methods for delivering dry powder medicaments |
CN110709124A (en) * | 2017-04-06 | 2020-01-17 | 迈兰公司 | Low cost single use powder inhaler |
EP3710086A4 (en) | 2017-11-17 | 2021-11-17 | Koska Family Limited | Systems and methods for fluid delivery manifolds |
USD992110S1 (en) | 2021-08-10 | 2023-07-11 | Koska Family Limited | Sealed fluid container |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US481780A (en) * | 1892-08-30 | Uviversal coupling | ||
US2549303A (en) * | 1949-04-20 | 1951-04-17 | Bristol Lab Inc | Inhaler for crystalline pencilllin or the like |
US4265236A (en) * | 1980-03-31 | 1981-05-05 | Pacella Angelo M | Portable inhalator device |
FR2585563B1 (en) * | 1985-07-30 | 1993-11-12 | Glaxo Group Ltd | DEVICE FOR ADMINISTERING MEDICINES TO PATIENTS |
AT384552B (en) * | 1985-08-01 | 1987-12-10 | Hurka Wilhelm | INHALATION DEVICE FOR DOSING AND DISTRIBUTING SOLID BODIES INTO THE BREATHING AIR |
CA1329526C (en) * | 1987-08-20 | 1994-05-17 | Hiroshi Ikura | Powdery medicine applicator device |
GB8914223D0 (en) * | 1989-06-21 | 1989-08-09 | Fisons Plc | Medicament container |
US5239991A (en) * | 1989-06-21 | 1993-08-31 | Fisons Plc | Disposable powder medicament inhalation device with peel-off cover |
SE9002895D0 (en) * | 1990-09-12 | 1990-09-12 | Astra Ab | INHALATION DEVICES FOR DISPENSING POWDERS I |
US5042472A (en) * | 1990-10-15 | 1991-08-27 | Merck & Co., Inc. | Powder inhaler device |
-
1992
- 1992-03-04 EP EP92850046A patent/EP0558879B1/en not_active Expired - Lifetime
-
1993
- 1993-03-03 DE DE69319100T patent/DE69319100T2/en not_active Expired - Fee Related
- 1993-03-03 ES ES93904034T patent/ES2118223T3/en not_active Expired - Lifetime
- 1993-03-03 UA UA94095772A patent/UA27056C2/en unknown
- 1993-03-03 BR BR9306023A patent/BR9306023A/en not_active IP Right Cessation
- 1993-03-03 US US08/295,709 patent/US5533505A/en not_active Expired - Lifetime
- 1993-03-03 SK SK1049-94A patent/SK279223B6/en unknown
- 1993-03-03 AT AT93904034T patent/ATE167067T1/en not_active IP Right Cessation
- 1993-03-03 DK DK93904034T patent/DK0629136T3/en active
- 1993-03-03 WO PCT/EP1993/000473 patent/WO1993017728A1/en active IP Right Grant
- 1993-03-03 EP EP93904034A patent/EP0629136B1/en not_active Expired - Lifetime
- 1993-03-03 KR KR1019940703083A patent/KR100248522B1/en not_active IP Right Cessation
- 1993-03-03 CZ CZ942084A patent/CZ281883B6/en unknown
- 1993-03-03 HU HU9402541A patent/HU215800B/en not_active IP Right Cessation
- 1993-03-03 JP JP51531093A patent/JP3195351B2/en not_active Expired - Fee Related
- 1993-03-03 AU AU34997/93A patent/AU666171B2/en not_active Ceased
- 1993-03-03 RU RU94040868A patent/RU2105573C1/en not_active IP Right Cessation
- 1993-03-03 SG SG1996006511A patent/SG49134A1/en unknown
- 1993-03-03 NZ NZ249128A patent/NZ249128A/en unknown
- 1993-03-03 CA CA002131157A patent/CA2131157A1/en not_active Abandoned
- 1993-03-03 ZA ZA931520A patent/ZA931520B/en unknown
- 1993-03-04 CN CN93103571A patent/CN1032293C/en not_active Expired - Fee Related
- 1993-03-04 MY MYPI93000386A patent/MY116461A/en unknown
-
1994
- 1994-08-30 NO NO943211A patent/NO307596B1/en not_active IP Right Cessation
- 1994-09-02 FI FI944034A patent/FI111444B/en not_active IP Right Cessation
- 1994-11-08 EE EE9400293A patent/EE03206B1/en not_active IP Right Cessation
-
1998
- 1998-08-28 GR GR980401952T patent/GR3027773T3/en unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |