CA2132865A1 - Transdermal administration of oxybutynin - Google Patents
Transdermal administration of oxybutyninInfo
- Publication number
- CA2132865A1 CA2132865A1 CA002132865A CA2132865A CA2132865A1 CA 2132865 A1 CA2132865 A1 CA 2132865A1 CA 002132865 A CA002132865 A CA 002132865A CA 2132865 A CA2132865 A CA 2132865A CA 2132865 A1 CA2132865 A1 CA 2132865A1
- Authority
- CA
- Canada
- Prior art keywords
- oxybutynin
- transdermal administration
- permeation
- skin
- permeation enhancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention is directed to the transdermal administration of oxybutynin together with a suitable permeation en-hancer. The invention includes a transdermal drug delivery device comprising a matrix adapted to be placed in oxybutynin- and permeation enhancer-transmitting relation with the skin site. The matrix contains sufficient amounts of a permeation enhancer and of oxybutynin, in combination, to continuously administer to the skin for a predetermined period of time the oxybutynin to provide an effective therapeutic result. The invention is also directed to a method for the transdermal administration of a thera-peutically effective amount of oxybutynin together with a skin permeation-enhancing amount of a suitable permeation enhancer.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88265292A | 1992-05-13 | 1992-05-13 | |
US07/882,652 | 1992-05-13 | ||
PCT/US1993/004518 WO1993023025A1 (en) | 1992-05-13 | 1993-05-13 | Transdermal administration of oxybutynin |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2132865A1 true CA2132865A1 (en) | 1993-11-25 |
CA2132865C CA2132865C (en) | 2003-12-02 |
Family
ID=25381055
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002132865A Expired - Fee Related CA2132865C (en) | 1992-05-13 | 1993-05-13 | Transdermal administration of oxybutynin |
Country Status (15)
Country | Link |
---|---|
US (2) | US5411740A (en) |
EP (1) | EP0767659B1 (en) |
JP (1) | JP3786684B2 (en) |
KR (1) | KR950701516A (en) |
AT (1) | ATE185694T1 (en) |
AU (1) | AU666735B2 (en) |
CA (1) | CA2132865C (en) |
DE (1) | DE69326848T2 (en) |
ES (1) | ES2137261T3 (en) |
FI (1) | FI945311A0 (en) |
MX (1) | MX9302812A (en) |
NO (1) | NO944249L (en) |
NZ (1) | NZ252598A (en) |
WO (1) | WO1993023025A1 (en) |
ZA (1) | ZA933349B (en) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5900250A (en) | 1992-05-13 | 1999-05-04 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer for oxybutnin |
ATE149349T1 (en) * | 1993-06-25 | 1997-03-15 | Alza Corp | INCORPORATING A POLY-N-VINYLAMIDE INTO A TRANSDERMAL SYSTEM |
CA2165802A1 (en) * | 1993-09-29 | 1995-04-06 | Eun Soo Lee | Monoglyceride/lactate ester permeation enhancer for oxybutynin |
US5399359A (en) * | 1994-03-04 | 1995-03-21 | Edward Mendell Co., Inc. | Controlled release oxybutynin formulations |
WO1995031190A1 (en) * | 1994-05-18 | 1995-11-23 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable preparation for treating urination disorder |
US5635203A (en) * | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
EP1057479A1 (en) * | 1994-12-14 | 2000-12-06 | Enbalt Trading Limited | Pharmaceutical tablet formulations for direct compression |
US5532278A (en) * | 1995-01-31 | 1996-07-02 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin |
SE9501670L (en) * | 1995-05-05 | 1996-06-10 | Perstorp Ab | Omläggningsset |
US5730721A (en) | 1996-01-25 | 1998-03-24 | Vesture Corporation | Medical applicator and method |
US6171298B1 (en) | 1996-05-03 | 2001-01-09 | Situs Corporation | Intravesical infuser |
AU4990797A (en) * | 1996-10-24 | 1998-05-15 | Alza Corporation | Permeation enhancers for transdermal drug delivery compositions, devices, and methods |
US5968547A (en) | 1997-02-24 | 1999-10-19 | Euro-Celtique, S.A. | Method of providing sustained analgesia with buprenorphine |
US6660295B2 (en) | 1997-09-30 | 2003-12-09 | Alza Corporation | Transdermal drug delivery device package with improved drug stability |
AU1728099A (en) | 1997-12-22 | 1999-07-12 | Alza Corporation | Monoglyceride and ethyl palmitate permeation enhancer compositions |
US6183461B1 (en) | 1998-03-11 | 2001-02-06 | Situs Corporation | Method for delivering a medication |
EP0957073A1 (en) | 1998-05-12 | 1999-11-17 | Schwarz Pharma Ag | Novel derivatives of 3,3-diphenylpropylamines |
HUP0103206A3 (en) * | 1998-06-25 | 2002-11-28 | Lavipharm Lab Inc Piscataway | A device and method for the treatment of erectile dysfunction and for its making |
SE9802864D0 (en) | 1998-08-27 | 1998-08-27 | Pharmacia & Upjohn Ab | Transdermally administered tolterodine as an antimuscarinic agent for the treatment of overactive bladder |
CZ302630B6 (en) * | 1998-08-27 | 2011-08-10 | Pharmacia & Upjohn Ab | Pharmaceutical composition containing tolterodine or tolterodine-related compound |
US6348210B1 (en) | 1998-11-13 | 2002-02-19 | Alza Corporation | Methods for transdermal drug administration |
ES2336054T3 (en) * | 1998-12-18 | 2010-04-07 | Alza Corporation | TRANSPARENT DEVICE FOR THE TRANSDERMIC ADMINISTRATION OF NICOTINE. |
KR100622332B1 (en) * | 1999-04-01 | 2006-09-13 | 알자 코포레이션 | Transdermal drug delivery devices comprising a polyurethane drug reservoir |
JP4643018B2 (en) * | 1999-04-13 | 2011-03-02 | 久光製薬株式会社 | Transdermal preparation |
SK6412002A3 (en) | 1999-11-11 | 2002-09-10 | Pharmacia Ab | Pharmaceutical formulation containing tolterodine and its use |
US6586000B2 (en) | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
US20030104041A1 (en) * | 1999-12-16 | 2003-06-05 | Tsung-Min Hsu | Transdermal and topical administration of drugs using basic permeation enhancers |
US6673363B2 (en) | 1999-12-16 | 2004-01-06 | Dermatrends, Inc. | Transdermal and topical administration of local anesthetic agents using basic enhancers |
US6562368B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
US6582724B2 (en) | 1999-12-16 | 2003-06-24 | Dermatrends, Inc. | Dual enhancer composition for topical and transdermal drug delivery |
US6436428B1 (en) | 2000-03-21 | 2002-08-20 | Enhance Pharmaceuticals, Inc. | Device and method for treating urinary incontinence in females |
US7029694B2 (en) * | 2000-04-26 | 2006-04-18 | Watson Laboratories, Inc. | Compositions and methods for transdermal oxybutynin therapy |
CN101305994A (en) * | 2000-04-26 | 2008-11-19 | 沃特森药物公司 | Minimizing adverse experience associated with oxybutynin therapy |
US7179483B2 (en) * | 2000-04-26 | 2007-02-20 | Watson Pharmaceuticals, Inc. | Compositions and methods for transdermal oxybutynin therapy |
US20030124177A1 (en) * | 2000-04-26 | 2003-07-03 | Watson Pharmaceuticals, Inc. | Compositions and methods for transdermal oxybutynin therapy |
US6545046B2 (en) | 2000-08-30 | 2003-04-08 | Theramax Inc. | Method for enhanced delivery of oxybutynin and compositions thereof |
DE10060550C1 (en) * | 2000-12-06 | 2002-04-18 | Lohmann Therapie Syst Lts | Transdermal therapeutic system for administration of oxybutynin, especially for treatment of bladder dysfunction, having two-phase matrix layer of active agent-containing droplets dispersed in adhesive |
ITMI20012060A1 (en) * | 2001-10-05 | 2003-04-05 | Recordati Chem Pharm | NEW N-ACYLATED HETEROCYCLES |
US6773421B2 (en) | 2001-12-14 | 2004-08-10 | Kimberly-Clark Worlwide, Inc. | Combination for managing the involuntary loss of bladder control |
US7921999B1 (en) * | 2001-12-20 | 2011-04-12 | Watson Laboratories, Inc. | Peelable pouch for transdermal patch and method for packaging |
DE10224556A1 (en) * | 2002-05-31 | 2004-01-08 | Grünenthal GmbH | Medicament containing 1-dimethylamino-3- (3-methoxy-phenyl) 2-methyl-pentan-3-ol in various formulations |
US8246980B2 (en) * | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system |
US8246979B2 (en) | 2002-07-30 | 2012-08-21 | Ucb Pharma Gmbh | Transdermal delivery system for the administration of rotigotine |
NZ537991A (en) | 2002-08-30 | 2007-08-31 | Alza Corp | Embossable and writable multilaminate backing construction |
DE10251256A1 (en) * | 2002-11-04 | 2004-05-13 | Novosis Ag | Transdermal drug delivery system for oxybutynin |
CA2518329C (en) | 2003-03-12 | 2015-11-24 | Epitome Pharmaceuticals Limited | Rapidly absorbing lipophilic skin compositions and uses therefor |
WO2004087099A2 (en) * | 2003-03-26 | 2004-10-14 | Lavipharm S.A. | Methods and devices for holding a composition |
DE10315917A1 (en) * | 2003-04-08 | 2004-11-18 | Schwarz Pharma Ag | Highly pure bases of 3,3-diphenylpropylamine monoesters |
DE10315878B4 (en) * | 2003-04-08 | 2009-06-04 | Schwarz Pharma Ag | Device for transdermal administration of fesoterodine and use |
US7105263B2 (en) * | 2003-12-30 | 2006-09-12 | Samsung Electronics Company | Dry toner comprising encapsulated pigment, methods and uses |
US20060008432A1 (en) * | 2004-07-07 | 2006-01-12 | Sebastiano Scarampi | Gilsonite derived pharmaceutical delivery compositions and methods: nail applications |
US8252319B2 (en) | 2004-10-21 | 2012-08-28 | Durect Corporation | Transdermal delivery system for sufentanil |
SI1814531T1 (en) | 2004-10-21 | 2010-10-29 | Durect Corp | Transdermal delivery systems |
DK1895994T3 (en) * | 2005-05-13 | 2010-12-20 | Alza Corp | Multilayer drug delivery system with barrier against reservoir material flow |
EP1743638A1 (en) | 2005-07-15 | 2007-01-17 | Laboratorios Del Dr. Esteve, S.A. | Pharmaceutical formulations of substituted pyrazoline compounds |
US10010494B2 (en) | 2005-10-19 | 2018-07-03 | Menni Menashe Zinger | Methods for the treatment of hyperhidrosis |
US8518926B2 (en) * | 2006-04-10 | 2013-08-27 | Knopp Neurosciences, Inc. | Compositions and methods of using (R)-pramipexole |
US20070259930A1 (en) * | 2006-04-10 | 2007-11-08 | Knopp Neurosciences, Inc. | Compositions and methods of using r(+) pramipexole |
CA2652251A1 (en) | 2006-05-16 | 2007-11-29 | Knopp Neurosciences, Inc. | Compositions of r(+) and s(-) pramipexole and methods for using the same |
US8524695B2 (en) * | 2006-12-14 | 2013-09-03 | Knopp Neurosciences, Inc. | Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same |
US20100041704A1 (en) * | 2007-01-12 | 2010-02-18 | Aberg A K Gunnar | Dermal compositions of substituted amides and the use thereof as medication for pain and pruritus |
US8519148B2 (en) * | 2007-03-14 | 2013-08-27 | Knopp Neurosciences, Inc. | Synthesis of chirally purified substituted benzothiazole diamines |
EP2230911A4 (en) * | 2007-12-21 | 2013-07-03 | Zars Pharma Inc | Patches, formulations, and associated methods for transdermal delivery of alprazolam and other drugs |
KR20110071064A (en) | 2008-08-19 | 2011-06-28 | 크놉 뉴로사이언시스 인코포레이티드 | Compositions and methods of using (r)-pramipexole |
CA2765876A1 (en) * | 2009-06-19 | 2010-12-23 | Knopp Neurosciences, Inc. | Compositions and methods for treating amyotrophic lateral sclerosis |
JP6527305B2 (en) | 2011-01-10 | 2019-06-05 | インヴィオン, インコーポレイテッド | Use of beta-adrenergic inverse agonists for smoking cessation |
WO2013061969A1 (en) * | 2011-10-26 | 2013-05-02 | 久光製薬株式会社 | Oxybutynin-containing transdermal absorption preparation |
US9512096B2 (en) | 2011-12-22 | 2016-12-06 | Knopp Biosciences, LLP | Synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds |
US9662313B2 (en) | 2013-02-28 | 2017-05-30 | Knopp Biosciences Llc | Compositions and methods for treating amyotrophic lateral sclerosis in responders |
US9682068B2 (en) | 2013-05-20 | 2017-06-20 | Mylan Inc. | Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders |
US9468630B2 (en) | 2013-07-12 | 2016-10-18 | Knopp Biosciences Llc | Compositions and methods for treating conditions related to increased eosinophils |
RS61539B1 (en) | 2013-07-12 | 2021-04-29 | Knopp Biosciences Llc | Treating elevated levels of eosinophils and/or basophils |
CA2921381A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating chronic urticaria |
WO2015023786A1 (en) | 2013-08-13 | 2015-02-19 | Knopp Biosciences Llc | Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders |
US10149828B2 (en) | 2015-01-09 | 2018-12-11 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system combination |
Family Cites Families (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL281225A (en) * | 1961-07-20 | |||
GB1031303A (en) * | 1964-01-16 | 1966-06-02 | Boving & Co Ltd | Improvements in and relating to hydraulic valves |
US3598123A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US3797494A (en) * | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
US3598122A (en) * | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
US4405616A (en) * | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
US4031894A (en) * | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
US4130667A (en) * | 1976-01-12 | 1978-12-19 | The Procter & Gamble Company | Dermatological compositions |
US4335115A (en) * | 1976-11-01 | 1982-06-15 | The Procter & Gamble Company | Anti-acne composition |
US4201211A (en) * | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
US4299826A (en) * | 1979-10-12 | 1981-11-10 | The Procter & Gamble Company | Anti-acne composition |
US4286592A (en) * | 1980-02-04 | 1981-09-01 | Alza Corporation | Therapeutic system for administering drugs to the skin |
US4314557A (en) * | 1980-05-19 | 1982-02-09 | Alza Corporation | Dissolution controlled active agent dispenser |
US4379454A (en) * | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
US4343798A (en) * | 1981-06-23 | 1982-08-10 | The Procter & Gamble Company | Topical antimicrobial anti-inflammatory compositions |
US4849226A (en) * | 1981-06-29 | 1989-07-18 | Alza Corporation | Method for increasing oxygen supply by administering vasodilator |
US4435180A (en) * | 1982-05-25 | 1984-03-06 | Alza Corporation | Elastomeric active agent delivery system and method of use |
US4474845A (en) * | 1982-08-26 | 1984-10-02 | General Motors Corporation | Compacted sheet molding compound |
US4559222A (en) * | 1983-05-04 | 1985-12-17 | Alza Corporation | Matrix composition for transdermal therapeutic system |
US4747845A (en) * | 1983-10-17 | 1988-05-31 | Enquay Pharmaceutical Associates | Synthetic resin matrix system for the extended delivery of drugs |
US4704282A (en) * | 1984-06-29 | 1987-11-03 | Alza Corporation | Transdermal therapeutic system having improved delivery characteristics |
US4588580B2 (en) * | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
US4573995A (en) * | 1984-10-09 | 1986-03-04 | Alza Corporation | Transdermal therapeutic systems for the administration of naloxone, naltrexone and nalbuphine |
US4568343A (en) * | 1984-10-09 | 1986-02-04 | Alza Corporation | Skin permeation enhancer compositions |
US4645502A (en) * | 1985-05-03 | 1987-02-24 | Alza Corporation | Transdermal delivery of highly ionized fat insoluble drugs |
BE902605A (en) * | 1985-06-06 | 1985-09-30 | Therabel Res S A N V | Medicaments for treating urinary tract disorders - contg. oxybutynin chloride |
US4784857A (en) * | 1986-06-03 | 1988-11-15 | Smith And Nephew Associated Companies Plc | Drug delivery device, its preparation and use |
US4908027A (en) * | 1986-09-12 | 1990-03-13 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
US4788062A (en) * | 1987-02-26 | 1988-11-29 | Alza Corporation | Transdermal administration of progesterone, estradiol esters, and mixtures thereof |
US4746515A (en) * | 1987-02-26 | 1988-05-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolaurate |
US4940586A (en) * | 1987-02-26 | 1990-07-10 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
US4865848A (en) * | 1987-02-26 | 1989-09-12 | Alza Corporation | Skin permeation enhancer compositions using sucrose esters |
US4816258A (en) * | 1987-02-26 | 1989-03-28 | Alza Corporation | Transdermal contraceptive formulations |
US5071656A (en) * | 1987-03-05 | 1991-12-10 | Alza Corporation | Delayed onset transdermal delivery device |
US4820720A (en) * | 1987-08-24 | 1989-04-11 | Alza Corporation | Transdermal drug composition with dual permeation enhancers |
GB8721659D0 (en) * | 1987-09-15 | 1987-10-21 | Smith & Nephew Ass | Adhesive coated dressings & applicators |
US4943435A (en) * | 1987-10-05 | 1990-07-24 | Pharmetrix Corporation | Prolonged activity nicotine patch |
US4849224A (en) * | 1987-11-12 | 1989-07-18 | Theratech Inc. | Device for administering an active agent to the skin or mucosa |
US4863738A (en) * | 1987-11-23 | 1989-09-05 | Alza Corporation | Skin permeation enhancer compositions using glycerol monooleate |
US4994278A (en) * | 1988-03-04 | 1991-02-19 | Noven Pharmaceuticals, Inc. | Breathable backing |
US5004610A (en) * | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
JP3243564B2 (en) * | 1990-08-20 | 2002-01-07 | リードケミカル株式会社 | External patch |
US5152997A (en) * | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
JP3136413B2 (en) * | 1991-02-22 | 2001-02-19 | リードケミカル株式会社 | Percutaneous absorption type pollakiuria / urinary incontinence treatment |
JPH04273818A (en) * | 1991-02-28 | 1992-09-30 | Kissei Pharmaceut Co Ltd | Percutaneous administration preparation |
PT100502A (en) * | 1991-05-20 | 1993-08-31 | Alza Corp | PHARMACEUTICAL COMPOSITIONS FOR INCREASING THE CAPACITY OF PERMEACAO IN THE SKIN USING GLYCEROL MONOLINOLEATE |
-
1993
- 1993-05-13 MX MX9302812A patent/MX9302812A/en unknown
- 1993-05-13 AT AT93911284T patent/ATE185694T1/en not_active IP Right Cessation
- 1993-05-13 CA CA002132865A patent/CA2132865C/en not_active Expired - Fee Related
- 1993-05-13 EP EP93911284A patent/EP0767659B1/en not_active Expired - Lifetime
- 1993-05-13 DE DE69326848T patent/DE69326848T2/en not_active Expired - Fee Related
- 1993-05-13 WO PCT/US1993/004518 patent/WO1993023025A1/en active IP Right Grant
- 1993-05-13 NZ NZ252598A patent/NZ252598A/en not_active IP Right Cessation
- 1993-05-13 JP JP50372594A patent/JP3786684B2/en not_active Expired - Fee Related
- 1993-05-13 KR KR1019940704052A patent/KR950701516A/en not_active IP Right Cessation
- 1993-05-13 ES ES93911284T patent/ES2137261T3/en not_active Expired - Lifetime
- 1993-05-13 ZA ZA933349A patent/ZA933349B/en unknown
- 1993-05-13 AU AU42473/93A patent/AU666735B2/en not_active Ceased
-
1994
- 1994-02-08 US US08/193,661 patent/US5411740A/en not_active Expired - Lifetime
- 1994-11-08 NO NO944249A patent/NO944249L/en unknown
- 1994-11-11 FI FI945311A patent/FI945311A0/en not_active Application Discontinuation
-
1995
- 1995-02-15 US US08/388,767 patent/US5500222A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ZA933349B (en) | 1994-06-15 |
DE69326848T2 (en) | 2000-01-27 |
NO944249D0 (en) | 1994-11-08 |
ES2137261T3 (en) | 1999-12-16 |
JPH08502952A (en) | 1996-04-02 |
AU666735B2 (en) | 1996-02-22 |
US5411740A (en) | 1995-05-02 |
WO1993023025A1 (en) | 1993-11-25 |
FI945311A (en) | 1994-11-11 |
NZ252598A (en) | 1997-01-29 |
AU4247393A (en) | 1993-12-13 |
CA2132865C (en) | 2003-12-02 |
ATE185694T1 (en) | 1999-11-15 |
FI945311A0 (en) | 1994-11-11 |
KR950701516A (en) | 1995-04-28 |
EP0767659A1 (en) | 1997-04-16 |
NO944249L (en) | 1994-11-14 |
DE69326848D1 (en) | 1999-11-25 |
US5500222A (en) | 1996-03-19 |
MX9302812A (en) | 1993-11-01 |
EP0767659B1 (en) | 1999-10-20 |
JP3786684B2 (en) | 2006-06-14 |
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Legal Events
Date | Code | Title | Description |
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EEER | Examination request | ||
MKLA | Lapsed |